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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: SRP9 (ImmuneEditome ID:6726)

1. Gene summary of enriched editing regions for SRP9

check button Gene summary
Gene informationGene symbol

SRP9

Gene ID

6726

GeneSynonymsALURBP
GeneCytomap

1q42.12

GeneTypeprotein-coding
GeneDescriptionsignal recognition particle 9 kDa protein|signal recognition particle 9kD|signal recognition particle 9kDa
GeneModificationdate20230329
UniprotIDP49458;E9PE20;Q659G3;Q6P2S0;A0A024R3P3
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr1:225784576-225785857:+ENST00000304786.10ENSG00000143742.11SRP9intronicAluJr,AluSc,AluSz,AluYchr1:225784576-225785857:+.alignment
chr1:225784576-225785857:+ENST00000366838.1ENSG00000143742.11SRP9intronicAluJr,AluSc,AluSz,AluYchr1:225784576-225785857:+.alignment
chr1:225784576-225785857:+ENST00000366839.7ENSG00000143742.11SRP9intronicAluJr,AluSc,AluSz,AluYchr1:225784576-225785857:+.alignment
chr1:225784576-225785857:+ENST00000619790.3ENSG00000143742.11SRP9intronicAluJr,AluSc,AluSz,AluYchr1:225784576-225785857:+.alignment
chr1:225784576-225785857:+ENST00000626563.1ENSG00000143742.11SRP9intronicAluJr,AluSc,AluSz,AluYchr1:225784576-225785857:+.alignment
chr1:225786926-225788665:+ENST00000366839.7ENSG00000143742.11SRP9exonicAluSx1,AluSx,AluJo,AluSgchr1:225786926-225788665:+.alignment
chr1:225786926-225788665:+ENST00000619790.3ENSG00000143742.11SRP9exonicAluSx1,AluSx,AluJo,AluSgchr1:225786926-225788665:+.alignment


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2. Tumor-specific enriched editing regions for SRP9


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr1:225786926-225788665:+BRCAEER3.1830e-06image
ENSG00000143742.11,SRP9BRCAEAG3.5238e-06image
chr1:225786926-225788665:+KICHEER2.1345e-02image
ENSG00000143742.11,SRP9KICHEAG1.8540e-02image
chr1:225786926-225788665:+LIHCEER1.6941e-03image
ENSG00000143742.11,SRP9LIHCEAG1.6970e-03image
chr1:225786926-225788665:+LUADEER1.3016e-03image
ENSG00000143742.11,SRP9LUADEAG1.2142e-03image
chr1:225786926-225788665:+LUSCEER8.0182e-04image
ENSG00000143742.11,SRP9LUSCEAG9.9796e-04image
chr1:225786926-225788665:+THCAEER1.3603e-02image
ENSG00000143742.11,SRP9THCAEAG1.2870e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000143742.11,SRP9LIHCPathEAG4.1669e-023.4265e-020.1254image
chr1:225786926-225788665:+LIHCPathEER4.1822e-023.4394e-020.1254image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr1:225786926-225788665:+BRCAEER1.0769e-022.1571e-029.0612e+00image
ENSG00000143742.11,SRP9BRCAEAG1.0769e-022.3953e-028.7561e+00image
chr1:225786926-225788665:+LUSCEER6.0106e-032.8509e-051.4948e+01image
ENSG00000143742.11,SRP9LUSCEAG6.0106e-034.5972e-051.4482e+01image

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3. Enriched editing regions and immune related genes for SRP9


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr1:225786926-225788665:+KIRPEERENSG00000074356,C17orf850.38963.5212e-076.8551e-110.4297imageNELAVL1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;MSI1;NOP56;NOP58;PTBP1;RBFOX2;RBM47;SND1;U2AF2;UPF1;DDX54;ELAVL3;LIN28ANAT_cells_CD4_memory_restingGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr1:225786926-225788665:+KIRPEERENSG00000182796,TMEM198B0.37882.0512e-063.2022e-100.4156imageNNNAMast_cells_restingGSVA_HALLMARK_PANCREAS_BETA_CELLS
chr1:225786926-225788665:+ESCAEERENSG00000134333,LDHA0.31868.8330e-031.2721e-070.4041imageNELAVL1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;NOP56;NOP58;PTBP1;RBFOX2;RBM47;SND1;U2AF2;UPF1;DDX54;ELAVL3;LIN28ANAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr1:225786926-225788665:+ESCAEERENSG00000145107,TM4SF190.29021.8082e-021.2966e-090.4578imageNELAVL1;FUS;HNRNPK;IGF2BP2;NOP58;PTBP1;RBM47;SND1;U2AF2;UPF1NAT_cells_CD4_memory_restingGSVA_HALLMARK_P53_PATHWAY
chr1:225786926-225788665:+ESCAEERENSG00000119630,PGF0.27692.9065e-029.9654e-100.4607imageNELAVL1;FUS;HNRNPC;HNRNPK;MSI1;NOP56;RBFOX2;SND1;U2AF2PGFT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr1:225786926-225788665:+ESCAEERENSG00000072682,P4HA20.27213.4241e-029.0173e-110.4853imageNELAVL1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;MSI1;NOP56;NOP58;PTBP1;RBFOX2;RBM47;SND1;U2AF2;UPF1;DDX54;ELAVL3NAMacrophages_M0GSVA_HALLMARK_HYPOXIA
chr1:225786926-225788665:+ESCAEERENSG00000114450,GNB40.26274.2446e-021.9892e-080.4270imageNELAVL1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;MSI1;NOP56;NOP58;PTBP1;RBFOX2;RBM47;SND1;U2AF2;UPF1;DDX54;ELAVL3;LIN28ANAMacrophages_M1GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr1:225786926-225788665:+ESCAEERENSG00000235897,TM4SF19-AS10.25684.5333e-027.0176e-080.4116imageNELAVL1;FUS;HNRNPC;IGF2BP2;NOP56;NOP58;PTBP1;RBFOX2;U2AF2;UPF1NAT_cells_CD4_memory_restingGSVA_HALLMARK_BILE_ACID_METABOLISM
chr1:225786926-225788665:+PCPGEERENSG00000162139,NEU30.47221.9256e-062.9416e-090.4554imageNELAVL1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;NOP56;NOP58;PTBP1;RBFOX2;RBM47;SND1;U2AF2;UPF1;DDX54;ELAVL3;LIN28ANAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr1:225786926-225788665:+PCPGEERENSG00000172292,CERS60.46972.2360e-063.2845e-090.4542imageNELAVL1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;MSI1;NOP56;NOP58;PTBP1;RBFOX2;RBM47;SND1;U2AF2;UPF1;DDX54;ELAVL3;LIN28ANADendritic_cells_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr1:225786926-225788665:+KIRPEERENSG00000074356,C17orf850.38963.5212e-076.8551e-110.4297imageNELAVL1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;MSI1;NOP56;NOP58;PTBP1;RBFOX2;RBM47;SND1;U2AF2;UPF1;DDX54;ELAVL3;LIN28ANAT_cells_CD4_memory_restingGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr1:225786926-225788665:+KIRPEERENSG00000182796,TMEM198B0.37882.0512e-063.2022e-100.4156imageNNNAMast_cells_restingGSVA_HALLMARK_PANCREAS_BETA_CELLS
chr1:225786926-225788665:+ESCAEERENSG00000134333,LDHA0.31868.8330e-031.2721e-070.4041imageNELAVL1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;NOP56;NOP58;PTBP1;RBFOX2;RBM47;SND1;U2AF2;UPF1;DDX54;ELAVL3;LIN28ANAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr1:225786926-225788665:+ESCAEERENSG00000145107,TM4SF190.29021.8082e-021.2966e-090.4578imageNELAVL1;FUS;HNRNPK;IGF2BP2;NOP58;PTBP1;RBM47;SND1;U2AF2;UPF1NAT_cells_CD4_memory_restingGSVA_HALLMARK_P53_PATHWAY
chr1:225786926-225788665:+ESCAEERENSG00000119630,PGF0.27692.9065e-029.9654e-100.4607imageNELAVL1;FUS;HNRNPC;HNRNPK;MSI1;NOP56;RBFOX2;SND1;U2AF2PGFT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr1:225786926-225788665:+ESCAEERENSG00000072682,P4HA20.27213.4241e-029.0173e-110.4853imageNELAVL1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;MSI1;NOP56;NOP58;PTBP1;RBFOX2;RBM47;SND1;U2AF2;UPF1;DDX54;ELAVL3NAMacrophages_M0GSVA_HALLMARK_HYPOXIA
chr1:225786926-225788665:+ESCAEERENSG00000114450,GNB40.26274.2446e-021.9892e-080.4270imageNELAVL1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;MSI1;NOP56;NOP58;PTBP1;RBFOX2;RBM47;SND1;U2AF2;UPF1;DDX54;ELAVL3;LIN28ANAMacrophages_M1GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr1:225786926-225788665:+ESCAEERENSG00000235897,TM4SF19-AS10.25684.5333e-027.0176e-080.4116imageNELAVL1;FUS;HNRNPC;IGF2BP2;NOP56;NOP58;PTBP1;RBFOX2;U2AF2;UPF1NAT_cells_CD4_memory_restingGSVA_HALLMARK_BILE_ACID_METABOLISM
chr1:225786926-225788665:+PCPGEERENSG00000162139,NEU30.47221.9256e-062.9416e-090.4554imageNELAVL1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;NOP56;NOP58;PTBP1;RBFOX2;RBM47;SND1;U2AF2;UPF1;DDX54;ELAVL3;LIN28ANAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr1:225786926-225788665:+PCPGEERENSG00000172292,CERS60.46972.2360e-063.2845e-090.4542imageNELAVL1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;MSI1;NOP56;NOP58;PTBP1;RBFOX2;RBM47;SND1;U2AF2;UPF1;DDX54;ELAVL3;LIN28ANADendritic_cells_restingGSVA_HALLMARK_PROTEIN_SECRETION

More results



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4. Enriched editing regions and immune related splicing for SRP9


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr1:225786926-225788665:+
ESCAEERIRENSG00000118418.10chr679201244:79201726:79202093:79202155-0.24404.4499e-022.1423e-07-0.4134imageNELAVL1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;MSI1;NOP56;NOP58;PTBP1;RBFOX2;U2AF2;UPF1;DDX54;ELAVL3;LIN28ANAMacrophages_M2GSVA_HALLMARK_BILE_ACID_METABOLISM
chr1:225786926-225788665:+
KIRPEERIRENSG00000220205.4chr178159148:8160871:8161472:81615240.35037.9280e-055.1992e-100.4111imageNELAVL1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;NOP56;NOP58;PTBP1;RBFOX2;RBM47;SND1;U2AF2;UPF1;DDX54;ELAVL3;LIN28ANAMast_cells_restingGSVA_HALLMARK_PANCREAS_BETA_CELLS
chr1:225786926-225788665:+
KIRPEERIRENSG00000134285.6chr1248921960:48924648:48924773:489249670.29981.8269e-046.3961e-080.4002imageNELAVL1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;MSI1;NOP56;NOP58;PTBP1;RBFOX2;RBM47;SND1;U2AF2;UPF1;DDX54;ELAVL3;LIN28AFKBP11Mast_cells_restingGSVA_HALLMARK_PANCREAS_BETA_CELLS
chr1:225786926-225788665:+
KIRPEERIRENSG00000061656.5chr2035616879:35618130:35618449:356184750.35132.7831e-052.7985e-090.4094imageNELAVL1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;PTBP1;RBFOX2;SND1;U2AF2;DDX54NAT_cells_CD4_naiveGSVA_HALLMARK_PANCREAS_BETA_CELLS
chr1:225786926-225788665:+
KIRPEERIRENSG00000111325.12chr12122975463:122975867:122976653:1229767670.38215.9507e-065.5394e-120.4532imageNELAVL1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;NOP56;NOP58;PTBP1;RBFOX2;SND1;U2AF2;UPF1;DDX54;LIN28ANAMast_cells_restingGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr1:225786926-225788665:+
KIRPEERIRENSG00000176623.7chr886474819:86474914:86477293:864773170.33663.4644e-054.6572e-090.4041imageNELAVL1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;MSI1;NOP56;NOP58;PTBP1;RBFOX2;RBM47;SND1;U2AF2;UPF1;DDX54;ELAVL3;LIN28ANAMast_cells_restingGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
ENSG00000143742.11,SRP9
KIRPEAGIRENSG00000220205.4chr178159148:8160871:8161472:81615240.35048.1798e-055.1243e-100.4112imageNADAR;AIFM1;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL14;METTL3;MOV10;MSI2;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RC3H1;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZFP36;ZNF184NAMast_cells_restingGSVA_HALLMARK_PANCREAS_BETA_CELLS
ENSG00000143742.11,SRP9
KIRPEAGIRENSG00000176623.7chr886474819:86474914:86477293:864773170.33633.6703e-054.4906e-090.4045imageNADAR;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LIN28;LIN28A;LIN28B;LSM11;METTL14;MOV10;MSI1;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM27;RBM47;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YWHAG;ZC3H7B;ZNF184NAMast_cells_restingGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
ENSG00000143742.11,SRP9
KIRPEAGIRENSG00000061656.5chr2035616879:35618130:35618449:356184750.34743.8487e-056.6962e-090.4003imageNAUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX42;DDX54;DGCR8;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP2;IGF2BP3;ILF3;LARP4B;LIN28B;LSM11;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;U2AF1;U2AF2;XRN2;YWHAG;ZNF184NAT_cells_CD4_naiveGSVA_HALLMARK_PANCREAS_BETA_CELLS
ENSG00000143742.11,SRP9
KIRPEAGIRENSG00000134285.6chr1248921960:48924648:48924773:489249670.30041.8212e-045.8456e-080.4013imageNADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184FKBP11Mast_cells_restingGSVA_HALLMARK_PANCREAS_BETA_CELLS

More results



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5. Enriched editing regions and immune infiltration for SRP9


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000143742.11,SRP9ACCEAGMast_cells_resting4.6623e-03-0.4332image
chr1:225786926-225788665:+BLCAEERT_cells_CD4_memory_activated7.1370e-04-0.1969image
ENSG00000143742.11,SRP9BLCAEAGT_cells_CD4_memory_activated7.8048e-04-0.1952image
chr1:225786926-225788665:+BRCAEERT_cells_CD4_memory_resting5.6048e-060.1401image
ENSG00000143742.11,SRP9BRCAEAGT_cells_CD4_memory_resting8.8865e-060.1371image
chr1:225786926-225788665:+CESCEERT_cells_CD4_memory_resting1.4335e-020.1586image
ENSG00000143742.11,SRP9CESCEAGT_cells_CD4_memory_resting1.0783e-020.1647image
chr1:225786926-225788665:+COADEERMast_cells_activated1.7444e-030.2027image
ENSG00000143742.11,SRP9COADEAGMast_cells_activated1.9180e-030.2010image
ENSG00000143742.11,SRP9DLBCEAGMast_cells_resting1.2615e-020.4822image
chr1:225786926-225788665:+ESCAEERT_cells_gamma_delta2.9946e-050.3246image
ENSG00000143742.11,SRP9ESCAEAGT_cells_gamma_delta4.5769e-050.3174image
chr1:225786926-225788665:+KICHEERMacrophages_M19.4120e-040.4763image
ENSG00000143742.11,SRP9KICHEAGMacrophages_M17.2863e-040.4852image
chr1:225786926-225788665:+KIRCEERB_cells_naive2.0577e-020.1236image
ENSG00000143742.11,SRP9KIRCEAGB_cells_naive2.0587e-020.1236image
chr1:225786926-225788665:+KIRPEERT_cells_CD4_memory_resting7.3537e-040.2306image
ENSG00000143742.11,SRP9KIRPEAGT_cells_CD4_memory_resting7.6155e-040.2300image
ENSG00000143742.11,SRP9LAMLEAGMacrophages_M12.9243e-020.1928image
chr1:225786926-225788665:+LGGEERT_cells_CD4_memory_resting1.7244e-020.1047image
ENSG00000143742.11,SRP9LGGEAGT_cells_CD4_memory_resting1.6962e-020.1050image
chr1:225786926-225788665:+LIHCEERMonocytes1.8203e-020.1354image
ENSG00000143742.11,SRP9LIHCEAGMonocytes1.8189e-020.1354image
chr1:225786926-225788665:+LUADEERT_cells_CD4_memory_resting5.2271e-050.1819image
ENSG00000143742.11,SRP9LUADEAGT_cells_CD4_memory_resting5.2997e-050.1817image
chr1:225786926-225788665:+LUSCEERNeutrophils2.4793e-050.1924image
ENSG00000143742.11,SRP9LUSCEAGNeutrophils1.3262e-040.1746image
ENSG00000143742.11,SRP9OVEAGEosinophils4.5133e-020.1258image
chr1:225786926-225788665:+PAADEERT_cells_regulatory_(Tregs)4.2141e-020.1635image
ENSG00000143742.11,SRP9PAADEAGT_cells_regulatory_(Tregs)4.2068e-020.1635image
chr1:225786926-225788665:+PCPGEERMacrophages_M24.2739e-03-0.2290image
ENSG00000143742.11,SRP9PCPGEAGMacrophages_M24.2739e-03-0.2290image
chr1:225786926-225788665:+PRADEERT_cells_CD4_memory_resting1.5094e-020.1308image
ENSG00000143742.11,SRP9PRADEAGT_cells_CD4_memory_resting1.5094e-020.1308image
ENSG00000143742.11,SRP9READEAGMacrophages_M03.7668e-02-0.2328image
chr1:225786926-225788665:+SARCEERT_cells_CD4_memory_resting3.5709e-020.1589image
ENSG00000143742.11,SRP9SARCEAGT_cells_CD4_memory_resting3.5705e-020.1589image
chr1:225786926-225788665:+SKCMEERT_cells_CD4_memory_resting2.1353e-030.1543image
ENSG00000143742.11,SRP9SKCMEAGT_cells_CD4_memory_resting2.0821e-030.1546image
chr1:225784576-225785857:+STADEERT_cells_gamma_delta1.3964e-020.3327image
chr1:225786926-225788665:+STADEERDendritic_cells_resting7.5959e-030.1429image
ENSG00000143742.11,SRP9STADEAGDendritic_cells_resting1.9922e-020.1248image
ENSG00000143742.11,SRP9TGCTEAGT_cells_CD4_memory_activated1.6348e-020.2216image
chr1:225786926-225788665:+THCAEERMacrophages_M02.4454e-03-0.1564image
ENSG00000143742.11,SRP9THCAEAGMacrophages_M02.6566e-03-0.1548image
chr1:225786926-225788665:+UCECEEREosinophils9.9121e-030.2472image
ENSG00000143742.11,SRP9UCECEAGEosinophils9.9121e-030.2472image


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6. Enriched editing regions and immune gene sets for SRP9


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000143742.11,SRP9ACCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.5985e-02-0.3741image
chr1:225786926-225788665:+BLCAGSVA_HALLMARK_UV_RESPONSE_UPEER2.4912e-05-0.2440image
ENSG00000143742.11,SRP9BLCAGSVA_HALLMARK_UV_RESPONSE_UPEAG2.2921e-05-0.2447image
chr1:225786926-225788665:+BRCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER9.1997e-06-0.1369image
ENSG00000143742.11,SRP9BRCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.1954e-05-0.1351image
chr1:225786926-225788665:+CESCGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER1.0569e-02-0.1654image
ENSG00000143742.11,SRP9CESCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG9.5913e-03-0.1672image
chr1:225786926-225788665:+CHOLGSVA_HALLMARK_P53_PATHWAYEER3.6172e-04-0.5998image
ENSG00000143742.11,SRP9CHOLGSVA_HALLMARK_P53_PATHWAYEAG3.6612e-04-0.5994image
ENSG00000143742.11,SRP9COADGSVA_HALLMARK_DNA_REPAIREAG2.4219e-02-0.1467image
chr1:225786926-225788665:+COADGSVA_HALLMARK_DNA_REPAIREER2.2673e-02-0.1483image
chr1:225786926-225788665:+ESCAGSVA_HALLMARK_HYPOXIAEER1.7096e-020.1889image
ENSG00000143742.11,SRP9ESCAGSVA_HALLMARK_HYPOXIAEAG2.5468e-020.1772image
ENSG00000143742.11,SRP9GBMGSVA_HALLMARK_IL2_STAT5_SIGNALINGEAG3.8518e-030.2232image
chr1:225786926-225788665:+GBMGSVA_HALLMARK_IL2_STAT5_SIGNALINGEER3.9313e-030.2227image
ENSG00000143742.11,SRP9HNSCGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.1662e-030.1653image
chr1:225786926-225788665:+HNSCGSVA_HALLMARK_MITOTIC_SPINDLEEER2.1074e-030.1657image
ENSG00000143742.11,SRP9KICHGSVA_HALLMARK_MYC_TARGETS_V1EAG3.0369e-020.3232image
chr1:225786926-225788665:+KICHGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.8995e-02-0.3257image
ENSG00000143742.11,SRP9KIRCGSVA_HALLMARK_DNA_REPAIREAG5.9183e-05-0.2127image
chr1:225786926-225788665:+KIRCGSVA_HALLMARK_DNA_REPAIREER5.8549e-05-0.2128image
ENSG00000143742.11,SRP9KIRPGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.1496e-08-0.3737image
chr1:225786926-225788665:+KIRPGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.6952e-08-0.3762image
ENSG00000143742.11,SRP9LAMLGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG2.6423e-02-0.1962image
ENSG00000143742.11,SRP9LGGGSVA_HALLMARK_MITOTIC_SPINDLEEAG8.0222e-070.2150image
chr1:225786926-225788665:+LGGGSVA_HALLMARK_MITOTIC_SPINDLEEER8.1580e-070.2149image
ENSG00000143742.11,SRP9LIHCGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.2589e-070.2879image
chr1:225786926-225788665:+LIHCGSVA_HALLMARK_MITOTIC_SPINDLEEER3.2470e-070.2880image
chr1:225786926-225788665:+LUADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER4.0630e-06-0.2067image
ENSG00000143742.11,SRP9LUADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG4.0759e-06-0.2066image
ENSG00000143742.11,SRP9LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG9.7350e-03-0.1186image
chr1:225786926-225788665:+LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.7280e-02-0.1093image
ENSG00000143742.11,SRP9MESOGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG3.3343e-020.2823image
ENSG00000143742.11,SRP9OVGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.6254e-02-0.1507image
chr1:225786926-225788665:+OVGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER3.4275e-02-0.1329image
chr1:225786926-225788665:+PAADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER4.5398e-030.2268image
ENSG00000143742.11,SRP9PAADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG4.5491e-030.2268image
chr1:225786926-225788665:+PCPGGSVA_HALLMARK_MITOTIC_SPINDLEEER1.2663e-030.2575image
ENSG00000143742.11,SRP9PCPGGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.2663e-030.2575image
ENSG00000143742.11,SRP9PRADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.5719e-04-0.2021image
chr1:225786926-225788665:+PRADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.5719e-04-0.2021image
ENSG00000143742.11,SRP9READGSVA_HALLMARK_KRAS_SIGNALING_DNEAG3.2259e-02-0.2397image
ENSG00000143742.11,SRP9SARCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG1.3590e-02-0.1863image
chr1:225786926-225788665:+SARCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER1.3609e-02-0.1862image
ENSG00000143742.11,SRP9SKCMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.8179e-06-0.2334image
chr1:225786926-225788665:+SKCMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER3.0839e-06-0.2325image
ENSG00000143742.11,SRP9TGCTGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.7815e-040.3179image
chr1:225786926-225788665:+THCAGSVA_HALLMARK_MYC_TARGETS_V2EER4.1521e-06-0.2358image
ENSG00000143742.11,SRP9THCAGSVA_HALLMARK_MYC_TARGETS_V2EAG4.3374e-06-0.2347image
chr1:225786926-225788665:+THYMGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.8312e-030.3541image
ENSG00000143742.11,SRP9THYMGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.8312e-030.3541image
ENSG00000143742.11,SRP9UCECGSVA_HALLMARK_UV_RESPONSE_UPEAG7.7457e-04-0.3187image
chr1:225786926-225788665:+UCECGSVA_HALLMARK_UV_RESPONSE_UPEER7.7457e-04-0.3187image
chr1:225786926-225788665:+UCSGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER4.4439e-020.3577image
ENSG00000143742.11,SRP9UCSGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG4.4439e-020.3577image
ENSG00000143742.11,SRP9UVMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.5667e-02-0.5200image


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7. Enriched editing regions and drugs for SRP9


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000143742.11,SRP9ACCBI.D1870EAG4.1349e-02-0.3201image
chr1:225786926-225788665:+BLCACCT007093EER1.8553e-06-0.2749image
ENSG00000143742.11,SRP9BLCACCT007093EAG1.5572e-06-0.2763image
chr1:225786926-225788665:+BRCAAZD6482EER7.6649e-07-0.1526image
ENSG00000143742.11,SRP9BRCAAZD6482EAG8.7720e-07-0.1518image
chr1:225786926-225788665:+CESCBMS.536924EER4.9865e-040.2240image
ENSG00000143742.11,SRP9CESCAMG.706EAG2.4201e-040.2358image
chr1:225786926-225788665:+CHOLElesclomolEER1.3715e-02-0.4380image
ENSG00000143742.11,SRP9CHOLElesclomolEAG1.3812e-02-0.4376image
ENSG00000143742.11,SRP9COADBryostatin.1EAG3.1962e-030.1911image
chr1:225786926-225788665:+COADBryostatin.1EER3.1283e-030.1916image
ENSG00000143742.11,SRP9ESCAKU.55933EAG2.0310e-04-0.2914image
chr1:225786926-225788665:+ESCAKU.55933EER8.1086e-05-0.3083image
ENSG00000143742.11,SRP9GBMAZD6244EAG1.4161e-05-0.3300image
chr1:225786926-225788665:+GBMAZD6244EER1.4049e-05-0.3301image
ENSG00000143742.11,SRP9HNSCBleomycinEAG4.4039e-030.1536image
chr1:225786926-225788665:+HNSCBleomycinEER4.4437e-030.1535image
ENSG00000143742.11,SRP9KICHBAY.61.3606EAG2.0636e-03-0.4473image
chr1:225786926-225788665:+KICHBAY.61.3606EER2.5834e-03-0.4386image
ENSG00000143742.11,SRP9KIRCBMS.509744EAG3.9359e-110.3431image
chr1:225786926-225788665:+KIRCBMS.509744EER3.8986e-110.3432image
ENSG00000143742.11,SRP9KIRPDoxorubicinEAG3.4821e-06-0.3132image
chr1:225786926-225788665:+KIRPDoxorubicinEER3.7345e-06-0.3123image
ENSG00000143742.11,SRP9LAMLBX.795EAG2.4381e-02-0.1989image
chr1:225786926-225788665:+LGGEmbelinEER1.0363e-04-0.1699image
ENSG00000143742.11,SRP9LGGEmbelinEAG9.9093e-05-0.1704image
chr1:225786926-225788665:+LIHCDasatinibEER1.3935e-050.2569image
ENSG00000143742.11,SRP9LIHCDasatinibEAG1.3923e-050.2569image
chr1:225786926-225788665:+LUADBMS.509744EER5.5074e-090.2598image
ENSG00000143742.11,SRP9LUADBMS.509744EAG5.4551e-090.2599image
ENSG00000143742.11,SRP9LUSCBIBW2992EAG6.3979e-03-0.1251image
chr1:225786926-225788665:+LUSCBIBW2992EER5.4733e-03-0.1274image
ENSG00000143742.11,SRP9MESOABT.263EAG5.2315e-04-0.4450image
ENSG00000143742.11,SRP9OVBexaroteneEAG5.8164e-04-0.2144image
chr1:225786926-225788665:+OVBexaroteneEER1.2836e-03-0.2009image
ENSG00000143742.11,SRP9PAADBAY.61.3606EAG3.7175e-03-0.2340image
chr1:225786926-225788665:+PAADBAY.61.3606EER3.7138e-03-0.2340image
chr1:225786926-225788665:+PCPGCEP.701EER5.1840e-060.3579image
ENSG00000143742.11,SRP9PCPGCEP.701EAG5.1840e-060.3579image
ENSG00000143742.11,SRP9PRADBAY.61.3606EAG1.4610e-05-0.2310image
chr1:225786926-225788665:+PRADBAY.61.3606EER1.4610e-05-0.2310image
ENSG00000143742.11,SRP9READAKT.inhibitor.VIIIEAG1.9009e-02-0.2618image
ENSG00000143742.11,SRP9SARCCEP.701EAG3.5809e-040.2668image
chr1:225786926-225788665:+SARCCEP.701EER3.5940e-040.2667image
ENSG00000143742.11,SRP9SKCMAG.014699EAG1.3443e-07-0.2618image
chr1:225786926-225788665:+SKCMAG.014699EER1.4867e-07-0.2609image
chr1:225786926-225788665:+STADABT.263EER5.5842e-03-0.1487image
ENSG00000143742.11,SRP9STADABT.263EAG6.3843e-03-0.1464image
chr1:225784576-225785857:+STADIPA.3EER1.8632e-02-0.3192image
ENSG00000143742.11,SRP9TGCTBMS.509744EAG8.6599e-040.3039image
ENSG00000143742.11,SRP9THCAAZD6482EAG6.0825e-07-0.2542image
chr1:225786926-225788665:+THCAAZD6482EER9.5368e-07-0.2505image
ENSG00000143742.11,SRP9THYMImatinibEAG5.7374e-03-0.3161image
chr1:225786926-225788665:+THYMImatinibEER5.7374e-03-0.3161image
ENSG00000143742.11,SRP9UCECBMS.509744EAG5.3062e-050.3787image
chr1:225786926-225788665:+UCECBMS.509744EER5.3062e-050.3787image
chr1:225786926-225788665:+UCSGDC.0449EER8.2904e-030.4586image
ENSG00000143742.11,SRP9UCSGDC.0449EAG8.2904e-030.4586image
ENSG00000143742.11,SRP9UVMCCT018159EAG2.8196e-03-0.6182image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType