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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: MAVS (ImmuneEditome ID:57506)

1. Gene summary of enriched editing regions for MAVS

check button Gene summary
Gene informationGene symbol

MAVS

Gene ID

57506

GeneSynonymsCARDIF|IPS-1|IPS1|VISA
GeneCytomap

20p13

GeneTypeprotein-coding
GeneDescriptionmitochondrial antiviral-signaling protein|CARD adapter inducing interferon beta|CARD adaptor inducing IFN-beta|IFN-B promoter stimulator 1|interferon beta promoter stimulator protein 1|putative NF-kappa-B-activating protein 031N|virus-induced signaling adaptor|virus-induced-signaling adapter
GeneModificationdate20230521
UniprotIDQ7Z434
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr20:3850927-3851897:+ENST00000416600.5ENSG00000088888.16MAVSintronicMIR3,AluSx1,AluSp,AluSxchr20:3850927-3851897:+.alignment
chr20:3850927-3851897:+ENST00000428216.3ENSG00000088888.16MAVSintronicMIR3,AluSx1,AluSp,AluSxchr20:3850927-3851897:+.alignment
chr20:3853608-3853963:+ENST00000416600.5ENSG00000088888.16MAVSintronicAluJr,AluSpchr20:3853608-3853963:+.alignment
chr20:3853608-3853963:+ENST00000428216.3ENSG00000088888.16MAVSintronicAluJr,AluSpchr20:3853608-3853963:+.alignment
chr20:3858453-3858949:+ENST00000416600.5ENSG00000088888.16MAVSintronicAluJo,AluSc8chr20:3858453-3858949:+.alignment
chr20:3858453-3858949:+ENST00000428216.3ENSG00000088888.16MAVSintronicAluJo,AluSc8chr20:3858453-3858949:+.alignment
chr20:3867382-3873565:+ENST00000416600.5ENSG00000088888.16MAVSUTR3L1MC5,AluSz,L2a,MLT1A0,AluSx4,AluJr4,AluJr,FLAM_C,MIR,AluSx1,AluY,L1ME3Achr20:3867382-3873565:+.alignment
chr20:3867382-3873565:+ENST00000428216.3ENSG00000088888.16MAVSUTR3L1MC5,AluSz,L2a,MLT1A0,AluSx4,AluJr4,AluJr,FLAM_C,MIR,AluSx1,AluY,L1ME3Achr20:3867382-3873565:+.alignment
chr20:3875123-3875384:+ENST00000416600.5ENSG00000088888.16MAVSUTR3AluJrchr20:3875123-3875384:+.alignment
chr20:3875123-3875384:+ENST00000428216.3ENSG00000088888.16MAVSUTR3AluJrchr20:3875123-3875384:+.alignment


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2. Tumor-specific enriched editing regions for MAVS


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr20:3867382-3873565:+BRCAEER1.2583e-10image
ENSG00000088888.16,MAVSBRCAEAG1.2009e-09image
chr20:3867382-3873565:+COADEER3.0512e-14image
ENSG00000088888.16,MAVSCOADEAG3.5452e-13image
chr20:3867382-3873565:+HNSCEER7.9997e-07image
ENSG00000088888.16,MAVSHNSCEAG2.0934e-06image
chr20:3867382-3873565:+KICHEER6.5780e-07image
ENSG00000088888.16,MAVSKICHEAG6.5780e-07image
chr20:3867382-3873565:+KIRCEER6.2941e-05image
ENSG00000088888.16,MAVSKIRCEAG1.4756e-05image
chr20:3867382-3873565:+KIRPEER8.2158e-07image
ENSG00000088888.16,MAVSKIRPEAG7.7404e-07image
chr20:3867382-3873565:+LIHCEER6.8325e-04image
chr20:3867382-3873565:+PRADEER3.0525e-08image
ENSG00000088888.16,MAVSPRADEAG1.3973e-08image
chr20:3867382-3873565:+THCAEER8.0663e-03image
ENSG00000088888.16,MAVSTHCAEAG8.9636e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000088888.16,MAVSBLCAPathEAG1.1164e-021.3990e-030.1582image
ENSG00000088888.16,MAVSHNSCCliEAG2.1716e-026.0008e-030.1246image
chr20:3867382-3873565:+HNSCCliEER3.4106e-028.7095e-030.1190image
chr20:3867382-3873565:+READPathEER3.8964e-021.5324e-02-0.1957image
ENSG00000088888.16,MAVSTHCAPathEAG1.9488e-031.5951e-020.1074image
chr20:3867382-3873565:+THCAPathEER1.5285e-031.3309e-020.1103image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
ENSG00000088888.16,MAVSCOADEAG2.3292e-021.6846e-023.6734e+03image

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3. Enriched editing regions and immune related genes for MAVS


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr20:3867382-3873565:+DLBCEERENSG00000024862,CCDC28A-0.52334.0465e-024.5731e-03-0.4024imageNBUD13;CELF2;CNBP;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FXR2;HNRNPA1;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;IGF2BP3;LARP4B;LIN28;LIN28B;MSI2;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;U2AF1;U2AF2;XRN2;ADAR;HNRNPU;UPF1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MYC_TARGETS_V2
chr20:3867382-3873565:+DLBCEERENSG00000024862,CCDC28A-0.52334.0465e-024.5731e-03-0.4024imageNBUD13;CELF2;CNBP;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FXR2;HNRNPA1;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;IGF2BP3;LARP4B;LIN28;LIN28B;MSI2;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;U2AF1;U2AF2;XRN2;ADAR;HNRNPU;UPF1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MYC_TARGETS_V2

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4. Enriched editing regions and immune related splicing for MAVS


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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5. Enriched editing regions and immune infiltration for MAVS


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr20:3867382-3873565:+BLCAEERT_cells_regulatory_(Tregs)1.6583e-04-0.1865image
ENSG00000088888.16,MAVSBLCAEAGT_cells_regulatory_(Tregs)1.2351e-04-0.1898image
chr20:3867382-3873565:+BRCAEERDendritic_cells_activated3.0583e-050.1263image
ENSG00000088888.16,MAVSBRCAEAGDendritic_cells_activated3.0720e-060.1412image
ENSG00000088888.16,MAVSCESCEAGNeutrophils4.0631e-020.1175image
chr20:3867382-3873565:+CHOLEERT_cells_follicular_helper1.2524e-030.5234image
ENSG00000088888.16,MAVSCHOLEAGT_cells_follicular_helper1.2524e-030.5234image
chr20:3867382-3873565:+COADEERDendritic_cells_activated3.7449e-040.2126image
ENSG00000088888.16,MAVSCOADEAGDendritic_cells_activated4.5382e-040.2097image
chr20:3867382-3873565:+DLBCEERMacrophages_M22.1504e-020.3311image
ENSG00000088888.16,MAVSDLBCEAGMacrophages_M22.6187e-020.3209image
chr20:3867382-3873565:+ESCAEERT_cells_regulatory_(Tregs)9.4023e-03-0.2041image
ENSG00000088888.16,MAVSESCAEAGT_cells_regulatory_(Tregs)1.5026e-02-0.1914image
chr20:3867382-3873565:+GBMEERMonocytes2.5610e-030.2319image
ENSG00000088888.16,MAVSGBMEAGMonocytes4.9490e-030.2165image
chr20:3867382-3873565:+HNSCEERNK_cells_resting3.8871e-030.1292image
ENSG00000088888.16,MAVSHNSCEAGNK_cells_resting2.3205e-030.1362image
chr20:3867382-3873565:+KICHEERMacrophages_M22.6715e-02-0.2748image
ENSG00000088888.16,MAVSKICHEAGMacrophages_M22.6715e-02-0.2748image
chr20:3867382-3873565:+KIRCEERNK_cells_activated1.7526e-02-0.1212image
chr20:3867382-3873565:+KIRPEERMacrophages_M16.4673e-050.2332image
ENSG00000088888.16,MAVSKIRPEAGMacrophages_M16.6624e-050.2328image
chr20:3867382-3873565:+LAMLEERT_cells_CD83.7093e-030.2356image
ENSG00000088888.16,MAVSLAMLEAGT_cells_CD83.6537e-030.2359image
chr20:3867382-3873565:+LGGEERMacrophages_M21.1572e-04-0.1668image
ENSG00000088888.16,MAVSLGGEAGMacrophages_M28.4305e-05-0.1701image
chr20:3867382-3873565:+LIHCEERMacrophages_M16.9214e-030.1407image
ENSG00000088888.16,MAVSLIHCEAGMacrophages_M15.9708e-030.1431image
chr20:3867382-3873565:+LUADEERT_cells_gamma_delta1.6207e-050.1891image
ENSG00000088888.16,MAVSLUADEAGT_cells_gamma_delta1.4457e-040.1668image
chr20:3850927-3851897:+OVEERPlasma_cells6.3575e-030.4794image
chr20:3867382-3873565:+OVEERT_cells_CD85.0880e-040.2022image
ENSG00000088888.16,MAVSOVEAGT_cells_CD82.6005e-030.1756image
chr20:3867382-3873565:+PCPGEERMacrophages_M25.2957e-03-0.2053image
ENSG00000088888.16,MAVSPCPGEAGMacrophages_M26.3888e-03-0.2009image
chr20:3867382-3873565:+PRADEERT_cells_CD4_memory_resting7.0277e-080.2384image
ENSG00000088888.16,MAVSPRADEAGT_cells_CD4_memory_resting5.0194e-080.2410image
chr20:3867382-3873565:+READEERMast_cells_activated2.4192e-020.2312image
ENSG00000088888.16,MAVSREADEAGMast_cells_activated2.4192e-020.2312image
chr20:3867382-3873565:+SARCEERNK_cells_resting9.4770e-03-0.1615image
ENSG00000088888.16,MAVSSARCEAGNK_cells_resting2.6854e-02-0.1381image
chr20:3867382-3873565:+SKCMEERB_cells_naive2.8975e-02-0.1006image
ENSG00000088888.16,MAVSSKCMEAGMast_cells_resting2.8633e-020.1008image
chr20:3867382-3873565:+STADEERT_cells_regulatory_(Tregs)2.2549e-060.2433image
ENSG00000088888.16,MAVSSTADEAGT_cells_regulatory_(Tregs)2.8044e-060.2411image
chr20:3867382-3873565:+TGCTEERT_cells_CD4_memory_activated6.2170e-030.2182image
ENSG00000088888.16,MAVSTGCTEAGT_cells_CD4_memory_activated2.0711e-020.1851image
chr20:3867382-3873565:+THCAEERNK_cells_activated7.1411e-09-0.2542image
ENSG00000088888.16,MAVSTHCAEAGNK_cells_activated3.8273e-09-0.2586image
chr20:3867382-3873565:+THYMEERMacrophages_M21.5914e-030.2876image
ENSG00000088888.16,MAVSTHYMEAGMacrophages_M21.5914e-030.2876image
chr20:3867382-3873565:+UCECEERPlasma_cells4.8189e-030.2104image
ENSG00000088888.16,MAVSUCECEAGPlasma_cells5.9518e-030.2054image
chr20:3867382-3873565:+UCSEERNK_cells_resting7.1123e-030.3558image
ENSG00000088888.16,MAVSUCSEAGNK_cells_resting4.3595e-030.3754image
ENSG00000088888.16,MAVSUVMEAGNeutrophils4.8381e-020.2214image


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6. Enriched editing regions and immune gene sets for MAVS


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr20:3867382-3873565:+STADEER4.4447e-02image2.6471e-060.2417image
ENSG00000088888.16,MAVSSTADEAG4.9494e-02image4.7935e-060.2355image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr20:3867382-3873565:+BLCAEER5.4662e-030.13821.4271e-020.12201.4577e-020.12161.0503e-080.2802image
chr20:3867382-3873565:+LIHCEER1.0228e-02-0.13392.5703e-03-0.15691.0929e-03-0.16983.4180e-040.1860image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000088888.16,MAVSACCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.4568e-020.2381image
chr20:3867382-3873565:+ACCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.7871e-020.2341image
ENSG00000088888.16,MAVSBLCAGSVA_HALLMARK_UV_RESPONSE_DNEAG2.9308e-100.3069image
chr20:3867382-3873565:+BLCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER3.7136e-090.2884image
chr20:3867382-3873565:+BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER6.6310e-060.1364image
ENSG00000088888.16,MAVSBRCAGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.5680e-050.1308image
ENSG00000088888.16,MAVSCESCGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG4.2297e-030.1636image
chr20:3867382-3873565:+CESCGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER1.0380e-030.1875image
chr20:3867382-3873565:+CHOLGSVA_HALLMARK_DNA_REPAIREER3.8842e-03-0.4756image
ENSG00000088888.16,MAVSCHOLGSVA_HALLMARK_DNA_REPAIREAG3.8842e-03-0.4756image
ENSG00000088888.16,MAVSCOADGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG1.0396e-060.2890image
chr20:3867382-3873565:+COADGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER9.6013e-070.2899image
ENSG00000088888.16,MAVSESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG4.9840e-030.2203image
chr20:3867382-3873565:+ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER2.1006e-030.2407image
chr20:3867382-3873565:+GBMGSVA_HALLMARK_MYC_TARGETS_V2EER5.2208e-04-0.2656image
ENSG00000088888.16,MAVSGBMGSVA_HALLMARK_MYC_TARGETS_V2EAG4.2824e-04-0.2695image
ENSG00000088888.16,MAVSHNSCGSVA_HALLMARK_HYPOXIAEAG3.7348e-070.2254image
chr20:3867382-3873565:+HNSCGSVA_HALLMARK_HYPOXIAEER2.1613e-070.2298image
chr20:3867382-3873565:+KICHGSVA_HALLMARK_HEME_METABOLISMEER1.1739e-030.3938image
ENSG00000088888.16,MAVSKICHGSVA_HALLMARK_HEME_METABOLISMEAG1.1739e-030.3938image
ENSG00000088888.16,MAVSKIRCGSVA_HALLMARK_MITOTIC_SPINDLEEAG6.5418e-040.1729image
chr20:3867382-3873565:+KIRCGSVA_HALLMARK_MITOTIC_SPINDLEEER9.6924e-030.1318image
chr20:3875123-3875384:+KIRCGSVA_HALLMARK_SPERMATOGENESISEER8.6162e-030.4787image
ENSG00000088888.16,MAVSKIRPGSVA_HALLMARK_HEME_METABOLISMEAG7.1648e-100.3529image
chr20:3867382-3873565:+KIRPGSVA_HALLMARK_HEME_METABOLISMEER7.2042e-100.3529image
chr20:3867382-3873565:+LAMLGSVA_HALLMARK_SPERMATOGENESISEER7.6108e-03-0.2171image
ENSG00000088888.16,MAVSLAMLGSVA_HALLMARK_SPERMATOGENESISEAG7.3777e-03-0.2179image
chr20:3867382-3873565:+LGGGSVA_HALLMARK_DNA_REPAIREER1.7352e-12-0.3003image
ENSG00000088888.16,MAVSLGGGSVA_HALLMARK_DNA_REPAIREAG2.1548e-12-0.2991image
ENSG00000088888.16,MAVSLIHCGSVA_HALLMARK_ANDROGEN_RESPONSEEAG2.6631e-080.2849image
chr20:3867382-3873565:+LIHCGSVA_HALLMARK_COAGULATIONEER6.6773e-060.2326image
chr20:3867382-3873565:+LUADGSVA_HALLMARK_PEROXISOMEEER1.0275e-060.2138image
ENSG00000088888.16,MAVSLUADGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG9.1124e-070.2146image
ENSG00000088888.16,MAVSLUSCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG8.4236e-040.1491image
chr20:3867382-3873565:+LUSCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER9.9496e-050.1737image
ENSG00000088888.16,MAVSMESOGSVA_HALLMARK_MTORC1_SIGNALINGEAG1.3078e-03-0.3511image
chr20:3867382-3873565:+MESOGSVA_HALLMARK_MYC_TARGETS_V1EER1.3150e-02-0.2745image
ENSG00000088888.16,MAVSOVGSVA_HALLMARK_DNA_REPAIREAG1.5032e-090.3443image
chr20:3867382-3873565:+OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.1270e-100.3658image
chr20:3850927-3851897:+OVGSVA_HALLMARK_ANDROGEN_RESPONSEEER4.6234e-02-0.3607image
chr20:3867382-3873565:+PAADGSVA_HALLMARK_GLYCOLYSISEER2.6079e-020.1668image
ENSG00000088888.16,MAVSPCPGGSVA_HALLMARK_MYC_TARGETS_V1EAG6.1643e-03-0.2018image
chr20:3867382-3873565:+PCPGGSVA_HALLMARK_MYC_TARGETS_V1EER8.2467e-03-0.1947image
ENSG00000088888.16,MAVSPRADGSVA_HALLMARK_UV_RESPONSE_DNEAG1.1460e-150.3482image
chr20:3867382-3873565:+PRADGSVA_HALLMARK_UV_RESPONSE_DNEER8.9855e-150.3377image
ENSG00000088888.16,MAVSREADGSVA_HALLMARK_APOPTOSISEAG6.1611e-040.3451image
chr20:3867382-3873565:+READGSVA_HALLMARK_APOPTOSISEER6.1611e-040.3451image
ENSG00000088888.16,MAVSSARCGSVA_HALLMARK_UV_RESPONSE_DNEAG1.3517e-030.1989image
chr20:3867382-3873565:+SARCGSVA_HALLMARK_HYPOXIAEER9.8004e-040.2044image
chr20:3867382-3873565:+SKCMGSVA_HALLMARK_HEME_METABOLISMEER2.8586e-070.2338image
ENSG00000088888.16,MAVSSKCMGSVA_HALLMARK_HEME_METABOLISMEAG2.0392e-070.2366image
chr20:3867382-3873565:+STADGSVA_HALLMARK_MYOGENESISEER1.2957e-070.2706image
ENSG00000088888.16,MAVSSTADGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.0087e-070.2729image
chr20:3858453-3858949:+STADGSVA_HALLMARK_P53_PATHWAYEER1.8190e-020.2944image
chr20:3875123-3875384:+STADGSVA_HALLMARK_KRAS_SIGNALING_UPEER5.0061e-030.2934image
chr20:3850927-3851897:+STADGSVA_HALLMARK_BILE_ACID_METABOLISMEER8.1161e-03-0.4986image
chr20:3867382-3873565:+TGCTGSVA_HALLMARK_HEME_METABOLISMEER1.2791e-03-0.2556image
ENSG00000088888.16,MAVSTGCTGSVA_HALLMARK_HEME_METABOLISMEAG1.2194e-02-0.2003image
chr20:3867382-3873565:+THCAGSVA_HALLMARK_ANDROGEN_RESPONSEEER3.4365e-170.3635image
ENSG00000088888.16,MAVSTHCAGSVA_HALLMARK_ANDROGEN_RESPONSEEAG5.4326e-180.3720image
chr20:3867382-3873565:+THYMGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER3.2969e-050.3723image
ENSG00000088888.16,MAVSTHYMGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG3.2969e-050.3723image
chr20:3867382-3873565:+UCECGSVA_HALLMARK_HYPOXIAEER1.0515e-020.1913image
ENSG00000088888.16,MAVSUCECGSVA_HALLMARK_HEME_METABOLISMEAG6.9374e-030.2017image
ENSG00000088888.16,MAVSUCSGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG6.7525e-030.3580image
chr20:3867382-3873565:+UCSGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER4.0616e-030.3781image
ENSG00000088888.16,MAVSUVMGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.3838e-040.4134image
chr20:3867382-3873565:+UVMGSVA_HALLMARK_MITOTIC_SPINDLEEER3.5406e-040.3896image


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7. Enriched editing regions and drugs for MAVS


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr20:3867382-3873565:+ACCBryostatin.1EER1.0718e-030.3613image
ENSG00000088888.16,MAVSACCBryostatin.1EAG1.3180e-030.3552image
ENSG00000088888.16,MAVSBLCAAZD6482EAG8.8363e-09-0.2812image
chr20:3867382-3873565:+BLCAKIN001.135EER8.1253e-08-0.2633image
ENSG00000088888.16,MAVSBRCAJNK.Inhibitor.VIIIEAG2.1719e-03-0.0931image
chr20:3867382-3873565:+BRCAJNK.Inhibitor.VIIIEER1.6533e-03-0.0955image
ENSG00000088888.16,MAVSCESCAxitinibEAG8.3472e-040.1906image
chr20:3867382-3873565:+CESCAxitinibEER5.5727e-040.1972image
ENSG00000088888.16,MAVSCHOLAZD6482EAG1.7233e-03-0.5106image
chr20:3867382-3873565:+CHOLAZD6482EER1.7233e-03-0.5106image
ENSG00000088888.16,MAVSCOADBMS.708163EAG2.6241e-07-0.3039image
chr20:3867382-3873565:+COADBMS.708163EER1.4776e-07-0.3099image
chr20:3867382-3873565:+DLBCAS601245EER1.6349e-030.4426image
ENSG00000088888.16,MAVSDLBCAS601245EAG2.4353e-030.4276image
ENSG00000088888.16,MAVSESCAGNF.2EAG5.1651e-05-0.3134image
chr20:3867382-3873565:+ESCACGP.60474EER7.8288e-06-0.3441image
ENSG00000088888.16,MAVSGBMBI.2536EAG7.9271e-040.2572image
chr20:3867382-3873565:+GBMBIBW2992EER4.0373e-04-0.2707image
ENSG00000088888.16,MAVSHNSCDMOGEAG1.8992e-05-0.1904image
chr20:3867382-3873565:+HNSCDMOGEER3.2954e-05-0.1849image
chr20:3867382-3873565:+KICHBMS.536924EER7.4240e-030.3291image
ENSG00000088888.16,MAVSKICHBMS.536924EAG7.4240e-030.3291image
chr20:3867382-3873565:+KIRCBryostatin.1EER4.5145e-070.2541image
chr20:3875123-3875384:+KIRCLapatinibEER4.5101e-03-0.5121image
ENSG00000088888.16,MAVSKIRCBryostatin.1EAG7.3731e-100.3072image
ENSG00000088888.16,MAVSKIRPDMOGEAG1.4416e-07-0.3039image
chr20:3867382-3873565:+KIRPDMOGEER1.3383e-07-0.3046image
ENSG00000088888.16,MAVSLAMLElesclomolEAG7.6026e-04-0.2720image
chr20:3867382-3873565:+LAMLElesclomolEER6.3416e-04-0.2758image
chr20:3867382-3873565:+LGGBMS.708163EER1.5192e-21-0.3982image
ENSG00000088888.16,MAVSLGGBMS.708163EAG7.2481e-21-0.3919image
ENSG00000088888.16,MAVSLIHCIPA.3EAG6.3858e-040.1774image
chr20:3867382-3873565:+LIHCIPA.3EER2.5182e-050.2183image
ENSG00000088888.16,MAVSLUADBMS.509744EAG1.4957e-06-0.2104image
chr20:3867382-3873565:+LUADBMS.509744EER3.3927e-07-0.2229image
ENSG00000088888.16,MAVSLUSCGDC.0449EAG9.0757e-04-0.1482image
chr20:3867382-3873565:+LUSCGDC.0449EER3.2538e-04-0.1606image
ENSG00000088888.16,MAVSMESOABT.263EAG3.6252e-020.2331image
chr20:3867382-3873565:+MESOABT.263EER1.5511e-020.2681image
ENSG00000088888.16,MAVSOVEmbelinEAG7.7860e-080.3080image
chr20:3867382-3873565:+OVEmbelinEER3.4171e-100.3568image
chr20:3850927-3851897:+OVAZD7762EER1.9023e-03-0.5356image
chr20:3867382-3873565:+PAADAZD6482EER2.1524e-020.1757image
ENSG00000088888.16,MAVSPAADAZD6482EAG2.5719e-020.1706image
ENSG00000088888.16,MAVSPCPGCCT007093EAG6.0174e-08-0.3874image
chr20:3867382-3873565:+PCPGCCT007093EER4.4354e-08-0.3910image
chr20:3867382-3873565:+PRADCEP.701EER4.0797e-110.2899image
ENSG00000088888.16,MAVSPRADCEP.701EAG5.3155e-110.2882image
ENSG00000088888.16,MAVSREADBexaroteneEAG4.3502e-02-0.2076image
chr20:3867382-3873565:+READBexaroteneEER4.3502e-02-0.2076image
chr20:3867382-3873565:+SARCElesclomolEER5.0385e-060.2803image
ENSG00000088888.16,MAVSSARCElesclomolEAG1.7780e-050.2642image
chr20:3867382-3873565:+SKCMEmbelinEER2.2076e-08-0.2542image
ENSG00000088888.16,MAVSSKCMEmbelinEAG4.2208e-10-0.2826image
chr20:3867382-3873565:+STADBexaroteneEER2.9963e-10-0.3203image
chr20:3875123-3875384:+STADAZ628EER1.3646e-03-0.3325image
chr20:3858453-3858949:+STADAICAREER1.2297e-02-0.3113image
chr20:3850927-3851897:+STADBleomycinEER4.0973e-02-0.3958image
ENSG00000088888.16,MAVSSTADBexaroteneEAG5.1993e-10-0.3162image
chr20:3867382-3873565:+TGCTGefitinibEER4.4137e-02-0.1614image
chr20:3867382-3873565:+THCAAMG.706EER5.1138e-170.3616image
ENSG00000088888.16,MAVSTHCAAMG.706EAG1.4507e-170.3675image
ENSG00000088888.16,MAVSTHYMAxitinibEAG4.7098e-070.4441image
chr20:3867382-3873565:+THYMAxitinibEER4.7098e-070.4441image
ENSG00000088888.16,MAVSUCECAMG.706EAG2.2288e-030.2278image
chr20:3867382-3873565:+UCECAMG.706EER1.3067e-020.1857image
chr20:3867382-3873565:+UCSMetforminEER5.3866e-03-0.3671image
ENSG00000088888.16,MAVSUCSMetforminEAG3.6785e-03-0.3819image
ENSG00000088888.16,MAVSUVMErlotinibEAG4.4548e-040.3835image
chr20:3867382-3873565:+UVMErlotinibEER4.3093e-040.3844image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType