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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: MAPK13 (ImmuneEditome ID:5603)

1. Gene summary of enriched editing regions for MAPK13

check button Gene summary
Gene informationGene symbol

MAPK13

Gene ID

5603

GeneSynonymsMAPK 13|MAPK-13|PRKM13|SAPK4|p38delta
GeneCytomap

6p21.31

GeneTypeprotein-coding
GeneDescriptionmitogen-activated protein kinase 13|MAP kinase 13|MAP kinase p38 delta|mitogen-activated protein kinase p38 delta|stress-activated protein kinase 4
GeneModificationdate20230329
UniprotIDA0A024RD04;O15264;Q5R3E6
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr6:36140790-36141703:+ENST00000373766.8ENSG00000156711.15MAPK13UTR3L1MC2,MIR,AluSz,AluJbchr6:36140790-36141703:+.alignment


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2. Tumor-specific enriched editing regions for MAPK13


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
ENSG00000156711.15,MAPK13BRCAEAG8.9957e-03image
chr6:36140790-36141703:+COADEER8.8527e-17image
ENSG00000156711.15,MAPK13COADEAG6.6451e-14image
chr6:36140790-36141703:+HNSCEER6.8149e-07image
ENSG00000156711.15,MAPK13HNSCEAG2.0568e-02image
chr6:36140790-36141703:+KIRCEER7.5123e-06image
ENSG00000156711.15,MAPK13KIRCEAG3.1199e-03image
chr6:36140790-36141703:+LUADEER3.5758e-02image
chr6:36140790-36141703:+LUSCEER6.7234e-04image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr6:36140790-36141703:+KIRCPathEER1.6556e-021.9261e-020.1089image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for MAPK13


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr6:36140790-36141703:+BLCAEERENSG00000196465,MYL6B0.15153.7987e-026.1279e-140.4085imageNNNAMacrophages_M1GSVA_HALLMARK_DNA_REPAIR
chr6:36140790-36141703:+THCAEERENSG00000235043,TECRP10.24896.2531e-071.9453e-200.4018imageNNNANK_cells_activatedGSVA_HALLMARK_ANDROGEN_RESPONSE
chr6:36140790-36141703:+THCAEERENSG00000267673,FDX1L0.24321.1800e-062.1577e-220.4203imageNNNANK_cells_activatedGSVA_HALLMARK_UV_RESPONSE_DN
chr6:36140790-36141703:+THCAEERENSG00000174917,C19orf700.23921.7773e-063.1311e-220.4188imageNNNANK_cells_activatedGSVA_HALLMARK_UV_RESPONSE_DN
chr6:36140790-36141703:+THCAEERENSG00000126267,COX6B10.22994.9613e-061.9249e-220.4207imageNNNANK_cells_activatedGSVA_HALLMARK_UV_RESPONSE_DN
chr6:36140790-36141703:+THCAEERENSG00000241837,ATP5O0.22467.1023e-061.3303e-200.4034imageNNNAT_cells_CD8GSVA_HALLMARK_MITOTIC_SPINDLE
chr6:36140790-36141703:+THCAEERENSG00000131143,COX4I10.22279.6778e-069.2966e-220.4144imageNNNANK_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr6:36140790-36141703:+THCAEERENSG00000099795,NDUFB70.21123.3755e-052.2524e-210.4108imageNNNANK_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr6:36140790-36141703:+THCAEERENSG00000131495,NDUFA20.20217.4922e-053.0290e-220.4189imageNNNANK_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr6:36140790-36141703:+THCAEERENSG00000170906,NDUFA30.19989.4416e-056.6104e-220.4158imageNNNANK_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE

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4. Enriched editing regions and immune related splicing for MAPK13


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr6:36140790-36141703:+
COADEERA5ENSG00000137500.5chr1183280140:83280260:83285872:83285964:83285126:83285964-0.24501.2142e-027.2088e-12-0.4027imageNNNAEosinophilsGSVA_HALLMARK_P53_PATHWAY
ENSG00000156711.15,MAPK13
COADEAGMEXENSG00000120675.4chr1343055343:43055543:43058653:43058862:43058897:43062295:43065685:430657370.18174.1887e-026.6810e-170.5168imageNADAR;BCCIP;BUD13;CNBP;CSTF2T;DDX54;DICER1;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FUS;HNRNPA1;HNRNPC;HNRNPK;HNRNPM;IGF2BP1;IGF2BP3;LARP7;LIN28A;LIN28B;MOV10;NOP56;NOP58;PCBP2;PRPF8;RBFOX2;RBM47;SF3A3;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;U2AF1;U2AF2;UPF1NAMacrophages_M2GSVA_HALLMARK_UV_RESPONSE_DN
ENSG00000156711.15,MAPK13
COADEAGMEXENSG00000120675.4chr1343055343:43055543:43058653:43058862:43059393:43062295:43065685:430657370.19821.7026e-024.8705e-200.5577imageNADAR;BCCIP;BUD13;CNBP;CSTF2T;DDX54;DICER1;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FUS;HNRNPA1;HNRNPC;HNRNPK;HNRNPM;IGF2BP1;IGF2BP3;LARP7;LIN28A;LIN28B;MOV10;NOP56;NOP58;PCBP2;PRPF8;RBFOX2;RBM47;SF3A3;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;U2AF1;U2AF2;UPF1NAMacrophages_M2GSVA_HALLMARK_GLYCOLYSIS
ENSG00000156711.15,MAPK13
COADEAGA5ENSG00000137500.5chr1183280140:83280260:83285872:83285964:83285126:83285964-0.31392.1275e-043.1637e-14-0.4410imageNADAR;BUD13;CNBP;CSTF2T;DDX54;DICER1;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;HNRNPA1;HNRNPC;HNRNPK;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP3;KHDRBS2;LARP4B;LIN28;LIN28A;LIN28B;MOV10;NOP56;NOP58;PCBP2;PRPF8;RBFOX2;RBM10;RBM47;SF3B4;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;U2AF1;U2AF2;UPF1;ZNF184NAEosinophilsGSVA_HALLMARK_P53_PATHWAY
ENSG00000156711.15,MAPK13
COADEAGMEXENSG00000120675.4chr1343055343:43055543:43058653:43058862:43061466:43062295:43065685:430657370.18782.9624e-026.7458e-160.5030imageNADAR;BCCIP;BUD13;CNBP;CSTF2T;DDX54;DICER1;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FUS;HNRNPA1;HNRNPC;HNRNPK;HNRNPM;IGF2BP1;IGF2BP3;LARP7;LIN28A;LIN28B;MOV10;NOP56;NOP58;PCBP2;PRPF8;RBFOX2;RBM47;SF3A3;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;U2AF1;U2AF2;UPF1NAMacrophages_M2GSVA_HALLMARK_PROTEIN_SECRETION
ENSG00000156711.15,MAPK13
COADEAGMEXENSG00000120675.4chr1343055343:43055543:43058653:43058862:43061709:43062295:43065685:430657370.18763.0029e-025.7297e-160.5041imageNADAR;BCCIP;BUD13;CNBP;CSTF2T;DDX54;DICER1;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FUS;HNRNPA1;HNRNPC;HNRNPK;HNRNPM;IGF2BP1;IGF2BP3;LARP7;LIN28A;LIN28B;MOV10;NOP56;NOP58;PCBP2;PRPF8;RBFOX2;RBM47;SF3A3;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;U2AF1;U2AF2;UPF1NAMacrophages_M2GSVA_HALLMARK_PROTEIN_SECRETION
ENSG00000156711.15,MAPK13
COADEAGMEXENSG00000173915.8chr10103392190:103392283:103392370:103392381:103392381:103392466:103396408:1033964410.22104.5735e-024.0749e-130.4232imageNAUH;BCCIP;CNBP;CSTF2T;DDX42;DDX54;DICER1;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP3;KHDRBS2;LARP4B;LARP7;LIN28;LIN28A;LIN28B;MOV10;NONO;NOP56;NOP58;PCBP2;PRPF8;RBFOX2;RBM10;SF3A3;SF3B4;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;U2AF1;U2AF2;UPF1;ZNF184NAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr6:36140790-36141703:+
HNSCEERA3ENSG00000185722.12chr174169197:4169288:4163906:4164173:4163906:41679110.17091.0465e-022.7967e-170.4020imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr6:36140790-36141703:+
KIRCEERMEXENSG00000129657.10chr1777215792:77215805:77216036:77216062:77216075:77216192:77216257:772162700.10882.2231e-022.7837e-140.4360imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN
chr6:36140790-36141703:+
KIRCEERMEXENSG00000129657.10chr1777213917:77215896:77216036:77216062:77216075:77216192:77216257:772162700.10802.2788e-021.5835e-150.4530imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN

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5. Enriched editing regions and immune infiltration for MAPK13


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr6:36140790-36141703:+ACCEERMast_cells_resting1.4830e-020.4269image
ENSG00000156711.15,MAPK13ACCEAGNK_cells_activated4.9213e-020.3256image
chr6:36140790-36141703:+BLCAEERPlasma_cells3.2956e-020.1210image
ENSG00000156711.15,MAPK13BLCAEAGPlasma_cells1.1910e-020.1368image
chr6:36140790-36141703:+BRCAEERB_cells_naive1.8531e-04-0.1168image
chr6:36140790-36141703:+CESCEERMacrophages_M21.7507e-020.1445image
ENSG00000156711.15,MAPK13CESCEAGNeutrophils2.4233e-020.1330image
chr6:36140790-36141703:+CHOLEERT_cells_CD4_naive2.2890e-020.4142image
ENSG00000156711.15,MAPK13CHOLEAGT_cells_CD4_memory_activated9.2893e-030.4596image
chr6:36140790-36141703:+COADEERT_cells_regulatory_(Tregs)1.1814e-02-0.1536image
ENSG00000156711.15,MAPK13COADEAGT_cells_regulatory_(Tregs)1.1778e-02-0.1534image
chr6:36140790-36141703:+ESCAEERMacrophages_M21.7893e-030.2443image
ENSG00000156711.15,MAPK13ESCAEAGMacrophages_M27.8209e-040.2621image
chr6:36140790-36141703:+HNSCEERNK_cells_resting1.3480e-020.1209image
ENSG00000156711.15,MAPK13HNSCEAGT_cells_CD4_memory_activated3.1675e-02-0.1020image
chr6:36140790-36141703:+KIRCEERT_cells_regulatory_(Tregs)1.8523e-050.2310image
ENSG00000156711.15,MAPK13KIRCEAGPlasma_cells1.7954e-050.2287image
chr6:36140790-36141703:+KIRPEERT_cells_CD4_memory_activated1.1561e-040.2712image
ENSG00000156711.15,MAPK13KIRPEAGT_cells_CD4_memory_activated7.2878e-050.2754image
ENSG00000156711.15,MAPK13LAMLEAGNeutrophils1.1678e-030.6722image
chr6:36140790-36141703:+LGGEERMonocytes9.1632e-03-0.4603image
ENSG00000156711.15,MAPK13LGGEAGMonocytes1.6375e-02-0.3870image
chr6:36140790-36141703:+LIHCEERMonocytes3.8609e-020.2460image
ENSG00000156711.15,MAPK13LIHCEAGMonocytes3.1686e-020.2292image
chr6:36140790-36141703:+LUADEERMast_cells_resting7.7505e-03-0.1203image
chr6:36140790-36141703:+LUSCEERMacrophages_M14.6902e-030.1294image
ENSG00000156711.15,MAPK13LUSCEAGT_cells_regulatory_(Tregs)2.8436e-020.0994image
chr6:36140790-36141703:+MESOEERNeutrophils1.1346e-02-0.4634image
ENSG00000156711.15,MAPK13MESOEAGNeutrophils1.6365e-02-0.4347image
ENSG00000156711.15,MAPK13OVEAGMacrophages_M13.0996e-020.1333image
chr6:36140790-36141703:+PAADEERB_cells_memory4.2036e-030.2218image
ENSG00000156711.15,MAPK13PAADEAGPlasma_cells3.2138e-020.1640image
chr6:36140790-36141703:+PCPGEERNK_cells_resting3.4537e-030.2389image
ENSG00000156711.15,MAPK13PCPGEAGEosinophils1.8688e-030.2471image
chr6:36140790-36141703:+PRADEERDendritic_cells_resting1.2444e-02-0.1278image
chr6:36140790-36141703:+READEERNK_cells_activated2.5838e-020.2336image
ENSG00000156711.15,MAPK13READEAGNK_cells_activated4.2272e-020.2134image
ENSG00000156711.15,MAPK13SARCEAGNK_cells_activated8.1924e-030.3853image
chr6:36140790-36141703:+SKCMEERT_cells_CD4_memory_activated3.9888e-030.4040image
ENSG00000156711.15,MAPK13SKCMEAGT_cells_CD83.9171e-020.2764image
chr6:36140790-36141703:+STADEERMacrophages_M07.9478e-04-0.1763image
ENSG00000156711.15,MAPK13STADEAGMacrophages_M01.1738e-03-0.1699image
chr6:36140790-36141703:+TGCTEERDendritic_cells_activated2.5597e-030.6103image
ENSG00000156711.15,MAPK13TGCTEAGDendritic_cells_activated1.0601e-020.4597image
chr6:36140790-36141703:+THCAEERNK_cells_resting4.8336e-030.1271image
ENSG00000156711.15,MAPK13THCAEAGNK_cells_resting1.0476e-030.1475image
chr6:36140790-36141703:+THYMEERB_cells_memory2.1747e-020.3062image
ENSG00000156711.15,MAPK13THYMEAGB_cells_memory4.1448e-020.2444image
chr6:36140790-36141703:+UCECEERPlasma_cells2.6281e-02-0.2355image
ENSG00000156711.15,MAPK13UCECEAGPlasma_cells2.9597e-04-0.3386image


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6. Enriched editing regions and immune gene sets for MAPK13


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000156711.15,MAPK13OVEAG4.1973e-020.12589.6840e-040.20274.8793e-030.17343.5091e-020.1303image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000156711.15,MAPK13BLCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG9.7046e-04-0.1789image
chr6:36140790-36141703:+BLCAGSVA_HALLMARK_PROTEIN_SECRETIONEER1.5972e-02-0.1365image
ENSG00000156711.15,MAPK13BRCAGSVA_HALLMARK_HEME_METABOLISMEAG1.6469e-020.0743image
chr6:36140790-36141703:+BRCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER4.1745e-130.2244image
chr6:36140790-36141703:+CESCGSVA_HALLMARK_MITOTIC_SPINDLEEER2.6561e-03-0.1822image
ENSG00000156711.15,MAPK13CHOLGSVA_HALLMARK_COAGULATIONEAG1.3886e-02-0.4373image
chr6:36140790-36141703:+CHOLGSVA_HALLMARK_MYOGENESISEER2.8693e-03-0.5254image
chr6:36140790-36141703:+COADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER4.7730e-04-0.2119image
ENSG00000156711.15,MAPK13COADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG8.6765e-04-0.2019image
ENSG00000156711.15,MAPK13ESCAGSVA_HALLMARK_MYOGENESISEAG1.6651e-040.2925image
chr6:36140790-36141703:+ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER2.1975e-040.2873image
ENSG00000156711.15,MAPK13HNSCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.5859e-02-0.1058image
chr6:36140790-36141703:+HNSCGSVA_HALLMARK_HEME_METABOLISMEER6.0297e-05-0.1952image
chr6:36140790-36141703:+KICHGSVA_HALLMARK_NOTCH_SIGNALINGEER1.4307e-02-0.3228image
ENSG00000156711.15,MAPK13KICHGSVA_HALLMARK_NOTCH_SIGNALINGEAG1.5550e-02-0.3191image
ENSG00000156711.15,MAPK13KIRCGSVA_HALLMARK_DNA_REPAIREAG4.0139e-020.1106image
chr6:36140790-36141703:+KIRCGSVA_HALLMARK_UV_RESPONSE_DNEER3.3991e-05-0.2238image
chr6:36140790-36141703:+KIRPGSVA_HALLMARK_PROTEIN_SECRETIONEER4.6799e-05-0.2858image
ENSG00000156711.15,MAPK13KIRPGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.9471e-03-0.2082image
chr6:36140790-36141703:+LIHCGSVA_HALLMARK_FATTY_ACID_METABOLISMEER2.1672e-030.3581image
ENSG00000156711.15,MAPK13LIHCGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG1.9287e-020.2490image
chr6:36140790-36141703:+LUADGSVA_HALLMARK_PANCREAS_BETA_CELLSEER9.9809e-030.1164image
ENSG00000156711.15,MAPK13LUADGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG6.3289e-040.1525image
ENSG00000156711.15,MAPK13LUSCGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG4.8562e-05-0.1832image
chr6:36140790-36141703:+LUSCGSVA_HALLMARK_HEME_METABOLISMEER1.8394e-04-0.1706image
ENSG00000156711.15,MAPK13MESOGSVA_HALLMARK_COAGULATIONEAG5.1752e-03-0.4973image
chr6:36140790-36141703:+MESOGSVA_HALLMARK_COAGULATIONEER3.8609e-02-0.3860image
chr6:36140790-36141703:+OVGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.0140e-03-0.2062image
ENSG00000156711.15,MAPK13OVGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG1.3260e-030.1973image
ENSG00000156711.15,MAPK13PAADGSVA_HALLMARK_MYOGENESISEAG1.8011e-020.1807image
chr6:36140790-36141703:+PAADGSVA_HALLMARK_PROTEIN_SECRETIONEER3.5542e-03-0.2257image
chr6:36140790-36141703:+PCPGGSVA_HALLMARK_ANGIOGENESISEER4.6460e-020.1640image
ENSG00000156711.15,MAPK13PCPGGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.4461e-040.2996image
chr6:36140790-36141703:+PRADGSVA_HALLMARK_MITOTIC_SPINDLEEER1.0864e-05-0.2230image
ENSG00000156711.15,MAPK13PRADGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.8989e-02-0.1180image
ENSG00000156711.15,MAPK13SARCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG3.3624e-05-0.5714image
chr6:36140790-36141703:+SARCGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER1.6553e-03-0.5581image
chr6:36140790-36141703:+STADGSVA_HALLMARK_MITOTIC_SPINDLEEER2.6852e-04-0.1912image
ENSG00000156711.15,MAPK13STADGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.3562e-03-0.1678image
ENSG00000156711.15,MAPK13TGCTGSVA_HALLMARK_HYPOXIAEAG1.1806e-02-0.4536image
chr6:36140790-36141703:+TGCTGSVA_HALLMARK_DNA_REPAIREER5.8420e-030.5678image
ENSG00000156711.15,MAPK13THCAGSVA_HALLMARK_UV_RESPONSE_DNEAG1.3220e-05-0.1952image
chr6:36140790-36141703:+THCAGSVA_HALLMARK_UV_RESPONSE_DNEER1.1336e-08-0.2543image
chr6:36140790-36141703:+THYMGSVA_HALLMARK_PROTEIN_SECRETIONEER7.8631e-03-0.3517image
ENSG00000156711.15,MAPK13THYMGSVA_HALLMARK_UV_RESPONSE_DNEAG1.3868e-020.2929image
ENSG00000156711.15,MAPK13UCECGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG5.1913e-030.2647image
ENSG00000156711.15,MAPK13UCSGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG4.4202e-02-0.4057image


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7. Enriched editing regions and drugs for MAPK13


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000156711.15,MAPK13BLCAAICAREAG4.1226e-030.1559image
chr6:36140790-36141703:+BLCAA.770041EER4.7460e-03-0.1597image
chr6:36140790-36141703:+BRCACCT007093EER5.6590e-090.1812image
chr6:36140790-36141703:+CESCCEP.701EER1.0785e-04-0.2335image
ENSG00000156711.15,MAPK13CESCEmbelinEAG1.6908e-02-0.1409image
chr6:36140790-36141703:+CHOLLapatinibEER5.3732e-030.4954image
ENSG00000156711.15,MAPK13CHOLLapatinibEAG2.5870e-040.6113image
ENSG00000156711.15,MAPK13COADGW843682XEAG8.6366e-060.2675image
chr6:36140790-36141703:+COADBMS.708163EER4.4222e-03-0.1734image
ENSG00000156711.15,MAPK13ESCAGSK269962AEAG2.2578e-08-0.4231image
chr6:36140790-36141703:+ESCAGSK269962AEER1.0626e-07-0.4041image
ENSG00000156711.15,MAPK13HNSCBAY.61.3606EAG2.2979e-03-0.1443image
chr6:36140790-36141703:+HNSCBMS.509744EER4.4094e-08-0.2641image
ENSG00000156711.15,MAPK13KICHCCT007093EAG4.0040e-02-0.2728image
ENSG00000156711.15,MAPK13KIRCABT.263EAG8.8594e-030.1407image
chr6:36140790-36141703:+KIRCBMS.536924EER1.1167e-06-0.2620image
chr6:36140790-36141703:+KIRPAZD6244EER2.5186e-03-0.2141image
ENSG00000156711.15,MAPK13KIRPAZD6244EAG1.2943e-02-0.1746image
ENSG00000156711.15,MAPK13LAMLMidostaurinEAG2.5573e-020.4976image
chr6:36140790-36141703:+LGGKU.55933EER1.6931e-020.4258image
ENSG00000156711.15,MAPK13LIHCAZ628EAG2.2457e-020.2431image
chr6:36140790-36141703:+LIHCJNJ.26854165EER3.5677e-02-0.2498image
ENSG00000156711.15,MAPK13LUADGemcitabineEAG6.3157e-030.1221image
chr6:36140790-36141703:+LUADMethotrexateEER2.8489e-020.0992image
ENSG00000156711.15,MAPK13LUSCABT.888EAG1.1559e-03-0.1470image
chr6:36140790-36141703:+LUSCGDC.0449EER2.6630e-04-0.1664image
chr6:36140790-36141703:+MESOEpothilone.BEER1.9384e-02-0.4316image
ENSG00000156711.15,MAPK13MESOJNJ.26854165EAG2.9779e-020.3971image
ENSG00000156711.15,MAPK13OVGefitinibEAG5.0842e-060.2781image
chr6:36140790-36141703:+OVBAY.61.3606EER5.7850e-040.2157image
ENSG00000156711.15,MAPK13PAADBIBW2992EAG3.6166e-030.2214image
chr6:36140790-36141703:+PAADGDC0941EER2.1210e-02-0.1793image
ENSG00000156711.15,MAPK13PCPGJNJ.26854165EAG9.3205e-030.2076image
chr6:36140790-36141703:+PRADEmbelinEER5.9138e-050.2040image
ENSG00000156711.15,MAPK13PRADCCT007093EAG3.0740e-020.1087image
chr6:36140790-36141703:+READCMKEER5.2940e-03-0.2900image
ENSG00000156711.15,MAPK13READCMKEAG6.6168e-03-0.2827image
ENSG00000156711.15,MAPK13SARCCCT007093EAG1.1260e-02-0.3705image
chr6:36140790-36141703:+SARCBX.795EER1.4428e-020.4495image
chr6:36140790-36141703:+SKCMEHT.1864EER3.9271e-020.2955image
chr6:36140790-36141703:+STADJNJ.26854165EER2.9142e-05-0.2187image
ENSG00000156711.15,MAPK13STADJNJ.26854165EAG1.4163e-05-0.2260image
ENSG00000156711.15,MAPK13TGCTElesclomolEAG5.2642e-03-0.4964image
chr6:36140790-36141703:+TGCTElesclomolEER6.4916e-03-0.5619image
ENSG00000156711.15,MAPK13THCADMOGEAG6.2783e-100.2744image
chr6:36140790-36141703:+THCADMOGEER5.4833e-130.3182image
chr6:36140790-36141703:+THYMFTI.277EER1.7655e-030.4087image
ENSG00000156711.15,MAPK13THYMAS601245EAG1.2714e-02-0.2964image
chr6:36140790-36141703:+UCECGW.441756EER8.6639e-030.2767image
ENSG00000156711.15,MAPK13UCECBMS.754807EAG1.0459e-04-0.3615image
ENSG00000156711.15,MAPK13UCSBI.D1870EAG4.6145e-030.5475image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType
chr6:36140790-36141703:+ENST00000373766.8O15264DB01017MinocyclineSmallMoleculeDrug
chr6:36140790-36141703:+ENST00000373766.8O15264DB12010FostamatinibSmallMoleculeDrug