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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: SAR1A (ImmuneEditome ID:56681)

1. Gene summary of enriched editing regions for SAR1A

check button Gene summary
Gene informationGene symbol

SAR1A

Gene ID

56681

GeneSynonymsSAR1|SARA1|Sara|masra2
GeneCytomap

10q22.1

GeneTypeprotein-coding
GeneDescriptionGTP-binding protein SAR1a|COPII-associated small GTPase|SAR1 gene homolog A|SAR1 homolog A|SAR1a gene homolog 1
GeneModificationdate20230329
UniprotIDQ9NR31;Q5SQT9;Q5SQT8;X1WI22
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr10:70148523-70149854:-ENST00000373242.5ENSG00000079332.13SAR1AUTR3(CAAA)n,AluSg,AluJr,AluSx3chr10:70148523-70149854:-.alignment


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2. Tumor-specific enriched editing regions for SAR1A


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check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000079332.13,SAR1AOVCliEAG2.6788e-023.9184e-02-0.2203image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
ENSG00000079332.13,SAR1ALUSCEAG4.0026e-024.1806e-026.5907e+01image

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3. Enriched editing regions and immune related genes for SAR1A


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for SAR1A


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check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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5. Enriched editing regions and immune infiltration for SAR1A


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000079332.13,SAR1ABLCAEAGMast_cells_activated4.4754e-020.2823image
chr10:70148523-70149854:-BRCAEERNeutrophils6.1093e-030.1476image
ENSG00000079332.13,SAR1ABRCAEAGT_cells_follicular_helper3.0140e-02-0.1124image
ENSG00000079332.13,SAR1ACESCEAGT_cells_gamma_delta4.4903e-050.7453image
chr10:70148523-70149854:-ESCAEERB_cells_naive1.3647e-030.4948image
ENSG00000079332.13,SAR1AESCAEAGB_cells_naive7.3681e-030.2904image
chr10:70148523-70149854:-GBMEERMast_cells_activated1.2825e-020.4564image
ENSG00000079332.13,SAR1AGBMEAGMast_cells_activated1.3983e-020.4369image
ENSG00000079332.13,SAR1AHNSCEAGEosinophils9.8478e-030.3066image
ENSG00000079332.13,SAR1AKICHEAGDendritic_cells_resting2.2384e-020.4025image
ENSG00000079332.13,SAR1AKIRCEAGNK_cells_resting3.2371e-030.1925image
ENSG00000079332.13,SAR1ALAMLEAGEosinophils7.9591e-050.4508image
chr10:70148523-70149854:-LGGEERB_cells_memory2.9158e-02-0.1052image
ENSG00000079332.13,SAR1ALIHCEAGEosinophils1.6250e-030.4343image
ENSG00000079332.13,SAR1ALUADEAGNK_cells_activated6.3153e-03-0.2992image
ENSG00000079332.13,SAR1ALUSCEAGMacrophages_M01.6865e-020.3301image
ENSG00000079332.13,SAR1AMESOEAGNeutrophils3.0717e-020.3338image
ENSG00000079332.13,SAR1APCPGEAGDendritic_cells_activated1.3596e-030.2504image
ENSG00000079332.13,SAR1APRADEAGMast_cells_activated1.0830e-030.2436image
chr10:70148523-70149854:-STADEERMast_cells_resting2.8684e-02-0.2511image
ENSG00000079332.13,SAR1ASTADEAGDendritic_cells_activated1.7943e-020.2185image
ENSG00000079332.13,SAR1ATHCAEAGDendritic_cells_activated6.8204e-030.1476image
ENSG00000079332.13,SAR1ATHYMEAGMonocytes1.9238e-02-0.3642image
ENSG00000079332.13,SAR1AUCECEAGT_cells_follicular_helper2.8980e-02-0.4129image


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6. Enriched editing regions and immune gene sets for SAR1A


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000079332.13,SAR1ABLCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.3429e-030.3929image
ENSG00000079332.13,SAR1ACESCGSVA_HALLMARK_GLYCOLYSISEAG1.8554e-02-0.4866image
ENSG00000079332.13,SAR1AESCAGSVA_HALLMARK_MYC_TARGETS_V1EAG4.7762e-02-0.2166image
ENSG00000079332.13,SAR1AGBMGSVA_HALLMARK_ADIPOGENESISEAG8.0830e-030.4670image
chr10:70148523-70149854:-GBMGSVA_HALLMARK_ADIPOGENESISEER3.1104e-030.5299image
ENSG00000079332.13,SAR1AHNSCGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG4.8598e-020.2366image
ENSG00000079332.13,SAR1AKICHGSVA_HALLMARK_MYC_TARGETS_V2EAG1.8602e-02-0.4137image
ENSG00000079332.13,SAR1AKIRCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG1.1730e-02-0.1652image
ENSG00000079332.13,SAR1AKIRPGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG3.3389e-030.3113image
ENSG00000079332.13,SAR1ALAMLGSVA_HALLMARK_DNA_REPAIREAG2.7372e-020.2619image
ENSG00000079332.13,SAR1ALGGGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG8.1079e-04-0.1579image
chr10:70148523-70149854:-LGGGSVA_HALLMARK_MITOTIC_SPINDLEEER2.0626e-030.1482image
ENSG00000079332.13,SAR1ALUADGSVA_HALLMARK_DNA_REPAIREAG1.7276e-02-0.2623image
ENSG00000079332.13,SAR1ALUSCGSVA_HALLMARK_APICAL_SURFACEEAG2.5922e-020.3088image
ENSG00000079332.13,SAR1AMESOGSVA_HALLMARK_NOTCH_SIGNALINGEAG4.5862e-030.4290image
ENSG00000079332.13,SAR1AOVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.0145e-02-0.3054image
ENSG00000079332.13,SAR1APRADGSVA_HALLMARK_MYOGENESISEAG2.3109e-02-0.1707image
ENSG00000079332.13,SAR1ASARCGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG6.7930e-030.3041image
chr10:70148523-70149854:-STADGSVA_HALLMARK_IL2_STAT5_SIGNALINGEER1.3133e-020.2833image
ENSG00000079332.13,SAR1ASTADGSVA_HALLMARK_PROTEIN_SECRETIONEAG4.4709e-030.2610image
ENSG00000079332.13,SAR1ATHCAGSVA_HALLMARK_GLYCOLYSISEAG4.0753e-020.1118image
ENSG00000079332.13,SAR1ATHYMGSVA_HALLMARK_NOTCH_SIGNALINGEAG2.4261e-02-0.3514image


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7. Enriched editing regions and drugs for SAR1A


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000079332.13,SAR1ABLCAJNK.Inhibitor.VIIIEAG2.2641e-03-0.4181image
ENSG00000079332.13,SAR1ABRCAAKT.inhibitor.VIIIEAG1.0769e-02-0.1323image
chr10:70148523-70149854:-BRCAAKT.inhibitor.VIIIEER2.3702e-03-0.1636image
ENSG00000079332.13,SAR1ACESCAZD6244EAG7.3936e-03-0.5432image
ENSG00000079332.13,SAR1AESCALenalidomideEAG8.7615e-04-0.3564image
chr10:70148523-70149854:-ESCAAMG.706EER2.4277e-020.3602image
ENSG00000079332.13,SAR1AGBMKU.55933EAG1.2502e-02-0.4433image
chr10:70148523-70149854:-GBMKU.55933EER4.0729e-03-0.5171image
ENSG00000079332.13,SAR1AKIRCCGP.082996EAG5.4385e-040.2253image
ENSG00000079332.13,SAR1AKIRPAMG.706EAG4.0101e-020.2206image
ENSG00000079332.13,SAR1ALAMLGDC0941EAG1.4417e-020.2893image
ENSG00000079332.13,SAR1ALGGBMS.708163EAG4.8877e-050.1908image
chr10:70148523-70149854:-LGGBMS.708163EER3.2279e-040.1726image
ENSG00000079332.13,SAR1ALIHCAICAREAG9.8159e-03-0.3619image
ENSG00000079332.13,SAR1ALUADEmbelinEAG1.0684e-02-0.2805image
ENSG00000079332.13,SAR1ALUSCMetforminEAG1.7612e-03-0.4234image
ENSG00000079332.13,SAR1AMESOBleomycinEAG5.0140e-030.4251image
chr10:70148523-70149854:-OVImatinibEER2.8515e-02-0.2829image
ENSG00000079332.13,SAR1AOVImatinibEAG5.0623e-03-0.3315image
ENSG00000079332.13,SAR1APCPGDMOGEAG4.1402e-02-0.1609image
ENSG00000079332.13,SAR1APRADAZD.0530EAG3.4683e-020.1616image
ENSG00000079332.13,SAR1ASARCBI.2536EAG2.9682e-02-0.2464image
ENSG00000079332.13,SAR1ASKCMGSK.650394EAG2.3450e-03-0.4130image
chr10:70148523-70149854:-STADKIN001.135EER1.2539e-020.2851image
ENSG00000079332.13,SAR1ASTADMidostaurinEAG1.0011e-030.3004image
ENSG00000079332.13,SAR1ATHCAAMG.706EAG2.9066e-020.1193image
ENSG00000079332.13,SAR1ATHYMAUY922EAG1.7679e-020.3687image
ENSG00000079332.13,SAR1AUCECJNK.9LEAG3.1092e-020.4081image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType