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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: MREG (ImmuneEditome ID:55686)

1. Gene summary of enriched editing regions for MREG

check button Gene summary
Gene informationGene symbol

MREG

Gene ID

55686

GeneSynonymsDSU|WDT2
GeneCytomap

2q35

GeneTypeprotein-coding
GeneDescriptionmelanoregulin|dilute suppressor protein homolog|whn-dependent transcript 2
GeneModificationdate20230329
UniprotIDQ8N565;C9JYV9;C9JAG4;C9JFU1
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr2:215943536-215944339:-ENST00000620139.3ENSG00000118242.14MREGsplicingAluSc8,AluSg,Tigger14achr2:215943536-215944339:-.alignment
chr2:216030626-216031370:-ENST00000420348.1ENSG00000118242.14MREGintronicAluSx,(TC)n,(CA)n,AluSx1chr2:216030626-216031370:-.alignment
chr2:216030626-216031370:-ENST00000424992.4ENSG00000118242.14MREGintronicAluSx,(TC)n,(CA)n,AluSx1chr2:216030626-216031370:-.alignment
chr2:216030626-216031370:-ENST00000439791.4ENSG00000118242.14MREGintronicAluSx,(TC)n,(CA)n,AluSx1chr2:216030626-216031370:-.alignment


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2. Tumor-specific enriched editing regions for MREG


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr2:215943536-215944339:-BRCAEER2.1499e-40image
ENSG00000118242.14,MREGBRCAEAG5.2908e-38image
chr2:215943536-215944339:-HNSCEER9.0682e-22image
ENSG00000118242.14,MREGHNSCEAG1.8624e-21image
chr2:215943536-215944339:-KICHEER1.5989e-04image
ENSG00000118242.14,MREGKICHEAG1.5989e-04image
chr2:215943536-215944339:-KIRCEER1.4622e-08image
ENSG00000118242.14,MREGKIRCEAG5.9434e-09image
chr2:215943536-215944339:-LUADEER1.9676e-24image
ENSG00000118242.14,MREGLUADEAG2.5739e-23image
chr2:215943536-215944339:-LUSCEER4.3060e-06image
ENSG00000118242.14,MREGLUSCEAG6.1411e-06image
chr2:215943536-215944339:-PRADEER1.5142e-03image
ENSG00000118242.14,MREGPRADEAG1.5219e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000118242.14,MREGKIRCPathEAG3.0619e-036.3277e-040.1855image
chr2:215943536-215944339:-KIRCPathEER3.7094e-041.1346e-040.2112image
ENSG00000118242.14,MREGREADPathEAG4.6436e-037.5948e-03-0.2446image
chr2:215943536-215944339:-READPathEER4.6436e-037.5948e-03-0.2446image
ENSG00000118242.14,MREGTHCAPathEAG1.5765e-022.3941e-020.1031image
chr2:215943536-215944339:-THCAPathEER1.0298e-021.6966e-020.1089image
chr2:215943536-215944339:-UVMCliEER1.6292e-025.9694e-030.3087image
ENSG00000118242.14,MREGUVMCliEAG1.6292e-025.9694e-030.3087image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for MREG


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr2:215943536-215944339:-BLCAEERENSG00000160710,ADAR0.54194.5846e-261.2674e-290.5329imageNFUSADARMacrophages_M1GSVA_HALLMARK_MITOTIC_SPINDLE
chr2:215943536-215944339:-BLCAEERENSG00000156587,UBE2L60.49385.3623e-212.6531e-280.5221imageNFUSNAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr2:215943536-215944339:-BLCAEERENSG00000234745,HLA-B0.49158.3640e-211.9704e-290.5313imageNFUSHLA-BT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr2:215943536-215944339:-BLCAEERENSG00000204267,TAP20.48871.5451e-202.0054e-280.5231imageNFUSTAP2T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr2:215943536-215944339:-BLCAEERENSG00000240065,PSMB90.48165.7327e-202.2113e-270.5143imageNFUSPSMB9T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr2:215943536-215944339:-BLCAEERENSG00000168394,TAP10.48177.4343e-201.1481e-270.5167imageNFUSTAP1T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr2:215943536-215944339:-BLCAEERENSG00000134470,IL15RA0.47502.3379e-191.2035e-250.4991imageNFUSIL15RAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr2:215943536-215944339:-BLCAEERENSG00000089692,LAG30.47383.5834e-195.1920e-210.4544imageNFUSLAG3T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr2:215943536-215944339:-BLCAEERENSG00000204525,HLA-C0.47037.9828e-191.7816e-260.5065imageNFUSHLA-CT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr2:215943536-215944339:-BLCAEERENSG00000134326,CMPK20.46581.6093e-185.1900e-170.4096imageNFUSNAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE

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4. Enriched editing regions and immune related splicing for MREG


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr2:215943536-215944339:-
BLCAEERIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.66132.0961e-421.8696e-47-0.6493imageNFUSPRKCSHMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr2:215943536-215944339:-
BLCAEERIRENSG00000076928.13chr1941897314:41898113:41898441:41898587-0.36015.6022e-112.7632e-15-0.4050imageNFUSNAT_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr2:215943536-215944339:-
BLCAEERESENSG00000083457.7chr173720306:3720402:3723287:3723383:3723687:37237440.46666.2717e-171.9542e-270.5153imageNFUSITGAET_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
ENSG00000118242.14,MREG
BLCAEAGIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.65021.2274e-401.2231e-46-0.6436imageNACIN1;ADAR;AIFM1;BCCIP;CAPRIN1;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR2;GNL3;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28A;LIN28B;MOV10;MSI1;NOP56;NOP58;PCBP2;PRPF8;PTBP1;PUM2;RANGAP1;RBFOX2;RBM10;RBM47;RBM5;SF3B4;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIAL1;U2AF1;U2AF2;UPF1;YTHDC1;ZNF184PRKCSHMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
ENSG00000118242.14,MREG
BLCAEAGIRENSG00000076928.13chr1941897314:41898113:41898441:41898587-0.35202.1763e-103.8547e-15-0.4020imageNADAR;AIFM1;BCCIP;CELF2;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR2;GNL3;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHSRP;LARP7;LIN28A;LIN28B;MOV10;MSI1;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SF3B4;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;U2AF1;U2AF2;UPF1;YTHDC1;ZNF184NAT_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
ENSG00000118242.14,MREG
BLCAEAGESENSG00000083457.7chr173720306:3720402:3723287:3723383:3723687:37237440.45525.9084e-161.7600e-240.4874imageNACIN1;ADAR;AIFM1;BCCIP;CAPRIN1;CELF2;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;GNL3;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS2;KHDRBS3;KHSRP;LIN28B;MOV10;MSI1;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SF3B4;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIAL1;U2AF1;U2AF2;UPF1;WTAP;ZNF184ITGAET_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr2:215943536-215944339:-
BRCAEERIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.47401.0120e-545.5110e-60-0.4713imageNFUSPRKCSHT_cells_regulatory_(Tregs)GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
ENSG00000118242.14,MREG
BRCAEAGIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.47211.8532e-547.0227e-60-0.4709imageNACIN1;ADAR;AIFM1;BCCIP;CAPRIN1;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR2;GNL3;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28A;LIN28B;MOV10;MSI1;NOP56;NOP58;PCBP2;PRPF8;PTBP1;PUM2;RANGAP1;RBFOX2;RBM10;RBM47;RBM5;SF3B4;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIAL1;U2AF1;U2AF2;UPF1;YTHDC1;ZNF184PRKCSHT_cells_regulatory_(Tregs)GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr2:215943536-215944339:-
CESCEERIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.59064.4542e-231.0045e-31-0.6105imageNFUSPRKCSHMacrophages_M0GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
ENSG00000118242.14,MREG
CESCEAGIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.58481.9581e-222.5685e-31-0.6073imageNACIN1;ADAR;AIFM1;BCCIP;CAPRIN1;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR2;GNL3;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28A;LIN28B;MOV10;MSI1;NOP56;NOP58;PCBP2;PRPF8;PTBP1;PUM2;RANGAP1;RBFOX2;RBM10;RBM47;RBM5;SF3B4;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIAL1;U2AF1;U2AF2;UPF1;YTHDC1;ZNF184PRKCSHMacrophages_M0GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE

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5. Enriched editing regions and immune infiltration for MREG


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr2:215943536-215944339:-ACCEERMacrophages_M12.4309e-020.3182image
ENSG00000118242.14,MREGACCEAGMacrophages_M12.4309e-020.3182image
chr2:215943536-215944339:-BLCAEERT_cells_CD4_memory_activated2.7239e-120.3464image
ENSG00000118242.14,MREGBLCAEAGT_cells_CD4_memory_activated2.2508e-120.3463image
chr2:215943536-215944339:-BRCAEERMacrophages_M11.2462e-110.2050image
ENSG00000118242.14,MREGBRCAEAGMacrophages_M16.4024e-110.1978image
chr2:215943536-215944339:-CESCEERMacrophages_M14.6596e-050.2340image
ENSG00000118242.14,MREGCESCEAGMacrophages_M11.0952e-040.2226image
chr2:215943536-215944339:-CHOLEERNK_cells_activated1.9268e-020.4054image
ENSG00000118242.14,MREGCHOLEAGT_cells_regulatory_(Tregs)1.9968e-020.4032image
chr2:215943536-215944339:-COADEERMacrophages_M11.3013e-040.2486image
ENSG00000118242.14,MREGCOADEAGMacrophages_M11.4899e-030.2074image
chr2:215943536-215944339:-DLBCEERNeutrophils4.0052e-030.4163image
ENSG00000118242.14,MREGDLBCEAGMacrophages_M11.7931e-030.4480image
chr2:215943536-215944339:-ESCAEERMonocytes2.2592e-02-0.1808image
ENSG00000118242.14,MREGESCAEAGMonocytes2.4244e-02-0.1787image
chr2:215943536-215944339:-GBMEERMacrophages_M12.4574e-030.2371image
ENSG00000118242.14,MREGGBMEAGMacrophages_M12.4574e-030.2371image
chr2:215943536-215944339:-HNSCEERMacrophages_M15.3793e-160.3550image
ENSG00000118242.14,MREGHNSCEAGMacrophages_M12.1741e-160.3594image
chr2:215943536-215944339:-KICHEERMacrophages_M22.0499e-04-0.4581image
ENSG00000118242.14,MREGKICHEAGMacrophages_M22.0499e-04-0.4581image
chr2:215943536-215944339:-KIRCEERT_cells_CD85.9438e-040.2183image
ENSG00000118242.14,MREGKIRCEAGT_cells_CD83.4407e-030.1844image
chr2:215943536-215944339:-KIRPEERT_cells_CD81.0415e-020.1712image
chr2:216030626-216031370:-KIRPEERNeutrophils1.3007e-020.4803image
ENSG00000118242.14,MREGKIRPEAGMast_cells_resting7.1801e-03-0.1784image
chr2:215943536-215944339:-LGGEERT_cells_regulatory_(Tregs)2.1622e-03-0.1427image
ENSG00000118242.14,MREGLGGEAGT_cells_regulatory_(Tregs)2.1583e-03-0.1427image
chr2:215943536-215944339:-LIHCEERMacrophages_M13.4640e-020.1379image
ENSG00000118242.14,MREGLIHCEAGMacrophages_M16.6685e-050.2495image
chr2:215943536-215944339:-LUADEERT_cells_CD4_memory_activated6.0897e-080.2395image
ENSG00000118242.14,MREGLUADEAGT_cells_CD4_memory_activated2.4049e-070.2285image
chr2:215943536-215944339:-LUSCEERT_cells_CD81.4482e-180.3808image
ENSG00000118242.14,MREGLUSCEAGT_cells_CD83.3470e-180.3770image
chr2:215943536-215944339:-MESOEERT_cells_CD82.2314e-040.4948image
ENSG00000118242.14,MREGMESOEAGT_cells_CD84.4408e-040.4739image
chr2:215943536-215944339:-OVEERT_cells_CD87.5252e-040.1995image
ENSG00000118242.14,MREGOVEAGT_cells_CD84.5989e-030.1683image
chr2:215943536-215944339:-PAADEERT_cells_follicular_helper1.6631e-020.1903image
ENSG00000118242.14,MREGPAADEAGT_cells_follicular_helper1.8149e-020.1878image
chr2:215943536-215944339:-PCPGEERMacrophages_M13.3978e-050.3070image
ENSG00000118242.14,MREGPCPGEAGMacrophages_M13.3692e-050.3072image
chr2:215943536-215944339:-PRADEERNK_cells_resting2.0637e-020.2028image
ENSG00000118242.14,MREGPRADEAGNK_cells_resting2.1101e-020.2014image
chr2:215943536-215944339:-SARCEERMacrophages_M12.3013e-040.4449image
ENSG00000118242.14,MREGSARCEAGMacrophages_M12.3013e-040.4449image
chr2:215943536-215944339:-SKCMEERT_cells_CD82.5583e-180.3894image
ENSG00000118242.14,MREGSKCMEAGT_cells_CD83.6559e-180.3877image
chr2:215943536-215944339:-STADEERT_cells_CD4_memory_resting2.1362e-02-0.1479image
chr2:215943536-215944339:-TGCTEERMacrophages_M24.0460e-12-0.5352image
ENSG00000118242.14,MREGTGCTEAGMacrophages_M27.4252e-12-0.5296image
chr2:215943536-215944339:-THCAEERT_cells_CD4_memory_activated3.5487e-090.2651image
ENSG00000118242.14,MREGTHCAEAGT_cells_CD4_memory_activated3.3877e-090.2654image
chr2:215943536-215944339:-THYMEERMacrophages_M12.2700e-090.5610image
ENSG00000118242.14,MREGTHYMEAGMacrophages_M12.2693e-090.5610image
chr2:215943536-215944339:-UCECEERDendritic_cells_activated3.3570e-040.2767image
ENSG00000118242.14,MREGUCECEAGDendritic_cells_activated3.0462e-040.2785image
chr2:215943536-215944339:-UCSEERT_cells_CD4_memory_activated5.2229e-040.4730image
ENSG00000118242.14,MREGUCSEAGT_cells_CD4_memory_activated2.8360e-040.4921image
chr2:215943536-215944339:-UVMEERT_cells_CD82.4752e-060.5046image
ENSG00000118242.14,MREGUVMEAGT_cells_CD82.4752e-060.5046image


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6. Enriched editing regions and immune gene sets for MREG


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr2:215943536-215944339:-BLCAEER1.2357e-02image1.8030e-070.2622image
ENSG00000118242.14,MREGBLCAEAG9.1539e-03image4.6155e-080.2731image
chr2:215943536-215944339:-HNSCEER7.6760e-04image2.4633e-050.1893image
ENSG00000118242.14,MREGHNSCEAG1.1807e-03image2.2124e-050.1904image
chr2:215943536-215944339:-KIRPEER4.8045e-02image2.4185e-020.1509image
ENSG00000118242.14,MREGKIRPEAG3.2273e-02image1.2149e-020.1666image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr2:215943536-215944339:-BLCAEER1.3816e-060.24312.7760e-040.18439.6406e-060.22343.6561e-070.2557image
ENSG00000118242.14,MREGBLCAEAG1.0030e-070.26649.3460e-050.19702.6838e-060.23578.3612e-080.2679image
chr2:215943536-215944339:-HNSCEER3.3351e-020.09626.0980e-03-0.12371.3241e-020.11182.8867e-050.1877image
chr2:215943536-215944339:-LUADEER4.8292e-090.25821.4756e-110.29619.3616e-110.28461.1150e-040.1721image
ENSG00000118242.14,MREGLUADEAG1.6986e-080.24893.7623e-110.29013.3638e-100.27611.4457e-040.1692image
chr2:215943536-215944339:-THYMEER3.0946e-02-0.21931.1317e-04-0.38201.1278e-020.25634.2521e-090.5530image
ENSG00000118242.14,MREGTHYMEAG3.0996e-02-0.21921.1370e-04-0.38181.1249e-020.25644.2471e-090.5530image
ENSG00000118242.14,MREGUVMEAG4.7967e-030.31622.2392e-020.25835.9200e-030.30901.5525e-030.3524image
chr2:215943536-215944339:-UVMEER4.7967e-030.31622.2392e-020.25835.9200e-030.30901.5525e-030.3524image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr2:215943536-215944339:-ACCGSVA_HALLMARK_COAGULATIONEER7.0821e-040.4631image
ENSG00000118242.14,MREGACCGSVA_HALLMARK_COAGULATIONEAG7.0821e-040.4631image
chr2:215943536-215944339:-BLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER7.9838e-260.5007image
ENSG00000118242.14,MREGBLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG4.8144e-250.4920image
ENSG00000118242.14,MREGBRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.2852e-540.4492image
chr2:215943536-215944339:-BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.5741e-560.4568image
ENSG00000118242.14,MREGCESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG5.1332e-280.5793image
chr2:215943536-215944339:-CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.7038e-290.5877image
ENSG00000118242.14,MREGCHOLGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.3212e-02-0.4270image
chr2:215943536-215944339:-CHOLGSVA_HALLMARK_GLYCOLYSISEER2.5383e-02-0.3887image
ENSG00000118242.14,MREGCOADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.1563e-060.2919image
chr2:215943536-215944339:-COADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.3392e-060.3111image
chr2:215943536-215944339:-DLBCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER2.7662e-020.3248image
ENSG00000118242.14,MREGDLBCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG3.9118e-020.3053image
ENSG00000118242.14,MREGESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.3559e-060.3552image
chr2:215943536-215944339:-ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.1003e-060.3561image
chr2:215943536-215944339:-GBMGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.1206e-030.2545image
ENSG00000118242.14,MREGGBMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.1206e-030.2545image
chr2:215943536-215944339:-HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER6.8998e-470.5880image
ENSG00000118242.14,MREGHNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.6160e-470.5880image
ENSG00000118242.14,MREGKICHGSVA_HALLMARK_APICAL_SURFACEEAG5.2646e-03-0.3530image
chr2:215943536-215944339:-KICHGSVA_HALLMARK_APICAL_SURFACEEER5.2646e-03-0.3530image
chr2:215943536-215944339:-KIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.6670e-070.3274image
ENSG00000118242.14,MREGKIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.5319e-050.2584image
ENSG00000118242.14,MREGKIRPGSVA_HALLMARK_UV_RESPONSE_UPEAG3.4822e-060.3030image
chr2:215943536-215944339:-KIRPGSVA_HALLMARK_UV_RESPONSE_UPEER3.2164e-060.3060image
ENSG00000118242.14,MREGLGGGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.2499e-080.2615image
chr2:215943536-215944339:-LGGGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.2141e-080.2617image
ENSG00000118242.14,MREGLIHCGSVA_HALLMARK_ANDROGEN_RESPONSEEAG5.2489e-070.3110image
chr2:216030626-216031370:-LIHCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER5.6596e-030.5949image
chr2:215943536-215944339:-LIHCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.3360e-030.1976image
ENSG00000118242.14,MREGLUADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.0322e-160.3564image
chr2:215943536-215944339:-LUADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.6955e-160.3538image
ENSG00000118242.14,MREGLUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.9382e-330.5028image
chr2:215943536-215944339:-LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.0338e-330.5067image
chr2:215943536-215944339:-MESOGSVA_HALLMARK_FATTY_ACID_METABOLISMEER2.5892e-03-0.4131image
ENSG00000118242.14,MREGMESOGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG2.5511e-03-0.4136image
ENSG00000118242.14,MREGOVGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG4.2559e-120.3972image
chr2:215943536-215944339:-OVGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER3.4823e-140.4310image
chr2:215943536-215944339:-PAADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.1137e-040.2832image
ENSG00000118242.14,MREGPAADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG5.9861e-040.2701image
chr2:215943536-215944339:-PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER9.9322e-040.2461image
ENSG00000118242.14,MREGPCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG9.8405e-040.2463image
chr2:215943536-215944339:-PRADGSVA_HALLMARK_ANDROGEN_RESPONSEEER1.3842e-02-0.2154image
ENSG00000118242.14,MREGPRADGSVA_HALLMARK_ANDROGEN_RESPONSEEAG8.6702e-03-0.2285image
ENSG00000118242.14,MREGREADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG5.2096e-050.4441image
chr2:215943536-215944339:-READGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER5.2096e-050.4441image
chr2:215943536-215944339:-SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.4201e-040.4579image
ENSG00000118242.14,MREGSARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.4201e-040.4579image
chr2:215943536-215944339:-SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.0183e-220.4286image
ENSG00000118242.14,MREGSKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG7.7490e-230.4341image
chr2:215943536-215944339:-STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER8.2344e-060.2822image
ENSG00000118242.14,MREGSTADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG9.9708e-030.1624image
chr2:215943536-215944339:-TGCTGSVA_HALLMARK_ANGIOGENESISEER2.2273e-09-0.4711image
ENSG00000118242.14,MREGTGCTGSVA_HALLMARK_ANGIOGENESISEAG6.8932e-09-0.4581image
ENSG00000118242.14,MREGTHCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG8.1920e-100.2753image
chr2:215943536-215944339:-THCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER4.6479e-100.2792image
chr2:215943536-215944339:-THYMGSVA_HALLMARK_HYPOXIAEER4.2521e-090.5530image
ENSG00000118242.14,MREGTHYMGSVA_HALLMARK_HYPOXIAEAG4.2471e-090.5530image
chr2:215943536-215944339:-UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.2672e-090.4455image
ENSG00000118242.14,MREGUCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.1343e-090.4461image
chr2:215943536-215944339:-UCSGSVA_HALLMARK_GLYCOLYSISEER2.0648e-030.4255image
ENSG00000118242.14,MREGUCSGSVA_HALLMARK_GLYCOLYSISEAG1.1166e-030.4476image
ENSG00000118242.14,MREGUVMGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.3601e-060.5156image
chr2:215943536-215944339:-UVMGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.3601e-060.5156image


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7. Enriched editing regions and drugs for MREG


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000118242.14,MREGACCEHT.1864EAG2.9556e-040.4908image
chr2:215943536-215944339:-ACCEHT.1864EER2.9556e-040.4908image
chr2:215943536-215944339:-BLCACGP.60474EER6.3673e-18-0.4204image
ENSG00000118242.14,MREGBLCACGP.60474EAG2.1244e-16-0.4007image
ENSG00000118242.14,MREGBRCACGP.082996EAG2.6682e-14-0.2297image
chr2:215943536-215944339:-BRCACGP.082996EER2.2352e-15-0.2390image
ENSG00000118242.14,MREGCESCCI.1040EAG3.9224e-11-0.3712image
chr2:215943536-215944339:-CESCCI.1040EER1.9308e-11-0.3766image
ENSG00000118242.14,MREGCHOLBMS.536924EAG3.1859e-040.5882image
chr2:215943536-215944339:-CHOLBMS.509744EER5.6246e-030.4714image
ENSG00000118242.14,MREGCOADJNJ.26854165EAG8.6142e-06-0.2875image
chr2:215943536-215944339:-COADJNJ.26854165EER4.5160e-05-0.2645image
chr2:215943536-215944339:-DLBCABT.263EER2.5220e-02-0.3298image
ENSG00000118242.14,MREGDLBCABT.263EAG2.9876e-02-0.3205image
ENSG00000118242.14,MREGESCAGDC.0449EAG2.1356e-02-0.1830image
chr2:215943536-215944339:-ESCAGDC.0449EER2.5143e-02-0.1781image
chr2:215943536-215944339:-GBMCytarabineEER5.7667e-060.3488image
ENSG00000118242.14,MREGGBMCytarabineEAG5.7667e-060.3488image
ENSG00000118242.14,MREGHNSCCGP.60474EAG1.4596e-11-0.2988image
chr2:215943536-215944339:-HNSCCGP.60474EER2.9067e-12-0.3085image
chr2:215943536-215944339:-KICHIPA.3EER2.1611e-03-0.3854image
ENSG00000118242.14,MREGKICHIPA.3EAG2.1611e-03-0.3854image
chr2:215943536-215944339:-KIRCCamptothecinEER8.8025e-07-0.3086image
ENSG00000118242.14,MREGKIRCGSK269962AEAG3.0396e-05-0.2605image
chr2:216030626-216031370:-KIRPCytarabineEER1.3136e-02-0.4797image
ENSG00000118242.14,MREGKIRPCCT018159EAG5.0825e-050.2661image
chr2:215943536-215944339:-KIRPCCT018159EER3.2116e-050.2746image
ENSG00000118242.14,MREGLGGAxitinibEAG9.2385e-080.2459image
chr2:215943536-215944339:-LGGAxitinibEER9.0675e-080.2460image
chr2:216030626-216031370:-LIHCBIRB.0796EER4.5688e-02-0.4515image
chr2:215943536-215944339:-LIHCFTI.277EER1.3720e-030.2076image
ENSG00000118242.14,MREGLIHCJNK.Inhibitor.VIIIEAG2.0215e-05-0.2660image
ENSG00000118242.14,MREGLUADJNK.Inhibitor.VIIIEAG1.2471e-12-0.3104image
chr2:215943536-215944339:-LUADJNK.Inhibitor.VIIIEER1.9897e-13-0.3211image
ENSG00000118242.14,MREGLUSCGemcitabineEAG8.2113e-14-0.3268image
chr2:215943536-215944339:-LUSCGemcitabineEER6.2638e-14-0.3283image
chr2:215943536-215944339:-MESOGefitinibEER4.5378e-03-0.3912image
ENSG00000118242.14,MREGMESOGefitinibEAG6.9904e-03-0.3732image
ENSG00000118242.14,MREGOVCytarabineEAG3.8738e-050.2424image
chr2:215943536-215944339:-OVCytarabineEER2.7926e-060.2748image
ENSG00000118242.14,MREGPAADBortezomibEAG9.8659e-03-0.2047image
chr2:215943536-215944339:-PAADAZD6244EER8.3249e-03-0.2093image
ENSG00000118242.14,MREGPCPGGSK269962AEAG1.4418e-050.3206image
chr2:215943536-215944339:-PCPGGSK269962AEER1.4261e-050.3207image
chr2:215943536-215944339:-PRADCMKEER1.2971e-02-0.2174image
ENSG00000118242.14,MREGPRADCMKEAG5.9086e-03-0.2393image
chr2:215943536-215944339:-READBIRB.0796EER3.1103e-020.2459image
ENSG00000118242.14,MREGREADBIRB.0796EAG3.1103e-020.2459image
chr2:215943536-215944339:-SARCFH535EER2.3660e-030.3735image
ENSG00000118242.14,MREGSARCFH535EAG2.3660e-030.3735image
ENSG00000118242.14,MREGSKCMDMOGEAG5.4151e-10-0.2824image
chr2:215943536-215944339:-SKCMJNK.9LEER8.3684e-10-0.2794image
ENSG00000118242.14,MREGSTADDasatinibEAG4.3032e-03-0.1800image
chr2:215943536-215944339:-STADDasatinibEER2.0627e-03-0.1975image
chr2:215943536-215944339:-TGCTKIN001.135EER3.8521e-080.4371image
ENSG00000118242.14,MREGTGCTFTI.277EAG6.5176e-080.4304image
chr2:215943536-215944339:-THCACI.1040EER4.3499e-12-0.3088image
ENSG00000118242.14,MREGTHCACI.1040EAG7.5921e-12-0.3055image
chr2:215943536-215944339:-THYMIPA.3EER5.1014e-110.6053image
ENSG00000118242.14,MREGTHYMIPA.3EAG5.0553e-110.6054image
chr2:215943536-215944339:-UCECJNK.Inhibitor.VIIIEER3.9253e-05-0.3153image
ENSG00000118242.14,MREGUCECA.443654EAG1.7707e-04-0.2887image
ENSG00000118242.14,MREGUCSBortezomibEAG2.0880e-03-0.4251image
chr2:215943536-215944339:-UCSBortezomibEER2.1253e-03-0.4245image
chr2:215943536-215944339:-UVMABT.888EER5.5854e-08-0.5687image
ENSG00000118242.14,MREGUVMABT.888EAG5.5854e-08-0.5687image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType