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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: DDX19A (ImmuneEditome ID:55308)

1. Gene summary of enriched editing regions for DDX19A

check button Gene summary
Gene informationGene symbol

DDX19A

Gene ID

55308

GeneSynonymsDDX19-DDX19L|DDX19L
GeneCytomap

16q22.1

GeneTypeprotein-coding
GeneDescriptionATP-dependent RNA helicase DDX19A|DDX19-like protein|DEAD (Asp-Glu-Ala-As) box polypeptide 19A|DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A|DEAD box protein 19A|RNA helicase
GeneModificationdate20230329
UniprotIDQ9NUU7;I3L0H8;H3BP50;H3BP36;H3BTB3;H3BSL8;J3QRH0
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr16:70359574-70360074:+ENST00000562509.4ENSG00000168872.14DDX19AncRNA_intronicAluSx,(T)n,AluJbchr16:70359574-70360074:+.alignment
chr16:70359574-70360074:+ENST00000567012.4ENSG00000168872.14DDX19AncRNA_intronicAluSx,(T)n,AluJbchr16:70359574-70360074:+.alignment
chr16:70359574-70360074:+ENST00000569244.5ENSG00000168872.14DDX19AncRNA_intronicAluSx,(T)n,AluJbchr16:70359574-70360074:+.alignment
chr16:70361826-70362321:+ENST00000567012.4ENSG00000168872.14DDX19AncRNA_intronicAluSxchr16:70361826-70362321:+.alignment


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2. Tumor-specific enriched editing regions for DDX19A


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
ENSG00000168872.14,DDX19AKIRCEAG1.8464e-02image
ENSG00000168872.14,DDX19ASTADEAG1.9372e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for DDX19A


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for DDX19A


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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5. Enriched editing regions and immune infiltration for DDX19A


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000168872.14,DDX19AACCEAGB_cells_memory1.6141e-020.4428image
ENSG00000168872.14,DDX19ABLCAEAGT_cells_CD4_naive2.6400e-020.2514image
ENSG00000168872.14,DDX19ABRCAEAGNK_cells_activated2.5000e-020.0919image
ENSG00000168872.14,DDX19ACOADEAGDendritic_cells_activated6.2578e-090.7765image
chr16:70361826-70362321:+ESCAEERNK_cells_resting8.2104e-030.3698image
ENSG00000168872.14,DDX19AESCAEAGMacrophages_M13.3379e-02-0.1952image
ENSG00000168872.14,DDX19AGBMEAGDendritic_cells_activated4.9837e-02-0.1573image
ENSG00000168872.14,DDX19AHNSCEAGT_cells_CD4_memory_resting4.7668e-02-0.2059image
ENSG00000168872.14,DDX19AKIRCEAGNK_cells_resting3.3176e-020.1735image
ENSG00000168872.14,DDX19AKIRPEAGB_cells_memory2.6192e-020.2293image
ENSG00000168872.14,DDX19ALAMLEAGDendritic_cells_resting2.3092e-020.3032image
ENSG00000168872.14,DDX19ALGGEAGDendritic_cells_activated3.4173e-02-0.1004image
ENSG00000168872.14,DDX19ALIHCEAGDendritic_cells_resting7.4332e-030.2006image
ENSG00000168872.14,DDX19ALUADEAGB_cells_naive3.2411e-030.1905image
ENSG00000168872.14,DDX19ALUSCEAGB_cells_naive1.1559e-020.2308image
chr16:70361826-70362321:+OVEERMast_cells_resting4.5572e-030.4959image
ENSG00000168872.14,DDX19AOVEAGT_cells_gamma_delta1.1870e-030.2311image
ENSG00000168872.14,DDX19APAADEAGT_cells_regulatory_(Tregs)7.9801e-03-0.2843image
ENSG00000168872.14,DDX19APRADEAGDendritic_cells_activated1.2663e-110.4175image
ENSG00000168872.14,DDX19ASARCEAGT_cells_regulatory_(Tregs)7.2527e-030.2363image
ENSG00000168872.14,DDX19ASKCMEAGT_cells_CD4_naive1.9113e-030.2498image
ENSG00000168872.14,DDX19ASTADEAGMacrophages_M28.6382e-03-0.1592image
ENSG00000168872.14,DDX19ATHCAEAGDendritic_cells_resting2.3486e-020.1702image
ENSG00000168872.14,DDX19ATHYMEAGNeutrophils4.3652e-02-0.2809image
ENSG00000168872.14,DDX19AUCECEAGT_cells_regulatory_(Tregs)3.0977e-020.3334image


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6. Enriched editing regions and immune gene sets for DDX19A


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000168872.14,DDX19ASKCMEAG5.7818e-03-0.22291.2837e-02-0.20148.0585e-03-0.21428.9860e-03-0.2113image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000168872.14,DDX19AACCGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG1.5704e-02-0.4445image
ENSG00000168872.14,DDX19ABLCAGSVA_HALLMARK_GLYCOLYSISEAG1.9192e-05-0.4636image
ENSG00000168872.14,DDX19ABRCAGSVA_HALLMARK_UV_RESPONSE_UPEAG5.6811e-03-0.1132image
ENSG00000168872.14,DDX19ACESCGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.2855e-02-0.3214image
ENSG00000168872.14,DDX19ACOADGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG1.1214e-05-0.6406image
chr16:70361826-70362321:+ESCAGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER3.8944e-020.2930image
ENSG00000168872.14,DDX19AESCAGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.2558e-03-0.2923image
ENSG00000168872.14,DDX19AGBMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.4455e-020.1955image
ENSG00000168872.14,DDX19AHNSCGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.0876e-02-0.2630image
ENSG00000168872.14,DDX19AKIRCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG1.3182e-03-0.2591image
ENSG00000168872.14,DDX19AKIRPGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG5.6500e-04-0.3490image
ENSG00000168872.14,DDX19ALAMLGSVA_HALLMARK_BILE_ACID_METABOLISMEAG7.7789e-03-0.3521image
ENSG00000168872.14,DDX19ALGGGSVA_HALLMARK_DNA_REPAIREAG2.6013e-05-0.1980image
ENSG00000168872.14,DDX19ALIHCGSVA_HALLMARK_MYC_TARGETS_V2EAG2.4563e-02-0.1690image
ENSG00000168872.14,DDX19ALUADGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG1.6553e-05-0.2758image
ENSG00000168872.14,DDX19ALUSCGSVA_HALLMARK_NOTCH_SIGNALINGEAG1.5314e-02-0.2218image
ENSG00000168872.14,DDX19AMESOGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.3198e-020.4335image
ENSG00000168872.14,DDX19APAADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.4608e-04-0.3705image
ENSG00000168872.14,DDX19APRADGSVA_HALLMARK_PEROXISOMEEAG1.7273e-05-0.2724image
ENSG00000168872.14,DDX19ASARCGSVA_HALLMARK_ANGIOGENESISEAG2.8038e-03-0.2621image
ENSG00000168872.14,DDX19ASKCMGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG1.2911e-03-0.2587image
ENSG00000168872.14,DDX19ASTADGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.9455e-04-0.2245image
ENSG00000168872.14,DDX19ATHCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.0382e-02-0.1922image
ENSG00000168872.14,DDX19ATHYMGSVA_HALLMARK_UV_RESPONSE_DNEAG1.0488e-020.3520image
ENSG00000168872.14,DDX19AUCECGSVA_HALLMARK_SPERMATOGENESISEAG7.0982e-04-0.5018image


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7. Enriched editing regions and drugs for DDX19A


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000168872.14,DDX19AACCGW.441756EAG1.7445e-02-0.4381image
ENSG00000168872.14,DDX19ABLCACCT007093EAG1.2346e-03-0.3593image
ENSG00000168872.14,DDX19ABRCACCT007093EAG2.5840e-03-0.1233image
ENSG00000168872.14,DDX19ACESCBIRB.0796EAG2.6298e-02-0.3142image
ENSG00000168872.14,DDX19ACOADGW843682XEAG9.9903e-100.7999image
chr16:70361826-70362321:+ESCAAUY922EER3.2139e-02-0.3035image
ENSG00000168872.14,DDX19AESCABMS.708163EAG3.5010e-02-0.1935image
ENSG00000168872.14,DDX19AGBMAZD6244EAG4.5472e-030.2260image
ENSG00000168872.14,DDX19AHNSCAZD6482EAG3.5561e-040.3625image
ENSG00000168872.14,DDX19AKIRCAZ628EAG2.9447e-03-0.2404image
ENSG00000168872.14,DDX19AKIRPElesclomolEAG3.2400e-030.3006image
ENSG00000168872.14,DDX19ALAMLJNK.9LEAG5.6510e-040.4463image
ENSG00000168872.14,DDX19ALGGCGP.082996EAG4.3700e-070.2367image
ENSG00000168872.14,DDX19ALIHCBMS.509744EAG4.2293e-020.1528image
ENSG00000168872.14,DDX19ALUADBexaroteneEAG8.3806e-030.1709image
ENSG00000168872.14,DDX19ALUSCMidostaurinEAG3.0989e-02-0.1979image
ENSG00000168872.14,DDX19AOVAZD6244EAG4.6136e-020.1434image
chr16:70361826-70362321:+OVKU.55933EER3.7077e-020.3760image
ENSG00000168872.14,DDX19APAADImatinibEAG1.1374e-02-0.2766image
ENSG00000168872.14,DDX19APCPGDasatinibEAG2.6173e-020.1792image
ENSG00000168872.14,DDX19APRADLenalidomideEAG1.1770e-09-0.3784image
ENSG00000168872.14,DDX19ASARCBIBW2992EAG3.1457e-03-0.2591image
ENSG00000168872.14,DDX19ASKCMEmbelinEAG2.6116e-030.2425image
ENSG00000168872.14,DDX19ASTADCMKEAG8.4037e-03-0.1598image
ENSG00000168872.14,DDX19ATHCAIPA.3EAG1.0172e-020.1927image
ENSG00000168872.14,DDX19ATHYMCHIR.99021EAG4.6172e-03-0.3868image
ENSG00000168872.14,DDX19AUCECAMG.706EAG1.1050e-03-0.4859image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType