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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: C2orf42 (ImmuneEditome ID:54980)

1. Gene summary of enriched editing regions for C2orf42

check button Gene summary
Gene informationGene symbol

C2orf42

Gene ID

54980

GeneSynonyms-
GeneCytomap

2p13.3

GeneTypeprotein-coding
GeneDescriptionuncharacterized protein C2orf42
GeneModificationdate20230329
UniprotIDQ9NWW7;C9JJF4;C9JKD5;C9JV10;C9J5U1;C9JS43;C9J4L7;C9JZF3;C9JK51
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr2:70217271-70224240:-ENST00000470096.1ENSG00000115998.6C2orf42ncRNA_intronicFLAM_C,AluSx3,AluJr,MERX,AluJb,L2a,AluSg,A-rich,MLT1C,AluY,AluSx1,L1MB7chr2:70217271-70224240:-.alignment
chr2:70232720-70233707:-ENST00000470096.1ENSG00000115998.6C2orf42ncRNA_intronicFLAM_C,AluSx,AluSgchr2:70232720-70233707:-.alignment
chr2:70237241-70239075:-ENST00000470096.1ENSG00000115998.6C2orf42ncRNA_intronicAluSz,(T)n,AluSx3,AluSx,AluJo,AluYchr2:70237241-70239075:-.alignment
chr2:70245116-70246262:-ENST00000470096.1ENSG00000115998.6C2orf42ncRNA_intronicAluSx,L1MC5,AluSzchr2:70245116-70246262:-.alignment


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2. Tumor-specific enriched editing regions for C2orf42


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr2:70237241-70239075:-STADPathEER6.0471e-033.7655e-020.1900image
chr2:70245116-70246262:-STADPathEER1.6579e-034.5454e-030.4562image
ENSG00000115998.6,C2orf42UCECCliEAG7.4775e-083.7498e-020.4565image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr2:70237241-70239075:-STADEER2.0428e-023.2061e-028.4624e+01image

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3. Enriched editing regions and immune related genes for C2orf42


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr2:70217271-70224240:-ESCAEERENSG00000157168,NRG10.27833.0876e-024.5607e-110.5122imageNDDX54;DGCR8;EIF4A3;FBL;FUS;HNRNPA2B1;HNRNPM;IGF2BP2;NOP58;PTBP1;SRSF9;TAF15;TARBP2;TARDBP;U2AF2;UPF1;DKC1;HNRNPC;HNRNPK;SRSF1;ELAVL1NRG1T_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr2:70217271-70224240:-ESCAEERENSG00000229526,KRT16P40.25124.3567e-026.2923e-080.4309imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_P53_PATHWAY
chr2:70217271-70224240:-LAMLEERENSG00000105085,MED260.35452.9205e-029.1507e-110.5067imageTIA1DDX42;DDX54;DGCR8;EIF4A3;FAM120A;FBL;FTO;FUS;HNRNPA1;HNRNPA2B1;HNRNPM;HNRNPUL1;IGF2BP2;KHDRBS1;LIN28;LIN28B;LSM11;NOP58;NUMA1;PTBP1;SAFB2;SLTM;SRSF9;TAF15;TARBP2;TARDBP;TRA2A;U2AF2;UPF1;XRN2;DKC1;EIF4G2;HNRNPC;HNRNPK;SF3A3;SRSF1;TIA1;ELAVL1NAB_cells_naiveGSVA_HALLMARK_KRAS_SIGNALING_DN
chr2:70217271-70224240:-LAMLEERENSG00000174871,CNIH20.34423.5814e-023.7049e-100.4922imageTIA1DDX54;DGCR8;EIF4A3;FAM120A;FBL;FUS;HNRNPA2B1;HNRNPUL1;IGF2BP2;LIN28;LSM11;NOP58;NUMA1;PTBP1;SLTM;TAF15;U2AF2;UPF1;XRN2;ZNF184;DKC1;HNRNPK;TIA1;ELAVL1NAB_cells_naiveGSVA_HALLMARK_KRAS_SIGNALING_DN

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4. Enriched editing regions and immune related splicing for C2orf42


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr2:70217271-70224240:-
ESCAEERMEXENSG00000113916.13chr3187734868:187734907:187736089:187736223:187737596:187744525:187745409:187745437-0.33261.9701e-022.8573e-06-0.4032imageTIA1DDX42;DDX54;DGCR8;EIF4A3;FAM120A;FBL;FUS;HNRNPA1;HNRNPA2B1;HNRNPM;HNRNPUL1;IGF2BP2;KHDRBS1;LIN28;LIN28B;LSM11;NOP58;NUMA1;PTBP1;SAFB2;SLTM;SRSF9;TAF15;TARDBP;TRA2A;U2AF2;UPF1;XRN2;ZNF184;DKC1;EIF4G2;HNRNPC;HNRNPK;SF3A3;SRSF1;TIA1;ELAVL1BCL6GSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr2:70217271-70224240:-
ESCAEERIRENSG00000130309.6chr1917579950:17580619:17580698:17580806-0.31244.2567e-029.2049e-07-0.4035imageTIA1DDX42;DDX54;DGCR8;EIF4A3;FAM120A;FBL;FTO;FUS;HNRNPA1;HNRNPA2B1;HNRNPM;HNRNPUL1;IGF2BP2;KHDRBS1;LIN28;LIN28B;LSM11;NOP58;NUMA1;PTBP1;SAFB2;SLTM;SRSF9;TAF15;TARDBP;TRA2A;U2AF2;UPF1;XRN2;ZNF184;DKC1;EIF4G2;HNRNPC;HNRNPK;SF3A3;SRSF1;TIA1;ELAVL1NAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000115998.6,C2orf42
ESCAEAGIRENSG00000129103.13chr756078921:56079151:56079527:56079567-0.22194.8942e-021.8221e-06-0.4406imageNADAR;CELF2;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FBL;FMR1;FUS;HNRNPA1;HNRNPC;HNRNPL;IGF2BP2;IGF2BP3;LIN28A;MBNL2;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;SRSF1;SRSF3;TAF15;TARBP2;TARDBP;TIAL1;TROVE2;U2AF2;UPF1;YTHDF1NAT_cells_CD4_memory_restingGSVA_HALLMARK_HYPOXIA
ENSG00000115998.6,C2orf42
ESCAEAGIRENSG00000128309.12chr2237024191:37024810:37026998:37027053-0.36836.6347e-031.3013e-06-0.4111imageNADAR;CELF2;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G2;ELAVL1;FBL;FMR1;FUS;HNRNPA1;HNRNPC;HNRNPL;IGF2BP2;IGF2BP3;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;SRSF1;SRSF10;SRSF3;TAF15;TARDBP;TIAL1;TROVE2;U2AF2;UPF1;YTHDF1NAT_cells_CD4_memory_restingGSVA_HALLMARK_MTORC1_SIGNALING

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5. Enriched editing regions and immune infiltration for C2orf42


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000115998.6,C2orf42BLCAEAGT_cells_gamma_delta6.2452e-030.4878image
ENSG00000115998.6,C2orf42BRCAEAGT_cells_CD4_memory_resting3.1785e-02-0.1592image
ENSG00000115998.6,C2orf42COADEAGDendritic_cells_activated2.1284e-030.5957image
chr2:70237241-70239075:-ESCAEERT_cells_gamma_delta4.0102e-040.4143image
ENSG00000115998.6,C2orf42ESCAEAGMacrophages_M24.5835e-020.1644image
ENSG00000115998.6,C2orf42KIRPEAGPlasma_cells8.0147e-030.4293image
ENSG00000115998.6,C2orf42LAMLEAGB_cells_naive1.9650e-020.1942image
ENSG00000115998.6,C2orf42LGGEAGMast_cells_activated4.4974e-030.4072image
ENSG00000115998.6,C2orf42LUADEAGT_cells_CD4_memory_resting2.6770e-02-0.2261image
ENSG00000115998.6,C2orf42LUSCEAGT_cells_CD4_memory_activated5.0353e-030.3833image
chr2:70217271-70224240:-OVEERMast_cells_activated7.1105e-040.2380image
chr2:70237241-70239075:-OVEERT_cells_follicular_helper1.5291e-02-0.4891image
ENSG00000115998.6,C2orf42OVEAGMast_cells_activated3.3934e-030.2042image
chr2:70217271-70224240:-STADEEREosinophils1.4724e-020.1523image
chr2:70245116-70246262:-STADEERNK_cells_resting1.7980e-020.3819image
ENSG00000115998.6,C2orf42STADEAGMacrophages_M22.1575e-020.1403image


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6. Enriched editing regions and immune gene sets for C2orf42


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000115998.6,C2orf42BRCAGSVA_HALLMARK_PEROXISOMEEAG1.3606e-030.2357image
chr2:70217271-70224240:-BRCAGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER1.1655e-030.2442image
chr2:70217271-70224240:-ESCAGSVA_HALLMARK_HYPOXIAEER2.1422e-030.2530image
chr2:70237241-70239075:-ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER1.2464e-050.4995image
ENSG00000115998.6,C2orf42ESCAGSVA_HALLMARK_HYPOXIAEAG5.3341e-030.2279image
ENSG00000115998.6,C2orf42KIRCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.6198e-040.4954image
ENSG00000115998.6,C2orf42KIRPGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.4048e-020.4005image
ENSG00000115998.6,C2orf42LAMLGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.9153e-02-0.1950image
ENSG00000115998.6,C2orf42LUADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG3.1335e-050.4114image
ENSG00000115998.6,C2orf42LUSCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG3.0733e-020.3000image
ENSG00000115998.6,C2orf42OVGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.4283e-040.2632image
chr2:70217271-70224240:-OVGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER6.4065e-040.2400image
chr2:70245116-70246262:-STADGSVA_HALLMARK_APOPTOSISEER1.9953e-020.3761image
chr2:70232720-70233707:-STADGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.9038e-020.4123image
ENSG00000115998.6,C2orf42STADGSVA_HALLMARK_APOPTOSISEAG1.8189e-050.2586image
chr2:70217271-70224240:-STADGSVA_HALLMARK_APOPTOSISEER3.9454e-060.2838image
chr2:70237241-70239075:-STADGSVA_HALLMARK_ADIPOGENESISEER1.0971e-030.2898image
ENSG00000115998.6,C2orf42THCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG6.2493e-030.4662image


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7. Enriched editing regions and drugs for C2orf42


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000115998.6,C2orf42BLCACGP.082996EAG2.6167e-02-0.4056image
ENSG00000115998.6,C2orf42BRCAA.770041EAG8.9343e-03-0.1938image
chr2:70217271-70224240:-BRCACCT007093EER1.0185e-020.1943image
ENSG00000115998.6,C2orf42COADAS601245EAG4.3271e-020.4158image
chr2:70217271-70224240:-ESCABexaroteneEER1.6623e-03-0.2589image
chr2:70237241-70239075:-ESCAGSK269962AEER2.4002e-05-0.4851image
ENSG00000115998.6,C2orf42ESCAKIN001.135EAG1.5112e-03-0.2585image
ENSG00000115998.6,C2orf42KIRCJNK.Inhibitor.VIIIEAG1.0987e-030.4361image
chr2:70217271-70224240:-LAMLCCT007093EER2.0470e-020.1930image
ENSG00000115998.6,C2orf42LAMLA.443654EAG3.0487e-02-0.1804image
ENSG00000115998.6,C2orf42LGGABT.888EAG3.7677e-020.3041image
ENSG00000115998.6,C2orf42LUADLenalidomideEAG1.3323e-030.3229image
ENSG00000115998.6,C2orf42LUSCJNK.9LEAG1.2500e-02-0.3441image
ENSG00000115998.6,C2orf42OVMG.132EAG2.8415e-05-0.2893image
chr2:70217271-70224240:-OVMG.132EER5.9623e-05-0.2813image
chr2:70237241-70239075:-OVAZD.2281EER2.2325e-020.4642image
ENSG00000115998.6,C2orf42PRADA.770041EAG1.7147e-03-0.6417image
chr2:70245116-70246262:-STADBMS.708163EER1.9047e-04-0.5694image
chr2:70232720-70233707:-STADGW843682XEER2.3127e-020.4005image
ENSG00000115998.6,C2orf42STADBortezomibEAG2.4002e-03-0.1847image
chr2:70217271-70224240:-STADKU.55933EER1.0573e-02-0.1595image
ENSG00000115998.6,C2orf42THCAGNF.2EAG3.1636e-02-0.3748image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType