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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: BCAS4 (ImmuneEditome ID:55653)

1. Gene summary of enriched editing regions for BCAS4

check button Gene summary
Gene informationGene symbol

BCAS4

Gene ID

55653

GeneSynonymsCNOL
GeneCytomap

20q13.13

GeneTypeprotein-coding
GeneDescriptionbreast carcinoma-amplified sequence 4|BCAS4/BCAS3 fusion|breast carcinoma amplified sequence 4/3 fusion protein
GeneModificationdate20230329
UniprotIDQ8TDM0;A0A804CEY2;A0A0C4DGS6;H7C4Y8;A0A0C4DH49
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr20:50877554-50882176:+ENST00000371608.5ENSG00000124243.16BCAS4UTR3AluSz6,FLAM_C,AluJo,AluSx,L1ME4b,AluJb,AluSz,L1ME3A,MIRchr20:50877554-50882176:+.alignment


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2. Tumor-specific enriched editing regions for BCAS4


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr20:50877554-50882176:+BRCAEER1.1930e-02image
ENSG00000124243.16,BCAS4BRCAEAG2.2252e-02image
chr20:50877554-50882176:+THCAEER2.6304e-02image
ENSG00000124243.16,BCAS4THCAEAG2.9136e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for BCAS4


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr20:50877554-50882176:+DLBCEERENSG00000169762,TAPT1-0.61112.8164e-025.8347e-03-0.4283imageNFUS;TAF15NAB_cells_naiveGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr20:50877554-50882176:+DLBCEERENSG00000145901,TNIP10.57792.9323e-029.8431e-050.5766imageNFUS;TAF15TNIP1Dendritic_cells_activatedGSVA_HALLMARK_MYC_TARGETS_V2
chr20:50877554-50882176:+DLBCEERENSG00000087088,BAX0.58723.5147e-027.4066e-030.4172imageNFUS;TAF15BAXB_cells_naiveGSVA_HALLMARK_TGF_BETA_SIGNALING
chr20:50877554-50882176:+DLBCEERENSG00000167778,SPRYD30.57293.6235e-022.6252e-030.4630imageNFUS;TAF15NAGSVA_HALLMARK_APICAL_SURFACE
chr20:50877554-50882176:+DLBCEERENSG00000099822,HCN2-0.58813.9279e-022.0926e-03-0.4723imageNFUS;TAF15NAB_cells_naiveGSVA_HALLMARK_IL2_STAT5_SIGNALING
chr20:50877554-50882176:+DLBCEERENSG00000214595,EML6-0.57744.1954e-025.6893e-03-0.4294imageNFUS;TAF15NAMast_cells_activatedGSVA_HALLMARK_PANCREAS_BETA_CELLS

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4. Enriched editing regions and immune related splicing for BCAS4


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000124243.16,BCAS4
GBMEAGESENSG00000146833.11chr799909564:99909660:99917771:99917885:99919008:99919105-0.26863.2691e-022.5480e-07-0.4010imageNACIN1;ADAR;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FBL;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;IGF2BP2;KHDRBS2;LARP4B;LIN28A;MOV10;MSI1;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RBFOX2;SLTM;TAF15;TARDBP;TIA1;TIAL1;TROVE2;U2AF2;UPF1NAT_cells_gamma_deltaGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
ENSG00000124243.16,BCAS4
GBMEAGIRENSG00000131148.4chr1685778623:85779867:85781210:85781258-0.35001.7099e-023.7920e-09-0.4448imageNADAR;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;EWSR1;FBL;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;IGF2BP2;KHDRBS2;LARP4B;LIN28A;MOV10;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RBFOX2;SLTM;TAF15;TARDBP;TIA1;TIAL1;TROVE2;U2AF2;UPF1NAT_cells_follicular_helperGSVA_HALLMARK_APOPTOSIS
ENSG00000124243.16,BCAS4
GBMEAGA3ENSG00000111731.8chr1222523425:22523622:22518095:22518137:22518095:225192390.26203.3840e-027.3706e-090.4661imageNACIN1;ADAR;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FBL;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;IGF2BP2;KHDRBS2;LIN28A;MOV10;MSI1;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RBFOX2;TAF15;TARDBP;TIA1;TIAL1;TROVE2;U2AF2;UPF1NAMacrophages_M2GSVA_HALLMARK_KRAS_SIGNALING_DN
ENSG00000124243.16,BCAS4
GBMEAGIRENSG00000111247.10chr124556352:4556502:4558856:4558968-0.30553.4257e-023.2409e-07-0.4158imageNACIN1;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;EWSR1;FBL;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;IGF2BP2;KHDRBS2;LARP4B;LIN28A;MOV10;MSI1;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RBFOX2;SLTM;TAF15;TARDBP;TIA1;TIAL1;TROVE2;U2AF2;UPF1NAMacrophages_M2GSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
ENSG00000124243.16,BCAS4
GBMEAGA3ENSG00000143106.8chr1109426301:109426351:109415236:109415350:109415236:109415363-0.12769.2934e-031.2980e-10-0.5332imageNACIN1;ADAR;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FBL;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;IGF2BP2;KHDRBS2;LARP4B;LIN28A;MOV10;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RBFOX2;SLTM;TAF15;TARDBP;TIA1;TIAL1;TROVE2;U2AF2;UPF1PSMA5GSVA_HALLMARK_KRAS_SIGNALING_DN
ENSG00000124243.16,BCAS4
GBMEAGIRENSG00000139278.5chr1275495576:75495662:75498693:75498717-0.43247.1005e-046.1704e-08-0.4109imageNADAR;DKC1;EIF4A3;ELAVL1;ELAVL3;FMR1;FUS;HNRNPC;HNRNPL;IGF2BP2;KHDRBS2;MOV10;MSI1;NOP56;PTBP1;RBFOX2;TAF15;TIA1;TIAL1;UPF1NAMonocytesGSVA_HALLMARK_COAGULATION
ENSG00000124243.16,BCAS4
GBMEAGIRENSG00000162576.12chr11352688:1353928:1354029:1354102-0.43187.1765e-042.8610e-12-0.5147imageNADAR;CSTF2T;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;FBL;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;MOV10;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RBFOX2;SLTM;TAF15;TARDBP;TIA1;TROVE2;U2AF2;UPF1NAT_cells_CD4_naiveGSVA_HALLMARK_APOPTOSIS
ENSG00000124243.16,BCAS4
GBMEAGESENSG00000130779.15chr12122341087:122341697:122347374:122347479:122352725:122352782-0.34051.5185e-036.4891e-09-0.4992imageNACIN1;ADAR;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FBL;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;IGF2BP2;KHDRBS2;LARP4B;LIN28A;MOV10;MSI1;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RBFOX2;SLTM;TAF15;TARDBP;TIA1;TIAL1;TROVE2;U2AF2;UPF1;WTAPCLIP1Mast_cells_restingGSVA_HALLMARK_SPERMATOGENESIS
ENSG00000124243.16,BCAS4
GBMEAGESENSG00000182667.10chr11132314551:132314703:132330152:132330185:132335045:1323350510.30683.5379e-024.3234e-070.4051imageNADAR;CNBP;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FBL;FMR1;FUS;HNRNPA1;HNRNPC;HNRNPL;HNRNPM;IGF2BP2;MOV10;MSI1;NOP56;NOP58;PCBP2;PTBP1;RBFOX2;TAF15;TARDBP;TROVE2;U2AF2;UPF1;WTAPNTMT_cells_follicular_helperGSVA_HALLMARK_SPERMATOGENESIS
ENSG00000124243.16,BCAS4
GBMEAGESENSG00000138443.11chr2203395658:203395780:203396784:203396967:203402575:203402677-0.36523.6156e-036.4737e-10-0.4626imageNACIN1;ADAR;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FBL;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;IGF2BP2;KHDRBS2;LARP4B;LIN28A;MOV10;MSI1;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RBFOX2;SLTM;TAF15;TARDBP;TIA1;TIAL1;TROVE2;U2AF2;UPF1;WTAPNAT_cells_gamma_deltaGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE

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5. Enriched editing regions and immune infiltration for BCAS4


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr20:50877554-50882176:+BLCAEERNK_cells_resting7.6259e-030.2765image
ENSG00000124243.16,BCAS4BLCAEAGNK_cells_resting5.7504e-030.2813image
chr20:50877554-50882176:+CESCEERDendritic_cells_activated2.2009e-020.3612image
ENSG00000124243.16,BCAS4CESCEAGDendritic_cells_activated2.2009e-020.3612image
chr20:50877554-50882176:+ESCAEERMacrophages_M01.1149e-02-0.2773image
ENSG00000124243.16,BCAS4ESCAEAGMacrophages_M21.3039e-030.3393image
ENSG00000124243.16,BCAS4GBMEAGMacrophages_M02.9980e-03-0.2325image
chr20:50877554-50882176:+HNSCEERT_cells_CD4_memory_activated1.0770e-020.3808image
ENSG00000124243.16,BCAS4HNSCEAGT_cells_CD4_memory_activated1.6556e-020.3516image
chr20:50877554-50882176:+KICHEERMacrophages_M19.9707e-030.3224image
ENSG00000124243.16,BCAS4KICHEAGMacrophages_M19.9707e-030.3224image
ENSG00000124243.16,BCAS4KIRCEAGMacrophages_M22.7212e-020.2900image
chr20:50877554-50882176:+KIRPEERMacrophages_M12.0618e-020.2479image
ENSG00000124243.16,BCAS4KIRPEAGMacrophages_M12.0618e-020.2479image
chr20:50877554-50882176:+LGGEERMacrophages_M23.8204e-030.2182image
ENSG00000124243.16,BCAS4LGGEAGMacrophages_M23.8204e-030.2182image
chr20:50877554-50882176:+LUADEERT_cells_regulatory_(Tregs)1.4987e-030.2940image
ENSG00000124243.16,BCAS4LUADEAGT_cells_CD81.6167e-020.2201image
chr20:50877554-50882176:+LUSCEERDendritic_cells_activated3.1376e-020.1896image
ENSG00000124243.16,BCAS4LUSCEAGMacrophages_M02.7155e-02-0.1916image
chr20:50877554-50882176:+OVEEREosinophils1.6006e-060.4094image
chr20:50877554-50882176:+PCPGEEREosinophils2.3760e-020.3711image
ENSG00000124243.16,BCAS4PCPGEAGEosinophils2.3760e-020.3711image
ENSG00000124243.16,BCAS4PRADEAGEosinophils2.2404e-030.3291image
chr20:50877554-50882176:+SARCEERPlasma_cells2.9364e-020.3634image
ENSG00000124243.16,BCAS4SARCEAGPlasma_cells1.4689e-020.3615image
chr20:50877554-50882176:+SKCMEERT_cells_CD84.3441e-02-0.2897image
ENSG00000124243.16,BCAS4SKCMEAGDendritic_cells_resting6.4450e-030.3803image
chr20:50877554-50882176:+STADEERDendritic_cells_resting1.1236e-030.2635image
ENSG00000124243.16,BCAS4STADEAGT_cells_CD4_memory_activated7.9259e-040.2572image
chr20:50877554-50882176:+THCAEERNK_cells_resting6.0304e-030.1357image
ENSG00000124243.16,BCAS4THCAEAGNK_cells_resting8.2267e-030.1307image
chr20:50877554-50882176:+THYMEERT_cells_CD81.9954e-02-0.2665image
ENSG00000124243.16,BCAS4THYMEAGT_cells_CD82.9392e-02-0.2500image
ENSG00000124243.16,BCAS4UCSEAGT_cells_CD4_memory_activated2.7232e-020.4812image


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6. Enriched editing regions and immune gene sets for BCAS4


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr20:50877554-50882176:+BRCAGSVA_HALLMARK_HYPOXIAEER3.5560e-030.1177image
ENSG00000124243.16,BCAS4BRCAGSVA_HALLMARK_NOTCH_SIGNALINGEAG1.3381e-020.0991image
ENSG00000124243.16,BCAS4DLBCGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.3525e-02-0.3169image
chr20:50877554-50882176:+ESCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER3.4493e-020.2324image
chr20:50877554-50882176:+GBMGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER4.6592e-030.3938image
ENSG00000124243.16,BCAS4GBMGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG8.8639e-090.4340image
ENSG00000124243.16,BCAS4HNSCGSVA_HALLMARK_MYC_TARGETS_V1EAG1.3657e-030.4582image
chr20:50877554-50882176:+HNSCGSVA_HALLMARK_MYC_TARGETS_V1EER1.0613e-020.3815image
ENSG00000124243.16,BCAS4KICHGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG3.9944e-02-0.2596image
chr20:50877554-50882176:+KICHGSVA_HALLMARK_TGF_BETA_SIGNALINGEER3.9944e-02-0.2596image
chr20:50877554-50882176:+KIRPGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER2.8096e-02-0.2355image
ENSG00000124243.16,BCAS4KIRPGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG2.8096e-02-0.2355image
chr20:50877554-50882176:+LGGGSVA_HALLMARK_E2F_TARGETSEER4.7203e-040.2623image
ENSG00000124243.16,BCAS4LGGGSVA_HALLMARK_E2F_TARGETSEAG4.7203e-040.2623image
ENSG00000124243.16,BCAS4LUADGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG2.3188e-040.3314image
chr20:50877554-50882176:+LUADGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER1.1414e-030.3009image
ENSG00000124243.16,BCAS4LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.5710e-030.2445image
chr20:50877554-50882176:+LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER6.2570e-030.2395image
ENSG00000124243.16,BCAS4OVGSVA_HALLMARK_UV_RESPONSE_DNEAG9.4106e-04-0.2728image
chr20:50877554-50882176:+OVGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER2.0031e-020.2054image
ENSG00000124243.16,BCAS4PAADGSVA_HALLMARK_NOTCH_SIGNALINGEAG2.3049e-020.4441image
chr20:50877554-50882176:+PAADGSVA_HALLMARK_NOTCH_SIGNALINGEER2.5565e-020.4457image
chr20:50877554-50882176:+PCPGGSVA_HALLMARK_COAGULATIONEER4.8392e-060.6739image
ENSG00000124243.16,BCAS4PCPGGSVA_HALLMARK_COAGULATIONEAG4.8392e-060.6739image
chr20:50877554-50882176:+PRADGSVA_HALLMARK_SPERMATOGENESISEER8.9117e-03-0.2854image
ENSG00000124243.16,BCAS4PRADGSVA_HALLMARK_SPERMATOGENESISEAG1.2134e-03-0.3472image
chr20:50877554-50882176:+SARCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER2.5384e-02-0.3722image
ENSG00000124243.16,BCAS4SARCGSVA_HALLMARK_ADIPOGENESISEAG2.9802e-020.3242image
ENSG00000124243.16,BCAS4SKCMGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.9705e-02-0.2919image
ENSG00000124243.16,BCAS4STADGSVA_HALLMARK_BILE_ACID_METABOLISMEAG9.7456e-03-0.1995image
ENSG00000124243.16,BCAS4THCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG9.8682e-05-0.1916image
chr20:50877554-50882176:+THCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER6.3998e-05-0.1966image
ENSG00000124243.16,BCAS4UCSGSVA_HALLMARK_DNA_REPAIREAG8.4080e-03-0.5592image


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7. Enriched editing regions and drugs for BCAS4


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000124243.16,BCAS4BLCAIPA.3EAG1.0960e-020.2599image
chr20:50877554-50882176:+BLCAElesclomolEER9.1313e-030.2704image
chr20:50877554-50882176:+BRCAJNK.Inhibitor.VIIIEER7.2376e-040.1364image
ENSG00000124243.16,BCAS4BRCAAUY922EAG6.5790e-03-0.1088image
chr20:50877554-50882176:+CESCA.770041EER1.6146e-03-0.4825image
ENSG00000124243.16,BCAS4CESCA.770041EAG1.6146e-03-0.4825image
ENSG00000124243.16,BCAS4COADBMS.754807EAG1.7276e-02-0.4117image
chr20:50877554-50882176:+DLBCBMS.536924EER1.0216e-02-0.4016image
ENSG00000124243.16,BCAS4DLBCBMS.536924EAG1.2319e-02-0.3875image
chr20:50877554-50882176:+ESCAMetforminEER8.6852e-03-0.2863image
ENSG00000124243.16,BCAS4ESCABIRB.0796EAG2.9084e-020.2341image
chr20:50877554-50882176:+GBMKU.55933EER5.8400e-03-0.3845image
ENSG00000124243.16,BCAS4GBMCyclopamineEAG8.6470e-09-0.4343image
ENSG00000124243.16,BCAS4HNSCGDC0941EAG1.2485e-030.4614image
chr20:50877554-50882176:+HNSCErlotinibEER2.0378e-04-0.5317image
ENSG00000124243.16,BCAS4KICHLapatinibEAG1.7441e-020.2986image
chr20:50877554-50882176:+KICHLapatinibEER1.7441e-020.2986image
ENSG00000124243.16,BCAS4KIRCErlotinibEAG2.3184e-02-0.2978image
chr20:50877554-50882176:+KIRCErlotinibEER3.6486e-03-0.3758image
chr20:50877554-50882176:+KIRPAKT.inhibitor.VIIIEER1.8981e-020.2511image
ENSG00000124243.16,BCAS4KIRPAKT.inhibitor.VIIIEAG1.8981e-020.2511image
chr20:50877554-50882176:+LGGEtoposideEER6.6917e-05-0.2975image
ENSG00000124243.16,BCAS4LGGEtoposideEAG6.6917e-05-0.2975image
ENSG00000124243.16,BCAS4LUADBMS.536924EAG3.6221e-04-0.3216image
chr20:50877554-50882176:+LUADDoxorubicinEER1.5572e-030.2930image
ENSG00000124243.16,BCAS4LUSCAS601245EAG3.6439e-03-0.2504image
chr20:50877554-50882176:+LUSCAS601245EER2.2142e-03-0.2671image
ENSG00000124243.16,BCAS4OVCCT007093EAG1.0529e-040.3175image
chr20:50877554-50882176:+OVAZD8055EER3.9378e-020.1824image
ENSG00000124243.16,BCAS4PAADAKT.inhibitor.VIIIEAG1.8753e-02-0.4576image
chr20:50877554-50882176:+PAADAKT.inhibitor.VIIIEER1.7021e-02-0.4727image
ENSG00000124243.16,BCAS4PCPGCCT007093EAG1.2804e-030.5094image
chr20:50877554-50882176:+PCPGCCT007093EER1.2804e-030.5094image
chr20:50877554-50882176:+PRADAUY922EER1.7761e-02-0.2597image
ENSG00000124243.16,BCAS4PRADAUY922EAG3.9979e-02-0.2246image
ENSG00000124243.16,BCAS4SARCAG.014699EAG1.4164e-020.3633image
chr20:50877554-50882176:+SARCBMS.754807EER9.1387e-030.4284image
ENSG00000124243.16,BCAS4SKCMBIBW2992EAG3.2997e-08-0.6884image
ENSG00000124243.16,BCAS4STADBIBW2992EAG1.0574e-02-0.1985image
ENSG00000124243.16,BCAS4THCACHIR.99021EAG4.2555e-070.2472image
chr20:50877554-50882176:+THCACHIR.99021EER1.8632e-070.2546image
ENSG00000124243.16,BCAS4UCSCHIR.99021EAG4.5670e-03-0.5935image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType