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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: SULT1A1 (ImmuneEditome ID:6817)

1. Gene summary of enriched editing regions for SULT1A1

check button Gene summary
Gene informationGene symbol

SULT1A1

Gene ID

6817

GeneSynonymsHAST1/HAST2|P-PST|P-PST 1|PST|ST1A1|ST1A3|STP|STP1|TSPST1|ts-PST
GeneCytomap

16p11.2

GeneTypeprotein-coding
GeneDescriptionsulfotransferase 1A1|aryl sulfotransferase 1|phenol-sulfating phenol sulfotransferase 1|sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1|thermostable phenol sulfotransferase1
GeneModificationdate20230518
UniprotIDP50225;H3BRY5;H3BQX5
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr16:28608041-28608308:-ENST00000314752.10ENSG00000196502.10SULT1A1exonicAluSpchr16:28608041-28608308:-.alignment
chr16:28608041-28608308:-ENST00000395607.4ENSG00000196502.10SULT1A1exonicAluSpchr16:28608041-28608308:-.alignment
chr16:28608041-28608308:-ENST00000395609.4ENSG00000196502.10SULT1A1exonicAluSpchr16:28608041-28608308:-.alignment
chr16:28608041-28608308:-ENST00000566189.4ENSG00000196502.10SULT1A1exonicAluSpchr16:28608041-28608308:-.alignment
chr16:28608041-28608308:-ENST00000567512.1ENSG00000196502.10SULT1A1exonicAluSpchr16:28608041-28608308:-.alignment
chr16:28608041-28608308:-ENST00000569554.4ENSG00000196502.10SULT1A1exonicAluSpchr16:28608041-28608308:-.alignment
chr16:28609505-28609724:-ENST00000567998.4ENSG00000196502.10SULT1A1ncRNA_exonicAluJr4chr16:28609505-28609724:-.alignment
chr16:28617040-28619731:-ENST00000350842.7ENSG00000196502.10SULT1A1intronicAluSz,AluJb,LTR84a,AluSc,L2c,AluSc8chr16:28617040-28619731:-.alignment
chr16:28617040-28619731:-ENST00000395609.4ENSG00000196502.10SULT1A1intronicAluSz,AluJb,LTR84a,AluSc,L2c,AluSc8chr16:28617040-28619731:-.alignment
chr16:28617040-28619731:-ENST00000562058.4ENSG00000196502.10SULT1A1intronicAluSz,AluJb,LTR84a,AluSc,L2c,AluSc8chr16:28617040-28619731:-.alignment
chr16:28617040-28619731:-ENST00000563493.1ENSG00000196502.10SULT1A1intronicAluSz,AluJb,LTR84a,AluSc,L2c,AluSc8chr16:28617040-28619731:-.alignment
chr16:28617040-28619731:-ENST00000564818.4ENSG00000196502.10SULT1A1intronicAluSz,AluJb,LTR84a,AluSc,L2c,AluSc8chr16:28617040-28619731:-.alignment


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2. Tumor-specific enriched editing regions for SULT1A1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
ENSG00000196502.10,SULT1A1BRCAEAG6.6382e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for SULT1A1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for SULT1A1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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5. Enriched editing regions and immune infiltration for SULT1A1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000196502.10,SULT1A1BLCAEAGMacrophages_M28.4266e-03-0.3318image
chr16:28617040-28619731:-BRCAEERMacrophages_M12.4541e-020.2482image
ENSG00000196502.10,SULT1A1COADEAGT_cells_CD4_naive1.9245e-020.4841image
chr16:28617040-28619731:-ESCAEERB_cells_naive3.3427e-020.3177image
ENSG00000196502.10,SULT1A1KIRCEAGDendritic_cells_activated7.5854e-030.4500image
ENSG00000196502.10,SULT1A1KIRPEAGMast_cells_activated5.1179e-040.5874image
ENSG00000196502.10,SULT1A1LAMLEAGT_cells_regulatory_(Tregs)8.3397e-03-0.2587image
ENSG00000196502.10,SULT1A1LUSCEAGT_cells_CD4_memory_resting3.0163e-020.2238image
chr16:28609505-28609724:-OVEERT_cells_follicular_helper4.2088e-02-0.1814image
ENSG00000196502.10,SULT1A1OVEAGEosinophils2.3243e-02-0.1846image
chr16:28609505-28609724:-PCPGEERMast_cells_resting1.6486e-030.6307image
chr16:28617040-28619731:-STADEERPlasma_cells4.5912e-020.2609image
ENSG00000196502.10,SULT1A1STADEAGB_cells_memory4.5803e-020.2044image
ENSG00000196502.10,SULT1A1THCAEAGB_cells_memory4.4646e-02-0.1648image


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6. Enriched editing regions and immune gene sets for SULT1A1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000196502.10,SULT1A1BLCAEAG7.8792e-030.33455.4746e-030.34873.0958e-040.44323.7601e-030.3628image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000196502.10,SULT1A1BLCAGSVA_HALLMARK_P53_PATHWAYEAG1.0365e-030.4067image
chr16:28617040-28619731:-BRCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER5.4680e-030.3041image
ENSG00000196502.10,SULT1A1BRCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG9.6326e-070.2460image
chr16:28608041-28608308:-BRCAGSVA_HALLMARK_ADIPOGENESISEER1.4994e-040.4565image
ENSG00000196502.10,SULT1A1CESCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG4.3437e-030.5314image
ENSG00000196502.10,SULT1A1COADGSVA_HALLMARK_COAGULATIONEAG1.5958e-020.4965image
chr16:28617040-28619731:-ESCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER5.9365e-04-0.4922image
ENSG00000196502.10,SULT1A1ESCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.1787e-020.3130image
ENSG00000196502.10,SULT1A1KIRCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG4.0473e-020.3532image
ENSG00000196502.10,SULT1A1LUADGSVA_HALLMARK_BILE_ACID_METABOLISMEAG3.7913e-02-0.2561image
ENSG00000196502.10,SULT1A1LUSCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG1.7826e-020.2439image
chr16:28617040-28619731:-OVGSVA_HALLMARK_HEME_METABOLISMEER1.0772e-020.3097image
chr16:28609505-28609724:-OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.7218e-020.2119image
chr16:28608041-28608308:-OVGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER3.2272e-020.4209image
ENSG00000196502.10,SULT1A1OVGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG4.6178e-020.1625image
chr16:28609505-28609724:-PCPGGSVA_HALLMARK_SPERMATOGENESISEER7.3585e-030.5548image
ENSG00000196502.10,SULT1A1PRADGSVA_HALLMARK_UV_RESPONSE_DNEAG2.2121e-020.2975image
ENSG00000196502.10,SULT1A1THCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG3.7222e-050.3311image


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7. Enriched editing regions and drugs for SULT1A1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000196502.10,SULT1A1BLCACGP.60474EAG5.9816e-03-0.3453image
chr16:28617040-28619731:-BRCACCT018159EER2.5440e-020.2467image
ENSG00000196502.10,SULT1A1BRCALapatinibEAG3.7780e-03-0.1477image
ENSG00000196502.10,SULT1A1COADDasatinibEAG6.9884e-03-0.5464image
chr16:28617040-28619731:-ESCAFH535EER2.0722e-050.5891image
ENSG00000196502.10,SULT1A1ESCAFH535EAG4.5736e-060.5379image
ENSG00000196502.10,SULT1A1KIRCAZD6482EAG1.6560e-02-0.4082image
ENSG00000196502.10,SULT1A1KIRPCGP.082996EAG2.8131e-020.3944image
ENSG00000196502.10,SULT1A1LAMLABT.263EAG1.5530e-03-0.3080image
ENSG00000196502.10,SULT1A1LUADKIN001.135EAG1.9213e-04-0.4434image
ENSG00000196502.10,SULT1A1LUSCLFM.A13EAG1.2396e-02-0.2570image
chr16:28609505-28609724:-OVMG.132EER3.2976e-03-0.2609image
chr16:28608041-28608308:-OVDasatinibEER7.1004e-03-0.5150image
ENSG00000196502.10,SULT1A1OVMG.132EAG2.6372e-02-0.1813image
chr16:28609505-28609724:-PCPGCHIR.99021EER2.2569e-050.7753image
ENSG00000196502.10,SULT1A1PCPGCHIR.99021EAG1.5181e-020.4192image
chr16:28617040-28619731:-STADFH535EER1.9876e-020.3025image
ENSG00000196502.10,SULT1A1THCALapatinibEAG8.4377e-04-0.2706image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType