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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: KIAA1143 (ImmuneEditome ID:57456)

1. Gene summary of enriched editing regions for KIAA1143

check button Gene summary
Gene informationGene symbol

KIAA1143

Gene ID

57456

GeneSynonyms-
GeneCytomap

3p21.31

GeneTypeprotein-coding
GeneDescriptionuncharacterized protein KIAA1143
GeneModificationdate20230329
UniprotIDQ96AT1
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr3:44749083-44750127:-ENST00000484437.1ENSG00000163807.5KIAA1143ncRNA_intronicAluY,AluJrchr3:44749083-44750127:-.alignment


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2. Tumor-specific enriched editing regions for KIAA1143


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr3:44749083-44750127:-BRCAEER3.5492e-10image
ENSG00000163807.5,KIAA1143BRCAEAG3.5492e-10image
chr3:44749083-44750127:-COADEER7.9449e-13image
ENSG00000163807.5,KIAA1143COADEAG7.9449e-13image
chr3:44749083-44750127:-HNSCEER9.4738e-18image
ENSG00000163807.5,KIAA1143HNSCEAG9.4738e-18image
chr3:44749083-44750127:-KICHEER5.5581e-13image
ENSG00000163807.5,KIAA1143KICHEAG5.5581e-13image
chr3:44749083-44750127:-KIRCEER4.9967e-06image
ENSG00000163807.5,KIAA1143KIRCEAG4.9967e-06image
chr3:44749083-44750127:-KIRPEER5.1600e-05image
ENSG00000163807.5,KIAA1143KIRPEAG5.1600e-05image
chr3:44749083-44750127:-LIHCEER3.6695e-02image
ENSG00000163807.5,KIAA1143LIHCEAG3.6695e-02image
chr3:44749083-44750127:-LUADEER5.4276e-05image
ENSG00000163807.5,KIAA1143LUADEAG5.4276e-05image
chr3:44749083-44750127:-LUSCEER3.2453e-09image
ENSG00000163807.5,KIAA1143LUSCEAG3.2453e-09image
chr3:44749083-44750127:-PRADEER9.2467e-05image
ENSG00000163807.5,KIAA1143PRADEAG9.2467e-05image
chr3:44749083-44750127:-STADEER2.4082e-05image
ENSG00000163807.5,KIAA1143STADEAG2.4082e-05image
chr3:44749083-44750127:-THCAEER2.2986e-07image
ENSG00000163807.5,KIAA1143THCAEAG2.2986e-07image
chr3:44749083-44750127:-UCECEER4.5287e-08image
ENSG00000163807.5,KIAA1143UCECEAG4.5287e-08image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr3:44749083-44750127:-KIRCPathEER3.9741e-032.4925e-030.1316image
ENSG00000163807.5,KIAA1143KIRCPathEAG3.9741e-032.4925e-030.1316image
chr3:44749083-44750127:-KIRPPathEER1.8669e-025.2171e-030.1741image
ENSG00000163807.5,KIAA1143KIRPPathEAG1.8669e-025.2171e-030.1741image
ENSG00000163807.5,KIAA1143THCAPathEAG2.1040e-063.0715e-040.1603image
chr3:44749083-44750127:-THCAPathEER2.1040e-063.0715e-040.1603image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for KIAA1143


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr3:44749083-44750127:-BLCAEERENSG00000160710,ADAR0.47555.7598e-204.3339e-170.4034imageNNADARMacrophages_M1GSVA_HALLMARK_MITOTIC_SPINDLE
chr3:44749083-44750127:-BLCAEERENSG00000204267,TAP20.46307.8787e-194.3826e-170.4034imageNNTAP2T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr3:44749083-44750127:-BLCAEERENSG00000123609,NMI0.46061.2572e-188.3851e-240.4741imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr3:44749083-44750127:-BLCAEERENSG00000156587,UBE2L60.44991.2411e-173.0489e-210.4490imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr3:44749083-44750127:-BLCAEERENSG00000168394,TAP10.43651.6895e-164.8438e-170.4029imageNNTAP1T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr3:44749083-44750127:-BLCAEERENSG00000140853,NLRC50.43461.9756e-168.2026e-190.4232imageNNNLRC5T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr3:44749083-44750127:-BLCAEERENSG00000206337,HCP50.43292.2132e-163.2650e-200.4384imageNNHCP5T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr3:44749083-44750127:-BLCAEERENSG00000138496,PARP90.42102.6557e-151.5726e-170.4086imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr3:44749083-44750127:-BLCAEERENSG00000115415,STAT10.41488.8460e-151.5703e-170.4086imageNNSTAT1T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr3:44749083-44750127:-BLCAEERENSG00000261338,RP11-378A13.1-0.39461.0783e-133.8920e-17-0.4040imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_SPERMATOGENESIS

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4. Enriched editing regions and immune related splicing for KIAA1143


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr3:44749083-44750127:-
BLCAEERIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.60551.3280e-349.2320e-39-0.5893imageNNPRKCSHMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
ENSG00000163807.5,KIAA1143
BLCAEAGIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.60551.3426e-349.2320e-39-0.5893imageNADAR;AUH;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PRPF8;PTBP1;RBFOX2;RBM10;RBM27;RBM47;RNF219;SAFB2;SF3B4;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184PRKCSHMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr3:44749083-44750127:-
CESCEERIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.44242.0561e-101.7689e-17-0.4627imageNNPRKCSHMacrophages_M0GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
ENSG00000163807.5,KIAA1143
CESCEAGIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.44241.4659e-101.7689e-17-0.4627imageNADAR;AUH;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PRPF8;PTBP1;RBFOX2;RBM10;RBM27;RBM47;RNF219;SAFB2;SF3B4;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184PRKCSHMacrophages_M0GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr3:44749083-44750127:-
KIRPEERMEXENSG00000126456.11chr1949663420:49663514:49664442:49664673:49664673:49664866:49665630:496657050.31961.2514e-053.2799e-160.4591imageNNIRF3Macrophages_M1GSVA_HALLMARK_PANCREAS_BETA_CELLS
ENSG00000163807.5,KIAA1143
KIRPEAGA3ENSG00000104177.13chr1548153791:48153893:48151873:48151942:48151873:481522840.27391.0003e-048.8834e-140.4414imageNADAR;BUD13;CNBP;CSTF2T;DDX54;DGCR8;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;MBNL2;MOV10;NOP56;NOP58;NUMA1;PRPF8;PTBP1;RBFOX2;RBM10;RBM47;RNF219;SF3B4;SRSF1;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;UPF1;ZNF184NAMacrophages_M1GSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSE
chr3:44749083-44750127:-
KIRPEERMEXENSG00000126456.11chr1949663420:49663514:49664442:49664673:49664673:49664846:49665671:496657800.31901.2790e-052.3482e-160.4611imageNNIRF3Macrophages_M1GSVA_HALLMARK_PANCREAS_BETA_CELLS
chr3:44749083-44750127:-
KIRPEERMEXENSG00000126456.11chr1949663420:49663514:49664442:49664673:49664673:49664950:49665630:496657050.31911.2970e-053.1765e-160.4593imageNNIRF3Macrophages_M1GSVA_HALLMARK_PANCREAS_BETA_CELLS
chr3:44749083-44750127:-
KIRPEERMEXENSG00000126456.11chr1949663420:49663514:49664442:49664673:49664673:49664901:49665630:496657050.31911.3011e-053.3789e-160.4589imageNNIRF3Macrophages_M1GSVA_HALLMARK_PANCREAS_BETA_CELLS
ENSG00000163807.5,KIAA1143
KIRPEAGMEXENSG00000126456.11chr1949663420:49663514:49664442:49664673:49664673:49664846:49665483:496656130.30174.4087e-059.3802e-180.4798imageNADAR;AUH;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LIN28;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PRPF8;PTBP1;RBFOX2;RBM10;RBM27;RNF219;SAFB2;SF3B4;SLTM;SND1;SRSF1;SRSF3;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184IRF3Macrophages_M1GSVA_HALLMARK_PANCREAS_BETA_CELLS

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5. Enriched editing regions and immune infiltration for KIAA1143


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr3:44749083-44750127:-ACCEERT_cells_CD4_memory_resting6.6156e-03-0.3110image
ENSG00000163807.5,KIAA1143ACCEAGT_cells_CD4_memory_resting6.6156e-03-0.3110image
chr3:44749083-44750127:-BLCAEERMacrophages_M12.4129e-110.3258image
ENSG00000163807.5,KIAA1143BLCAEAGMacrophages_M12.4129e-110.3258image
chr3:44749083-44750127:-BRCAEERMacrophages_M11.5609e-050.1312image
ENSG00000163807.5,KIAA1143BRCAEAGMacrophages_M11.5609e-050.1312image
chr3:44749083-44750127:-CESCEERMacrophages_M01.0845e-06-0.2758image
ENSG00000163807.5,KIAA1143CESCEAGMacrophages_M01.0845e-06-0.2758image
chr3:44749083-44750127:-COADEERMacrophages_M19.1169e-040.2026image
ENSG00000163807.5,KIAA1143COADEAGMacrophages_M19.1169e-040.2026image
chr3:44749083-44750127:-DLBCEERT_cells_CD4_memory_activated4.5599e-030.4153image
ENSG00000163807.5,KIAA1143DLBCEAGT_cells_CD4_memory_activated4.5599e-030.4153image
chr3:44749083-44750127:-ESCAEERT_cells_regulatory_(Tregs)1.0218e-02-0.2019image
ENSG00000163807.5,KIAA1143ESCAEAGT_cells_regulatory_(Tregs)1.0218e-02-0.2019image
chr3:44749083-44750127:-GBMEERMacrophages_M01.8384e-05-0.3249image
ENSG00000163807.5,KIAA1143GBMEAGMacrophages_M01.8384e-05-0.3249image
chr3:44749083-44750127:-HNSCEERMacrophages_M16.2216e-030.1228image
ENSG00000163807.5,KIAA1143HNSCEAGMacrophages_M16.2216e-030.1228image
chr3:44749083-44750127:-KICHEERT_cells_gamma_delta3.4857e-020.2642image
ENSG00000163807.5,KIAA1143KICHEAGT_cells_gamma_delta3.4857e-020.2642image
chr3:44749083-44750127:-KIRCEERMacrophages_M26.9693e-06-0.2286image
ENSG00000163807.5,KIAA1143KIRCEAGMacrophages_M26.9693e-06-0.2286image
chr3:44749083-44750127:-KIRPEERMacrophages_M12.1108e-040.2182image
ENSG00000163807.5,KIAA1143KIRPEAGMacrophages_M12.1108e-040.2182image
chr3:44749083-44750127:-LGGEERMacrophages_M09.9261e-04-0.1428image
ENSG00000163807.5,KIAA1143LGGEAGMacrophages_M09.9261e-04-0.1428image
chr3:44749083-44750127:-LIHCEERMacrophages_M18.0131e-040.1774image
ENSG00000163807.5,KIAA1143LIHCEAGMacrophages_M18.0131e-040.1774image
chr3:44749083-44750127:-LUADEERT_cells_CD4_memory_activated1.7346e-050.1901image
ENSG00000163807.5,KIAA1143LUADEAGT_cells_CD4_memory_activated1.7346e-050.1901image
chr3:44749083-44750127:-LUSCEERT_cells_CD4_memory_activated2.7245e-050.1870image
ENSG00000163807.5,KIAA1143LUSCEAGT_cells_CD4_memory_activated2.7245e-050.1870image
chr3:44749083-44750127:-MESOEERMast_cells_resting2.7069e-02-0.2442image
ENSG00000163807.5,KIAA1143MESOEAGMast_cells_resting2.7069e-02-0.2442image
chr3:44749083-44750127:-OVEERT_cells_CD83.7004e-040.2070image
ENSG00000163807.5,KIAA1143OVEAGT_cells_CD83.7004e-040.2070image
chr3:44749083-44750127:-PAADEERT_cells_CD4_memory_activated8.8690e-03-0.1962image
ENSG00000163807.5,KIAA1143PAADEAGT_cells_CD4_memory_activated8.8690e-03-0.1962image
chr3:44749083-44750127:-PCPGEERT_cells_gamma_delta1.4117e-020.1812image
ENSG00000163807.5,KIAA1143PCPGEAGT_cells_gamma_delta1.4117e-020.1812image
chr3:44749083-44750127:-PRADEERT_cells_regulatory_(Tregs)5.3050e-060.2022image
ENSG00000163807.5,KIAA1143PRADEAGT_cells_regulatory_(Tregs)5.3050e-060.2022image
chr3:44749083-44750127:-SARCEERB_cells_naive2.4247e-02-0.1411image
ENSG00000163807.5,KIAA1143SARCEAGB_cells_naive2.4247e-02-0.1411image
chr3:44749083-44750127:-SKCMEERT_cells_CD88.1810e-070.2268image
ENSG00000163807.5,KIAA1143SKCMEAGT_cells_CD88.1810e-070.2268image
chr3:44749083-44750127:-STADEEREosinophils1.6076e-050.2219image
ENSG00000163807.5,KIAA1143STADEAGEosinophils1.6076e-050.2219image
chr3:44749083-44750127:-TGCTEERMacrophages_M23.7887e-13-0.5393image
ENSG00000163807.5,KIAA1143TGCTEAGMacrophages_M23.7887e-13-0.5393image
chr3:44749083-44750127:-THCAEERT_cells_regulatory_(Tregs)2.6445e-060.2074image
ENSG00000163807.5,KIAA1143THCAEAGT_cells_regulatory_(Tregs)2.6445e-060.2074image
chr3:44749083-44750127:-THYMEERMacrophages_M11.1480e-090.5277image
ENSG00000163807.5,KIAA1143THYMEAGMacrophages_M11.1480e-090.5277image
chr3:44749083-44750127:-UCECEERDendritic_cells_resting3.6641e-02-0.1590image
ENSG00000163807.5,KIAA1143UCECEAGDendritic_cells_resting3.6641e-02-0.1590image
chr3:44749083-44750127:-UCSEEREosinophils2.3039e-02-0.3034image
ENSG00000163807.5,KIAA1143UCSEAGEosinophils2.3039e-02-0.3034image
chr3:44749083-44750127:-UVMEERT_cells_CD4_memory_resting2.1183e-04-0.4152image
ENSG00000163807.5,KIAA1143UVMEAGT_cells_CD4_memory_resting2.1183e-04-0.4152image


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6. Enriched editing regions and immune gene sets for KIAA1143


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr3:44749083-44750127:-BLCAEER2.7948e-090.29167.1063e-060.22241.6751e-080.27742.9890e-050.2071image
ENSG00000163807.5,KIAA1143BLCAEAG2.7948e-090.29167.1063e-060.22241.6751e-080.27742.9890e-050.2071image
chr3:44749083-44750127:-THYMEER3.5695e-05-0.37381.7318e-06-0.42729.5322e-030.23981.2129e-050.3940image
ENSG00000163807.5,KIAA1143THYMEAG3.5695e-05-0.37381.7318e-06-0.42729.5322e-030.23981.2129e-050.3940image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000163807.5,KIAA1143ACCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG1.6110e-020.2771image
chr3:44749083-44750127:-ACCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER1.6110e-020.2771image
ENSG00000163807.5,KIAA1143BLCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG9.3406e-180.4112image
chr3:44749083-44750127:-BLCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER9.3406e-180.4112image
ENSG00000163807.5,KIAA1143BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.6810e-170.2537image
chr3:44749083-44750127:-BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.6810e-170.2537image
chr3:44749083-44750127:-CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.8146e-120.3903image
ENSG00000163807.5,KIAA1143CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.8146e-120.3903image
chr3:44749083-44750127:-CHOLGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER8.0591e-03-0.4407image
ENSG00000163807.5,KIAA1143CHOLGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG8.0591e-03-0.4407image
chr3:44749083-44750127:-COADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER9.5384e-070.2957image
ENSG00000163807.5,KIAA1143COADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG9.5384e-070.2957image
ENSG00000163807.5,KIAA1143DLBCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG9.2543e-030.3838image
chr3:44749083-44750127:-DLBCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER9.2543e-030.3838image
chr3:44749083-44750127:-ESCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER2.4143e-02-0.1777image
ENSG00000163807.5,KIAA1143ESCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG2.4143e-02-0.1777image
chr3:44749083-44750127:-GBMGSVA_HALLMARK_BILE_ACID_METABOLISMEER3.6877e-060.3494image
ENSG00000163807.5,KIAA1143GBMGSVA_HALLMARK_BILE_ACID_METABOLISMEAG3.6877e-060.3494image
chr3:44749083-44750127:-HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.5875e-090.2582image
ENSG00000163807.5,KIAA1143HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG5.5875e-090.2582image
chr3:44749083-44750127:-KICHGSVA_HALLMARK_APICAL_SURFACEEER6.6527e-04-0.4143image
ENSG00000163807.5,KIAA1143KICHGSVA_HALLMARK_APICAL_SURFACEEAG6.6527e-04-0.4143image
chr3:44749083-44750127:-KIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.2437e-050.2086image
ENSG00000163807.5,KIAA1143KIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.2437e-050.2086image
ENSG00000163807.5,KIAA1143KIRPGSVA_HALLMARK_KRAS_SIGNALING_DNEAG5.5261e-030.1642image
chr3:44749083-44750127:-KIRPGSVA_HALLMARK_KRAS_SIGNALING_DNEER5.5261e-030.1642image
ENSG00000163807.5,KIAA1143LAMLGSVA_HALLMARK_PEROXISOMEEAG1.1595e-02-0.2307image
chr3:44749083-44750127:-LAMLGSVA_HALLMARK_PEROXISOMEEER1.1595e-02-0.2307image
chr3:44749083-44750127:-LGGGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER6.6116e-06-0.1945image
ENSG00000163807.5,KIAA1143LGGGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG6.6116e-06-0.1945image
ENSG00000163807.5,KIAA1143LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG6.2615e-060.2375image
chr3:44749083-44750127:-LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEER6.2615e-060.2375image
chr3:44749083-44750127:-LUADGSVA_HALLMARK_DNA_REPAIREER6.7881e-080.2375image
ENSG00000163807.5,KIAA1143LUADGSVA_HALLMARK_DNA_REPAIREAG6.7881e-080.2375image
ENSG00000163807.5,KIAA1143LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.1931e-100.2772image
chr3:44749083-44750127:-LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.1931e-100.2772image
chr3:44749083-44750127:-MESOGSVA_HALLMARK_BILE_ACID_METABOLISMEER2.3864e-02-0.2494image
ENSG00000163807.5,KIAA1143MESOGSVA_HALLMARK_BILE_ACID_METABOLISMEAG2.3864e-02-0.2494image
chr3:44749083-44750127:-OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER6.2094e-100.3518image
ENSG00000163807.5,KIAA1143OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.2094e-100.3518image
chr3:44749083-44750127:-PAADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.4964e-040.2812image
ENSG00000163807.5,KIAA1143PAADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.4964e-040.2812image
chr3:44749083-44750127:-PRADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.3059e-200.4001image
ENSG00000163807.5,KIAA1143PRADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.3059e-200.4001image
chr3:44749083-44750127:-READGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.9857e-040.3476image
ENSG00000163807.5,KIAA1143READGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG5.9857e-040.3476image
chr3:44749083-44750127:-SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER8.3551e-050.2438image
ENSG00000163807.5,KIAA1143SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG8.3551e-050.2438image
ENSG00000163807.5,KIAA1143SKCMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.8546e-060.2195image
chr3:44749083-44750127:-SKCMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.8546e-060.2195image
chr3:44749083-44750127:-STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.1112e-060.2497image
ENSG00000163807.5,KIAA1143STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.1112e-060.2497image
chr3:44749083-44750127:-TGCTGSVA_HALLMARK_ANGIOGENESISEER8.3573e-10-0.4665image
ENSG00000163807.5,KIAA1143TGCTGSVA_HALLMARK_ANGIOGENESISEAG8.3573e-10-0.4665image
chr3:44749083-44750127:-THCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER4.9460e-130.3145image
ENSG00000163807.5,KIAA1143THCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG4.9460e-130.3145image
chr3:44749083-44750127:-THYMGSVA_HALLMARK_E2F_TARGETSEER3.2934e-11-0.5668image
ENSG00000163807.5,KIAA1143THYMGSVA_HALLMARK_E2F_TARGETSEAG3.2934e-11-0.5668image
ENSG00000163807.5,KIAA1143UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.0500e-030.2328image
chr3:44749083-44750127:-UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.0500e-030.2328image
chr3:44749083-44750127:-UCSGSVA_HALLMARK_GLYCOLYSISEER5.6171e-030.3654image
ENSG00000163807.5,KIAA1143UCSGSVA_HALLMARK_GLYCOLYSISEAG5.6171e-030.3654image
ENSG00000163807.5,KIAA1143UVMGSVA_HALLMARK_APICAL_SURFACEEAG2.3792e-070.5550image
chr3:44749083-44750127:-UVMGSVA_HALLMARK_APICAL_SURFACEEER2.3792e-070.5550image


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7. Enriched editing regions and drugs for KIAA1143


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000163807.5,KIAA1143ACCLFM.A13EAG3.1012e-030.3371image
chr3:44749083-44750127:-ACCLFM.A13EER3.1012e-030.3371image
ENSG00000163807.5,KIAA1143BLCAAxitinibEAG6.6377e-130.3491image
chr3:44749083-44750127:-BLCAAxitinibEER6.6377e-130.3491image
chr3:44749083-44750127:-BRCAImatinibEER2.3923e-100.1914image
ENSG00000163807.5,KIAA1143BRCAImatinibEAG2.3923e-100.1914image
ENSG00000163807.5,KIAA1143CESCABT.888EAG1.5692e-04-0.2155image
chr3:44749083-44750127:-CESCABT.888EER1.5692e-04-0.2155image
ENSG00000163807.5,KIAA1143CHOLMG.132EAG4.9122e-030.4647image
chr3:44749083-44750127:-CHOLMG.132EER4.9122e-030.4647image
chr3:44749083-44750127:-COADCI.1040EER3.9026e-04-0.2163image
ENSG00000163807.5,KIAA1143COADCI.1040EAG3.9026e-04-0.2163image
ENSG00000163807.5,KIAA1143DLBCAZD.2281EAG3.4341e-03-0.4271image
chr3:44749083-44750127:-DLBCAZD.2281EER3.4341e-03-0.4271image
chr3:44749083-44750127:-ESCABleomycinEER2.4576e-020.1771image
ENSG00000163807.5,KIAA1143ESCABleomycinEAG2.4576e-020.1771image
ENSG00000163807.5,KIAA1143GBMBIBW2992EAG2.9089e-07-0.3844image
chr3:44749083-44750127:-GBMBIBW2992EER2.9089e-07-0.3844image
chr3:44749083-44750127:-HNSCFH535EER6.6087e-070.2213image
ENSG00000163807.5,KIAA1143HNSCFH535EAG6.6087e-070.2213image
ENSG00000163807.5,KIAA1143KICHLenalidomideEAG2.3933e-05-0.5018image
chr3:44749083-44750127:-KICHLenalidomideEER2.3933e-05-0.5018image
ENSG00000163807.5,KIAA1143KIRCGDC.0449EAG3.0021e-09-0.2991image
chr3:44749083-44750127:-KIRCGDC.0449EER3.0021e-09-0.2991image
chr3:44749083-44750127:-KIRPBX.795EER4.5016e-06-0.2684image
ENSG00000163807.5,KIAA1143KIRPBX.795EAG4.5016e-06-0.2684image
ENSG00000163807.5,KIAA1143LAMLBIRB.0796EAG2.1936e-02-0.2099image
chr3:44749083-44750127:-LAMLBIRB.0796EER2.1936e-02-0.2099image
ENSG00000163807.5,KIAA1143LGGDoxorubicinEAG2.2728e-050.1831image
chr3:44749083-44750127:-LGGDoxorubicinEER2.2728e-050.1831image
ENSG00000163807.5,KIAA1143LIHCIPA.3EAG1.3721e-050.2292image
chr3:44749083-44750127:-LIHCIPA.3EER1.3721e-050.2292image
chr3:44749083-44750127:-LUADCGP.60474EER1.7897e-06-0.2109image
ENSG00000163807.5,KIAA1143LUADCGP.60474EAG1.7897e-06-0.2109image
chr3:44749083-44750127:-LUSCAP.24534EER9.1912e-070.2181image
ENSG00000163807.5,KIAA1143LUSCAP.24534EAG9.1912e-070.2181image
ENSG00000163807.5,KIAA1143MESOAZD7762EAG2.3655e-020.2497image
chr3:44749083-44750127:-MESOAZD7762EER2.3655e-020.2497image
ENSG00000163807.5,KIAA1143OVImatinibEAG2.1521e-110.3787image
chr3:44749083-44750127:-OVImatinibEER2.1521e-110.3787image
ENSG00000163807.5,KIAA1143PAADBX.795EAG1.3644e-030.2389image
chr3:44749083-44750127:-PAADBX.795EER1.3644e-030.2389image
ENSG00000163807.5,KIAA1143PCPGMidostaurinEAG1.4233e-030.2341image
chr3:44749083-44750127:-PCPGMidostaurinEER1.4233e-030.2341image
chr3:44749083-44750127:-PRADJNK.Inhibitor.VIIIEER4.3498e-12-0.3034image
ENSG00000163807.5,KIAA1143PRADJNK.Inhibitor.VIIIEAG4.3498e-12-0.3034image
chr3:44749083-44750127:-READCyclopamineEER1.3452e-03-0.3277image
ENSG00000163807.5,KIAA1143READCyclopamineEAG1.3452e-03-0.3277image
ENSG00000163807.5,KIAA1143SARCAG.014699EAG4.5468e-090.3568image
chr3:44749083-44750127:-SARCAG.014699EER4.5468e-090.3568image
ENSG00000163807.5,KIAA1143SKCMAG.014699EAG1.9449e-090.2746image
chr3:44749083-44750127:-SKCMAG.014699EER1.9449e-090.2746image
chr3:44749083-44750127:-STADCHIR.99021EER1.8674e-030.1614image
ENSG00000163807.5,KIAA1143STADCHIR.99021EAG1.8674e-030.1614image
ENSG00000163807.5,KIAA1143TGCTLenalidomideEAG2.9466e-09-0.4528image
chr3:44749083-44750127:-TGCTLenalidomideEER2.9466e-09-0.4528image
ENSG00000163807.5,KIAA1143THCACI.1040EAG3.2034e-22-0.4134image
chr3:44749083-44750127:-THCACI.1040EER3.2034e-22-0.4134image
chr3:44749083-44750127:-THYMDoxorubicinEER1.0895e-130.6205image
ENSG00000163807.5,KIAA1143THYMDoxorubicinEAG1.0895e-130.6205image
chr3:44749083-44750127:-UCECGDC.0449EER9.1541e-06-0.3302image
ENSG00000163807.5,KIAA1143UCECGDC.0449EAG9.1541e-06-0.3302image
chr3:44749083-44750127:-UCSCisplatinEER2.0130e-04-0.4771image
ENSG00000163807.5,KIAA1143UCSCisplatinEAG2.0130e-04-0.4771image
chr3:44749083-44750127:-UVMCGP.60474EER2.3514e-07-0.5552image
ENSG00000163807.5,KIAA1143UVMCGP.60474EAG2.3514e-07-0.5552image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType