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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: SMG1P5 (ImmuneEditome ID:595101)

1. Gene summary of enriched editing regions for SMG1P5

check button Gene summary
Gene informationGene symbol

SMG1P5

Gene ID

595101

GeneSynonyms-
GeneCytomap

16p11.2

GeneTypepseudo
GeneDescriptionSMG1P5, nonsense mediated mRNA decay associated PI3K related kinase pseudogene 5|smg-1 homolog, phosphatidylinositol 3-kinase-related kinase pseudogene
GeneModificationdate20230329
UniprotID.
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr16:30282487-30284599:-ENST00000529428.4ENSG00000183604.13SMG1P5ncRNA_intronicL1MB8,AluSq2,AluSz,MER58D,Tigger4b,AluSx1,Tigger4achr16:30282487-30284599:-.alignment


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2. Tumor-specific enriched editing regions for SMG1P5


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr16:30282487-30284599:-SARCEER3.9967e-021.6397e-021.4809e+01image
ENSG00000183604.13,SMG1P5SARCEAG3.9967e-021.6397e-021.4809e+01image

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3. Enriched editing regions and immune related genes for SMG1P5


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for SMG1P5


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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5. Enriched editing regions and immune infiltration for SMG1P5


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr16:30282487-30284599:-ACCEERMacrophages_M01.7783e-020.3776image
ENSG00000183604.13,SMG1P5ACCEAGMacrophages_M01.7783e-020.3776image
ENSG00000183604.13,SMG1P5BLCAEAGNK_cells_resting3.5670e-02-0.1594image
chr16:30282487-30284599:-BRCAEERMacrophages_M23.8759e-03-0.1347image
ENSG00000183604.13,SMG1P5BRCAEAGMacrophages_M23.9921e-03-0.1341image
ENSG00000183604.13,SMG1P5CESCEAGT_cells_CD4_memory_activated4.6240e-02-0.1779image
chr16:30282487-30284599:-COADEERT_cells_follicular_helper2.4505e-02-0.2134image
ENSG00000183604.13,SMG1P5COADEAGT_cells_follicular_helper1.4642e-02-0.2301image
chr16:30282487-30284599:-DLBCEERT_cells_regulatory_(Tregs)3.6960e-03-0.5803image
ENSG00000183604.13,SMG1P5DLBCEAGT_cells_regulatory_(Tregs)3.6960e-03-0.5803image
chr16:30282487-30284599:-GBMEERMonocytes3.9890e-020.2147image
ENSG00000183604.13,SMG1P5GBMEAGMonocytes3.9890e-020.2147image
chr16:30282487-30284599:-HNSCEERB_cells_naive4.7847e-03-0.2613image
ENSG00000183604.13,SMG1P5HNSCEAGB_cells_naive4.7847e-03-0.2613image
chr16:30282487-30284599:-KICHEERT_cells_CD81.7722e-020.4043image
ENSG00000183604.13,SMG1P5KICHEAGT_cells_CD81.7722e-020.4043image
chr16:30282487-30284599:-KIRPEERDendritic_cells_resting2.4204e-020.2066image
ENSG00000183604.13,SMG1P5KIRPEAGDendritic_cells_resting2.4204e-020.2066image
ENSG00000183604.13,SMG1P5LIHCEAGNK_cells_resting5.8944e-03-0.3459image
chr16:30282487-30284599:-LUADEERNeutrophils2.6970e-02-0.2037image
ENSG00000183604.13,SMG1P5LUADEAGNeutrophils2.6979e-02-0.2036image
chr16:30282487-30284599:-LUSCEERMacrophages_M23.0342e-02-0.1781image
ENSG00000183604.13,SMG1P5LUSCEAGMacrophages_M23.0342e-02-0.1781image
ENSG00000183604.13,SMG1P5PAADEAGB_cells_naive2.1710e-020.3763image
chr16:30282487-30284599:-PRADEERMast_cells_resting1.3286e-020.2245image
ENSG00000183604.13,SMG1P5PRADEAGMast_cells_resting1.3493e-020.2240image
chr16:30282487-30284599:-READEERB_cells_naive3.7597e-030.4771image
ENSG00000183604.13,SMG1P5READEAGB_cells_naive3.7597e-030.4771image
chr16:30282487-30284599:-SARCEERMast_cells_resting3.3997e-020.2359image
ENSG00000183604.13,SMG1P5SARCEAGMast_cells_resting3.3997e-020.2359image
chr16:30282487-30284599:-SKCMEERB_cells_memory2.2422e-02-0.1876image
ENSG00000183604.13,SMG1P5SKCMEAGB_cells_memory2.2422e-02-0.1876image
ENSG00000183604.13,SMG1P5STADEAGT_cells_CD4_memory_activated2.2904e-020.1577image
chr16:30282487-30284599:-TGCTEERMacrophages_M24.6972e-02-0.2575image
ENSG00000183604.13,SMG1P5TGCTEAGMacrophages_M24.6972e-02-0.2575image
chr16:30282487-30284599:-THCAEERDendritic_cells_resting3.4935e-020.1433image
ENSG00000183604.13,SMG1P5THCAEAGDendritic_cells_resting3.4935e-020.1433image
chr16:30282487-30284599:-THYMEERMacrophages_M01.2287e-040.4490image
ENSG00000183604.13,SMG1P5THYMEAGMacrophages_M01.2287e-040.4490image
chr16:30282487-30284599:-UCECEERT_cells_regulatory_(Tregs)2.3877e-04-0.3545image
ENSG00000183604.13,SMG1P5UCECEAGT_cells_regulatory_(Tregs)6.0797e-04-0.3306image
ENSG00000183604.13,SMG1P5UCSEAGEosinophils3.0459e-020.3892image
ENSG00000183604.13,SMG1P5UVMEAGT_cells_CD4_memory_activated2.9597e-02-0.4866image


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6. Enriched editing regions and immune gene sets for SMG1P5


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr16:30282487-30284599:-ACCGSVA_HALLMARK_PROTEIN_SECRETIONEER4.6986e-02-0.3201image
ENSG00000183604.13,SMG1P5ACCGSVA_HALLMARK_PROTEIN_SECRETIONEAG4.6986e-02-0.3201image
ENSG00000183604.13,SMG1P5BLCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.1607e-020.1741image
chr16:30282487-30284599:-BLCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.6846e-020.1820image
ENSG00000183604.13,SMG1P5BRCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG5.7944e-06-0.2098image
chr16:30282487-30284599:-BRCAGSVA_HALLMARK_MITOTIC_SPINDLEEER5.4293e-06-0.2107image
ENSG00000183604.13,SMG1P5CESCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG1.9010e-020.2087image
chr16:30282487-30284599:-COADGSVA_HALLMARK_BILE_ACID_METABOLISMEER4.5955e-030.2671image
ENSG00000183604.13,SMG1P5COADGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.0745e-020.2402image
chr16:30282487-30284599:-DLBCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER7.3250e-030.5437image
ENSG00000183604.13,SMG1P5DLBCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG7.3250e-030.5437image
ENSG00000183604.13,SMG1P5ESCAGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.5600e-020.2100image
chr16:30282487-30284599:-ESCAGSVA_HALLMARK_HEME_METABOLISMEER2.0221e-020.2202image
ENSG00000183604.13,SMG1P5GBMGSVA_HALLMARK_APICAL_JUNCTIONEAG2.4346e-030.3124image
chr16:30282487-30284599:-GBMGSVA_HALLMARK_APICAL_JUNCTIONEER2.4346e-030.3124image
ENSG00000183604.13,SMG1P5HNSCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.3727e-02-0.2292image
chr16:30282487-30284599:-HNSCGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.3727e-02-0.2292image
ENSG00000183604.13,SMG1P5KIRCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG4.1695e-02-0.1894image
chr16:30282487-30284599:-KIRCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER4.3827e-02-0.1883image
ENSG00000183604.13,SMG1P5KIRPGSVA_HALLMARK_NOTCH_SIGNALINGEAG1.2111e-020.2293image
chr16:30282487-30284599:-KIRPGSVA_HALLMARK_NOTCH_SIGNALINGEER1.2111e-020.2293image
ENSG00000183604.13,SMG1P5LAMLGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG3.5656e-020.3251image
ENSG00000183604.13,SMG1P5LGGGSVA_HALLMARK_PEROXISOMEEAG3.2370e-03-0.1813image
chr16:30282487-30284599:-LGGGSVA_HALLMARK_PEROXISOMEEER3.2370e-03-0.1813image
chr16:30282487-30284599:-LUSCGSVA_HALLMARK_PANCREAS_BETA_CELLSEER4.4997e-03-0.2323image
ENSG00000183604.13,SMG1P5LUSCGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG4.4997e-03-0.2323image
ENSG00000183604.13,SMG1P5PAADGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG1.4076e-02-0.4004image
ENSG00000183604.13,SMG1P5PCPGGSVA_HALLMARK_COAGULATIONEAG1.0706e-020.2555image
chr16:30282487-30284599:-PCPGGSVA_HALLMARK_COAGULATIONEER1.0706e-020.2555image
ENSG00000183604.13,SMG1P5PRADGSVA_HALLMARK_ANGIOGENESISEAG1.6779e-030.2827image
chr16:30282487-30284599:-PRADGSVA_HALLMARK_ANGIOGENESISEER1.6624e-030.2830image
chr16:30282487-30284599:-READGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER1.8930e-020.3948image
ENSG00000183604.13,SMG1P5READGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG1.8930e-020.3948image
chr16:30282487-30284599:-SARCGSVA_HALLMARK_BILE_ACID_METABOLISMEER4.3196e-02-0.2252image
ENSG00000183604.13,SMG1P5SARCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG4.3196e-02-0.2252image
chr16:30282487-30284599:-SKCMGSVA_HALLMARK_TGF_BETA_SIGNALINGEER5.1800e-03-0.2287image
ENSG00000183604.13,SMG1P5SKCMGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG5.1800e-03-0.2287image
ENSG00000183604.13,SMG1P5STADGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG1.6401e-040.2584image
chr16:30282487-30284599:-STADGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER1.5612e-040.2599image
ENSG00000183604.13,SMG1P5UCECGSVA_HALLMARK_HEME_METABOLISMEAG4.3392e-020.1985image
ENSG00000183604.13,SMG1P5UCSGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG6.3901e-03-0.4791image
ENSG00000183604.13,SMG1P5UVMGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG3.9303e-02-0.4640image


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7. Enriched editing regions and drugs for SMG1P5


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr16:30282487-30284599:-ACCFTI.277EER1.0403e-020.4057image
ENSG00000183604.13,SMG1P5ACCFTI.277EAG1.0403e-020.4057image
ENSG00000183604.13,SMG1P5BLCAGSK.650394EAG2.3249e-020.1720image
chr16:30282487-30284599:-BLCAGSK.650394EER1.2244e-020.1906image
ENSG00000183604.13,SMG1P5BRCAGSK269962AEAG4.7780e-03-0.1321image
chr16:30282487-30284599:-BRCAGSK269962AEER6.0413e-03-0.1287image
ENSG00000183604.13,SMG1P5CESCBI.2536EAG2.5948e-020.1984image
ENSG00000183604.13,SMG1P5DLBCLenalidomideEAG1.5201e-020.4996image
chr16:30282487-30284599:-DLBCLenalidomideEER1.5201e-020.4996image
chr16:30282487-30284599:-ESCAImatinibEER3.4918e-02-0.2004image
ENSG00000183604.13,SMG1P5GBMGW.441756EAG2.9913e-050.4206image
chr16:30282487-30284599:-GBMGW.441756EER2.9913e-050.4206image
ENSG00000183604.13,SMG1P5HNSCCEP.701EAG3.4719e-03-0.2715image
chr16:30282487-30284599:-HNSCCEP.701EER3.4719e-03-0.2715image
ENSG00000183604.13,SMG1P5KICHMetforminEAG9.9992e-04-0.5392image
chr16:30282487-30284599:-KICHMetforminEER9.9992e-04-0.5392image
chr16:30282487-30284599:-KIRCBryostatin.1EER4.5463e-05-0.3707image
ENSG00000183604.13,SMG1P5KIRCBryostatin.1EAG4.9355e-05-0.3675image
chr16:30282487-30284599:-KIRPCyclopamineEER5.4394e-030.2533image
ENSG00000183604.13,SMG1P5KIRPCyclopamineEAG5.4394e-030.2533image
ENSG00000183604.13,SMG1P5LAMLImatinibEAG1.0638e-020.3902image
chr16:30282487-30284599:-LGGBIBW2992EER3.2375e-02-0.1322image
ENSG00000183604.13,SMG1P5LGGBIBW2992EAG3.2375e-02-0.1322image
ENSG00000183604.13,SMG1P5LIHCDocetaxelEAG1.1517e-020.3189image
ENSG00000183604.13,SMG1P5LUADMethotrexateEAG1.5305e-02-0.2228image
chr16:30282487-30284599:-LUADMethotrexateEER1.5312e-02-0.2228image
ENSG00000183604.13,SMG1P5LUSCGemcitabineEAG1.2228e-030.2633image
chr16:30282487-30284599:-LUSCGemcitabineEER1.2228e-030.2633image
chr16:30282487-30284599:-OVBI.D1870EER9.1542e-03-0.1994image
ENSG00000183604.13,SMG1P5OVBI.D1870EAG1.1148e-02-0.1942image
ENSG00000183604.13,SMG1P5PAADABT.888EAG8.3614e-03-0.4329image
ENSG00000183604.13,SMG1P5PCPGDasatinibEAG2.9686e-04-0.3579image
chr16:30282487-30284599:-PCPGDasatinibEER2.9686e-04-0.3579image
ENSG00000183604.13,SMG1P5PRADIPA.3EAG1.3672e-020.2236image
chr16:30282487-30284599:-PRADIPA.3EER1.3373e-020.2243image
chr16:30282487-30284599:-READGNF.2EER2.2200e-020.3855image
ENSG00000183604.13,SMG1P5READGNF.2EAG2.2200e-020.3855image
chr16:30282487-30284599:-SARCCI.1040EER2.9900e-020.2414image
ENSG00000183604.13,SMG1P5SARCCI.1040EAG2.9900e-020.2414image
chr16:30282487-30284599:-SKCMJNJ.26854165EER4.7840e-02-0.1630image
ENSG00000183604.13,SMG1P5SKCMJNJ.26854165EAG4.7840e-02-0.1630image
ENSG00000183604.13,SMG1P5STADCCT018159EAG1.8355e-02-0.1634image
chr16:30282487-30284599:-STADKU.55933EER9.6790e-03-0.1794image
ENSG00000183604.13,SMG1P5TGCTEHT.1864EAG4.1647e-02-0.2639image
chr16:30282487-30284599:-TGCTEHT.1864EER4.1647e-02-0.2639image
chr16:30282487-30284599:-THCABX.795EER7.5212e-030.1810image
ENSG00000183604.13,SMG1P5THCABX.795EAG7.5212e-030.1810image
ENSG00000183604.13,SMG1P5THYMBIRB.0796EAG1.9584e-020.2825image
chr16:30282487-30284599:-THYMBIRB.0796EER1.9584e-020.2825image
chr16:30282487-30284599:-UCECJNK.Inhibitor.VIIIEER3.1561e-03-0.2882image
ENSG00000183604.13,SMG1P5UCECJNK.Inhibitor.VIIIEAG8.0181e-03-0.2587image
ENSG00000183604.13,SMG1P5UCSMidostaurinEAG2.4899e-02-0.4022image
ENSG00000183604.13,SMG1P5UVMAZ628EAG1.3444e-02-0.5426image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType