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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: CCL28 (ImmuneEditome ID:56477)

1. Gene summary of enriched editing regions for CCL28

check button Gene summary
Gene informationGene symbol

CCL28

Gene ID

56477

GeneSynonymsCCK1|MEC|SCYA28
GeneCytomap

5p12

GeneTypeprotein-coding
GeneDescriptionC-C motif chemokine 28|CC chemokine CCL28|chemokine (C-C motif) ligand 28|mucosae-associated epithelial chemokine|small inducible cytokine A28|small inducible cytokine subfamily A (Cys-Cys), member 28
GeneModificationdate20230329
UniprotIDD6RC73;A0N0Q3;Q9NRJ3
PubMed ID

37222480

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr5:43377197-43381688:-ENST00000361115.4ENSG00000151882.10CCL28UTR3L1MC5,AluSz,AluYa5,HAL1ME,AluJr,L1MC4,AluSc,(ATAGTAC)n,AluJo,MIRb,(TTATTTA)n,AluSx1chr5:43377197-43381688:-.alignment
chr5:43377197-43381688:-ENST00000489442.4ENSG00000151882.10CCL28UTR3L1MC5,AluSz,AluYa5,HAL1ME,AluJr,L1MC4,AluSc,(ATAGTAC)n,AluJo,MIRb,(TTATTTA)n,AluSx1chr5:43377197-43381688:-.alignment
chr5:43377197-43381688:-ENST00000513525.1ENSG00000151882.10CCL28UTR3L1MC5,AluSz,AluYa5,HAL1ME,AluJr,L1MC4,AluSc,(ATAGTAC)n,AluJo,MIRb,(TTATTTA)n,AluSx1chr5:43377197-43381688:-.alignment


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2. Tumor-specific enriched editing regions for CCL28


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr5:43377197-43381688:-BRCAEER1.5398e-46image
ENSG00000151882.10,CCL28BRCAEAG1.5373e-46image
chr5:43377197-43381688:-COADEER5.2071e-26image
ENSG00000151882.10,CCL28COADEAG5.0966e-26image
chr5:43377197-43381688:-HNSCEER1.2792e-05image
ENSG00000151882.10,CCL28HNSCEAG1.2792e-05image
chr5:43377197-43381688:-KIRPEER5.7249e-03image
ENSG00000151882.10,CCL28KIRPEAG5.7249e-03image
chr5:43377197-43381688:-STADEER1.6621e-02image
ENSG00000151882.10,CCL28STADEAG1.5783e-02image
chr5:43377197-43381688:-THCAEER3.8280e-17image
ENSG00000151882.10,CCL28THCAEAG4.1204e-17image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr5:43377197-43381688:-ESCACliEER3.6755e-032.8572e-04-0.5380image
ENSG00000151882.10,CCL28ESCACliEAG3.6913e-032.8702e-04-0.5378image
ENSG00000151882.10,CCL28KIRPPathEAG7.4837e-083.8256e-090.4024image
chr5:43377197-43381688:-KIRPPathEER7.4837e-083.8256e-090.4024image
chr5:43377197-43381688:-SKCMPathEER1.4683e-022.2636e-020.1201image
ENSG00000151882.10,CCL28SKCMPathEAG1.4683e-022.2636e-020.1201image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for CCL28


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr5:43377197-43381688:-CESCEERENSG00000126264,HCST0.35968.6010e-064.2138e-110.4115imageNSRSF1HCSTT_cells_CD8GSVA_HALLMARK_ALLOGRAFT_REJECTION
chr5:43377197-43381688:-COADEERENSG00000039523,FAM65A0.25887.0054e-032.4344e-110.4426imageNADAR;HNRNPA1;PTBP1;RBM47;SRSF1;U2AF2;UPF1NAT_cells_CD4_memory_restingGSVA_HALLMARK_APICAL_SURFACE
chr5:43377197-43381688:-COADEERENSG00000239686,RP11-665C16.10.18323.0304e-023.5171e-120.4590imageNNNAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr5:43377197-43381688:-COADEERENSG00000270722,U10.19303.6044e-025.5498e-130.4738imageNNNADendritic_cells_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr5:43377197-43381688:-COADEERENSG00000111696,NT5DC30.20644.0770e-028.7500e-110.4313imageNADAR;HNRNPA1;PTBP1;RBM47;SRSF1;U2AF2;UPF1NADendritic_cells_activatedGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr5:43377197-43381688:-COADEERENSG00000262979,CTD-2047H16.20.20414.1419e-027.3571e-140.4893imageNHNRNPA1;U2AF2NAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr5:43377197-43381688:-COADEERENSG00000200665,RNU6-1188P0.10084.3695e-023.4658e-170.5418imageNNNANeutrophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr5:43377197-43381688:-COADEERENSG00000222009,BTBD190.20514.3901e-022.5346e-100.4215imageNADAR;HNRNPA1;PTBP1;SRSF1;U2AF2;UPF1NANeutrophilsGSVA_HALLMARK_PEROXISOME
chr5:43377197-43381688:-COADEERENSG00000170653,ATF70.20524.5469e-024.2180e-110.4378imageNADAR;HNRNPA1;PTBP1;RBM47;SRSF1;U2AF2;UPF1NANeutrophilsGSVA_HALLMARK_DNA_REPAIR
chr5:43377197-43381688:-THCAEERENSG00000173320,STOX2-0.47421.9413e-254.0008e-23-0.4273imageNADAR;HNRNPA1;PTBP1;SRSF1;U2AF2;UPF1NADendritic_cells_restingGSVA_HALLMARK_COAGULATION
chr5:43377197-43381688:-CESCEERENSG00000126264,HCST0.35968.6010e-064.2138e-110.4115imageNSRSF1HCSTT_cells_CD8GSVA_HALLMARK_ALLOGRAFT_REJECTION
chr5:43377197-43381688:-COADEERENSG00000039523,FAM65A0.25887.0054e-032.4344e-110.4426imageNADAR;HNRNPA1;PTBP1;RBM47;SRSF1;U2AF2;UPF1NAT_cells_CD4_memory_restingGSVA_HALLMARK_APICAL_SURFACE
chr5:43377197-43381688:-COADEERENSG00000239686,RP11-665C16.10.18323.0304e-023.5171e-120.4590imageNNNAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr5:43377197-43381688:-COADEERENSG00000270722,U10.19303.6044e-025.5498e-130.4738imageNNNADendritic_cells_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr5:43377197-43381688:-COADEERENSG00000111696,NT5DC30.20644.0770e-028.7500e-110.4313imageNADAR;HNRNPA1;PTBP1;RBM47;SRSF1;U2AF2;UPF1NADendritic_cells_activatedGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr5:43377197-43381688:-COADEERENSG00000262979,CTD-2047H16.20.20414.1419e-027.3571e-140.4893imageNHNRNPA1;U2AF2NAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr5:43377197-43381688:-COADEERENSG00000200665,RNU6-1188P0.10084.3695e-023.4658e-170.5418imageNNNANeutrophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr5:43377197-43381688:-COADEERENSG00000222009,BTBD190.20514.3901e-022.5346e-100.4215imageNADAR;HNRNPA1;PTBP1;SRSF1;U2AF2;UPF1NANeutrophilsGSVA_HALLMARK_PEROXISOME
chr5:43377197-43381688:-COADEERENSG00000170653,ATF70.20524.5469e-024.2180e-110.4378imageNADAR;HNRNPA1;PTBP1;RBM47;SRSF1;U2AF2;UPF1NANeutrophilsGSVA_HALLMARK_DNA_REPAIR
chr5:43377197-43381688:-THCAEERENSG00000173320,STOX2-0.47421.9413e-254.0008e-23-0.4273imageNADAR;HNRNPA1;PTBP1;SRSF1;U2AF2;UPF1NADendritic_cells_restingGSVA_HALLMARK_COAGULATION
chr5:43377197-43381688:-CESCEERENSG00000126264,HCST0.35968.6010e-064.2138e-110.4115imageNSRSF1HCSTT_cells_CD8GSVA_HALLMARK_ALLOGRAFT_REJECTION
chr5:43377197-43381688:-COADEERENSG00000039523,FAM65A0.25887.0054e-032.4344e-110.4426imageNADAR;HNRNPA1;PTBP1;RBM47;SRSF1;U2AF2;UPF1NAT_cells_CD4_memory_restingGSVA_HALLMARK_APICAL_SURFACE
chr5:43377197-43381688:-COADEERENSG00000239686,RP11-665C16.10.18323.0304e-023.5171e-120.4590imageNNNAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr5:43377197-43381688:-COADEERENSG00000270722,U10.19303.6044e-025.5498e-130.4738imageNNNADendritic_cells_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr5:43377197-43381688:-COADEERENSG00000111696,NT5DC30.20644.0770e-028.7500e-110.4313imageNADAR;HNRNPA1;PTBP1;RBM47;SRSF1;U2AF2;UPF1NADendritic_cells_activatedGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr5:43377197-43381688:-COADEERENSG00000262979,CTD-2047H16.20.20414.1419e-027.3571e-140.4893imageNHNRNPA1;U2AF2NAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr5:43377197-43381688:-COADEERENSG00000200665,RNU6-1188P0.10084.3695e-023.4658e-170.5418imageNNNANeutrophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr5:43377197-43381688:-COADEERENSG00000222009,BTBD190.20514.3901e-022.5346e-100.4215imageNADAR;HNRNPA1;PTBP1;SRSF1;U2AF2;UPF1NANeutrophilsGSVA_HALLMARK_PEROXISOME
chr5:43377197-43381688:-COADEERENSG00000170653,ATF70.20524.5469e-024.2180e-110.4378imageNADAR;HNRNPA1;PTBP1;RBM47;SRSF1;U2AF2;UPF1NANeutrophilsGSVA_HALLMARK_DNA_REPAIR
chr5:43377197-43381688:-THCAEERENSG00000173320,STOX2-0.47421.9413e-254.0008e-23-0.4273imageNADAR;HNRNPA1;PTBP1;SRSF1;U2AF2;UPF1NADendritic_cells_restingGSVA_HALLMARK_COAGULATION

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4. Enriched editing regions and immune related splicing for CCL28


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr5:43377197-43381688:-
COADEERA3ENSG00000219481.6chr116567978:16568030:16567178:16567271:16567178:165673510.06703.8280e-021.2266e-180.6048imageNADAR;HNRNPA1;PTBP1;RBM47;SRSF1;U2AF2;UPF1NADendritic_cells_activatedGSVA_HALLMARK_SPERMATOGENESIS
chr5:43377197-43381688:-
COADEERESENSG00000198561.8chr1157815393:57815500:57815914:57816001:57816299:57817940-0.29634.6421e-031.6069e-21-0.5999imageNADAR;HNRNPA1;PTBP1;RBM47;SRSF1;U2AF2;UPF1CTNND1NeutrophilsGSVA_HALLMARK_FATTY_ACID_METABOLISM
ENSG00000151882.10,CCL28
COADEAGA3ENSG00000219481.6chr116567978:16568030:16567178:16567271:16567178:165673510.06734.1485e-021.1586e-180.6052imageNADAR;CSTF2T;DDX54;DKC1;ELAVL1;FUS;HNRNPA1;HNRNPL;PTBP1;RBM47;SRSF1;TAF15;U2AF2;UPF1NADendritic_cells_activatedGSVA_HALLMARK_SPERMATOGENESIS
chr5:43377197-43381688:-
COADEERA5ENSG00000198561.8chr1157816299:57817940:57815393:57815500:57815393:578160010.29445.1960e-034.8202e-230.6175imageNADAR;HNRNPA1;PTBP1;RBM47;SRSF1;U2AF2;UPF1CTNND1Macrophages_M2GSVA_HALLMARK_FATTY_ACID_METABOLISM
ENSG00000151882.10,CCL28
COADEAGESENSG00000167632.10chr8140311247:140311374:140347756:140347946:140360049:1403601930.24821.1620e-026.5646e-200.5800imageNADAR;CSTF2T;DDX54;DKC1;ELAVL1;FUS;HNRNPA1;HNRNPL;PTBP1;RBM47;SRSF1;SRSF3;TAF15;U2AF2;UPF1NAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000151882.10,CCL28
COADEAGA5ENSG00000138614.10chr1565607301:65607442:65610795:65611069:65610685:656110690.25787.3963e-036.7600e-080.4097imageNADAR;CSTF2T;DDX54;DKC1;ELAVL1;FUS;HNRNPA1;HNRNPL;PTBP1;RBM47;SRSF1;SRSF3;TAF15;U2AF2;UPF1NADendritic_cells_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr5:43377197-43381688:-
COADEERIRENSG00000144802.7chr3101850262:101852224:101852737:1018527680.23682.5134e-022.1112e-140.5360imageNADAR;HNRNPA1;PTBP1;RBM47;SRSF1;U2AF2;UPF1NFKBIZEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr5:43377197-43381688:-
COADEERESENSG00000198561.8chr1157815393:57815500:57815917:57816001:57816299:57817940-0.27645.5885e-039.5668e-12-0.4739imageNADAR;HNRNPA1;PTBP1;RBM47;SRSF1;U2AF2;UPF1CTNND1NeutrophilsGSVA_HALLMARK_GLYCOLYSIS
ENSG00000151882.10,CCL28
COADEAGIRENSG00000104419.10chr8133258365:133258426:133259167:1332592300.24634.2960e-025.8972e-130.4734imageNADAR;CSTF2T;DDX54;DKC1;ELAVL1;FUS;HNRNPA1;HNRNPL;PTBP1;RBM47;SRSF1;SRSF3;TAF15;U2AF2;UPF1NDRG1NeutrophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr5:43377197-43381688:-
COADEERIRENSG00000104419.10chr8133258365:133258426:133259167:1332592300.24344.2553e-021.5286e-120.4658imageNADAR;HNRNPA1;PTBP1;RBM47;SRSF1;U2AF2;UPF1NDRG1NeutrophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE

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5. Enriched editing regions and immune infiltration for CCL28


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr5:43377197-43381688:-ACCEERMacrophages_M22.7233e-02-0.4171image
ENSG00000151882.10,CCL28ACCEAGMacrophages_M22.7233e-02-0.4171image
chr5:43377197-43381688:-BRCAEERB_cells_naive2.4750e-10-0.2244image
ENSG00000151882.10,CCL28BRCAEAGB_cells_naive2.4724e-10-0.2244image
chr5:43377197-43381688:-CESCEERT_cells_CD82.2446e-040.2375image
ENSG00000151882.10,CCL28CESCEAGT_cells_CD82.2446e-040.2375image
chr5:43377197-43381688:-CHOLEERMacrophages_M24.8200e-030.6038image
ENSG00000151882.10,CCL28CHOLEAGMacrophages_M24.8200e-030.6038image
chr5:43377197-43381688:-COADEERMast_cells_activated7.0468e-030.1868image
ENSG00000151882.10,CCL28COADEAGMast_cells_activated6.1981e-030.1897image
chr5:43377197-43381688:-ESCAEERT_cells_regulatory_(Tregs)4.4604e-04-0.2992image
ENSG00000151882.10,CCL28ESCAEAGT_cells_regulatory_(Tregs)4.5253e-04-0.2988image
chr5:43377197-43381688:-HNSCEERT_cells_CD4_memory_resting9.8048e-04-0.2159image
ENSG00000151882.10,CCL28HNSCEAGT_cells_CD4_memory_resting9.8048e-04-0.2159image
chr5:43377197-43381688:-KIRCEERT_cells_CD4_naive5.2991e-210.4826image
ENSG00000151882.10,CCL28KIRCEAGT_cells_CD4_naive5.2991e-210.4826image
chr5:43377197-43381688:-KIRPEEREosinophils2.4288e-070.3389image
ENSG00000151882.10,CCL28KIRPEAGEosinophils2.4288e-070.3389image
ENSG00000151882.10,CCL28LAMLEAGDendritic_cells_resting5.0824e-030.5146image
chr5:43377197-43381688:-LUADEERMacrophages_M13.2923e-020.1193image
ENSG00000151882.10,CCL28LUADEAGMacrophages_M13.2923e-020.1193image
chr5:43377197-43381688:-LUSCEERT_cells_CD4_memory_activated3.3949e-020.1279image
ENSG00000151882.10,CCL28LUSCEAGT_cells_CD4_memory_activated3.3949e-020.1279image
chr5:43377197-43381688:-OVEERB_cells_memory1.5490e-020.1459image
ENSG00000151882.10,CCL28OVEAGB_cells_memory1.5615e-020.1457image
chr5:43377197-43381688:-PAADEERDendritic_cells_resting1.9568e-03-0.2493image
ENSG00000151882.10,CCL28PAADEAGDendritic_cells_resting1.9568e-03-0.2493image
chr5:43377197-43381688:-PCPGEERPlasma_cells3.2890e-030.4706image
ENSG00000151882.10,CCL28PCPGEAGPlasma_cells3.2890e-030.4706image
chr5:43377197-43381688:-PRADEERT_cells_CD84.6513e-02-0.1628image
ENSG00000151882.10,CCL28PRADEAGT_cells_CD84.6513e-02-0.1628image
chr5:43377197-43381688:-READEERT_cells_CD4_naive4.1643e-030.3384image
ENSG00000151882.10,CCL28READEAGT_cells_CD4_naive4.1643e-030.3384image
chr5:43377197-43381688:-SARCEERDendritic_cells_activated4.6229e-02-0.2073image
ENSG00000151882.10,CCL28SARCEAGDendritic_cells_activated4.6229e-02-0.2073image
chr5:43377197-43381688:-SKCMEERNK_cells_activated1.5173e-020.1190image
ENSG00000151882.10,CCL28SKCMEAGNK_cells_activated1.5173e-020.1190image
chr5:43377197-43381688:-STADEERT_cells_CD88.5654e-040.1924image
ENSG00000151882.10,CCL28STADEAGT_cells_CD88.3215e-040.1929image
ENSG00000151882.10,CCL28TGCTEAGT_cells_regulatory_(Tregs)7.9668e-030.5087image
chr5:43377197-43381688:-THCAEERT_cells_regulatory_(Tregs)4.9787e-050.1824image
ENSG00000151882.10,CCL28THCAEAGT_cells_regulatory_(Tregs)5.0186e-050.1823image
chr5:43377197-43381688:-UCSEERB_cells_naive3.6187e-020.3606image
ENSG00000151882.10,CCL28UCSEAGB_cells_naive3.6187e-020.3606image
chr5:43377197-43381688:-UVMEERNeutrophils3.5294e-02-0.2746image
ENSG00000151882.10,CCL28UVMEAGNeutrophils3.5294e-02-0.2746image


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6. Enriched editing regions and immune gene sets for CCL28


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000151882.10,CCL28OVEAG2.1654e-02-0.13846.7418e-05-0.23798.4440e-04-0.20027.8186e-04-0.2014image
chr5:43377197-43381688:-OVEER2.1750e-02-0.13836.7618e-05-0.23798.4077e-04-0.20027.7457e-04-0.2016image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr5:43377197-43381688:-ACCGSVA_HALLMARK_MYC_TARGETS_V2EER4.4328e-020.3829image
ENSG00000151882.10,CCL28ACCGSVA_HALLMARK_MYC_TARGETS_V2EAG4.4328e-020.3829image
ENSG00000151882.10,CCL28BLCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG4.4385e-020.1921image
chr5:43377197-43381688:-BLCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER4.4385e-020.1921image
chr5:43377197-43381688:-BRCAGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER2.9550e-070.1825image
ENSG00000151882.10,CCL28BRCAGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG2.9540e-070.1825image
chr5:43377197-43381688:-CESCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER8.3393e-060.2850image
ENSG00000151882.10,CCL28CESCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG8.3393e-060.2850image
chr5:43377197-43381688:-CHOLGSVA_HALLMARK_ADIPOGENESISEER1.1028e-020.5553image
ENSG00000151882.10,CCL28CHOLGSVA_HALLMARK_ADIPOGENESISEAG1.1028e-020.5553image
chr5:43377197-43381688:-COADGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER5.9010e-05-0.2754image
ENSG00000151882.10,CCL28COADGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG5.4029e-05-0.2768image
chr5:43377197-43381688:-ESCAGSVA_HALLMARK_BILE_ACID_METABOLISMEER2.9406e-02-0.1882image
ENSG00000151882.10,CCL28ESCAGSVA_HALLMARK_BILE_ACID_METABOLISMEAG2.9491e-02-0.1881image
ENSG00000151882.10,CCL28HNSCGSVA_HALLMARK_MITOTIC_SPINDLEEAG8.4580e-05-0.2563image
chr5:43377197-43381688:-HNSCGSVA_HALLMARK_MITOTIC_SPINDLEEER8.4580e-05-0.2563image
ENSG00000151882.10,CCL28KIRCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG2.3434e-030.1655image
chr5:43377197-43381688:-KIRCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER2.3434e-030.1655image
chr5:43377197-43381688:-KIRPGSVA_HALLMARK_MYC_TARGETS_V2EER3.0580e-040.2406image
ENSG00000151882.10,CCL28KIRPGSVA_HALLMARK_MYC_TARGETS_V2EAG3.0580e-040.2406image
ENSG00000151882.10,CCL28LAMLGSVA_HALLMARK_COAGULATIONEAG2.7265e-02-0.4170image
chr5:43377197-43381688:-LIHCGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER9.5791e-030.2688image
ENSG00000151882.10,CCL28LIHCGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG9.5791e-030.2688image
ENSG00000151882.10,CCL28LUADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG5.8306e-040.1912image
chr5:43377197-43381688:-LUADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER5.8306e-040.1912image
chr5:43377197-43381688:-LUSCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.0411e-020.1543image
ENSG00000151882.10,CCL28LUSCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.0411e-020.1543image
chr5:43377197-43381688:-OVGSVA_HALLMARK_MITOTIC_SPINDLEEER3.0397e-08-0.3263image
ENSG00000151882.10,CCL28OVGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.0493e-08-0.3263image
chr5:43377197-43381688:-PAADGSVA_HALLMARK_BILE_ACID_METABOLISMEER4.1790e-03-0.2311image
ENSG00000151882.10,CCL28PAADGSVA_HALLMARK_BILE_ACID_METABOLISMEAG4.1790e-03-0.2311image
ENSG00000151882.10,CCL28PCPGGSVA_HALLMARK_G2M_CHECKPOINTEAG1.7830e-02-0.3874image
chr5:43377197-43381688:-PCPGGSVA_HALLMARK_G2M_CHECKPOINTEER1.7830e-02-0.3874image
ENSG00000151882.10,CCL28PRADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.4962e-05-0.3454image
chr5:43377197-43381688:-PRADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.4962e-05-0.3454image
chr5:43377197-43381688:-READGSVA_HALLMARK_PROTEIN_SECRETIONEER2.2615e-03-0.3592image
ENSG00000151882.10,CCL28READGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.2615e-03-0.3592image
ENSG00000151882.10,CCL28SARCGSVA_HALLMARK_MYC_TARGETS_V2EAG1.7458e-020.2460image
chr5:43377197-43381688:-SARCGSVA_HALLMARK_MYC_TARGETS_V2EER1.7458e-020.2460image
chr5:43377197-43381688:-SKCMGSVA_HALLMARK_PROTEIN_SECRETIONEER3.2360e-10-0.3019image
ENSG00000151882.10,CCL28SKCMGSVA_HALLMARK_PROTEIN_SECRETIONEAG3.2360e-10-0.3019image
ENSG00000151882.10,CCL28STADGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG2.7820e-030.1730image
chr5:43377197-43381688:-STADGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER2.9715e-030.1718image
ENSG00000151882.10,CCL28TGCTGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.8910e-020.4570image
chr5:43377197-43381688:-THCAGSVA_HALLMARK_COAGULATIONEER1.9003e-070.2329image
ENSG00000151882.10,CCL28THCAGSVA_HALLMARK_COAGULATIONEAG1.8373e-070.2332image
chr5:43377197-43381688:-THYMGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER7.4686e-040.6091image
ENSG00000151882.10,CCL28THYMGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG7.4686e-040.6091image
ENSG00000151882.10,CCL28UCECGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG3.9761e-020.1864image
chr5:43377197-43381688:-UCECGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER3.9761e-020.1864image
ENSG00000151882.10,CCL28UCSGSVA_HALLMARK_BILE_ACID_METABOLISMEAG4.5719e-02-0.3450image
chr5:43377197-43381688:-UCSGSVA_HALLMARK_BILE_ACID_METABOLISMEER4.5719e-02-0.3450image
chr5:43377197-43381688:-UVMGSVA_HALLMARK_APICAL_JUNCTIONEER7.5790e-030.3443image
ENSG00000151882.10,CCL28UVMGSVA_HALLMARK_APICAL_JUNCTIONEAG7.5790e-030.3443image


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7. Enriched editing regions and drugs for CCL28


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr5:43377197-43381688:-ACCMidostaurinEER1.6423e-02-0.4494image
ENSG00000151882.10,CCL28ACCMidostaurinEAG1.6423e-02-0.4494image
ENSG00000151882.10,CCL28BLCAJNJ.26854165EAG3.8458e-02-0.1977image
chr5:43377197-43381688:-BLCAJNJ.26854165EER3.8458e-02-0.1977image
chr5:43377197-43381688:-BRCAAP.24534EER1.1852e-040.1376image
ENSG00000151882.10,CCL28BRCAAP.24534EAG1.1837e-040.1376image
chr5:43377197-43381688:-CESCImatinibEER7.2195e-080.3411image
ENSG00000151882.10,CCL28CESCImatinibEAG7.2195e-080.3411image
chr5:43377197-43381688:-CHOLJNJ.26854165EER3.7965e-030.6165image
ENSG00000151882.10,CCL28CHOLJNJ.26854165EAG3.7965e-030.6165image
chr5:43377197-43381688:-COADJNJ.26854165EER8.2285e-07-0.3347image
ENSG00000151882.10,CCL28COADJNJ.26854165EAG6.4809e-07-0.3377image
chr5:43377197-43381688:-ESCAGDC.0449EER3.6977e-040.3043image
ENSG00000151882.10,CCL28ESCAGDC.0449EAG3.7355e-040.3041image
ENSG00000151882.10,CCL28HNSCAZD6482EAG1.2878e-060.3129image
chr5:43377197-43381688:-HNSCAZD6482EER1.2878e-060.3129image
ENSG00000151882.10,CCL28KIRCCGP.082996EAG1.0012e-05-0.2384image
chr5:43377197-43381688:-KIRCCGP.082996EER1.0012e-05-0.2384image
chr5:43377197-43381688:-KIRPAZD6482EER8.5054e-060.2945image
ENSG00000151882.10,CCL28KIRPAZD6482EAG8.5054e-060.2945image
ENSG00000151882.10,CCL28LAMLEmbelinEAG1.3805e-02-0.4599image
chr5:43377197-43381688:-LIHCBMS.708163EER9.3904e-030.2695image
ENSG00000151882.10,CCL28LIHCBMS.708163EAG9.3904e-030.2695image
ENSG00000151882.10,CCL28LUADEmbelinEAG4.3317e-05-0.2265image
chr5:43377197-43381688:-LUADEmbelinEER4.3317e-05-0.2265image
chr5:43377197-43381688:-LUSCGemcitabineEER8.7543e-03-0.1578image
ENSG00000151882.10,CCL28LUSCGemcitabineEAG8.7543e-03-0.1578image
chr5:43377197-43381688:-OVAZD.2281EER9.0999e-07-0.2915image
ENSG00000151882.10,CCL28OVAZD.2281EAG9.0431e-07-0.2916image
chr5:43377197-43381688:-PAADLapatinibEER1.5000e-020.2052image
ENSG00000151882.10,CCL28PAADLapatinibEAG1.5000e-020.2052image
ENSG00000151882.10,CCL28PCPGDMOGEAG4.2600e-02-0.3351image
chr5:43377197-43381688:-PCPGDMOGEER4.2600e-02-0.3351image
ENSG00000151882.10,CCL28PRADEHT.1864EAG2.6195e-02-0.1815image
chr5:43377197-43381688:-PRADEHT.1864EER2.6195e-02-0.1815image
chr5:43377197-43381688:-READEtoposideEER3.6380e-04-0.4142image
ENSG00000151882.10,CCL28READEtoposideEAG3.6380e-04-0.4142image
ENSG00000151882.10,CCL28SARCAZD.2281EAG3.2630e-04-0.3646image
chr5:43377197-43381688:-SARCAZD.2281EER3.2630e-04-0.3646image
chr5:43377197-43381688:-SKCMEmbelinEER5.7614e-110.3139image
ENSG00000151882.10,CCL28SKCMEmbelinEAG5.7614e-110.3139image
ENSG00000151882.10,CCL28STADA.770041EAG1.6672e-05-0.2474image
chr5:43377197-43381688:-STADA.770041EER1.6922e-05-0.2472image
ENSG00000151882.10,CCL28TGCTCGP.60474EAG7.9232e-03-0.5090image
chr5:43377197-43381688:-THCAEmbelinEER2.1604e-200.4018image
ENSG00000151882.10,CCL28THCAEmbelinEAG2.4111e-200.4013image
chr5:43377197-43381688:-THYMBortezomibEER1.8493e-02-0.4501image
ENSG00000151882.10,CCL28THYMBortezomibEAG1.8493e-02-0.4501image
ENSG00000151882.10,CCL28UCECCEP.701EAG4.8392e-05-0.3592image
chr5:43377197-43381688:-UCECCEP.701EER4.8392e-05-0.3592image
ENSG00000151882.10,CCL28UCSDoxorubicinEAG4.7450e-03-0.4728image
chr5:43377197-43381688:-UCSDoxorubicinEER4.7450e-03-0.4728image
chr5:43377197-43381688:-UVMGSK269962AEER1.1595e-05-0.5370image
ENSG00000151882.10,CCL28UVMGSK269962AEAG1.1595e-05-0.5370image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType