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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: BIRC6 (ImmuneEditome ID:57448)

1. Gene summary of enriched editing regions for BIRC6

check button Gene summary
Gene informationGene symbol

BIRC6

Gene ID

57448

GeneSynonymsAPOLLON|BRUCE
GeneCytomap

2p22.3

GeneTypeprotein-coding
GeneDescriptionbaculoviral IAP repeat-containing protein 6|BIR repeat-containing ubiquitin-conjugating enzyme|RING-type E3 ubiquitin transferase BIRC6|ubiquitin-conjugating BIR-domain enzyme apollon
GeneModificationdate20230517
UniprotIDQ9NR09;H7C3P0
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr2:32367199-32369884:+ENST00000421745.5ENSG00000115760.12BIRC6intronicAluSz,MER5B,AluSg,L2a,FLAM_C,AluSx3,AluSp,Helitron3Na_Mam,(AAAT)nchr2:32367199-32369884:+.alignment
chr2:32370999-32371589:+ENST00000421745.5ENSG00000115760.12BIRC6intronicAluSx3,AluJb,L1ME4achr2:32370999-32371589:+.alignment
chr2:32396792-32397011:+ENST00000466527.1ENSG00000115760.12BIRC6ncRNA_intronicAluSxchr2:32396792-32397011:+.alignment
chr2:32461203-32461452:+ENST00000421745.5ENSG00000115760.12BIRC6intronic(GT)n,AluSzchr2:32461203-32461452:+.alignment
chr2:32462679-32462926:+ENST00000421745.5ENSG00000115760.12BIRC6intronicAluSz6chr2:32462679-32462926:+.alignment
chr2:32494606-32494838:+ENST00000421745.5ENSG00000115760.12BIRC6intronicAluJochr2:32494606-32494838:+.alignment
chr2:32505927-32507391:+ENST00000421745.5ENSG00000115760.12BIRC6intronicMIRb,AluSz6,AluJochr2:32505927-32507391:+.alignment
chr2:32508873-32509403:+ENST00000421745.5ENSG00000115760.12BIRC6intronicAluSg,AluSc8chr2:32508873-32509403:+.alignment
chr2:32519517-32521791:+ENST00000421745.5ENSG00000115760.12BIRC6intronicL2,AluSx,AluSz,FLAM_A,A-richchr2:32519517-32521791:+.alignment
chr2:32534205-32534627:+ENST00000471232.4ENSG00000115760.12BIRC6ncRNA_intronicL1MEg,AluSq2,AluSx1chr2:32534205-32534627:+.alignment
chr2:32552697-32553628:+ENST00000471232.4ENSG00000115760.12BIRC6ncRNA_intronicAluSx1,AluSp,(A)n,AluSz6chr2:32552697-32553628:+.alignment
chr2:32555414-32555910:+ENST00000471232.4ENSG00000115760.12BIRC6ncRNA_intronicAluJb,AluSgchr2:32555414-32555910:+.alignment


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2. Tumor-specific enriched editing regions for BIRC6


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr2:32396792-32397011:+BRCAPathEER1.3708e-029.7392e-03-0.5167image
ENSG00000115760.12,BIRC6LUADPathEAG3.2115e-022.0591e-020.2912image
chr2:32552697-32553628:+STADPathEER5.6783e-031.0372e-030.2773image
ENSG00000115760.12,BIRC6UCECCliEAG2.3093e-059.6692e-030.4145image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for BIRC6


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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4. Enriched editing regions and immune related splicing for BIRC6


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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5. Enriched editing regions and immune infiltration for BIRC6


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr2:32396792-32397011:+BRCAEERNK_cells_resting4.1019e-020.4291image
ENSG00000115760.12,BIRC6BRCAEAGT_cells_CD4_memory_resting4.1534e-02-0.1797image
chr2:32367199-32369884:+ESCAEERNeutrophils8.5456e-030.4261image
chr2:32494606-32494838:+ESCAEERT_cells_regulatory_(Tregs)8.9265e-03-0.5684image
chr2:32519517-32521791:+ESCAEERMacrophages_M21.2463e-020.2782image
chr2:32552697-32553628:+ESCAEERT_cells_CD4_memory_activated1.9159e-020.2631image
ENSG00000115760.12,BIRC6ESCAEAGPlasma_cells1.7878e-030.2694image
chr2:32367199-32369884:+LAMLEERNK_cells_resting5.6160e-040.3008image
ENSG00000115760.12,BIRC6LAMLEAGMast_cells_resting1.2563e-02-0.2120image
ENSG00000115760.12,BIRC6LUSCEAGT_cells_gamma_delta1.6313e-030.4150image
chr2:32396792-32397011:+OVEEREosinophils2.2720e-020.5063image
chr2:32552697-32553628:+OVEERT_cells_regulatory_(Tregs)1.8956e-020.3073image
ENSG00000115760.12,BIRC6OVEAGDendritic_cells_resting6.9528e-030.2442image
chr2:32505927-32507391:+PCPGEERDendritic_cells_resting2.3674e-020.2683image
ENSG00000115760.12,BIRC6PCPGEAGDendritic_cells_resting1.5881e-020.2814image
chr2:32367199-32369884:+STADEERNK_cells_resting1.6510e-020.3311image
chr2:32494606-32494838:+STADEERT_cells_CD4_memory_activated1.6393e-030.3748image
chr2:32508873-32509403:+STADEEREosinophils2.4141e-020.4685image
chr2:32519517-32521791:+STADEERT_cells_CD4_memory_activated9.7096e-030.2669image
chr2:32552697-32553628:+STADEERNK_cells_resting2.1752e-020.1945image
ENSG00000115760.12,BIRC6STADEAGT_cells_CD4_memory_activated4.0357e-020.1368image
ENSG00000115760.12,BIRC6TGCTEAGT_cells_gamma_delta3.5065e-02-0.3574image
ENSG00000115760.12,BIRC6UCECEAGDendritic_cells_activated8.7754e-030.5127image


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6. Enriched editing regions and immune gene sets for BIRC6


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000115760.12,BIRC6BLCAGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG3.9405e-040.5808image
ENSG00000115760.12,BIRC6BRCAGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG4.4302e-060.3917image
ENSG00000115760.12,BIRC6COADGSVA_HALLMARK_COMPLEMENTEAG2.7130e-020.4705image
chr2:32367199-32369884:+ESCAGSVA_HALLMARK_P53_PATHWAYEER2.2640e-020.3739image
chr2:32519517-32521791:+ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.6628e-02-0.2341image
chr2:32494606-32494838:+ESCAGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER1.1856e-020.5507image
chr2:32552697-32553628:+ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER4.8882e-020.2224image
ENSG00000115760.12,BIRC6ESCAGSVA_HALLMARK_MYC_TARGETS_V2EAG3.6778e-020.1820image
chr2:32552697-32553628:+LAMLGSVA_HALLMARK_BILE_ACID_METABOLISMEER2.8606e-02-0.4214image
chr2:32462679-32462926:+LAMLGSVA_HALLMARK_FATTY_ACID_METABOLISMEER6.6024e-030.4634image
chr2:32461203-32461452:+LAMLGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER2.4740e-020.3845image
ENSG00000115760.12,BIRC6LGGGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG6.6741e-030.3283image
ENSG00000115760.12,BIRC6LUADGSVA_HALLMARK_MYC_TARGETS_V1EAG1.5555e-030.4029image
ENSG00000115760.12,BIRC6LUSCGSVA_HALLMARK_MYOGENESISEAG1.0278e-02-0.3433image
ENSG00000115760.12,BIRC6OVGSVA_HALLMARK_UV_RESPONSE_DNEAG1.5125e-02-0.2204image
chr2:32505927-32507391:+PCPGGSVA_HALLMARK_MYOGENESISEER2.4824e-020.2662image
ENSG00000115760.12,BIRC6PCPGGSVA_HALLMARK_MYOGENESISEAG3.5063e-020.2471image
ENSG00000115760.12,BIRC6PRADGSVA_HALLMARK_ADIPOGENESISEAG1.8910e-030.6125image
ENSG00000115760.12,BIRC6STADGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.7642e-030.1986image
chr2:32367199-32369884:+STADGSVA_HALLMARK_HYPOXIAEER6.9998e-030.3696image
chr2:32519517-32521791:+STADGSVA_HALLMARK_SPERMATOGENESISEER9.6566e-030.2671image
chr2:32370999-32371589:+STADGSVA_HALLMARK_PROTEIN_SECRETIONEER2.7852e-030.2364image
chr2:32552697-32553628:+STADGSVA_HALLMARK_HYPOXIAEER5.7464e-040.2884image
chr2:32494606-32494838:+STADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER8.8001e-030.3154image
ENSG00000115760.12,BIRC6THCAGSVA_HALLMARK_ANDROGEN_RESPONSEEAG5.4875e-030.4795image
ENSG00000115760.12,BIRC6UCECGSVA_HALLMARK_KRAS_SIGNALING_DNEAG3.9151e-020.4150image


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7. Enriched editing regions and drugs for BIRC6


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000115760.12,BIRC6BLCAJNK.9LEAG8.5472e-03-0.4503image
chr2:32396792-32397011:+BRCAGSK269962AEER3.5636e-020.4400image
ENSG00000115760.12,BIRC6BRCAA.443654EAG1.2990e-03-0.2802image
chr2:32367199-32369884:+ESCAAS601245EER3.0921e-02-0.3553image
chr2:32494606-32494838:+ESCAMethotrexateEER1.1733e-020.5514image
chr2:32552697-32553628:+ESCADoxorubicinEER4.0485e-03-0.3199image
chr2:32462679-32462926:+LAMLABT.263EER4.3971e-030.4832image
chr2:32461203-32461452:+LAMLGemcitabineEER2.8218e-02-0.3764image
ENSG00000115760.12,BIRC6LAMLAZD7762EAG2.1227e-020.1960image
chr2:32367199-32369884:+LAMLIPA.3EER2.7443e-02-0.1949image
ENSG00000115760.12,BIRC6LGGMidostaurinEAG1.4279e-030.3819image
ENSG00000115760.12,BIRC6LUADCytarabineEAG7.2938e-04-0.4276image
ENSG00000115760.12,BIRC6LUSCLFM.A13EAG3.1216e-040.4682image
chr2:32552697-32553628:+OVAMG.706EER5.6879e-04-0.4389image
ENSG00000115760.12,BIRC6OVAZD6482EAG4.4099e-040.3159image
chr2:32505927-32507391:+PCPGLapatinibEER3.1500e-02-0.2555image
ENSG00000115760.12,BIRC6PCPGBIBW2992EAG4.1361e-020.2394image
ENSG00000115760.12,BIRC6PRADFH535EAG4.3522e-04-0.6728image
ENSG00000115760.12,BIRC6STADAICAREAG2.4705e-020.1497image
chr2:32508873-32509403:+STADBryostatin.1EER1.8788e-020.4857image
chr2:32370999-32371589:+STADJNJ.26854165EER2.0016e-040.2917image
chr2:32552697-32553628:+STADCyclopamineEER3.4343e-03-0.2483image
chr2:32494606-32494838:+STADCCT007093EER5.7426e-030.3316image
ENSG00000115760.12,BIRC6TGCTJNK.Inhibitor.VIIIEAG3.4902e-02-0.3577image
ENSG00000115760.12,BIRC6THCAAxitinibEAG3.2852e-030.5038image
ENSG00000115760.12,BIRC6UCECAZD8055EAG1.2702e-020.4910image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType