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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: NPLOC4 (ImmuneEditome ID:55666)

1. Gene summary of enriched editing regions for NPLOC4

check button Gene summary
Gene informationGene symbol

NPLOC4

Gene ID

55666

GeneSynonymsNPL4
GeneCytomap

17q25.3

GeneTypeprotein-coding
GeneDescriptionnuclear protein localization protein 4 homolog|NPLOC4 ubiquitin recognition factor|nuclear protein localization 4 homolog
GeneModificationdate20230409
UniprotIDQ8TAT6;A0A024R8R4;K7EJN1;A0A0D9SFI9;I3L283;I3L4U9;I3L3I1
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr17:81559791-81564397:-ENST00000571714.4ENSG00000182446.12NPLOC4exonicL1PA16,AluSx1,L1PA17,(AAAC)n,(AC)n,AluSz,L1M5,L1P5,AluSc,AluJb,AluJr4,AluJo,AluSxchr17:81559791-81564397:-.alignment
chr17:81559791-81564397:-ENST00000573212.4ENSG00000182446.12NPLOC4exonicL1PA16,AluSx1,L1PA17,(AAAC)n,(AC)n,AluSz,L1M5,L1P5,AluSc,AluJb,AluJr4,AluJo,AluSxchr17:81559791-81564397:-.alignment
chr17:81559791-81564397:-ENST00000573519.4ENSG00000182446.12NPLOC4exonicL1PA16,AluSx1,L1PA17,(AAAC)n,(AC)n,AluSz,L1M5,L1P5,AluSc,AluJb,AluJr4,AluJo,AluSxchr17:81559791-81564397:-.alignment
chr17:81628366-81629379:-ENST00000570300.1ENSG00000182446.12NPLOC4ncRNA_intronicAluY,L1MEf,AluSg7chr17:81628366-81629379:-.alignment
chr17:81632198-81632522:-ENST00000570300.1ENSG00000182446.12NPLOC4ncRNA_intronicAluSq2,L1M4c,AluSxchr17:81632198-81632522:-.alignment


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2. Tumor-specific enriched editing regions for NPLOC4


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr17:81559791-81564397:-UCECCliEER4.1426e-022.2676e-02-0.1459image
ENSG00000182446.12,NPLOC4UCECCliEAG4.5971e-022.4687e-02-0.1432image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr17:81559791-81564397:-ACCEER1.3573e-025.8129e-031.5212e+05image
ENSG00000182446.12,NPLOC4ACCEAG1.3573e-025.8129e-031.5212e+05image
chr17:81559791-81564397:-STADEER2.2502e-033.0209e-037.8698e+01image
ENSG00000182446.12,NPLOC4STADEAG4.4096e-032.2005e-038.9609e+01image

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3. Enriched editing regions and immune related genes for NPLOC4


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr17:81559791-81564397:-LAMLEERENSG00000071082,RPL310.42647.6917e-031.1177e-070.4390imageNNNANK_cells_activatedGSVA_HALLMARK_COMPLEMENT
chr17:81559791-81564397:-OVEERENSG00000135441,BLOC1S10.34383.9949e-062.2293e-130.4225imageNNBLOC1S1T_cells_CD8GSVA_HALLMARK_UV_RESPONSE_DN
chr17:81559791-81564397:-OVEERENSG00000188243,COMMD60.34195.9269e-061.2115e-180.4972imageNNNAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
chr17:81559791-81564397:-OVEERENSG00000136942,RPL350.33411.0517e-051.6280e-140.4403imageNNNAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
chr17:81559791-81564397:-OVEERENSG00000170889,RPS90.32761.5937e-052.4570e-140.4376imageNNNAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
chr17:81559791-81564397:-OVEERENSG00000168894,RNF1810.31912.8763e-051.2700e-120.4101imageNNNAT_cells_CD8GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr17:81559791-81564397:-OVEERENSG00000213598,RP11-112J1.10.31743.8271e-053.0601e-150.4511imageNNNAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
chr17:81559791-81564397:-OVEERENSG00000166228,PCBD10.30436.3870e-053.3979e-120.4029imageNNNAB_cells_memoryGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr17:81559791-81564397:-OVEERENSG00000213741,RPS290.30341.0079e-048.7616e-130.4128imageNNNANK_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr17:81559791-81564397:-OVEERENSG00000228474,OST40.29621.0868e-043.3132e-120.4031imageNNNAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
chr17:81559791-81564397:-LAMLEERENSG00000071082,RPL310.42647.6917e-031.1177e-070.4390imageNNNANK_cells_activatedGSVA_HALLMARK_COMPLEMENT
chr17:81559791-81564397:-OVEERENSG00000135441,BLOC1S10.34383.9949e-062.2293e-130.4225imageNNBLOC1S1T_cells_CD8GSVA_HALLMARK_UV_RESPONSE_DN
chr17:81559791-81564397:-OVEERENSG00000188243,COMMD60.34195.9269e-061.2115e-180.4972imageNNNAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
chr17:81559791-81564397:-OVEERENSG00000136942,RPL350.33411.0517e-051.6280e-140.4403imageNNNAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
chr17:81559791-81564397:-OVEERENSG00000170889,RPS90.32761.5937e-052.4570e-140.4376imageNNNAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
chr17:81559791-81564397:-OVEERENSG00000168894,RNF1810.31912.8763e-051.2700e-120.4101imageNNNAT_cells_CD8GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr17:81559791-81564397:-OVEERENSG00000213598,RP11-112J1.10.31743.8271e-053.0601e-150.4511imageNNNAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
chr17:81559791-81564397:-OVEERENSG00000166228,PCBD10.30436.3870e-053.3979e-120.4029imageNNNAB_cells_memoryGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr17:81559791-81564397:-OVEERENSG00000213741,RPS290.30341.0079e-048.7616e-130.4128imageNNNANK_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr17:81559791-81564397:-OVEERENSG00000228474,OST40.29621.0868e-043.3132e-120.4031imageNNNAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
chr17:81559791-81564397:-LAMLEERENSG00000071082,RPL310.42647.6917e-031.1177e-070.4390imageNNNANK_cells_activatedGSVA_HALLMARK_COMPLEMENT
chr17:81559791-81564397:-OVEERENSG00000135441,BLOC1S10.34383.9949e-062.2293e-130.4225imageNNBLOC1S1T_cells_CD8GSVA_HALLMARK_UV_RESPONSE_DN
chr17:81559791-81564397:-OVEERENSG00000188243,COMMD60.34195.9269e-061.2115e-180.4972imageNNNAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
chr17:81559791-81564397:-OVEERENSG00000136942,RPL350.33411.0517e-051.6280e-140.4403imageNNNAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
chr17:81559791-81564397:-OVEERENSG00000170889,RPS90.32761.5937e-052.4570e-140.4376imageNNNAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
chr17:81559791-81564397:-OVEERENSG00000168894,RNF1810.31912.8763e-051.2700e-120.4101imageNNNAT_cells_CD8GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr17:81559791-81564397:-OVEERENSG00000213598,RP11-112J1.10.31743.8271e-053.0601e-150.4511imageNNNAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
chr17:81559791-81564397:-OVEERENSG00000166228,PCBD10.30436.3870e-053.3979e-120.4029imageNNNAB_cells_memoryGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr17:81559791-81564397:-OVEERENSG00000213741,RPS290.30341.0079e-048.7616e-130.4128imageNNNANK_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr17:81559791-81564397:-OVEERENSG00000228474,OST40.29621.0868e-043.3132e-120.4031imageNNNAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE

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4. Enriched editing regions and immune related splicing for NPLOC4


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000182446.12,NPLOC4
KIRCEAGIRENSG00000041357.11chr1578540734:78540835:78541904:78541930-0.35666.0399e-098.2575e-13-0.4508imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CBX7;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184PSMA4Dendritic_cells_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr17:81559791-81564397:-
KIRCEERIRENSG00000122386.6chr163112559:3112682:3113348:3113487-0.37562.7366e-104.0595e-13-0.4626imageNNNAT_cells_follicular_helperGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr17:81559791-81564397:-
KIRCEERIRENSG00000106404.9chr7101232603:101232914:101234277:101234373-0.31964.7163e-063.7059e-11-0.4018imageNNCLDN15T_cells_follicular_helperGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr17:81559791-81564397:-
KIRCEERIRENSG00000072818.7chr177346243:7348475:7348994:7349167-0.29574.9258e-062.2745e-10-0.4100imageNNACAP1Macrophages_M2GSVA_HALLMARK_UV_RESPONSE_UP
chr17:81559791-81564397:-
KIRCEERIRENSG00000102312.16chrX48511891:48511935:48512325:48512497-0.33259.6413e-089.1689e-11-0.4308imageNNNAMast_cells_restingGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr17:81559791-81564397:-
KIRCEERIRENSG00000129968.11chr191877507:1877647:1879920:1880017-0.35886.0893e-077.1526e-12-0.4048imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000182446.12,NPLOC4
KIRCEAGIRENSG00000139636.11chr1249100387:49100646:49101249:49101263-0.36784.2888e-078.2800e-13-0.4167imageNACIN1;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184LMBR1LMacrophages_M1GSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000182446.12,NPLOC4
KIRCEAGIRENSG00000143569.14chr1154268756:154268954:154270199:154270564-0.35442.1952e-065.8589e-13-0.4192imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CBX7;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL1;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;WTAP;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAMacrophages_M2GSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000182446.12,NPLOC4
KIRCEAGIRENSG00000187954.8chr8144453221:144453460:144462282:144462415-0.38692.9657e-085.3867e-13-0.4241imageNADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RBM5;RNF219;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;WTAP;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAT_cells_follicular_helperGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000182446.12,NPLOC4
KIRCEAGIRENSG00000135437.5chr1255720412:55720517:55721147:55721494-0.29922.3136e-063.8740e-10-0.4112imageNADAR;AIFM1;AUH;BUD13;CNBP;CSTF2T;DDX54;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;HNRNPUL1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;KHSRP;LIN28;LSM11;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;U2AF1;U2AF2;UPF1;YTHDF1;ZC3H7B;ZNF184NAMacrophages_M2GSVA_HALLMARK_CHOLESTEROL_HOMEOSTASIS

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5. Enriched editing regions and immune infiltration for NPLOC4


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr17:81559791-81564397:-BLCAEERNK_cells_activated4.1476e-040.1987image
ENSG00000182446.12,NPLOC4BLCAEAGNK_cells_activated4.3723e-040.1979image
chr17:81559791-81564397:-BRCAEERPlasma_cells1.3445e-020.0813image
ENSG00000182446.12,NPLOC4BRCAEAGPlasma_cells1.2598e-020.0820image
chr17:81559791-81564397:-COADEERT_cells_CD4_memory_activated2.9042e-020.1525image
ENSG00000182446.12,NPLOC4COADEAGT_cells_CD4_memory_activated4.3323e-020.1413image
chr17:81559791-81564397:-ESCAEERT_cells_gamma_delta6.1219e-030.2158image
ENSG00000182446.12,NPLOC4ESCAEAGT_cells_gamma_delta6.4782e-030.2144image
chr17:81559791-81564397:-GBMEERDendritic_cells_activated3.0676e-040.3571image
ENSG00000182446.12,NPLOC4GBMEAGDendritic_cells_activated3.0714e-040.3571image
chr17:81559791-81564397:-HNSCEERDendritic_cells_resting2.8278e-02-0.1302image
ENSG00000182446.12,NPLOC4HNSCEAGDendritic_cells_resting2.8382e-02-0.1301image
chr17:81559791-81564397:-KIRCEERDendritic_cells_activated4.6614e-020.1208image
ENSG00000182446.12,NPLOC4KIRCEAGDendritic_cells_activated4.1697e-020.1236image
chr17:81559791-81564397:-KIRPEERT_cells_CD81.2216e-030.2143image
ENSG00000182446.12,NPLOC4KIRPEAGT_cells_CD81.1921e-030.2147image
chr17:81559791-81564397:-LAMLEERMonocytes5.5129e-03-0.2385image
ENSG00000182446.12,NPLOC4LAMLEAGNK_cells_activated2.0113e-020.1970image
chr17:81559791-81564397:-LIHCEERMonocytes7.1928e-040.2321image
ENSG00000182446.12,NPLOC4LIHCEAGMonocytes7.4204e-040.2316image
chr17:81559791-81564397:-LUADEERT_cells_gamma_delta6.0908e-040.1613image
ENSG00000182446.12,NPLOC4LUADEAGT_cells_gamma_delta5.8694e-040.1618image
chr17:81559791-81564397:-MESOEERMast_cells_activated2.6723e-020.2909image
ENSG00000182446.12,NPLOC4MESOEAGMast_cells_activated2.6723e-020.2909image
chr17:81559791-81564397:-OVEEREosinophils4.6292e-040.2094image
ENSG00000182446.12,NPLOC4OVEAGEosinophils4.2598e-040.2107image
chr17:81559791-81564397:-PCPGEERB_cells_naive1.6828e-02-0.2829image
ENSG00000182446.12,NPLOC4PCPGEAGB_cells_naive1.6828e-02-0.2829image
chr17:81559791-81564397:-PRADEERT_cells_follicular_helper2.6904e-02-0.1311image
ENSG00000182446.12,NPLOC4PRADEAGT_cells_follicular_helper2.4304e-02-0.1334image
chr17:81559791-81564397:-READEERT_cells_follicular_helper3.2441e-02-0.2699image
ENSG00000182446.12,NPLOC4READEAGT_cells_follicular_helper3.2441e-02-0.2699image
chr17:81559791-81564397:-SARCEERNK_cells_activated2.9825e-020.2242image
ENSG00000182446.12,NPLOC4SARCEAGNK_cells_activated2.9825e-020.2242image
chr17:81559791-81564397:-SKCMEERT_cells_gamma_delta1.7520e-020.1301image
ENSG00000182446.12,NPLOC4SKCMEAGT_cells_gamma_delta1.7351e-020.1303image
chr17:81559791-81564397:-STADEERMacrophages_M04.7331e-04-0.1851image
ENSG00000182446.12,NPLOC4STADEAGMacrophages_M06.2115e-04-0.1813image
chr17:81559791-81564397:-TGCTEERB_cells_memory2.7612e-030.2557image
ENSG00000182446.12,NPLOC4TGCTEAGB_cells_memory2.7567e-030.2557image
chr17:81559791-81564397:-THCAEERMacrophages_M05.3984e-03-0.1517image
ENSG00000182446.12,NPLOC4THCAEAGMacrophages_M05.3984e-03-0.1517image
chr17:81559791-81564397:-THYMEERT_cells_gamma_delta2.5788e-02-0.3121image
ENSG00000182446.12,NPLOC4THYMEAGT_cells_gamma_delta2.5788e-02-0.3121image
chr17:81559791-81564397:-UCECEERDendritic_cells_activated4.5135e-020.1889image
chr17:81559791-81564397:-UVMEERT_cells_follicular_helper3.1939e-02-0.3861image
ENSG00000182446.12,NPLOC4UVMEAGT_cells_follicular_helper3.1939e-02-0.3861image


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6. Enriched editing regions and immune gene sets for NPLOC4


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000182446.12,NPLOC4ACCGSVA_HALLMARK_SPERMATOGENESISEAG3.3205e-02-0.3333image
chr17:81559791-81564397:-ACCGSVA_HALLMARK_SPERMATOGENESISEER3.3205e-02-0.3333image
ENSG00000182446.12,NPLOC4BLCAGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG6.9656e-050.2232image
chr17:81559791-81564397:-BLCAGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER5.7660e-050.2257image
ENSG00000182446.12,NPLOC4BRCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.9244e-100.2053image
chr17:81559791-81564397:-BRCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER5.1175e-100.2027image
chr17:81559791-81564397:-CESCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.7591e-030.1973image
ENSG00000182446.12,NPLOC4CESCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.5776e-030.1988image
ENSG00000182446.12,NPLOC4CHOLGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.7210e-020.4466image
chr17:81559791-81564397:-CHOLGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.7635e-020.4451image
ENSG00000182446.12,NPLOC4COADGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.0397e-02-0.1619image
chr17:81559791-81564397:-COADGSVA_HALLMARK_MYC_TARGETS_V1EER2.6043e-020.1554image
chr17:81559791-81564397:-ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER1.8281e-040.2916image
ENSG00000182446.12,NPLOC4ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG1.6832e-040.2932image
ENSG00000182446.12,NPLOC4GBMGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG2.6654e-030.3003image
chr17:81559791-81564397:-GBMGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER2.6998e-030.2999image
ENSG00000182446.12,NPLOC4HNSCGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG1.1462e-04-0.2269image
chr17:81559791-81564397:-HNSCGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER1.1311e-04-0.2271image
ENSG00000182446.12,NPLOC4KIRCGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG3.2053e-090.3492image
chr17:81559791-81564397:-KIRCGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER2.7742e-090.3505image
chr17:81559791-81564397:-KIRPGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.3940e-050.2852image
ENSG00000182446.12,NPLOC4KIRPGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.4245e-050.2849image
ENSG00000182446.12,NPLOC4LAMLGSVA_HALLMARK_MYC_TARGETS_V2EAG3.5068e-020.1789image
chr17:81559791-81564397:-LAMLGSVA_HALLMARK_MYC_TARGETS_V2EER1.4683e-020.2104image
chr17:81559791-81564397:-LIHCGSVA_HALLMARK_DNA_REPAIREER9.5830e-03-0.1788image
ENSG00000182446.12,NPLOC4LIHCGSVA_HALLMARK_DNA_REPAIREAG9.4430e-03-0.1792image
ENSG00000182446.12,NPLOC4LUADGSVA_HALLMARK_APOPTOSISEAG5.9240e-110.3028image
chr17:81559791-81564397:-LUADGSVA_HALLMARK_APOPTOSISEER6.1299e-110.3026image
chr17:81559791-81564397:-LUSCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER6.5153e-050.1867image
ENSG00000182446.12,NPLOC4LUSCGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG5.0973e-050.1894image
chr17:81559791-81564397:-MESOGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER4.3826e-03-0.3689image
ENSG00000182446.12,NPLOC4MESOGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG4.3826e-03-0.3689image
chr17:81559791-81564397:-OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.1406e-060.2880image
ENSG00000182446.12,NPLOC4OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.2787e-060.2867image
ENSG00000182446.12,NPLOC4PAADGSVA_HALLMARK_DNA_REPAIREAG6.0431e-03-0.2387image
chr17:81559791-81564397:-PAADGSVA_HALLMARK_DNA_REPAIREER6.0746e-03-0.2385image
ENSG00000182446.12,NPLOC4PRADGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.5907e-03-0.1674image
chr17:81559791-81564397:-PRADGSVA_HALLMARK_MITOTIC_SPINDLEEER5.3550e-03-0.1646image
ENSG00000182446.12,NPLOC4READGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG2.1230e-02-0.2898image
chr17:81559791-81564397:-READGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER2.1230e-02-0.2898image
ENSG00000182446.12,NPLOC4STADGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.7001e-03-0.1541image
chr17:81559791-81564397:-STADGSVA_HALLMARK_MITOTIC_SPINDLEEER3.3610e-03-0.1557image
chr17:81559791-81564397:-TGCTGSVA_HALLMARK_PANCREAS_BETA_CELLSEER2.4368e-050.3547image
ENSG00000182446.12,NPLOC4TGCTGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.4079e-050.3549image
chr17:81559791-81564397:-THCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER2.8211e-030.1627image
ENSG00000182446.12,NPLOC4THCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.8211e-030.1627image
ENSG00000182446.12,NPLOC4THYMGSVA_HALLMARK_MTORC1_SIGNALINGEAG2.4707e-02-0.3143image
chr17:81559791-81564397:-THYMGSVA_HALLMARK_MTORC1_SIGNALINGEER2.4707e-02-0.3143image
chr17:81559791-81564397:-UCSGSVA_HALLMARK_DNA_REPAIREER1.6346e-030.5420image
ENSG00000182446.12,NPLOC4UCSGSVA_HALLMARK_DNA_REPAIREAG1.6466e-030.5417image


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7. Enriched editing regions and drugs for NPLOC4


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr17:81559791-81564397:-BLCABMS.509744EER4.1533e-05-0.2299image
ENSG00000182446.12,NPLOC4BLCAA.770041EAG5.4655e-05-0.2264image
chr17:81559791-81564397:-BRCAMG.132EER8.8918e-06-0.1458image
ENSG00000182446.12,NPLOC4BRCAGSK269962AEAG7.0749e-06-0.1474image
ENSG00000182446.12,NPLOC4CESCCHIR.99021EAG2.3664e-020.1431image
chr17:81559791-81564397:-CESCCHIR.99021EER2.2354e-020.1447image
chr17:81559791-81564397:-CHOLDocetaxelEER1.8331e-02-0.4427image
ENSG00000182446.12,NPLOC4CHOLDocetaxelEAG1.9432e-02-0.4390image
chr17:81559791-81564397:-COADCisplatinEER8.1198e-04-0.2321image
ENSG00000182446.12,NPLOC4COADCisplatinEAG4.4859e-04-0.2429image
ENSG00000182446.12,NPLOC4DLBCDMOGEAG1.9831e-020.4456image
chr17:81559791-81564397:-DLBCDMOGEER1.9831e-020.4456image
chr17:81559791-81564397:-ESCACGP.60474EER1.3015e-05-0.3372image
ENSG00000182446.12,NPLOC4ESCACGP.60474EAG1.3973e-05-0.3360image
chr17:81559791-81564397:-GBMABT.888EER8.4196e-040.3319image
ENSG00000182446.12,NPLOC4GBMABT.888EAG7.8448e-040.3337image
ENSG00000182446.12,NPLOC4HNSCJNK.Inhibitor.VIIIEAG3.4237e-040.2110image
chr17:81559791-81564397:-HNSCJNK.Inhibitor.VIIIEER3.4151e-040.2111image
ENSG00000182446.12,NPLOC4KIRCBIRB.0796EAG1.1234e-040.2325image
chr17:81559791-81564397:-KIRCBIRB.0796EER9.3669e-050.2350image
chr17:81559791-81564397:-KIRPLFM.A13EER1.5738e-020.1608image
ENSG00000182446.12,NPLOC4KIRPLFM.A13EAG1.5984e-020.1605image
ENSG00000182446.12,NPLOC4LAMLDocetaxelEAG1.9826e-02-0.1974image
chr17:81559791-81564397:-LAMLDocetaxelEER2.5625e-03-0.2585image
ENSG00000182446.12,NPLOC4LGGJNK.Inhibitor.VIIIEAG4.3221e-020.1323image
chr17:81559791-81564397:-LGGJNK.Inhibitor.VIIIEER3.8745e-020.1355image
ENSG00000182446.12,NPLOC4LIHCBryostatin.1EAG7.3539e-03-0.1849image
chr17:81559791-81564397:-LIHCBryostatin.1EER7.4239e-03-0.1847image
ENSG00000182446.12,NPLOC4LUADBMS.509744EAG1.3072e-10-0.2975image
chr17:81559791-81564397:-LUADBMS.509744EER1.0431e-10-0.2991image
chr17:81559791-81564397:-LUSCBMS.509744EER6.4170e-08-0.2509image
ENSG00000182446.12,NPLOC4LUSCBMS.509744EAG5.1217e-08-0.2527image
ENSG00000182446.12,NPLOC4MESOABT.888EAG1.2443e-030.4138image
chr17:81559791-81564397:-MESOABT.888EER1.2443e-030.4138image
chr17:81559791-81564397:-OVA.770041EER4.3890e-11-0.3832image
ENSG00000182446.12,NPLOC4OVA.770041EAG5.9934e-11-0.3807image
ENSG00000182446.12,NPLOC4PAADGSK269962AEAG3.5769e-05-0.3554image
chr17:81559791-81564397:-PAADGSK269962AEER3.5879e-05-0.3554image
chr17:81559791-81564397:-PRADA.770041EER9.1630e-03-0.1541image
ENSG00000182446.12,NPLOC4PRADA.770041EAG9.9626e-03-0.1524image
chr17:81559791-81564397:-READJNJ.26854165EER1.8659e-030.3844image
ENSG00000182446.12,NPLOC4READJNJ.26854165EAG1.8659e-030.3844image
chr17:81559791-81564397:-SARCATRAEER3.1400e-020.2222image
ENSG00000182446.12,NPLOC4SARCATRAEAG3.1400e-020.2222image
chr17:81559791-81564397:-SKCMBMS.536924EER1.6985e-04-0.2053image
ENSG00000182446.12,NPLOC4SKCMBMS.536924EAG1.6649e-04-0.2055image
chr17:81559791-81564397:-STADGSK269962AEER7.5612e-04-0.1792image
ENSG00000182446.12,NPLOC4STADGSK269962AEAG4.5390e-04-0.1865image
ENSG00000182446.12,NPLOC4TGCTDasatinibEAG6.5793e-04-0.2896image
chr17:81559791-81564397:-TGCTDasatinibEER6.6604e-04-0.2893image
ENSG00000182446.12,NPLOC4THCACGP.082996EAG4.3142e-030.1556image
chr17:81559791-81564397:-THCACGP.082996EER4.3142e-030.1556image
ENSG00000182446.12,NPLOC4THYMAZD.2281EAG3.0024e-020.3041image
chr17:81559791-81564397:-THYMAZD.2281EER3.0024e-020.3041image
chr17:81559791-81564397:-UCECEmbelinEER3.5453e-020.1981image
ENSG00000182446.12,NPLOC4UCSGSK.650394EAG1.5339e-03-0.5447image
chr17:81559791-81564397:-UCSGSK.650394EER1.5453e-03-0.5444image
ENSG00000182446.12,NPLOC4UVMMG.132EAG5.5406e-04-0.5845image
chr17:81559791-81564397:-UVMMG.132EER5.5406e-04-0.5845image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType