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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: UBE2W (ImmuneEditome ID:55284)

1. Gene summary of enriched editing regions for UBE2W

check button Gene summary
Gene informationGene symbol

UBE2W

Gene ID

55284

GeneSynonymsUBC-16|UBC16
GeneCytomap

8q21.11

GeneTypeprotein-coding
GeneDescriptionubiquitin-conjugating enzyme E2 W|E2 ubiquitin-conjugating enzyme W|N-terminal E2 ubiquitin-conjugating enzyme|N-terminus-conjugating E2|ubiquitin carrier protein W|ubiquitin conjugating enzyme E2 W (putative)|ubiquitin conjugating enzyme E2W (putative)|ubiquitin-conjugating enzyme 16|ubiquitin-conjugating enzyme 2W|ubiquitin-protein ligase W
GeneModificationdate20230405
UniprotIDQ96B02;X6REH9;E5RG25;A0A024R7X9
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr8:73798124-73798324:-ENST00000419880.6ENSG00000104343.18UBE2WintronicAluJb,Tigger4bchr8:73798124-73798324:-.alignment
chr8:73798124-73798324:-ENST00000422906.5ENSG00000104343.18UBE2WintronicAluJb,Tigger4bchr8:73798124-73798324:-.alignment
chr8:73798124-73798324:-ENST00000517608.4ENSG00000104343.18UBE2WintronicAluJb,Tigger4bchr8:73798124-73798324:-.alignment
chr8:73798124-73798324:-ENST00000519255.2ENSG00000104343.18UBE2WintronicAluJb,Tigger4bchr8:73798124-73798324:-.alignment
chr8:73798124-73798324:-ENST00000519277.4ENSG00000104343.18UBE2WintronicAluJb,Tigger4bchr8:73798124-73798324:-.alignment
chr8:73798124-73798324:-ENST00000523278.4ENSG00000104343.18UBE2WintronicAluJb,Tigger4bchr8:73798124-73798324:-.alignment
chr8:73798124-73798324:-ENST00000602593.4ENSG00000104343.18UBE2WintronicAluJb,Tigger4bchr8:73798124-73798324:-.alignment
chr8:73803856-73805259:-ENST00000419880.6ENSG00000104343.18UBE2WintronicAluSz,AluY,AluSpchr8:73803856-73805259:-.alignment
chr8:73803856-73805259:-ENST00000422906.5ENSG00000104343.18UBE2WintronicAluSz,AluY,AluSpchr8:73803856-73805259:-.alignment
chr8:73803856-73805259:-ENST00000517608.4ENSG00000104343.18UBE2WintronicAluSz,AluY,AluSpchr8:73803856-73805259:-.alignment
chr8:73803856-73805259:-ENST00000519255.2ENSG00000104343.18UBE2WintronicAluSz,AluY,AluSpchr8:73803856-73805259:-.alignment
chr8:73803856-73805259:-ENST00000519277.4ENSG00000104343.18UBE2WintronicAluSz,AluY,AluSpchr8:73803856-73805259:-.alignment
chr8:73803856-73805259:-ENST00000523278.4ENSG00000104343.18UBE2WintronicAluSz,AluY,AluSpchr8:73803856-73805259:-.alignment
chr8:73803856-73805259:-ENST00000602593.4ENSG00000104343.18UBE2WintronicAluSz,AluY,AluSpchr8:73803856-73805259:-.alignment
chr8:73815098-73815238:-ENST00000419880.6ENSG00000104343.18UBE2WintronicAluJochr8:73815098-73815238:-.alignment
chr8:73815098-73815238:-ENST00000422906.5ENSG00000104343.18UBE2WintronicAluJochr8:73815098-73815238:-.alignment
chr8:73815098-73815238:-ENST00000517608.4ENSG00000104343.18UBE2WintronicAluJochr8:73815098-73815238:-.alignment
chr8:73815098-73815238:-ENST00000519255.2ENSG00000104343.18UBE2WintronicAluJochr8:73815098-73815238:-.alignment
chr8:73815098-73815238:-ENST00000519277.4ENSG00000104343.18UBE2WintronicAluJochr8:73815098-73815238:-.alignment
chr8:73815098-73815238:-ENST00000523278.4ENSG00000104343.18UBE2WintronicAluJochr8:73815098-73815238:-.alignment
chr8:73815098-73815238:-ENST00000602593.4ENSG00000104343.18UBE2WintronicAluJochr8:73815098-73815238:-.alignment
chr8:73853388-73854031:-ENST00000419880.6ENSG00000104343.18UBE2WintronicAluJb,AluJr,A-richchr8:73853388-73854031:-.alignment
chr8:73853388-73854031:-ENST00000422906.5ENSG00000104343.18UBE2WintronicAluJb,AluJr,A-richchr8:73853388-73854031:-.alignment
chr8:73853388-73854031:-ENST00000517608.4ENSG00000104343.18UBE2WintronicAluJb,AluJr,A-richchr8:73853388-73854031:-.alignment
chr8:73853388-73854031:-ENST00000519255.2ENSG00000104343.18UBE2WintronicAluJb,AluJr,A-richchr8:73853388-73854031:-.alignment
chr8:73853388-73854031:-ENST00000519277.4ENSG00000104343.18UBE2WintronicAluJb,AluJr,A-richchr8:73853388-73854031:-.alignment
chr8:73853388-73854031:-ENST00000602593.4ENSG00000104343.18UBE2WintronicAluJb,AluJr,A-richchr8:73853388-73854031:-.alignment
chr8:73855420-73856951:-ENST00000419880.6ENSG00000104343.18UBE2WintronicAluSz,Tigger2b_Pri,AluSz6chr8:73855420-73856951:-.alignment
chr8:73855420-73856951:-ENST00000422906.5ENSG00000104343.18UBE2WintronicAluSz,Tigger2b_Pri,AluSz6chr8:73855420-73856951:-.alignment
chr8:73855420-73856951:-ENST00000517608.4ENSG00000104343.18UBE2WintronicAluSz,Tigger2b_Pri,AluSz6chr8:73855420-73856951:-.alignment
chr8:73855420-73856951:-ENST00000519255.2ENSG00000104343.18UBE2WintronicAluSz,Tigger2b_Pri,AluSz6chr8:73855420-73856951:-.alignment
chr8:73855420-73856951:-ENST00000519277.4ENSG00000104343.18UBE2WintronicAluSz,Tigger2b_Pri,AluSz6chr8:73855420-73856951:-.alignment
chr8:73855420-73856951:-ENST00000602593.4ENSG00000104343.18UBE2WintronicAluSz,Tigger2b_Pri,AluSz6chr8:73855420-73856951:-.alignment
chr8:73859239-73859746:-ENST00000419880.6ENSG00000104343.18UBE2WintronicAluSz,Tigger2achr8:73859239-73859746:-.alignment
chr8:73859239-73859746:-ENST00000422906.5ENSG00000104343.18UBE2WintronicAluSz,Tigger2achr8:73859239-73859746:-.alignment
chr8:73859239-73859746:-ENST00000517608.4ENSG00000104343.18UBE2WintronicAluSz,Tigger2achr8:73859239-73859746:-.alignment
chr8:73859239-73859746:-ENST00000519255.2ENSG00000104343.18UBE2WintronicAluSz,Tigger2achr8:73859239-73859746:-.alignment
chr8:73859239-73859746:-ENST00000519277.4ENSG00000104343.18UBE2WintronicAluSz,Tigger2achr8:73859239-73859746:-.alignment
chr8:73859239-73859746:-ENST00000602593.4ENSG00000104343.18UBE2WintronicAluSz,Tigger2achr8:73859239-73859746:-.alignment
chr8:73872972-73873663:-ENST00000419880.6ENSG00000104343.18UBE2WintronicAluSx,AluJbchr8:73872972-73873663:-.alignment
chr8:73872972-73873663:-ENST00000422906.5ENSG00000104343.18UBE2WintronicAluSx,AluJbchr8:73872972-73873663:-.alignment
chr8:73872972-73873663:-ENST00000517608.4ENSG00000104343.18UBE2WintronicAluSx,AluJbchr8:73872972-73873663:-.alignment
chr8:73872972-73873663:-ENST00000519255.2ENSG00000104343.18UBE2WintronicAluSx,AluJbchr8:73872972-73873663:-.alignment
chr8:73872972-73873663:-ENST00000519277.4ENSG00000104343.18UBE2WintronicAluSx,AluJbchr8:73872972-73873663:-.alignment
chr8:73872972-73873663:-ENST00000602593.4ENSG00000104343.18UBE2WintronicAluSx,AluJbchr8:73872972-73873663:-.alignment


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2. Tumor-specific enriched editing regions for UBE2W


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr8:73872972-73873663:-STADPathEER3.2695e-022.5363e-020.1695image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr8:73855420-73856951:-OVEER9.6511e-034.1994e-024.3575e-04image

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3. Enriched editing regions and immune related genes for UBE2W


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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4. Enriched editing regions and immune related splicing for UBE2W


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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5. Enriched editing regions and immune infiltration for UBE2W


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000104343.18,UBE2WBRCAEAGMacrophages_M11.4090e-02-0.4234image
chr8:73859239-73859746:-ESCAEERB_cells_memory1.1398e-02-0.4632image
chr8:73815098-73815238:-LAMLEEREosinophils1.1474e-02-0.3548image
chr8:73853388-73854031:-LAMLEERB_cells_naive4.1205e-03-0.4195image
chr8:73859239-73859746:-LAMLEERNK_cells_resting7.5595e-030.3416image
ENSG00000104343.18,UBE2WLUADEAGT_cells_CD4_memory_resting1.5014e-03-0.6228image
chr8:73872972-73873663:-OVEERPlasma_cells1.5292e-020.4619image
ENSG00000104343.18,UBE2WPRADEAGT_cells_CD4_memory_activated6.6748e-040.6339image
chr8:73872972-73873663:-STADEERMacrophages_M01.7027e-03-0.2342image
ENSG00000104343.18,UBE2WSTADEAGMacrophages_M04.7482e-04-0.2505image


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6. Enriched editing regions and immune gene sets for UBE2W


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000104343.18,UBE2WLUADEAG3.6420e-040.67931.3645e-020.50654.6557e-030.56842.2123e-020.4746image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr8:73872972-73873663:-ESCAGSVA_HALLMARK_APICAL_SURFACEEER2.0179e-020.2432image
ENSG00000104343.18,UBE2WESCAGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG2.2228e-020.2332image
chr8:73859239-73859746:-LAMLGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER3.7781e-030.3684image
ENSG00000104343.18,UBE2WLAMLGSVA_HALLMARK_P53_PATHWAYEAG3.2997e-030.2673image
chr8:73853388-73854031:-LAMLGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER9.2524e-030.3838image
ENSG00000104343.18,UBE2WLUADGSVA_HALLMARK_MTORC1_SIGNALINGEAG1.9052e-030.6122image
ENSG00000104343.18,UBE2WOVGSVA_HALLMARK_SPERMATOGENESISEAG3.9314e-02-0.3314image
ENSG00000104343.18,UBE2WPRADGSVA_HALLMARK_E2F_TARGETSEAG1.3528e-020.4871image
chr8:73855420-73856951:-PRADGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER2.5337e-030.6108image
chr8:73803856-73805259:-STADGSVA_HALLMARK_ANGIOGENESISEER1.0779e-030.4816image
chr8:73855420-73856951:-STADGSVA_HALLMARK_APICAL_SURFACEEER2.4521e-030.3695image
chr8:73872972-73873663:-STADGSVA_HALLMARK_HEME_METABOLISMEER1.9354e-020.1757image
ENSG00000104343.18,UBE2WSTADGSVA_HALLMARK_ANDROGEN_RESPONSEEAG3.0397e-030.2134image


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7. Enriched editing regions and drugs for UBE2W


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr8:73859239-73859746:-ESCAImatinibEER1.7260e-02-0.4388image
chr8:73872972-73873663:-ESCACHIR.99021EER3.0982e-03-0.3068image
ENSG00000104343.18,UBE2WESCAImatinibEAG1.5010e-03-0.3196image
chr8:73815098-73815238:-LAMLBMS.708163EER3.1551e-02-0.3045image
chr8:73859239-73859746:-LAMLAZ628EER3.4288e-03-0.3720image
chr8:73872972-73873663:-LAMLKIN001.135EER1.5234e-02-0.3415image
ENSG00000104343.18,UBE2WLAMLCisplatinEAG4.1463e-030.2610image
chr8:73853388-73854031:-LAMLCMKEER9.1068e-030.3845image
ENSG00000104343.18,UBE2WLUADCEP.701EAG8.0649e-05-0.7286image
chr8:73872972-73873663:-OVAxitinibEER5.5233e-03-0.5191image
ENSG00000104343.18,UBE2WOVGDC.0449EAG4.8684e-03-0.4418image
ENSG00000104343.18,UBE2WPRADKU.55933EAG8.9092e-03-0.5118image
chr8:73855420-73856951:-PRADLFM.A13EER1.1921e-020.5260image
chr8:73803856-73805259:-STADFTI.277EER7.8057e-04-0.4931image
chr8:73872972-73873663:-STADCCT018159EER2.2675e-02-0.1712image
ENSG00000104343.18,UBE2WSTADJNJ.26854165EAG2.3003e-03-0.2193image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType