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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: PGPEP1 (ImmuneEditome ID:54858)

1. Gene summary of enriched editing regions for PGPEP1

check button Gene summary
Gene informationGene symbol

PGPEP1

Gene ID

54858

GeneSynonymsPAP-I|PGI|PGP|PGP-I|PGPI|Pcp
GeneCytomap

19p13.11

GeneTypeprotein-coding
GeneDescriptionpyroglutamyl-peptidase 1|5-oxoprolyl-peptidase|pGlu-peptidase I|pyroglutamyl aminopeptidase I|pyrrolidone-carboxylate peptidase
GeneModificationdate20230329
UniprotIDM0QX66;Q9NXJ5;M0R0B6;U3KQ24;U3KQG9;S4R2Y9
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr19:18345026-18345957:+ENST00000252813.5ENSG00000130517.12PGPEP1intronicAluJr,AluSz,AluSq2chr19:18345026-18345957:+.alignment
chr19:18345026-18345957:+ENST00000269919.9ENSG00000130517.12PGPEP1intronicAluJr,AluSz,AluSq2chr19:18345026-18345957:+.alignment
chr19:18345026-18345957:+ENST00000595066.4ENSG00000130517.12PGPEP1intronicAluJr,AluSz,AluSq2chr19:18345026-18345957:+.alignment
chr19:18345026-18345957:+ENST00000596962.4ENSG00000130517.12PGPEP1intronicAluJr,AluSz,AluSq2chr19:18345026-18345957:+.alignment
chr19:18345026-18345957:+ENST00000597431.2ENSG00000130517.12PGPEP1intronicAluJr,AluSz,AluSq2chr19:18345026-18345957:+.alignment
chr19:18345026-18345957:+ENST00000600283.5ENSG00000130517.12PGPEP1intronicAluJr,AluSz,AluSq2chr19:18345026-18345957:+.alignment
chr19:18345026-18345957:+ENST00000604499.5ENSG00000130517.12PGPEP1intronicAluJr,AluSz,AluSq2chr19:18345026-18345957:+.alignment
chr19:18353132-18353497:+ENST00000252813.5ENSG00000130517.12PGPEP1intronicAluSq2,AluJbchr19:18353132-18353497:+.alignment
chr19:18353132-18353497:+ENST00000269919.9ENSG00000130517.12PGPEP1intronicAluSq2,AluJbchr19:18353132-18353497:+.alignment
chr19:18353132-18353497:+ENST00000595066.4ENSG00000130517.12PGPEP1intronicAluSq2,AluJbchr19:18353132-18353497:+.alignment
chr19:18353132-18353497:+ENST00000596962.4ENSG00000130517.12PGPEP1intronicAluSq2,AluJbchr19:18353132-18353497:+.alignment
chr19:18353132-18353497:+ENST00000597431.2ENSG00000130517.12PGPEP1intronicAluSq2,AluJbchr19:18353132-18353497:+.alignment
chr19:18353132-18353497:+ENST00000600283.5ENSG00000130517.12PGPEP1intronicAluSq2,AluJbchr19:18353132-18353497:+.alignment
chr19:18353132-18353497:+ENST00000604499.5ENSG00000130517.12PGPEP1intronicAluSq2,AluJbchr19:18353132-18353497:+.alignment
chr19:18358312-18360980:+ENST00000252813.5ENSG00000130517.12PGPEP1intronicAluJo,AluSz,MLT1C,L2b,AluSp,AluSx1chr19:18358312-18360980:+.alignment
chr19:18358312-18360980:+ENST00000269919.9ENSG00000130517.12PGPEP1intronicAluJo,AluSz,MLT1C,L2b,AluSp,AluSx1chr19:18358312-18360980:+.alignment
chr19:18358312-18360980:+ENST00000595552.2ENSG00000130517.12PGPEP1intronicAluJo,AluSz,MLT1C,L2b,AluSp,AluSx1chr19:18358312-18360980:+.alignment
chr19:18358312-18360980:+ENST00000596962.4ENSG00000130517.12PGPEP1intronicAluJo,AluSz,MLT1C,L2b,AluSp,AluSx1chr19:18358312-18360980:+.alignment
chr19:18358312-18360980:+ENST00000597431.2ENSG00000130517.12PGPEP1intronicAluJo,AluSz,MLT1C,L2b,AluSp,AluSx1chr19:18358312-18360980:+.alignment
chr19:18358312-18360980:+ENST00000597663.2ENSG00000130517.12PGPEP1intronicAluJo,AluSz,MLT1C,L2b,AluSp,AluSx1chr19:18358312-18360980:+.alignment
chr19:18358312-18360980:+ENST00000600283.5ENSG00000130517.12PGPEP1intronicAluJo,AluSz,MLT1C,L2b,AluSp,AluSx1chr19:18358312-18360980:+.alignment
chr19:18358312-18360980:+ENST00000604499.5ENSG00000130517.12PGPEP1intronicAluJo,AluSz,MLT1C,L2b,AluSp,AluSx1chr19:18358312-18360980:+.alignment
chr19:18361436-18363208:+ENST00000252813.5ENSG00000130517.12PGPEP1intronicL1ME3G,AluJb,AluJo,L1ME4b,AluSz,AluSq2,(TG)n,AluSx1chr19:18361436-18363208:+.alignment
chr19:18361436-18363208:+ENST00000269919.9ENSG00000130517.12PGPEP1intronicL1ME3G,AluJb,AluJo,L1ME4b,AluSz,AluSq2,(TG)n,AluSx1chr19:18361436-18363208:+.alignment
chr19:18361436-18363208:+ENST00000595552.2ENSG00000130517.12PGPEP1intronicL1ME3G,AluJb,AluJo,L1ME4b,AluSz,AluSq2,(TG)n,AluSx1chr19:18361436-18363208:+.alignment
chr19:18361436-18363208:+ENST00000596962.4ENSG00000130517.12PGPEP1intronicL1ME3G,AluJb,AluJo,L1ME4b,AluSz,AluSq2,(TG)n,AluSx1chr19:18361436-18363208:+.alignment
chr19:18361436-18363208:+ENST00000597431.2ENSG00000130517.12PGPEP1intronicL1ME3G,AluJb,AluJo,L1ME4b,AluSz,AluSq2,(TG)n,AluSx1chr19:18361436-18363208:+.alignment
chr19:18361436-18363208:+ENST00000597663.2ENSG00000130517.12PGPEP1intronicL1ME3G,AluJb,AluJo,L1ME4b,AluSz,AluSq2,(TG)n,AluSx1chr19:18361436-18363208:+.alignment
chr19:18361436-18363208:+ENST00000600283.5ENSG00000130517.12PGPEP1intronicL1ME3G,AluJb,AluJo,L1ME4b,AluSz,AluSq2,(TG)n,AluSx1chr19:18361436-18363208:+.alignment
chr19:18361436-18363208:+ENST00000604499.5ENSG00000130517.12PGPEP1intronicL1ME3G,AluJb,AluJo,L1ME4b,AluSz,AluSq2,(TG)n,AluSx1chr19:18361436-18363208:+.alignment
chr19:18364309-18368468:+ENST00000252813.5ENSG00000130517.12PGPEP1UTR3AluSx1,G-rich,AluSz6,AluJo,AluJbchr19:18364309-18368468:+.alignment
chr19:18364309-18368468:+ENST00000269919.9ENSG00000130517.12PGPEP1UTR3AluSx1,G-rich,AluSz6,AluJo,AluJbchr19:18364309-18368468:+.alignment


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2. Tumor-specific enriched editing regions for PGPEP1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr19:18364309-18368468:+BRCAEER3.1658e-12image
ENSG00000130517.12,PGPEP1BRCAEAG2.4591e-12image
chr19:18364309-18368468:+COADEER6.7905e-18image
ENSG00000130517.12,PGPEP1COADEAG2.4543e-18image
chr19:18364309-18368468:+HNSCEER1.8415e-03image
ENSG00000130517.12,PGPEP1HNSCEAG1.8770e-03image
chr19:18364309-18368468:+KIRCEER1.3359e-04image
ENSG00000130517.12,PGPEP1KIRCEAG7.8476e-05image
chr19:18364309-18368468:+LIHCEER3.4464e-03image
ENSG00000130517.12,PGPEP1LIHCEAG5.0685e-03image
chr19:18364309-18368468:+LUSCEER1.7781e-06image
ENSG00000130517.12,PGPEP1LUSCEAG1.8387e-06image
chr19:18364309-18368468:+PRADEER1.8134e-03image
ENSG00000130517.12,PGPEP1PRADEAG1.4389e-03image
chr19:18364309-18368468:+UCECEER3.6498e-04image
ENSG00000130517.12,PGPEP1UCECEAG2.8146e-04image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr19:18364309-18368468:+BLCAPathEER1.9138e-026.3086e-030.1514image
ENSG00000130517.12,PGPEP1BLCAPathEAG4.3167e-021.2384e-020.1386image
chr19:18364309-18368468:+KIRCPathEER2.8550e-043.7049e-050.1785image
ENSG00000130517.12,PGPEP1KIRCPathEAG6.1395e-047.4000e-050.1713image
chr19:18364309-18368468:+KIRPPathEER3.2819e-024.8164e-020.1231image
chr19:18361436-18363208:+OVCliEER2.0691e-022.0691e-020.4276image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr19:18364309-18368468:+COADEER9.3835e-032.5120e-021.9099e+01image
ENSG00000130517.12,PGPEP1COADEAG9.3835e-032.5604e-021.8955e+01image

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3. Enriched editing regions and immune related genes for PGPEP1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr19:18364309-18368468:+STADEERENSG00000232187,FTH1P70.28031.3984e-052.9962e-180.4341imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr19:18364309-18368468:+STADEERENSG00000213293,CTD-2666L21.30.26454.5535e-052.5459e-170.4230imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
chr19:18364309-18368468:+STADEERENSG00000253676,TAGLN2P10.24641.8539e-041.7648e-170.4249imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HEDGEHOG_SIGNALING
chr19:18364309-18368468:+STADEERENSG00000239246,RP11-464D20.20.19993.5515e-038.6019e-160.4039imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
chr19:18364309-18368468:+DLBCEERENSG00000230829,CTD-2186M15.10.61984.4016e-025.1342e-030.4565imageNNNAGSVA_HALLMARK_PANCREAS_BETA_CELLS
chr19:18364309-18368468:+DLBCEERENSG00000063601,MTMR1-0.61774.9504e-021.7657e-03-0.5030imageNFUS;EIF4A3;ELAVL1;NOP58NAMacrophages_M2GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr19:18364309-18368468:+ESCAEERENSG00000130517,PGPEP1-0.62145.7140e-117.5828e-11-0.5026imageNFUS;EIF4A3;ELAVL1;NOP58NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
chr19:18364309-18368468:+ESCAEERENSG00000163251,FZD5-0.58872.5080e-091.4069e-10-0.4963imageNFUS;EIF4A3;ELAVL1;NOP58FZD5B_cells_naiveGSVA_HALLMARK_BILE_ACID_METABOLISM
chr19:18364309-18368468:+ESCAEERENSG00000229155,RP11-528A4.2-0.55745.8024e-092.5521e-07-0.4085imageNNNAPlasma_cellsGSVA_HALLMARK_BILE_ACID_METABOLISM
chr19:18364309-18368468:+ESCAEERENSG00000126522,ASL-0.56319.1820e-096.0253e-10-0.4811imageNFUS;EIF4A3;NOP58NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
chr19:18364309-18368468:+STADEERENSG00000232187,FTH1P70.28031.3984e-052.9962e-180.4341imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr19:18364309-18368468:+STADEERENSG00000213293,CTD-2666L21.30.26454.5535e-052.5459e-170.4230imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
chr19:18364309-18368468:+STADEERENSG00000253676,TAGLN2P10.24641.8539e-041.7648e-170.4249imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HEDGEHOG_SIGNALING
chr19:18364309-18368468:+STADEERENSG00000239246,RP11-464D20.20.19993.5515e-038.6019e-160.4039imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
chr19:18364309-18368468:+DLBCEERENSG00000230829,CTD-2186M15.10.61984.4016e-025.1342e-030.4565imageNNNAGSVA_HALLMARK_PANCREAS_BETA_CELLS
chr19:18364309-18368468:+DLBCEERENSG00000063601,MTMR1-0.61774.9504e-021.7657e-03-0.5030imageNFUS;EIF4A3;ELAVL1;NOP58NAMacrophages_M2GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr19:18364309-18368468:+ESCAEERENSG00000130517,PGPEP1-0.62145.7140e-117.5828e-11-0.5026imageNFUS;EIF4A3;ELAVL1;NOP58NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
chr19:18364309-18368468:+ESCAEERENSG00000163251,FZD5-0.58872.5080e-091.4069e-10-0.4963imageNFUS;EIF4A3;ELAVL1;NOP58FZD5B_cells_naiveGSVA_HALLMARK_BILE_ACID_METABOLISM
chr19:18364309-18368468:+ESCAEERENSG00000229155,RP11-528A4.2-0.55745.8024e-092.5521e-07-0.4085imageNNNAPlasma_cellsGSVA_HALLMARK_BILE_ACID_METABOLISM
chr19:18364309-18368468:+ESCAEERENSG00000126522,ASL-0.56319.1820e-096.0253e-10-0.4811imageNFUS;EIF4A3;NOP58NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM

More results



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4. Enriched editing regions and immune related splicing for PGPEP1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr19:18364309-18368468:+
ESCAEERA3ENSG00000136153.15chr1375834298:75834387:75835232:75835339:75835151:75835339-0.46391.8938e-049.7794e-10-0.4759imageNFUS;EIF4A3;ELAVL1;NOP58LMO7T_cells_CD4_memory_restingGSVA_HALLMARK_KRAS_SIGNALING_DN
chr19:18364309-18368468:+
ESCAEERIRENSG00000099917.13chr2220568980:20575232:20582610:20582747-0.40972.9321e-032.9654e-08-0.4363imageNFUS;EIF4A3;ELAVL1;NOP58NAT_cells_CD4_memory_restingGSVA_HALLMARK_MTORC1_SIGNALING
chr19:18364309-18368468:+
ESCAEERIRENSG00000140274.9chr1545114320:45115856:45116123:451162580.30861.2940e-023.9358e-080.5050imageNELAVL1NAB_cells_naiveGSVA_HALLMARK_BILE_ACID_METABOLISM
ENSG00000130517.12,PGPEP1
ESCAEAGESENSG00000072518.16chr1163904785:63905043:63906087:63906114:63908876:639089310.40062.1265e-041.6482e-090.5315imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM22;RBM27;RBM47;SBDS;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184MARK2T_cells_CD4_memory_restingGSVA_HALLMARK_PANCREAS_BETA_CELLS
ENSG00000130517.12,PGPEP1
ESCAEAGIRENSG00000026508.12chr1135205714:35206243:35208104:35208164-0.43884.1229e-043.0338e-07-0.4074imageNACIN1;ADAR;CNBP;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;HNRNPA1;HNRNPC;HNRNPL;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;LIN28A;LIN28B;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;PTBP1;RBFOX2;RBM27;RBM47;SAFB2;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF2;UPF1;YTHDC1;YTHDF1;YWHAG;ZNF184CD44T_cells_CD4_memory_restingGSVA_HALLMARK_KRAS_SIGNALING_DN
chr19:18364309-18368468:+
ESCAEERMEXENSG00000026508.12chr1135190009:35190065:35198108:35198246:35206114:35206243:35208104:35208164-0.44781.8938e-044.8538e-10-0.4864imageNFUS;EIF4A3;ELAVL1;NOP58CD44T_cells_CD4_memory_restingGSVA_HALLMARK_KRAS_SIGNALING_DN
ENSG00000130517.12,PGPEP1
ESCAEAGMEXENSG00000196776.10chr3108047080:108047292:108049618:108049710:108050577:108051970:108057476:108057569-0.42771.0171e-036.1989e-09-0.4551imageNACIN1;ADAR;AIFM1;AUH;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM22;RBM27;RBM47;SAFB2;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZNF184CD47T_cells_regulatory_(Tregs)GSVA_HALLMARK_APICAL_SURFACE
ENSG00000130517.12,PGPEP1
ESCAEAGMEXENSG00000182541.13chr2231212294:31212424:31225719:31225823:31248384:31248769:31258290:31258426-0.49523.2798e-051.0063e-13-0.5625imageNACIN1;ADAR;AIFM1;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM22;RBM27;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_KRAS_SIGNALING_DN
chr19:18364309-18368468:+
ESCAEERA5ENSG00000198561.8chr1157816296:57816717:57815393:57815500:57815393:578160010.46408.4457e-051.6393e-110.5175imageNFUS;EIF4A3;ELAVL1;NOP58CTNND1T_cells_regulatory_(Tregs)GSVA_HALLMARK_KRAS_SIGNALING_DN
chr19:18364309-18368468:+
ESCAEERA5ENSG00000104067.12chr1529718892:29719138:29720357:29720708:29719776:297207080.37396.6360e-031.3656e-090.4722imageNFUS;EIF4A3;ELAVL1;NOP58NAT_cells_CD4_memory_restingGSVA_HALLMARK_BILE_ACID_METABOLISM

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5. Enriched editing regions and immune infiltration for PGPEP1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr19:18364309-18368468:+ACCEERPlasma_cells4.6391e-020.2308image
ENSG00000130517.12,PGPEP1ACCEAGPlasma_cells4.5993e-020.2312image
chr19:18364309-18368468:+BLCAEERMacrophages_M12.2266e-050.2332image
ENSG00000130517.12,PGPEP1BLCAEAGT_cells_regulatory_(Tregs)9.3061e-05-0.2151image
chr19:18361436-18363208:+BRCAEERT_cells_CD4_memory_activated2.4563e-030.5495image
chr19:18364309-18368468:+BRCAEERMast_cells_resting2.8240e-03-0.0933image
ENSG00000130517.12,PGPEP1BRCAEAGT_cells_CD4_memory_activated3.3390e-030.0917image
chr19:18364309-18368468:+CESCEERB_cells_naive2.9336e-03-0.2083image
ENSG00000130517.12,PGPEP1CESCEAGB_cells_naive2.0606e-03-0.2151image
chr19:18364309-18368468:+CHOLEERNK_cells_resting2.8739e-02-0.3809image
ENSG00000130517.12,PGPEP1CHOLEAGNK_cells_resting2.8739e-02-0.3809image
chr19:18364309-18368468:+COADEERDendritic_cells_resting2.4171e-02-0.1374image
ENSG00000130517.12,PGPEP1COADEAGMast_cells_activated5.7097e-040.2083image
chr19:18364309-18368468:+DLBCEERMacrophages_M22.4582e-020.3741image
ENSG00000130517.12,PGPEP1DLBCEAGMacrophages_M22.4582e-020.3741image
chr19:18345026-18345957:+ESCAEERT_cells_regulatory_(Tregs)2.3273e-02-0.4926image
chr19:18358312-18360980:+ESCAEERT_cells_CD4_memory_activated2.1417e-020.3583image
chr19:18364309-18368468:+ESCAEERT_cells_regulatory_(Tregs)3.3849e-04-0.2907image
ENSG00000130517.12,PGPEP1ESCAEAGT_cells_regulatory_(Tregs)2.7369e-04-0.2949image
chr19:18361436-18363208:+KIRCEERMonocytes1.1270e-020.4422image
chr19:18364309-18368468:+KIRCEERMacrophages_M21.3890e-04-0.1937image
ENSG00000130517.12,PGPEP1KIRCEAGPlasma_cells2.3800e-040.1867image
chr19:18361436-18363208:+KIRPEEREosinophils2.5518e-070.8618image
chr19:18364309-18368468:+KIRPEERT_cells_CD4_memory_activated3.3042e-040.2112image
ENSG00000130517.12,PGPEP1KIRPEAGT_cells_CD4_memory_activated5.2606e-040.2041image
chr19:18364309-18368468:+LAMLEERT_cells_follicular_helper1.2382e-030.2648image
ENSG00000130517.12,PGPEP1LAMLEAGMast_cells_resting6.5090e-030.2235image
chr19:18364309-18368468:+LGGEERT_cells_CD4_naive1.2165e-050.1893image
ENSG00000130517.12,PGPEP1LGGEAGT_cells_CD4_naive1.2196e-050.1893image
chr19:18364309-18368468:+LIHCEERT_cells_regulatory_(Tregs)2.4797e-03-0.1584image
ENSG00000130517.12,PGPEP1LIHCEAGDendritic_cells_resting8.1148e-03-0.1388image
chr19:18364309-18368468:+LUADEERT_cells_CD4_memory_activated1.6409e-040.1728image
ENSG00000130517.12,PGPEP1LUADEAGT_cells_CD4_memory_activated1.6694e-040.1726image
chr19:18364309-18368468:+LUSCEERMast_cells_resting6.4447e-03-0.1367image
ENSG00000130517.12,PGPEP1LUSCEAGMast_cells_resting6.5369e-03-0.1364image
chr19:18364309-18368468:+MESOEERMast_cells_activated3.4097e-020.2574image
ENSG00000130517.12,PGPEP1MESOEAGMast_cells_activated3.4097e-020.2574image
chr19:18345026-18345957:+OVEERDendritic_cells_resting3.4534e-02-0.4008image
chr19:18361436-18363208:+OVEERT_cells_regulatory_(Tregs)2.4216e-020.4898image
chr19:18364309-18368468:+OVEERMacrophages_M11.5872e-040.2235image
ENSG00000130517.12,PGPEP1OVEAGMacrophages_M12.8495e-040.2149image
chr19:18364309-18368468:+PAADEERMast_cells_activated1.4823e-020.1845image
ENSG00000130517.12,PGPEP1PAADEAGMast_cells_activated1.4849e-020.1844image
chr19:18364309-18368468:+PRADEERMacrophages_M28.4838e-040.1496image
ENSG00000130517.12,PGPEP1PRADEAGMacrophages_M21.3411e-030.1439image
chr19:18364309-18368468:+SARCEERMacrophages_M07.9978e-040.2168image
ENSG00000130517.12,PGPEP1SARCEAGMacrophages_M07.9968e-040.2168image
chr19:18364309-18368468:+SKCMEERT_cells_CD83.7853e-060.2160image
ENSG00000130517.12,PGPEP1SKCMEAGT_cells_CD83.7846e-060.2160image
chr19:18358312-18360980:+STADEERB_cells_memory8.8172e-03-0.2391image
chr19:18364309-18368468:+STADEERT_cells_CD84.3325e-030.1488image
ENSG00000130517.12,PGPEP1STADEAGMacrophages_M14.1899e-030.1494image
chr19:18364309-18368468:+THCAEERNK_cells_resting7.1546e-030.1200image
ENSG00000130517.12,PGPEP1THCAEAGNK_cells_resting1.1072e-020.1134image
chr19:18364309-18368468:+THYMEERNK_cells_activated1.1798e-020.2461image
ENSG00000130517.12,PGPEP1THYMEAGNK_cells_activated2.8164e-020.2143image
ENSG00000130517.12,PGPEP1UCECEAGMacrophages_M03.7528e-02-0.1636image
chr19:18364309-18368468:+UCSEERMacrophages_M01.2720e-020.3433image
ENSG00000130517.12,PGPEP1UCSEAGMacrophages_M01.2720e-020.3433image
chr19:18364309-18368468:+UVMEERMonocytes1.2978e-020.2802image
ENSG00000130517.12,PGPEP1UVMEAGMonocytes1.2978e-020.2802image


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6. Enriched editing regions and immune gene sets for PGPEP1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr19:18364309-18368468:+BLCAEER6.2777e-04image1.2206e-070.2887image
ENSG00000130517.12,PGPEP1BLCAEAG1.0266e-03image2.9943e-060.2558image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr19:18364309-18368468:+BLCAEER3.4196e-040.19784.9387e-020.10931.1689e-040.21243.0794e-070.2798image
ENSG00000130517.12,PGPEP1BRCAEAG1.5670e-150.24571.4654e-090.18761.4724e-040.11844.9767e-030.0878image
chr19:18364309-18368468:+BRCAEER8.6486e-160.24809.9659e-100.18961.0118e-040.12134.8020e-030.0882image
ENSG00000130517.12,PGPEP1HNSCEAG1.1226e-020.17344.0955e-02-0.14026.3690e-030.18643.9294e-020.1414image
chr19:18364309-18368468:+HNSCEER1.1173e-020.17363.9561e-02-0.14126.4021e-030.18634.1373e-020.1399image
ENSG00000130517.12,PGPEP1LUADEAG8.1140e-050.18061.6378e-040.17281.8107e-040.17174.5044e-040.1610image
chr19:18364309-18368468:+LUADEER7.8958e-050.18091.5923e-040.17311.7252e-040.17224.1868e-040.1619image
ENSG00000130517.12,PGPEP1SARCEAG1.1181e-030.21098.8133e-030.17024.9036e-040.22522.8370e-060.2994image
chr19:18364309-18368468:+SARCEER1.1183e-030.21098.8151e-030.17024.9043e-040.22522.8370e-060.2994image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr19:18364309-18368468:+BLCAGSVA_HALLMARK_APICAL_JUNCTIONEER1.9064e-080.3059image
ENSG00000130517.12,PGPEP1BLCAGSVA_HALLMARK_APICAL_JUNCTIONEAG1.4181e-060.2638image
chr19:18361436-18363208:+BRCAGSVA_HALLMARK_HYPOXIAEER3.8207e-020.3937image
chr19:18364309-18368468:+BRCAGSVA_HALLMARK_MYC_TARGETS_V2EER5.8895e-120.2131image
ENSG00000130517.12,PGPEP1BRCAGSVA_HALLMARK_MYC_TARGETS_V2EAG1.1233e-110.2102image
chr19:18364309-18368468:+CESCGSVA_HALLMARK_P53_PATHWAYEER9.3049e-060.3063image
ENSG00000130517.12,PGPEP1CESCGSVA_HALLMARK_P53_PATHWAYEAG7.1571e-060.3092image
chr19:18364309-18368468:+CHOLGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.7036e-020.4126image
ENSG00000130517.12,PGPEP1CHOLGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.7036e-020.4126image
chr19:18364309-18368468:+COADGSVA_HALLMARK_BILE_ACID_METABOLISMEER6.1745e-05-0.2418image
ENSG00000130517.12,PGPEP1COADGSVA_HALLMARK_BILE_ACID_METABOLISMEAG6.4913e-08-0.3216image
ENSG00000130517.12,PGPEP1DLBCGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG4.4976e-030.4626image
chr19:18364309-18368468:+DLBCGSVA_HALLMARK_PANCREAS_BETA_CELLSEER4.4976e-030.4626image
chr19:18364309-18368468:+ESCAGSVA_HALLMARK_HYPOXIAEER1.1338e-050.3522image
ENSG00000130517.12,PGPEP1ESCAGSVA_HALLMARK_HYPOXIAEAG1.0285e-050.3538image
chr19:18358312-18360980:+ESCAGSVA_HALLMARK_ADIPOGENESISEER1.1627e-02-0.3904image
chr19:18364309-18368468:+GBMGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER5.3772e-06-0.3448image
ENSG00000130517.12,PGPEP1GBMGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG5.4243e-06-0.3447image
chr19:18364309-18368468:+HNSCGSVA_HALLMARK_HYPOXIAEER4.1373e-020.1399image
ENSG00000130517.12,PGPEP1HNSCGSVA_HALLMARK_HYPOXIAEAG3.9294e-020.1414image
ENSG00000130517.12,PGPEP1KICHGSVA_HALLMARK_PROTEIN_SECRETIONEAG7.1250e-03-0.3385image
chr19:18364309-18368468:+KICHGSVA_HALLMARK_PROTEIN_SECRETIONEER7.1250e-03-0.3385image
chr19:18364309-18368468:+KIRCGSVA_HALLMARK_MITOTIC_SPINDLEEER2.2941e-06-0.2390image
ENSG00000130517.12,PGPEP1KIRCGSVA_HALLMARK_MITOTIC_SPINDLEEAG7.5078e-07-0.2496image
chr19:18361436-18363208:+KIRPGSVA_HALLMARK_E2F_TARGETSEER1.4538e-02-0.5134image
chr19:18364309-18368468:+KIRPGSVA_HALLMARK_MITOTIC_SPINDLEEER6.6066e-07-0.2895image
ENSG00000130517.12,PGPEP1KIRPGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.1223e-07-0.2945image
ENSG00000130517.12,PGPEP1LGGGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.2664e-22-0.4086image
chr19:18364309-18368468:+LGGGSVA_HALLMARK_MITOTIC_SPINDLEEER1.2681e-22-0.4086image
ENSG00000130517.12,PGPEP1LIHCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.2346e-020.1312image
chr19:18364309-18368468:+LIHCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER4.9785e-030.1471image
ENSG00000130517.12,PGPEP1LUADGSVA_HALLMARK_MYC_TARGETS_V1EAG2.1956e-090.2712image
chr19:18364309-18368468:+LUADGSVA_HALLMARK_MYC_TARGETS_V1EER2.1094e-090.2715image
chr19:18364309-18368468:+LUSCGSVA_HALLMARK_MYC_TARGETS_V1EER8.8023e-040.1665image
ENSG00000130517.12,PGPEP1LUSCGSVA_HALLMARK_MYC_TARGETS_V1EAG8.5510e-040.1669image
chr19:18364309-18368468:+MESOGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER1.7644e-02-0.2870image
ENSG00000130517.12,PGPEP1MESOGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG1.7644e-02-0.2870image
chr19:18361436-18363208:+OVGSVA_HALLMARK_APICAL_SURFACEEER1.1479e-020.5402image
ENSG00000130517.12,PGPEP1OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.6357e-090.3499image
chr19:18358312-18360980:+OVGSVA_HALLMARK_ANGIOGENESISEER2.7832e-02-0.3022image
chr19:18364309-18368468:+OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.1493e-090.3530image
chr19:18345026-18345957:+OVGSVA_HALLMARK_MYC_TARGETS_V2EER6.8549e-030.4991image
ENSG00000130517.12,PGPEP1PAADGSVA_HALLMARK_BILE_ACID_METABOLISMEAG3.8310e-03-0.2181image
chr19:18364309-18368468:+PAADGSVA_HALLMARK_BILE_ACID_METABOLISMEER3.8336e-03-0.2181image
ENSG00000130517.12,PGPEP1PCPGGSVA_HALLMARK_MITOTIC_SPINDLEEAG8.0082e-03-0.1999image
chr19:18364309-18368468:+PCPGGSVA_HALLMARK_MITOTIC_SPINDLEEER7.9514e-03-0.2000image
ENSG00000130517.12,PGPEP1PRADGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG6.9816e-08-0.2396image
chr19:18364309-18368468:+PRADGSVA_HALLMARK_DNA_REPAIREER9.2076e-080.2375image
ENSG00000130517.12,PGPEP1READGSVA_HALLMARK_BILE_ACID_METABOLISMEAG6.7447e-05-0.3992image
chr19:18364309-18368468:+READGSVA_HALLMARK_BILE_ACID_METABOLISMEER5.4423e-05-0.4038image
ENSG00000130517.12,PGPEP1SARCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG4.4247e-080.3470image
chr19:18364309-18368468:+SARCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER4.4272e-080.3470image
chr19:18364309-18368468:+SKCMGSVA_HALLMARK_UV_RESPONSE_DNEER1.9531e-05-0.1998image
ENSG00000130517.12,PGPEP1SKCMGSVA_HALLMARK_UV_RESPONSE_DNEAG1.9689e-05-0.1997image
chr19:18358312-18360980:+STADGSVA_HALLMARK_UV_RESPONSE_UPEER1.3585e-020.2257image
chr19:18345026-18345957:+STADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.8374e-040.4758image
chr19:18361436-18363208:+STADGSVA_HALLMARK_MITOTIC_SPINDLEEER2.2279e-02-0.2637image
ENSG00000130517.12,PGPEP1STADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.8837e-040.1940image
chr19:18364309-18368468:+STADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER5.7027e-050.2088image
chr19:18364309-18368468:+THCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER3.8409e-050.1828image
ENSG00000130517.12,PGPEP1THCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG5.6562e-050.1789image
ENSG00000130517.12,PGPEP1THYMGSVA_HALLMARK_HEME_METABOLISMEAG1.5774e-03-0.3047image
chr19:18364309-18368468:+THYMGSVA_HALLMARK_MITOTIC_SPINDLEEER1.0381e-02-0.2503image
ENSG00000130517.12,PGPEP1UCECGSVA_HALLMARK_NOTCH_SIGNALINGEAG7.5166e-03-0.2093image
chr19:18364309-18368468:+UCECGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.9223e-02-0.1855image
chr19:18364309-18368468:+UCSGSVA_HALLMARK_DNA_REPAIREER1.3375e-020.3410image
ENSG00000130517.12,PGPEP1UCSGSVA_HALLMARK_DNA_REPAIREAG1.3375e-020.3410image
ENSG00000130517.12,PGPEP1UVMGSVA_HALLMARK_MYC_TARGETS_V2EAG2.5332e-030.3372image
chr19:18364309-18368468:+UVMGSVA_HALLMARK_MYC_TARGETS_V2EER2.5332e-030.3372image


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7. Enriched editing regions and drugs for PGPEP1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000130517.12,PGPEP1ACCMethotrexateEAG4.4982e-03-0.3246image
chr19:18364309-18368468:+ACCMethotrexateEER4.4883e-03-0.3246image
chr19:18364309-18368468:+BLCAKU.55933EER2.1060e-10-0.3435image
ENSG00000130517.12,PGPEP1BLCAKU.55933EAG1.3578e-09-0.3281image
chr19:18361436-18363208:+BRCAAKT.inhibitor.VIIIEER4.6257e-040.6176image
chr19:18364309-18368468:+BRCACCT007093EER5.9265e-120.2130image
ENSG00000130517.12,PGPEP1BRCACCT007093EAG1.2569e-110.2097image
chr19:18364309-18368468:+CESCCGP.082996EER4.1848e-07-0.3471image
ENSG00000130517.12,PGPEP1CESCCGP.082996EAG3.2965e-07-0.3492image
ENSG00000130517.12,PGPEP1CHOLKIN001.135EAG3.6075e-05-0.6544image
chr19:18364309-18368468:+CHOLKIN001.135EER3.6075e-05-0.6544image
ENSG00000130517.12,PGPEP1COADAG.014699EAG9.0533e-05-0.2360image
chr19:18364309-18368468:+COADKU.55933EER1.2370e-04-0.2319image
chr19:18364309-18368468:+DLBCGefitinibEER4.0784e-030.4671image
ENSG00000130517.12,PGPEP1DLBCGefitinibEAG4.0784e-030.4671image
chr19:18364309-18368468:+ESCAJNJ.26854165EER1.9705e-11-0.5173image
ENSG00000130517.12,PGPEP1ESCAJNJ.26854165EAG2.5656e-11-0.5147image
chr19:18361436-18363208:+ESCABMS.536924EER3.0376e-02-0.4520image
chr19:18358312-18360980:+ESCAGefitinibEER3.0028e-02-0.3392image
chr19:18345026-18345957:+ESCAEpothilone.BEER1.3148e-020.5315image
chr19:18364309-18368468:+GBMFH535EER1.2731e-040.2930image
ENSG00000130517.12,PGPEP1GBMFH535EAG1.3192e-040.2924image
chr19:18364309-18368468:+HNSCErlotinibEER1.5601e-06-0.3229image
ENSG00000130517.12,PGPEP1HNSCErlotinibEAG1.9545e-06-0.3200image
ENSG00000130517.12,PGPEP1KICHJNJ.26854165EAG2.2127e-03-0.3816image
chr19:18364309-18368468:+KICHJNJ.26854165EER2.2127e-03-0.3816image
ENSG00000130517.12,PGPEP1KIRCJNK.9LEAG1.6844e-070.2634image
chr19:18361436-18363208:+KIRCCGP.082996EER4.2480e-020.3608image
chr19:18364309-18368468:+KIRCBMS.536924EER7.3132e-07-0.2508image
chr19:18361436-18363208:+KIRPCGP.082996EER6.7280e-03-0.5599image
chr19:18364309-18368468:+KIRPAZD6482EER9.8481e-080.3093image
ENSG00000130517.12,PGPEP1KIRPAZD6482EAG8.4052e-080.3109image
ENSG00000130517.12,PGPEP1LAMLBI.D1870EAG9.5178e-05-0.3163image
chr19:18364309-18368468:+LAMLBI.D1870EER1.0712e-03-0.2680image
ENSG00000130517.12,PGPEP1LGGEHT.1864EAG7.4367e-14-0.3181image
chr19:18364309-18368468:+LGGEHT.1864EER7.4399e-14-0.3181image
chr19:18364309-18368468:+LIHCGSK.650394EER3.3336e-040.1873image
ENSG00000130517.12,PGPEP1LIHCCytarabineEAG3.5663e-040.1864image
ENSG00000130517.12,PGPEP1LUADGemcitabineEAG9.2644e-05-0.1791image
chr19:18364309-18368468:+LUADGemcitabineEER9.1524e-05-0.1793image
ENSG00000130517.12,PGPEP1LUSCBI.D1870EAG8.5995e-05-0.1960image
chr19:18364309-18368468:+LUSCBI.D1870EER8.7638e-05-0.1958image
chr19:18361436-18363208:+OVAZD8055EER2.6083e-020.4843image
chr19:18345026-18345957:+OVBIRB.0796EER1.7031e-02-0.4472image
chr19:18364309-18368468:+OVImatinibEER7.6459e-090.3360image
chr19:18358312-18360980:+OVBI.D1870EER1.6801e-02-0.3271image
ENSG00000130517.12,PGPEP1OVCEP.701EAG3.0759e-09-0.3443image
ENSG00000130517.12,PGPEP1PAADBleomycinEAG9.5981e-040.2482image
chr19:18364309-18368468:+PAADBleomycinEER9.5712e-040.2482image
ENSG00000130517.12,PGPEP1PCPGAZD6482EAG7.1981e-040.2533image
chr19:18364309-18368468:+PCPGAZD6482EER7.1693e-040.2534image
chr19:18364309-18368468:+PRADEmbelinEER1.3948e-060.2151image
ENSG00000130517.12,PGPEP1PRADEmbelinEAG5.9511e-070.2224image
ENSG00000130517.12,PGPEP1READCGP.082996EAG7.4510e-05-0.3970image
chr19:18364309-18368468:+READCGP.082996EER1.1691e-04-0.3869image
ENSG00000130517.12,PGPEP1SARCEHT.1864EAG6.4784e-080.3429image
chr19:18364309-18368468:+SARCEHT.1864EER6.4802e-080.3429image
chr19:18364309-18368468:+SKCMJW.7.52.1EER3.3454e-06-0.2171image
ENSG00000130517.12,PGPEP1SKCMJW.7.52.1EAG3.3887e-06-0.2170image
chr19:18345026-18345957:+STADBIRB.0796EER2.2260e-020.3024image
chr19:18361436-18363208:+STADCMKEER3.5545e-070.5482image
ENSG00000130517.12,PGPEP1STADJNJ.26854165EAG5.9270e-05-0.2086image
chr19:18364309-18368468:+STADJNJ.26854165EER2.4358e-04-0.1909image
chr19:18358312-18360980:+STADAICAREER2.7659e-020.2019image
ENSG00000130517.12,PGPEP1THCAEmbelinEAG1.5303e-120.3090image
chr19:18364309-18368468:+THCACCT007093EER1.4290e-100.2814image
ENSG00000130517.12,PGPEP1THYMDMOGEAG3.1265e-060.4371image
chr19:18364309-18368468:+THYMDMOGEER1.8437e-030.3019image
ENSG00000130517.12,PGPEP1UCECFH535EAG7.4087e-060.3440image
chr19:18364309-18368468:+UCECFH535EER3.0251e-040.2829image
chr19:18364309-18368468:+UCSAICAREER1.9437e-020.3232image
ENSG00000130517.12,PGPEP1UCSAICAREAG1.9437e-020.3232image
ENSG00000130517.12,PGPEP1UVMCCT007093EAG3.6222e-050.4497image
chr19:18364309-18368468:+UVMCCT007093EER3.6222e-050.4497image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType