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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: GPATCH2L (ImmuneEditome ID:55668)

1. Gene summary of enriched editing regions for GPATCH2L

check button Gene summary
Gene informationGene symbol

GPATCH2L

Gene ID

55668

GeneSynonymsC14orf118
GeneCytomap

14q24.3

GeneTypeprotein-coding
GeneDescriptionG patch domain-containing protein 2-like
GeneModificationdate20230329
UniprotIDQ9NWQ4;G3V290;G3V3M4;G3V553;G3V5D0;G3V4L1
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr14:76205021-76205253:+ENST00000556675.2ENSG00000089916.16GPATCH2LncRNA_intronicAluJr4chr14:76205021-76205253:+.alignment
chr14:76207016-76207284:+ENST00000556675.2ENSG00000089916.16GPATCH2LncRNA_intronicAluJochr14:76207016-76207284:+.alignment


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2. Tumor-specific enriched editing regions for GPATCH2L


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr14:76207016-76207284:+BRCAEER6.1773e-04image
ENSG00000089916.16,GPATCH2LBRCAEAG2.6736e-05image
ENSG00000089916.16,GPATCH2LKIRCEAG1.0959e-03image
ENSG00000089916.16,GPATCH2LLUSCEAG2.6285e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000089916.16,GPATCH2LTGCTPathEAG5.4376e-032.2603e-030.4438image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
ENSG00000089916.16,GPATCH2LKIRCEAG2.3182e-023.7431e-021.7963e+01image
ENSG00000089916.16,GPATCH2LLUSCEAG9.3587e-038.9845e-034.1322e-02image

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3. Enriched editing regions and immune related genes for GPATCH2L


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr14:76207016-76207284:+ESCAEERENSG00000089916,GPATCH2L-0.37161.1520e-029.8755e-06-0.4009imageNELAVL1;HNRNPC;RBFOX2;RBM47NAT_cells_CD4_memory_restingGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION

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4. Enriched editing regions and immune related splicing for GPATCH2L


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr14:76207016-76207284:+
ESCAEERA3ENSG00000075624.9chr75530523:5530583:5528286:5528486:5528286:55287190.20722.6325e-023.0180e-050.4024imageNELAVL1;HNRNPC;RBFOX2;RBM47NAT_cells_gamma_deltaGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING

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5. Enriched editing regions and immune infiltration for GPATCH2L


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr14:76207016-76207284:+BRCAEERDendritic_cells_resting3.8332e-02-0.1129image
ENSG00000089916.16,GPATCH2LBRCAEAGT_cells_CD4_naive3.2024e-020.0895image
ENSG00000089916.16,GPATCH2LCESCEAGDendritic_cells_activated2.7743e-020.2690image
ENSG00000089916.16,GPATCH2LCOADEAGT_cells_CD4_memory_activated4.1307e-020.2712image
chr14:76207016-76207284:+ESCAEERT_cells_gamma_delta2.3435e-020.2122image
ENSG00000089916.16,GPATCH2LESCAEAGT_cells_gamma_delta2.9777e-030.2556image
ENSG00000089916.16,GPATCH2LHNSCEAGMonocytes1.3049e-020.1996image
ENSG00000089916.16,GPATCH2LKICHEAGNeutrophils2.1152e-020.3506image
ENSG00000089916.16,GPATCH2LKIRCEAGMonocytes2.4703e-020.1511image
ENSG00000089916.16,GPATCH2LKIRPEAGT_cells_CD4_memory_activated6.3784e-030.3063image
chr14:76207016-76207284:+LGGEERDendritic_cells_resting2.1466e-03-0.1686image
ENSG00000089916.16,GPATCH2LLGGEAGT_cells_gamma_delta2.1194e-02-0.1165image
ENSG00000089916.16,GPATCH2LLUADEAGNK_cells_resting2.7475e-030.2531image
ENSG00000089916.16,GPATCH2LLUSCEAGB_cells_memory3.4198e-020.1602image
chr14:76207016-76207284:+PCPGEERT_cells_CD4_memory_activated1.0774e-030.6621image
ENSG00000089916.16,GPATCH2LPCPGEAGT_cells_CD83.9444e-030.4953image
ENSG00000089916.16,GPATCH2LPRADEAGB_cells_memory4.4042e-020.1459image
ENSG00000089916.16,GPATCH2LSARCEAGNK_cells_resting4.1413e-02-0.1827image
ENSG00000089916.16,GPATCH2LSKCMEAGMonocytes2.3340e-020.1449image
chr14:76207016-76207284:+STADEERT_cells_follicular_helper1.4854e-020.1979image
ENSG00000089916.16,GPATCH2LSTADEAGT_cells_follicular_helper6.7509e-030.1860image
ENSG00000089916.16,GPATCH2LTGCTEAGMast_cells_resting3.4326e-020.2259image
ENSG00000089916.16,GPATCH2LTHCAEAGT_cells_CD83.6411e-020.1830image
ENSG00000089916.16,GPATCH2LTHYMEAGT_cells_follicular_helper3.4624e-03-0.3809image
ENSG00000089916.16,GPATCH2LUCECEAGT_cells_CD4_memory_activated8.6625e-030.4254image


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6. Enriched editing regions and immune gene sets for GPATCH2L


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000089916.16,GPATCH2LBLCAGSVA_HALLMARK_APICAL_SURFACEEAG1.9858e-020.3133image
ENSG00000089916.16,GPATCH2LBRCAGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG1.9123e-050.1774image
chr14:76207016-76207284:+BRCAGSVA_HALLMARK_DNA_REPAIREER1.9427e-020.1273image
ENSG00000089916.16,GPATCH2LCESCGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG7.6490e-030.3231image
ENSG00000089916.16,GPATCH2LCOADGSVA_HALLMARK_P53_PATHWAYEAG2.6289e-050.5261image
ENSG00000089916.16,GPATCH2LESCAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG5.1257e-030.2414image
chr14:76205021-76205253:+ESCAGSVA_HALLMARK_SPERMATOGENESISEER4.7002e-020.1943image
chr14:76207016-76207284:+ESCAGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.3644e-02-0.2304image
ENSG00000089916.16,GPATCH2LGBMGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG3.8108e-02-0.2754image
ENSG00000089916.16,GPATCH2LHNSCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG7.0242e-040.2702image
ENSG00000089916.16,GPATCH2LKIRCGSVA_HALLMARK_GLYCOLYSISEAG1.8001e-050.2841image
chr14:76207016-76207284:+LGGGSVA_HALLMARK_MITOTIC_SPINDLEEER9.7234e-06-0.2412image
ENSG00000089916.16,GPATCH2LLGGGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.0115e-04-0.1869image
ENSG00000089916.16,GPATCH2LLUADGSVA_HALLMARK_MYOGENESISEAG1.6183e-02-0.2044image
ENSG00000089916.16,GPATCH2LPAADGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG5.5513e-03-0.4112image
ENSG00000089916.16,GPATCH2LPCPGGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG4.7804e-02-0.3526image
chr14:76207016-76207284:+PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER7.4237e-030.5665image
ENSG00000089916.16,GPATCH2LPRADGSVA_HALLMARK_MYC_TARGETS_V1EAG5.9132e-030.1985image
ENSG00000089916.16,GPATCH2LREADGSVA_HALLMARK_UV_RESPONSE_DNEAG5.7041e-04-0.6877image
ENSG00000089916.16,GPATCH2LSARCGSVA_HALLMARK_UV_RESPONSE_DNEAG3.2168e-030.2615image
chr14:76207016-76207284:+SARCGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER1.4577e-030.2999image
ENSG00000089916.16,GPATCH2LSTADGSVA_HALLMARK_UV_RESPONSE_DNEAG2.0472e-04-0.2530image
chr14:76207016-76207284:+STADGSVA_HALLMARK_UV_RESPONSE_DNEER6.8145e-06-0.3570image
ENSG00000089916.16,GPATCH2LTHYMGSVA_HALLMARK_PROTEIN_SECRETIONEAG4.4878e-030.3711image


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7. Enriched editing regions and drugs for GPATCH2L


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000089916.16,GPATCH2LBLCAImatinibEAG1.4696e-03-0.4186image
ENSG00000089916.16,GPATCH2LBRCABicalutamideEAG2.0083e-02-0.0971image
ENSG00000089916.16,GPATCH2LCESCAxitinibEAG5.1224e-030.3382image
ENSG00000089916.16,GPATCH2LCOADAKT.inhibitor.VIIIEAG1.1642e-020.3320image
ENSG00000089916.16,GPATCH2LESCABMS.536924EAG9.4309e-03-0.2243image
chr14:76205021-76205253:+ESCADocetaxelEER1.5708e-02-0.2352image
chr14:76207016-76207284:+ESCAAZD.2281EER7.8801e-03-0.2477image
ENSG00000089916.16,GPATCH2LGBMBIRB.0796EAG1.2446e-020.3290image
ENSG00000089916.16,GPATCH2LHNSCBortezomibEAG3.3919e-04-0.2851image
ENSG00000089916.16,GPATCH2LKICHCI.1040EAG1.6762e-03-0.4651image
ENSG00000089916.16,GPATCH2LKIRCErlotinibEAG3.0832e-03-0.1982image
ENSG00000089916.16,GPATCH2LKIRPBI.D1870EAG5.1705e-04-0.3841image
ENSG00000089916.16,GPATCH2LLAMLA.443654EAG3.8486e-02-0.1790image
chr14:76207016-76207284:+LGGGNF.2EER3.2870e-07-0.2770image
ENSG00000089916.16,GPATCH2LLGGBosutinibEAG1.7864e-060.2388image
ENSG00000089916.16,GPATCH2LLUADAKT.inhibitor.VIIIEAG4.8206e-02-0.1685image
ENSG00000089916.16,GPATCH2LLUSCCytarabineEAG2.8572e-040.2710image
ENSG00000089916.16,GPATCH2LOVAZD6482EAG1.7988e-030.3319image
ENSG00000089916.16,GPATCH2LPCPGDMOGEAG1.0427e-02-0.4464image
chr14:76207016-76207284:+PCPGJNK.9LEER4.5879e-06-0.8232image
ENSG00000089916.16,GPATCH2LPRADBryostatin.1EAG1.2768e-020.1799image
ENSG00000089916.16,GPATCH2LREADKIN001.135EAG8.4526e-040.6722image
ENSG00000089916.16,GPATCH2LSARCImatinibEAG4.5344e-03-0.2523image
chr14:76207016-76207284:+SARCImatinibEER3.3538e-02-0.2029image
ENSG00000089916.16,GPATCH2LSKCMGefitinibEAG1.5467e-030.2016image
ENSG00000089916.16,GPATCH2LSTADAS601245EAG5.3872e-050.2743image
chr14:76207016-76207284:+STADAS601245EER4.2834e-050.3265image
ENSG00000089916.16,GPATCH2LTGCTJNK.9LEAG3.4467e-02-0.2257image
ENSG00000089916.16,GPATCH2LTHCAEmbelinEAG9.8611e-030.2247image
ENSG00000089916.16,GPATCH2LTHYMBMS.509744EAG4.5282e-020.2663image
ENSG00000089916.16,GPATCH2LUCECJNJ.26854165EAG1.6827e-030.4986image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType