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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ACER3 (ImmuneEditome ID:55331)

1. Gene summary of enriched editing regions for ACER3

check button Gene summary
Gene informationGene symbol

ACER3

Gene ID

55331

GeneSynonymsAPHC|PHCA|PLDECO
GeneCytomap

11q13.5

GeneTypeprotein-coding
GeneDescriptionalkaline ceramidase 3|alkCDase 3|alkaline CDase 3|alkaline dihydroceramidase SB89|alkaline phytoceramidase|phytoceramidase, alkaline
GeneModificationdate20230517
UniprotIDQ9NUN7;E9PL35;E9PR08;E9PLZ9;A0A7P0Z4N4;B7Z2Q2;E9PKR3;B7Z2V2;J3KN85;A0A7P0T836;A0A7P0TAT0;A0A7P0TAD8;A0A7P0T842;E9PIN9;A0A7P0T912;A0A7P0T8K3
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr11:76992065-76993150:+ENST00000527508.1ENSG00000078124.10ACER3ncRNA_intronicAluJr,AluJb,L2b,MIRbchr11:76992065-76993150:+.alignment
chr11:76992065-76993150:+ENST00000530182.4ENSG00000078124.10ACER3ncRNA_intronicAluJr,AluJb,L2b,MIRbchr11:76992065-76993150:+.alignment
chr11:77012782-77013658:+ENST00000525325.1ENSG00000078124.10ACER3ncRNA_intronicL1ME1chr11:77012782-77013658:+.alignment
chr11:77012782-77013658:+ENST00000527508.1ENSG00000078124.10ACER3ncRNA_intronicL1ME1chr11:77012782-77013658:+.alignment
chr11:77022835-77024102:+ENST00000278544.8ENSG00000078124.10ACER3UTR3A-rich,AluY,Aluchr11:77022835-77024102:+.alignment
chr11:77022835-77024102:+ENST00000532485.4ENSG00000078124.10ACER3UTR3A-rich,AluY,Aluchr11:77022835-77024102:+.alignment
chr11:77025428-77025717:+ENST00000532485.4ENSG00000078124.10ACER3UTR3MER58C,AluSzchr11:77025428-77025717:+.alignment


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2. Tumor-specific enriched editing regions for ACER3


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr11:77022835-77024102:+BRCAEER1.0154e-02image
ENSG00000078124.10,ACER3BRCAEAG1.4834e-04image
ENSG00000078124.10,ACER3COADEAG3.1286e-04image
chr11:77022835-77024102:+HNSCEER8.8109e-05image
ENSG00000078124.10,ACER3HNSCEAG1.4550e-06image
ENSG00000078124.10,ACER3THCAEAG1.1426e-02image
ENSG00000078124.10,ACER3UCECEAG1.2395e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000078124.10,ACER3LIHCPathEAG5.6803e-037.6399e-04-0.3957image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for ACER3


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr11:77022835-77024102:+GBMEERENSG00000186187,ZNRF1-0.42563.7855e-051.3336e-07-0.4024imageNNNAMacrophages_M0GSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr11:77022835-77024102:+GBMEERENSG00000144559,TAMM41-0.41465.7810e-053.3657e-08-0.4195imageNNNAMonocytesGSVA_HALLMARK_XENOBIOTIC_METABOLISM
chr11:77022835-77024102:+GBMEERENSG00000223722,RP11-467L13.50.40461.0875e-043.5950e-090.4454imageNNNAMacrophages_M1GSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr11:77022835-77024102:+GBMEERENSG00000067365,METTL22-0.39721.5176e-041.3773e-07-0.4019imageNNNAMonocytesGSVA_HALLMARK_BILE_ACID_METABOLISM
chr11:77022835-77024102:+GBMEERENSG00000136891,TEX10-0.37643.8386e-043.5146e-08-0.4190imageNNNAMonocytesGSVA_HALLMARK_XENOBIOTIC_METABOLISM
chr11:77022835-77024102:+GBMEERENSG00000186187,ZNRF1-0.42563.7855e-051.3336e-07-0.4024imageNNNAMacrophages_M0GSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr11:77022835-77024102:+GBMEERENSG00000144559,TAMM41-0.41465.7810e-053.3657e-08-0.4195imageNNNAMonocytesGSVA_HALLMARK_XENOBIOTIC_METABOLISM
chr11:77022835-77024102:+GBMEERENSG00000223722,RP11-467L13.50.40461.0875e-043.5950e-090.4454imageNNNAMacrophages_M1GSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr11:77022835-77024102:+GBMEERENSG00000067365,METTL22-0.39721.5176e-041.3773e-07-0.4019imageNNNAMonocytesGSVA_HALLMARK_BILE_ACID_METABOLISM
chr11:77022835-77024102:+GBMEERENSG00000136891,TEX10-0.37643.8386e-043.5146e-08-0.4190imageNNNAMonocytesGSVA_HALLMARK_XENOBIOTIC_METABOLISM

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4. Enriched editing regions and immune related splicing for ACER3


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000078124.10,ACER3
ESCAEAGIRENSG00000131143.4chr1685804936:85805864:85806455:85806805-0.33431.3865e-022.1915e-07-0.4092imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM27;RNF219;RTCB;SLBP;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDF1;ZC3H7BNAB_cells_naiveGSVA_HALLMARK_MTORC1_SIGNALING
ENSG00000078124.10,ACER3
ESCAEAGIRENSG00000016864.12chr352694488:52695587:52695927:52696040-0.41926.6485e-042.0612e-08-0.4241imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM27;RBM47;RNF219;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDF1NAMacrophages_M2GSVA_HALLMARK_APICAL_JUNCTION
ENSG00000078124.10,ACER3
ESCAEAGIRENSG00000163635.13chr363995504:63996483:63999449:63999554-0.38632.3792e-039.3132e-08-0.4129imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM27;RBM47;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDF1;ZC3H7BNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MTORC1_SIGNALING
ENSG00000078124.10,ACER3
ESCAEAGIRENSG00000135469.9chr1256267681:56267940:56269058:56269108-0.26994.7703e-028.4778e-06-0.4003imageNAUH;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;NOP56;NUMA1;PCBP2;PRPF8;PTBP1;RBFOX2;RBM10;SLBP;SND1;SRSF1;SRSF10;SRSF3;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDF1NAMacrophages_M2GSVA_HALLMARK_GLYCOLYSIS
chr11:77022835-77024102:+
ESCAEERIRENSG00000080823.17chr14102232534:102232708:102233687:102233789-0.36803.1041e-031.9499e-07-0.4200imageNNNAB_cells_naiveGSVA_HALLMARK_GLYCOLYSIS
ENSG00000078124.10,ACER3
ESCAEAGIRENSG00000125901.5chr203046613:3046900:3047734:3048254-0.28942.7042e-024.1751e-06-0.4046imageNAIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;LARP4B;LIN28;LIN28A;LIN28B;MOV10;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RNF219;RTCB;SLTM;SND1;SRSF1;SRSF10;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDF1;ZC3H7BNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
ENSG00000078124.10,ACER3
ESCAEAGIRENSG00000100325.10chr2229832244:29833614:29834488:29834550-0.32512.7138e-021.7589e-07-0.4047imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RNF219;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDF1NAMacrophages_M0GSVA_HALLMARK_MTORC1_SIGNALING
ENSG00000078124.10,ACER3
ESCAEAGIRENSG00000113240.8chr5178616877:178616948:178617343:178617434-0.34111.4307e-021.7933e-07-0.4045imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LIN28;LIN28B;LSM11;MBNL2;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RBM47;RNF219;SLTM;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;ZC3H7BNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
ENSG00000078124.10,ACER3
ESCAEAGIRENSG00000166801.11chr1159142844:59143695:59145826:59145856-0.29371.8407e-022.0758e-06-0.4083imageNADAR;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;PCBP2;PRPF8;PTBP1;RBFOX2;RBM10;RBM27;RBM47;RTCB;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF9;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2NADendritic_cells_activatedGSVA_HALLMARK_PROTEIN_SECRETION
ENSG00000078124.10,ACER3
ESCAEAGIRENSG00000165792.13chr1420996526:20996711:20996784:20997005-0.41747.8655e-044.5295e-08-0.4147imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LIN28;LIN28B;LSM11;MOV10;MSI2;NCBP3;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM27;RNF219;SLBP;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;ZC3H7BNAB_cells_naiveGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSE

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5. Enriched editing regions and immune infiltration for ACER3


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000078124.10,ACER3BLCAEAGT_cells_regulatory_(Tregs)4.1333e-03-0.1727image
chr11:77022835-77024102:+BRCAEERT_cells_gamma_delta4.2904e-020.0762image
ENSG00000078124.10,ACER3BRCAEAGMacrophages_M28.2455e-03-0.0890image
ENSG00000078124.10,ACER3CESCEAGB_cells_naive2.3632e-02-0.1522image
chr11:77025428-77025717:+DLBCEERB_cells_memory4.6368e-03-0.5108image
ENSG00000078124.10,ACER3DLBCEAGB_cells_memory2.7910e-02-0.3665image
chr11:77012782-77013658:+ESCAEERDendritic_cells_resting1.5758e-02-0.3891image
chr11:77022835-77024102:+ESCAEERT_cells_regulatory_(Tregs)2.4125e-04-0.2855image
ENSG00000078124.10,ACER3ESCAEAGT_cells_regulatory_(Tregs)2.8637e-05-0.3234image
chr11:77022835-77024102:+GBMEERMacrophages_M11.6368e-030.2470image
ENSG00000078124.10,ACER3GBMEAGMacrophages_M08.0879e-04-0.2583image
chr11:77022835-77024102:+HNSCEERT_cells_follicular_helper3.2589e-02-0.1139image
ENSG00000078124.10,ACER3HNSCEAGMacrophages_M12.0781e-020.1153image
ENSG00000078124.10,ACER3KICHEAGT_cells_gamma_delta3.4561e-020.3194image
ENSG00000078124.10,ACER3KIRCEAGEosinophils2.1928e-02-0.1213image
ENSG00000078124.10,ACER3LAMLEAGB_cells_naive7.2046e-040.3021image
ENSG00000078124.10,ACER3LGGEAGMacrophages_M11.1365e-030.1416image
ENSG00000078124.10,ACER3LIHCEAGMacrophages_M16.3261e-030.3168image
ENSG00000078124.10,ACER3LUADEAGMast_cells_resting3.5347e-020.1108image
chr11:77022835-77024102:+LUSCEERMacrophages_M12.1999e-020.1307image
ENSG00000078124.10,ACER3LUSCEAGT_cells_CD81.3119e-020.1278image
ENSG00000078124.10,ACER3MESOEAGMonocytes2.2535e-02-0.2764image
ENSG00000078124.10,ACER3PAADEAGNK_cells_activated1.6856e-02-0.1930image
ENSG00000078124.10,ACER3PCPGEAGB_cells_naive7.8433e-030.2045image
ENSG00000078124.10,ACER3PRADEAGB_cells_memory4.8054e-02-0.0939image
chr11:77025428-77025717:+READEERNeutrophils2.0893e-020.3054image
ENSG00000078124.10,ACER3SARCEAGT_cells_CD4_naive3.3293e-02-0.1484image
ENSG00000078124.10,ACER3SKCMEAGT_cells_CD89.2020e-060.2176image
chr11:76992065-76993150:+STADEERT_cells_CD4_memory_activated2.1186e-020.4335image
chr11:77022835-77024102:+STADEERNeutrophils6.6500e-03-0.1476image
ENSG00000078124.10,ACER3STADEAGEosinophils5.9734e-03-0.1463image
ENSG00000078124.10,ACER3TGCTEAGT_cells_CD4_memory_activated1.1467e-020.3548image
ENSG00000078124.10,ACER3UCECEAGMonocytes5.9518e-030.2680image
ENSG00000078124.10,ACER3UCSEAGT_cells_gamma_delta2.7606e-030.4406image


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6. Enriched editing regions and immune gene sets for ACER3


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000078124.10,ACER3BLCAGSVA_HALLMARK_UV_RESPONSE_UPEAG4.3299e-060.2735image
chr11:77022835-77024102:+BRCAGSVA_HALLMARK_APOPTOSISEER1.2928e-040.1435image
ENSG00000078124.10,ACER3BRCAGSVA_HALLMARK_APOPTOSISEAG8.4982e-030.0887image
ENSG00000078124.10,ACER3CESCGSVA_HALLMARK_APOPTOSISEAG8.5763e-030.1764image
chr11:77022835-77024102:+COADGSVA_HALLMARK_E2F_TARGETSEER2.8760e-020.2387image
ENSG00000078124.10,ACER3COADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG4.3768e-02-0.1435image
ENSG00000078124.10,ACER3DLBCGSVA_HALLMARK_PROTEIN_SECRETIONEAG7.4632e-030.4385image
chr11:77025428-77025717:+DLBCGSVA_HALLMARK_PROTEIN_SECRETIONEER2.3835e-040.6316image
ENSG00000078124.10,ACER3ESCAGSVA_HALLMARK_GLYCOLYSISEAG7.1550e-050.3077image
chr11:77012782-77013658:+ESCAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER7.7709e-050.5964image
chr11:77022835-77024102:+ESCAGSVA_HALLMARK_HYPOXIAEER1.3062e-040.2970image
ENSG00000078124.10,ACER3GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.6949e-070.3835image
chr11:77022835-77024102:+GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.2238e-050.3382image
ENSG00000078124.10,ACER3HNSCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG7.4141e-030.1334image
ENSG00000078124.10,ACER3KICHGSVA_HALLMARK_PEROXISOMEEAG2.5659e-02-0.3362image
ENSG00000078124.10,ACER3KIRCGSVA_HALLMARK_HYPOXIAEAG3.6307e-040.1877image
ENSG00000078124.10,ACER3KIRPGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.3883e-030.2083image
ENSG00000078124.10,ACER3LAMLGSVA_HALLMARK_COMPLEMENTEAG2.3324e-02-0.2053image
ENSG00000078124.10,ACER3LGGGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG2.7850e-100.2709image
ENSG00000078124.10,ACER3LIHCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG3.0320e-04-0.4111image
ENSG00000078124.10,ACER3LUADGSVA_HALLMARK_DNA_REPAIREAG9.7226e-030.1359image
chr11:77022835-77024102:+LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER7.2643e-050.2244image
ENSG00000078124.10,ACER3LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.0613e-040.1986image
ENSG00000078124.10,ACER3OVGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.7348e-020.1442image
chr11:77022835-77024102:+OVGSVA_HALLMARK_BILE_ACID_METABOLISMEER3.9474e-030.1765image
ENSG00000078124.10,ACER3PAADGSVA_HALLMARK_ANGIOGENESISEAG3.9151e-030.2320image
ENSG00000078124.10,ACER3PCPGGSVA_HALLMARK_DNA_REPAIREAG1.7973e-02-0.1824image
ENSG00000078124.10,ACER3PRADGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG2.4458e-060.2215image
ENSG00000078124.10,ACER3SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.4862e-020.1695image
ENSG00000078124.10,ACER3SKCMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG3.3164e-050.2040image
chr11:76992065-76993150:+STADGSVA_HALLMARK_DNA_REPAIREER9.0089e-030.4843image
chr11:77022835-77024102:+STADGSVA_HALLMARK_KRAS_SIGNALING_DNEER8.2907e-040.1813image
ENSG00000078124.10,ACER3STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG8.4856e-060.2348image
ENSG00000078124.10,ACER3TGCTGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG1.6882e-02-0.3365image
ENSG00000078124.10,ACER3THCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG4.3826e-020.1056image
ENSG00000078124.10,ACER3THYMGSVA_HALLMARK_APOPTOSISEAG4.5817e-020.2160image
ENSG00000078124.10,ACER3UVMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG4.1856e-030.3382image


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7. Enriched editing regions and drugs for ACER3


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000078124.10,ACER3ACCJNK.Inhibitor.VIIIEAG1.6890e-02-0.4558image
ENSG00000078124.10,ACER3BLCACGP.60474EAG1.9741e-05-0.2547image
chr11:77022835-77024102:+BRCAAZD6244EER8.1782e-04-0.1256image
ENSG00000078124.10,ACER3BRCAAG.014699EAG6.1415e-03-0.0923image
ENSG00000078124.10,ACER3CESCAS601245EAG1.2184e-02-0.1684image
ENSG00000078124.10,ACER3COADAG.014699EAG1.1077e-02-0.1802image
chr11:77022835-77024102:+COADCytarabineEER8.9776e-04-0.3557image
chr11:77025428-77025717:+DLBCATRAEER4.3106e-04-0.6110image
ENSG00000078124.10,ACER3DLBCEmbelinEAG3.3834e-03-0.4754image
chr11:77022835-77024102:+ESCAEHT.1864EER1.7347e-040.2917image
ENSG00000078124.10,ACER3ESCAEHT.1864EAG1.6661e-040.2925image
chr11:77012782-77013658:+ESCALFM.A13EER1.6341e-020.3871image
ENSG00000078124.10,ACER3GBMBIBW2992EAG4.3305e-05-0.3127image
chr11:77022835-77024102:+GBMIPA.3EER1.2847e-050.3374image
chr11:77022835-77024102:+HNSCCytarabineEER2.8613e-030.1585image
ENSG00000078124.10,ACER3HNSCJNK.9LEAG6.8971e-03-0.1346image
ENSG00000078124.10,ACER3KICHBMS.536924EAG4.6953e-02-0.3012image
ENSG00000078124.10,ACER3KIRPCisplatinEAG6.6073e-03-0.1775image
ENSG00000078124.10,ACER3LAMLCytarabineEAG1.1242e-03-0.2915image
ENSG00000078124.10,ACER3LGGIPA.3EAG5.8681e-150.3318image
ENSG00000078124.10,ACER3LIHCAKT.inhibitor.VIIIEAG1.2061e-03-0.3767image
ENSG00000078124.10,ACER3LUADBMS.509744EAG6.2979e-04-0.1791image
ENSG00000078124.10,ACER3LUSCGefitinibEAG8.5228e-04-0.1715image
chr11:77022835-77024102:+LUSCKU.55933EER2.5065e-03-0.1719image
ENSG00000078124.10,ACER3MESOCGP.082996EAG2.7149e-02-0.2680image
ENSG00000078124.10,ACER3OVAZ628EAG8.6917e-04-0.2008image
chr11:77022835-77024102:+OVCGP.082996EER1.5879e-040.2300image
ENSG00000078124.10,ACER3PAADElesclomolEAG3.5451e-02-0.1702image
ENSG00000078124.10,ACER3PCPGBicalutamideEAG2.0181e-03-0.2366image
ENSG00000078124.10,ACER3PRADCytarabineEAG6.8100e-040.1606image
ENSG00000078124.10,ACER3SARCKU.55933EAG1.6096e-02-0.1675image
ENSG00000078124.10,ACER3SKCMAG.014699EAG1.7345e-050.2112image
chr11:77022835-77024102:+STADGW843682XEER3.2467e-04-0.1947image
chr11:76992065-76993150:+STADCamptothecinEER3.5625e-03-0.5321image
ENSG00000078124.10,ACER3STADBMS.509744EAG1.3998e-04-0.2016image
chr11:77025428-77025717:+TGCTGefitinibEER3.3241e-03-0.4642image
ENSG00000078124.10,ACER3TGCTGefitinibEAG1.1779e-03-0.4458image
ENSG00000078124.10,ACER3THCABMS.708163EAG1.7338e-02-0.1245image
ENSG00000078124.10,ACER3UCECCytarabineEAG8.3102e-030.2575image
ENSG00000078124.10,ACER3UCSDoxorubicinEAG2.7897e-02-0.3316image
ENSG00000078124.10,ACER3UVMJW.7.52.1EAG5.3488e-04-0.4034image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType