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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: TMEM19 (ImmuneEditome ID:55266)

1. Gene summary of enriched editing regions for TMEM19

check button Gene summary
Gene informationGene symbol

TMEM19

Gene ID

55266

GeneSynonyms-
GeneCytomap

12q21.1

GeneTypeprotein-coding
GeneDescriptiontransmembrane protein 19
GeneModificationdate20230329
UniprotIDQ96HH6;A0A024RBE1;H0YIS8;A0A024RBA1;F8VRE8;F8VS20
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr12:71702347-71703175:+ENST00000266673.8ENSG00000139291.12TMEM19UTR3AluSz6,AluSz,MER5Bchr12:71702347-71703175:+.alignment


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2. Tumor-specific enriched editing regions for TMEM19


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr12:71702347-71703175:+BRCAEER2.2438e-03image
ENSG00000139291.12,TMEM19BRCAEAG2.1650e-03image
chr12:71702347-71703175:+KICHEER3.6019e-06image
ENSG00000139291.12,TMEM19KICHEAG3.6019e-06image
chr12:71702347-71703175:+KIRPEER3.4105e-02image
ENSG00000139291.12,TMEM19KIRPEAG3.5004e-02image
chr12:71702347-71703175:+LUSCEER2.3470e-03image
ENSG00000139291.12,TMEM19LUSCEAG2.3470e-03image
chr12:71702347-71703175:+THCAEER3.3830e-02image
ENSG00000139291.12,TMEM19THCAEAG3.4039e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr12:71702347-71703175:+LGGEER2.9121e-024.4684e-022.0155e-01image
ENSG00000139291.12,TMEM19LGGEAG2.9121e-024.3061e-021.9905e-01image

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3. Enriched editing regions and immune related genes for TMEM19


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr12:71702347-71703175:+CESCEERENSG00000131019,ULBP30.33283.7057e-068.6280e-140.4156imageNNULBP3Mast_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr12:71702347-71703175:+CESCEERENSG00000140836,ZFHX30.27752.3840e-041.8518e-130.4105imageNNNAMacrophages_M0GSVA_HALLMARK_P53_PATHWAY
chr12:71702347-71703175:+GBMEERENSG00000183199,HSP90AB3P0.38272.0053e-045.8822e-100.4585imageNNNAMacrophages_M0GSVA_HALLMARK_G2M_CHECKPOINT
chr12:71702347-71703175:+GBMEERENSG00000216866,RPS2P550.34541.1688e-031.7966e-090.4468imageNNNANeutrophilsGSVA_HALLMARK_MYC_TARGETS_V1
chr12:71702347-71703175:+GBMEERENSG00000228887,EEF1DP10.32942.5583e-039.8745e-080.4004imageNNNAGSVA_HALLMARK_MYC_TARGETS_V1
chr12:71702347-71703175:+GBMEERENSG00000223668,EEF1A1P240.32143.0637e-036.2764e-090.4330imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_KRAS_SIGNALING_DN
chr12:71702347-71703175:+GBMEERENSG00000243014,PTMAP80.32113.4142e-035.3306e-080.4080imageNNNAT_cells_follicular_helperGSVA_HALLMARK_E2F_TARGETS
chr12:71702347-71703175:+GBMEERENSG00000248415,GAPDHP610.31163.7511e-032.9143e-080.4153imageNNNAMacrophages_M0GSVA_HALLMARK_GLYCOLYSIS
chr12:71702347-71703175:+GBMEERENSG00000127589,TUBBP10.30805.3662e-038.5015e-080.4023imageNNNAMacrophages_M0GSVA_HALLMARK_G2M_CHECKPOINT
chr12:71702347-71703175:+GBMEERENSG00000250568,RP11-333E13.20.30456.2245e-039.4549e-080.4010imageNNNAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASIS

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4. Enriched editing regions and immune related splicing for TMEM19


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000139291.12,TMEM19
CESCEAGIRENSG00000136305.7chr1424305095:24305765:24305946:243061370.39319.4308e-083.1736e-160.4515imageNBCCIP;EIF4A3;FAM120A;FUS;GTF2F1;HNRNPA1;HNRNPC;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP3;LIN28B;MSI2;PCBP2;PRPF8;RBFOX2;SND1;SRSF1;SRSF3;SRSF9;TAF15;TIA1;U2AF1;UPF1;YTHDF1CIDEBMacrophages_M0GSVA_HALLMARK_PROTEIN_SECRETION
ENSG00000139291.12,TMEM19
CESCEAGIRENSG00000136305.7chr1424305095:24306137:24306373:243064610.38851.3356e-078.6199e-170.4599imageNBCCIP;EIF4A3;FAM120A;FUS;GTF2F1;HNRNPA1;HNRNPC;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP3;LIN28B;MSI2;PCBP2;PRPF8;RBFOX2;SND1;SRSF1;SRSF3;SRSF9;TAF15;TIA1;U2AF1;UPF1;YTHDF1CIDEBMacrophages_M0GSVA_HALLMARK_PROTEIN_SECRETION
chr12:71702347-71703175:+
CESCEERIRENSG00000136305.7chr1424305095:24305765:24305946:243061370.39321.5657e-073.1359e-160.4516imageNNCIDEBMacrophages_M0GSVA_HALLMARK_PROTEIN_SECRETION
chr12:71702347-71703175:+
CESCEERIRENSG00000136305.7chr1424305095:24306137:24306373:243064610.38931.9975e-078.3289e-170.4601imageNNCIDEBMacrophages_M0GSVA_HALLMARK_PROTEIN_SECRETION
ENSG00000139291.12,TMEM19
CESCEAGIRENSG00000136305.7chr1424305095:24306523:24307370:243075150.33582.0093e-059.0075e-130.4014imageNBCCIP;EIF4A3;FAM120A;FUS;GTF2F1;HNRNPA1;HNRNPC;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP3;LIN28B;MSI2;PCBP2;PRPF8;RBFOX2;SND1;SRSF1;SRSF3;SRSF9;TAF15;TIA1;U2AF1;UPF1;YTHDF1CIDEBMacrophages_M0GSVA_HALLMARK_P53_PATHWAY
chr12:71702347-71703175:+
CESCEERIRENSG00000136305.7chr1424305095:24306523:24307370:243075150.33562.4736e-059.0075e-130.4014imageNNCIDEBMacrophages_M0GSVA_HALLMARK_P53_PATHWAY
ENSG00000139291.12,TMEM19
DLBCEAGIRENSG00000182944.13chr2229298732:29299280:29299598:29299616-0.63443.0322e-021.7943e-04-0.5151imageNACIN1;ADAR;BCCIP;CELF2;CNBP;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM27;RBM47;SAFB2;SND1;SRSF1;SRSF3;SRSF9;TAF15;TARDBP;TIA1;TIAL1;U2AF1;U2AF2;UPF1;YTHDC1;YTHDF1;ZC3H7B;ZNF184NADendritic_cells_restingGSVA_HALLMARK_SPERMATOGENESIS
chr12:71702347-71703175:+
DLBCEERIRENSG00000182944.13chr2229298732:29299280:29299598:29299616-0.63443.3070e-021.7943e-04-0.5151imageNNNADendritic_cells_restingGSVA_HALLMARK_SPERMATOGENESIS
chr12:71702347-71703175:+
ESCAEERIRENSG00000103111.10chr1677193436:77193789:77194334:77194360-0.31092.3523e-025.0211e-07-0.4017imageNNNAMacrophages_M2GSVA_HALLMARK_GLYCOLYSIS
ENSG00000139291.12,TMEM19
ESCAEAGIRENSG00000103111.10chr1677193436:77193789:77194334:77194360-0.31082.8115e-025.1918e-07-0.4012imageNACIN1;ADAR;BCCIP;CELF2;CNBP;DDX3X;DDX54;DGCR8;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM27;RBM47;RC3H1;SAFB2;SND1;SRSF1;SRSF3;SRSF9;TAF15;TARDBP;TIA1;U2AF1;U2AF2;UPF1;YTHDC1;YTHDF1;ZC3H7B;ZNF184NAMacrophages_M2GSVA_HALLMARK_GLYCOLYSIS

More results



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5. Enriched editing regions and immune infiltration for TMEM19


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr12:71702347-71703175:+ACCEERMacrophages_M22.1826e-02-0.2798image
ENSG00000139291.12,TMEM19ACCEAGMacrophages_M21.7524e-02-0.2894image
chr12:71702347-71703175:+BLCAEERMacrophages_M19.7089e-04-0.1695image
ENSG00000139291.12,TMEM19BLCAEAGMacrophages_M19.7172e-04-0.1694image
chr12:71702347-71703175:+BRCAEERT_cells_regulatory_(Tregs)1.3186e-05-0.1336image
ENSG00000139291.12,TMEM19BRCAEAGT_cells_regulatory_(Tregs)1.3044e-05-0.1337image
chr12:71702347-71703175:+CESCEERMacrophages_M09.4016e-060.2544image
ENSG00000139291.12,TMEM19CESCEAGMacrophages_M09.3736e-060.2544image
chr12:71702347-71703175:+CHOLEERNeutrophils5.2059e-030.4620image
ENSG00000139291.12,TMEM19CHOLEAGNeutrophils5.2059e-030.4620image
chr12:71702347-71703175:+COADEERB_cells_memory2.7695e-03-0.1856image
ENSG00000139291.12,TMEM19COADEAGB_cells_memory2.8050e-03-0.1853image
chr12:71702347-71703175:+DLBCEERMonocytes3.5817e-020.3038image
ENSG00000139291.12,TMEM19DLBCEAGMonocytes3.5817e-020.3038image
chr12:71702347-71703175:+ESCAEERMacrophages_M22.8157e-030.2340image
ENSG00000139291.12,TMEM19ESCAEAGMacrophages_M22.8179e-030.2340image
chr12:71702347-71703175:+GBMEERMacrophages_M02.3535e-020.1763image
ENSG00000139291.12,TMEM19GBMEAGMacrophages_M02.3535e-020.1763image
chr12:71702347-71703175:+HNSCEERMacrophages_M15.9991e-04-0.1539image
ENSG00000139291.12,TMEM19HNSCEAGMacrophages_M16.1781e-04-0.1535image
chr12:71702347-71703175:+KIRCEERT_cells_CD4_memory_activated5.3594e-03-0.1426image
ENSG00000139291.12,TMEM19KIRCEAGT_cells_CD4_memory_activated5.3716e-03-0.1425image
chr12:71702347-71703175:+KIRPEERB_cells_memory1.9828e-02-0.1384image
ENSG00000139291.12,TMEM19KIRPEAGT_cells_CD4_memory_resting1.9849e-020.1384image
chr12:71702347-71703175:+LAMLEERT_cells_CD4_memory_resting1.3268e-02-0.3983image
ENSG00000139291.12,TMEM19LAMLEAGT_cells_CD4_memory_resting1.3268e-02-0.3983image
chr12:71702347-71703175:+LGGEERT_cells_CD4_naive9.9763e-070.2118image
ENSG00000139291.12,TMEM19LGGEAGT_cells_CD4_naive9.7013e-070.2120image
chr12:71702347-71703175:+LIHCEERB_cells_memory2.6685e-030.1638image
ENSG00000139291.12,TMEM19LIHCEAGB_cells_memory2.5975e-030.1643image
chr12:71702347-71703175:+LUADEERMacrophages_M19.5585e-03-0.1172image
ENSG00000139291.12,TMEM19LUADEAGMacrophages_M11.0077e-02-0.1164image
chr12:71702347-71703175:+LUSCEERMacrophages_M13.4978e-03-0.1328image
ENSG00000139291.12,TMEM19LUSCEAGMacrophages_M13.4978e-03-0.1328image
chr12:71702347-71703175:+MESOEERB_cells_memory3.0182e-040.3915image
ENSG00000139291.12,TMEM19MESOEAGB_cells_memory3.0182e-040.3915image
chr12:71702347-71703175:+OVEERT_cells_gamma_delta1.6076e-02-0.1410image
ENSG00000139291.12,TMEM19OVEAGT_cells_gamma_delta1.6447e-02-0.1405image
chr12:71702347-71703175:+PAADEERNK_cells_resting2.7981e-02-0.1676image
ENSG00000139291.12,TMEM19PAADEAGNK_cells_resting2.7981e-02-0.1676image
chr12:71702347-71703175:+PCPGEERPlasma_cells1.2214e-02-0.1864image
ENSG00000139291.12,TMEM19PCPGEAGPlasma_cells1.2356e-02-0.1861image
chr12:71702347-71703175:+PRADEERDendritic_cells_resting1.3320e-020.1207image
ENSG00000139291.12,TMEM19PRADEAGDendritic_cells_resting1.3361e-020.1206image
chr12:71702347-71703175:+READEERT_cells_CD4_memory_activated2.0799e-030.3204image
ENSG00000139291.12,TMEM19READEAGT_cells_CD4_memory_activated2.0799e-030.3204image
chr12:71702347-71703175:+SARCEERMacrophages_M04.3746e-030.1800image
ENSG00000139291.12,TMEM19SARCEAGMacrophages_M04.3999e-030.1799image
chr12:71702347-71703175:+SKCMEERT_cells_CD81.2385e-04-0.1816image
ENSG00000139291.12,TMEM19SKCMEAGT_cells_CD81.2438e-04-0.1815image
chr12:71702347-71703175:+STADEERT_cells_CD4_naive4.5406e-050.2123image
ENSG00000139291.12,TMEM19STADEAGT_cells_CD4_naive4.5484e-050.2123image
chr12:71702347-71703175:+TGCTEERT_cells_CD4_naive5.7330e-040.3137image
ENSG00000139291.12,TMEM19TGCTEAGT_cells_CD4_naive5.7330e-040.3137image
chr12:71702347-71703175:+THCAEERT_cells_gamma_delta1.1704e-02-0.1131image
ENSG00000139291.12,TMEM19THCAEAGT_cells_gamma_delta1.1801e-02-0.1130image
chr12:71702347-71703175:+THYMEERT_cells_CD4_naive3.7566e-020.1925image
ENSG00000139291.12,TMEM19THYMEAGT_cells_CD4_naive3.7566e-020.1925image
chr12:71702347-71703175:+UCSEERMonocytes3.7412e-040.4836image
ENSG00000139291.12,TMEM19UCSEAGMonocytes3.7412e-040.4836image
chr12:71702347-71703175:+UVMEEREosinophils5.9453e-030.3377image
ENSG00000139291.12,TMEM19UVMEAGEosinophils5.9453e-030.3377image


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6. Enriched editing regions and immune gene sets for TMEM19


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000139291.12,TMEM19ACCGSVA_HALLMARK_E2F_TARGETSEAG3.6516e-020.2560image
chr12:71702347-71703175:+ACCGSVA_HALLMARK_KRAS_SIGNALING_DNEER3.8895e-02-0.2530image
chr12:71702347-71703175:+BLCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.7359e-04-0.1768image
ENSG00000139291.12,TMEM19BLCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG5.7383e-04-0.1768image
chr12:71702347-71703175:+BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.8763e-16-0.2480image
ENSG00000139291.12,TMEM19BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.4342e-16-0.2486image
chr12:71702347-71703175:+CESCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.3716e-060.2764image
ENSG00000139291.12,TMEM19CESCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.3911e-060.2762image
chr12:71702347-71703175:+ESCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER5.3230e-050.3129image
ENSG00000139291.12,TMEM19ESCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG5.2887e-050.3130image
chr12:71702347-71703175:+GBMGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER5.2272e-030.2165image
ENSG00000139291.12,TMEM19GBMGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG5.2272e-030.2165image
chr12:71702347-71703175:+HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER6.3037e-06-0.2016image
ENSG00000139291.12,TMEM19HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.3651e-06-0.2015image
chr12:71702347-71703175:+KICHGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER1.6244e-020.2994image
ENSG00000139291.12,TMEM19KICHGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG1.6244e-020.2994image
chr12:71702347-71703175:+KIRCGSVA_HALLMARK_DNA_REPAIREER1.5381e-030.1619image
ENSG00000139291.12,TMEM19KIRCGSVA_HALLMARK_DNA_REPAIREAG1.6784e-030.1607image
ENSG00000139291.12,TMEM19KIRPGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.5872e-070.3004image
chr12:71702347-71703175:+KIRPGSVA_HALLMARK_PROTEIN_SECRETIONEER2.4006e-070.3012image
ENSG00000139291.12,TMEM19LAMLGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG1.6342e-020.3871image
chr12:71702347-71703175:+LAMLGSVA_HALLMARK_TGF_BETA_SIGNALINGEER1.6342e-020.3871image
ENSG00000139291.12,TMEM19LGGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG7.2346e-21-0.3936image
chr12:71702347-71703175:+LGGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER7.9244e-21-0.3933image
chr12:71702347-71703175:+LIHCGSVA_HALLMARK_UV_RESPONSE_DNEER1.0388e-030.1787image
ENSG00000139291.12,TMEM19LIHCGSVA_HALLMARK_UV_RESPONSE_DNEAG1.1910e-030.1766image
ENSG00000139291.12,TMEM19LUADGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.3162e-020.1122image
chr12:71702347-71703175:+LUADGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.3367e-020.1119image
ENSG00000139291.12,TMEM19LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG9.3987e-09-0.2577image
chr12:71702347-71703175:+LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER9.3987e-09-0.2577image
chr12:71702347-71703175:+OVGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER3.5886e-040.2078image
ENSG00000139291.12,TMEM19OVGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG3.7589e-040.2071image
ENSG00000139291.12,TMEM19PAADGSVA_HALLMARK_P53_PATHWAYEAG2.9040e-03-0.2258image
chr12:71702347-71703175:+PAADGSVA_HALLMARK_P53_PATHWAYEER2.9040e-03-0.2258image
chr12:71702347-71703175:+PCPGGSVA_HALLMARK_UV_RESPONSE_DNEER5.8908e-040.2537image
ENSG00000139291.12,TMEM19PCPGGSVA_HALLMARK_UV_RESPONSE_DNEAG6.0460e-040.2532image
ENSG00000139291.12,TMEM19PRADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG2.5957e-030.1466image
chr12:71702347-71703175:+PRADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER2.6003e-030.1466image
chr12:71702347-71703175:+READGSVA_HALLMARK_TGF_BETA_SIGNALINGEER4.4612e-030.2971image
ENSG00000139291.12,TMEM19READGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG4.4612e-030.2971image
chr12:71702347-71703175:+SARCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.0800e-05-0.2749image
ENSG00000139291.12,TMEM19SARCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.0525e-05-0.2752image
chr12:71702347-71703175:+SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER6.4625e-08-0.2536image
ENSG00000139291.12,TMEM19SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.4949e-08-0.2536image
ENSG00000139291.12,TMEM19STADGSVA_HALLMARK_UV_RESPONSE_UPEAG1.3160e-030.1680image
chr12:71702347-71703175:+STADGSVA_HALLMARK_UV_RESPONSE_UPEER1.3192e-030.1679image
ENSG00000139291.12,TMEM19TGCTGSVA_HALLMARK_BILE_ACID_METABOLISMEAG5.3115e-040.3155image
chr12:71702347-71703175:+TGCTGSVA_HALLMARK_BILE_ACID_METABOLISMEER5.3115e-040.3155image
chr12:71702347-71703175:+THCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.0937e-02-0.1142image
ENSG00000139291.12,TMEM19THCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.1152e-02-0.1139image
chr12:71702347-71703175:+THYMGSVA_HALLMARK_ANDROGEN_RESPONSEEER2.0291e-040.3370image
ENSG00000139291.12,TMEM19THYMGSVA_HALLMARK_ANDROGEN_RESPONSEEAG2.0291e-040.3370image
ENSG00000139291.12,TMEM19UCECGSVA_HALLMARK_HEME_METABOLISMEAG2.6369e-040.2838image
chr12:71702347-71703175:+UCECGSVA_HALLMARK_HEME_METABOLISMEER2.6369e-040.2838image
ENSG00000139291.12,TMEM19UCSGSVA_HALLMARK_PROTEIN_SECRETIONEAG7.7149e-030.3725image
chr12:71702347-71703175:+UCSGSVA_HALLMARK_PROTEIN_SECRETIONEER7.7149e-030.3725image
ENSG00000139291.12,TMEM19UVMGSVA_HALLMARK_UV_RESPONSE_UPEAG8.9297e-05-0.4666image
chr12:71702347-71703175:+UVMGSVA_HALLMARK_UV_RESPONSE_UPEER8.9297e-05-0.4666image


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7. Enriched editing regions and drugs for TMEM19


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000139291.12,TMEM19ACCEHT.1864EAG2.0463e-02-0.2827image
chr12:71702347-71703175:+ACCBAY.61.3606EER9.9977e-03-0.3126image
chr12:71702347-71703175:+BLCAAxitinibEER2.6144e-05-0.2150image
ENSG00000139291.12,TMEM19BLCAAxitinibEAG2.6409e-05-0.2149image
ENSG00000139291.12,TMEM19BRCAJNK.Inhibitor.VIIIEAG3.1201e-060.1430image
chr12:71702347-71703175:+BRCAJNK.Inhibitor.VIIIEER3.1185e-060.1430image
chr12:71702347-71703175:+CESCBAY.61.3606EER1.1976e-06-0.2779image
ENSG00000139291.12,TMEM19CESCBAY.61.3606EAG1.2447e-06-0.2774image
chr12:71702347-71703175:+CHOLJNJ.26854165EER4.1658e-020.3462image
ENSG00000139291.12,TMEM19CHOLJNJ.26854165EAG4.1658e-020.3462image
chr12:71702347-71703175:+COADABT.888EER3.2895e-020.1329image
ENSG00000139291.12,TMEM19COADABT.888EAG3.2151e-020.1334image
chr12:71702347-71703175:+DLBCImatinibEER2.0518e-02-0.3336image
ENSG00000139291.12,TMEM19DLBCImatinibEAG2.0518e-02-0.3336image
chr12:71702347-71703175:+ESCAMethotrexateEER1.0944e-030.2550image
ENSG00000139291.12,TMEM19ESCAMethotrexateEAG1.0821e-030.2553image
chr12:71702347-71703175:+GBMBAY.61.3606EER1.4156e-02-0.1907image
ENSG00000139291.12,TMEM19GBMBAY.61.3606EAG1.4156e-02-0.1907image
chr12:71702347-71703175:+HNSCCGP.60474EER1.8238e-060.2128image
ENSG00000139291.12,TMEM19HNSCCGP.60474EAG1.7734e-060.2130image
chr12:71702347-71703175:+KICHGefitinibEER1.5822e-030.3870image
ENSG00000139291.12,TMEM19KICHGefitinibEAG1.5822e-030.3870image
chr12:71702347-71703175:+KIRCFH535EER1.6576e-05-0.2190image
ENSG00000139291.12,TMEM19KIRCFH535EAG1.7159e-05-0.2186image
chr12:71702347-71703175:+KIRPCEP.701EER2.9694e-070.2990image
ENSG00000139291.12,TMEM19KIRPCEP.701EAG3.2576e-070.2980image
chr12:71702347-71703175:+LGGMG.132EER5.3072e-130.3083image
ENSG00000139291.12,TMEM19LGGMG.132EAG4.6394e-130.3090image
chr12:71702347-71703175:+LIHCElesclomolEER7.1634e-030.1469image
ENSG00000139291.12,TMEM19LIHCElesclomolEAG7.8309e-030.1453image
chr12:71702347-71703175:+LUADGDC0941EER5.9085e-03-0.1244image
ENSG00000139291.12,TMEM19LUADGDC0941EAG5.7475e-03-0.1249image
chr12:71702347-71703175:+LUSCCamptothecinEER4.6077e-050.1845image
ENSG00000139291.12,TMEM19LUSCCamptothecinEAG4.6077e-050.1845image
ENSG00000139291.12,TMEM19MESOCyclopamineEAG1.3807e-020.2726image
chr12:71702347-71703175:+MESOCyclopamineEER1.3807e-020.2726image
chr12:71702347-71703175:+OVBIBW2992EER3.2391e-03-0.1720image
ENSG00000139291.12,TMEM19OVBIBW2992EAG3.3675e-03-0.1713image
chr12:71702347-71703175:+PAADAKT.inhibitor.VIIIEER5.8343e-04-0.2626image
ENSG00000139291.12,TMEM19PAADAKT.inhibitor.VIIIEAG5.8343e-04-0.2626image
chr12:71702347-71703175:+PCPGCamptothecinEER5.0340e-050.2974image
ENSG00000139291.12,TMEM19PCPGCamptothecinEAG5.2661e-050.2966image
ENSG00000139291.12,TMEM19PRADBAY.61.3606EAG6.5051e-05-0.1936image
chr12:71702347-71703175:+PRADBAY.61.3606EER6.4696e-05-0.1937image
chr12:71702347-71703175:+READCyclopamineEER2.7488e-020.2337image
ENSG00000139291.12,TMEM19READCyclopamineEAG2.7488e-020.2337image
ENSG00000139291.12,TMEM19SARCBMS.536924EAG2.9426e-050.2615image
chr12:71702347-71703175:+SARCBMS.536924EER2.9244e-050.2615image
chr12:71702347-71703175:+SKCMCI.1040EER8.5271e-050.1858image
ENSG00000139291.12,TMEM19SKCMCI.1040EAG8.5385e-050.1858image
ENSG00000139291.12,TMEM19STADATRAEAG2.6924e-030.1571image
chr12:71702347-71703175:+STADATRAEER2.7539e-030.1567image
chr12:71702347-71703175:+TGCTCyclopamineEER4.4287e-040.3197image
ENSG00000139291.12,TMEM19TGCTCyclopamineEAG4.4287e-040.3197image
chr12:71702347-71703175:+THCAGDC.0449EER1.6353e-030.1411image
ENSG00000139291.12,TMEM19THCAGDC.0449EAG1.6576e-030.1409image
ENSG00000139291.12,TMEM19THYMAZD6482EAG7.4296e-05-0.3579image
chr12:71702347-71703175:+THYMAZD6482EER7.4296e-05-0.3579image
ENSG00000139291.12,TMEM19UCECBicalutamideEAG7.5030e-07-0.3783image
chr12:71702347-71703175:+UCECBicalutamideEER7.5030e-07-0.3783image
chr12:71702347-71703175:+UCSBMS.509744EER3.3231e-020.3017image
ENSG00000139291.12,TMEM19UCSBMS.509744EAG3.3231e-020.3017image
chr12:71702347-71703175:+UVMJNJ.26854165EER5.3113e-050.4795image
ENSG00000139291.12,TMEM19UVMJNJ.26854165EAG5.3113e-050.4795image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType