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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: OVOL2 (ImmuneEditome ID:58495)

1. Gene summary of enriched editing regions for OVOL2

check button Gene summary
Gene informationGene symbol

OVOL2

Gene ID

58495

GeneSynonymsCHED|CHED1|CHED2|EUROIMAGE566589|PPCD1|ZNF339
GeneCytomap

20p11.23

GeneTypeprotein-coding
GeneDescriptiontranscription factor Ovo-like 2|corneal endothelial dystrophy 1 (autosomal dominant)|zinc finger protein 339
GeneModificationdate20230329
UniprotIDQ9BRP0
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr20:17962284-17962524:-ENST00000486776.4ENSG00000125850.9OVOL2ncRNA_intronicAluSgchr20:17962284-17962524:-.alignment
chr20:18006465-18007311:-ENST00000486776.4ENSG00000125850.9OVOL2ncRNA_intronicL2a,AluSz,FLAM_C,AluSx1chr20:18006465-18007311:-.alignment
chr20:18013066-18013682:-ENST00000486776.4ENSG00000125850.9OVOL2ncRNA_intronicMLT1G3,AluJr,AluSz6chr20:18013066-18013682:-.alignment
chr20:18016689-18017605:-ENST00000486776.4ENSG00000125850.9OVOL2ncRNA_intronicAluSz,L1MC5a,MER2,L1MC,L1ME4b,AluSxchr20:18016689-18017605:-.alignment
chr20:18041953-18042135:-ENST00000462208.1ENSG00000125850.9OVOL2ncRNA_intronicAluSqchr20:18041953-18042135:-.alignment
chr20:18041953-18042135:-ENST00000483661.4ENSG00000125850.9OVOL2ncRNA_intronicAluSqchr20:18041953-18042135:-.alignment
chr20:18041953-18042135:-ENST00000486776.4ENSG00000125850.9OVOL2ncRNA_intronicAluSqchr20:18041953-18042135:-.alignment
chr20:18041953-18042135:-ENST00000494030.1ENSG00000125850.9OVOL2ncRNA_intronicAluSqchr20:18041953-18042135:-.alignment


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2. Tumor-specific enriched editing regions for OVOL2


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for OVOL2


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check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for OVOL2


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr20:17962284-17962524:-
ESCAEERESENSG00000158636.12chr1176458182:76458358:76459935:76460085:76463820:764640800.33457.8301e-031.7648e-080.5160imageNCELF2;CSTF2T;EIF4G2;IGF2BP1;IGF2BP2;MSI1;NOP56;NOP58;PTBP1;RBFOX2;SRSF7;TARDBP;U2AF2NAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
ENSG00000125850.9,OVOL2
ESCAEAGA3ENSG00000123136.10chr1914410988:14411136:14409741:14410334:14409741:14410605-0.37111.3281e-023.1483e-07-0.4056imageNDDX54;DGCR8;DHX9;EWSR1;FBL;FUS;HNRNPC;NOP56;NOP58;RBFOX2;TAF15;TARDBP;UPF1NAMast_cells_activatedGSVA_HALLMARK_MYC_TARGETS_V2

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5. Enriched editing regions and immune infiltration for OVOL2


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000125850.9,OVOL2BLCAEAGB_cells_memory1.5137e-020.3203image
ENSG00000125850.9,OVOL2CESCEAGT_cells_CD82.8644e-020.3097image
ENSG00000125850.9,OVOL2COADEAGDendritic_cells_activated1.3825e-040.4018image
chr20:17962284-17962524:-ESCAEERT_cells_follicular_helper7.7269e-03-0.2235image
ENSG00000125850.9,OVOL2ESCAEAGMast_cells_resting1.2669e-020.2045image
ENSG00000125850.9,OVOL2KIRPEAGMacrophages_M05.8378e-030.5352image
ENSG00000125850.9,OVOL2LUADEAGNK_cells_activated1.3226e-030.3713image
chr20:18006465-18007311:-OVEERT_cells_CD82.2856e-02-0.2592image
ENSG00000125850.9,OVOL2OVEAGNeutrophils8.0230e-03-0.2164image
ENSG00000125850.9,OVOL2PRADEAGMast_cells_resting6.5076e-030.3915image
ENSG00000125850.9,OVOL2READEAGT_cells_CD4_memory_activated1.5060e-02-0.4077image
ENSG00000125850.9,OVOL2SKCMEAGMacrophages_M02.6115e-03-0.2869image
chr20:18006465-18007311:-STADEERT_cells_follicular_helper1.1563e-020.2921image
ENSG00000125850.9,OVOL2STADEAGMast_cells_resting8.0391e-030.1631image
ENSG00000125850.9,OVOL2TGCTEAGT_cells_CD4_memory_activated1.8870e-020.3157image


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6. Enriched editing regions and immune gene sets for OVOL2


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000125850.9,OVOL2KIRPEAG2.0307e-04-0.67683.3721e-03-0.56323.6653e-04-0.65642.2182e-02-0.4553image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000125850.9,OVOL2BLCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG8.1383e-03-0.3472image
chr20:17962284-17962524:-BRCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER8.3142e-03-0.4887image
ENSG00000125850.9,OVOL2BRCAGSVA_HALLMARK_MYOGENESISEAG2.0968e-030.1824image
ENSG00000125850.9,OVOL2CESCGSVA_HALLMARK_UV_RESPONSE_DNEAG2.4504e-02-0.3178image
chr20:18006465-18007311:-CESCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER2.0392e-040.6192image
ENSG00000125850.9,OVOL2COADGSVA_HALLMARK_PEROXISOMEEAG6.4658e-04-0.3627image
chr20:17962284-17962524:-ESCAGSVA_HALLMARK_MYC_TARGETS_V2EER1.9471e-02-0.1966image
ENSG00000125850.9,OVOL2ESCAGSVA_HALLMARK_MYC_TARGETS_V2EAG3.5551e-03-0.2382image
ENSG00000125850.9,OVOL2KIRPGSVA_HALLMARK_MYC_TARGETS_V1EAG1.2583e-05-0.7556image
chr20:17962284-17962524:-OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER5.6905e-030.4057image
ENSG00000125850.9,OVOL2OVGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG4.8763e-04-0.2822image
chr20:18006465-18007311:-OVGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER3.5268e-02-0.2403image
ENSG00000125850.9,OVOL2PRADGSVA_HALLMARK_G2M_CHECKPOINTEAG2.1003e-03-0.4376image
ENSG00000125850.9,OVOL2READGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG2.0505e-02-0.3901image
ENSG00000125850.9,OVOL2SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG7.9100e-040.3182image
chr20:18006465-18007311:-STADGSVA_HALLMARK_HEME_METABOLISMEER3.3625e-020.2473image
chr20:18013066-18013682:-STADGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER1.9069e-030.5355image
ENSG00000125850.9,OVOL2STADGSVA_HALLMARK_MYC_TARGETS_V2EAG3.7280e-06-0.2808image
ENSG00000125850.9,OVOL2TGCTGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.6019e-020.3234image


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7. Enriched editing regions and drugs for OVOL2


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000125850.9,OVOL2BLCABAY.61.3606EAG7.9146e-040.4320image
ENSG00000125850.9,OVOL2BRCABMS.536924EAG1.4949e-04-0.2243image
ENSG00000125850.9,OVOL2CESCCyclopamineEAG1.6213e-03-0.4344image
chr20:18006465-18007311:-CESCCyclopamineEER4.2749e-03-0.4989image
ENSG00000125850.9,OVOL2COADAG.014699EAG4.1992e-03-0.3075image
chr20:17962284-17962524:-ESCALFM.A13EER3.2544e-03-0.2462image
ENSG00000125850.9,OVOL2ESCAAS601245EAG2.7153e-03-0.2448image
ENSG00000125850.9,OVOL2KIRPEpothilone.BEAG1.7323e-030.5943image
ENSG00000125850.9,OVOL2LUADCisplatinEAG4.1523e-030.3339image
ENSG00000125850.9,OVOL2LUSCAMG.706EAG7.9837e-040.2700image
chr20:17962284-17962524:-OVABT.263EER1.2637e-030.4657image
ENSG00000125850.9,OVOL2OVElesclomolEAG6.7548e-03-0.2210image
chr20:18006465-18007311:-OVDoxorubicinEER2.0908e-02-0.2629image
ENSG00000125850.9,OVOL2PRADABT.263EAG4.3847e-020.2954image
ENSG00000125850.9,OVOL2READCyclopamineEAG9.9889e-03-0.4297image
ENSG00000125850.9,OVOL2SKCMBMS.536924EAG3.1854e-03-0.2813image
chr20:18013066-18013682:-STADBicalutamideEER4.5204e-02-0.3623image
ENSG00000125850.9,OVOL2STADLFM.A13EAG5.5401e-05-0.2459image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType