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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: SLC35E3 (ImmuneEditome ID:55508)

1. Gene summary of enriched editing regions for SLC35E3

check button Gene summary
Gene informationGene symbol

SLC35E3

Gene ID

55508

GeneSynonymsBLOV1
GeneCytomap

12q15

GeneTypeprotein-coding
GeneDescriptionsolute carrier family 35 member E3|bladder cancer-overexpressed gene 1 protein|solute carrier family 35, member E2
GeneModificationdate20230428
UniprotIDQ7Z769;A0A669KB59;A0A669KB01;A0A024RB82
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr12:68759413-68760160:+ENST00000319429.6ENSG00000175782.9SLC35E3ncRNA_exonicTigger19b,AluSz6,FLAM_Cchr12:68759413-68760160:+.alignment
chr12:68761250-68762136:+ENST00000538043.1ENSG00000175782.9SLC35E3ncRNA_intronicFRAM,AluJo,MER20,L2achr12:68761250-68762136:+.alignment
chr12:68763434-68768258:+ENST00000398004.3ENSG00000175782.9SLC35E3exonicAluSq2,AluSz,AluSz6,(AT)n,AluJb,AluSp,L1MB2,MIRbchr12:68763434-68768258:+.alignment
chr12:68763434-68768258:+ENST00000431174.2ENSG00000175782.9SLC35E3exonicAluSq2,AluSz,AluSz6,(AT)n,AluJb,AluSp,L1MB2,MIRbchr12:68763434-68768258:+.alignment
chr12:68771131-68771612:+ENST00000538043.1ENSG00000175782.9SLC35E3ncRNA_intronicAluJb,AluSz,L2cchr12:68771131-68771612:+.alignment
chr12:68773457-68776646:+ENST00000538043.1ENSG00000175782.9SLC35E3ncRNA_intronicAluSq2,AluJb,AluJr,MamGypLTR3a,AluSz6,MSTC,FLAM_C,SVA_B,AluSp,AluSx1,(A)nchr12:68773457-68776646:+.alignment
chr12:68777984-68781744:+ENST00000538043.1ENSG00000175782.9SLC35E3ncRNA_intronicL1M4,AluJb,AluJr4,(TTGCC)n,AluSz6,AluJo,AluSp,AluSq,A-richchr12:68777984-68781744:+.alignment
chr12:68784727-68785233:+ENST00000538043.1ENSG00000175782.9SLC35E3ncRNA_intronicAluSx1,AluJb,L2achr12:68784727-68785233:+.alignment
chr12:68791097-68792142:+ENST00000538043.1ENSG00000175782.9SLC35E3ncRNA_intronicAluSq4,(TAA)n,AluJo,AluSx1chr12:68791097-68792142:+.alignment


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2. Tumor-specific enriched editing regions for SLC35E3


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr12:68763434-68768258:+KIRPEER2.3106e-02image
ENSG00000175782.9,SLC35E3KIRPEAG1.9677e-02image
chr12:68763434-68768258:+LIHCEER2.4762e-05image
ENSG00000175782.9,SLC35E3LIHCEAG3.6942e-05image
chr12:68763434-68768258:+LUSCEER2.7566e-02image
ENSG00000175782.9,SLC35E3LUSCEAG3.2439e-02image
ENSG00000175782.9,SLC35E3STADEAG4.4435e-02image
chr12:68763434-68768258:+THCAEER1.2151e-02image
ENSG00000175782.9,SLC35E3THCAEAG1.1889e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000175782.9,SLC35E3SKCMPathEAG3.2791e-022.5632e-02-0.1149image
chr12:68763434-68768258:+SKCMPathEER3.1155e-022.4704e-02-0.1157image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr12:68763434-68768258:+BLCAEER1.5911e-022.7264e-028.4299e-02image
ENSG00000175782.9,SLC35E3BLCAEAG2.2930e-023.4913e-029.8504e-02image
chr12:68763434-68768258:+UVMEER2.0311e-031.1701e-026.4009e-06image
ENSG00000175782.9,SLC35E3UVMEAG2.0311e-031.1572e-026.5126e-06image

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3. Enriched editing regions and immune related genes for SLC35E3


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr12:68763434-68768258:+LIHCEERENSG00000265254,CTD-2350C19.20.19366.2355e-039.6147e-150.4216imageNFUSNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION
chr12:68763434-68768258:+LIHCEERENSG00000250222,CTC-338M12.50.18907.2287e-031.0478e-150.4351imageNFUS;NOP56;TAF15NAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr12:68763434-68768258:+GBMEERENSG00000242814,RP11-436H11.10.32723.4173e-031.4427e-070.4014imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_MYC_TARGETS_V1
chr12:68763434-68768258:+GBMEERENSG00000243746,EEF1A1P100.30457.2387e-035.6293e-080.4132imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_MYC_TARGETS_V1
chr12:68763434-68768258:+GBMEERENSG00000215093,EEF1A1P290.25383.4230e-021.2703e-070.4030imageNNNAGSVA_HALLMARK_MYC_TARGETS_V1
chr12:68763434-68768258:+KICHEERENSG00000205643,CDPF10.52913.9699e-026.3339e-050.4820imageNNOP56;TAF15NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_APOPTOSIS
chr12:68763434-68768258:+UVMEERENSG00000082397,EPB41L3-0.52913.3416e-039.1977e-04-0.4272imageNFUS;NOP56;TAF15NAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr12:68763434-68768258:+UVMEERENSG00000112759,SLC29A1-0.49254.1419e-033.5262e-04-0.4570imageNFUS;NOP56;TAF15NANeutrophilsGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr12:68763434-68768258:+UVMEERENSG00000132819,RBM380.47531.1022e-021.8627e-040.4754imageNFUS;NOP56;TAF15NAGSVA_HALLMARK_ANGIOGENESIS
chr12:68763434-68768258:+UVMEERENSG00000151746,BICD1-0.46791.1659e-023.1463e-04-0.4603imageNFUS;NOP56;TAF15NAT_cells_follicular_helperGSVA_HALLMARK_PROTEIN_SECRETION
chr12:68763434-68768258:+LIHCEERENSG00000265254,CTD-2350C19.20.19366.2355e-039.6147e-150.4216imageNFUSNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION
chr12:68763434-68768258:+LIHCEERENSG00000250222,CTC-338M12.50.18907.2287e-031.0478e-150.4351imageNFUS;NOP56;TAF15NAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr12:68763434-68768258:+GBMEERENSG00000242814,RP11-436H11.10.32723.4173e-031.4427e-070.4014imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_MYC_TARGETS_V1
chr12:68763434-68768258:+GBMEERENSG00000243746,EEF1A1P100.30457.2387e-035.6293e-080.4132imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_MYC_TARGETS_V1
chr12:68763434-68768258:+GBMEERENSG00000215093,EEF1A1P290.25383.4230e-021.2703e-070.4030imageNNNAGSVA_HALLMARK_MYC_TARGETS_V1
chr12:68763434-68768258:+KICHEERENSG00000205643,CDPF10.52913.9699e-026.3339e-050.4820imageNNOP56;TAF15NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_APOPTOSIS
chr12:68763434-68768258:+UVMEERENSG00000082397,EPB41L3-0.52913.3416e-039.1977e-04-0.4272imageNFUS;NOP56;TAF15NAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr12:68763434-68768258:+UVMEERENSG00000112759,SLC29A1-0.49254.1419e-033.5262e-04-0.4570imageNFUS;NOP56;TAF15NANeutrophilsGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr12:68763434-68768258:+UVMEERENSG00000132819,RBM380.47531.1022e-021.8627e-040.4754imageNFUS;NOP56;TAF15NAGSVA_HALLMARK_ANGIOGENESIS
chr12:68763434-68768258:+UVMEERENSG00000151746,BICD1-0.46791.1659e-023.1463e-04-0.4603imageNFUS;NOP56;TAF15NAT_cells_follicular_helperGSVA_HALLMARK_PROTEIN_SECRETION

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4. Enriched editing regions and immune related splicing for SLC35E3


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr12:68763434-68768258:+
KIRCEERESENSG00000197603.9chr537138788:37138848:37139339:37139370:37142309:37142480-0.12733.5349e-027.5401e-21-0.4968imageNFUS;NOP56;TAF15NAT_cells_CD4_naiveGSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr12:68763434-68768258:+
KIRCEERIRENSG00000059804.11chr127924409:7925948:7929683:79298710.17414.5438e-027.8914e-180.4286imageNFUS;NOP56;TAF15NAMonocytesGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASIS
chr12:68763434-68768258:+
LGGEERIRENSG00000110429.9chr1133740938:33742084:33747129:337473200.32594.3296e-105.3382e-220.4084imageNFUS;NOP56;TAF15NAMacrophages_M2GSVA_HALLMARK_UV_RESPONSE_DN
ENSG00000175782.9,SLC35E3
PAADEAGMEXENSG00000172765.12chr3129832773:129832826:129847429:129848412:129857253:129857405:129880308:1298804660.36769.0895e-031.3900e-050.4102imageNACIN1;ADAR;AUH;BCCIP;BUD13;CELF2;CNBP;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM47;RBM5;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YTHDF2;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_BILE_ACID_METABOLISM
ENSG00000175782.9,SLC35E3
PAADEAGESENSG00000172765.12chr3129848345:129848412:129857249:129857405:129880308:129880466-0.36071.1679e-022.0619e-05-0.4026imageNACIN1;ADAR;AUH;BCCIP;BUD13;CELF2;CNBP;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM47;RBM5;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YTHDF2;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_BILE_ACID_METABOLISM
chr12:68763434-68768258:+
PAADEERMEXENSG00000172765.12chr3129832773:129832826:129847429:129848412:129857253:129857405:129880308:1298804660.36451.2349e-021.8186e-050.4069imageNFUS;NOP56;TAF15NAT_cells_CD4_memory_restingGSVA_HALLMARK_BILE_ACID_METABOLISM
chr12:68763434-68768258:+
THYMEERMEXENSG00000099817.7chr191091791:1091907:1092312:1092405:1093755:1093903:1095258:1095336-0.29223.7315e-028.4288e-05-0.4089imageNFUS;NOP56;TAF15NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_NOTCH_SIGNALING
ENSG00000175782.9,SLC35E3
THYMEAGA3ENSG00000177595.13chr11804093:804463:802681:803587:802681:803647-0.34821.1573e-021.7548e-05-0.4170imageNACIN1;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;FAM120A;FBL;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI1;MSI2;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDF1;YWHAG;ZNF184NAMast_cells_restingGSVA_HALLMARK_E2F_TARGETS
ENSG00000175782.9,SLC35E3
THYMEAGIRENSG00000000460.12chr1169849484:169849604:169850264:1698503270.41413.2905e-033.1637e-060.4259imageNACIN1;ADAR;AIFM1;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28B;LSM11;MOV10;MSI1;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM5;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YWHAG;ZNF184NAMast_cells_restingGSVA_HALLMARK_E2F_TARGETS
chr12:68763434-68768258:+
THYMEERIRENSG00000160957.8chr8144511901:144513480:144513570:1445137120.38341.0868e-024.3037e-060.4260imageNFUS;NOP56;TAF15NAT_cells_CD4_naiveGSVA_HALLMARK_MITOTIC_SPINDLE

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5. Enriched editing regions and immune infiltration for SLC35E3


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr12:68763434-68768258:+ACCEERNK_cells_resting4.1583e-020.2344image
chr12:68763434-68768258:+BRCAEERT_cells_regulatory_(Tregs)9.2707e-050.1218image
ENSG00000175782.9,SLC35E3BRCAEAGMast_cells_resting1.9233e-04-0.1162image
chr12:68763434-68768258:+CESCEERT_cells_regulatory_(Tregs)2.8117e-020.1346image
ENSG00000175782.9,SLC35E3CESCEAGT_cells_regulatory_(Tregs)2.7992e-020.1348image
chr12:68763434-68768258:+CHOLEERT_cells_CD4_memory_activated2.8559e-020.3872image
ENSG00000175782.9,SLC35E3CHOLEAGT_cells_CD4_memory_activated2.8609e-020.3871image
ENSG00000175782.9,SLC35E3COADEAGMacrophages_M04.3085e-02-0.1654image
chr12:68763434-68768258:+ESCAEERPlasma_cells2.8674e-020.1736image
ENSG00000175782.9,SLC35E3ESCAEAGT_cells_regulatory_(Tregs)2.3058e-020.1802image
chr12:68763434-68768258:+GBMEERNK_cells_activated1.7413e-020.1878image
ENSG00000175782.9,SLC35E3GBMEAGNK_cells_activated1.6717e-020.1890image
chr12:68763434-68768258:+KICHEERT_cells_CD4_memory_resting6.2665e-03-0.3408image
ENSG00000175782.9,SLC35E3KICHEAGT_cells_CD4_memory_resting6.2472e-03-0.3410image
chr12:68763434-68768258:+KIRCEERB_cells_naive1.2980e-020.1282image
ENSG00000175782.9,SLC35E3KIRCEAGB_cells_naive1.5894e-020.1241image
ENSG00000175782.9,SLC35E3KIRPEAGT_cells_CD4_memory_activated7.4906e-030.1652image
ENSG00000175782.9,SLC35E3LAMLEAGB_cells_naive8.5248e-030.2742image
chr12:68763434-68768258:+LGGEERT_cells_CD4_naive1.7107e-02-0.1053image
ENSG00000175782.9,SLC35E3LGGEAGT_cells_CD4_naive2.0892e-02-0.1020image
chr12:68763434-68768258:+LIHCEERPlasma_cells4.9618e-02-0.1118image
ENSG00000175782.9,SLC35E3LIHCEAGPlasma_cells1.5639e-02-0.1370image
chr12:68763434-68768258:+LUSCEERPlasma_cells3.9918e-020.0955image
ENSG00000175782.9,SLC35E3LUSCEAGPlasma_cells2.7439e-020.1025image
chr12:68763434-68768258:+MESOEERMonocytes3.7369e-02-0.2588image
ENSG00000175782.9,SLC35E3MESOEAGMonocytes3.7369e-02-0.2588image
chr12:68763434-68768258:+OVEERT_cells_CD81.0749e-020.1539image
chr12:68773457-68776646:+OVEERMast_cells_activated2.3443e-020.3491image
ENSG00000175782.9,SLC35E3OVEAGT_cells_CD88.0430e-030.1595image
chr12:68763434-68768258:+PAADEERB_cells_naive4.5182e-030.2485image
ENSG00000175782.9,SLC35E3PAADEAGB_cells_naive3.6376e-030.2533image
chr12:68763434-68768258:+PCPGEERT_cells_CD4_memory_resting4.7939e-020.1699image
ENSG00000175782.9,SLC35E3PCPGEAGT_cells_CD4_memory_resting4.3040e-020.1738image
chr12:68763434-68768258:+PRADEERMacrophages_M25.5412e-030.1266image
ENSG00000175782.9,SLC35E3PRADEAGMacrophages_M24.9706e-030.1281image
chr12:68761250-68762136:+SARCEERT_cells_CD4_memory_resting4.5590e-02-0.3741image
chr12:68763434-68768258:+SARCEERMacrophages_M01.3125e-020.1666image
ENSG00000175782.9,SLC35E3SARCEAGMacrophages_M02.6356e-020.1487image
chr12:68763434-68768258:+SKCMEERT_cells_CD82.4039e-020.1084image
ENSG00000175782.9,SLC35E3SKCMEAGT_cells_CD82.2061e-020.1100image
chr12:68759413-68760160:+STADEERT_cells_CD81.0212e-020.3406image
chr12:68761250-68762136:+STADEERMonocytes3.8168e-020.4087image
chr12:68773457-68776646:+STADEERMonocytes1.6610e-020.4203image
chr12:68763434-68768258:+THCAEERT_cells_CD4_memory_resting1.1480e-02-0.1299image
ENSG00000175782.9,SLC35E3THCAEAGT_cells_CD4_memory_resting1.1255e-02-0.1301image
chr12:68763434-68768258:+THYMEERMacrophages_M15.0042e-040.3279image
ENSG00000175782.9,SLC35E3THYMEAGMacrophages_M13.1980e-040.3354image
chr12:68763434-68768258:+UCECEERDendritic_cells_activated7.0265e-030.2222image
ENSG00000175782.9,SLC35E3UCECEAGDendritic_cells_activated1.0326e-020.2102image
chr12:68763434-68768258:+UCSEERT_cells_follicular_helper1.0616e-02-0.3450image
ENSG00000175782.9,SLC35E3UCSEAGT_cells_follicular_helper1.0165e-02-0.3469image
chr12:68763434-68768258:+UVMEERT_cells_CD4_memory_resting3.6542e-020.2776image
ENSG00000175782.9,SLC35E3UVMEAGT_cells_CD4_memory_resting3.6381e-020.2778image


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6. Enriched editing regions and immune gene sets for SLC35E3


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000175782.9,SLC35E3KIRCEAG4.6981e-03-0.14532.6995e-02-0.11392.9249e-02-0.11233.0252e-02-0.1116image
chr12:68763434-68768258:+KIRCEER3.6793e-03-0.14962.6441e-02-0.11464.5304e-02-0.10344.8395e-02-0.1020image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr12:68763434-68768258:+ACCGSVA_HALLMARK_PEROXISOMEEER9.2204e-04-0.3725image
ENSG00000175782.9,SLC35E3ACCGSVA_HALLMARK_ADIPOGENESISEAG5.8949e-04-0.3852image
chr12:68763434-68768258:+BLCAGSVA_HALLMARK_COAGULATIONEER6.0727e-030.1474image
ENSG00000175782.9,SLC35E3BLCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG4.3120e-030.1529image
chr12:68759413-68760160:+BRCAGSVA_HALLMARK_MITOTIC_SPINDLEEER3.0754e-02-0.2864image
ENSG00000175782.9,SLC35E3BRCAGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.8108e-06-0.1484image
chr12:68763434-68768258:+BRCAGSVA_HALLMARK_PROTEIN_SECRETIONEER4.9237e-06-0.1422image
chr12:68763434-68768258:+CESCGSVA_HALLMARK_E2F_TARGETSEER2.4504e-02-0.1379image
ENSG00000175782.9,SLC35E3CESCGSVA_HALLMARK_E2F_TARGETSEAG2.4122e-02-0.1383image
ENSG00000175782.9,SLC35E3COADGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.2521e-02-0.2035image
chr12:68763434-68768258:+COADGSVA_HALLMARK_MITOTIC_SPINDLEEER2.0000e-02-0.1898image
ENSG00000175782.9,SLC35E3ESCAGSVA_HALLMARK_SPERMATOGENESISEAG6.9301e-03-0.2134image
chr12:68763434-68768258:+ESCAGSVA_HALLMARK_SPERMATOGENESISEER6.2781e-03-0.2159image
chr12:68759413-68760160:+ESCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER6.5131e-030.4042image
chr12:68763434-68768258:+GBMGSVA_HALLMARK_UV_RESPONSE_UPEER3.1678e-030.2319image
ENSG00000175782.9,SLC35E3GBMGSVA_HALLMARK_UV_RESPONSE_UPEAG3.2280e-030.2315image
ENSG00000175782.9,SLC35E3HNSCGSVA_HALLMARK_GLYCOLYSISEAG4.6158e-03-0.1415image
chr12:68763434-68768258:+HNSCGSVA_HALLMARK_GLYCOLYSISEER4.5468e-03-0.1418image
ENSG00000175782.9,SLC35E3KICHGSVA_HALLMARK_HEME_METABOLISMEAG1.0475e-04-0.4692image
chr12:68763434-68768258:+KICHGSVA_HALLMARK_HEME_METABOLISMEER1.0455e-04-0.4693image
chr12:68763434-68768258:+KIRCGSVA_HALLMARK_MTORC1_SIGNALINGEER1.2701e-03-0.1658image
ENSG00000175782.9,SLC35E3KIRCGSVA_HALLMARK_MTORC1_SIGNALINGEAG1.4721e-03-0.1632image
ENSG00000175782.9,SLC35E3KIRPGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.5219e-02-0.1501image
chr12:68763434-68768258:+KIRPGSVA_HALLMARK_MITOTIC_SPINDLEEER1.2884e-02-0.1541image
chr12:68763434-68768258:+LAMLGSVA_HALLMARK_BILE_ACID_METABOLISMEER2.2299e-020.2672image
ENSG00000175782.9,SLC35E3LAMLGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG4.9795e-02-0.2063image
chr12:68763434-68768258:+LGGGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER6.7576e-06-0.1975image
ENSG00000175782.9,SLC35E3LGGGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG3.1531e-05-0.1827image
ENSG00000175782.9,SLC35E3LIHCGSVA_HALLMARK_G2M_CHECKPOINTEAG4.6414e-04-0.1973image
chr12:68763434-68768258:+LIHCGSVA_HALLMARK_G2M_CHECKPOINTEER4.0868e-04-0.1998image
chr12:68763434-68768258:+LUADGSVA_HALLMARK_MYC_TARGETS_V1EER2.7064e-04-0.1775image
ENSG00000175782.9,SLC35E3LUADGSVA_HALLMARK_MYC_TARGETS_V1EAG1.2765e-04-0.1863image
chr12:68763434-68768258:+LUSCGSVA_HALLMARK_SPERMATOGENESISEER2.9083e-03-0.1381image
ENSG00000175782.9,SLC35E3LUSCGSVA_HALLMARK_SPERMATOGENESISEAG9.7216e-04-0.1528image
ENSG00000175782.9,SLC35E3OVGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.0152e-040.2322image
chr12:68763434-68768258:+OVGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER5.9532e-050.2401image
chr12:68773457-68776646:+OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.9017e-020.3605image
ENSG00000175782.9,SLC35E3PAADGSVA_HALLMARK_PROTEIN_SECRETIONEAG4.3080e-03-0.2488image
chr12:68763434-68768258:+PAADGSVA_HALLMARK_PROTEIN_SECRETIONEER5.4358e-03-0.2434image
chr12:68763434-68768258:+PCPGGSVA_HALLMARK_PEROXISOMEEER2.8426e-02-0.1880image
ENSG00000175782.9,SLC35E3PCPGGSVA_HALLMARK_PEROXISOMEEAG2.3585e-02-0.1941image
ENSG00000175782.9,SLC35E3PRADGSVA_HALLMARK_PROTEIN_SECRETIONEAG3.5687e-07-0.2301image
chr12:68763434-68768258:+PRADGSVA_HALLMARK_PROTEIN_SECRETIONEER3.5722e-07-0.2301image
chr12:68763434-68768258:+SARCGSVA_HALLMARK_MYC_TARGETS_V1EER1.5456e-030.2118image
ENSG00000175782.9,SLC35E3SARCGSVA_HALLMARK_MYC_TARGETS_V1EAG8.3559e-040.2222image
chr12:68773457-68776646:+SARCGSVA_HALLMARK_MYOGENESISEER2.8865e-02-0.4768image
chr12:68763434-68768258:+SKCMGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER2.0932e-040.1773image
ENSG00000175782.9,SLC35E3SKCMGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG2.3025e-040.1761image
ENSG00000175782.9,SLC35E3STADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.2063e-030.1767image
chr12:68761250-68762136:+STADGSVA_HALLMARK_P53_PATHWAYEER2.6271e-02-0.4352image
chr12:68763434-68768258:+STADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.2816e-030.1760image
chr12:68773457-68776646:+STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.7417e-02-0.3898image
chr12:68759413-68760160:+STADGSVA_HALLMARK_SPERMATOGENESISEER6.4012e-03-0.3601image
ENSG00000175782.9,SLC35E3TGCTGSVA_HALLMARK_APOPTOSISEAG7.8856e-050.3198image
chr12:68763434-68768258:+TGCTGSVA_HALLMARK_APOPTOSISEER7.1172e-050.3216image
ENSG00000175782.9,SLC35E3THCAGSVA_HALLMARK_PROTEIN_SECRETIONEAG3.1658e-03-0.1512image
chr12:68763434-68768258:+THCAGSVA_HALLMARK_PROTEIN_SECRETIONEER3.3653e-03-0.1505image
chr12:68763434-68768258:+THYMGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER3.6951e-06-0.4268image
ENSG00000175782.9,SLC35E3THYMGSVA_HALLMARK_G2M_CHECKPOINTEAG3.8032e-05-0.3805image
chr12:68763434-68768258:+UCECGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER2.8104e-020.1818image
ENSG00000175782.9,SLC35E3UCECGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG2.5243e-020.1839image
chr12:68763434-68768258:+UVMGSVA_HALLMARK_MITOTIC_SPINDLEEER2.4806e-03-0.3932image
ENSG00000175782.9,SLC35E3UVMGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.4802e-03-0.3932image


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7. Enriched editing regions and drugs for SLC35E3


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr12:68763434-68768258:+ACCLenalidomideEER9.3722e-04-0.3720image
ENSG00000175782.9,SLC35E3ACCLenalidomideEAG8.0423e-04-0.3764image
chr12:68763434-68768258:+BLCAAZD7762EER3.6822e-06-0.2462image
ENSG00000175782.9,SLC35E3BLCAAZD7762EAG5.0009e-06-0.2423image
ENSG00000175782.9,SLC35E3BRCAAZD.2281EAG3.6705e-10-0.1941image
chr12:68763434-68768258:+BRCAAZD.2281EER2.2689e-09-0.1855image
chr12:68759413-68760160:+BRCAElesclomolEER6.7093e-04-0.4373image
chr12:68763434-68768258:+CESCBAY.61.3606EER3.5488e-020.1290image
ENSG00000175782.9,SLC35E3CESCBAY.61.3606EAG3.5600e-020.1289image
chr12:68763434-68768258:+CHOLGNF.2EER4.5837e-030.4882image
ENSG00000175782.9,SLC35E3CHOLGNF.2EAG3.8237e-030.4968image
chr12:68763434-68768258:+COADGDC.0449EER4.6649e-02-0.1627image
chr12:68773457-68776646:+ESCAMidostaurinEER3.1672e-02-0.4813image
chr12:68759413-68760160:+ESCAAKT.inhibitor.VIIIEER1.5737e-030.4625image
ENSG00000175782.9,SLC35E3ESCADoxorubicinEAG8.1590e-030.2091image
chr12:68763434-68768258:+ESCADoxorubicinEER8.1653e-030.2091image
ENSG00000175782.9,SLC35E3GBMKU.55933EAG3.1358e-02-0.1703image
chr12:68763434-68768258:+GBMKU.55933EER2.7554e-02-0.1742image
ENSG00000175782.9,SLC35E3HNSCGDC0941EAG1.0796e-06-0.2413image
chr12:68763434-68768258:+HNSCGDC0941EER1.1017e-06-0.2411image
ENSG00000175782.9,SLC35E3KICHAMG.706EAG9.9054e-04-0.4051image
chr12:68763434-68768258:+KICHAMG.706EER9.9008e-04-0.4051image
chr12:68763434-68768258:+KIRCErlotinibEER4.4530e-040.1807image
ENSG00000175782.9,SLC35E3KIRCErlotinibEAG2.9622e-040.1856image
ENSG00000175782.9,SLC35E3KIRPKU.55933EAG3.1105e-02-0.1335image
chr12:68763434-68768258:+KIRPGDC.0449EER2.4938e-02-0.1391image
chr12:68763434-68768258:+LAMLBX.795EER2.2722e-020.2664image
chr12:68763434-68768258:+LGGKU.55933EER9.4985e-08-0.2334image
ENSG00000175782.9,SLC35E3LGGBMS.708163EAG8.5769e-070.2153image
ENSG00000175782.9,SLC35E3LIHCBAY.61.3606EAG8.2383e-040.1887image
chr12:68763434-68768258:+LIHCBAY.61.3606EER4.1883e-040.1995image
chr12:68763434-68768258:+LUADLFM.A13EER8.3235e-05-0.1915image
ENSG00000175782.9,SLC35E3LUADLFM.A13EAG6.2903e-05-0.1944image
chr12:68763434-68768258:+LUSCLenalidomideEER1.5191e-03-0.1470image
ENSG00000175782.9,SLC35E3LUSCCGP.60474EAG1.1394e-03-0.1508image
ENSG00000175782.9,SLC35E3MESOGW.441756EAG1.7286e-020.2944image
chr12:68763434-68768258:+MESOGW.441756EER1.7286e-020.2944image
chr12:68773457-68776646:+OVAZD6244EER7.7768e-03-0.4052image
ENSG00000175782.9,SLC35E3OVMG.132EAG7.8116e-06-0.2664image
chr12:68763434-68768258:+OVMG.132EER5.5673e-06-0.2710image
chr12:68763434-68768258:+PAADBMS.509744EER8.4138e-03-0.2311image
ENSG00000175782.9,SLC35E3PAADBMS.509744EAG1.0004e-02-0.2252image
chr12:68763434-68768258:+PCPGAxitinibEER1.8751e-02-0.2013image
ENSG00000175782.9,SLC35E3PCPGAxitinibEAG1.5785e-02-0.2066image
ENSG00000175782.9,SLC35E3PRADAZD6482EAG3.7888e-060.2096image
chr12:68763434-68768258:+PRADAZD6482EER3.9165e-060.2093image
chr12:68763434-68768258:+READBicalutamideEER2.3883e-020.3016image
ENSG00000175782.9,SLC35E3READBicalutamideEAG2.3883e-020.3016image
chr12:68773457-68776646:+SARCBMS.754807EER2.0157e-020.5028image
chr12:68761250-68762136:+SARCFH535EER2.0740e-020.4274image
ENSG00000175782.9,SLC35E3SARCBI.D1870EAG1.7066e-04-0.2491image
chr12:68763434-68768258:+SARCDMOGEER9.8625e-050.2589image
chr12:68763434-68768258:+SKCMGDC.0449EER9.0165e-06-0.2115image
ENSG00000175782.9,SLC35E3SKCMGDC.0449EAG9.5512e-06-0.2110image
chr12:68763434-68768258:+STADAZ628EER8.2588e-05-0.2144image
chr12:68761250-68762136:+STADEHT.1864EER2.1567e-03-0.5742image
chr12:68759413-68760160:+STADCI.1040EER9.5155e-03-0.3436image
ENSG00000175782.9,SLC35E3STADAZ628EAG1.9682e-04-0.2027image
chr12:68773457-68776646:+STADGSK269962AEER5.8501e-03-0.4764image
ENSG00000175782.9,SLC35E3TGCTAZ628EAG1.9038e-04-0.3031image
chr12:68763434-68768258:+TGCTAZ628EER1.4496e-04-0.3083image
chr12:68763434-68768258:+THCABortezomibEER3.9974e-05-0.2096image
ENSG00000175782.9,SLC35E3THCABortezomibEAG4.0027e-05-0.2093image
chr12:68763434-68768258:+THYMCGP.082996EER2.0022e-060.4372image
ENSG00000175782.9,SLC35E3THYMCGP.082996EAG5.7472e-070.4536image
ENSG00000175782.9,SLC35E3UCECA.770041EAG1.1207e-03-0.2653image
chr12:68763434-68768258:+UCECA.770041EER3.5037e-04-0.2919image
chr12:68763434-68768258:+UCSGefitinibEER2.5586e-03-0.4024image
ENSG00000175782.9,SLC35E3UCSGefitinibEAG2.9897e-03-0.3966image
chr12:68763434-68768258:+UVMBMS.536924EER8.3265e-04-0.4304image
ENSG00000175782.9,SLC35E3UVMBMS.536924EAG8.2544e-04-0.4307image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType