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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: INIP (ImmuneEditome ID:58493)

1. Gene summary of enriched editing regions for INIP

check button Gene summary
Gene informationGene symbol

INIP

Gene ID

58493

GeneSynonymsC9orf80|HSPC043|MISE|SOSSC|SSBIP1|hSSBIP1
GeneCytomap

9q32

GeneTypeprotein-coding
GeneDescriptionSOSS complex subunit C|SSB-interacting protein 1|hSSB-interacting protein 1|minute INTS3/hSSB-associated element|sensor of single-strand DNA complex subunit C|sensor of ssDNA subunit C|single-stranded DNA-binding protein-interacting protein 1
GeneModificationdate20230329
UniprotIDQ9NRY2;Q5VWJ6;X6R8P6
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr9:112684242-112685344:-ENST00000374242.7ENSG00000148153.12INIPUTR3L2a,MER112,AluJb,AluJrchr9:112684242-112685344:-.alignment
chr9:112686544-112686779:-ENST00000374242.7ENSG00000148153.12INIPUTR3AluSzchr9:112686544-112686779:-.alignment


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2. Tumor-specific enriched editing regions for INIP


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr9:112684242-112685344:-BRCAEER1.2561e-02image
ENSG00000148153.12,INIPBRCAEAG6.1542e-03image
chr9:112684242-112685344:-COADEER5.1043e-20image
ENSG00000148153.12,INIPCOADEAG2.6053e-20image
chr9:112684242-112685344:-HNSCEER1.3887e-04image
ENSG00000148153.12,INIPHNSCEAG5.3441e-04image
chr9:112684242-112685344:-KIRCEER1.6014e-10image
ENSG00000148153.12,INIPKIRCEAG6.4301e-11image
chr9:112684242-112685344:-KIRPEER1.2230e-02image
ENSG00000148153.12,INIPKIRPEAG1.3626e-03image
chr9:112684242-112685344:-LUADEER3.8151e-02image
chr9:112684242-112685344:-LUSCEER2.7081e-07image
ENSG00000148153.12,INIPLUSCEAG5.1520e-08image
chr9:112684242-112685344:-PRADEER5.5843e-03image
ENSG00000148153.12,INIPPRADEAG1.4838e-03image
chr9:112684242-112685344:-THCAEER2.5172e-04image
ENSG00000148153.12,INIPTHCAEAG2.5510e-04image
chr9:112684242-112685344:-UCECEER1.6909e-04image
ENSG00000148153.12,INIPUCECEAG1.8645e-04image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000148153.12,INIPCESCCliEAG1.1887e-021.5547e-03-0.1825image
chr9:112684242-112685344:-CESCCliEER8.6115e-039.9228e-04-0.1898image
ENSG00000148153.12,INIPKIRCPathEAG2.3486e-022.2951e-030.1323image
chr9:112684242-112685344:-KIRCPathEER3.7694e-024.4819e-030.1235image
chr9:112684242-112685344:-THCAPathEER2.6975e-022.2436e-020.1018image
ENSG00000148153.12,INIPTHCAPathEAG1.4318e-021.8366e-020.1051image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
ENSG00000148153.12,INIPCOADEAG4.6063e-024.6122e-033.5326e+01image

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3. Enriched editing regions and immune related genes for INIP


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr9:112684242-112685344:-COADEERENSG00000252496,RNA5SP330.14946.6425e-035.3030e-510.7539imageNNNAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr9:112684242-112685344:-COADEERENSG00000278099,U10.13021.1426e-022.2152e-370.6749imageNNNADendritic_cells_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr9:112684242-112685344:-COADEERENSG00000277918,U10.13011.1764e-022.3389e-380.6816imageNNNAMast_cells_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr9:112684242-112685344:-COADEERENSG00000201315,RN7SKP2270.10401.1918e-025.3417e-140.4360imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_UP
chr9:112684242-112685344:-COADEERENSG00000206588,RNU1-28P0.11851.3259e-025.1747e-390.6859imageNNNADendritic_cells_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr9:112684242-112685344:-COADEERENSG00000252274,SCARNA240.19781.6722e-021.3152e-240.5686imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_P53_PATHWAY
chr9:112684242-112685344:-COADEERENSG00000252985,SNORD1160.14481.9952e-022.6833e-150.4556imageNNNAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr9:112684242-112685344:-COADEERENSG00000201998,SNORA230.19142.1053e-021.2619e-120.4136imageNNNAEosinophilsGSVA_HALLMARK_P53_PATHWAY
chr9:112684242-112685344:-COADEERENSG00000257979,SNRPGP180.12242.2133e-025.9791e-410.6983imageNNNAEosinophilsGSVA_HALLMARK_P53_PATHWAY
chr9:112684242-112685344:-COADEERENSG00000253043,RNU7-181P0.13282.4698e-023.5752e-280.6026imageNNNAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr9:112686544-112686779:-STADEERENSG00000231878,SNRPFP10.21683.9862e-036.9720e-140.4083imageNNNAT_cells_CD8GSVA_HALLMARK_UV_RESPONSE_DN
chr9:112686544-112686779:-STADEERENSG00000229119,CTB-63M22.10.19909.8915e-031.7732e-140.4171imageNNNANK_cells_activatedGSVA_HALLMARK_UV_RESPONSE_DN
chr9:112686544-112686779:-STADEERENSG00000230191,RP4-725G10.30.16743.6006e-025.1079e-140.4103imageNNNAT_cells_CD8GSVA_HALLMARK_BILE_ACID_METABOLISM

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4. Enriched editing regions and immune related splicing for INIP


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000148153.12,INIP
BLCAEAGIRENSG00000229117.4chr1256116780:56117211:56117512:56117645-0.04849.5494e-037.0797e-18-0.4108imageNADAR;AIFM1;AUH;CAPRIN1;CBX7;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;EIF4A3;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LIN28;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;SAFB2;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZNF184NAB_cells_naiveGSVA_HALLMARK_PANCREAS_BETA_CELLS
chr9:112684242-112685344:-
BLCAEERIRENSG00000229117.4chr1256116780:56117211:56117512:56117645-0.04751.0059e-021.5146e-17-0.4070imageNFBL;IGF2BP2;TARDBP;TROVE2;UPF1NAB_cells_naiveGSVA_HALLMARK_PANCREAS_BETA_CELLS
chr9:112684242-112685344:-
COADEERA5ENSG00000070756.9chr8100717816:100717888:100718230:100718280:100718182:100718280-0.23332.3424e-025.4747e-12-0.4027imageNACIN1;FBL;IGF2BP2;TARDBP;TROVE2;UPF1NAMacrophages_M0GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
ENSG00000148153.12,INIP
COADEAGA3ENSG00000137166.10chr641589770:41589854:41589998:41590170:41589962:41590170-0.21774.8598e-026.8544e-12-0.4038imageNADAR;AIFM1;AUH;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;SAFB2;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NADendritic_cells_activatedGSVA_HALLMARK_E2F_TARGETS
ENSG00000148153.12,INIP
COADEAGA5ENSG00000070756.9chr8100717816:100717888:100718230:100718280:100718182:100718280-0.26057.1831e-037.7746e-15-0.4480imageNACIN1;ADAR;AIFM1;AUH;CAPRIN1;CBX7;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;SAFB2;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NAMacrophages_M0GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr9:112684242-112685344:-
COADEERMEXENSG00000125691.8chr1738852603:38852732:38853021:38853051:38853055:38853105:38853697:388537220.22214.1230e-023.1175e-220.5435imageNACIN1;FBL;IGF2BP2;TARDBP;TROVE2;UPF1NAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000148153.12,INIP
COADEAGIRENSG00000006114.11chr1737584321:37584759:37585324:375854130.19754.9351e-022.4477e-280.6356imageNNNADendritic_cells_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000148153.12,INIP
COADEAGIRENSG00000197681.8chr1738195879:38195940:38196366:381964710.21614.9879e-021.4507e-430.7151imageNACIN1;ADAR;AIFM1;AUH;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;EIF4A3;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LIN28;LIN28B;LSM11;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;SAFB2;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;ZNF184NAMast_cells_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr9:112684242-112685344:-
COADEERMEXENSG00000142541.12chr1949487633:49487644:49489849:49490280:49490778:49491099:49491424:49491547-0.22284.2688e-023.0040e-21-0.5325imageNACIN1;FBL;IGF2BP2;TARDBP;TROVE2;UPF1NAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000148153.12,INIP
COADEAGMEXENSG00000168374.6chr357571404:57572298:57575547:57575673:57584383:57584464:57597073:575971980.22534.3432e-025.8754e-170.4783imageNACIN1;ADAR;AIFM1;AUH;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;SAFB2;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NADendritic_cells_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY

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5. Enriched editing regions and immune infiltration for INIP


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr9:112684242-112685344:-BRCAEERB_cells_naive1.0077e-03-0.0999image
ENSG00000148153.12,INIPBRCAEAGB_cells_naive1.1411e-03-0.0988image
chr9:112684242-112685344:-CESCEERMast_cells_activated1.0846e-03-0.1868image
ENSG00000148153.12,INIPCESCEAGMast_cells_activated1.7512e-03-0.1791image
chr9:112684242-112685344:-CHOLEERT_cells_CD4_memory_resting3.5747e-030.4793image
ENSG00000148153.12,INIPCHOLEAGT_cells_CD4_memory_resting3.9965e-030.4743image
chr9:112684242-112685344:-COADEERDendritic_cells_activated1.0762e-030.1976image
ENSG00000148153.12,INIPCOADEAGDendritic_cells_activated1.6106e-030.1904image
chr9:112684242-112685344:-DLBCEERNK_cells_activated2.9683e-020.3141image
ENSG00000148153.12,INIPDLBCEAGNK_cells_activated2.3681e-020.3261image
chr9:112684242-112685344:-ESCAEERMacrophages_M22.8769e-050.3252image
ENSG00000148153.12,INIPESCAEAGMacrophages_M21.0269e-030.2572image
chr9:112684242-112685344:-GBMEERMacrophages_M16.7225e-030.2096image
ENSG00000148153.12,INIPGBMEAGMacrophages_M13.8677e-030.2231image
chr9:112684242-112685344:-HNSCEERNK_cells_activated5.9904e-030.1228image
ENSG00000148153.12,INIPHNSCEAGNK_cells_activated1.5852e-020.1078image
chr9:112684242-112685344:-KIRCEERMacrophages_M22.6897e-03-0.1533image
ENSG00000148153.12,INIPKIRCEAGMacrophages_M23.6680e-04-0.1814image
chr9:112684242-112685344:-KIRPEERT_cells_regulatory_(Tregs)1.7382e-020.1401image
ENSG00000148153.12,INIPKIRPEAGDendritic_cells_activated1.2110e-020.1477image
chr9:112684242-112685344:-LAMLEERNK_cells_resting2.3593e-040.3233image
ENSG00000148153.12,INIPLAMLEAGNK_cells_resting2.8955e-040.3164image
chr9:112684242-112685344:-LGGEERT_cells_regulatory_(Tregs)1.4745e-020.1060image
ENSG00000148153.12,INIPLGGEAGT_cells_regulatory_(Tregs)6.0120e-030.1193image
chr9:112684242-112685344:-LIHCEERB_cells_memory2.0028e-02-0.1214image
ENSG00000148153.12,INIPLIHCEAGB_cells_memory2.1693e-02-0.1198image
chr9:112684242-112685344:-LUADEERT_cells_gamma_delta1.1058e-050.1934image
ENSG00000148153.12,INIPLUADEAGT_cells_gamma_delta1.0408e-050.1938image
chr9:112684242-112685344:-LUSCEERPlasma_cells1.7032e-020.1070image
ENSG00000148153.12,INIPLUSCEAGPlasma_cells9.0792e-030.1169image
chr9:112684242-112685344:-MESOEERT_cells_regulatory_(Tregs)9.0877e-03-0.2864image
ENSG00000148153.12,INIPMESOEAGT_cells_regulatory_(Tregs)8.5942e-03-0.2884image
chr9:112684242-112685344:-OVEERT_cells_CD81.5611e-020.1416image
ENSG00000148153.12,INIPOVEAGT_cells_CD86.3133e-030.1598image
chr9:112684242-112685344:-PAADEERMacrophages_M03.2812e-020.1610image
ENSG00000148153.12,INIPPAADEAGMacrophages_M01.8634e-020.1772image
chr9:112684242-112685344:-PCPGEERMonocytes3.8178e-02-0.1538image
ENSG00000148153.12,INIPPCPGEAGMonocytes3.0243e-02-0.1607image
chr9:112684242-112685344:-PRADEERNK_cells_activated7.6060e-030.1195image
ENSG00000148153.12,INIPPRADEAGNK_cells_activated5.3220e-030.1247image
chr9:112684242-112685344:-READEERNK_cells_activated3.2665e-020.2206image
ENSG00000148153.12,INIPREADEAGNK_cells_activated2.0745e-020.2383image
chr9:112684242-112685344:-SKCMEERMacrophages_M13.9660e-03-0.1339image
ENSG00000148153.12,INIPSKCMEAGMacrophages_M12.2612e-03-0.1419image
chr9:112684242-112685344:-STADEERT_cells_gamma_delta2.1264e-040.1930image
chr9:112686544-112686779:-STADEERT_cells_CD82.8751e-020.1242image
ENSG00000148153.12,INIPSTADEAGT_cells_gamma_delta4.4618e-040.1829image
chr9:112684242-112685344:-TGCTEERMacrophages_M26.7306e-03-0.2196image
ENSG00000148153.12,INIPTGCTEAGMacrophages_M24.3784e-03-0.2307image
chr9:112684242-112685344:-THCAEERT_cells_CD4_memory_activated1.2886e-020.1107image
ENSG00000148153.12,INIPTHCAEAGT_cells_CD4_memory_activated8.7272e-030.1167image
chr9:112684242-112685344:-THYMEERT_cells_gamma_delta2.0241e-020.2154image
ENSG00000148153.12,INIPTHYMEAGT_cells_gamma_delta1.5429e-020.2244image
chr9:112684242-112685344:-UVMEERNK_cells_resting3.7587e-02-0.2626image
ENSG00000148153.12,INIPUVMEAGNK_cells_resting3.4857e-02-0.2663image


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6. Enriched editing regions and immune gene sets for INIP


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr9:112684242-112685344:-STADEER4.5641e-02image4.0699e-030.1502image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr9:112684242-112685344:-COADEER8.8221e-04-0.20093.6622e-02-0.12708.2941e-05-0.23681.6339e-02-0.1458image
ENSG00000148153.12,INIPCOADEAG4.7756e-04-0.21044.3196e-02-0.12273.8498e-05-0.24683.9654e-03-0.1742image
ENSG00000148153.12,INIPGBMEAG2.3300e-02-0.17603.3917e-02-0.16475.5397e-05-0.30762.5198e-02-0.1737image
chr9:112684242-112685344:-LUADEER1.9806e-020.10321.1056e-020.11254.8271e-020.08762.0476e-030.1364image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000148153.12,INIPBLCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.3144e-03-0.1417image
chr9:112684242-112685344:-BLCAGSVA_HALLMARK_MITOTIC_SPINDLEEER1.2145e-02-0.1247image
chr9:112684242-112685344:-BRCAGSVA_HALLMARK_HEME_METABOLISMEER1.3360e-04-0.1160image
ENSG00000148153.12,INIPBRCAGSVA_HALLMARK_UV_RESPONSE_DNEAG7.3393e-06-0.1359image
ENSG00000148153.12,INIPCESCGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.9125e-05-0.2377image
chr9:112684242-112685344:-CESCGSVA_HALLMARK_PROTEIN_SECRETIONEER7.4345e-05-0.2256image
chr9:112684242-112685344:-COADGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER7.8031e-07-0.2948image
ENSG00000148153.12,INIPCOADGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG2.4851e-08-0.3300image
ENSG00000148153.12,INIPDLBCGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG2.7854e-02-0.3176image
chr9:112684242-112685344:-DLBCGSVA_HALLMARK_TGF_BETA_SIGNALINGEER4.2030e-02-0.2947image
ENSG00000148153.12,INIPESCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.4712e-04-0.2743image
chr9:112684242-112685344:-ESCAGSVA_HALLMARK_MITOTIC_SPINDLEEER2.7642e-03-0.2358image
chr9:112684242-112685344:-GBMGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER6.6942e-03-0.2097image
ENSG00000148153.12,INIPGBMGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG4.3333e-04-0.2701image
ENSG00000148153.12,INIPHNSCGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG1.3277e-05-0.1934image
chr9:112684242-112685344:-HNSCGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER2.0321e-04-0.1654image
ENSG00000148153.12,INIPKIRCGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG4.3317e-06-0.2326image
chr9:112684242-112685344:-KIRCGSVA_HALLMARK_TGF_BETA_SIGNALINGEER1.8872e-05-0.2173image
ENSG00000148153.12,INIPKIRPGSVA_HALLMARK_HEME_METABOLISMEAG7.8585e-12-0.3888image
chr9:112684242-112685344:-KIRPGSVA_HALLMARK_HEME_METABOLISMEER1.2795e-10-0.3671image
chr9:112684242-112685344:-LAMLGSVA_HALLMARK_E2F_TARGETSEER2.4674e-03-0.2685image
ENSG00000148153.12,INIPLAMLGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.8794e-030.2624image
chr9:112684242-112685344:-LGGGSVA_HALLMARK_MYC_TARGETS_V1EER6.0334e-04-0.1487image
ENSG00000148153.12,INIPLGGGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.7696e-05-0.1854image
ENSG00000148153.12,INIPLIHCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG1.2677e-070.2715image
chr9:112684242-112685344:-LIHCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER3.0150e-070.2636image
ENSG00000148153.12,INIPLUADGSVA_HALLMARK_GLYCOLYSISEAG2.2520e-050.1865image
chr9:112684242-112685344:-LUADGSVA_HALLMARK_GLYCOLYSISEER8.9930e-060.1954image
ENSG00000148153.12,INIPLUSCGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG6.9053e-05-0.1775image
chr9:112684242-112685344:-LUSCGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER1.4395e-04-0.1697image
chr9:112684242-112685344:-MESOGSVA_HALLMARK_NOTCH_SIGNALINGEER3.4289e-02-0.2341image
chr9:112684242-112685344:-OVGSVA_HALLMARK_MITOTIC_SPINDLEEER5.3609e-06-0.2632image
ENSG00000148153.12,INIPOVGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.6783e-08-0.3188image
ENSG00000148153.12,INIPPAADGSVA_HALLMARK_SPERMATOGENESISEAG2.6428e-04-0.2717image
chr9:112684242-112685344:-PAADGSVA_HALLMARK_SPERMATOGENESISEER7.2064e-04-0.2526image
ENSG00000148153.12,INIPPCPGGSVA_HALLMARK_MITOTIC_SPINDLEEAG9.7499e-08-0.3827image
chr9:112684242-112685344:-PCPGGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER3.9267e-07-0.3654image
chr9:112684242-112685344:-PRADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER2.3913e-08-0.2468image
ENSG00000148153.12,INIPPRADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG1.6868e-09-0.2658image
ENSG00000148153.12,INIPSARCGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG6.8505e-05-0.2457image
chr9:112684242-112685344:-SARCGSVA_HALLMARK_TGF_BETA_SIGNALINGEER9.7335e-05-0.2407image
chr9:112684242-112685344:-SKCMGSVA_HALLMARK_UV_RESPONSE_DNEER1.4639e-05-0.2004image
ENSG00000148153.12,INIPSKCMGSVA_HALLMARK_UV_RESPONSE_DNEAG1.4954e-06-0.2219image
chr9:112684242-112685344:-STADGSVA_HALLMARK_MITOTIC_SPINDLEEER4.6456e-04-0.1826image
chr9:112686544-112686779:-STADGSVA_HALLMARK_MITOTIC_SPINDLEEER1.0124e-03-0.1858image
ENSG00000148153.12,INIPSTADGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.6804e-05-0.2232image
chr9:112684242-112685344:-TGCTGSVA_HALLMARK_TGF_BETA_SIGNALINGEER2.9007e-03-0.2408image
ENSG00000148153.12,INIPTGCTGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG2.0667e-03-0.2488image
ENSG00000148153.12,INIPTHCAGSVA_HALLMARK_HEME_METABOLISMEAG7.3921e-07-0.2184image
chr9:112684242-112685344:-THCAGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER3.4508e-05-0.1834image
ENSG00000148153.12,INIPTHYMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG8.5335e-050.3566image
chr9:112684242-112685344:-THYMGSVA_HALLMARK_KRAS_SIGNALING_DNEER4.2828e-050.3703image
chr9:112684242-112685344:-UCECGSVA_HALLMARK_ANDROGEN_RESPONSEEER7.4509e-06-0.3333image
ENSG00000148153.12,INIPUCECGSVA_HALLMARK_PROTEIN_SECRETIONEAG8.1530e-06-0.3310image
chr9:112684242-112685344:-UVMGSVA_HALLMARK_APICAL_SURFACEEER2.1416e-050.5080image
ENSG00000148153.12,INIPUVMGSVA_HALLMARK_APICAL_SURFACEEAG1.6495e-050.5139image


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7. Enriched editing regions and drugs for INIP


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr9:112684242-112685344:-ACCAICAREER1.8097e-02-0.2671image
ENSG00000148153.12,INIPACCAICAREAG1.8677e-02-0.2658image
chr9:112684242-112685344:-BLCAAZD6244EER1.5530e-03-0.1570image
ENSG00000148153.12,INIPBLCAAZD6244EAG8.0893e-04-0.1660image
ENSG00000148153.12,INIPBRCACMKEAG7.9729e-05-0.1198image
chr9:112684242-112685344:-BRCACMKEER7.5832e-05-0.1202image
ENSG00000148153.12,INIPCESCDasatinibEAG4.3686e-07-0.2858image
chr9:112684242-112685344:-CESCDasatinibEER7.0280e-07-0.2809image
chr9:112684242-112685344:-CHOLDocetaxelEER4.8143e-020.3364image
ENSG00000148153.12,INIPCOADBMS.509744EAG5.0915e-110.3846image
chr9:112684242-112685344:-COADBMS.509744EER5.2201e-100.3659image
chr9:112684242-112685344:-DLBCCyclopamineEER8.3021e-03-0.3768image
ENSG00000148153.12,INIPDLBCCyclopamineEAG7.0908e-03-0.3838image
chr9:112684242-112685344:-ESCAGNF.2EER1.2596e-04-0.2994image
ENSG00000148153.12,INIPESCAGNF.2EAG6.6427e-04-0.2663image
chr9:112684242-112685344:-GBMGefitinibEER1.4193e-02-0.1900image
ENSG00000148153.12,INIPGBMGefitinibEAG4.8050e-03-0.2179image
ENSG00000148153.12,INIPHNSCATRAEAG1.0718e-060.2161image
chr9:112684242-112685344:-HNSCATRAEER2.2145e-050.1885image
ENSG00000148153.12,INIPKICHABT.888EAG1.7911e-03-0.3801image
chr9:112684242-112685344:-KICHABT.888EER1.5857e-03-0.3841image
ENSG00000148153.12,INIPKIRCFH535EAG1.0773e-060.2465image
chr9:112684242-112685344:-KIRCFH535EER1.5120e-060.2435image
ENSG00000148153.12,INIPKIRPBIRB.0796EAG4.3249e-06-0.2670image
chr9:112684242-112685344:-KIRPBIRB.0796EER4.8287e-06-0.2657image
chr9:112684242-112685344:-LAMLCHIR.99021EER4.2530e-05-0.3575image
ENSG00000148153.12,INIPLAMLCHIR.99021EAG8.7188e-05-0.3410image
ENSG00000148153.12,INIPLGGBI.2536EAG1.0004e-050.1907image
chr9:112684242-112685344:-LGGBI.2536EER1.8772e-050.1849image
ENSG00000148153.12,INIPLIHCAUY922EAG2.3505e-120.3552image
chr9:112684242-112685344:-LIHCAUY922EER7.5535e-120.3474image
chr9:112684242-112685344:-LUADAZD.0530EER7.5778e-05-0.1745image
ENSG00000148153.12,INIPLUADDocetaxelEAG5.9144e-05-0.1769image
ENSG00000148153.12,INIPLUSCGSK269962AEAG1.6703e-04-0.1681image
chr9:112684242-112685344:-LUSCGSK269962AEER2.0945e-04-0.1656image
chr9:112684242-112685344:-MESOMetforminEER3.3490e-020.2351image
ENSG00000148153.12,INIPMESOMetforminEAG3.7911e-020.2297image
ENSG00000148153.12,INIPOVBMS.536924EAG3.7235e-10-0.3567image
chr9:112684242-112685344:-OVBMS.536924EER8.2092e-08-0.3080image
chr9:112684242-112685344:-PAADAZD6482EER7.4666e-050.2990image
ENSG00000148153.12,INIPPAADAZD6482EAG3.1067e-050.3137image
chr9:112684242-112685344:-PCPGAZD6244EER8.4542e-04-0.2453image
ENSG00000148153.12,INIPPCPGAZD6244EAG3.4942e-04-0.2622image
ENSG00000148153.12,INIPPRADBMS.509744EAG1.4492e-04-0.1695image
chr9:112684242-112685344:-PRADAZD.2281EER1.4987e-03-0.1422image
chr9:112684242-112685344:-READBosutinibEER2.1694e-020.2366image
ENSG00000148153.12,INIPREADBosutinibEAG2.5395e-020.2305image
ENSG00000148153.12,INIPSARCErlotinibEAG1.0195e-06-0.2993image
chr9:112684242-112685344:-SARCErlotinibEER1.6463e-06-0.2938image
ENSG00000148153.12,INIPSKCMGNF.2EAG1.2698e-09-0.2779image
chr9:112684242-112685344:-SKCMGNF.2EER1.0656e-08-0.2624image
chr9:112686544-112686779:-STADElesclomolEER1.0815e-04-0.2181image
ENSG00000148153.12,INIPSTADBMS.509744EAG6.0535e-05-0.2083image
chr9:112684242-112685344:-STADJNJ.26854165EER2.5752e-04-0.1907image
ENSG00000148153.12,INIPTGCTAUY922EAG4.5697e-030.2296image
chr9:112684242-112685344:-TGCTAUY922EER5.2732e-030.2260image
chr9:112684242-112685344:-THCAEmbelinEER3.2865e-110.2898image
ENSG00000148153.12,INIPTHCAEmbelinEAG7.5199e-140.3249image
ENSG00000148153.12,INIPTHYMEmbelinEAG8.7873e-070.4380image
chr9:112684242-112685344:-THYMAZD6244EER3.7661e-06-0.4144image
chr9:112684242-112685344:-UCECA.770041EER8.6944e-19-0.6069image
ENSG00000148153.12,INIPUCECA.770041EAG4.9661e-19-0.6089image
ENSG00000148153.12,INIPUCSBMS.708163EAG1.9571e-020.3112image
chr9:112684242-112685344:-UCSMetforminEER1.7736e-02-0.3158image
chr9:112684242-112685344:-UVMBexaroteneEER3.3953e-06-0.5477image
ENSG00000148153.12,INIPUVMBexaroteneEAG2.0754e-06-0.5575image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType