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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: AS3MT (ImmuneEditome ID:57412)

1. Gene summary of enriched editing regions for AS3MT

check button Gene summary
Gene informationGene symbol

AS3MT

Gene ID

57412

GeneSynonymsCYT19
GeneCytomap

10q24.32

GeneTypeprotein-coding
GeneDescriptionarsenite methyltransferase|S-adenosyl-L-methionine:arsenic(III) methyltransferase|S-adenosylmethionine:arsenic (III) methyltransferase|arsenic (+3 oxidation state) methyltransferase|methylarsonite methyltransferase|methyltransferase cyt19
GeneModificationdate20230515
UniprotIDQ9HBK9
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr10:102900763-102901518:+ENST00000615257.1ENSG00000214435.6AS3MTsplicingAluSx,AluYchr10:102900763-102901518:+.alignment


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2. Tumor-specific enriched editing regions for AS3MT


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr10:102900763-102901518:+BRCAEER8.8702e-03image
chr10:102900763-102901518:+KICHEER6.1322e-12image
ENSG00000214435.6,AS3MTKICHEAG6.1322e-12image
chr10:102900763-102901518:+LIHCEER9.5111e-03image
ENSG00000214435.6,AS3MTLIHCEAG1.5340e-03image
ENSG00000214435.6,AS3MTLUSCEAG4.2479e-02image
chr10:102900763-102901518:+PRADEER4.2967e-02image
ENSG00000214435.6,AS3MTPRADEAG4.0519e-02image
chr10:102900763-102901518:+THCAEER5.3544e-03image
ENSG00000214435.6,AS3MTTHCAEAG6.0919e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for AS3MT


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr10:102900763-102901518:+GBMEERENSG00000006747,SCIN0.38305.1496e-049.3565e-080.4179imageNNSCINMonocytesGSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr10:102900763-102901518:+GBMEERENSG00000152315,KCNK130.38465.2463e-049.3506e-080.4179imageNNNAMonocytesGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr10:102900763-102901518:+GBMEERENSG00000026297,RNASET20.37268.6456e-043.4754e-070.4005imageNNNAMonocytesGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr10:102900763-102901518:+KICHEERENSG00000143374,TARS20.52434.1024e-025.2420e-060.5425imageNNNAMacrophages_M1GSVA_HALLMARK_DNA_REPAIR
chr10:102900763-102901518:+THCAEERENSG00000131504,DIAPH10.39427.7538e-151.9975e-180.4052imageNNNAB_cells_naiveGSVA_HALLMARK_MITOTIC_SPINDLE
chr10:102900763-102901518:+KIRCEERENSG00000160710,ADAR0.46876.1127e-176.5720e-210.4603imageNNADARMacrophages_M1GSVA_HALLMARK_MITOTIC_SPINDLE
chr10:102900763-102901518:+UCECEERENSG00000188313,PLSCR10.44204.5385e-041.9412e-070.4375imageNNPLSCR1Dendritic_cells_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr10:102900763-102901518:+UCECEERENSG00000115267,IFIH10.41851.3122e-031.9222e-060.4036imageNNIFIH1Dendritic_cells_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr10:102900763-102901518:+UCECEERENSG00000185885,IFITM10.37614.8163e-032.9426e-080.4629imageNNIFITM1Dendritic_cells_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr10:102900763-102901518:+UCECEERENSG00000163565,IFI160.35897.7762e-032.8902e-070.4319imageNNIFI16Macrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE

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4. Enriched editing regions and immune related splicing for AS3MT


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000214435.6,AS3MT
KIRPEAGA3ENSG00000160445.6chr9128739930:128740119:128735333:128735397:128735333:1287354310.10632.5288e-029.9401e-120.4117imageNADAR;AUH;BCCIP;BUD13;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FBL;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;LIN28;LIN28A;LIN28B;MOV10;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RBFOX2;RBM10;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;U2AF1;U2AF2;UPF1;XRN2;ZNF184NANK_cells_restingGSVA_HALLMARK_DNA_REPAIR
chr10:102900763-102901518:+
KIRPEERA3ENSG00000160445.6chr9128739930:128740119:128735333:128735397:128735333:1287354310.10632.3759e-029.9401e-120.4117imageNNNANK_cells_restingGSVA_HALLMARK_DNA_REPAIR
chr10:102900763-102901518:+
LIHCEERIRENSG00000136305.7chr1424305095:24308830:24310648:24310718-0.30911.1846e-083.0676e-13-0.4224imageNNCIDEBT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
ENSG00000214435.6,AS3MT
LIHCEAGIRENSG00000136305.7chr1424305095:24308830:24310648:24310718-0.30901.0429e-084.1117e-13-0.4203imageNAUH;BCCIP;BUD13;CSTF2T;EIF4A3;FUS;HNRNPA1;HNRNPC;HNRNPK;HNRNPU;IGF2BP1;IGF2BP3;LIN28B;PCBP2;PRPF8;RBFOX2;SF3A3;SF3B4;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TIA1;U2AF1;UPF1CIDEBT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
chr10:102900763-102901518:+
TGCTEERESENSG00000141698.12chr1741835202:41835272:41835587:41835682:41835858:418359570.34491.8612e-026.5891e-060.4184imageNNNAMacrophages_M2GSVA_HALLMARK_GLYCOLYSIS
chr10:102900763-102901518:+
TGCTEERA3ENSG00000234769.4chr1618601:18764:17956:18055:17956:18243-0.35141.4622e-022.9701e-05-0.4085imageNNNAMacrophages_M2GSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr10:102900763-102901518:+
TGCTEERA3ENSG00000075303.8chr787858630:87858751:87856291:87856351:87856291:878563890.30331.1448e-023.2869e-050.4573imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr10:102900763-102901518:+
TGCTEERA5ENSG00000168824.10chr44387603:4387758:4385472:4386643:4385472:43871730.33351.9555e-023.3691e-050.4246imageNNNAMacrophages_M2GSVA_HALLMARK_MYOGENESIS
ENSG00000214435.6,AS3MT
TGCTEAGIRENSG00000115085.9chr297733296:97734712:97735249:977354560.30953.3524e-021.0642e-040.4014imageNADAR;BUD13;CSTF2T;DGCR8;DKC1;EIF4A3;ELAVL1;EWSR1;FBL;FUS;HNRNPL;IGF2BP3;LIN28A;NOP56;NOP58;PRPF8;RBFOX2;RBM10;SF3B4;SRSF1;SRSF3;SRSF7;TAF15;U2AF1;UPF1ZAP70B_cells_naiveGSVA_HALLMARK_NOTCH_SIGNALING
chr10:102900763-102901518:+
TGCTEERIRENSG00000125826.15chr20420870:421615:422126:422238-0.25693.3110e-028.0342e-05-0.4014imageNNRBCK1T_cells_CD8GSVA_HALLMARK_MYC_TARGETS_V2

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5. Enriched editing regions and immune infiltration for AS3MT


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr10:102900763-102901518:+ACCEERMacrophages_M22.7195e-020.2640image
ENSG00000214435.6,AS3MTACCEAGMacrophages_M22.7652e-020.2633image
chr10:102900763-102901518:+BLCAEERMacrophages_M18.5277e-030.2000image
ENSG00000214435.6,AS3MTBLCAEAGMacrophages_M11.4529e-020.1861image
chr10:102900763-102901518:+BRCAEERT_cells_CD4_memory_activated8.4558e-030.0909image
ENSG00000214435.6,AS3MTBRCAEAGT_cells_CD4_memory_activated2.6681e-020.0765image
chr10:102900763-102901518:+CESCEERT_cells_follicular_helper3.2942e-030.2433image
ENSG00000214435.6,AS3MTCESCEAGT_cells_follicular_helper4.2908e-030.2367image
chr10:102900763-102901518:+GBMEERMonocytes9.4123e-040.2665image
ENSG00000214435.6,AS3MTGBMEAGMonocytes7.8215e-040.2705image
chr10:102900763-102901518:+HNSCEERT_cells_CD84.1942e-02-0.1753image
ENSG00000214435.6,AS3MTHNSCEAGT_cells_CD83.3087e-02-0.1836image
chr10:102900763-102901518:+KICHEEREosinophils3.3651e-020.2702image
ENSG00000214435.6,AS3MTKICHEAGEosinophils3.3651e-020.2702image
chr10:102900763-102901518:+KIRCEERMacrophages_M19.5187e-040.1706image
ENSG00000214435.6,AS3MTKIRCEAGMacrophages_M17.7791e-040.1735image
chr10:102900763-102901518:+KIRPEERT_cells_CD4_memory_activated2.7074e-030.1867image
ENSG00000214435.6,AS3MTKIRPEAGT_cells_CD4_memory_activated2.7074e-030.1867image
chr10:102900763-102901518:+LGGEERDendritic_cells_resting1.6466e-040.1744image
ENSG00000214435.6,AS3MTLGGEAGDendritic_cells_resting1.1718e-040.1779image
chr10:102900763-102901518:+LIHCEERMacrophages_M15.5588e-070.2584image
ENSG00000214435.6,AS3MTLIHCEAGMacrophages_M12.0121e-050.2212image
chr10:102900763-102901518:+LUADEERT_cells_CD81.5717e-030.1752image
ENSG00000214435.6,AS3MTLUADEAGT_cells_CD83.3915e-030.1616image
chr10:102900763-102901518:+LUSCEERNK_cells_resting6.6070e-030.1600image
chr10:102900763-102901518:+OVEERT_cells_CD87.2250e-030.1819image
ENSG00000214435.6,AS3MTOVEAGT_cells_CD86.2097e-030.1848image
chr10:102900763-102901518:+PAADEERDendritic_cells_resting3.3822e-020.2361image
ENSG00000214435.6,AS3MTPAADEAGDendritic_cells_resting3.3673e-020.2363image
chr10:102900763-102901518:+PCPGEERMast_cells_activated4.0752e-02-0.1625image
ENSG00000214435.6,AS3MTPCPGEAGMast_cells_activated4.5897e-02-0.1586image
ENSG00000214435.6,AS3MTPRADEAGT_cells_CD4_memory_resting2.5357e-020.1166image
chr10:102900763-102901518:+SARCEERMacrophages_M22.0258e-020.1812image
ENSG00000214435.6,AS3MTSARCEAGMacrophages_M22.2044e-020.1782image
chr10:102900763-102901518:+TGCTEERMacrophages_M21.9881e-03-0.2904image
ENSG00000214435.6,AS3MTTGCTEAGMacrophages_M26.2912e-03-0.2579image
chr10:102900763-102901518:+THCAEERB_cells_memory2.0996e-03-0.1479image
ENSG00000214435.6,AS3MTTHCAEAGB_cells_memory2.6481e-03-0.1446image
chr10:102900763-102901518:+THYMEERT_cells_regulatory_(Tregs)2.1839e-04-0.3823image
ENSG00000214435.6,AS3MTTHYMEAGT_cells_regulatory_(Tregs)6.6888e-04-0.3539image
chr10:102900763-102901518:+UCECEERDendritic_cells_activated7.9790e-040.2906image
ENSG00000214435.6,AS3MTUCECEAGDendritic_cells_activated1.1676e-030.2806image
chr10:102900763-102901518:+UVMEERDendritic_cells_activated2.6956e-02-0.3098image


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6. Enriched editing regions and immune gene sets for AS3MT


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000214435.6,AS3MTACCGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG4.9930e-030.3320image
chr10:102900763-102901518:+ACCGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEER6.2585e-030.3237image
ENSG00000214435.6,AS3MTBLCAGSVA_HALLMARK_KRAS_SIGNALING_DNEAG4.5949e-040.2643image
chr10:102900763-102901518:+BLCAGSVA_HALLMARK_KRAS_SIGNALING_DNEER3.9457e-040.2672image
chr10:102900763-102901518:+BRCAGSVA_HALLMARK_PROTEIN_SECRETIONEER2.4710e-080.1911image
ENSG00000214435.6,AS3MTBRCAGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.4338e-080.1942image
chr10:102900763-102901518:+CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.7389e-030.2341image
ENSG00000214435.6,AS3MTCESCGSVA_HALLMARK_PROTEIN_SECRETIONEAG6.5197e-030.2257image
ENSG00000214435.6,AS3MTCHOLGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG3.9333e-020.3847image
chr10:102900763-102901518:+CHOLGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER4.8513e-020.3695image
chr10:102900763-102901518:+ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.1925e-030.3796image
ENSG00000214435.6,AS3MTESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.0872e-030.3464image
chr10:102900763-102901518:+GBMGSVA_HALLMARK_KRAS_SIGNALING_UPEER6.9541e-060.3567image
ENSG00000214435.6,AS3MTGBMGSVA_HALLMARK_KRAS_SIGNALING_UPEAG6.9221e-060.3567image
chr10:102900763-102901518:+HNSCGSVA_HALLMARK_HYPOXIAEER7.6027e-030.2288image
ENSG00000214435.6,AS3MTHNSCGSVA_HALLMARK_HYPOXIAEAG6.2836e-030.2341image
chr10:102900763-102901518:+KIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER7.6164e-090.2939image
ENSG00000214435.6,AS3MTKIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.0055e-080.2916image
ENSG00000214435.6,AS3MTKIRPGSVA_HALLMARK_KRAS_SIGNALING_UPEAG2.0837e-030.1915image
chr10:102900763-102901518:+KIRPGSVA_HALLMARK_KRAS_SIGNALING_UPEER2.0837e-030.1915image
chr10:102900763-102901518:+LGGGSVA_HALLMARK_MYC_TARGETS_V2EER1.3424e-04-0.1767image
ENSG00000214435.6,AS3MTLGGGSVA_HALLMARK_MYC_TARGETS_V2EAG1.8734e-04-0.1726image
ENSG00000214435.6,AS3MTLIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.4983e-130.3738image
chr10:102900763-102901518:+LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.5235e-120.3590image
ENSG00000214435.6,AS3MTLUADGSVA_HALLMARK_ANDROGEN_RESPONSEEAG2.8765e-030.1643image
chr10:102900763-102901518:+LUADGSVA_HALLMARK_ANDROGEN_RESPONSEEER5.9748e-040.1900image
ENSG00000214435.6,AS3MTLUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.3231e-050.2389image
chr10:102900763-102901518:+LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.0968e-060.2681image
chr10:102900763-102901518:+MESOGSVA_HALLMARK_IL2_STAT5_SIGNALINGEER1.9341e-02-0.3331image
ENSG00000214435.6,AS3MTMESOGSVA_HALLMARK_IL2_STAT5_SIGNALINGEAG1.9802e-02-0.3319image
ENSG00000214435.6,AS3MTOVGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG2.9417e-040.2429image
chr10:102900763-102901518:+OVGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER6.9034e-050.2668image
ENSG00000214435.6,AS3MTPAADGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG4.2875e-020.2256image
ENSG00000214435.6,AS3MTPCPGGSVA_HALLMARK_PROTEIN_SECRETIONEAG7.7029e-030.2106image
chr10:102900763-102901518:+PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEER7.7759e-030.2104image
chr10:102900763-102901518:+PRADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER4.4859e-040.1820image
ENSG00000214435.6,AS3MTPRADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG1.4990e-030.1649image
chr10:102900763-102901518:+SARCGSVA_HALLMARK_GLYCOLYSISEER3.9189e-030.2241image
ENSG00000214435.6,AS3MTSARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.5674e-030.2108image
ENSG00000214435.6,AS3MTSKCMGSVA_HALLMARK_SPERMATOGENESISEAG1.3455e-02-0.2007image
chr10:102900763-102901518:+SKCMGSVA_HALLMARK_SPERMATOGENESISEER1.1768e-02-0.2045image
ENSG00000214435.6,AS3MTSTADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.6595e-030.2449image
chr10:102900763-102901518:+STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.7318e-030.2454image
chr10:102900763-102901518:+TGCTGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER6.8852e-03-0.2551image
ENSG00000214435.6,AS3MTTGCTGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG1.0309e-02-0.2426image
chr10:102900763-102901518:+THCAGSVA_HALLMARK_ANDROGEN_RESPONSEEER4.9338e-160.3778image
ENSG00000214435.6,AS3MTTHCAGSVA_HALLMARK_ANDROGEN_RESPONSEEAG9.6578e-150.3618image
ENSG00000214435.6,AS3MTTHYMGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG1.6971e-030.3281image
chr10:102900763-102901518:+THYMGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER8.0009e-040.3491image
ENSG00000214435.6,AS3MTUCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.5847e-030.2733image
chr10:102900763-102901518:+UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER7.7083e-040.2914image
ENSG00000214435.6,AS3MTUCSGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG3.5816e-040.4763image
chr10:102900763-102901518:+UCSGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEER4.3289e-040.4704image


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7. Enriched editing regions and drugs for AS3MT


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr10:102900763-102901518:+ACCCI.1040EER4.2793e-03-0.3375image
ENSG00000214435.6,AS3MTACCCI.1040EAG3.4914e-03-0.3446image
ENSG00000214435.6,AS3MTBLCAElesclomolEAG2.4761e-040.2760image
chr10:102900763-102901518:+BLCAElesclomolEER1.1133e-040.2904image
chr10:102900763-102901518:+BRCAGW843682XEER1.4060e-040.1311image
ENSG00000214435.6,AS3MTBRCAGW843682XEAG4.3740e-040.1211image
ENSG00000214435.6,AS3MTCESCAMG.706EAG9.0185e-030.2177image
chr10:102900763-102901518:+CESCAMG.706EER9.7853e-030.2154image
chr10:102900763-102901518:+CHOLEHT.1864EER1.7299e-030.5562image
ENSG00000214435.6,AS3MTCHOLEHT.1864EAG1.8648e-030.5530image
chr10:102900763-102901518:+ESCAFH535EER4.4908e-020.2405image
ENSG00000214435.6,AS3MTESCAFH535EAG4.6338e-020.2373image
ENSG00000214435.6,AS3MTGBMDMOGEAG3.4313e-06-0.3676image
chr10:102900763-102901518:+GBMDMOGEER6.5584e-06-0.3576image
chr10:102900763-102901518:+HNSCCyclopamineEER4.2534e-050.3459image
ENSG00000214435.6,AS3MTHNSCCyclopamineEAG3.9083e-050.3474image
ENSG00000214435.6,AS3MTKICHFH535EAG3.6558e-03-0.3638image
chr10:102900763-102901518:+KICHFH535EER3.6558e-03-0.3638image
chr10:102900763-102901518:+KIRCEmbelinEER2.5492e-09-0.3027image
ENSG00000214435.6,AS3MTKIRCEmbelinEAG1.9777e-09-0.3047image
chr10:102900763-102901518:+KIRPCMKEER2.2923e-040.2283image
ENSG00000214435.6,AS3MTKIRPCMKEAG2.2923e-040.2283image
ENSG00000214435.6,AS3MTLGGGSK.650394EAG1.0123e-040.1795image
chr10:102900763-102901518:+LGGCamptothecinEER2.8349e-050.1934image
chr10:102900763-102901518:+LIHCEtoposideEER3.8198e-100.3202image
ENSG00000214435.6,AS3MTLIHCEtoposideEAG5.3693e-100.3176image
chr10:102900763-102901518:+LUADGemcitabineEER2.4176e-04-0.2029image
ENSG00000214435.6,AS3MTLUADGemcitabineEAG2.6842e-04-0.2002image
chr10:102900763-102901518:+LUSCCyclopamineEER3.9384e-02-0.1219image
ENSG00000214435.6,AS3MTMESOKU.55933EAG7.4041e-030.3780image
chr10:102900763-102901518:+MESOKU.55933EER4.6776e-030.3975image
chr10:102900763-102901518:+OVCI.1040EER2.6315e-05-0.2812image
ENSG00000214435.6,AS3MTOVCI.1040EAG4.5868e-05-0.2724image
ENSG00000214435.6,AS3MTPAADGNF.2EAG3.7760e-020.2388image
chr10:102900763-102901518:+PAADGNF.2EER3.5598e-020.2415image
chr10:102900763-102901518:+PCPGAZD.0530EER3.3305e-040.2819image
ENSG00000214435.6,AS3MTPCPGAZD.0530EAG1.3949e-040.2985image
ENSG00000214435.6,AS3MTPRADBryostatin.1EAG8.3566e-040.1734image
chr10:102900763-102901518:+PRADBryostatin.1EER1.1436e-030.1689image
ENSG00000214435.6,AS3MTSARCCMKEAG1.9319e-040.2863image
chr10:102900763-102901518:+SARCCMKEER2.1314e-040.2853image
chr10:102900763-102901518:+SKCMCI.1040EER1.4856e-03-0.2564image
ENSG00000214435.6,AS3MTSKCMCI.1040EAG1.8930e-03-0.2508image
ENSG00000214435.6,AS3MTSTADBicalutamideEAG5.8847e-03-0.2385image
chr10:102900763-102901518:+STADBicalutamideEER6.1488e-03-0.2382image
chr10:102900763-102901518:+TGCTAUY922EER1.7687e-050.3952image
ENSG00000214435.6,AS3MTTGCTAUY922EAG6.1124e-050.3710image
chr10:102900763-102901518:+THCAAMG.706EER6.9484e-130.3371image
ENSG00000214435.6,AS3MTTHCAAMG.706EAG3.3887e-120.3273image
ENSG00000214435.6,AS3MTTHYMKIN001.135EAG4.3743e-05-0.4190image
chr10:102900763-102901518:+THYMKIN001.135EER2.9724e-06-0.4723image
chr10:102900763-102901518:+UCECAMG.706EER8.7235e-040.2885image
ENSG00000214435.6,AS3MTUCECAMG.706EAG9.3575e-040.2858image
ENSG00000214435.6,AS3MTUCSEHT.1864EAG3.1445e-060.5959image
chr10:102900763-102901518:+UCSEHT.1864EER3.4755e-060.5938image
chr10:102900763-102901518:+UVMCGP.60474EER3.5440e-03-0.4010image
ENSG00000214435.6,AS3MTUVMCGP.60474EAG3.6906e-03-0.3994image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType