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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: METTL14 (ImmuneEditome ID:57721)

1. Gene summary of enriched editing regions for METTL14

check button Gene summary
Gene informationGene symbol

METTL14

Gene ID

57721

GeneSynonymshMETTL14
GeneCytomap

4q26

GeneTypeprotein-coding
GeneDescriptionN6-adenosine-methyltransferase non-catalytic subunit|N6-adenosine-methyltransferase subunit METTL14|methyltransferase like 14|methyltransferase-like protein 14
GeneModificationdate20230501
UniprotIDQ9HCE5;D6RD73;A0A0D9SFW0;A0A0D9SF88
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr4:118714563-118714865:+ENST00000388822.8ENSG00000145388.13METTL14UTR3AluSx1chr4:118714563-118714865:+.alignment
chr4:118714563-118714865:+ENST00000628452.1ENSG00000145388.13METTL14UTR3AluSx1chr4:118714563-118714865:+.alignment


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2. Tumor-specific enriched editing regions for METTL14


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
ENSG00000145388.13,METTL14BRCAEAG8.3655e-05image
ENSG00000145388.13,METTL14LUSCEAG4.5533e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000145388.13,METTL14BLCAPathEAG5.7704e-031.0640e-030.3093image
chr4:118714563-118714865:+BLCAPathEER5.6021e-031.0454e-030.3098image
chr4:118714563-118714865:+KIRPCliEER2.2392e-021.7998e-020.2862image
ENSG00000145388.13,METTL14KIRPCliEAG1.8349e-021.3227e-020.2969image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for METTL14


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for METTL14


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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5. Enriched editing regions and immune infiltration for METTL14


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000145388.13,METTL14ACCEAGEosinophils1.6733e-020.3474image
chr4:118714563-118714865:+BLCAEERMacrophages_M12.1452e-020.2201image
ENSG00000145388.13,METTL14BLCAEAGMacrophages_M12.0147e-020.2223image
ENSG00000145388.13,METTL14BRCAEAGMacrophages_M13.6067e-030.1113image
ENSG00000145388.13,METTL14COADEAGT_cells_gamma_delta2.2590e-020.4633image
ENSG00000145388.13,METTL14ESCAEAGB_cells_naive1.7712e-02-0.2890image
chr4:118714563-118714865:+HNSCEERB_cells_memory7.4468e-03-0.2971image
ENSG00000145388.13,METTL14HNSCEAGMacrophages_M24.3839e-030.3097image
chr4:118714563-118714865:+KICHEERMacrophages_M14.0098e-030.4946image
ENSG00000145388.13,METTL14KICHEAGMacrophages_M14.0098e-030.4946image
chr4:118714563-118714865:+KIRCEERT_cells_CD4_memory_activated2.3751e-030.2204image
ENSG00000145388.13,METTL14KIRCEAGT_cells_CD4_memory_activated8.8302e-030.1880image
chr4:118714563-118714865:+KIRPEERT_cells_CD4_memory_activated4.3926e-030.2826image
ENSG00000145388.13,METTL14KIRPEAGT_cells_CD4_memory_activated4.1884e-030.2826image
chr4:118714563-118714865:+LGGEERMacrophages_M14.5458e-020.1385image
chr4:118714563-118714865:+LUADEERT_cells_CD4_memory_activated9.8835e-030.2834image
ENSG00000145388.13,METTL14LUADEAGT_cells_CD4_memory_activated1.2720e-020.2708image
ENSG00000145388.13,METTL14LUSCEAGB_cells_naive4.4429e-020.2483image
ENSG00000145388.13,METTL14OVEAGB_cells_naive1.2291e-02-0.2721image
chr4:118714563-118714865:+PCPGEERNeutrophils2.6533e-030.3220image
ENSG00000145388.13,METTL14PCPGEAGNeutrophils2.4758e-030.3241image
chr4:118714563-118714865:+PRADEERMonocytes3.0708e-02-0.1318image
ENSG00000145388.13,METTL14PRADEAGMonocytes4.5011e-02-0.1221image
chr4:118714563-118714865:+SKCMEERMacrophages_M01.4315e-02-0.1996image
ENSG00000145388.13,METTL14SKCMEAGMacrophages_M09.7483e-03-0.2097image
chr4:118714563-118714865:+TGCTEERT_cells_CD4_memory_activated9.6749e-040.4526image
ENSG00000145388.13,METTL14TGCTEAGT_cells_CD4_memory_activated1.0188e-030.4466image
ENSG00000145388.13,METTL14THCAEAGT_cells_CD4_memory_resting1.6817e-020.1251image
chr4:118714563-118714865:+THYMEERDendritic_cells_activated7.4023e-030.2955image
ENSG00000145388.13,METTL14THYMEAGMast_cells_resting4.3437e-030.3137image
chr4:118714563-118714865:+UCECEERPlasma_cells4.4074e-02-0.2804image
ENSG00000145388.13,METTL14UCECEAGT_cells_CD4_memory_activated4.6808e-020.2770image


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6. Enriched editing regions and immune gene sets for METTL14


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000145388.13,METTL14ACCGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG4.3885e-02-0.2953image
chr4:118714563-118714865:+BLCAGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER1.1230e-050.4070image
ENSG00000145388.13,METTL14BLCAGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG9.7851e-060.4095image
ENSG00000145388.13,METTL14BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.6423e-070.1890image
ENSG00000145388.13,METTL14COADGSVA_HALLMARK_DNA_REPAIREAG4.8728e-03-0.5550image
ENSG00000145388.13,METTL14GBMGSVA_HALLMARK_PEROXISOMEEAG4.5443e-020.2530image
chr4:118714563-118714865:+HNSCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.9376e-020.2610image
ENSG00000145388.13,METTL14HNSCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.9726e-020.2555image
ENSG00000145388.13,METTL14KIRCGSVA_HALLMARK_E2F_TARGETSEAG1.7045e-020.1716image
chr4:118714563-118714865:+KIRCGSVA_HALLMARK_E2F_TARGETSEER5.0107e-030.2039image
chr4:118714563-118714865:+KIRPGSVA_HALLMARK_DNA_REPAIREER2.4880e-02-0.2243image
ENSG00000145388.13,METTL14KIRPGSVA_HALLMARK_DNA_REPAIREAG1.9836e-02-0.2315image
ENSG00000145388.13,METTL14LGGGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG2.5964e-02-0.1533image
chr4:118714563-118714865:+LIHCGSVA_HALLMARK_SPERMATOGENESISEER4.1837e-02-0.1971image
ENSG00000145388.13,METTL14LIHCGSVA_HALLMARK_SPERMATOGENESISEAG4.3855e-02-0.1953image
chr4:118714563-118714865:+LUADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER1.5816e-020.2658image
ENSG00000145388.13,METTL14LUADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG2.5327e-020.2440image
ENSG00000145388.13,METTL14LUSCGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG1.2047e-02-0.3074image
chr4:118714563-118714865:+LUSCGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER4.8981e-02-0.2511image
ENSG00000145388.13,METTL14OVGSVA_HALLMARK_SPERMATOGENESISEAG2.7768e-02-0.2402image
chr4:118714563-118714865:+PAADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.4544e-020.4040image
ENSG00000145388.13,METTL14PAADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.4544e-020.4040image
chr4:118714563-118714865:+SARCGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER3.4602e-020.2095image
ENSG00000145388.13,METTL14SARCGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG3.4293e-020.2098image
chr4:118714563-118714865:+TGCTGSVA_HALLMARK_NOTCH_SIGNALINGEER1.4533e-02-0.3437image
ENSG00000145388.13,METTL14TGCTGSVA_HALLMARK_NOTCH_SIGNALINGEAG1.6965e-02-0.3330image
ENSG00000145388.13,METTL14THCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.9919e-030.1550image
ENSG00000145388.13,METTL14THYMGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG2.0675e-030.3374image
chr4:118714563-118714865:+THYMGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER2.1925e-030.3356image


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7. Enriched editing regions and drugs for METTL14


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000145388.13,METTL14ACCElesclomolEAG3.0081e-020.3167image
chr4:118714563-118714865:+BLCAEHT.1864EER1.1777e-030.3068image
ENSG00000145388.13,METTL14BLCAEHT.1864EAG1.0225e-030.3104image
ENSG00000145388.13,METTL14BRCACGP.082996EAG1.3859e-03-0.1222image
ENSG00000145388.13,METTL14CESCAICAREAG1.4046e-02-0.2807image
chr4:118714563-118714865:+CESCAICAREER1.4046e-02-0.2807image
ENSG00000145388.13,METTL14COADGDC.0449EAG9.3318e-040.6315image
ENSG00000145388.13,METTL14ESCACytarabineEAG9.3804e-030.3152image
chr4:118714563-118714865:+HNSCBleomycinEER3.7807e-03-0.3202image
ENSG00000145388.13,METTL14HNSCBleomycinEAG5.2839e-03-0.3035image
chr4:118714563-118714865:+KIRCCisplatinEER1.7462e-02-0.1732image
ENSG00000145388.13,METTL14KIRCJNJ.26854165EAG3.0946e-02-0.1554image
ENSG00000145388.13,METTL14LGGBAY.61.3606EAG1.5853e-020.1659image
chr4:118714563-118714865:+LIHCAZD7762EER4.6690e-020.1928image
ENSG00000145388.13,METTL14LIHCAZD7762EAG4.9722e-020.1902image
chr4:118714563-118714865:+LUADLapatinibEER6.1780e-03-0.3000image
ENSG00000145388.13,METTL14LUADLapatinibEAG4.2496e-03-0.3089image
ENSG00000145388.13,METTL14LUSCLFM.A13EAG8.1621e-050.4656image
chr4:118714563-118714865:+LUSCLFM.A13EER5.5575e-040.4260image
ENSG00000145388.13,METTL14OVBMS.536924EAG5.0378e-04-0.3714image
ENSG00000145388.13,METTL14PAADJW.7.52.1EAG2.0964e-03-0.4960image
chr4:118714563-118714865:+PAADJW.7.52.1EER2.0964e-03-0.4960image
chr4:118714563-118714865:+PRADBI.D1870EER1.9417e-050.2572image
ENSG00000145388.13,METTL14PRADMetforminEAG4.1331e-040.2134image
chr4:118714563-118714865:+SARCCMKEER1.2411e-030.3154image
ENSG00000145388.13,METTL14SARCCMKEAG1.7248e-030.3066image
ENSG00000145388.13,METTL14SKCMDocetaxelEAG4.0058e-020.1673image
chr4:118714563-118714865:+SKCMDocetaxelEER2.5758e-020.1821image
ENSG00000145388.13,METTL14STADABT.263EAG8.9048e-03-0.2590image
chr4:118714563-118714865:+TGCTCI.1040EER3.8438e-02-0.2937image
ENSG00000145388.13,METTL14TGCTCI.1040EAG3.4877e-02-0.2961image
ENSG00000145388.13,METTL14THCAAG.014699EAG4.8264e-030.1472image
ENSG00000145388.13,METTL14THYMEmbelinEAG1.5953e-030.3453image
chr4:118714563-118714865:+THYMEmbelinEER1.0696e-030.3570image
ENSG00000145388.13,METTL14UCECDMOGEAG2.0881e-030.4172image
chr4:118714563-118714865:+UCECDMOGEER1.6288e-030.4262image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType