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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: SH3BP2 (ImmuneEditome ID:6452)

1. Gene summary of enriched editing regions for SH3BP2

check button Gene summary
Gene informationGene symbol

SH3BP2

Gene ID

6452

GeneSynonyms3BP-2|3BP2|CRBM|CRPM|RES4-23
GeneCytomap

4p16.3

GeneTypeprotein-coding
GeneDescriptionSH3 domain-binding protein 2|Abl-SH3 binding protein 2|TNFAIP3 interacting protein 2|epididymis secretory sperm binding protein
GeneModificationdate20230329
UniprotIDP78314;D6RAB4;D6RBL6;D6RER9;D6R995;D6RC64
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr4:2839245-2840254:+ENST00000356331.8ENSG00000087266.14SH3BP2UTR3L1ME3B,AluJb,AluJrchr4:2839245-2840254:+.alignment
chr4:2839245-2840254:+ENST00000442312.5ENSG00000087266.14SH3BP2UTR3L1ME3B,AluJb,AluJrchr4:2839245-2840254:+.alignment
chr4:2839245-2840254:+ENST00000503393.5ENSG00000087266.14SH3BP2UTR3L1ME3B,AluJb,AluJrchr4:2839245-2840254:+.alignment


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2. Tumor-specific enriched editing regions for SH3BP2


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr4:2839245-2840254:+BRCAEER1.5531e-19image
ENSG00000087266.14,SH3BP2BRCAEAG2.7289e-19image
chr4:2839245-2840254:+KIRCEER4.8678e-07image
ENSG00000087266.14,SH3BP2KIRCEAG1.0215e-06image
chr4:2839245-2840254:+UCECEER3.9020e-04image
ENSG00000087266.14,SH3BP2UCECEAG3.9738e-04image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000087266.14,SH3BP2KIRCPathEAG2.1391e-023.7068e-030.1264image
chr4:2839245-2840254:+KIRCPathEER1.6853e-023.0073e-030.1292image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr4:2839245-2840254:+LUSCEER1.7253e-022.7138e-026.5800e-02image
ENSG00000087266.14,SH3BP2LUSCEAG1.7253e-022.6249e-026.4745e-02image
chr4:2839245-2840254:+UVMEER2.1815e-029.0773e-033.1568e-11image
ENSG00000087266.14,SH3BP2UVMEAG2.1815e-028.7851e-033.0956e-11image

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3. Enriched editing regions and immune related genes for SH3BP2


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr4:2839245-2840254:+LGGEERENSG00000087266,SH3BP2-0.50341.5094e-251.9428e-34-0.5294imageNAIFM1;AUH;BCCIP;CELF2;DGCR8;EIF4A3;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHSRP;LIN28;LIN28B;MOV10;MSI2;NOP56;NOP58;NUMA1;PTBP1;RANGAP1;RBFOX2;RBM10;SRSF1;TAF15;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;VIMNAT_cells_follicular_helperGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALING
chr4:2839245-2840254:+CESCEERENSG00000087266,SH3BP2-0.45905.4621e-125.1772e-14-0.4270imageNAIFM1;AUH;BCCIP;CELF2;DGCR8;EIF4A3;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHSRP;LIN28;LIN28B;MOV10;MSI2;NOP56;NOP58;NUMA1;PTBP1;RANGAP1;RBFOX2;RBM10;SRSF1;TAF15;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;VIMNAGSVA_HALLMARK_MYC_TARGETS_V1
chr4:2839245-2840254:+COADEERENSG00000267523,CTD-2537I9.12-0.24904.0793e-037.6604e-140.4529imageNFUS;NOP56;TAF15;UPF1NADendritic_cells_activatedGSVA_HALLMARK_ADIPOGENESIS
chr4:2839245-2840254:+COADEERENSG00000220205,VAMP20.22071.4058e-021.3094e-130.4490imageNAIFM1;AUH;BCCIP;CELF2;DGCR8;EIF4A3;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHSRP;LIN28;LIN28B;MOV10;MSI2;NOP56;NOP58;NUMA1;PTBP1;RANGAP1;RBFOX2;RBM10;SRSF1;TAF15;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;VIMNADendritic_cells_activatedGSVA_HALLMARK_MYC_TARGETS_V2
chr4:2839245-2840254:+GBMEERENSG00000087266,SH3BP2-0.47708.7074e-071.6906e-09-0.4537imageNAIFM1;AUH;BCCIP;CELF2;DGCR8;EIF4A3;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHSRP;LIN28;LIN28B;MOV10;MSI2;NOP56;NOP58;NUMA1;PTBP1;RANGAP1;RBFOX2;RBM10;SRSF1;TAF15;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;VIMNANK_cells_restingGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr4:2839245-2840254:+GBMEERENSG00000242858,CTC-484M2.10.41663.7178e-053.1796e-080.4202imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MYC_TARGETS_V1
chr4:2839245-2840254:+GBMEERENSG00000224858,RPL29P110.41145.3400e-051.0701e-080.4330imageNNNANK_cells_activatedGSVA_HALLMARK_APICAL_JUNCTION
chr4:2839245-2840254:+GBMEERENSG00000215482,CALM2P30.40467.2049e-056.5415e-080.4113imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr4:2839245-2840254:+GBMEERENSG00000231120,BTF3P100.40578.4119e-051.3600e-070.4021imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MYC_TARGETS_V1
chr4:2839245-2840254:+GBMEERENSG00000177855,CACYBPP20.40171.0665e-041.2248e-080.4315imageNNNANK_cells_restingGSVA_HALLMARK_APICAL_JUNCTION
chr4:2839245-2840254:+LGGEERENSG00000087266,SH3BP2-0.50341.5094e-251.9428e-34-0.5294imageNAIFM1;AUH;BCCIP;CELF2;DGCR8;EIF4A3;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHSRP;LIN28;LIN28B;MOV10;MSI2;NOP56;NOP58;NUMA1;PTBP1;RANGAP1;RBFOX2;RBM10;SRSF1;TAF15;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;VIMNAT_cells_follicular_helperGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALING
chr4:2839245-2840254:+CESCEERENSG00000087266,SH3BP2-0.45905.4621e-125.1772e-14-0.4270imageNAIFM1;AUH;BCCIP;CELF2;DGCR8;EIF4A3;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHSRP;LIN28;LIN28B;MOV10;MSI2;NOP56;NOP58;NUMA1;PTBP1;RANGAP1;RBFOX2;RBM10;SRSF1;TAF15;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;VIMNAGSVA_HALLMARK_MYC_TARGETS_V1
chr4:2839245-2840254:+COADEERENSG00000267523,CTD-2537I9.12-0.24904.0793e-037.6604e-140.4529imageNFUS;NOP56;TAF15;UPF1NADendritic_cells_activatedGSVA_HALLMARK_ADIPOGENESIS
chr4:2839245-2840254:+COADEERENSG00000220205,VAMP20.22071.4058e-021.3094e-130.4490imageNAIFM1;AUH;BCCIP;CELF2;DGCR8;EIF4A3;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHSRP;LIN28;LIN28B;MOV10;MSI2;NOP56;NOP58;NUMA1;PTBP1;RANGAP1;RBFOX2;RBM10;SRSF1;TAF15;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;VIMNADendritic_cells_activatedGSVA_HALLMARK_MYC_TARGETS_V2
chr4:2839245-2840254:+GBMEERENSG00000087266,SH3BP2-0.47708.7074e-071.6906e-09-0.4537imageNAIFM1;AUH;BCCIP;CELF2;DGCR8;EIF4A3;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHSRP;LIN28;LIN28B;MOV10;MSI2;NOP56;NOP58;NUMA1;PTBP1;RANGAP1;RBFOX2;RBM10;SRSF1;TAF15;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;VIMNANK_cells_restingGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr4:2839245-2840254:+GBMEERENSG00000242858,CTC-484M2.10.41663.7178e-053.1796e-080.4202imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MYC_TARGETS_V1
chr4:2839245-2840254:+GBMEERENSG00000224858,RPL29P110.41145.3400e-051.0701e-080.4330imageNNNANK_cells_activatedGSVA_HALLMARK_APICAL_JUNCTION
chr4:2839245-2840254:+GBMEERENSG00000215482,CALM2P30.40467.2049e-056.5415e-080.4113imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr4:2839245-2840254:+GBMEERENSG00000231120,BTF3P100.40578.4119e-051.3600e-070.4021imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MYC_TARGETS_V1
chr4:2839245-2840254:+GBMEERENSG00000177855,CACYBPP20.40171.0665e-041.2248e-080.4315imageNNNANK_cells_restingGSVA_HALLMARK_APICAL_JUNCTION
chr4:2839245-2840254:+LGGEERENSG00000087266,SH3BP2-0.50341.5094e-251.9428e-34-0.5294imageNAIFM1;AUH;BCCIP;CELF2;DGCR8;EIF4A3;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHSRP;LIN28;LIN28B;MOV10;MSI2;NOP56;NOP58;NUMA1;PTBP1;RANGAP1;RBFOX2;RBM10;SRSF1;TAF15;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;VIMNAT_cells_follicular_helperGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALING
chr4:2839245-2840254:+CESCEERENSG00000087266,SH3BP2-0.45905.4621e-125.1772e-14-0.4270imageNAIFM1;AUH;BCCIP;CELF2;DGCR8;EIF4A3;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHSRP;LIN28;LIN28B;MOV10;MSI2;NOP56;NOP58;NUMA1;PTBP1;RANGAP1;RBFOX2;RBM10;SRSF1;TAF15;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;VIMNAGSVA_HALLMARK_MYC_TARGETS_V1
chr4:2839245-2840254:+COADEERENSG00000267523,CTD-2537I9.12-0.24904.0793e-037.6604e-140.4529imageNFUS;NOP56;TAF15;UPF1NADendritic_cells_activatedGSVA_HALLMARK_ADIPOGENESIS
chr4:2839245-2840254:+COADEERENSG00000220205,VAMP20.22071.4058e-021.3094e-130.4490imageNAIFM1;AUH;BCCIP;CELF2;DGCR8;EIF4A3;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHSRP;LIN28;LIN28B;MOV10;MSI2;NOP56;NOP58;NUMA1;PTBP1;RANGAP1;RBFOX2;RBM10;SRSF1;TAF15;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;VIMNADendritic_cells_activatedGSVA_HALLMARK_MYC_TARGETS_V2
chr4:2839245-2840254:+GBMEERENSG00000087266,SH3BP2-0.47708.7074e-071.6906e-09-0.4537imageNAIFM1;AUH;BCCIP;CELF2;DGCR8;EIF4A3;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHSRP;LIN28;LIN28B;MOV10;MSI2;NOP56;NOP58;NUMA1;PTBP1;RANGAP1;RBFOX2;RBM10;SRSF1;TAF15;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;VIMNANK_cells_restingGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr4:2839245-2840254:+GBMEERENSG00000242858,CTC-484M2.10.41663.7178e-053.1796e-080.4202imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MYC_TARGETS_V1
chr4:2839245-2840254:+GBMEERENSG00000224858,RPL29P110.41145.3400e-051.0701e-080.4330imageNNNANK_cells_activatedGSVA_HALLMARK_APICAL_JUNCTION
chr4:2839245-2840254:+GBMEERENSG00000215482,CALM2P30.40467.2049e-056.5415e-080.4113imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr4:2839245-2840254:+GBMEERENSG00000231120,BTF3P100.40578.4119e-051.3600e-070.4021imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MYC_TARGETS_V1
chr4:2839245-2840254:+GBMEERENSG00000177855,CACYBPP20.40171.0665e-041.2248e-080.4315imageNNNANK_cells_restingGSVA_HALLMARK_APICAL_JUNCTION

More results



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4. Enriched editing regions and immune related splicing for SH3BP2


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr4:2839245-2840254:+
COADEERIRENSG00000115211.11chr227369413:27369549:27369875:27369919-0.23842.2867e-022.1652e-120.4355imageNAIFM1;AUH;BCCIP;CELF2;DGCR8;EIF4A3;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHSRP;LIN28;LIN28B;MOV10;NOP56;NOP58;NUMA1;PTBP1;RANGAP1;RBFOX2;RBM10;SRSF1;TAF15;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1NADendritic_cells_activatedGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000087266.14,SH3BP2
COADEAGIRENSG00000115211.11chr227369413:27369549:27369875:27369919-0.23772.7043e-022.1563e-120.4356imageNADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YWHAG;ZNF184NADendritic_cells_activatedGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000087266.14,SH3BP2
COADEAGIRENSG00000167925.11chr1742192905:42193027:42193316:42193594-0.25201.5878e-024.2458e-120.4278imageNADAR;AIFM1;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX3X;DDX42;DGCR8;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;LARP4B;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TIA1;TNRC6A;TRA2A;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000087266.14,SH3BP2
COADEAGIRENSG00000162032.11chr161776711:1778321:1778434:1778612-0.40165.7207e-071.7660e-11-0.4180imageNADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAB_cells_memoryGSVA_HALLMARK_PROTEIN_SECRETION
chr4:2839245-2840254:+
COADEERIRENSG00000072778.15chr177221945:7223237:7223643:7223658-0.22763.9350e-022.9358e-120.4259imageNAIFM1;AUH;BCCIP;CELF2;DGCR8;EIF4A3;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHSRP;LIN28;LIN28B;MOV10;MSI2;NOP56;NOP58;NUMA1;PTBP1;RANGAP1;RBFOX2;RBM10;SRSF1;TAF15;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;VIMNADendritic_cells_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr4:2839245-2840254:+
COADEERIRENSG00000128159.7chr2250219956:50220015:50220250:50220416-0.33075.2260e-053.1439e-10-0.4012imageNAIFM1;AUH;BCCIP;CELF2;DGCR8;EIF4A3;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHSRP;LIN28;LIN28B;MOV10;MSI2;NOP56;NOP58;NUMA1;PTBP1;RANGAP1;RBFOX2;RBM10;SRSF1;TAF15;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;VIMNAB_cells_memoryGSVA_HALLMARK_ANDROGEN_RESPONSE
ENSG00000087266.14,SH3BP2
COADEAGIRENSG00000185627.13chr11251542:251936:252504:252617-0.22694.9018e-021.8246e-150.4783imageNADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184PSMD13Dendritic_cells_activatedGSVA_HALLMARK_UV_RESPONSE_UP
chr4:2839245-2840254:+
COADEERMEXENSG00000104522.11chr8143613769:143613817:143614163:143614195:143614335:143614453:143614623:143614697-0.25491.3320e-021.2821e-11-0.4142imageNAIFM1;AUH;BCCIP;DGCR8;EIF4A3;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHSRP;LIN28;LIN28B;MSI2;NOP56;NOP58;NUMA1;PTBP1;RANGAP1;RBFOX2;RBM10;SRSF1;TAF15;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1TSTA3EosinophilsGSVA_HALLMARK_DNA_REPAIR
ENSG00000087266.14,SH3BP2
COADEAGIRENSG00000148384.11chr9136431823:136433279:136434036:136434134-0.28811.4736e-042.9952e-09-0.4167imageNAIFM1;ALYREF;AUH;BCCIP;BUD13;CBX7;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZNF184NAB_cells_memoryGSVA_HALLMARK_PROTEIN_SECRETION
chr4:2839245-2840254:+
COADEERIRENSG00000167925.11chr1742192905:42193027:42193316:42193594-0.25181.3757e-024.0438e-120.4282imageNAIFM1;AUH;BCCIP;DGCR8;EIF4A3;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;LIN28;LIN28B;MOV10;MSI2;NOP56;NOP58;NUMA1;PTBP1;RANGAP1;RBFOX2;RBM10;SRSF1;TAF15;TIA1;U2AF1;U2AF2;UPF1NAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE

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5. Enriched editing regions and immune infiltration for SH3BP2


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr4:2839245-2840254:+BLCAEERDendritic_cells_activated1.0447e-06-0.2575image
ENSG00000087266.14,SH3BP2BLCAEAGDendritic_cells_activated1.2748e-06-0.2555image
chr4:2839245-2840254:+BRCAEERB_cells_naive1.1033e-02-0.0813image
ENSG00000087266.14,SH3BP2BRCAEAGB_cells_naive9.9685e-03-0.0825image
chr4:2839245-2840254:+CESCEERT_cells_CD4_memory_resting2.0800e-02-0.1371image
ENSG00000087266.14,SH3BP2CESCEAGT_cells_CD4_memory_resting2.2503e-02-0.1354image
chr4:2839245-2840254:+CHOLEERNK_cells_resting1.2344e-020.5128image
ENSG00000087266.14,SH3BP2CHOLEAGNK_cells_resting1.2385e-020.5126image
chr4:2839245-2840254:+COADEERDendritic_cells_activated6.9807e-030.1716image
ENSG00000087266.14,SH3BP2COADEAGDendritic_cells_activated5.9888e-030.1748image
chr4:2839245-2840254:+DLBCEERMast_cells_resting3.8093e-030.5203image
ENSG00000087266.14,SH3BP2DLBCEAGMast_cells_resting3.8093e-030.5203image
chr4:2839245-2840254:+ESCAEERB_cells_naive3.6686e-02-0.1669image
ENSG00000087266.14,SH3BP2ESCAEAGB_cells_naive4.4810e-02-0.1604image
chr4:2839245-2840254:+GBMEERNK_cells_activated1.1284e-030.2552image
ENSG00000087266.14,SH3BP2GBMEAGNK_cells_activated1.0313e-030.2571image
chr4:2839245-2840254:+HNSCEERT_cells_follicular_helper2.4492e-03-0.1491image
ENSG00000087266.14,SH3BP2HNSCEAGMacrophages_M22.4710e-030.1489image
chr4:2839245-2840254:+KICHEERMacrophages_M01.8336e-020.3324image
ENSG00000087266.14,SH3BP2KICHEAGMacrophages_M01.8151e-020.3329image
chr4:2839245-2840254:+KIRCEERB_cells_naive1.3221e-020.1272image
ENSG00000087266.14,SH3BP2KIRCEAGB_cells_naive1.3508e-020.1268image
chr4:2839245-2840254:+KIRPEERMast_cells_resting6.5733e-03-0.1641image
ENSG00000087266.14,SH3BP2KIRPEAGMast_cells_resting6.1576e-03-0.1654image
chr4:2839245-2840254:+LAMLEERDendritic_cells_activated1.1949e-050.3764image
ENSG00000087266.14,SH3BP2LAMLEAGDendritic_cells_activated1.2857e-050.3724image
ENSG00000087266.14,SH3BP2LGGEAGT_cells_follicular_helper4.9923e-020.0916image
chr4:2839245-2840254:+LIHCEEREosinophils3.3529e-030.1952image
ENSG00000087266.14,SH3BP2LIHCEAGEosinophils3.2189e-030.1960image
chr4:2839245-2840254:+LUADEERMacrophages_M01.7175e-02-0.1161image
ENSG00000087266.14,SH3BP2LUADEAGMacrophages_M01.9424e-02-0.1139image
chr4:2839245-2840254:+LUSCEERT_cells_CD4_memory_resting9.3992e-03-0.1253image
ENSG00000087266.14,SH3BP2LUSCEAGT_cells_CD4_memory_resting1.0022e-02-0.1242image
chr4:2839245-2840254:+MESOEERT_cells_gamma_delta1.7340e-030.3840image
ENSG00000087266.14,SH3BP2MESOEAGT_cells_gamma_delta1.7340e-030.3840image
chr4:2839245-2840254:+OVEERB_cells_memory2.4976e-020.1323image
ENSG00000087266.14,SH3BP2OVEAGMacrophages_M01.3703e-02-0.1454image
chr4:2839245-2840254:+PAADEERT_cells_gamma_delta5.8094e-030.2126image
ENSG00000087266.14,SH3BP2PAADEAGT_cells_gamma_delta5.1495e-030.2156image
chr4:2839245-2840254:+PCPGEERT_cells_CD81.0839e-030.2803image
ENSG00000087266.14,SH3BP2PCPGEAGT_cells_CD81.0737e-030.2805image
chr4:2839245-2840254:+PRADEERT_cells_follicular_helper8.5993e-03-0.1502image
ENSG00000087266.14,SH3BP2PRADEAGT_cells_follicular_helper1.0534e-02-0.1460image
chr4:2839245-2840254:+SARCEERDendritic_cells_activated1.8961e-020.1743image
ENSG00000087266.14,SH3BP2SARCEAGDendritic_cells_activated1.8716e-020.1746image
chr4:2839245-2840254:+SKCMEERT_cells_regulatory_(Tregs)2.2193e-020.1145image
ENSG00000087266.14,SH3BP2SKCMEAGT_cells_regulatory_(Tregs)2.1958e-020.1145image
chr4:2839245-2840254:+STADEERDendritic_cells_activated9.3351e-03-0.1392image
ENSG00000087266.14,SH3BP2STADEAGDendritic_cells_activated6.7951e-03-0.1449image
chr4:2839245-2840254:+TGCTEERT_cells_follicular_helper4.3524e-040.3088image
ENSG00000087266.14,SH3BP2TGCTEAGT_cells_follicular_helper4.2149e-040.3095image
chr4:2839245-2840254:+THCAEEREosinophils1.6007e-030.1505image
ENSG00000087266.14,SH3BP2THCAEAGEosinophils1.4768e-030.1516image
chr4:2839245-2840254:+THYMEERNeutrophils2.6414e-02-0.3385image
ENSG00000087266.14,SH3BP2THYMEAGNeutrophils2.6414e-02-0.3385image
chr4:2839245-2840254:+UCSEERT_cells_CD81.3108e-020.3594image
ENSG00000087266.14,SH3BP2UCSEAGT_cells_CD81.2199e-020.3628image
chr4:2839245-2840254:+UVMEERMonocytes1.4843e-040.5207image
ENSG00000087266.14,SH3BP2UVMEAGMonocytes1.4733e-040.5209image


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6. Enriched editing regions and immune gene sets for SH3BP2


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr4:2839245-2840254:+BLCAEER3.4789e-02image8.2133e-050.2089image
ENSG00000087266.14,SH3BP2BLCAEAG3.1564e-02image8.5955e-050.2084image
chr4:2839245-2840254:+HNSCEER1.6741e-02image2.3900e-050.2068image
ENSG00000087266.14,SH3BP2HNSCEAG1.8308e-02image2.4124e-050.2067image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000087266.14,SH3BP2ACCGSVA_HALLMARK_MYOGENESISEAG3.4383e-030.5957image
chr4:2839245-2840254:+ACCGSVA_HALLMARK_MYOGENESISEER2.6358e-030.6089image
chr4:2839245-2840254:+BLCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.9732e-100.3316image
ENSG00000087266.14,SH3BP2BLCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.9551e-100.3317image
chr4:2839245-2840254:+BRCAGSVA_HALLMARK_GLYCOLYSISEER2.4330e-080.1774image
ENSG00000087266.14,SH3BP2BRCAGSVA_HALLMARK_GLYCOLYSISEAG2.4259e-080.1774image
ENSG00000087266.14,SH3BP2CESCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.7713e-060.2791image
chr4:2839245-2840254:+CESCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.8469e-060.2737image
chr4:2839245-2840254:+CHOLGSVA_HALLMARK_E2F_TARGETSEER5.7880e-030.5568image
ENSG00000087266.14,SH3BP2CHOLGSVA_HALLMARK_E2F_TARGETSEAG5.0628e-030.5640image
ENSG00000087266.14,SH3BP2COADGSVA_HALLMARK_MYC_TARGETS_V2EAG2.0290e-04-0.2348image
chr4:2839245-2840254:+COADGSVA_HALLMARK_MYC_TARGETS_V2EER1.8521e-04-0.2362image
ENSG00000087266.14,SH3BP2DLBCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG3.4193e-040.6192image
chr4:2839245-2840254:+DLBCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER3.4193e-040.6192image
ENSG00000087266.14,SH3BP2ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG3.5671e-040.2814image
chr4:2839245-2840254:+ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER3.7392e-040.2805image
ENSG00000087266.14,SH3BP2GBMGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG6.7746e-040.2659image
chr4:2839245-2840254:+GBMGSVA_HALLMARK_PANCREAS_BETA_CELLSEER6.3168e-040.2673image
chr4:2839245-2840254:+HNSCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER2.2646e-050.2074image
ENSG00000087266.14,SH3BP2HNSCGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG2.4124e-050.2067image
chr4:2839245-2840254:+KICHGSVA_HALLMARK_P53_PATHWAYEER3.3109e-02-0.3019image
ENSG00000087266.14,SH3BP2KICHGSVA_HALLMARK_P53_PATHWAYEAG4.1163e-02-0.2899image
chr4:2839245-2840254:+KIRCGSVA_HALLMARK_PANCREAS_BETA_CELLSEER7.4134e-040.1726image
ENSG00000087266.14,SH3BP2KIRCGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG8.6072e-040.1705image
ENSG00000087266.14,SH3BP2KIRPGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.8565e-080.3281image
chr4:2839245-2840254:+KIRPGSVA_HALLMARK_PANCREAS_BETA_CELLSEER2.5410e-080.3292image
chr4:2839245-2840254:+LAMLGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEER7.7007e-05-0.3422image
ENSG00000087266.14,SH3BP2LAMLGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG7.0871e-05-0.3413image
ENSG00000087266.14,SH3BP2LGGGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG9.6557e-110.2961image
chr4:2839245-2840254:+LGGGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.4562e-100.2937image
chr4:2839245-2840254:+LIHCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER1.0275e-020.1712image
ENSG00000087266.14,SH3BP2LIHCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG9.3981e-030.1732image
chr4:2839245-2840254:+LUADGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.1648e-050.2119image
ENSG00000087266.14,SH3BP2LUADGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG7.0353e-060.2170image
chr4:2839245-2840254:+LUSCGSVA_HALLMARK_MTORC1_SIGNALINGEER2.1500e-050.2036image
ENSG00000087266.14,SH3BP2LUSCGSVA_HALLMARK_MTORC1_SIGNALINGEAG1.7973e-050.2054image
chr4:2839245-2840254:+OVGSVA_HALLMARK_DNA_REPAIREER6.9383e-040.1991image
ENSG00000087266.14,SH3BP2OVGSVA_HALLMARK_DNA_REPAIREAG2.4774e-030.1780image
ENSG00000087266.14,SH3BP2PAADGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.8026e-03-0.2299image
chr4:2839245-2840254:+PAADGSVA_HALLMARK_MITOTIC_SPINDLEEER3.7959e-03-0.2228image
chr4:2839245-2840254:+PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.6284e-030.2506image
ENSG00000087266.14,SH3BP2PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.5726e-030.2510image
chr4:2839245-2840254:+PRADGSVA_HALLMARK_FATTY_ACID_METABOLISMEER6.9614e-060.2542image
ENSG00000087266.14,SH3BP2PRADGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG7.0747e-060.2536image
ENSG00000087266.14,SH3BP2READGSVA_HALLMARK_NOTCH_SIGNALINGEAG5.7250e-030.2939image
chr4:2839245-2840254:+READGSVA_HALLMARK_NOTCH_SIGNALINGEER5.7084e-030.2940image
chr4:2839245-2840254:+SARCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER1.7704e-02-0.1761image
ENSG00000087266.14,SH3BP2SARCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG1.6191e-02-0.1785image
chr4:2839245-2840254:+SKCMGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER3.2401e-060.2306image
ENSG00000087266.14,SH3BP2SKCMGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG3.3703e-060.2299image
ENSG00000087266.14,SH3BP2STADGSVA_HALLMARK_NOTCH_SIGNALINGEAG6.0392e-070.2637image
chr4:2839245-2840254:+STADGSVA_HALLMARK_NOTCH_SIGNALINGEER2.6935e-070.2715image
ENSG00000087266.14,SH3BP2TGCTGSVA_HALLMARK_DNA_REPAIREAG4.7193e-070.4310image
chr4:2839245-2840254:+TGCTGSVA_HALLMARK_DNA_REPAIREER4.7854e-070.4308image
chr4:2839245-2840254:+THCAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.1820e-110.3170image
ENSG00000087266.14,SH3BP2THCAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.0574e-110.3177image
ENSG00000087266.14,SH3BP2UCECGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG3.1335e-070.4307image
chr4:2839245-2840254:+UCECGSVA_HALLMARK_FATTY_ACID_METABOLISMEER4.4663e-070.4271image
ENSG00000087266.14,SH3BP2UCSGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.9192e-030.4410image
chr4:2839245-2840254:+UCSGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.7085e-030.4453image


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7. Enriched editing regions and drugs for SH3BP2


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr4:2839245-2840254:+BLCAGNF.2EER1.6772e-07-0.2752image
ENSG00000087266.14,SH3BP2BLCAGNF.2EAG1.7146e-07-0.2750image
chr4:2839245-2840254:+BRCAABT.263EER3.4986e-050.1323image
ENSG00000087266.14,SH3BP2BRCAABT.263EAG3.8604e-050.1315image
ENSG00000087266.14,SH3BP2CESCA.770041EAG5.6193e-07-0.2917image
chr4:2839245-2840254:+CESCA.770041EER7.0031e-07-0.2894image
chr4:2839245-2840254:+COADGW843682XEER9.4491e-060.2782image
ENSG00000087266.14,SH3BP2COADGW843682XEAG9.0165e-060.2788image
ENSG00000087266.14,SH3BP2DLBCAZD6482EAG1.2316e-030.5795image
chr4:2839245-2840254:+DLBCAZD6482EER1.2316e-030.5795image
chr4:2839245-2840254:+ESCADocetaxelEER1.2861e-03-0.2547image
ENSG00000087266.14,SH3BP2ESCADocetaxelEAG9.9817e-04-0.2602image
ENSG00000087266.14,SH3BP2GBMFTI.277EAG1.9056e-040.2909image
chr4:2839245-2840254:+GBMFTI.277EER2.2011e-040.2881image
chr4:2839245-2840254:+HNSCDoxorubicinEER5.9298e-050.1967image
ENSG00000087266.14,SH3BP2HNSCDoxorubicinEAG6.0594e-050.1965image
chr4:2839245-2840254:+KICHErlotinibEER3.9725e-020.2919image
ENSG00000087266.14,SH3BP2KICHGefitinibEAG3.7314e-020.2954image
chr4:2839245-2840254:+KIRCFH535EER9.9654e-05-0.1986image
ENSG00000087266.14,SH3BP2KIRCFH535EAG1.0213e-04-0.1983image
ENSG00000087266.14,SH3BP2KIRPAxitinibEAG1.3671e-05-0.2599image
chr4:2839245-2840254:+KIRPAxitinibEER1.4628e-05-0.2590image
ENSG00000087266.14,SH3BP2LAMLEtoposideEAG2.2801e-04-0.3179image
chr4:2839245-2840254:+LAMLEtoposideEER2.5178e-04-0.3182image
ENSG00000087266.14,SH3BP2LGGAZD6482EAG1.1550e-120.3238image
chr4:2839245-2840254:+LGGAZD6482EER2.1251e-120.3205image
ENSG00000087266.14,SH3BP2LIHCIPA.3EAG1.2323e-020.1674image
chr4:2839245-2840254:+LIHCIPA.3EER1.1385e-020.1692image
chr4:2839245-2840254:+LUADBleomycinEER1.7018e-03-0.1525image
ENSG00000087266.14,SH3BP2LUADBleomycinEAG1.2275e-03-0.1570image
chr4:2839245-2840254:+LUSCMethotrexateEER1.2122e-050.2107image
ENSG00000087266.14,SH3BP2LUSCMethotrexateEAG1.3823e-050.2094image
chr4:2839245-2840254:+MESOAP.24534EER3.4377e-020.2649image
ENSG00000087266.14,SH3BP2MESOAP.24534EAG3.4377e-020.2649image
ENSG00000087266.14,SH3BP2OVGefitinibEAG6.7240e-040.1999image
chr4:2839245-2840254:+OVAICAREER1.8903e-030.1826image
chr4:2839245-2840254:+PAADBleomycinEER6.4894e-070.3738image
ENSG00000087266.14,SH3BP2PAADBleomycinEAG6.0985e-070.3746image
ENSG00000087266.14,SH3BP2PCPGBMS.708163EAG2.9172e-03-0.2562image
chr4:2839245-2840254:+PCPGBMS.708163EER2.7930e-03-0.2573image
chr4:2839245-2840254:+PRADLenalidomideEER2.3665e-040.2090image
ENSG00000087266.14,SH3BP2PRADLenalidomideEAG3.1130e-040.2048image
chr4:2839245-2840254:+READEmbelinEER2.4021e-02-0.2418image
ENSG00000087266.14,SH3BP2READEmbelinEAG2.4516e-02-0.2410image
chr4:2839245-2840254:+SARCMetforminEER3.6638e-02-0.1555image
ENSG00000087266.14,SH3BP2SARCMetforminEAG3.9379e-02-0.1533image
ENSG00000087266.14,SH3BP2SKCMDoxorubicinEAG3.8855e-050.2042image
chr4:2839245-2840254:+SKCMDoxorubicinEER3.9324e-050.2043image
ENSG00000087266.14,SH3BP2STADAZD8055EAG5.5499e-05-0.2144image
chr4:2839245-2840254:+STADAZD8055EER3.2179e-05-0.2209image
ENSG00000087266.14,SH3BP2TGCTAKT.inhibitor.VIIIEAG3.3947e-050.3604image
chr4:2839245-2840254:+TGCTAKT.inhibitor.VIIIEER3.4412e-050.3601image
chr4:2839245-2840254:+THCACHIR.99021EER7.1416e-150.3607image
ENSG00000087266.14,SH3BP2THCACHIR.99021EAG4.1240e-150.3637image
chr4:2839245-2840254:+UCECLenalidomideEER1.2211e-030.2817image
ENSG00000087266.14,SH3BP2UCECLenalidomideEAG1.1151e-030.2828image
chr4:2839245-2840254:+UCSMG.132EER2.4104e-03-0.4323image
ENSG00000087266.14,SH3BP2UCSMG.132EAG2.5316e-03-0.4304image
ENSG00000087266.14,SH3BP2UVMAZ628EAG9.2915e-04-0.4627image
chr4:2839245-2840254:+UVMAZ628EER9.3966e-04-0.4623image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType