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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: SOD2 (ImmuneEditome ID:6648)

1. Gene summary of enriched editing regions for SOD2

check button Gene summary
Gene informationGene symbol

SOD2

Gene ID

6648

GeneSynonymsGC1|GClnc1|IPO-B|IPOB|MNSOD|MVCD6|Mn-SOD
GeneCytomap

6q25.3

GeneTypeprotein-coding
GeneDescriptionsuperoxide dismutase [Mn], mitochondrial|Mn superoxide dismutase|epididymis secretory sperm binding protein|gastric cancer-associated lncRNA 1|indophenoloxidase B|manganese-containing superoxide dismutase|mangano-superoxide dismutase|superoxide dismutase 2, mitochondrial
GeneModificationdate20230521
UniprotIDP04179;G5E9P6;F5GXZ9;F5H4R2;F5H3C5;G8JLJ2;F5GYZ5
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr6:159669296-159670256:-ENST00000538183.5ENSG00000112096.15SOD2UTR3L1M2,AluJrchr6:159669296-159670256:-.alignment
chr6:159677710-159678341:-ENST00000538183.5ENSG00000112096.15SOD2UTR3MER21B,AluSz,AluJochr6:159677710-159678341:-.alignment
chr6:159679776-159680819:-ENST00000538183.5ENSG00000112096.15SOD2UTR3AluSz,(CA)n,A-richchr6:159679776-159680819:-.alignment
chr6:159679776-159680819:-ENST00000546260.4ENSG00000112096.15SOD2UTR3AluSz,(CA)n,A-richchr6:159679776-159680819:-.alignment
chr6:159685291-159687434:-ENST00000535459.4ENSG00000112096.15SOD2ncRNA_intronicAluSz,L1PA16,AluSp,AluSx1,Tigger19bchr6:159685291-159687434:-.alignment
chr6:159685291-159687434:-ENST00000540491.1ENSG00000112096.15SOD2ncRNA_intronicAluSz,L1PA16,AluSp,AluSx1,Tigger19bchr6:159685291-159687434:-.alignment
chr6:159685291-159687434:-ENST00000541573.4ENSG00000112096.15SOD2ncRNA_intronicAluSz,L1PA16,AluSp,AluSx1,Tigger19bchr6:159685291-159687434:-.alignment
chr6:159696736-159696970:-ENST00000401980.3ENSG00000112096.15SOD2intronicMLT1J,AluJrchr6:159696736-159696970:-.alignment
chr6:159696736-159696970:-ENST00000535561.4ENSG00000112096.15SOD2intronicMLT1J,AluJrchr6:159696736-159696970:-.alignment
chr6:159696736-159696970:-ENST00000537657.4ENSG00000112096.15SOD2intronicMLT1J,AluJrchr6:159696736-159696970:-.alignment
chr6:159696736-159696970:-ENST00000545162.4ENSG00000112096.15SOD2intronicMLT1J,AluJrchr6:159696736-159696970:-.alignment
chr6:159696736-159696970:-ENST00000546087.4ENSG00000112096.15SOD2intronicMLT1J,AluJrchr6:159696736-159696970:-.alignment
chr6:159718084-159718320:-ENST00000401980.3ENSG00000112096.15SOD2intronicL1MA5,AluJrchr6:159718084-159718320:-.alignment
chr6:159718084-159718320:-ENST00000535561.4ENSG00000112096.15SOD2intronicL1MA5,AluJrchr6:159718084-159718320:-.alignment
chr6:159718084-159718320:-ENST00000537657.4ENSG00000112096.15SOD2intronicL1MA5,AluJrchr6:159718084-159718320:-.alignment
chr6:159718084-159718320:-ENST00000545162.4ENSG00000112096.15SOD2intronicL1MA5,AluJrchr6:159718084-159718320:-.alignment
chr6:159718084-159718320:-ENST00000546087.4ENSG00000112096.15SOD2intronicL1MA5,AluJrchr6:159718084-159718320:-.alignment
chr6:159723788-159725347:-ENST00000401980.3ENSG00000112096.15SOD2intronicAluSx,GA-rich,AluJo,AluJb,AluJr4,L1MC5a,MER8chr6:159723788-159725347:-.alignment
chr6:159723788-159725347:-ENST00000535561.4ENSG00000112096.15SOD2intronicAluSx,GA-rich,AluJo,AluJb,AluJr4,L1MC5a,MER8chr6:159723788-159725347:-.alignment
chr6:159723788-159725347:-ENST00000537657.4ENSG00000112096.15SOD2intronicAluSx,GA-rich,AluJo,AluJb,AluJr4,L1MC5a,MER8chr6:159723788-159725347:-.alignment
chr6:159723788-159725347:-ENST00000545162.4ENSG00000112096.15SOD2intronicAluSx,GA-rich,AluJo,AluJb,AluJr4,L1MC5a,MER8chr6:159723788-159725347:-.alignment
chr6:159723788-159725347:-ENST00000546087.4ENSG00000112096.15SOD2intronicAluSx,GA-rich,AluJo,AluJb,AluJr4,L1MC5a,MER8chr6:159723788-159725347:-.alignment


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2. Tumor-specific enriched editing regions for SOD2


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
ENSG00000112096.15,SOD2BRCAEAG3.1893e-06image
ENSG00000112096.15,SOD2KIRCEAG2.1287e-14image
ENSG00000112096.15,SOD2KIRPEAG2.0346e-08image
chr6:159679776-159680819:-LIHCEER1.8174e-03image
ENSG00000112096.15,SOD2LIHCEAG1.7094e-04image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr6:159685291-159687434:-LUADPathEER4.3636e-022.7816e-02-0.4796image
ENSG00000112096.15,SOD2TGCTCliEAG3.3268e-021.1814e-02-0.3258image
chr6:159679776-159680819:-TGCTCliEER8.3273e-036.6257e-03-0.3526image
ENSG00000112096.15,SOD2UCSCliEAG4.0284e-021.6544e-02-0.3916image
chr6:159679776-159680819:-UCSCliEER4.6530e-022.7062e-02-0.3634image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr6:159679776-159680819:-HNSCEER4.8243e-034.1341e-039.7068e+03image
chr6:159669296-159670256:-KIRCEER3.1263e-026.5170e-035.9569e-03image

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3. Enriched editing regions and immune related genes for SOD2


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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4. Enriched editing regions and immune related splicing for SOD2


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000112096.15,SOD2
ESCAEAGESENSG00000147852.11chr92650369:2650516:2651414:2651498:2651873:26519540.33138.8258e-036.2908e-080.4452imageNADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CSTF2T;DGCR8;DICER1;DKC1;EIF4A3;ELAVL1;EWSR1;FBL;FKBP4;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS2;LIN28;LIN28A;LIN28B;MOV10;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;RANGAP1;RBFOX2;RBM10;RBM47;RBM5;SF3A3;SF3B4;SND1;SRSF1;SRSF3;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;UPF1;VIM;YTHDC1;YTHDF1;ZC3H7B;ZNF184VLDLRMast_cells_restingGSVA_HALLMARK_ANGIOGENESIS
ENSG00000112096.15,SOD2
STADEAGIRENSG00000011422.7chr1943656478:43656640:43660973:436613240.26984.6974e-062.7217e-110.4029imageNADAR;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DGCR8;DHX9;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;ILF3;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MOV10;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RBFOX2;RBM10;RBM47;SAFB2;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDF1;YWHAG;ZFP36;ZNF184PLAURMacrophages_M2GSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALING

More results



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5. Enriched editing regions and immune infiltration for SOD2


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr6:159679776-159680819:-BLCAEERT_cells_follicular_helper3.1353e-030.1992image
ENSG00000112096.15,SOD2BLCAEAGB_cells_naive8.0610e-030.1703image
chr6:159669296-159670256:-BRCAEERNK_cells_activated1.3544e-030.4178image
chr6:159679776-159680819:-BRCAEERB_cells_naive2.4624e-08-0.2074image
ENSG00000112096.15,SOD2BRCAEAGDendritic_cells_resting6.3300e-030.1009image
chr6:159679776-159680819:-CESCEERB_cells_naive3.8894e-03-0.1975image
ENSG00000112096.15,SOD2CESCEAGT_cells_CD4_memory_resting1.8878e-020.1568image
chr6:159679776-159680819:-CHOLEERMast_cells_activated4.0666e-020.4396image
chr6:159679776-159680819:-COADEERDendritic_cells_activated1.1382e-030.3358image
ENSG00000112096.15,SOD2COADEAGEosinophils3.1589e-020.2184image
chr6:159669296-159670256:-ESCAEERNK_cells_resting1.4399e-020.3511image
chr6:159679776-159680819:-ESCAEERT_cells_regulatory_(Tregs)4.9372e-06-0.3803image
chr6:159685291-159687434:-ESCAEERNK_cells_activated1.9111e-02-0.2329image
chr6:159723788-159725347:-ESCAEERNK_cells_resting1.2909e-02-0.4347image
ENSG00000112096.15,SOD2ESCAEAGMonocytes2.7969e-020.1738image
chr6:159679776-159680819:-GBMEERMacrophages_M14.5652e-030.2511image
ENSG00000112096.15,SOD2GBMEAGDendritic_cells_activated7.8792e-040.2866image
chr6:159679776-159680819:-HNSCEEREosinophils4.4483e-030.1494image
ENSG00000112096.15,SOD2HNSCEAGT_cells_CD82.7362e-020.1146image
chr6:159669296-159670256:-KIRCEERDendritic_cells_resting2.6215e-020.1736image
chr6:159677710-159678341:-KIRCEERMacrophages_M22.0632e-02-0.4602image
chr6:159679776-159680819:-KIRCEERPlasma_cells1.6899e-040.2636image
chr6:159685291-159687434:-KIRCEERT_cells_follicular_helper4.4317e-02-0.2162image
ENSG00000112096.15,SOD2KIRCEAGMacrophages_M23.0011e-040.2046image
chr6:159669296-159670256:-KIRPEERMacrophages_M02.4093e-020.3562image
chr6:159679776-159680819:-KIRPEERMacrophages_M18.1584e-030.3116image
ENSG00000112096.15,SOD2LGGEAGT_cells_CD4_memory_resting4.6387e-03-0.2547image
chr6:159669296-159670256:-LIHCEERT_cells_CD4_memory_resting1.2968e-02-0.2717image
chr6:159679776-159680819:-LIHCEERNK_cells_activated1.1006e-030.1752image
ENSG00000112096.15,SOD2LIHCEAGT_cells_regulatory_(Tregs)1.1734e-030.1733image
chr6:159679776-159680819:-LUADEERT_cells_gamma_delta1.7751e-020.1604image
ENSG00000112096.15,SOD2LUADEAGDendritic_cells_resting7.2802e-030.1718image
chr6:159679776-159680819:-LUSCEERT_cells_follicular_helper6.8552e-040.1757image
ENSG00000112096.15,SOD2LUSCEAGB_cells_memory8.9585e-050.2004image
chr6:159679776-159680819:-MESOEERB_cells_naive1.8358e-02-0.3088image
ENSG00000112096.15,SOD2MESOEAGMast_cells_activated3.1858e-040.4327image
chr6:159679776-159680819:-OVEERT_cells_follicular_helper8.0694e-030.1572image
chr6:159685291-159687434:-OVEERB_cells_naive1.0474e-020.4396image
ENSG00000112096.15,SOD2OVEAGT_cells_follicular_helper1.4230e-020.1448image
chr6:159679776-159680819:-PCPGEERNK_cells_resting2.7693e-020.2334image
ENSG00000112096.15,SOD2PCPGEAGNK_cells_resting2.9799e-020.2292image
ENSG00000112096.15,SOD2PRADEAGEosinophils8.7762e-030.2184image
chr6:159679776-159680819:-READEERT_cells_CD4_memory_resting1.3695e-020.5172image
ENSG00000112096.15,SOD2READEAGT_cells_CD4_memory_resting2.6134e-030.5974image
chr6:159669296-159670256:-SARCEERMast_cells_resting3.7214e-02-0.4106image
chr6:159679776-159680819:-SARCEERMacrophages_M01.9093e-020.2146image
ENSG00000112096.15,SOD2SARCEAGDendritic_cells_resting3.5174e-020.1782image
ENSG00000112096.15,SOD2SKCMEAGDendritic_cells_activated1.3506e-140.5380image
chr6:159669296-159670256:-STADEERT_cells_gamma_delta1.2512e-030.4170image
chr6:159679776-159680819:-STADEERNK_cells_activated1.3954e-020.1430image
chr6:159723788-159725347:-STADEERMacrophages_M02.8898e-020.3865image
ENSG00000112096.15,SOD2STADEAGB_cells_naive7.6562e-050.2134image
chr6:159679776-159680819:-TGCTEERB_cells_naive3.7536e-110.5760image
ENSG00000112096.15,SOD2TGCTEAGB_cells_naive4.8626e-100.5458image
ENSG00000112096.15,SOD2THCAEAGT_cells_regulatory_(Tregs)6.6611e-040.2893image
chr6:159679776-159680819:-THYMEERT_cells_CD4_naive2.3270e-02-0.3627image
ENSG00000112096.15,SOD2THYMEAGPlasma_cells1.8318e-020.3583image
chr6:159679776-159680819:-UCECEERDendritic_cells_activated2.2137e-040.3031image
ENSG00000112096.15,SOD2UCECEAGMast_cells_activated1.1480e-070.4178image
ENSG00000112096.15,SOD2UCSEAGMacrophages_M23.7424e-02-0.3434image


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6. Enriched editing regions and immune gene sets for SOD2


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr6:159679776-159680819:-LIHCEER3.1340e-02image7.9921e-04-0.1800image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr6:159679776-159680819:-ACCGSVA_HALLMARK_ANGIOGENESISEER2.4459e-02-0.3351image
ENSG00000112096.15,SOD2ACCGSVA_HALLMARK_ANGIOGENESISEAG2.0620e-02-0.3404image
ENSG00000112096.15,SOD2BLCAGSVA_HALLMARK_MYC_TARGETS_V2EAG1.1165e-04-0.2463image
chr6:159679776-159680819:-BLCAGSVA_HALLMARK_MYOGENESISEER7.1878e-04-0.2274image
chr6:159669296-159670256:-BRCAGSVA_HALLMARK_PROTEIN_SECRETIONEER3.3630e-030.3853image
ENSG00000112096.15,SOD2BRCAGSVA_HALLMARK_G2M_CHECKPOINTEAG8.2435e-03-0.0977image
chr6:159679776-159680819:-BRCAGSVA_HALLMARK_UV_RESPONSE_DNEER2.4624e-10-0.2346image
chr6:159679776-159680819:-CESCGSVA_HALLMARK_UV_RESPONSE_DNEER2.7477e-03-0.2047image
ENSG00000112096.15,SOD2CESCGSVA_HALLMARK_MTORC1_SIGNALINGEAG1.3714e-02-0.1645image
ENSG00000112096.15,SOD2CHOLGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG4.6104e-020.4024image
chr6:159679776-159680819:-COADGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.2635e-02-0.2605image
ENSG00000112096.15,SOD2COADGSVA_HALLMARK_MYC_TARGETS_V2EAG2.6233e-04-0.3626image
chr6:159669296-159670256:-ESCAGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER9.4085e-03-0.3711image
chr6:159723788-159725347:-ESCAGSVA_HALLMARK_NOTCH_SIGNALINGEER8.4415e-03-0.4577image
chr6:159679776-159680819:-ESCAGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.5399e-03-0.2690image
ENSG00000112096.15,SOD2ESCAGSVA_HALLMARK_SPERMATOGENESISEAG2.7174e-02-0.1747image
chr6:159685291-159687434:-ESCAGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER6.4552e-03-0.2693image
chr6:159669296-159670256:-GBMGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER3.7637e-02-0.4266image
ENSG00000112096.15,SOD2GBMGSVA_HALLMARK_IL2_STAT5_SIGNALINGEAG3.4752e-030.2507image
chr6:159679776-159680819:-GBMGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER7.9099e-03-0.2356image
chr6:159679776-159680819:-HNSCGSVA_HALLMARK_MYC_TARGETS_V1EER1.0860e-050.2292image
ENSG00000112096.15,SOD2HNSCGSVA_HALLMARK_DNA_REPAIREAG3.2975e-030.1522image
chr6:159679776-159680819:-KIRCGSVA_HALLMARK_TGF_BETA_SIGNALINGEER4.7654e-04-0.2454image
chr6:159669296-159670256:-KIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.2548e-030.2285image
chr6:159685291-159687434:-KIRCGSVA_HALLMARK_SPERMATOGENESISEER4.7524e-020.2131image
ENSG00000112096.15,SOD2KIRPGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG1.4361e-040.3336image
chr6:159669296-159670256:-KIRPGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER2.6451e-03-0.4627image
chr6:159679776-159680819:-KIRPGSVA_HALLMARK_G2M_CHECKPOINTEER1.5515e-020.2863image
ENSG00000112096.15,SOD2LAMLGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG1.3124e-02-0.3485image
ENSG00000112096.15,SOD2LGGGSVA_HALLMARK_MTORC1_SIGNALINGEAG9.1401e-04-0.2965image
chr6:159679776-159680819:-LIHCGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER7.3453e-06-0.2391image
chr6:159669296-159670256:-LIHCGSVA_HALLMARK_APICAL_SURFACEEER2.7093e-03-0.3251image
ENSG00000112096.15,SOD2LIHCGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.4256e-03-0.1703image
ENSG00000112096.15,SOD2LUADGSVA_HALLMARK_SPERMATOGENESISEAG2.7945e-05-0.2653image
chr6:159679776-159680819:-LUADGSVA_HALLMARK_MYC_TARGETS_V1EER4.0391e-030.1940image
ENSG00000112096.15,SOD2LUSCGSVA_HALLMARK_UV_RESPONSE_DNEAG2.0522e-07-0.2637image
chr6:159679776-159680819:-LUSCGSVA_HALLMARK_MYOGENESISEER1.4528e-10-0.3253image
ENSG00000112096.15,SOD2MESOGSVA_HALLMARK_NOTCH_SIGNALINGEAG3.0606e-020.2684image
chr6:159679776-159680819:-MESOGSVA_HALLMARK_GLYCOLYSISEER8.4712e-030.3426image
chr6:159685291-159687434:-OVGSVA_HALLMARK_DNA_REPAIREER4.3877e-020.3530image
ENSG00000112096.15,SOD2OVGSVA_HALLMARK_UV_RESPONSE_DNEAG1.2435e-07-0.3064image
chr6:159679776-159680819:-OVGSVA_HALLMARK_UV_RESPONSE_DNEER4.8779e-07-0.2937image
ENSG00000112096.15,SOD2PAADGSVA_HALLMARK_KRAS_SIGNALING_UPEAG2.0134e-050.5738image
chr6:159679776-159680819:-PCPGGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER1.6433e-04-0.3891image
ENSG00000112096.15,SOD2PCPGGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG3.3777e-04-0.3695image
ENSG00000112096.15,SOD2PRADGSVA_HALLMARK_DNA_REPAIREAG4.8725e-04-0.2880image
ENSG00000112096.15,SOD2READGSVA_HALLMARK_APICAL_JUNCTIONEAG3.5382e-03-0.5825image
chr6:159679776-159680819:-READGSVA_HALLMARK_MYOGENESISEER9.6033e-03-0.5392image
ENSG00000112096.15,SOD2SARCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG4.8105e-05-0.3365image
chr6:159679776-159680819:-SARCGSVA_HALLMARK_UV_RESPONSE_DNEER4.0083e-03-0.2619image
chr6:159679776-159680819:-SKCMGSVA_HALLMARK_APOPTOSISEER2.9551e-04-0.2750image
ENSG00000112096.15,SOD2SKCMGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG4.9500e-02-0.1483image
chr6:159679776-159680819:-STADGSVA_HALLMARK_UV_RESPONSE_DNEER4.4361e-08-0.3120image
chr6:159685291-159687434:-STADGSVA_HALLMARK_DNA_REPAIREER7.2703e-030.2236image
chr6:159723788-159725347:-STADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.3021e-040.6252image
ENSG00000112096.15,SOD2STADGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.5106e-06-0.2528image
ENSG00000112096.15,SOD2TGCTGSVA_HALLMARK_COAGULATIONEAG8.0218e-10-0.5400image
chr6:159679776-159680819:-TGCTGSVA_HALLMARK_COAGULATIONEER1.6111e-10-0.5603image
ENSG00000112096.15,SOD2THCAGSVA_HALLMARK_HEME_METABOLISMEAG1.3741e-05-0.3646image
chr6:159679776-159680819:-THYMGSVA_HALLMARK_MITOTIC_SPINDLEEER7.0563e-04-0.5193image
ENSG00000112096.15,SOD2THYMGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.0057e-03-0.4841image
ENSG00000112096.15,SOD2UCECGSVA_HALLMARK_G2M_CHECKPOINTEAG1.1321e-02-0.2070image
chr6:159679776-159680819:-UCECGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER6.1632e-04-0.2820image
ENSG00000112096.15,SOD2UCSGSVA_HALLMARK_SPERMATOGENESISEAG4.7329e-020.3282image
chr6:159679776-159680819:-UCSGSVA_HALLMARK_SPERMATOGENESISEER8.5205e-030.4263image


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7. Enriched editing regions and drugs for SOD2


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000112096.15,SOD2BLCAAZD6482EAG1.7309e-04-0.2396image
chr6:159679776-159680819:-BLCAAxitinibEER2.4165e-060.3131image
chr6:159669296-159670256:-BRCAGefitinibEER2.1359e-020.3070image
ENSG00000112096.15,SOD2BRCACHIR.99021EAG2.8796e-02-0.0809image
chr6:159679776-159680819:-BRCAImatinibEER2.2710e-060.1764image
chr6:159669296-159670256:-CESCATRAEER4.0367e-02-0.3897image
chr6:159679776-159680819:-CESCGDC0941EER1.9292e-030.2118image
ENSG00000112096.15,SOD2CESCEmbelinEAG6.5934e-040.2259image
chr6:159679776-159680819:-CHOLCI.1040EER1.2627e-020.5224image
ENSG00000112096.15,SOD2CHOLCMKEAG4.3323e-020.4073image
chr6:159679776-159680819:-COADKIN001.135EER1.9877e-02-0.2438image
ENSG00000112096.15,SOD2COADImatinibEAG5.3516e-06-0.4436image
ENSG00000112096.15,SOD2ESCAAP.24534EAG7.6404e-04-0.2634image
chr6:159679776-159680819:-ESCAErlotinibEER1.8844e-06-0.3955image
chr6:159723788-159725347:-ESCAEHT.1864EER2.7723e-02-0.3891image
chr6:159685291-159687434:-ESCABX.795EER1.1762e-020.2498image
chr6:159669296-159670256:-GBMFTI.277EER2.8891e-030.5813image
chr6:159679776-159680819:-GBMBAY.61.3606EER4.7262e-030.2502image
ENSG00000112096.15,SOD2GBMEHT.1864EAG3.7910e-030.2485image
chr6:159679776-159680819:-HNSCCCT007093EER4.9122e-070.2610image
ENSG00000112096.15,SOD2HNSCBX.795EAG1.9962e-050.2195image
chr6:159677710-159678341:-KIRCAKT.inhibitor.VIIIEER2.1600e-030.5843image
chr6:159685291-159687434:-KIRCEpothilone.BEER1.5528e-02-0.2587image
ENSG00000112096.15,SOD2KIRCGSK269962AEAG1.4924e-020.1386image
chr6:159679776-159680819:-KIRCCCT007093EER2.1991e-050.2959image
chr6:159669296-159670256:-KIRCBI.D1870EER6.6052e-030.2113image
chr6:159669296-159670256:-KIRPAZD6482EER5.3349e-050.5940image
ENSG00000112096.15,SOD2KIRPAZD6482EAG1.1846e-03-0.2868image
chr6:159679776-159680819:-KIRPCGP.082996EER3.5331e-03-0.3418image
ENSG00000112096.15,SOD2LAMLKU.55933EAG2.2886e-020.3213image
ENSG00000112096.15,SOD2LGGJNK.9LEAG4.1444e-03-0.2578image
chr6:159679776-159680819:-LIHCBMS.708163EER2.2266e-050.2265image
ENSG00000112096.15,SOD2LIHCAICAREAG9.4792e-120.3546image
chr6:159669296-159670256:-LIHCMetforminEER1.2120e-03-0.3492image
ENSG00000112096.15,SOD2LUADGSK.650394EAG7.0270e-030.1725image
chr6:159679776-159680819:-LUADElesclomolEER5.5533e-06-0.3022image
chr6:159679776-159680819:-LUSCAP.24534EER3.5817e-070.2609image
ENSG00000112096.15,SOD2LUSCCMKEAG6.8935e-080.2734image
ENSG00000112096.15,SOD2MESOEmbelinEAG2.0157e-070.5924image
chr6:159679776-159680819:-MESOBI.D1870EER3.2136e-02-0.2818image
chr6:159685291-159687434:-OVKU.55933EER4.8939e-030.4781image
ENSG00000112096.15,SOD2OVImatinibEAG8.9251e-080.3097image
chr6:159679776-159680819:-OVImatinibEER6.2024e-080.3149image
ENSG00000112096.15,SOD2PAADAP.24534EAG9.5451e-04-0.4618image
chr6:159679776-159680819:-PCPGMethotrexateEER3.2402e-020.2270image
ENSG00000112096.15,SOD2PCPGMethotrexateEAG3.2410e-020.2257image
ENSG00000112096.15,SOD2PRADBX.795EAG7.4440e-04-0.2789image
chr6:159679776-159680819:-READAS601245EER1.0698e-030.6496image
ENSG00000112096.15,SOD2READDocetaxelEAG3.0943e-03-0.5892image
chr6:159669296-159670256:-SARCGefitinibEER3.0960e-02-0.4238image
ENSG00000112096.15,SOD2SARCCamptothecinEAG6.3251e-040.2853image
chr6:159679776-159680819:-SARCDMOGEER6.7899e-060.3994image
chr6:159679776-159680819:-SKCMGDC0941EER3.0936e-040.2742image
ENSG00000112096.15,SOD2SKCMGSK269962AEAG4.4156e-11-0.4717image
chr6:159679776-159680819:-STADGW.441756EER2.2330e-05-0.2442image
chr6:159685291-159687434:-STADGW843682XEER8.8830e-03-0.2181image
chr6:159669296-159670256:-STADJNJ.26854165EER1.7417e-020.3139image
chr6:159723788-159725347:-STADJNK.Inhibitor.VIIIEER2.5823e-040.6032image
ENSG00000112096.15,SOD2STADAG.014699EAG1.8729e-02-0.1280image
ENSG00000112096.15,SOD2TGCTBortezomibEAG7.6225e-140.6323image
chr6:159679776-159680819:-TGCTBortezomibEER3.0262e-160.6779image
ENSG00000112096.15,SOD2THCABMS.708163EAG5.9373e-050.3385image
chr6:159679776-159680819:-THYMDMOGEER1.6622e-040.5672image
ENSG00000112096.15,SOD2THYMAZD6244EAG7.2698e-07-0.6740image
chr6:159679776-159680819:-UCECA.770041EER1.3324e-03-0.2649image
ENSG00000112096.15,SOD2UCECAxitinibEAG1.8841e-040.3013image
ENSG00000112096.15,SOD2UCSBX.795EAG2.6725e-020.3641image
chr6:159679776-159680819:-UCSCisplatinEER3.3629e-02-0.3501image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType
chr6:159669296-159670256:-ENST00000538183.5P04179DB09096Benzoyl peroxideSmallMoleculeDrug
chr6:159677710-159678341:-ENST00000538183.5P04179DB09096Benzoyl peroxideSmallMoleculeDrug
chr6:159679776-159680819:-ENST00000538183.5P04179DB09096Benzoyl peroxideSmallMoleculeDrug
chr6:159696736-159696970:-ENST00000546087.4P04179DB09096Benzoyl peroxideSmallMoleculeDrug
chr6:159718084-159718320:-ENST00000546087.4P04179DB09096Benzoyl peroxideSmallMoleculeDrug
chr6:159723788-159725347:-ENST00000546087.4P04179DB09096Benzoyl peroxideSmallMoleculeDrug