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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: STK4 (ImmuneEditome ID:6789)

1. Gene summary of enriched editing regions for STK4

check button Gene summary
Gene informationGene symbol

STK4

Gene ID

6789

GeneSynonymsKRS2|MST1|YSK3
GeneCytomap

20q13.12

GeneTypeprotein-coding
GeneDescriptionserine/threonine-protein kinase 4|STE20-like kinase MST1|hippo homolog|kinase responsive to stress 2|mammalian STE20-like protein kinase 1|mammalian sterile 20-like 1|serine/threonine-protein kinase Krs-2
GeneModificationdate20230329
UniprotIDQ13043;F5H5B4;A0A087WYT4
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr20:45030246-45030396:+ENST00000372801.4ENSG00000101109.10STK4intronicAluSg7chr20:45030246-45030396:+.alignment
chr20:45030246-45030396:+ENST00000372806.6ENSG00000101109.10STK4intronicAluSg7chr20:45030246-45030396:+.alignment
chr20:45030246-45030396:+ENST00000499879.5ENSG00000101109.10STK4intronicAluSg7chr20:45030246-45030396:+.alignment
chr20:45077435-45079253:+ENST00000372806.6ENSG00000101109.10STK4UTR3(GTT)n,AluJb,(TGGA)n,AluSq2,AluSx4,L1ME3Achr20:45077435-45079253:+.alignment
chr20:45077435-45079253:+ENST00000499879.5ENSG00000101109.10STK4UTR3(GTT)n,AluJb,(TGGA)n,AluSq2,AluSx4,L1ME3Achr20:45077435-45079253:+.alignment


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2. Tumor-specific enriched editing regions for STK4


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr20:45077435-45079253:+BRCAEER8.7995e-03image
ENSG00000101109.10,STK4BRCAEAG5.6332e-03image
chr20:45077435-45079253:+COADEER4.4558e-06image
ENSG00000101109.10,STK4COADEAG9.4433e-07image
chr20:45077435-45079253:+HNSCEER1.2047e-04image
ENSG00000101109.10,STK4HNSCEAG1.2047e-04image
chr20:45077435-45079253:+KICHEER6.7656e-03image
ENSG00000101109.10,STK4KICHEAG6.7656e-03image
chr20:45077435-45079253:+LUADEER2.2451e-03image
ENSG00000101109.10,STK4LUADEAG1.8340e-03image
chr20:45077435-45079253:+LUSCEER2.7556e-04image
ENSG00000101109.10,STK4LUSCEAG3.0448e-04image
chr20:45077435-45079253:+UCECEER2.5304e-02image
ENSG00000101109.10,STK4UCECEAG2.3927e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr20:45077435-45079253:+CHOLPathEER4.7961e-022.8065e-020.3768image
ENSG00000101109.10,STK4CHOLPathEAG4.7961e-022.8065e-020.3768image
ENSG00000101109.10,STK4KIRCPathEAG4.4839e-063.9982e-050.1776image
chr20:45077435-45079253:+KIRCPathEER9.7954e-068.0902e-060.1928image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for STK4


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr20:45077435-45079253:+COADEERENSG00000272440,RP11-379F4.60.18483.7472e-022.7820e-200.5196imageNNNAEosinophilsGSVA_HALLMARK_HEME_METABOLISM
chr20:45077435-45079253:+UCECEERENSG00000111678,C12orf570.25114.8027e-029.2453e-190.6122imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr20:45077435-45079253:+PCPGEERENSG00000260428,SCX0.28956.0102e-039.2432e-110.4600imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HEDGEHOG_SIGNALING
chr20:45077435-45079253:+PCPGEERENSG00000185615,PDIA20.25991.8874e-025.6668e-150.5406imageNNPDIA2Plasma_cellsGSVA_HALLMARK_ANDROGEN_RESPONSE
chr20:45077435-45079253:+PCPGEERENSG00000148384,INPP5E0.23503.9047e-024.0179e-090.4220imageNNNAGSVA_HALLMARK_HYPOXIA
chr20:45077435-45079253:+PCPGEERENSG00000178026,LRRC75B0.22874.7340e-022.8232e-080.4003imageNNNAPlasma_cellsGSVA_HALLMARK_UV_RESPONSE_DN
chr20:45077435-45079253:+UVMEERENSG00000102030,NAA100.39111.7330e-021.9499e-040.4200imageNNNANeutrophilsGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr20:45077435-45079253:+UVMEERENSG00000175416,CLTB0.37672.2300e-022.6620e-040.4119imageNNNAEosinophilsGSVA_HALLMARK_KRAS_SIGNALING_DN
chr20:45077435-45079253:+READEERENSG00000187164,KIAA1598-0.45523.4579e-029.8244e-06-0.4364imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_G2M_CHECKPOINT
chr20:45077435-45079253:+COADEERENSG00000272440,RP11-379F4.60.18483.7472e-022.7820e-200.5196imageNNNAEosinophilsGSVA_HALLMARK_HEME_METABOLISM
chr20:45077435-45079253:+UCECEERENSG00000111678,C12orf570.25114.8027e-029.2453e-190.6122imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr20:45077435-45079253:+PCPGEERENSG00000260428,SCX0.28956.0102e-039.2432e-110.4600imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HEDGEHOG_SIGNALING
chr20:45077435-45079253:+PCPGEERENSG00000185615,PDIA20.25991.8874e-025.6668e-150.5406imageNNPDIA2Plasma_cellsGSVA_HALLMARK_ANDROGEN_RESPONSE
chr20:45077435-45079253:+PCPGEERENSG00000148384,INPP5E0.23503.9047e-024.0179e-090.4220imageNNNAGSVA_HALLMARK_HYPOXIA
chr20:45077435-45079253:+PCPGEERENSG00000178026,LRRC75B0.22874.7340e-022.8232e-080.4003imageNNNAPlasma_cellsGSVA_HALLMARK_UV_RESPONSE_DN
chr20:45077435-45079253:+UVMEERENSG00000102030,NAA100.39111.7330e-021.9499e-040.4200imageNNNANeutrophilsGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr20:45077435-45079253:+UVMEERENSG00000175416,CLTB0.37672.2300e-022.6620e-040.4119imageNNNAEosinophilsGSVA_HALLMARK_KRAS_SIGNALING_DN
chr20:45077435-45079253:+READEERENSG00000187164,KIAA1598-0.45523.4579e-029.8244e-06-0.4364imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_G2M_CHECKPOINT

More results



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4. Enriched editing regions and immune related splicing for STK4


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000101109.10,STK4
COADEAGMEXENSG00000169826.6chr1043154896:43155810:43158714:43158931:43163865:43164044:43167003:431670980.22842.6997e-022.3476e-140.4437imageNACIN1;ADAR;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LIN28;LIN28A;LIN28B;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM47;RNF219;SAFB2;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;ZNF184NAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000101109.10,STK4
COADEAGIRENSG00000083312.13chr572872638:72872720:72875614:728757370.20324.1314e-025.3529e-270.5927imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL14;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RBM6;RC3H1;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000101109.10,STK4
COADEAGIRENSG00000070476.10chr3126439631:126459737:126461534:1264622200.22214.1408e-026.1308e-140.4314imageNADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RC3H1;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAEosinophilsGSVA_HALLMARK_DNA_REPAIR
ENSG00000101109.10,STK4
COADEAGIRENSG00000120533.8chr8109334323:109334402:109336127:1093362040.21754.8182e-022.8323e-120.4042imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;RNF219;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000101109.10,STK4
COADEAGMEXENSG00000110700.2chr1117075096:17075197:17075453:17075491:17075588:17075623:17077167:170772460.27303.3907e-033.5252e-180.4913imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL14;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YWHAG;ZNF184NADendritic_cells_activatedGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
ENSG00000101109.10,STK4
COADEAGMEXENSG00000161016.11chr8144790354:144790470:144791276:144791307:144791772:144791914:144791991:1447920570.26096.9448e-031.1506e-160.4713imageNACIN1;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;METTL3;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RBM6;RC3H1;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAEosinophilsGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
ENSG00000101109.10,STK4
COADEAGIRENSG00000105856.9chr7107200159:107200301:107201413:1072014540.23462.1474e-023.5195e-210.5284imageNACIN1;ADAR;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RTCB;SAFB2;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YWHAG;ZC3H7B;ZNF184NAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000101109.10,STK4
COADEAGIRENSG00000160218.8chr2144082787:44083302:44084121:440842630.28511.0630e-032.7360e-190.5109imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL14;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;RTCB;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NADendritic_cells_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000101109.10,STK4
COADEAGIRENSG00000059804.11chr127929503:7930642:7931244:79314850.19702.1475e-021.3851e-230.6259imageNADAR;ALYREF;AUH;BCCIP;BUD13;CELF2;CPSF6;CSTF2T;DDX3X;DDX42;DGCR8;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;PCBP2;PRPF8;PTBP1;RBFOX2;RBM22;RBM27;RBM47;RBM5;SAFB2;SF3A3;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAGNAMast_cells_activatedGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000101109.10,STK4
COADEAGMEXENSG00000110700.2chr1117075096:17075197:17075453:17075572:17075588:17075623:17077167:170772460.27293.4421e-034.9604e-180.4894imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL14;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YWHAG;ZNF184NADendritic_cells_activatedGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING

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5. Enriched editing regions and immune infiltration for STK4


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr20:45077435-45079253:+ACCEERMast_cells_activated1.8333e-020.2682image
ENSG00000101109.10,STK4ACCEAGMast_cells_activated5.6602e-030.3125image
chr20:45077435-45079253:+BLCAEERT_cells_CD4_naive1.3880e-04-0.1889image
ENSG00000101109.10,STK4BLCAEAGMacrophages_M26.2107e-050.1979image
chr20:45077435-45079253:+BRCAEERNK_cells_activated1.3414e-020.0752image
ENSG00000101109.10,STK4BRCAEAGNK_cells_activated4.7644e-030.0858image
chr20:45077435-45079253:+CESCEERT_cells_CD4_memory_activated2.1135e-020.1335image
ENSG00000101109.10,STK4CESCEAGT_cells_CD4_memory_activated2.1124e-020.1335image
chr20:45077435-45079253:+COADEERDendritic_cells_activated9.3441e-030.1570image
ENSG00000101109.10,STK4COADEAGDendritic_cells_activated1.2368e-040.2290image
ENSG00000101109.10,STK4DLBCEAGMacrophages_M22.8577e-020.3162image
chr20:45077435-45079253:+ESCAEERT_cells_regulatory_(Tregs)5.9443e-07-0.3815image
ENSG00000101109.10,STK4ESCAEAGT_cells_regulatory_(Tregs)1.2753e-06-0.3709image
chr20:45077435-45079253:+GBMEERT_cells_CD4_memory_resting3.0947e-020.1670image
ENSG00000101109.10,STK4GBMEAGT_cells_CD4_memory_resting2.2952e-020.1759image
chr20:45077435-45079253:+HNSCEERPlasma_cells3.5860e-04-0.1606image
ENSG00000101109.10,STK4HNSCEAGPlasma_cells3.5860e-04-0.1606image
chr20:45077435-45079253:+KIRCEERT_cells_CD4_memory_activated3.3975e-030.1497image
ENSG00000101109.10,STK4KIRCEAGT_cells_CD4_memory_activated1.4941e-020.1244image
chr20:45077435-45079253:+KIRPEERNeutrophils2.1568e-02-0.1370image
ENSG00000101109.10,STK4KIRPEAGNeutrophils2.1568e-02-0.1370image
chr20:45077435-45079253:+LAMLEERMast_cells_activated2.7729e-030.2426image
ENSG00000101109.10,STK4LAMLEAGT_cells_CD4_memory_activated3.5558e-020.1718image
chr20:45077435-45079253:+LGGEERMacrophages_M27.7404e-040.1459image
ENSG00000101109.10,STK4LGGEAGMacrophages_M29.2567e-040.1437image
chr20:45077435-45079253:+LIHCEERT_cells_CD4_memory_activated1.4101e-02-0.1313image
ENSG00000101109.10,STK4LIHCEAGT_cells_CD4_memory_activated2.5142e-02-0.1197image
chr20:45077435-45079253:+LUADEERDendritic_cells_activated3.2747e-050.1825image
ENSG00000101109.10,STK4LUADEAGDendritic_cells_activated2.3229e-050.1856image
chr20:45077435-45079253:+LUSCEERDendritic_cells_activated1.7731e-020.1063image
ENSG00000101109.10,STK4LUSCEAGDendritic_cells_activated1.8166e-020.1059image
chr20:45077435-45079253:+MESOEERT_cells_CD4_naive2.1125e-02-0.2559image
ENSG00000101109.10,STK4MESOEAGT_cells_CD4_naive2.1125e-02-0.2559image
chr20:45077435-45079253:+OVEERMacrophages_M18.4232e-030.1547image
ENSG00000101109.10,STK4OVEAGMacrophages_M19.7000e-030.1519image
chr20:45077435-45079253:+PAADEERT_cells_follicular_helper2.3635e-020.1710image
ENSG00000101109.10,STK4PAADEAGT_cells_follicular_helper2.3635e-020.1710image
chr20:45077435-45079253:+PCPGEERPlasma_cells2.1188e-020.1722image
ENSG00000101109.10,STK4PCPGEAGPlasma_cells2.1188e-020.1722image
ENSG00000101109.10,STK4PRADEAGT_cells_CD4_memory_resting3.2752e-020.0963image
chr20:45077435-45079253:+READEERT_cells_CD4_memory_activated1.2207e-03-0.3270image
ENSG00000101109.10,STK4READEAGT_cells_CD4_memory_activated1.2035e-04-0.3843image
chr20:45077435-45079253:+SARCEERT_cells_CD4_memory_resting1.7152e-020.1492image
ENSG00000101109.10,STK4SARCEAGT_cells_CD4_memory_resting1.7152e-020.1492image
chr20:45077435-45079253:+SKCMEERPlasma_cells7.8095e-040.1546image
ENSG00000101109.10,STK4SKCMEAGPlasma_cells7.4375e-040.1552image
chr20:45077435-45079253:+STADEERT_cells_CD4_naive6.2942e-03-0.1422image
ENSG00000101109.10,STK4STADEAGT_cells_CD4_naive3.4757e-03-0.1520image
chr20:45077435-45079253:+TGCTEERMacrophages_M26.3121e-03-0.2199image
ENSG00000101109.10,STK4TGCTEAGMacrophages_M26.3121e-03-0.2199image
chr20:45077435-45079253:+THCAEERT_cells_follicular_helper2.6066e-020.0996image
ENSG00000101109.10,STK4THCAEAGT_cells_follicular_helper2.6066e-020.0996image
chr20:45077435-45079253:+THYMEERT_cells_CD4_naive2.6825e-04-0.3365image
ENSG00000101109.10,STK4THYMEAGT_cells_CD4_naive2.6825e-04-0.3365image
chr20:45077435-45079253:+UCECEERT_cells_regulatory_(Tregs)4.3400e-020.1556image
ENSG00000101109.10,STK4UCECEAGT_cells_regulatory_(Tregs)3.0214e-020.1663image
chr20:45077435-45079253:+UCSEERT_cells_regulatory_(Tregs)3.6463e-020.2828image
ENSG00000101109.10,STK4UCSEAGT_cells_regulatory_(Tregs)3.6463e-020.2828image
chr20:45077435-45079253:+UVMEERT_cells_regulatory_(Tregs)2.9244e-020.2536image
ENSG00000101109.10,STK4UVMEAGT_cells_regulatory_(Tregs)2.9244e-020.2536image


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6. Enriched editing regions and immune gene sets for STK4


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000101109.10,STK4BLCAEAG6.0725e-040.16982.9366e-020.10841.8508e-030.15442.2519e-030.1516image
chr20:45077435-45079253:+BLCAEER1.7397e-040.18621.8613e-020.11738.3176e-040.16604.1149e-040.1754image
ENSG00000101109.10,STK4COADEAG2.2892e-03-0.18291.4852e-03-0.19046.2377e-05-0.23861.4784e-02-0.1466image
ENSG00000101109.10,STK4ESCAEAG2.2002e-060.36317.9951e-030.20842.4961e-070.39311.1154e-050.3386image
chr20:45077435-45079253:+ESCAEER3.9938e-070.38694.2220e-030.22443.7306e-080.41701.0891e-050.3390image
chr20:45077435-45079253:+LUADEER3.2803e-050.18242.6538e-050.18451.8899e-040.16431.7531e-020.1049image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000101109.10,STK4ACCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.4981e-020.2554image
chr20:45077435-45079253:+ACCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.6696e-020.2526image
ENSG00000101109.10,STK4BLCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG5.6998e-060.2236image
chr20:45077435-45079253:+BLCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER9.5049e-070.2416image
ENSG00000101109.10,STK4BRCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG3.7770e-06-0.1402image
chr20:45077435-45079253:+BRCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.5264e-04-0.1150image
chr20:45077435-45079253:+CESCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.6551e-040.2165image
ENSG00000101109.10,STK4CESCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.6474e-040.2166image
chr20:45077435-45079253:+CHOLGSVA_HALLMARK_SPERMATOGENESISEER4.2567e-02-0.3498image
ENSG00000101109.10,STK4CHOLGSVA_HALLMARK_SPERMATOGENESISEAG4.2567e-02-0.3498image
chr20:45077435-45079253:+COADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER1.5626e-04-0.2269image
ENSG00000101109.10,STK4COADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG9.7717e-09-0.3366image
ENSG00000101109.10,STK4DLBCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG3.2498e-020.3092image
ENSG00000101109.10,STK4ESCAGSVA_HALLMARK_HYPOXIAEAG1.1154e-050.3386image
chr20:45077435-45079253:+ESCAGSVA_HALLMARK_MTORC1_SIGNALINGEER9.1870e-060.3416image
ENSG00000101109.10,STK4GBMGSVA_HALLMARK_MYOGENESISEAG3.1133e-020.1669image
chr20:45077435-45079253:+GBMGSVA_HALLMARK_MYOGENESISEER4.1588e-020.1579image
ENSG00000101109.10,STK4HNSCGSVA_HALLMARK_HYPOXIAEAG2.6414e-030.1356image
chr20:45077435-45079253:+HNSCGSVA_HALLMARK_HYPOXIAEER2.6414e-030.1356image
ENSG00000101109.10,STK4KIRCGSVA_HALLMARK_KRAS_SIGNALING_DNEAG4.5609e-02-0.1023image
chr20:45077435-45079253:+KIRCGSVA_HALLMARK_E2F_TARGETSEER1.9220e-020.1199image
ENSG00000101109.10,STK4KIRPGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.6013e-030.1874image
chr20:45077435-45079253:+KIRPGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.6013e-030.1874image
chr20:45077435-45079253:+LAMLGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.8440e-030.2347image
ENSG00000101109.10,STK4LAMLGSVA_HALLMARK_SPERMATOGENESISEAG4.6442e-03-0.2300image
ENSG00000101109.10,STK4LGGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.6273e-080.2427image
chr20:45077435-45079253:+LGGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.1458e-080.2379image
ENSG00000101109.10,STK4LIHCGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.4317e-03-0.1616image
chr20:45077435-45079253:+LIHCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER3.5942e-030.1555image
chr20:45077435-45079253:+LUADGSVA_HALLMARK_GLYCOLYSISEER1.2784e-050.1915image
ENSG00000101109.10,STK4LUADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.7305e-04-0.1651image
ENSG00000101109.10,STK4LUSCGSVA_HALLMARK_MTORC1_SIGNALINGEAG5.9445e-050.1791image
chr20:45077435-45079253:+LUSCGSVA_HALLMARK_MTORC1_SIGNALINGEER5.4962e-050.1799image
chr20:45077435-45079253:+MESOGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER3.2471e-020.2379image
ENSG00000101109.10,STK4MESOGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG3.2471e-020.2379image
ENSG00000101109.10,STK4OVGSVA_HALLMARK_COAGULATIONEAG2.1216e-080.3221image
chr20:45077435-45079253:+OVGSVA_HALLMARK_COAGULATIONEER1.7938e-080.3237image
ENSG00000101109.10,STK4PAADGSVA_HALLMARK_E2F_TARGETSEAG3.3321e-020.1610image
chr20:45077435-45079253:+PAADGSVA_HALLMARK_E2F_TARGETSEER3.3321e-020.1610image
ENSG00000101109.10,STK4PCPGGSVA_HALLMARK_GLYCOLYSISEAG5.3306e-05-0.2972image
chr20:45077435-45079253:+PCPGGSVA_HALLMARK_GLYCOLYSISEER5.3306e-05-0.2972image
chr20:45077435-45079253:+PRADGSVA_HALLMARK_COAGULATIONEER4.5653e-050.1827image
ENSG00000101109.10,STK4PRADGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG1.2804e-040.1718image
ENSG00000101109.10,STK4READGSVA_HALLMARK_PEROXISOMEEAG6.3268e-03-0.2783image
chr20:45077435-45079253:+READGSVA_HALLMARK_PEROXISOMEEER1.1615e-02-0.2579image
ENSG00000101109.10,STK4SKCMGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.5362e-04-0.1613image
chr20:45077435-45079253:+SKCMGSVA_HALLMARK_MITOTIC_SPINDLEEER1.0321e-03-0.1511image
ENSG00000101109.10,STK4STADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.8592e-020.1141image
chr20:45077435-45079253:+STADGSVA_HALLMARK_UV_RESPONSE_UPEER2.7319e-030.1558image
chr20:45077435-45079253:+TGCTGSVA_HALLMARK_MITOTIC_SPINDLEEER3.2590e-04-0.2868image
ENSG00000101109.10,STK4TGCTGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.2590e-04-0.2868image
ENSG00000101109.10,STK4THCAGSVA_HALLMARK_MTORC1_SIGNALINGEAG4.1228e-040.1575image
chr20:45077435-45079253:+THCAGSVA_HALLMARK_MTORC1_SIGNALINGEER4.1228e-040.1575image
ENSG00000101109.10,STK4THYMGSVA_HALLMARK_G2M_CHECKPOINTEAG1.9944e-02-0.2187image
chr20:45077435-45079253:+THYMGSVA_HALLMARK_G2M_CHECKPOINTEER1.9944e-02-0.2187image
chr20:45077435-45079253:+UCECGSVA_HALLMARK_MITOTIC_SPINDLEEER2.7803e-03-0.2287image
ENSG00000101109.10,STK4UCECGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.0872e-03-0.2345image
chr20:45077435-45079253:+UCSGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER2.8318e-020.2958image
ENSG00000101109.10,STK4UCSGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG2.8318e-020.2958image


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7. Enriched editing regions and drugs for STK4


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000101109.10,STK4ACCBryostatin.1EAG2.4796e-02-0.2557image
chr20:45077435-45079253:+ACCGDC0941EER1.7003e-02-0.2713image
chr20:45077435-45079253:+BLCAKU.55933EER1.2238e-07-0.2601image
ENSG00000101109.10,STK4BLCAKU.55933EAG8.1995e-07-0.2424image
ENSG00000101109.10,STK4BRCAAS601245EAG5.4668e-030.0845image
chr20:45077435-45079253:+BRCAAS601245EER1.0787e-030.0994image
chr20:45077435-45079253:+CESCAZD.2281EER6.0857e-03-0.1586image
ENSG00000101109.10,STK4CESCAZD.2281EAG6.0803e-03-0.1586image
ENSG00000101109.10,STK4CHOLAZD6244EAG3.4104e-020.3644image
chr20:45077435-45079253:+CHOLAZD6244EER3.4104e-020.3644image
chr20:45077435-45079253:+COADBMS.708163EER3.5197e-03-0.1761image
ENSG00000101109.10,STK4COADGW843682XEAG1.9734e-090.3512image
ENSG00000101109.10,STK4DLBCCHIR.99021EAG3.3962e-03-0.4145image
chr20:45077435-45079253:+ESCACMKEER1.0063e-04-0.3017image
ENSG00000101109.10,STK4ESCACGP.60474EAG3.7436e-05-0.3189image
chr20:45077435-45079253:+GBMMetforminEER4.7217e-03-0.2176image
ENSG00000101109.10,STK4GBMMetforminEAG4.9206e-03-0.2166image
chr20:45077435-45079253:+HNSCGNF.2EER3.0138e-03-0.1342image
ENSG00000101109.10,STK4HNSCGNF.2EAG3.0138e-03-0.1342image
ENSG00000101109.10,STK4KIRCAS601245EAG1.2507e-030.1645image
chr20:45077435-45079253:+KIRCCyclopamineEER3.0126e-04-0.1847image
ENSG00000101109.10,STK4KIRPGNF.2EAG2.1465e-04-0.2191image
chr20:45077435-45079253:+KIRPGNF.2EER2.1465e-04-0.2191image
ENSG00000101109.10,STK4LAMLCytarabineEAG8.2986e-030.2148image
chr20:45077435-45079253:+LAMLAZ628EER6.0879e-03-0.2230image
chr20:45077435-45079253:+LGGMG.132EER7.8837e-07-0.2129image
ENSG00000101109.10,STK4LGGMG.132EAG5.8977e-07-0.2153image
ENSG00000101109.10,STK4LIHCBryostatin.1EAG1.5821e-06-0.2533image
chr20:45077435-45079253:+LIHCBryostatin.1EER2.8051e-05-0.2222image
ENSG00000101109.10,STK4LUADCMKEAG6.7546e-04-0.1496image
chr20:45077435-45079253:+LUADErlotinibEER1.0973e-03-0.1439image
chr20:45077435-45079253:+LUSCAZD6482EER7.9186e-040.1500image
ENSG00000101109.10,STK4LUSCAZD6482EAG7.3494e-040.1510image
chr20:45077435-45079253:+MESODMOGEER2.3934e-030.3329image
ENSG00000101109.10,STK4MESODMOGEAG2.3934e-030.3329image
chr20:45077435-45079253:+OVGNF.2EER3.6735e-05-0.2402image
ENSG00000101109.10,STK4OVGNF.2EAG3.5705e-05-0.2406image
ENSG00000101109.10,STK4PAADMetforminEAG6.7542e-040.2546image
chr20:45077435-45079253:+PAADMetforminEER6.7542e-040.2546image
ENSG00000101109.10,STK4PCPGFTI.277EAG5.9481e-040.2542image
chr20:45077435-45079253:+PCPGFTI.277EER5.9481e-040.2542image
chr20:45077435-45079253:+PRADGNF.2EER3.6643e-05-0.1853image
ENSG00000101109.10,STK4PRADGNF.2EAG9.7801e-05-0.1751image
ENSG00000101109.10,STK4READCyclopamineEAG1.0856e-06-0.4783image
chr20:45077435-45079253:+READCyclopamineEER3.3680e-10-0.5918image
chr20:45077435-45079253:+SARCDMOGEER1.5517e-020.1514image
ENSG00000101109.10,STK4SARCDMOGEAG1.5517e-020.1514image
ENSG00000101109.10,STK4SKCMCMKEAG1.0116e-030.1513image
chr20:45077435-45079253:+SKCMCMKEER4.8543e-040.1605image
ENSG00000101109.10,STK4STADDocetaxelEAG4.5533e-05-0.2109image
chr20:45077435-45079253:+STADDocetaxelEER5.5918e-04-0.1790image
chr20:45077435-45079253:+TGCTGefitinibEER4.5964e-04-0.2798image
ENSG00000101109.10,STK4TGCTGefitinibEAG4.5964e-04-0.2798image
ENSG00000101109.10,STK4THCABMS.708163EAG4.3715e-03-0.1274image
chr20:45077435-45079253:+THCABMS.708163EER4.3715e-03-0.1274image
chr20:45077435-45079253:+THYMKIN001.135EER5.3224e-03-0.2605image
ENSG00000101109.10,STK4THYMKIN001.135EAG5.3224e-03-0.2605image
chr20:45077435-45079253:+UCECJNK.9LEER2.5017e-180.6061image
ENSG00000101109.10,STK4UCECJNK.9LEAG5.1716e-170.5853image
chr20:45077435-45079253:+UCSMetforminEER5.2257e-03-0.3715image
ENSG00000101109.10,STK4UCSMetforminEAG5.2257e-03-0.3715image
chr20:45077435-45079253:+UVMBMS.536924EER6.2949e-03-0.3148image
ENSG00000101109.10,STK4UVMBMS.536924EAG6.2949e-03-0.3148image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType