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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: SLC2A11 (ImmuneEditome ID:66035)

1. Gene summary of enriched editing regions for SLC2A11

check button Gene summary
Gene informationGene symbol

SLC2A11

Gene ID

66035

GeneSynonymsGLUT10|GLUT11
GeneCytomap

22q11.23

GeneTypeprotein-coding
GeneDescriptionsolute carrier family 2, facilitated glucose transporter member 11|facilitative glucose transporter GLUT11|glucose transporter protein 10|glucose transporter protein 11|glucose transporter type 10|glucose transporter type 11|glucose transporter-like protein XI|solute carrier family 2 (facilitated glucose transporter), member 11
GeneModificationdate20230329
UniprotIDA0A087X018;F8WFA8;Q9BYW1;B5MCM7;F8WBG9;F8WCV3;F8WB79;F8WBK0;B5MCM1
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr22:23885112-23885658:+ENST00000461809.4ENSG00000133460.18SLC2A11ncRNA_exonicAluJr4,AluJbchr22:23885112-23885658:+.alignment
chr22:23885112-23885658:+ENST00000486907.1ENSG00000133460.18SLC2A11ncRNA_exonicAluJr4,AluJbchr22:23885112-23885658:+.alignment
chr22:23885112-23885658:+ENST00000489322.4ENSG00000133460.18SLC2A11ncRNA_exonicAluJr4,AluJbchr22:23885112-23885658:+.alignment


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2. Tumor-specific enriched editing regions for SLC2A11


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr22:23885112-23885658:+BRCAEER9.0564e-03image
ENSG00000133460.18,SLC2A11BRCAEAG3.8874e-05image
chr22:23885112-23885658:+KIRCEER2.2180e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
ENSG00000133460.18,SLC2A11ESCAEAG3.5282e-021.6101e-021.1230e+03image

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3. Enriched editing regions and immune related genes for SLC2A11


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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4. Enriched editing regions and immune related splicing for SLC2A11


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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5. Enriched editing regions and immune infiltration for SLC2A11


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr22:23885112-23885658:+BLCAEERT_cells_CD4_memory_resting1.9075e-02-0.4953image
ENSG00000133460.18,SLC2A11BLCAEAGT_cells_CD4_memory_resting1.5784e-02-0.4775image
chr22:23885112-23885658:+BRCAEERT_cells_regulatory_(Tregs)2.9544e-030.1876image
ENSG00000133460.18,SLC2A11BRCAEAGT_cells_CD4_naive4.3771e-080.3131image
ENSG00000133460.18,SLC2A11CESCEAGMacrophages_M04.6113e-020.4294image
chr22:23885112-23885658:+ESCAEERMacrophages_M21.6967e-020.4555image
ENSG00000133460.18,SLC2A11ESCAEAGNK_cells_resting5.6376e-030.4018image
ENSG00000133460.18,SLC2A11KICHEAGT_cells_follicular_helper2.8215e-02-0.3710image
chr22:23885112-23885658:+KIRCEERT_cells_CD4_memory_resting6.8217e-04-0.2529image
ENSG00000133460.18,SLC2A11KIRCEAGB_cells_memory4.1258e-070.3557image
chr22:23885112-23885658:+KIRPEERMacrophages_M03.7836e-020.2524image
ENSG00000133460.18,SLC2A11KIRPEAGMast_cells_resting1.3180e-020.2239image
ENSG00000133460.18,SLC2A11LUADEAGT_cells_CD4_memory_resting1.8170e-020.2669image
ENSG00000133460.18,SLC2A11LUSCEAGB_cells_naive2.6604e-020.2963image
chr22:23885112-23885658:+OVEERT_cells_follicular_helper2.3725e-02-0.2081image
ENSG00000133460.18,SLC2A11OVEAGNK_cells_activated2.0922e-030.2477image
ENSG00000133460.18,SLC2A11PAADEAGEosinophils7.5936e-030.4936image
chr22:23885112-23885658:+PCPGEERMacrophages_M04.3676e-020.1877image
ENSG00000133460.18,SLC2A11PCPGEAGMacrophages_M01.9269e-020.2108image
ENSG00000133460.18,SLC2A11PRADEAGT_cells_CD82.9181e-020.1992image
ENSG00000133460.18,SLC2A11STADEAGDendritic_cells_activated1.0603e-030.3002image
chr22:23885112-23885658:+THCAEERT_cells_CD4_memory_activated2.0948e-020.1760image
ENSG00000133460.18,SLC2A11UCECEAGT_cells_gamma_delta7.5930e-040.6289image


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6. Enriched editing regions and immune gene sets for SLC2A11


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000133460.18,SLC2A11BLCAGSVA_HALLMARK_UV_RESPONSE_UPEAG4.2947e-020.4079image
chr22:23885112-23885658:+BLCAGSVA_HALLMARK_UV_RESPONSE_UPEER1.6512e-020.5050image
chr22:23885112-23885658:+BRCAGSVA_HALLMARK_GLYCOLYSISEER1.5773e-020.1529image
ENSG00000133460.18,SLC2A11BRCAGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.6177e-04-0.2186image
ENSG00000133460.18,SLC2A11CESCGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.1273e-030.6191image
chr22:23885112-23885658:+ESCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER4.3453e-050.7029image
ENSG00000133460.18,SLC2A11ESCAGSVA_HALLMARK_MYOGENESISEAG1.8328e-02-0.3465image
ENSG00000133460.18,SLC2A11GBMGSVA_HALLMARK_MYC_TARGETS_V1EAG3.2573e-030.3156image
ENSG00000133460.18,SLC2A11KICHGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.5994e-020.4043image
ENSG00000133460.18,SLC2A11KIRCGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG3.9541e-07-0.3562image
chr22:23885112-23885658:+KIRCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER4.3713e-050.3021image
ENSG00000133460.18,SLC2A11KIRPGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG3.5054e-020.1910image
ENSG00000133460.18,SLC2A11LAMLGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.4360e-020.5142image
ENSG00000133460.18,SLC2A11LGGGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG7.3579e-050.2038image
ENSG00000133460.18,SLC2A11LUSCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG4.6402e-02-0.2673image
chr22:23885112-23885658:+OVGSVA_HALLMARK_MYC_TARGETS_V1EER2.0000e-020.2140image
ENSG00000133460.18,SLC2A11OVGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG1.0024e-03-0.2643image
ENSG00000133460.18,SLC2A11PCPGGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG1.7533e-02-0.2139image
chr22:23885112-23885658:+PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEER3.2472e-03-0.2711image
ENSG00000133460.18,SLC2A11PRADGSVA_HALLMARK_BILE_ACID_METABOLISMEAG5.8950e-05-0.3582image
chr22:23885112-23885658:+SARCGSVA_HALLMARK_PROTEIN_SECRETIONEER7.8429e-030.4144image
ENSG00000133460.18,SLC2A11SARCGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.2086e-020.3884image
ENSG00000133460.18,SLC2A11STADGSVA_HALLMARK_E2F_TARGETSEAG3.3998e-040.3270image
chr22:23885112-23885658:+STADGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER1.3974e-020.2627image
ENSG00000133460.18,SLC2A11THCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG2.9861e-05-0.2618image
ENSG00000133460.18,SLC2A11UCECGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.4762e-020.4817image


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7. Enriched editing regions and drugs for SLC2A11


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr22:23885112-23885658:+BLCABortezomibEER8.3501e-03-0.5475image
chr22:23885112-23885658:+BRCABMS.754807EER9.6510e-03-0.1637image
ENSG00000133460.18,SLC2A11BRCABMS.536924EAG9.0942e-040.1934image
ENSG00000133460.18,SLC2A11CESCA.443654EAG3.3278e-030.5974image
chr22:23885112-23885658:+ESCABortezomibEER7.5292e-04-0.6088image
ENSG00000133460.18,SLC2A11GBMGefitinibEAG5.1774e-040.3686image
ENSG00000133460.18,SLC2A11KICHAZD6482EAG2.2969e-03-0.4986image
ENSG00000133460.18,SLC2A11KIRCLenalidomideEAG1.4599e-04-0.2707image
chr22:23885112-23885658:+KIRCAZD.2281EER1.0964e-06-0.3567image
chr22:23885112-23885658:+KIRPCytarabineEER4.7301e-02-0.2415image
ENSG00000133460.18,SLC2A11KIRPCisplatinEAG5.9041e-040.3067image
ENSG00000133460.18,SLC2A11LGGLFM.A13EAG8.9419e-040.1713image
ENSG00000133460.18,SLC2A11LUSCGW.441756EAG1.2807e-020.3307image
chr22:23885112-23885658:+OVCisplatinEER4.3169e-02-0.1865image
ENSG00000133460.18,SLC2A11OVDMOGEAG2.7382e-030.2414image
ENSG00000133460.18,SLC2A11PAADBX.795EAG2.1243e-030.5560image
ENSG00000133460.18,SLC2A11PCPGCCT018159EAG1.5045e-020.2188image
chr22:23885112-23885658:+PCPGGDC.0449EER7.0705e-05-0.3604image
ENSG00000133460.18,SLC2A11PRADAZD6482EAG2.1854e-030.2771image
chr22:23885112-23885658:+SARCJNJ.26854165EER8.3030e-030.4117image
ENSG00000133460.18,SLC2A11SARCJNJ.26854165EAG3.3439e-030.4476image
ENSG00000133460.18,SLC2A11STADAS601245EAG2.3044e-040.3356image
chr22:23885112-23885658:+STADDocetaxelEER1.5273e-03-0.3348image
chr22:23885112-23885658:+THCAAZD6482EER4.4845e-040.2648image
ENSG00000133460.18,SLC2A11THCAGemcitabineEAG2.2724e-040.2321image
ENSG00000133460.18,SLC2A11UCECAxitinibEAG2.4080e-030.5793image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType