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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: PRKCSH (ImmuneEditome ID:5589)

1. Gene summary of enriched editing regions for PRKCSH

check button Gene summary
Gene informationGene symbol

PRKCSH

Gene ID

5589

GeneSynonymsAGE-R2|G19P1|GIIB|PCLD|PCLD1|PKCSH|PLD1|VASAP-60
GeneCytomap

19p13.2

GeneTypeprotein-coding
GeneDescriptionglucosidase 2 subunit beta|AGE-binding receptor 2|advanced glycation end-product receptor 2|glucosidase II subunit beta|hepatocystin|protein kinase C substrate 60.1 kDa protein heavy chain|protein kinase C substrate, 80 Kda protein
GeneModificationdate20230409
UniprotIDK7ELL7;P14314;A0A0C4DGP4;K7EJ70;K7EL27;K7EPW7;A0A7I2V2T6;K7EKX1;K7EIP3
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr19:11449537-11450618:+ENST00000591510.1ENSG00000130175.8PRKCSHncRNA_exonicAluSc8,AluSx1,AluSx,7SLRNAchr19:11449537-11450618:+.alignment


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2. Tumor-specific enriched editing regions for PRKCSH


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr19:11449537-11450618:+BRCAEER3.8693e-02image
ENSG00000130175.8,PRKCSHBRCAEAG3.8693e-02image
chr19:11449537-11450618:+COADEER2.3554e-06image
ENSG00000130175.8,PRKCSHCOADEAG2.2451e-06image
chr19:11449537-11450618:+KICHEER8.7845e-11image
ENSG00000130175.8,PRKCSHKICHEAG8.7845e-11image
chr19:11449537-11450618:+KIRCEER1.3294e-03image
ENSG00000130175.8,PRKCSHKIRCEAG1.3294e-03image
chr19:11449537-11450618:+KIRPEER4.3963e-04image
ENSG00000130175.8,PRKCSHKIRPEAG4.3963e-04image
chr19:11449537-11450618:+LIHCEER7.8254e-04image
ENSG00000130175.8,PRKCSHLIHCEAG7.8254e-04image
chr19:11449537-11450618:+LUADEER1.8129e-02image
ENSG00000130175.8,PRKCSHLUADEAG1.8130e-02image
chr19:11449537-11450618:+LUSCEER1.2691e-04image
ENSG00000130175.8,PRKCSHLUSCEAG1.2691e-04image
chr19:11449537-11450618:+PRADEER1.8086e-02image
ENSG00000130175.8,PRKCSHPRADEAG1.8086e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for PRKCSH


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr19:11449537-11450618:+UCECEERENSG00000202533,Y_RNA0.28211.4268e-026.7395e-090.4196imageNNNAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr19:11449537-11450618:+UCECEERENSG00000177570,SAMD120.27781.8914e-022.8818e-090.4288imageNDGCR8;EIF4A3;HNRNPA1;HNRNPU;IGF2BP1;RBFOX2;SRSF1NAT_cells_CD4_memory_restingGSVA_HALLMARK_DNA_REPAIR
chr19:11449537-11450618:+UCECEERENSG00000231551,RP11-495P10.10.27672.2578e-027.5195e-140.5249imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_UP
chr19:11449537-11450618:+UCECEERENSG00000095015,MAP3K10.26473.0410e-024.0600e-090.4252imageNDGCR8;EIF4A3;FAM120A;HNRNPA1;HNRNPU;IGF2BP1;PCBP2;PRPF8;RBFOX2;SLTM;SRSF1;U2AF1MAP3K1T_cells_CD4_memory_restingGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr19:11449537-11450618:+UCECEERENSG00000223878,AC005517.30.25663.7427e-022.1419e-130.5166imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_UP
chr19:11449537-11450618:+UCECEERENSG00000229152,ANKRD10-IT10.25494.1215e-021.9996e-150.5520imageNDGCR8;EIF4A3;FAM120A;HNRNPA1;HNRNPU;IGF2BP1;PCBP2;RBFOX2;SLTM;SRSF1NAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_UP
chr19:11449537-11450618:+LAMLEERENSG00000279236,RP11-120K19.30.32794.6052e-022.7008e-070.4064imageNEIF4A3;FAM120A;HNRNPA1;HNRNPU;RBFOX2NAT_cells_CD4_memory_activatedGSVA_HALLMARK_GLYCOLYSIS
chr19:11449537-11450618:+READEERENSG00000141858,SAMD1-0.52341.8182e-027.2580e-06-0.4422imageNDGCR8;EIF4A3;FAM120A;HNRNPA1;HNRNPU;IGF2BP1;PCBP2;PRPF8;RBFOX2;SLTM;SRSF1;U2AF1NAT_cells_CD4_naiveGSVA_HALLMARK_UV_RESPONSE_DN
chr19:11449537-11450618:+READEERENSG00000117411,B4GALT2-0.45484.7314e-027.6838e-06-0.4411imageNDGCR8;EIF4A3;FAM120A;HNRNPA1;HNRNPU;IGF2BP1;PCBP2;PRPF8;RBFOX2;SLTM;SRSF1;U2AF1NAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr19:11449537-11450618:+READEERENSG00000142409,ZNF787-0.46584.7768e-023.9210e-05-0.4087imageNDGCR8;EIF4A3;FAM120A;HNRNPA1;HNRNPU;IGF2BP1;PCBP2;PRPF8;RBFOX2;SRSF1;U2AF1NANK_cells_restingGSVA_HALLMARK_UV_RESPONSE_DN

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4. Enriched editing regions and immune related splicing for PRKCSH


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr19:11449537-11450618:+
UCECEERMEXENSG00000140105.13chr14100342397:100342571:100343274:100343387:100369086:100369258:100375282:100375333-0.33281.7350e-028.9200e-09-0.4210imageNDGCR8;EIF4A3;FAM120A;HNRNPA1;HNRNPU;IGF2BP1;PCBP2;PRPF8;RBFOX2;SLTM;SRSF1;U2AF1WARST_cells_CD4_memory_restingGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr19:11449537-11450618:+
UCECEERIRENSG00000122729.14chr932448895:32449081:32449997:324508320.33098.8355e-031.9437e-180.6165imageNDGCR8;EIF4A3;FAM120A;HNRNPA1;IGF2BP1;PCBP2;PRPF8;RBFOX2;SLTM;SRSF1;U2AF1NAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000130175.8,PRKCSH
UCECEAGIRENSG00000122729.14chr932448895:32449081:32449997:324508320.33118.9008e-031.9437e-180.6165imageNACIN1;ADAR;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;EIF4A3;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM47;RBM5;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;YTHDC1;YTHDF1NAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000130175.8,PRKCSH
UCECEAGMEXENSG00000140105.13chr14100342397:100342571:100343274:100343387:100369086:100369258:100375282:100375333-0.33271.7089e-029.6899e-09-0.4200imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184WARST_cells_CD4_memory_restingGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION

More results



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5. Enriched editing regions and immune infiltration for PRKCSH


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr19:11449537-11450618:+ACCEERMacrophages_M04.7044e-03-0.3169image
ENSG00000130175.8,PRKCSHACCEAGMacrophages_M04.7044e-03-0.3169image
chr19:11449537-11450618:+BLCAEERDendritic_cells_resting5.4570e-03-0.1378image
ENSG00000130175.8,PRKCSHBLCAEAGDendritic_cells_resting5.4547e-03-0.1379image
chr19:11449537-11450618:+BRCAEERMast_cells_resting2.4003e-050.1280image
ENSG00000130175.8,PRKCSHBRCAEAGMast_cells_resting2.4003e-050.1280image
chr19:11449537-11450618:+CESCEERMacrophages_M08.6020e-05-0.2233image
ENSG00000130175.8,PRKCSHCESCEAGMacrophages_M08.6020e-05-0.2233image
chr19:11449537-11450618:+COADEERDendritic_cells_activated2.3605e-020.1383image
ENSG00000130175.8,PRKCSHCOADEAGDendritic_cells_activated2.3605e-020.1383image
chr19:11449537-11450618:+DLBCEERMacrophages_M11.7481e-050.5772image
ENSG00000130175.8,PRKCSHDLBCEAGMacrophages_M11.7481e-050.5772image
chr19:11449537-11450618:+ESCAEERNK_cells_activated3.2122e-020.1690image
ENSG00000130175.8,PRKCSHESCAEAGNK_cells_activated3.2139e-020.1690image
chr19:11449537-11450618:+GBMEERMonocytes6.1177e-050.3050image
ENSG00000130175.8,PRKCSHGBMEAGMonocytes6.1177e-050.3050image
chr19:11449537-11450618:+HNSCEERMacrophages_M15.7778e-040.1534image
ENSG00000130175.8,PRKCSHHNSCEAGMacrophages_M15.7817e-040.1534image
chr19:11449537-11450618:+KICHEERMacrophages_M27.0714e-03-0.3310image
ENSG00000130175.8,PRKCSHKICHEAGMacrophages_M27.0714e-03-0.3310image
chr19:11449537-11450618:+KIRPEERT_cells_CD4_memory_resting3.6185e-02-0.1235image
ENSG00000130175.8,PRKCSHKIRPEAGT_cells_CD4_memory_resting3.6185e-02-0.1235image
chr19:11449537-11450618:+LAMLEERNK_cells_resting1.0529e-020.2090image
ENSG00000130175.8,PRKCSHLAMLEAGNK_cells_resting1.0529e-020.2090image
chr19:11449537-11450618:+LGGEEREosinophils3.3675e-030.1276image
ENSG00000130175.8,PRKCSHLGGEAGEosinophils3.3675e-030.1276image
chr19:11449537-11450618:+LUADEERT_cells_CD4_memory_resting1.0198e-030.1451image
ENSG00000130175.8,PRKCSHLUADEAGT_cells_CD4_memory_resting1.0196e-030.1451image
chr19:11449537-11450618:+LUSCEERB_cells_naive1.0404e-03-0.1465image
ENSG00000130175.8,PRKCSHLUSCEAGB_cells_naive1.0404e-03-0.1465image
chr19:11449537-11450618:+MESOEERDendritic_cells_activated3.4152e-030.3197image
ENSG00000130175.8,PRKCSHMESOEAGDendritic_cells_activated3.4152e-030.3197image
chr19:11449537-11450618:+OVEERNK_cells_activated8.3692e-040.1944image
ENSG00000130175.8,PRKCSHOVEAGNK_cells_activated8.3662e-040.1945image
chr19:11449537-11450618:+PAADEERMast_cells_resting1.1523e-020.1890image
ENSG00000130175.8,PRKCSHPAADEAGMast_cells_resting1.1523e-020.1890image
chr19:11449537-11450618:+PCPGEERMonocytes5.4637e-030.2046image
ENSG00000130175.8,PRKCSHPCPGEAGMonocytes5.4637e-030.2046image
chr19:11449537-11450618:+PRADEERMast_cells_resting1.8386e-04-0.1670image
ENSG00000130175.8,PRKCSHPRADEAGMast_cells_resting1.8386e-04-0.1670image
chr19:11449537-11450618:+READEERB_cells_naive3.4567e-020.2171image
ENSG00000130175.8,PRKCSHREADEAGB_cells_naive3.4567e-020.2171image
chr19:11449537-11450618:+SARCEERNK_cells_activated2.1483e-020.1434image
ENSG00000130175.8,PRKCSHSARCEAGNK_cells_activated2.1493e-020.1434image
chr19:11449537-11450618:+SKCMEERT_cells_CD81.4932e-050.1980image
ENSG00000130175.8,PRKCSHSKCMEAGT_cells_CD81.4888e-050.1981image
chr19:11449537-11450618:+STADEEREosinophils2.0938e-05-0.2192image
ENSG00000130175.8,PRKCSHSTADEAGEosinophils2.0726e-05-0.2194image
chr19:11449537-11450618:+TGCTEERDendritic_cells_activated2.7815e-03-0.2379image
ENSG00000130175.8,PRKCSHTGCTEAGDendritic_cells_activated2.7806e-03-0.2379image
chr19:11449537-11450618:+THCAEERMast_cells_resting2.2255e-02-0.1018image
ENSG00000130175.8,PRKCSHTHCAEAGMast_cells_resting2.2255e-02-0.1018image
chr19:11449537-11450618:+THYMEERT_cells_regulatory_(Tregs)1.3529e-09-0.5219image
ENSG00000130175.8,PRKCSHTHYMEAGT_cells_regulatory_(Tregs)1.3529e-09-0.5219image
chr19:11449537-11450618:+UCSEERT_cells_regulatory_(Tregs)2.7203e-030.3966image
ENSG00000130175.8,PRKCSHUCSEAGT_cells_regulatory_(Tregs)2.7203e-030.3966image


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6. Enriched editing regions and immune gene sets for PRKCSH


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr19:11449537-11450618:+BRCAEER3.1139e-02image1.0485e-020.0777image
ENSG00000130175.8,PRKCSHBRCAEAG3.1139e-02image1.0485e-020.0777image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr19:11449537-11450618:+THYMEER1.2451e-08-0.49472.8470e-11-0.56434.0647e-020.18881.0741e-060.4314image
ENSG00000130175.8,PRKCSHTHYMEAG1.2451e-08-0.49472.8470e-11-0.56434.0647e-020.18881.0741e-060.4314image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr19:11449537-11450618:+ACCGSVA_HALLMARK_G2M_CHECKPOINTEER3.2938e-04-0.3962image
ENSG00000130175.8,PRKCSHACCGSVA_HALLMARK_G2M_CHECKPOINTEAG3.2938e-04-0.3962image
ENSG00000130175.8,PRKCSHBLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG8.7953e-050.1936image
chr19:11449537-11450618:+BLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER8.7858e-050.1936image
ENSG00000130175.8,PRKCSHBRCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG6.8830e-110.1965image
chr19:11449537-11450618:+BRCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER6.8830e-110.1965image
ENSG00000130175.8,PRKCSHCESCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG2.5571e-100.3524image
chr19:11449537-11450618:+CESCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER2.5571e-100.3524image
chr19:11449537-11450618:+COADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.1428e-030.1976image
ENSG00000130175.8,PRKCSHCOADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.1428e-030.1976image
chr19:11449537-11450618:+DLBCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.5248e-030.4131image
ENSG00000130175.8,PRKCSHDLBCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.5248e-030.4131image
chr19:11449537-11450618:+ESCAGSVA_HALLMARK_MITOTIC_SPINDLEEER8.2238e-03-0.2076image
ENSG00000130175.8,PRKCSHESCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG8.2118e-03-0.2077image
chr19:11449537-11450618:+GBMGSVA_HALLMARK_BILE_ACID_METABOLISMEER3.4155e-050.3148image
ENSG00000130175.8,PRKCSHGBMGSVA_HALLMARK_BILE_ACID_METABOLISMEAG3.4155e-050.3148image
ENSG00000130175.8,PRKCSHHNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.2955e-060.2063image
chr19:11449537-11450618:+HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.2914e-060.2063image
ENSG00000130175.8,PRKCSHKIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.8993e-020.1054image
chr19:11449537-11450618:+KIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.8993e-020.1054image
chr19:11449537-11450618:+KIRPGSVA_HALLMARK_DNA_REPAIREER1.0724e-03-0.1918image
ENSG00000130175.8,PRKCSHKIRPGSVA_HALLMARK_DNA_REPAIREAG1.0724e-03-0.1918image
chr19:11449537-11450618:+LAMLGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.4698e-02-0.1995image
ENSG00000130175.8,PRKCSHLAMLGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.4698e-02-0.1995image
chr19:11449537-11450618:+LGGGSVA_HALLMARK_KRAS_SIGNALING_DNEER5.7066e-070.2160image
ENSG00000130175.8,PRKCSHLGGGSVA_HALLMARK_KRAS_SIGNALING_DNEAG5.7066e-070.2160image
ENSG00000130175.8,PRKCSHLIHCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.5797e-05-0.2215image
chr19:11449537-11450618:+LIHCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.5797e-05-0.2215image
chr19:11449537-11450618:+LUADGSVA_HALLMARK_DNA_REPAIREER1.2401e-03-0.1426image
ENSG00000130175.8,PRKCSHLUADGSVA_HALLMARK_DNA_REPAIREAG1.2401e-03-0.1426image
chr19:11449537-11450618:+LUSCGSVA_HALLMARK_ANGIOGENESISEER8.1104e-050.1757image
ENSG00000130175.8,PRKCSHLUSCGSVA_HALLMARK_ANGIOGENESISEAG8.1104e-050.1757image
chr19:11449537-11450618:+MESOGSVA_HALLMARK_G2M_CHECKPOINTEER9.2503e-04-0.3590image
ENSG00000130175.8,PRKCSHMESOGSVA_HALLMARK_G2M_CHECKPOINTEAG9.2503e-04-0.3590image
chr19:11449537-11450618:+OVGSVA_HALLMARK_HEME_METABOLISMEER1.5237e-03-0.1847image
ENSG00000130175.8,PRKCSHOVGSVA_HALLMARK_HEME_METABOLISMEAG1.5255e-03-0.1847image
ENSG00000130175.8,PRKCSHPAADGSVA_HALLMARK_KRAS_SIGNALING_DNEAG6.4769e-050.2948image
chr19:11449537-11450618:+PAADGSVA_HALLMARK_KRAS_SIGNALING_DNEER6.4769e-050.2948image
ENSG00000130175.8,PRKCSHPCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.2763e-03-0.2364image
chr19:11449537-11450618:+PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.2763e-03-0.2364image
ENSG00000130175.8,PRKCSHPRADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.8869e-080.2488image
chr19:11449537-11450618:+PRADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.8869e-080.2488image
chr19:11449537-11450618:+READGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.0809e-030.3303image
ENSG00000130175.8,PRKCSHREADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.0809e-030.3303image
ENSG00000130175.8,PRKCSHSARCGSVA_HALLMARK_MYC_TARGETS_V2EAG2.7686e-02-0.1374image
chr19:11449537-11450618:+SARCGSVA_HALLMARK_MYC_TARGETS_V2EER2.7689e-02-0.1373image
chr19:11449537-11450618:+SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.2537e-050.1998image
ENSG00000130175.8,PRKCSHSKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.2465e-050.1998image
ENSG00000130175.8,PRKCSHSTADGSVA_HALLMARK_HYPOXIAEAG2.4499e-02-0.1169image
chr19:11449537-11450618:+STADGSVA_HALLMARK_HYPOXIAEER2.5166e-02-0.1164image
chr19:11449537-11450618:+TGCTGSVA_HALLMARK_ANDROGEN_RESPONSEEER1.0875e-030.2592image
ENSG00000130175.8,PRKCSHTGCTGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.0894e-030.2591image
chr19:11449537-11450618:+THCAGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER3.5536e-030.1296image
ENSG00000130175.8,PRKCSHTHCAGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG3.5536e-030.1296image
chr19:11449537-11450618:+THYMGSVA_HALLMARK_E2F_TARGETSEER7.0189e-16-0.6565image
ENSG00000130175.8,PRKCSHTHYMGSVA_HALLMARK_E2F_TARGETSEAG7.0189e-16-0.6565image
chr19:11449537-11450618:+UCECGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.5014e-03-0.2375image
ENSG00000130175.8,PRKCSHUCECGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.5258e-03-0.2372image
ENSG00000130175.8,PRKCSHUCSGSVA_HALLMARK_APOPTOSISEAG1.0535e-020.3423image
chr19:11449537-11450618:+UCSGSVA_HALLMARK_APOPTOSISEER1.0535e-020.3423image
ENSG00000130175.8,PRKCSHUVMGSVA_HALLMARK_COMPLEMENTEAG1.3407e-020.2754image
chr19:11449537-11450618:+UVMGSVA_HALLMARK_COMPLEMENTEER1.3407e-020.2754image


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7. Enriched editing regions and drugs for PRKCSH


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr19:11449537-11450618:+ACCA.443654EER4.5932e-050.4444image
ENSG00000130175.8,PRKCSHACCA.443654EAG4.5932e-050.4444image
ENSG00000130175.8,PRKCSHBLCAElesclomolEAG6.5151e-040.1687image
chr19:11449537-11450618:+BLCAElesclomolEER6.5289e-040.1687image
ENSG00000130175.8,PRKCSHBRCACCT007093EAG1.2501e-11-0.2039image
chr19:11449537-11450618:+BRCACCT007093EER1.2501e-11-0.2039image
ENSG00000130175.8,PRKCSHCESCAZD6244EAG3.4086e-06-0.2628image
chr19:11449537-11450618:+CESCAZD6244EER3.4086e-06-0.2628image
chr19:11449537-11450618:+COADGefitinibEER7.4221e-05-0.2396image
ENSG00000130175.8,PRKCSHCOADGefitinibEAG7.4221e-05-0.2396image
chr19:11449537-11450618:+DLBCBMS.708163EER3.5500e-04-0.4944image
ENSG00000130175.8,PRKCSHDLBCBMS.708163EAG3.5500e-04-0.4944image
ENSG00000130175.8,PRKCSHESCAKU.55933EAG1.7078e-02-0.1883image
chr19:11449537-11450618:+ESCAKU.55933EER1.7053e-02-0.1884image
chr19:11449537-11450618:+GBMBIBW2992EER1.2355e-05-0.3312image
ENSG00000130175.8,PRKCSHGBMBIBW2992EAG1.2355e-05-0.3312image
ENSG00000130175.8,PRKCSHHNSCCI.1040EAG8.0801e-08-0.2371image
chr19:11449537-11450618:+HNSCCI.1040EER8.0650e-08-0.2371image
chr19:11449537-11450618:+KICHJNK.Inhibitor.VIIIEER2.1206e-04-0.4439image
ENSG00000130175.8,PRKCSHKICHJNK.Inhibitor.VIIIEAG2.1206e-04-0.4439image
ENSG00000130175.8,PRKCSHKIRCGDC0941EAG5.6927e-03-0.1412image
chr19:11449537-11450618:+KIRCGDC0941EER5.6927e-03-0.1412image
chr19:11449537-11450618:+KIRPEHT.1864EER1.5245e-060.2789image
ENSG00000130175.8,PRKCSHKIRPEHT.1864EAG1.5245e-060.2789image
ENSG00000130175.8,PRKCSHLAMLDMOGEAG3.8640e-02-0.1696image
chr19:11449537-11450618:+LAMLDMOGEER3.8640e-02-0.1696image
ENSG00000130175.8,PRKCSHLGGEtoposideEAG6.3851e-090.2497image
chr19:11449537-11450618:+LGGEtoposideEER6.3851e-090.2497image
chr19:11449537-11450618:+LIHCLenalidomideEER2.3493e-030.1573image
ENSG00000130175.8,PRKCSHLIHCLenalidomideEAG2.3493e-030.1573image
chr19:11449537-11450618:+LUADCGP.60474EER4.9968e-060.2006image
ENSG00000130175.8,PRKCSHLUADCGP.60474EAG4.9974e-060.2006image
ENSG00000130175.8,PRKCSHLUSCGW843682XEAG1.3795e-050.1934image
chr19:11449537-11450618:+LUSCGW843682XEER1.3795e-050.1934image
chr19:11449537-11450618:+MESOEmbelinEER1.0909e-020.2798image
ENSG00000130175.8,PRKCSHMESOEmbelinEAG1.0909e-020.2798image
chr19:11449537-11450618:+OVEmbelinEER8.6514e-050.2277image
ENSG00000130175.8,PRKCSHOVEmbelinEAG8.6641e-050.2277image
ENSG00000130175.8,PRKCSHPAADGW.441756EAG6.3041e-050.2953image
chr19:11449537-11450618:+PAADGW.441756EER6.3041e-050.2953image
ENSG00000130175.8,PRKCSHPCPGCamptothecinEAG6.1353e-030.2019image
chr19:11449537-11450618:+PCPGCamptothecinEER6.1353e-030.2019image
ENSG00000130175.8,PRKCSHPRADJNK.Inhibitor.VIIIEAG4.6863e-05-0.1815image
chr19:11449537-11450618:+PRADJNK.Inhibitor.VIIIEER4.6863e-05-0.1815image
chr19:11449537-11450618:+READGW843682XEER1.6554e-030.3185image
ENSG00000130175.8,PRKCSHREADGW843682XEAG1.6554e-030.3185image
chr19:11449537-11450618:+SARCDocetaxelEER8.7152e-030.1633image
ENSG00000130175.8,PRKCSHSARCDocetaxelEAG8.7203e-030.1633image
ENSG00000130175.8,PRKCSHSKCMDMOGEAG4.2014e-04-0.1619image
chr19:11449537-11450618:+SKCMDMOGEER4.2246e-04-0.1618image
ENSG00000130175.8,PRKCSHSTADCGP.60474EAG1.3058e-03-0.1665image
chr19:11449537-11450618:+STADCGP.60474EER1.3106e-03-0.1665image
chr19:11449537-11450618:+TGCTDMOGEER3.9918e-04-0.2800image
ENSG00000130175.8,PRKCSHTGCTDMOGEAG3.9980e-04-0.2800image
chr19:11449537-11450618:+THCABMS.708163EER7.5308e-03-0.1189image
ENSG00000130175.8,PRKCSHTHCABMS.708163EAG7.5308e-03-0.1189image
ENSG00000130175.8,PRKCSHTHYMBI.D1870EAG8.5338e-170.6716image
chr19:11449537-11450618:+THYMBI.D1870EER8.5338e-170.6716image
ENSG00000130175.8,PRKCSHUCECDocetaxelEAG6.5329e-060.3325image
chr19:11449537-11450618:+UCECDocetaxelEER6.1282e-060.3334image
chr19:11449537-11450618:+UCSMetforminEER2.4026e-03-0.4012image
ENSG00000130175.8,PRKCSHUCSMetforminEAG2.4026e-03-0.4012image
chr19:11449537-11450618:+UVMCCT007093EER5.4738e-03-0.3078image
ENSG00000130175.8,PRKCSHUVMCCT007093EAG5.4738e-03-0.3078image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType