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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: RBSN (ImmuneEditome ID:64145)

1. Gene summary of enriched editing regions for RBSN

check button Gene summary
Gene informationGene symbol

RBSN

Gene ID

64145

GeneSynonymsRabenosyn-5|ZFYVE20
GeneCytomap

3p25.1

GeneTypeprotein-coding
GeneDescriptionrabenosyn-5|110 kDa protein|FYVE finger-containing Rab5 effector protein rabenosyn-5|RAB effector RBSN|zinc finger, FYVE domain containing 20
GeneModificationdate20230517
UniprotIDQ9H1K0;F8WE50;C9JZZ1;D6RD50
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr3:15072099-15073034:-ENST00000253699.6ENSG00000131381.11RBSNUTR3AluY,AluSz6chr3:15072099-15073034:-.alignment
chr3:15087709-15087921:-ENST00000449964.5ENSG00000131381.11RBSNncRNA_intronicAluSz6chr3:15087709-15087921:-.alignment


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2. Tumor-specific enriched editing regions for RBSN


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr3:15072099-15073034:-BRCAEER8.1619e-30image
ENSG00000131381.11,RBSNBRCAEAG1.3672e-27image
chr3:15072099-15073034:-COADEER3.3543e-05image
ENSG00000131381.11,RBSNCOADEAG5.0012e-05image
chr3:15072099-15073034:-HNSCEER3.3175e-08image
ENSG00000131381.11,RBSNHNSCEAG5.8320e-07image
chr3:15072099-15073034:-KIRCEER1.6692e-09image
ENSG00000131381.11,RBSNKIRCEAG4.6439e-09image
chr3:15072099-15073034:-LUADEER3.1505e-06image
ENSG00000131381.11,RBSNLUADEAG1.7617e-05image
chr3:15072099-15073034:-LUSCEER5.8825e-17image
ENSG00000131381.11,RBSNLUSCEAG2.7083e-16image
chr3:15072099-15073034:-PRADEER1.3766e-05image
ENSG00000131381.11,RBSNPRADEAG1.3854e-08image
chr3:15072099-15073034:-STADEER5.5114e-03image
ENSG00000131381.11,RBSNSTADEAG3.2148e-02image
chr3:15072099-15073034:-THCAEER1.9680e-07image
ENSG00000131381.11,RBSNTHCAEAG9.2032e-08image
chr3:15072099-15073034:-UCECEER7.9170e-10image
ENSG00000131381.11,RBSNUCECEAG3.7596e-09image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000131381.11,RBSNBLCAPathEAG1.4623e-024.2363e-020.1116image
chr3:15072099-15073034:-BLCAPathEER8.0144e-034.1991e-020.1134image
chr3:15072099-15073034:-ESCACliEER3.2372e-022.1079e-02-0.3192image
ENSG00000131381.11,RBSNESCACliEAG7.2811e-032.8440e-03-0.4057image
chr3:15072099-15073034:-KIRCPathEER1.1724e-021.5188e-030.1479image
ENSG00000131381.11,RBSNKIRCPathEAG1.5552e-022.4151e-030.1416image
ENSG00000131381.11,RBSNKIRPCliEAG1.8350e-021.7182e-030.2703image
chr3:15072099-15073034:-KIRPCliEER1.1211e-028.8803e-040.2881image
chr3:15072099-15073034:-LUADPathEER1.9061e-021.0543e-020.1174image
ENSG00000131381.11,RBSNLUADPathEAG3.3203e-021.0740e-020.1170image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for RBSN


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr3:15072099-15073034:-PRADEERENSG00000107223,EDF10.33981.2459e-101.6987e-190.4116imageNEIF4A3;ELAVL1;FUS;IGF2BP2;NOP56;NOP58;RBM10;U2AF2NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr3:15072099-15073034:-PRADEERENSG00000273437,RP11-434H6.70.32638.1595e-101.8955e-220.4409imageNELAVL1;NOP58;U2AF2NAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr3:15072099-15073034:-PRADEERENSG00000123349,PFDN50.32419.0731e-103.0106e-200.4193imageNEIF4A3;ELAVL1;IGF2BP2;NOP56;NOP58;RBM10;U2AF2NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr3:15072099-15073034:-HNSCEERENSG00000177463,NR2C2-0.37433.1235e-125.3935e-18-0.4048imageNEIF4A3;ELAVL1;FUS;IGF2BP2;NOP56;NOP58;RBM10;U2AF2NAB_cells_naiveGSVA_HALLMARK_MITOTIC_SPINDLE
chr3:15072099-15073034:-STADEERENSG00000177463,NR2C2-0.39823.5308e-105.8731e-14-0.4000imageNEIF4A3;ELAVL1;FUS;IGF2BP2;NOP56;NOP58;RBM10;U2AF2NAB_cells_memoryGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr3:15072099-15073034:-THCAEERENSG00000107290,SETX-0.42974.8570e-206.3965e-24-0.4376imageNEIF4A3;ELAVL1;FUS;IGF2BP2;NOP56;NOP58;RBM10;U2AF2NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN
chr3:15072099-15073034:-THCAEERENSG00000124422,USP22-0.42403.5757e-194.2871e-27-0.4643imageNEIF4A3;ELAVL1;FUS;IGF2BP2;NOP56;NOP58;RBM10;U2AF2NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN
chr3:15072099-15073034:-THCAEERENSG00000268043,NBPF12-0.42344.1228e-198.8370e-23-0.4274imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr3:15072099-15073034:-THCAEERENSG00000103657,HERC1-0.41669.4201e-192.2316e-24-0.4416imageNEIF4A3;ELAVL1;FUS;IGF2BP2;NOP56;NOP58;RBM10;U2AF2NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN
chr3:15072099-15073034:-THCAEERENSG00000006432,MAP3K9-0.41771.1779e-185.2495e-20-0.4010imageNEIF4A3;ELAVL1;FUS;IGF2BP2;NOP56;NOP58;RBM10;U2AF2NANeutrophilsGSVA_HALLMARK_ALLOGRAFT_REJECTION

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4. Enriched editing regions and immune related splicing for RBSN


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr3:15072099-15073034:-
ESCAEERIRENSG00000128309.12chr2237024191:37024810:37026998:37027053-0.35216.6258e-035.2906e-07-0.4102imageNEIF4A3;ELAVL1;FUS;IGF2BP2;NOP56;NOP58;RBM10;U2AF2NAT_cells_CD4_memory_restingGSVA_HALLMARK_MTORC1_SIGNALING
ENSG00000131381.11,RBSN
ESCAEAGIRENSG00000184083.7chrX54173788:54174146:54182499:54182778-0.30621.3735e-023.0798e-06-0.4144imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM47;RC3H1;RNF219;SAFB2;SF3A3;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;YTHDC1;YTHDF1;ZC3H7B;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_MTORC1_SIGNALING
chr3:15072099-15073034:-
ESCAEERIRENSG00000006607.9chr2241492928:241493444:241494007:241494119-0.35835.2014e-039.4157e-07-0.4005imageNEIF4A3;ELAVL1;FUS;IGF2BP2;NOP56;NOP58;RBM10;U2AF2NAT_cells_CD4_memory_restingGSVA_HALLMARK_P53_PATHWAY
chr3:15072099-15073034:-
ESCAEERESENSG00000154380.12chr1225514595:225514900:225517195:225517990:225519197:225519274-0.35761.0592e-021.8584e-07-0.4052imageNEIF4A3;ELAVL1;FUS;IGF2BP2;NOP56;NOP58;RBM10;U2AF2NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr3:15072099-15073034:-
ESCAEERIRENSG00000148688.9chr1090902242:90903276:90905301:90905638-0.36853.0196e-033.6587e-07-0.4169imageNEIF4A3;ELAVL1;FUS;IGF2BP2;NOP56;NOP58;RBM10;U2AF2NAMast_cells_restingGSVA_HALLMARK_MYC_TARGETS_V1
chr3:15072099-15073034:-
ESCAEERIRENSG00000115289.8chr274505042:74505638:74505736:74505770-0.42466.8030e-045.5743e-09-0.4418imageNEIF4A3;ELAVL1;FUS;IGF2BP2;NOP56;NOP58;RBM10;U2AF2NAB_cells_naiveGSVA_HALLMARK_HYPOXIA
ENSG00000131381.11,RBSN
ESCAEAGIRENSG00000204856.7chr12110486324:110486454:110486533:110486700-0.32456.3938e-032.1109e-06-0.4158imageNADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YWHAG;ZNF184NAMacrophages_M2GSVA_HALLMARK_UV_RESPONSE_UP
chr3:15072099-15073034:-
ESCAEERIRENSG00000165275.5chr937773305:37776405:37777600:37778022-0.43562.2200e-042.0324e-10-0.4882imageNEIF4A3;ELAVL1;FUS;IGF2BP2;NOP56;NOP58;RBM10;U2AF2NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MTORC1_SIGNALING
ENSG00000131381.11,RBSN
ESCAEAGIRENSG00000189046.6chr12109092506:109092787:109093246:109093459-0.38062.4964e-033.3116e-07-0.4114imageNACIN1;ADAR;AIFM1;BCCIP;BUD13;CAPRIN1;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28B;LSM11;MOV10;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RNF219;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;U2AF1;U2AF2;UPF1;XRN2;YTHDF1;ZC3H7B;ZNF184NAMacrophages_M2GSVA_HALLMARK_UV_RESPONSE_UP
chr3:15072099-15073034:-
ESCAEERIRENSG00000184083.7chrX54173788:54174146:54182499:54182778-0.31399.1370e-031.1762e-06-0.4317imageNEIF4A3;ELAVL1;FUS;IGF2BP2;NOP56;NOP58;RBM10;U2AF2NAT_cells_CD4_memory_restingGSVA_HALLMARK_MTORC1_SIGNALING

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5. Enriched editing regions and immune infiltration for RBSN


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr3:15072099-15073034:-BLCAEERT_cells_CD4_memory_activated1.4556e-040.2104image
ENSG00000131381.11,RBSNBLCAEAGMacrophages_M17.1153e-040.1854image
chr3:15072099-15073034:-BRCAEERNK_cells_activated6.1320e-080.1685image
ENSG00000131381.11,RBSNBRCAEAGNK_cells_activated4.2118e-070.1573image
chr3:15072099-15073034:-CESCEERT_cells_CD4_memory_resting8.4777e-03-0.1658image
ENSG00000131381.11,RBSNCESCEAGT_cells_CD83.5771e-020.1308image
chr3:15072099-15073034:-CHOLEERPlasma_cells2.1974e-020.4856image
ENSG00000131381.11,RBSNCHOLEAGPlasma_cells1.1823e-020.5265image
chr3:15072099-15073034:-DLBCEERMacrophages_M19.7525e-030.5630image
ENSG00000131381.11,RBSNDLBCEAGMacrophages_M12.0495e-020.5017image
chr3:15072099-15073034:-ESCAEERMacrophages_M02.9653e-050.3247image
ENSG00000131381.11,RBSNESCAEAGMacrophages_M01.5130e-040.2952image
chr3:15072099-15073034:-GBMEERMacrophages_M01.7214e-03-0.2422image
ENSG00000131381.11,RBSNGBMEAGMacrophages_M03.8627e-03-0.2238image
chr3:15072099-15073034:-HNSCEERT_cells_regulatory_(Tregs)1.8771e-03-0.1513image
ENSG00000131381.11,RBSNHNSCEAGB_cells_naive2.1663e-03-0.1480image
chr3:15072099-15073034:-KICHEERT_cells_CD87.3098e-040.4620image
ENSG00000131381.11,RBSNKICHEAGT_cells_CD87.3098e-040.4620image
chr3:15072099-15073034:-KIRCEERT_cells_gamma_delta2.7610e-040.1978image
ENSG00000131381.11,RBSNKIRCEAGT_cells_gamma_delta2.0704e-040.2017image
chr3:15072099-15073034:-KIRPEERNeutrophils1.3054e-030.2275image
ENSG00000131381.11,RBSNKIRPEAGNeutrophils1.1784e-030.2284image
chr3:15072099-15073034:-LAMLEERT_cells_CD4_memory_activated1.7864e-020.3212image
ENSG00000131381.11,RBSNLAMLEAGT_cells_CD4_memory_activated1.2541e-040.4863image
chr3:15072099-15073034:-LGGEERMacrophages_M11.9406e-050.1856image
ENSG00000131381.11,RBSNLGGEAGMacrophages_M12.2960e-040.1604image
chr3:15072099-15073034:-LIHCEERNK_cells_activated1.7863e-040.2479image
ENSG00000131381.11,RBSNLIHCEAGNK_cells_activated1.7759e-030.2028image
chr3:15072099-15073034:-LUADEERT_cells_CD4_memory_activated3.3061e-070.2326image
ENSG00000131381.11,RBSNLUADEAGT_cells_CD4_memory_activated6.6375e-060.2057image
chr3:15072099-15073034:-LUSCEERT_cells_CD4_memory_resting2.0355e-03-0.1454image
ENSG00000131381.11,RBSNLUSCEAGT_cells_CD4_memory_resting2.2453e-03-0.1440image
chr3:15072099-15073034:-MESOEERMast_cells_resting9.7610e-03-0.3048image
ENSG00000131381.11,RBSNMESOEAGMast_cells_resting2.2700e-02-0.2683image
chr3:15072099-15073034:-OVEERT_cells_CD84.6942e-040.2209image
chr3:15072099-15073034:-PAADEERT_cells_regulatory_(Tregs)7.1354e-050.3174image
ENSG00000131381.11,RBSNPAADEAGT_cells_regulatory_(Tregs)7.6993e-040.2691image
chr3:15072099-15073034:-PCPGEERNK_cells_resting3.0145e-020.1833image
ENSG00000131381.11,RBSNPCPGEAGPlasma_cells2.2893e-020.1915image
chr3:15072099-15073034:-PRADEERNeutrophils3.8127e-03-0.1373image
ENSG00000131381.11,RBSNPRADEAGNeutrophils6.0282e-03-0.1301image
chr3:15072099-15073034:-READEERMacrophages_M01.1588e-020.2726image
ENSG00000131381.11,RBSNREADEAGMacrophages_M01.1588e-020.2726image
chr3:15072099-15073034:-SARCEERT_cells_CD4_memory_activated1.3410e-030.2140image
ENSG00000131381.11,RBSNSARCEAGT_cells_CD4_memory_activated1.5438e-030.2094image
chr3:15072099-15073034:-SKCMEERT_cells_CD81.3296e-030.1543image
ENSG00000131381.11,RBSNSKCMEAGT_cells_CD82.3281e-030.1463image
chr3:15072099-15073034:-STADEERT_cells_CD4_memory_resting1.5671e-05-0.2367image
ENSG00000131381.11,RBSNSTADEAGT_cells_CD4_memory_resting5.6557e-04-0.1879image
chr3:15072099-15073034:-TGCTEERMacrophages_M29.6199e-04-0.2820image
ENSG00000131381.11,RBSNTGCTEAGMacrophages_M21.4940e-03-0.2707image
chr3:15072099-15073034:-THCAEERDendritic_cells_resting1.4544e-020.1114image
ENSG00000131381.11,RBSNTHCAEAGDendritic_cells_resting1.4280e-020.1115image
chr3:15072099-15073034:-THYMEERT_cells_CD4_memory_activated3.4568e-020.2567image
ENSG00000131381.11,RBSNTHYMEAGT_cells_CD4_memory_activated1.1203e-020.3015image
chr3:15072099-15073034:-UCECEERDendritic_cells_activated5.0391e-040.3116image
ENSG00000131381.11,RBSNUCECEAGDendritic_cells_activated8.4441e-040.2914image
chr3:15072099-15073034:-UCSEERNeutrophils6.0430e-030.4075image
ENSG00000131381.11,RBSNUCSEAGNeutrophils5.7062e-030.4100image


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6. Enriched editing regions and immune gene sets for RBSN


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr3:15072099-15073034:-BRCAEER6.0753e-140.23208.9246e-050.12237.0901e-060.14001.0508e-030.1024image
ENSG00000131381.11,RBSNBRCAEAG2.5533e-110.20643.1774e-040.11231.1102e-040.12052.6450e-030.0938image
ENSG00000131381.11,RBSNESCAEAG8.5197e-090.43573.2664e-020.16901.0464e-090.45886.7714e-060.3474image
chr3:15072099-15073034:-ESCAEER5.4728e-100.46701.4289e-020.19402.2165e-110.49883.3754e-060.3590image
chr3:15072099-15073034:-LUADEER4.3493e-100.28241.7519e-080.25603.6587e-080.25038.7548e-060.2032image
ENSG00000131381.11,RBSNLUADEAG1.1293e-080.25908.4748e-080.24354.5704e-070.22967.3146e-050.1815image
ENSG00000131381.11,RBSNSTADEAG3.0056e-090.31783.0667e-040.19661.3260e-050.23627.0044e-030.1475image
chr3:15072099-15073034:-STADEER5.8284e-100.33451.3929e-040.20946.5113e-060.24681.0482e-020.1416image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr3:15072099-15073034:-ACCGSVA_HALLMARK_UV_RESPONSE_DNEER3.8090e-02-0.2830image
ENSG00000131381.11,RBSNACCGSVA_HALLMARK_UV_RESPONSE_DNEAG2.0878e-02-0.3109image
chr3:15072099-15073034:-BLCAGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER2.5517e-100.3435image
ENSG00000131381.11,RBSNBLCAGSVA_HALLMARK_HYPOXIAEAG3.4848e-060.2522image
chr3:15072099-15073034:-BRCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.4193e-290.3431image
ENSG00000131381.11,RBSNBRCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.4998e-230.3040image
ENSG00000131381.11,RBSNCESCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG2.7505e-030.1857image
chr3:15072099-15073034:-CESCGSVA_HALLMARK_COMPLEMENTEER7.5553e-060.2784image
ENSG00000131381.11,RBSNCOADGSVA_HALLMARK_MITOTIC_SPINDLEEAG5.7648e-03-0.1770image
chr3:15072099-15073034:-COADGSVA_HALLMARK_MITOTIC_SPINDLEEER5.2032e-03-0.1791image
chr3:15072099-15073034:-DLBCGSVA_HALLMARK_PANCREAS_BETA_CELLSEER7.6081e-030.5780image
ENSG00000131381.11,RBSNDLBCGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.6277e-020.5175image
ENSG00000131381.11,RBSNESCAGSVA_HALLMARK_HYPOXIAEAG6.7714e-060.3474image
chr3:15072099-15073034:-ESCAGSVA_HALLMARK_HYPOXIAEER3.3754e-060.3590image
chr3:15072099-15073034:-GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.4376e-060.3650image
ENSG00000131381.11,RBSNGBMGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.3671e-05-0.3315image
chr3:15072099-15073034:-HNSCGSVA_HALLMARK_P53_PATHWAYEER5.9068e-060.2190image
ENSG00000131381.11,RBSNHNSCGSVA_HALLMARK_P53_PATHWAYEAG1.4718e-040.1827image
chr3:15072099-15073034:-KICHGSVA_HALLMARK_PROTEIN_SECRETIONEER2.4025e-04-0.4971image
ENSG00000131381.11,RBSNKICHGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.4025e-04-0.4971image
chr3:15072099-15073034:-KIRCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER4.8053e-060.2473image
ENSG00000131381.11,RBSNKIRCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.9302e-060.2571image
chr3:15072099-15073034:-KIRPGSVA_HALLMARK_GLYCOLYSISEER2.2486e-020.1625image
ENSG00000131381.11,RBSNKIRPGSVA_HALLMARK_GLYCOLYSISEAG2.1909e-020.1624image
chr3:15072099-15073034:-LGGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.0694e-210.4017image
ENSG00000131381.11,RBSNLGGGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG8.0294e-240.4205image
ENSG00000131381.11,RBSNLIHCGSVA_HALLMARK_PEROXISOMEEAG5.0172e-030.1825image
chr3:15072099-15073034:-LIHCGSVA_HALLMARK_PEROXISOMEEER2.8187e-030.1987image
chr3:15072099-15073034:-LUADGSVA_HALLMARK_GLYCOLYSISEER7.5766e-110.2940image
ENSG00000131381.11,RBSNLUADGSVA_HALLMARK_GLYCOLYSISEAG1.8668e-090.2721image
ENSG00000131381.11,RBSNLUSCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG2.1814e-03-0.1444image
chr3:15072099-15073034:-LUSCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER3.5798e-04-0.1679image
ENSG00000131381.11,RBSNMESOGSVA_HALLMARK_KRAS_SIGNALING_UPEAG3.3238e-020.2513image
chr3:15072099-15073034:-MESOGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER1.4759e-020.2883image
chr3:15072099-15073034:-OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.4011e-070.3274image
ENSG00000131381.11,RBSNOVGSVA_HALLMARK_DNA_REPAIREAG1.6983e-020.1485image
ENSG00000131381.11,RBSNPAADGSVA_HALLMARK_P53_PATHWAYEAG3.3929e-030.2354image
chr3:15072099-15073034:-PAADGSVA_HALLMARK_P53_PATHWAYEER4.2222e-040.2834image
ENSG00000131381.11,RBSNPCPGGSVA_HALLMARK_G2M_CHECKPOINTEAG4.7391e-03-0.2366image
chr3:15072099-15073034:-PCPGGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER4.3154e-040.2936image
chr3:15072099-15073034:-PRADGSVA_HALLMARK_MITOTIC_SPINDLEEER2.0595e-11-0.3117image
ENSG00000131381.11,RBSNPRADGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.4283e-09-0.2822image
ENSG00000131381.11,RBSNSARCGSVA_HALLMARK_HYPOXIAEAG1.7169e-100.4083image
chr3:15072099-15073034:-SARCGSVA_HALLMARK_GLYCOLYSISEER9.7024e-120.4364image
chr3:15072099-15073034:-SKCMGSVA_HALLMARK_UV_RESPONSE_DNEER1.3012e-07-0.2512image
ENSG00000131381.11,RBSNSKCMGSVA_HALLMARK_UV_RESPONSE_DNEAG2.7704e-06-0.2236image
ENSG00000131381.11,RBSNSTADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG5.9801e-080.2916image
chr3:15072099-15073034:-STADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER6.1231e-090.3150image
chr3:15072099-15073034:-TGCTGSVA_HALLMARK_DNA_REPAIREER2.8904e-060.3916image
ENSG00000131381.11,RBSNTGCTGSVA_HALLMARK_DNA_REPAIREAG1.3124e-050.3654image
chr3:15072099-15073034:-THCAGSVA_HALLMARK_UV_RESPONSE_DNEER6.5338e-11-0.2920image
ENSG00000131381.11,RBSNTHCAGSVA_HALLMARK_UV_RESPONSE_DNEAG7.1774e-11-0.2911image
chr3:15072099-15073034:-THYMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER6.1117e-030.3293image
ENSG00000131381.11,RBSNTHYMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG6.8209e-030.3206image
chr3:15072099-15073034:-UCECGSVA_HALLMARK_MITOTIC_SPINDLEEER3.3623e-03-0.2646image
ENSG00000131381.11,RBSNUCECGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.3503e-02-0.2178image
ENSG00000131381.11,RBSNUCSGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG3.4220e-02-0.3200image
ENSG00000131381.11,RBSNUVMGSVA_HALLMARK_P53_PATHWAYEAG1.4764e-030.4463image
chr3:15072099-15073034:-UVMGSVA_HALLMARK_COAGULATIONEER6.1436e-040.4767image


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7. Enriched editing regions and drugs for RBSN


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr3:15072099-15073034:-ACCABT.263EER9.1551e-030.3515image
ENSG00000131381.11,RBSNACCDMOGEAG4.2015e-020.2752image
chr3:15072099-15073034:-BLCACMKEER6.6109e-10-0.3359image
ENSG00000131381.11,RBSNBLCACisplatinEAG6.0900e-07-0.2705image
chr3:15072099-15073034:-BRCACCT007093EER1.8320e-190.2772image
ENSG00000131381.11,RBSNBRCACCT007093EAG4.5201e-140.2328image
ENSG00000131381.11,RBSNCESCDMOGEAG2.1759e-02-0.1428image
chr3:15072099-15073034:-CESCCI.1040EER3.1832e-04-0.2254image
chr3:15072099-15073034:-CHOLCamptothecinEER9.7105e-03-0.5386image
ENSG00000131381.11,RBSNCHOLJNJ.26854165EAG3.1536e-02-0.4593image
ENSG00000131381.11,RBSNCOADAS601245EAG1.0062e-030.2101image
chr3:15072099-15073034:-COADAS601245EER9.1730e-040.2118image
chr3:15072099-15073034:-DLBCAZD.2281EER3.5412e-02-0.4725image
ENSG00000131381.11,RBSNESCADocetaxelEAG2.0750e-04-0.2892image
chr3:15072099-15073034:-ESCADocetaxelEER1.1744e-05-0.3398image
chr3:15072099-15073034:-GBMCyclopamineEER1.0797e-05-0.3352image
ENSG00000131381.11,RBSNGBMCyclopamineEAG1.2318e-05-0.3331image
chr3:15072099-15073034:-HNSCABT.263EER2.8898e-080.2669image
ENSG00000131381.11,RBSNHNSCABT.263EAG2.1176e-070.2482image
chr3:15072099-15073034:-KICHAKT.inhibitor.VIIIEER2.6480e-030.4162image
ENSG00000131381.11,RBSNKICHAKT.inhibitor.VIIIEAG2.6480e-030.4162image
chr3:15072099-15073034:-KIRCBAY.61.3606EER9.3600e-070.2646image
ENSG00000131381.11,RBSNKIRCBAY.61.3606EAG2.1133e-060.2561image
chr3:15072099-15073034:-KIRPErlotinibEER1.9707e-02-0.1660image
ENSG00000131381.11,RBSNKIRPErlotinibEAG1.9970e-02-0.1649image
chr3:15072099-15073034:-LGGBAY.61.3606EER4.3162e-350.5043image
ENSG00000131381.11,RBSNLGGBAY.61.3606EAG5.9553e-360.5099image
ENSG00000131381.11,RBSNLIHCIPA.3EAG2.7336e-030.1950image
chr3:15072099-15073034:-LIHCBMS.754807EER1.7824e-030.2086image
chr3:15072099-15073034:-LUADBortezomibEER4.0089e-07-0.2310image
ENSG00000131381.11,RBSNLUADBortezomibEAG6.9303e-06-0.2053image
ENSG00000131381.11,RBSNLUSCAP.24534EAG7.2143e-050.1864image
chr3:15072099-15073034:-LUSCAP.24534EER9.0758e-050.1839image
ENSG00000131381.11,RBSNMESOA.770041EAG7.0776e-03-0.3148image
chr3:15072099-15073034:-MESOA.770041EER3.3250e-03-0.3438image
chr3:15072099-15073034:-OVBexaroteneEER3.0544e-110.4064image
ENSG00000131381.11,RBSNOVAG.014699EAG4.9284e-030.1746image
ENSG00000131381.11,RBSNPAADAZD6244EAG1.3361e-03-0.2571image
chr3:15072099-15073034:-PAADAZD6482EER3.9745e-040.2893image
ENSG00000131381.11,RBSNPCPGGefitinibEAG2.9105e-03-0.2490image
chr3:15072099-15073034:-PCPGAZD6244EER9.0130e-04-0.2775image
chr3:15072099-15073034:-PRADBMS.536924EER9.1828e-12-0.3168image
ENSG00000131381.11,RBSNPRADBMS.536924EAG1.7789e-06-0.2244image
ENSG00000131381.11,RBSNSARCDasatinibEAG7.1208e-07-0.3234image
chr3:15072099-15073034:-SARCBMS.536924EER8.5804e-10-0.3969image
chr3:15072099-15073034:-SKCMAZD6244EER5.5381e-09-0.2765image
ENSG00000131381.11,RBSNSKCMAZD6244EAG3.3227e-08-0.2622image
ENSG00000131381.11,RBSNSTADCCT007093EAG1.6316e-070.2822image
chr3:15072099-15073034:-STADImatinibEER2.8757e-080.3013image
ENSG00000131381.11,RBSNTGCTAZD6482EAG3.8615e-070.4203image
chr3:15072099-15073034:-TGCTAZD6482EER5.7216e-090.4768image
ENSG00000131381.11,RBSNTHCAEmbelinEAG3.4962e-250.4481image
chr3:15072099-15073034:-THCAEmbelinEER1.9558e-260.4590image
chr3:15072099-15073034:-THYMBMS.536924EER3.5072e-05-0.4796image
ENSG00000131381.11,RBSNTHYMBortezomibEAG2.2170e-03-0.3598image
chr3:15072099-15073034:-UCECBAY.61.3606EER1.3478e-020.2241image
ENSG00000131381.11,RBSNUCECJNK.9LEAG2.6158e-040.3174image
chr3:15072099-15073034:-UCSKU.55933EER3.4250e-030.4318image
ENSG00000131381.11,RBSNUCSKU.55933EAG1.6484e-030.4607image
ENSG00000131381.11,RBSNUVMCGP.60474EAG1.5455e-04-0.5195image
chr3:15072099-15073034:-UVMCGP.60474EER1.2404e-04-0.5258image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType