CAeditome Logo

Home

Download

Statistics

Landscape

Help

Contact
Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ELP2 (ImmuneEditome ID:55250)

1. Gene summary of enriched editing regions for ELP2

check button Gene summary
Gene informationGene symbol

ELP2

Gene ID

55250

GeneSynonymsMRT58|SHINC-2|STATIP1|StIP
GeneCytomap

18q12.2

GeneTypeprotein-coding
GeneDescriptionelongator complex protein 2|STAT3-interacting protein 1|elongation protein 2 homolog|elongator protein 2|signal transducer and activator of transcription 3 interacting protein 1
GeneModificationdate20230329
UniprotIDQ6IA86;F5GWY6;H0YFW0;K7ER35;F5GYE9;F5GX79
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr18:36165662-36166624:+ENST00000350494.9ENSG00000134759.12ELP2intronicAluSx,AluSz,AluSqchr18:36165662-36166624:+.alignment
chr18:36165662-36166624:+ENST00000351393.9ENSG00000134759.12ELP2intronicAluSx,AluSz,AluSqchr18:36165662-36166624:+.alignment
chr18:36165662-36166624:+ENST00000358232.9ENSG00000134759.12ELP2intronicAluSx,AluSz,AluSqchr18:36165662-36166624:+.alignment
chr18:36165662-36166624:+ENST00000423854.5ENSG00000134759.12ELP2intronicAluSx,AluSz,AluSqchr18:36165662-36166624:+.alignment
chr18:36165662-36166624:+ENST00000442325.5ENSG00000134759.12ELP2intronicAluSx,AluSz,AluSqchr18:36165662-36166624:+.alignment
chr18:36165662-36166624:+ENST00000539560.4ENSG00000134759.12ELP2intronicAluSx,AluSz,AluSqchr18:36165662-36166624:+.alignment
chr18:36165662-36166624:+ENST00000540766.4ENSG00000134759.12ELP2intronicAluSx,AluSz,AluSqchr18:36165662-36166624:+.alignment
chr18:36165662-36166624:+ENST00000542824.4ENSG00000134759.12ELP2intronicAluSx,AluSz,AluSqchr18:36165662-36166624:+.alignment
chr18:36171809-36172160:+ENST00000536830.1ENSG00000134759.12ELP2ncRNA_intronicAluJb,AluJrchr18:36171809-36172160:+.alignment
chr18:36171809-36172160:+ENST00000541748.4ENSG00000134759.12ELP2ncRNA_intronicAluJb,AluJrchr18:36171809-36172160:+.alignment
chr18:36171809-36172160:+ENST00000544274.1ENSG00000134759.12ELP2ncRNA_intronicAluJb,AluJrchr18:36171809-36172160:+.alignment
chr18:36171809-36172160:+ENST00000545302.4ENSG00000134759.12ELP2ncRNA_intronicAluJb,AluJrchr18:36171809-36172160:+.alignment
chr18:36174787-36174962:+ENST00000358232.9ENSG00000134759.12ELP2UTR3AluSxchr18:36174787-36174962:+.alignment
chr18:36174787-36174962:+ENST00000540766.4ENSG00000134759.12ELP2UTR3AluSxchr18:36174787-36174962:+.alignment
chr18:36178651-36179428:+ENST00000358232.9ENSG00000134759.12ELP2UTR3AluSx1,FLAM_A,L1MC5chr18:36178651-36179428:+.alignment


Top

2. Tumor-specific enriched editing regions for ELP2


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
ENSG00000134759.12,ELP2KIRCEAG7.5474e-08image


Top

check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr18:36174787-36174962:+ESCAPathEER3.6508e-027.5483e-030.3534image


Top

check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

Top

3. Enriched editing regions and immune related genes for ELP2


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



Top

4. Enriched editing regions and immune related splicing for ELP2


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



Top

5. Enriched editing regions and immune infiltration for ELP2


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000134759.12,ELP2BLCAEAGT_cells_regulatory_(Tregs)3.4945e-020.2799image
chr18:36165662-36166624:+BRCAEERMacrophages_M11.9341e-020.1253image
chr18:36178651-36179428:+BRCAEERT_cells_regulatory_(Tregs)3.6137e-040.1915image
ENSG00000134759.12,ELP2BRCAEAGT_cells_regulatory_(Tregs)9.2401e-050.1648image
ENSG00000134759.12,ELP2CESCEAGB_cells_memory1.4000e-030.4938image
ENSG00000134759.12,ELP2COADEAGEosinophils4.1729e-030.4062image
chr18:36165662-36166624:+ESCAEERPlasma_cells3.8081e-02-0.3520image
chr18:36174787-36174962:+ESCAEERT_cells_gamma_delta5.8993e-030.3379image
ENSG00000134759.12,ELP2ESCAEAGT_cells_CD4_memory_activated3.1996e-040.3651image
chr18:36165662-36166624:+GBMEERT_cells_regulatory_(Tregs)1.8088e-030.6265image
ENSG00000134759.12,ELP2GBMEAGNeutrophils2.1245e-030.4092image
ENSG00000134759.12,ELP2HNSCEAGB_cells_naive1.4946e-02-0.2747image
chr18:36165662-36166624:+KIRCEERNK_cells_activated2.8993e-020.2920image
ENSG00000134759.12,ELP2KIRCEAGMonocytes1.1826e-02-0.2130image
chr18:36165662-36166624:+LAMLEERNeutrophils3.2705e-020.3519image
ENSG00000134759.12,ELP2LAMLEAGT_cells_CD4_memory_activated2.2028e-030.4115image
chr18:36165662-36166624:+LUADEERDendritic_cells_resting2.3723e-020.4340image
chr18:36178651-36179428:+LUADEERNK_cells_activated3.6415e-020.4384image
ENSG00000134759.12,ELP2LUADEAGNK_cells_activated2.8054e-040.3444image
ENSG00000134759.12,ELP2LUSCEAGT_cells_follicular_helper3.8946e-020.2058image
chr18:36165662-36166624:+OVEERNeutrophils1.0721e-020.3768image
ENSG00000134759.12,ELP2PAADEAGMacrophages_M02.0456e-020.3903image
ENSG00000134759.12,ELP2SKCMEAGT_cells_CD4_memory_resting4.1556e-02-0.2177image
chr18:36165662-36166624:+STADEERDendritic_cells_resting1.0011e-030.4280image
chr18:36178651-36179428:+STADEERT_cells_regulatory_(Tregs)1.4138e-02-0.3291image
ENSG00000134759.12,ELP2STADEAGNK_cells_activated4.7415e-020.1555image
ENSG00000134759.12,ELP2THCAEAGMacrophages_M01.3106e-020.2763image
ENSG00000134759.12,ELP2UCECEAGT_cells_gamma_delta1.4818e-030.5810image


Top

6. Enriched editing regions and immune gene sets for ELP2


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


Top

check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000134759.12,ELP2COADEAG6.6172e-04-0.47425.4815e-03-0.39488.7825e-04-0.46463.8934e-02-0.2991image


Top

check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000134759.12,ELP2BLCAGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG1.7599e-05-0.5356image
chr18:36178651-36179428:+BRCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.9380e-030.1668image
chr18:36165662-36166624:+BRCAGSVA_HALLMARK_GLYCOLYSISEER1.9818e-030.1652image
ENSG00000134759.12,ELP2BRCAGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG2.0599e-04-0.1565image
ENSG00000134759.12,ELP2CESCGSVA_HALLMARK_PROTEIN_SECRETIONEAG8.3150e-05-0.5879image
ENSG00000134759.12,ELP2COADGSVA_HALLMARK_SPERMATOGENESISEAG5.8504e-05-0.5465image
chr18:36165662-36166624:+ESCAGSVA_HALLMARK_MYOGENESISEER1.6346e-02-0.4031image
ENSG00000134759.12,ELP2ESCAGSVA_HALLMARK_APICAL_JUNCTIONEAG3.9046e-04-0.3602image
chr18:36174787-36174962:+ESCAGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEER2.6883e-030.3663image
ENSG00000134759.12,ELP2GBMGSVA_HALLMARK_PEROXISOMEEAG5.2365e-03-0.3748image
ENSG00000134759.12,ELP2HNSCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG3.2212e-03-0.3295image
ENSG00000134759.12,ELP2KIRCGSVA_HALLMARK_MITOTIC_SPINDLEEAG6.8908e-07-0.4064image
ENSG00000134759.12,ELP2KIRPGSVA_HALLMARK_SPERMATOGENESISEAG1.7240e-02-0.3040image
ENSG00000134759.12,ELP2LAMLGSVA_HALLMARK_MYC_TARGETS_V2EAG2.1538e-03-0.4124image
chr18:36165662-36166624:+LAMLGSVA_HALLMARK_PANCREAS_BETA_CELLSEER4.4246e-020.3327image
ENSG00000134759.12,ELP2LGGGSVA_HALLMARK_MYC_TARGETS_V2EAG1.1460e-030.1914image
ENSG00000134759.12,ELP2LUADGSVA_HALLMARK_HEME_METABOLISMEAG4.0153e-04-0.3361image
chr18:36165662-36166624:+LUSCGSVA_HALLMARK_IL2_STAT5_SIGNALINGEER7.2275e-030.4235image
ENSG00000134759.12,ELP2LUSCGSVA_HALLMARK_PROTEIN_SECRETIONEAG8.4093e-03-0.2609image
chr18:36178651-36179428:+OVGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER3.0950e-03-0.4794image
ENSG00000134759.12,ELP2OVGSVA_HALLMARK_E2F_TARGETSEAG1.2204e-020.2523image
chr18:36165662-36166624:+OVGSVA_HALLMARK_GLYCOLYSISEER4.8241e-040.4992image
ENSG00000134759.12,ELP2PAADGSVA_HALLMARK_BILE_ACID_METABOLISMEAG9.6211e-03-0.4316image
ENSG00000134759.12,ELP2PRADGSVA_HALLMARK_UV_RESPONSE_DNEAG5.6930e-04-0.2678image
ENSG00000134759.12,ELP2SARCGSVA_HALLMARK_UV_RESPONSE_DNEAG2.0594e-03-0.3811image
ENSG00000134759.12,ELP2SKCMGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.1489e-02-0.2683image
ENSG00000134759.12,ELP2STADGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.5291e-04-0.2716image
chr18:36178651-36179428:+STADGSVA_HALLMARK_APICAL_SURFACEEER1.1813e-020.3372image
chr18:36165662-36166624:+STADGSVA_HALLMARK_FATTY_ACID_METABOLISMEER6.2917e-040.4430image
ENSG00000134759.12,ELP2THCAGSVA_HALLMARK_UV_RESPONSE_DNEAG5.9698e-03-0.3048image
ENSG00000134759.12,ELP2UCECGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.9106e-02-0.4480image
ENSG00000134759.12,ELP2UCSGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG1.9470e-03-0.6232image


Top

7. Enriched editing regions and drugs for ELP2


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000134759.12,ELP2BLCAEmbelinEAG1.3861e-020.3243image
chr18:36178651-36179428:+BRCABMS.708163EER4.4066e-050.2187image
ENSG00000134759.12,ELP2BRCAMidostaurinEAG4.9691e-050.1709image
chr18:36165662-36166624:+BRCAA.770041EER1.4078e-04-0.2027image
ENSG00000134759.12,ELP2CESCBI.2536EAG1.3253e-02-0.3933image
ENSG00000134759.12,ELP2COADGSK.650394EAG1.1192e-050.5878image
chr18:36174787-36174962:+ESCABIRB.0796EER7.4705e-030.3289image
chr18:36165662-36166624:+ESCAImatinibEER1.9395e-020.3934image
ENSG00000134759.12,ELP2ESCAErlotinibEAG5.1260e-030.2880image
ENSG00000134759.12,ELP2GBMBosutinibEAG1.4441e-02-0.3312image
ENSG00000134759.12,ELP2HNSCJW.7.52.1EAG2.2054e-02-0.2590image
ENSG00000134759.12,ELP2KIRCBMS.708163EAG7.5607e-040.2824image
chr18:36165662-36166624:+KIRCMetforminEER1.5136e-04-0.4851image
ENSG00000134759.12,ELP2KIRPFH535EAG7.6764e-030.3382image
ENSG00000134759.12,ELP2LAMLCytarabineEAG2.4027e-020.3097image
ENSG00000134759.12,ELP2LGGGW843682XEAG7.1189e-05-0.2327image
ENSG00000134759.12,ELP2LIHCIPA.3EAG2.3242e-02-0.3828image
ENSG00000134759.12,ELP2LUADDMOGEAG5.0422e-030.2692image
chr18:36165662-36166624:+LUADBMS.754807EER2.1922e-02-0.4392image
chr18:36178651-36179428:+LUADBleomycinEER3.7249e-02-0.4366image
ENSG00000134759.12,ELP2LUSCIPA.3EAG6.4473e-03-0.2694image
chr18:36165662-36166624:+LUSCGemcitabineEER2.9889e-02-0.3481image
chr18:36165662-36166624:+OVA.443654EER4.2070e-02-0.3044image
ENSG00000134759.12,ELP2OVEHT.1864EAG1.2694e-02-0.2509image
chr18:36178651-36179428:+OVEmbelinEER1.2913e-020.4104image
ENSG00000134759.12,ELP2PRADMetforminEAG1.9432e-03-0.2417image
ENSG00000134759.12,ELP2SARCEmbelinEAG5.2822e-040.4243image
ENSG00000134759.12,ELP2SKCMGDC0941EAG2.7277e-030.3175image
chr18:36178651-36179428:+STADBIRB.0796EER2.2849e-020.3065image
ENSG00000134759.12,ELP2STADGW.441756EAG5.4129e-03-0.2169image
ENSG00000134759.12,ELP2THCABAY.61.3606EAG5.9609e-050.4333image
ENSG00000134759.12,ELP2UCECImatinibEAG3.8917e-030.5368image
ENSG00000134759.12,ELP2UCSBIRB.0796EAG3.9406e-03-0.5888image


Top

check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType