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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: PSMB2 (ImmuneEditome ID:5690)

1. Gene summary of enriched editing regions for PSMB2

check button Gene summary
Gene informationGene symbol

PSMB2

Gene ID

5690

GeneSynonymsHC7-I
GeneCytomap

1p34.3

GeneTypeprotein-coding
GeneDescriptionproteasome subunit beta type-2|macropain subunit C7-I|multicatalytic endopeptidase complex subunit C7-1|multicatalytic endopeptidase complex subunit C7-I|proteasome (prosome, macropain) subunit, beta type, 2|proteasome beta 2 subunit|proteasome component C7-I|proteasome subunit beta 2|proteasome subunit beta4|proteasome subunit, beta type, 2|testicular tissue protein Li 152
GeneModificationdate20230518
UniprotIDP49721;A0A087WVV1
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr1:35599827-35602817:-ENST00000630477.1ENSG00000126067.10PSMB2ncRNA_exonicAluJr,AluSc,L2,AluJb,AluSx,L1ME4b,MER5A,MIR,L1MD3chr1:35599827-35602817:-.alignment


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2. Tumor-specific enriched editing regions for PSMB2


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr1:35599827-35602817:-BRCAEER4.6318e-20image
ENSG00000126067.10,PSMB2BRCAEAG4.2950e-20image
chr1:35599827-35602817:-COADEER4.7826e-07image
ENSG00000126067.10,PSMB2COADEAG4.7389e-07image
chr1:35599827-35602817:-HNSCEER8.9186e-09image
ENSG00000126067.10,PSMB2HNSCEAG8.9186e-09image
chr1:35599827-35602817:-KIRCEER6.8787e-11image
ENSG00000126067.10,PSMB2KIRCEAG6.8787e-11image
chr1:35599827-35602817:-KIRPEER8.9148e-03image
ENSG00000126067.10,PSMB2KIRPEAG9.0135e-03image
chr1:35599827-35602817:-LIHCEER1.4088e-03image
ENSG00000126067.10,PSMB2LIHCEAG1.4088e-03image
chr1:35599827-35602817:-LUADEER3.7770e-11image
ENSG00000126067.10,PSMB2LUADEAG3.7770e-11image
chr1:35599827-35602817:-LUSCEER1.8415e-03image
ENSG00000126067.10,PSMB2LUSCEAG1.8415e-03image
chr1:35599827-35602817:-THCAEER3.1753e-05image
ENSG00000126067.10,PSMB2THCAEAG3.1753e-05image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000126067.10,PSMB2KIRCPathEAG2.0829e-041.0280e-050.1900image
chr1:35599827-35602817:-KIRCPathEER2.0829e-041.0280e-050.1900image
chr1:35599827-35602817:-LIHCPathEER5.4976e-037.3096e-03-0.1432image
ENSG00000126067.10,PSMB2LIHCPathEAG5.4976e-037.3096e-03-0.1432image
ENSG00000126067.10,PSMB2OVCliEAG5.0509e-031.7361e-030.1612image
chr1:35599827-35602817:-OVCliEER5.0651e-031.7423e-030.1612image
ENSG00000126067.10,PSMB2READPathEAG1.4084e-021.4539e-03-0.2528image
chr1:35599827-35602817:-READPathEER1.4084e-021.4539e-03-0.2528image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for PSMB2


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr1:35599827-35602817:-BLCAEERENSG00000134470,IL15RA0.46781.4144e-194.2744e-200.4342imageNNIL15RAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr1:35599827-35602817:-BLCAEERENSG00000204267,TAP20.46562.8334e-191.5250e-220.4590imageNNTAP2T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr1:35599827-35602817:-BLCAEERENSG00000156587,UBE2L60.46078.6454e-198.3537e-230.4615imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr1:35599827-35602817:-BLCAEERENSG00000068079,IFI350.45939.3888e-198.9657e-210.4412imageNNIFI35T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr1:35599827-35602817:-BLCAEERENSG00000059378,PARP120.45083.0196e-184.7548e-210.4441imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr1:35599827-35602817:-BLCAEERENSG00000204642,HLA-F0.44521.4699e-171.9366e-190.4272imageNNHLA-FT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr1:35599827-35602817:-BLCAEERENSG00000240065,PSMB90.44402.0391e-175.5256e-200.4330imageNNPSMB9T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr1:35599827-35602817:-BLCAEERENSG00000025708,TYMP0.44162.2960e-172.9618e-170.4026imageNNTYMPT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr1:35599827-35602817:-BLCAEERENSG00000125347,IRF10.43747.5511e-173.1326e-190.4249imageNNIRF1T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr1:35599827-35602817:-BLCAEERENSG00000168394,TAP10.43838.0327e-173.6107e-220.4553imageNNTAP1T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE

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4. Enriched editing regions and immune related splicing for PSMB2


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000126067.10,PSMB2
BLCAEAGESENSG00000083457.7chr173720306:3720402:3723287:3723383:3723687:37237440.43387.4782e-158.3291e-220.4522imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28B;LSM11;MBNL1;MOV10;MSI1;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;SF3A3;SF3B4;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;U2AF1;U2AF2;UPF1;WTAP;XRN2;YTHDF1;ZNF184ITGAET_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr1:35599827-35602817:-
BLCAEERIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.55696.2406e-284.4379e-32-0.5404imageNNPRKCSHMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr1:35599827-35602817:-
BLCAEERESENSG00000083457.7chr173720306:3720402:3723287:3723383:3723687:37237440.43385.6037e-158.3291e-220.4522imageNNITGAET_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
ENSG00000126067.10,PSMB2
BLCAEAGIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.55696.1946e-284.4379e-32-0.5404imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL1;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;RTCB;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184PRKCSHMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr1:35599827-35602817:-
CESCEERIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.55143.3965e-193.2122e-26-0.5574imageNNPRKCSHMacrophages_M0GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
ENSG00000126067.10,PSMB2
CESCEAGIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.55143.4534e-193.2122e-26-0.5574imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL1;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;RTCB;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184PRKCSHMacrophages_M0GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr1:35599827-35602817:-
CESCEERESENSG00000083457.7chr173720306:3720402:3723287:3723383:3723687:37237440.46161.2730e-113.4016e-170.4583imageNNITGAET_cells_CD8GSVA_HALLMARK_ALLOGRAFT_REJECTION
ENSG00000126067.10,PSMB2
CESCEAGESENSG00000083457.7chr173720306:3720402:3723287:3723383:3723687:37237440.46161.0578e-113.4016e-170.4583imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28B;LSM11;MBNL1;MOV10;MSI1;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;SF3A3;SF3B4;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;U2AF1;U2AF2;UPF1;WTAP;XRN2;YTHDF1;ZNF184ITGAET_cells_CD8GSVA_HALLMARK_ALLOGRAFT_REJECTION
chr1:35599827-35602817:-
CESCEERMEXENSG00000140105.13chr14100342397:100342571:100343274:100343387:100369086:100369258:100376259:1003762850.41498.4980e-099.3895e-140.4112imageNNWARSMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
ENSG00000126067.10,PSMB2
CESCEAGMEXENSG00000140105.13chr14100342397:100342571:100343274:100343387:100369086:100369258:100376259:1003762850.41495.1381e-099.3895e-140.4112imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;RTCB;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184WARSMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE

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5. Enriched editing regions and immune infiltration for PSMB2


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr1:35599827-35602817:-BLCAEERT_cells_CD4_memory_activated4.5384e-170.4004image
ENSG00000126067.10,PSMB2BLCAEAGT_cells_CD4_memory_activated4.5384e-170.4004image
chr1:35599827-35602817:-BRCAEERMacrophages_M13.7392e-120.2090image
ENSG00000126067.10,PSMB2BRCAEAGMacrophages_M14.4505e-120.2083image
chr1:35599827-35602817:-CESCEERT_cells_CD82.4339e-060.2665image
ENSG00000126067.10,PSMB2CESCEAGT_cells_CD82.4339e-060.2665image
chr1:35599827-35602817:-COADEERPlasma_cells6.3004e-04-0.2052image
ENSG00000126067.10,PSMB2COADEAGPlasma_cells6.2274e-04-0.2054image
chr1:35599827-35602817:-DLBCEERMacrophages_M02.1930e-020.3301image
ENSG00000126067.10,PSMB2DLBCEAGMacrophages_M02.1930e-020.3301image
chr1:35599827-35602817:-ESCAEERDendritic_cells_resting1.4267e-03-0.2493image
ENSG00000126067.10,PSMB2ESCAEAGDendritic_cells_resting1.4247e-03-0.2493image
chr1:35599827-35602817:-GBMEERMacrophages_M13.4115e-050.3148image
ENSG00000126067.10,PSMB2GBMEAGMacrophages_M13.4115e-050.3148image
chr1:35599827-35602817:-HNSCEERMacrophages_M11.2803e-130.3235image
ENSG00000126067.10,PSMB2HNSCEAGMacrophages_M11.2803e-130.3235image
chr1:35599827-35602817:-KICHEERMast_cells_resting1.3535e-020.3049image
ENSG00000126067.10,PSMB2KICHEAGMast_cells_resting1.3535e-020.3049image
chr1:35599827-35602817:-KIRCEERT_cells_gamma_delta9.5232e-090.2872image
ENSG00000126067.10,PSMB2KIRCEAGT_cells_gamma_delta9.5232e-090.2872image
chr1:35599827-35602817:-KIRPEERT_cells_gamma_delta1.3639e-020.1452image
ENSG00000126067.10,PSMB2KIRPEAGT_cells_gamma_delta1.4358e-020.1441image
chr1:35599827-35602817:-LAMLEERPlasma_cells2.2750e-020.1859image
ENSG00000126067.10,PSMB2LAMLEAGPlasma_cells2.2799e-020.1858image
chr1:35599827-35602817:-LGGEERMacrophages_M13.4917e-040.1549image
ENSG00000126067.10,PSMB2LGGEAGMacrophages_M13.4917e-040.1549image
chr1:35599827-35602817:-LIHCEERMacrophages_M12.2369e-070.2642image
ENSG00000126067.10,PSMB2LIHCEAGMacrophages_M12.2369e-070.2642image
chr1:35599827-35602817:-LUADEERT_cells_CD4_memory_activated3.9346e-070.2217image
ENSG00000126067.10,PSMB2LUADEAGT_cells_CD4_memory_activated3.9346e-070.2217image
chr1:35599827-35602817:-LUSCEERT_cells_CD81.9094e-120.3086image
ENSG00000126067.10,PSMB2LUSCEAGT_cells_CD81.9094e-120.3086image
chr1:35599827-35602817:-MESOEERT_cells_CD84.4583e-050.4348image
ENSG00000126067.10,PSMB2MESOEAGT_cells_CD84.4583e-050.4348image
chr1:35599827-35602817:-OVEERT_cells_CD88.5633e-060.2572image
ENSG00000126067.10,PSMB2OVEAGT_cells_CD88.5633e-060.2572image
chr1:35599827-35602817:-PAADEERB_cells_naive1.8423e-02-0.1765image
ENSG00000126067.10,PSMB2PAADEAGB_cells_naive1.8423e-02-0.1765image
chr1:35599827-35602817:-PCPGEERMacrophages_M15.3181e-040.2536image
ENSG00000126067.10,PSMB2PCPGEAGMacrophages_M15.3181e-040.2536image
chr1:35599827-35602817:-PRADEERB_cells_naive2.5658e-04-0.1630image
ENSG00000126067.10,PSMB2PRADEAGB_cells_naive2.5658e-04-0.1630image
chr1:35599827-35602817:-SARCEERMacrophages_M16.5822e-040.2111image
ENSG00000126067.10,PSMB2SARCEAGMacrophages_M16.5822e-040.2111image
chr1:35599827-35602817:-SKCMEERT_cells_CD88.8166e-120.3076image
ENSG00000126067.10,PSMB2SKCMEAGT_cells_CD88.8166e-120.3076image
chr1:35599827-35602817:-STADEERT_cells_CD4_memory_activated7.0337e-070.2542image
ENSG00000126067.10,PSMB2STADEAGT_cells_CD4_memory_activated6.7496e-070.2546image
chr1:35599827-35602817:-TGCTEERMacrophages_M27.3456e-12-0.5132image
ENSG00000126067.10,PSMB2TGCTEAGMacrophages_M27.3456e-12-0.5132image
chr1:35599827-35602817:-THCAEERT_cells_regulatory_(Tregs)1.0467e-080.2514image
ENSG00000126067.10,PSMB2THCAEAGT_cells_regulatory_(Tregs)1.0467e-080.2514image
chr1:35599827-35602817:-THYMEERNK_cells_resting4.4702e-040.3181image
ENSG00000126067.10,PSMB2THYMEAGNK_cells_resting4.4702e-040.3181image
chr1:35599827-35602817:-UCECEERDendritic_cells_resting7.1569e-03-0.2021image
ENSG00000126067.10,PSMB2UCECEAGDendritic_cells_resting7.1569e-03-0.2021image
chr1:35599827-35602817:-UCSEERB_cells_naive2.2392e-05-0.5341image
ENSG00000126067.10,PSMB2UCSEAGB_cells_naive2.2392e-05-0.5341image
chr1:35599827-35602817:-UVMEERT_cells_CD4_naive5.8594e-040.3784image
ENSG00000126067.10,PSMB2UVMEAGT_cells_CD4_naive5.8594e-040.3784image


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6. Enriched editing regions and immune gene sets for PSMB2


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000126067.10,PSMB2STADEAG1.5243e-110.34084.2218e-060.23622.0365e-070.26582.0879e-050.2190image
chr1:35599827-35602817:-STADEER1.5312e-110.34084.1785e-060.23632.0350e-070.26582.1019e-050.2189image
ENSG00000126067.10,PSMB2TGCTEAG3.3959e-04-0.28321.1810e-02-0.20113.5782e-08-0.42367.4358e-07-0.3841image
chr1:35599827-35602817:-TGCTEER3.3959e-04-0.28321.1810e-02-0.20113.5782e-08-0.42367.4358e-07-0.3841image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000126067.10,PSMB2ACCGSVA_HALLMARK_NOTCH_SIGNALINGEAG8.7560e-03-0.2931image
chr1:35599827-35602817:-ACCGSVA_HALLMARK_NOTCH_SIGNALINGEER8.7560e-03-0.2931image
chr1:35599827-35602817:-BLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.3021e-210.4498image
ENSG00000126067.10,PSMB2BLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.3021e-210.4498image
ENSG00000126067.10,PSMB2BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG5.6879e-630.4782image
chr1:35599827-35602817:-BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.6206e-630.4782image
ENSG00000126067.10,PSMB2CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.3140e-270.5680image
chr1:35599827-35602817:-CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.3140e-270.5680image
ENSG00000126067.10,PSMB2CHOLGSVA_HALLMARK_COMPLEMENTEAG4.2190e-02-0.3453image
chr1:35599827-35602817:-CHOLGSVA_HALLMARK_COMPLEMENTEER4.2190e-02-0.3453image
ENSG00000126067.10,PSMB2COADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG2.2021e-04-0.2214image
chr1:35599827-35602817:-COADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER2.3600e-04-0.2204image
ENSG00000126067.10,PSMB2DLBCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG2.7036e-03-0.4235image
chr1:35599827-35602817:-DLBCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER2.7036e-03-0.4235image
ENSG00000126067.10,PSMB2ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.9951e-070.3960image
chr1:35599827-35602817:-ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.9917e-070.3960image
chr1:35599827-35602817:-GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.6400e-120.5073image
ENSG00000126067.10,PSMB2GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.6400e-120.5073image
ENSG00000126067.10,PSMB2HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.6711e-420.5579image
chr1:35599827-35602817:-HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.6711e-420.5579image
chr1:35599827-35602817:-KICHGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER1.3068e-03-0.3903image
ENSG00000126067.10,PSMB2KICHGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG1.3068e-03-0.3903image
chr1:35599827-35602817:-KIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.6779e-110.3342image
ENSG00000126067.10,PSMB2KIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.6779e-110.3342image
chr1:35599827-35602817:-KIRPGSVA_HALLMARK_PROTEIN_SECRETIONEER1.3152e-04-0.2234image
ENSG00000126067.10,PSMB2KIRPGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.3420e-04-0.2231image
chr1:35599827-35602817:-LAMLGSVA_HALLMARK_MYC_TARGETS_V1EER2.3339e-03-0.2468image
ENSG00000126067.10,PSMB2LAMLGSVA_HALLMARK_MYC_TARGETS_V1EAG2.2719e-03-0.2474image
chr1:35599827-35602817:-LGGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.5468e-120.2948image
ENSG00000126067.10,PSMB2LGGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.5468e-120.2948image
ENSG00000126067.10,PSMB2LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG3.3038e-170.4180image
chr1:35599827-35602817:-LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEER3.3038e-170.4180image
chr1:35599827-35602817:-LUADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.6599e-120.3004image
ENSG00000126067.10,PSMB2LUADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.6599e-120.3004image
ENSG00000126067.10,PSMB2LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG9.3529e-230.4205image
chr1:35599827-35602817:-LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER9.3529e-230.4205image
chr1:35599827-35602817:-MESOGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.4401e-050.4590image
ENSG00000126067.10,PSMB2MESOGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.4401e-050.4590image
ENSG00000126067.10,PSMB2OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.3433e-190.4938image
chr1:35599827-35602817:-OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.3433e-190.4938image
ENSG00000126067.10,PSMB2PAADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.1621e-060.3465image
chr1:35599827-35602817:-PAADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.1621e-060.3465image
ENSG00000126067.10,PSMB2PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG7.7990e-040.2462image
chr1:35599827-35602817:-PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER7.7990e-040.2462image
chr1:35599827-35602817:-PRADGSVA_HALLMARK_UV_RESPONSE_DNEER6.2985e-06-0.2006image
ENSG00000126067.10,PSMB2PRADGSVA_HALLMARK_UV_RESPONSE_DNEAG6.2985e-06-0.2006image
chr1:35599827-35602817:-READGSVA_HALLMARK_MITOTIC_SPINDLEEER2.3971e-04-0.3684image
ENSG00000126067.10,PSMB2READGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.3971e-04-0.3684image
ENSG00000126067.10,PSMB2SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.0533e-060.2990image
chr1:35599827-35602817:-SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.0533e-060.2990image
ENSG00000126067.10,PSMB2SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.0216e-130.3299image
chr1:35599827-35602817:-SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.0216e-130.3299image
ENSG00000126067.10,PSMB2STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.0750e-240.4913image
chr1:35599827-35602817:-STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER6.3220e-240.4912image
chr1:35599827-35602817:-TGCTGSVA_HALLMARK_GLYCOLYSISEER4.0468e-11-0.4972image
ENSG00000126067.10,PSMB2TGCTGSVA_HALLMARK_GLYCOLYSISEAG4.0468e-11-0.4972image
ENSG00000126067.10,PSMB2THCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG3.2517e-06-0.2056image
chr1:35599827-35602817:-THCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER3.2517e-06-0.2056image
chr1:35599827-35602817:-THYMGSVA_HALLMARK_MITOTIC_SPINDLEEER9.0925e-07-0.4340image
ENSG00000126067.10,PSMB2THYMGSVA_HALLMARK_MITOTIC_SPINDLEEAG9.0925e-07-0.4340image
chr1:35599827-35602817:-UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.1666e-060.3430image
ENSG00000126067.10,PSMB2UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.1666e-060.3430image
ENSG00000126067.10,PSMB2UCSGSVA_HALLMARK_GLYCOLYSISEAG4.7954e-030.3717image
chr1:35599827-35602817:-UCSGSVA_HALLMARK_GLYCOLYSISEER4.7954e-030.3717image


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7. Enriched editing regions and drugs for PSMB2


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000126067.10,PSMB2ACCABT.263EAG1.4037e-020.2754image
chr1:35599827-35602817:-ACCABT.263EER1.4037e-020.2754image
chr1:35599827-35602817:-BLCACGP.60474EER9.1707e-14-0.3586image
ENSG00000126067.10,PSMB2BLCACGP.60474EAG9.1707e-14-0.3586image
chr1:35599827-35602817:-BRCAAxitinibEER1.9124e-100.1920image
ENSG00000126067.10,PSMB2BRCAAxitinibEAG2.0517e-100.1917image
ENSG00000126067.10,PSMB2CESCCI.1040EAG1.2193e-14-0.4232image
chr1:35599827-35602817:-CESCCI.1040EER1.2193e-14-0.4232image
ENSG00000126067.10,PSMB2CHOLDocetaxelEAG3.2318e-020.3626image
chr1:35599827-35602817:-CHOLDocetaxelEER3.2318e-020.3626image
chr1:35599827-35602817:-COADGefitinibEER3.4995e-07-0.3019image
ENSG00000126067.10,PSMB2COADGefitinibEAG3.2730e-07-0.3026image
ENSG00000126067.10,PSMB2DLBCAZ628EAG4.0728e-03-0.4072image
chr1:35599827-35602817:-DLBCAZ628EER4.0728e-03-0.4072image
chr1:35599827-35602817:-ESCAABT.263EER1.1277e-030.2552image
ENSG00000126067.10,PSMB2ESCAABT.263EAG1.1268e-030.2552image
chr1:35599827-35602817:-GBMBIBW2992EER4.6818e-08-0.4073image
ENSG00000126067.10,PSMB2GBMBIBW2992EAG4.6818e-08-0.4073image
ENSG00000126067.10,PSMB2HNSCFH535EAG4.2161e-150.3416image
chr1:35599827-35602817:-HNSCFH535EER4.2161e-150.3416image
chr1:35599827-35602817:-KICHEHT.1864EER2.8020e-02-0.2726image
ENSG00000126067.10,PSMB2KICHEHT.1864EAG2.8020e-02-0.2726image
ENSG00000126067.10,PSMB2KIRCCisplatinEAG2.9635e-13-0.3604image
chr1:35599827-35602817:-KIRCCisplatinEER2.9635e-13-0.3604image
chr1:35599827-35602817:-KIRPBMS.708163EER2.0759e-050.2480image
ENSG00000126067.10,PSMB2KIRPBMS.708163EAG1.9678e-050.2486image
ENSG00000126067.10,PSMB2LAMLBMS.509744EAG4.4098e-030.2312image
chr1:35599827-35602817:-LAMLBMS.509744EER4.5658e-030.2304image
ENSG00000126067.10,PSMB2LGGErlotinibEAG1.5121e-10-0.2740image
chr1:35599827-35602817:-LGGErlotinibEER1.5121e-10-0.2740image
ENSG00000126067.10,PSMB2LIHCBleomycinEAG5.8066e-190.4423image
chr1:35599827-35602817:-LIHCBleomycinEER5.8066e-190.4423image
chr1:35599827-35602817:-LUADJNK.Inhibitor.VIIIEER3.5825e-12-0.3006image
ENSG00000126067.10,PSMB2LUADJNK.Inhibitor.VIIIEAG3.5825e-12-0.3006image
ENSG00000126067.10,PSMB2LUSCGemcitabineEAG2.4399e-08-0.2467image
chr1:35599827-35602817:-LUSCGemcitabineEER2.4399e-08-0.2467image
ENSG00000126067.10,PSMB2MESOCGP.082996EAG5.4931e-04-0.3734image
chr1:35599827-35602817:-MESOCGP.082996EER5.4931e-04-0.3734image
chr1:35599827-35602817:-OVBIBW2992EER4.2262e-10-0.3550image
ENSG00000126067.10,PSMB2OVBIBW2992EAG4.2262e-10-0.3550image
chr1:35599827-35602817:-PAADAZD6482EER3.2341e-030.2240image
ENSG00000126067.10,PSMB2PAADAZD6482EAG3.2341e-030.2240image
ENSG00000126067.10,PSMB2PCPGBMS.536924EAG7.9922e-04-0.2464image
chr1:35599827-35602817:-PCPGBMS.536924EER7.9922e-04-0.2464image
chr1:35599827-35602817:-PRADCCT007093EER3.6407e-090.2602image
ENSG00000126067.10,PSMB2PRADCCT007093EAG3.6407e-090.2602image
chr1:35599827-35602817:-READGDC.0449EER5.2518e-03-0.2842image
ENSG00000126067.10,PSMB2READGDC.0449EAG5.2518e-03-0.2842image
ENSG00000126067.10,PSMB2SARCAG.014699EAG7.8951e-070.3023image
chr1:35599827-35602817:-SARCAG.014699EER7.8951e-070.3023image
ENSG00000126067.10,PSMB2SKCMJNK.9LEAG3.9250e-09-0.2670image
chr1:35599827-35602817:-SKCMJNK.9LEER3.9250e-09-0.2670image
ENSG00000126067.10,PSMB2STADABT.263EAG1.1848e-050.2262image
chr1:35599827-35602817:-STADABT.263EER1.1802e-050.2262image
chr1:35599827-35602817:-TGCTDocetaxelEER3.7299e-080.4231image
ENSG00000126067.10,PSMB2TGCTDocetaxelEAG3.7299e-080.4231image
chr1:35599827-35602817:-THCAEmbelinEER7.5913e-150.3370image
ENSG00000126067.10,PSMB2THCAEmbelinEAG7.5913e-150.3370image
chr1:35599827-35602817:-THYMBAY.61.3606EER6.0567e-080.4736image
ENSG00000126067.10,PSMB2THYMBAY.61.3606EAG6.0567e-080.4736image
chr1:35599827-35602817:-UCECA.443654EER3.7815e-04-0.2650image
ENSG00000126067.10,PSMB2UCECA.443654EAG3.7815e-04-0.2650image
ENSG00000126067.10,PSMB2UCSAG.014699EAG2.7494e-030.3928image
chr1:35599827-35602817:-UCSAG.014699EER2.7494e-030.3928image
ENSG00000126067.10,PSMB2UVMAICAREAG8.2652e-030.2952image
chr1:35599827-35602817:-UVMAICAREER8.2652e-030.2952image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType