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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: FAM111A (ImmuneEditome ID:63901)

1. Gene summary of enriched editing regions for FAM111A

check button Gene summary
Gene informationGene symbol

FAM111A

Gene ID

63901

GeneSynonymsGCLEB|KCS2
GeneCytomap

11q12.1

GeneTypeprotein-coding
GeneDescriptionserine protease FAM111A|family with sequence similarity 111 member A|protein FAM111A
GeneModificationdate20230415
UniprotIDQ96PZ2;A0A024R4Z3;A0A804HLI8
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr11:59146668-59147484:+ENST00000529358.1ENSG00000166801.14FAM111AncRNA_intronicMER87B,MIRc,L1MC5achr11:59146668-59147484:+.alignment
chr11:59146668-59147484:+ENST00000532790.4ENSG00000166801.14FAM111AncRNA_intronicMER87B,MIRc,L1MC5achr11:59146668-59147484:+.alignment


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2. Tumor-specific enriched editing regions for FAM111A


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000166801.14,FAM111AESCACliEAG9.3611e-035.2829e-03-0.4552image
chr11:59146668-59147484:+ESCACliEER9.3611e-035.2829e-03-0.4552image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
ENSG00000166801.14,FAM111ASTADEAG7.2786e-031.4060e-021.0065e-01image

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3. Enriched editing regions and immune related genes for FAM111A


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for FAM111A


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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5. Enriched editing regions and immune infiltration for FAM111A


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr11:59146668-59147484:+BLCAEERMonocytes1.5426e-02-0.4382image
ENSG00000166801.14,FAM111ABLCAEAGMonocytes1.5426e-02-0.4382image
ENSG00000166801.14,FAM111ABRCAEAGB_cells_naive3.1908e-02-0.1304image
chr11:59146668-59147484:+CESCEERMast_cells_activated1.0255e-02-0.4169image
ENSG00000166801.14,FAM111ACESCEAGMast_cells_activated1.0255e-02-0.4169image
chr11:59146668-59147484:+COADEERNK_cells_resting2.3917e-03-0.4562image
ENSG00000166801.14,FAM111ACOADEAGNK_cells_resting2.3917e-03-0.4562image
chr11:59146668-59147484:+ESCAEERMacrophages_M01.0608e-040.3834image
ENSG00000166801.14,FAM111AESCAEAGMacrophages_M01.0258e-040.3841image
chr11:59146668-59147484:+KIRCEERT_cells_CD83.0458e-030.2813image
ENSG00000166801.14,FAM111AKIRCEAGT_cells_CD83.0458e-030.2813image
chr11:59146668-59147484:+KIRPEERNK_cells_activated3.2646e-02-0.3728image
ENSG00000166801.14,FAM111AKIRPEAGNK_cells_activated3.2646e-02-0.3728image
chr11:59146668-59147484:+LAMLEERB_cells_memory1.7231e-020.2062image
ENSG00000166801.14,FAM111ALAMLEAGB_cells_memory1.4566e-020.2106image
chr11:59146668-59147484:+LUADEERT_cells_gamma_delta1.3959e-02-0.2673image
ENSG00000166801.14,FAM111ALUADEAGT_cells_CD4_memory_resting1.7909e-02-0.2563image
chr11:59146668-59147484:+OVEERT_cells_regulatory_(Tregs)2.6179e-040.6284image
ENSG00000166801.14,FAM111AOVEAGT_cells_regulatory_(Tregs)2.6179e-040.6284image
chr11:59146668-59147484:+STADEEREosinophils3.0205e-030.2463image
ENSG00000166801.14,FAM111ASTADEAGEosinophils3.6270e-030.2409image
chr11:59146668-59147484:+THCAEERDendritic_cells_activated1.8092e-020.2544image
ENSG00000166801.14,FAM111ATHCAEAGDendritic_cells_activated1.8092e-020.2544image


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6. Enriched editing regions and immune gene sets for FAM111A


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr11:59146668-59147484:+BLCAGSVA_HALLMARK_TGF_BETA_SIGNALINGEER8.6722e-03-0.4706image
ENSG00000166801.14,FAM111ABLCAGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG8.6722e-03-0.4706image
chr11:59146668-59147484:+BRCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.5785e-02-0.1471image
ENSG00000166801.14,FAM111ABRCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.0884e-02-0.1545image
chr11:59146668-59147484:+CESCGSVA_HALLMARK_G2M_CHECKPOINTEER1.3842e-02-0.4012image
ENSG00000166801.14,FAM111ACESCGSVA_HALLMARK_G2M_CHECKPOINTEAG1.3842e-02-0.4012image
ENSG00000166801.14,FAM111ACOADGSVA_HALLMARK_NOTCH_SIGNALINGEAG2.6577e-020.3421image
chr11:59146668-59147484:+COADGSVA_HALLMARK_NOTCH_SIGNALINGEER2.6577e-020.3421image
ENSG00000166801.14,FAM111AESCAGSVA_HALLMARK_HYPOXIAEAG4.6424e-040.3487image
chr11:59146668-59147484:+ESCAGSVA_HALLMARK_HYPOXIAEER4.8198e-040.3478image
ENSG00000166801.14,FAM111AGBMGSVA_HALLMARK_APOPTOSISEAG3.6887e-030.5693image
chr11:59146668-59147484:+GBMGSVA_HALLMARK_APOPTOSISEER3.6887e-030.5693image
ENSG00000166801.14,FAM111AKIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.7649e-030.2580image
chr11:59146668-59147484:+KIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER6.7649e-030.2580image
ENSG00000166801.14,FAM111AKIRPGSVA_HALLMARK_E2F_TARGETSEAG2.7360e-030.5048image
chr11:59146668-59147484:+KIRPGSVA_HALLMARK_E2F_TARGETSEER2.7360e-030.5048image
ENSG00000166801.14,FAM111ALAMLGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.0036e-02-0.2217image
chr11:59146668-59147484:+LAMLGSVA_HALLMARK_MITOTIC_SPINDLEEER1.0647e-02-0.2208image
ENSG00000166801.14,FAM111ALUADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.1690e-020.2332image
chr11:59146668-59147484:+LUADGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER7.7307e-030.2887image
chr11:59146668-59147484:+LUSCGSVA_HALLMARK_PROTEIN_SECRETIONEER1.4556e-020.3620image
ENSG00000166801.14,FAM111ALUSCGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.4556e-020.3620image
ENSG00000166801.14,FAM111AOVGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.6376e-02-0.4420image
chr11:59146668-59147484:+OVGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.6376e-02-0.4420image
ENSG00000166801.14,FAM111ASTADGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.9823e-030.2557image
chr11:59146668-59147484:+STADGSVA_HALLMARK_PROTEIN_SECRETIONEER4.0223e-030.2391image
ENSG00000166801.14,FAM111ATHCAGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.4774e-030.3376image
chr11:59146668-59147484:+THCAGSVA_HALLMARK_ANDROGEN_RESPONSEEER1.4774e-030.3376image


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7. Enriched editing regions and drugs for FAM111A


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr11:59146668-59147484:+BLCAMethotrexateEER7.1590e-03-0.4808image
ENSG00000166801.14,FAM111ABLCAMethotrexateEAG7.1590e-03-0.4808image
chr11:59146668-59147484:+BRCAKIN001.135EER5.9329e-030.1674image
ENSG00000166801.14,FAM111ABRCAKIN001.135EAG1.8126e-030.1887image
chr11:59146668-59147484:+CESCBMS.536924EER4.1820e-03-0.4599image
ENSG00000166801.14,FAM111ACESCBMS.536924EAG4.1820e-03-0.4599image
ENSG00000166801.14,FAM111ACOADGNF.2EAG3.3537e-02-0.3287image
chr11:59146668-59147484:+COADGNF.2EER3.3537e-02-0.3287image
ENSG00000166801.14,FAM111AESCAImatinibEAG5.0947e-03-0.2822image
chr11:59146668-59147484:+ESCAImatinibEER5.0212e-03-0.2827image
ENSG00000166801.14,FAM111AGBMDMOGEAG1.5648e-03-0.6096image
chr11:59146668-59147484:+GBMDMOGEER1.5648e-03-0.6096image
ENSG00000166801.14,FAM111AKIRCAP.24534EAG1.5804e-030.2991image
chr11:59146668-59147484:+KIRCAP.24534EER1.5804e-030.2991image
ENSG00000166801.14,FAM111AKIRPCisplatinEAG1.1514e-02-0.4345image
chr11:59146668-59147484:+KIRPCisplatinEER1.1514e-02-0.4345image
ENSG00000166801.14,FAM111ALAMLJNK.9LEAG3.4115e-02-0.1832image
chr11:59146668-59147484:+LAMLGSK.650394EER2.3890e-02-0.1958image
ENSG00000166801.14,FAM111ALUADGW843682XEAG3.5308e-03-0.3131image
chr11:59146668-59147484:+LUADCCT007093EER9.6125e-040.3538image
chr11:59146668-59147484:+LUSCMG.132EER1.1250e-02-0.3745image
ENSG00000166801.14,FAM111ALUSCMG.132EAG1.1250e-02-0.3745image
ENSG00000166801.14,FAM111AOVBortezomibEAG1.8142e-04-0.6406image
chr11:59146668-59147484:+OVBortezomibEER1.8142e-04-0.6406image
ENSG00000166801.14,FAM111ASTADBexaroteneEAG4.5622e-03-0.2351image
chr11:59146668-59147484:+STADBexaroteneEER5.6945e-03-0.2301image
ENSG00000166801.14,FAM111ATHCACEP.701EAG8.6852e-040.3526image
chr11:59146668-59147484:+THCACEP.701EER8.6852e-040.3526image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType