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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: TAF1 (ImmuneEditome ID:6872)

1. Gene summary of enriched editing regions for TAF1

check button Gene summary
Gene informationGene symbol

TAF1

Gene ID

6872

GeneSynonymsBA2R|CCG1|CCGS|DYT3|DYT3/TAF1|KAT4|MRXS33|N-TAF1|NSCL2|OF|P250|TAF(II)250|TAF2A|TAFII-250|TAFII250|XDP
GeneCytomap

Xq13.1

GeneTypeprotein-coding
GeneDescriptiontranscription initiation factor TFIID subunit 1|TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa|TBP-associated factor 250 kDa|cell cycle gene 1 protein|cell cycle, G1 phase defect|complementation of cell cycle block, G1-to-S|transcription factor TFIID p250 polypeptide
GeneModificationdate20230517
UniprotIDA0A804HK58;A0A804HIY8;A0A804HIC2;A0A804HK00
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chrX:71408368-71409440:+ENST00000276072.6ENSG00000147133.14TAF1intronicAluSg,AluJo,AluYcchrX:71408368-71409440:+.alignment
chrX:71408368-71409440:+ENST00000373775.7ENSG00000147133.14TAF1intronicAluSg,AluJo,AluYcchrX:71408368-71409440:+.alignment
chrX:71408368-71409440:+ENST00000373790.7ENSG00000147133.14TAF1intronicAluSg,AluJo,AluYcchrX:71408368-71409440:+.alignment
chrX:71408368-71409440:+ENST00000423759.4ENSG00000147133.14TAF1intronicAluSg,AluJo,AluYcchrX:71408368-71409440:+.alignment
chrX:71408368-71409440:+ENST00000437147.6ENSG00000147133.14TAF1intronicAluSg,AluJo,AluYcchrX:71408368-71409440:+.alignment
chrX:71408368-71409440:+ENST00000463163.4ENSG00000147133.14TAF1intronicAluSg,AluJo,AluYcchrX:71408368-71409440:+.alignment
chrX:71411091-71412235:+ENST00000276072.6ENSG00000147133.14TAF1intronicAluSz,AluJr,AluSz6,MIR,L1MB7,AluSpchrX:71411091-71412235:+.alignment
chrX:71411091-71412235:+ENST00000373775.7ENSG00000147133.14TAF1intronicAluSz,AluJr,AluSz6,MIR,L1MB7,AluSpchrX:71411091-71412235:+.alignment
chrX:71411091-71412235:+ENST00000373790.7ENSG00000147133.14TAF1intronicAluSz,AluJr,AluSz6,MIR,L1MB7,AluSpchrX:71411091-71412235:+.alignment
chrX:71411091-71412235:+ENST00000423759.4ENSG00000147133.14TAF1intronicAluSz,AluJr,AluSz6,MIR,L1MB7,AluSpchrX:71411091-71412235:+.alignment
chrX:71411091-71412235:+ENST00000437147.6ENSG00000147133.14TAF1intronicAluSz,AluJr,AluSz6,MIR,L1MB7,AluSpchrX:71411091-71412235:+.alignment
chrX:71411091-71412235:+ENST00000463163.4ENSG00000147133.14TAF1intronicAluSz,AluJr,AluSz6,MIR,L1MB7,AluSpchrX:71411091-71412235:+.alignment
chrX:71416257-71417668:+ENST00000463163.4ENSG00000147133.14TAF1exonicFLAM_C,MSTC,AluJochrX:71416257-71417668:+.alignment


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2. Tumor-specific enriched editing regions for TAF1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000147133.14,TAF1THCAPathEAG7.7901e-075.1667e-050.2378image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for TAF1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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4. Enriched editing regions and immune related splicing for TAF1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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5. Enriched editing regions and immune infiltration for TAF1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000147133.14,TAF1BLCAEAGMacrophages_M04.0625e-02-0.1428image
ENSG00000147133.14,TAF1BRCAEAGDendritic_cells_activated1.0319e-030.1265image
ENSG00000147133.14,TAF1COADEAGEosinophils9.8673e-100.6215image
chrX:71411091-71412235:+ESCAEERNK_cells_resting2.1138e-02-0.3191image
ENSG00000147133.14,TAF1ESCAEAGT_cells_regulatory_(Tregs)2.3297e-020.2223image
ENSG00000147133.14,TAF1GBMEAGT_cells_follicular_helper3.9599e-02-0.3842image
ENSG00000147133.14,TAF1HNSCEAGDendritic_cells_activated7.0082e-030.2354image
ENSG00000147133.14,TAF1KIRCEAGT_cells_gamma_delta2.8337e-020.1713image
ENSG00000147133.14,TAF1KIRPEAGB_cells_memory2.0755e-040.5734image
chrX:71411091-71412235:+LAMLEERT_cells_follicular_helper2.0078e-020.2533image
ENSG00000147133.14,TAF1LGGEAGT_cells_regulatory_(Tregs)1.8955e-02-0.1859image
ENSG00000147133.14,TAF1LUADEAGNK_cells_resting8.4176e-03-0.1504image
ENSG00000147133.14,TAF1LUSCEAGT_cells_regulatory_(Tregs)4.8343e-020.1318image
ENSG00000147133.14,TAF1OVEAGT_cells_follicular_helper1.3699e-030.2355image
ENSG00000147133.14,TAF1PAADEAGNK_cells_resting3.3341e-030.3096image
ENSG00000147133.14,TAF1PCPGEAGT_cells_CD84.1024e-020.2037image
ENSG00000147133.14,TAF1PRADEAGT_cells_CD4_memory_resting1.9684e-030.2209image
ENSG00000147133.14,TAF1SARCEAGEosinophils2.7171e-020.1960image
ENSG00000147133.14,TAF1SKCMEAGPlasma_cells1.4769e-020.2118image
chrX:71408368-71409440:+STADEERPlasma_cells2.0291e-020.4706image
chrX:71416257-71417668:+STADEERNK_cells_activated3.7600e-030.3519image
ENSG00000147133.14,TAF1STADEAGNK_cells_activated1.3599e-020.1622image
ENSG00000147133.14,TAF1TGCTEAGPlasma_cells1.7937e-020.3098image
ENSG00000147133.14,TAF1THCAEAGT_cells_regulatory_(Tregs)5.3025e-030.1650image
ENSG00000147133.14,TAF1THYMEAGMacrophages_M01.4003e-030.5406image
ENSG00000147133.14,TAF1UCECEAGMast_cells_resting8.3017e-030.2737image


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6. Enriched editing regions and immune gene sets for TAF1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000147133.14,TAF1COADEAG1.8047e-04-0.40923.1936e-02-0.24163.9418e-05-0.44521.2247e-02-0.2806image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000147133.14,TAF1BLCAGSVA_HALLMARK_APICAL_SURFACEEAG1.4706e-020.1698image
ENSG00000147133.14,TAF1BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.9343e-080.2103image
ENSG00000147133.14,TAF1COADGSVA_HALLMARK_UV_RESPONSE_UPEAG5.4511e-07-0.5288image
ENSG00000147133.14,TAF1ESCAGSVA_HALLMARK_SPERMATOGENESISEAG4.6219e-03-0.2757image
ENSG00000147133.14,TAF1GBMGSVA_HALLMARK_COAGULATIONEAG1.4833e-030.5628image
ENSG00000147133.14,TAF1HNSCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG4.5210e-03-0.2475image
ENSG00000147133.14,TAF1KIRCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG2.4478e-02-0.1756image
ENSG00000147133.14,TAF1KIRPGSVA_HALLMARK_P53_PATHWAYEAG4.2276e-03-0.4594image
chrX:71411091-71412235:+LAMLGSVA_HALLMARK_KRAS_SIGNALING_DNEER2.7020e-020.2413image
ENSG00000147133.14,TAF1LGGGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG2.0454e-02-0.1837image
ENSG00000147133.14,TAF1LIHCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.9781e-020.1940image
ENSG00000147133.14,TAF1LUADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG6.5185e-040.1938image
ENSG00000147133.14,TAF1LUSCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG3.9766e-020.1372image
ENSG00000147133.14,TAF1MESOGSVA_HALLMARK_APICAL_SURFACEEAG1.9647e-020.3820image
ENSG00000147133.14,TAF1OVGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG4.9381e-060.3312image
ENSG00000147133.14,TAF1PAADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.4289e-030.3193image
ENSG00000147133.14,TAF1PCPGGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG5.0551e-04-0.3399image
ENSG00000147133.14,TAF1PRADGSVA_HALLMARK_BILE_ACID_METABOLISMEAG9.5249e-03-0.1857image
ENSG00000147133.14,TAF1READGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.9485e-04-0.6675image
ENSG00000147133.14,TAF1SARCGSVA_HALLMARK_MYOGENESISEAG5.3649e-04-0.3029image
ENSG00000147133.14,TAF1SKCMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG7.7385e-050.3371image
ENSG00000147133.14,TAF1STADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG3.3281e-06-0.3004image
chrX:71411091-71412235:+STADGSVA_HALLMARK_MYC_TARGETS_V2EER6.8241e-030.2802image
chrX:71408368-71409440:+STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.0774e-020.4690image
ENSG00000147133.14,TAF1TGCTGSVA_HALLMARK_KRAS_SIGNALING_UPEAG3.4602e-04-0.4538image
ENSG00000147133.14,TAF1THCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG9.0508e-030.1546image
ENSG00000147133.14,TAF1THYMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.3634e-020.4316image
ENSG00000147133.14,TAF1UCECGSVA_HALLMARK_ANDROGEN_RESPONSEEAG2.2938e-04-0.3751image
ENSG00000147133.14,TAF1UCSGSVA_HALLMARK_GLYCOLYSISEAG9.4936e-03-0.4384image


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7. Enriched editing regions and drugs for TAF1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000147133.14,TAF1BLCACGP.60474EAG5.5339e-03-0.1926image
ENSG00000147133.14,TAF1BRCACMKEAG4.6164e-04-0.1350image
ENSG00000147133.14,TAF1CESCErlotinibEAG2.4349e-02-0.2218image
ENSG00000147133.14,TAF1COADBMS.509744EAG6.1100e-080.5642image
ENSG00000147133.14,TAF1ESCAJNK.Inhibitor.VIIIEAG2.7698e-020.2159image
ENSG00000147133.14,TAF1GBMAZ628EAG1.5344e-03-0.5613image
ENSG00000147133.14,TAF1HNSCEpothilone.BEAG5.0511e-030.2445image
ENSG00000147133.14,TAF1KIRCBexaroteneEAG6.3965e-040.2639image
ENSG00000147133.14,TAF1KIRPErlotinibEAG2.3082e-02-0.3728image
chrX:71411091-71412235:+LAMLErlotinibEER1.1879e-020.2733image
ENSG00000147133.14,TAF1LGGBI.D1870EAG3.1839e-020.1703image
ENSG00000147133.14,TAF1LIHCAZD7762EAG1.8708e-04-0.3065image
ENSG00000147133.14,TAF1LUADA.770041EAG5.6809e-04-0.1959image
ENSG00000147133.14,TAF1LUSCIPA.3EAG8.6953e-04-0.2205image
ENSG00000147133.14,TAF1MESOCHIR.99021EAG1.0289e-02-0.4168image
ENSG00000147133.14,TAF1OVEmbelinEAG1.5820e-050.3140image
ENSG00000147133.14,TAF1PAADBosutinibEAG5.9375e-030.2911image
ENSG00000147133.14,TAF1PCPGAUY922EAG7.0190e-040.3317image
ENSG00000147133.14,TAF1PRADCCT007093EAG1.1504e-03-0.2317image
ENSG00000147133.14,TAF1READBMS.708163EAG2.8266e-030.5617image
ENSG00000147133.14,TAF1SARCABT.888EAG1.5789e-03-0.2776image
ENSG00000147133.14,TAF1SKCMDasatinibEAG5.4296e-05-0.3463image
chrX:71411091-71412235:+STADAG.014699EER6.1365e-030.2837image
chrX:71416257-71417668:+STADAZD6244EER2.0394e-02-0.2850image
chrX:71408368-71409440:+STADA.443654EER9.9803e-03-0.5152image
ENSG00000147133.14,TAF1TGCTAMG.706EAG8.3622e-030.3432image
ENSG00000147133.14,TAF1THCAAZD6244EAG3.2940e-04-0.2123image
ENSG00000147133.14,TAF1THYMEmbelinEAG3.5518e-040.5923image
ENSG00000147133.14,TAF1UCECGDC.0449EAG1.7477e-04-0.3816image
ENSG00000147133.14,TAF1UCSBosutinibEAG1.0752e-02-0.4319image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType