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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ESRP1 (ImmuneEditome ID:54845)

1. Gene summary of enriched editing regions for ESRP1

check button Gene summary
Gene informationGene symbol

ESRP1

Gene ID

54845

GeneSynonymsDFNB109|RBM35A|RMB35A
GeneCytomap

8q22.1

GeneTypeprotein-coding
GeneDescriptionepithelial splicing regulatory protein 1|RNA-binding motif protein 35A|RNA-binding protein 35A
GeneModificationdate20230329
UniprotIDQ6NXG1;H0YBB3;A0A2U3TZN9
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr8:94654645-94655884:+ENST00000358397.8ENSG00000104413.14ESRP1intronic(GT)n,AluSz,(T)n,AluJrchr8:94654645-94655884:+.alignment
chr8:94654645-94655884:+ENST00000423620.5ENSG00000104413.14ESRP1intronic(GT)n,AluSz,(T)n,AluJrchr8:94654645-94655884:+.alignment
chr8:94654645-94655884:+ENST00000433389.5ENSG00000104413.14ESRP1intronic(GT)n,AluSz,(T)n,AluJrchr8:94654645-94655884:+.alignment
chr8:94654645-94655884:+ENST00000454170.5ENSG00000104413.14ESRP1intronic(GT)n,AluSz,(T)n,AluJrchr8:94654645-94655884:+.alignment
chr8:94654645-94655884:+ENST00000517610.1ENSG00000104413.14ESRP1intronic(GT)n,AluSz,(T)n,AluJrchr8:94654645-94655884:+.alignment
chr8:94654645-94655884:+ENST00000519505.4ENSG00000104413.14ESRP1intronic(GT)n,AluSz,(T)n,AluJrchr8:94654645-94655884:+.alignment
chr8:94654645-94655884:+ENST00000520385.1ENSG00000104413.14ESRP1intronic(GT)n,AluSz,(T)n,AluJrchr8:94654645-94655884:+.alignment
chr8:94654645-94655884:+ENST00000522756.4ENSG00000104413.14ESRP1intronic(GT)n,AluSz,(T)n,AluJrchr8:94654645-94655884:+.alignment
chr8:94660338-94660666:+ENST00000358397.8ENSG00000104413.14ESRP1intronicAluSx,AluSzchr8:94660338-94660666:+.alignment
chr8:94660338-94660666:+ENST00000423620.5ENSG00000104413.14ESRP1intronicAluSx,AluSzchr8:94660338-94660666:+.alignment
chr8:94660338-94660666:+ENST00000433389.5ENSG00000104413.14ESRP1intronicAluSx,AluSzchr8:94660338-94660666:+.alignment
chr8:94660338-94660666:+ENST00000454170.5ENSG00000104413.14ESRP1intronicAluSx,AluSzchr8:94660338-94660666:+.alignment
chr8:94660338-94660666:+ENST00000517610.1ENSG00000104413.14ESRP1intronicAluSx,AluSzchr8:94660338-94660666:+.alignment
chr8:94660338-94660666:+ENST00000519505.4ENSG00000104413.14ESRP1intronicAluSx,AluSzchr8:94660338-94660666:+.alignment
chr8:94660338-94660666:+ENST00000520385.1ENSG00000104413.14ESRP1intronicAluSx,AluSzchr8:94660338-94660666:+.alignment
chr8:94660338-94660666:+ENST00000522756.4ENSG00000104413.14ESRP1intronicAluSx,AluSzchr8:94660338-94660666:+.alignment
chr8:94668844-94669808:+ENST00000358397.8ENSG00000104413.14ESRP1intronicAluSx,AluSx1chr8:94668844-94669808:+.alignment
chr8:94668844-94669808:+ENST00000423620.5ENSG00000104413.14ESRP1intronicAluSx,AluSx1chr8:94668844-94669808:+.alignment
chr8:94668844-94669808:+ENST00000433389.5ENSG00000104413.14ESRP1intronicAluSx,AluSx1chr8:94668844-94669808:+.alignment
chr8:94668844-94669808:+ENST00000454170.5ENSG00000104413.14ESRP1intronicAluSx,AluSx1chr8:94668844-94669808:+.alignment
chr8:94668844-94669808:+ENST00000517610.1ENSG00000104413.14ESRP1intronicAluSx,AluSx1chr8:94668844-94669808:+.alignment
chr8:94668844-94669808:+ENST00000519505.4ENSG00000104413.14ESRP1intronicAluSx,AluSx1chr8:94668844-94669808:+.alignment
chr8:94676070-94676952:+ENST00000358397.8ENSG00000104413.14ESRP1intronicAluSx,(TG)n,AluSc8chr8:94676070-94676952:+.alignment
chr8:94676070-94676952:+ENST00000423620.5ENSG00000104413.14ESRP1intronicAluSx,(TG)n,AluSc8chr8:94676070-94676952:+.alignment
chr8:94676070-94676952:+ENST00000433389.5ENSG00000104413.14ESRP1intronicAluSx,(TG)n,AluSc8chr8:94676070-94676952:+.alignment
chr8:94676070-94676952:+ENST00000454170.5ENSG00000104413.14ESRP1intronicAluSx,(TG)n,AluSc8chr8:94676070-94676952:+.alignment
chr8:94676070-94676952:+ENST00000517610.1ENSG00000104413.14ESRP1intronicAluSx,(TG)n,AluSc8chr8:94676070-94676952:+.alignment
chr8:94676070-94676952:+ENST00000519505.4ENSG00000104413.14ESRP1intronicAluSx,(TG)n,AluSc8chr8:94676070-94676952:+.alignment
chr8:94680518-94681891:+ENST00000358397.8ENSG00000104413.14ESRP1intronicAluSp,AluY,AluSz,AluSx4,AluJrchr8:94680518-94681891:+.alignment
chr8:94680518-94681891:+ENST00000423620.5ENSG00000104413.14ESRP1intronicAluSp,AluY,AluSz,AluSx4,AluJrchr8:94680518-94681891:+.alignment
chr8:94680518-94681891:+ENST00000433389.5ENSG00000104413.14ESRP1intronicAluSp,AluY,AluSz,AluSx4,AluJrchr8:94680518-94681891:+.alignment
chr8:94680518-94681891:+ENST00000454170.5ENSG00000104413.14ESRP1intronicAluSp,AluY,AluSz,AluSx4,AluJrchr8:94680518-94681891:+.alignment
chr8:94680518-94681891:+ENST00000517610.1ENSG00000104413.14ESRP1intronicAluSp,AluY,AluSz,AluSx4,AluJrchr8:94680518-94681891:+.alignment
chr8:94680518-94681891:+ENST00000519505.4ENSG00000104413.14ESRP1intronicAluSp,AluY,AluSz,AluSx4,AluJrchr8:94680518-94681891:+.alignment
chr8:94688961-94689179:+ENST00000358397.8ENSG00000104413.14ESRP1intronicL1MB7,AluSz6chr8:94688961-94689179:+.alignment
chr8:94688961-94689179:+ENST00000423620.5ENSG00000104413.14ESRP1intronicL1MB7,AluSz6chr8:94688961-94689179:+.alignment
chr8:94688961-94689179:+ENST00000433389.5ENSG00000104413.14ESRP1intronicL1MB7,AluSz6chr8:94688961-94689179:+.alignment
chr8:94688961-94689179:+ENST00000454170.5ENSG00000104413.14ESRP1intronicL1MB7,AluSz6chr8:94688961-94689179:+.alignment
chr8:94688961-94689179:+ENST00000517610.1ENSG00000104413.14ESRP1intronicL1MB7,AluSz6chr8:94688961-94689179:+.alignment
chr8:94688961-94689179:+ENST00000519505.4ENSG00000104413.14ESRP1intronicL1MB7,AluSz6chr8:94688961-94689179:+.alignment
chr8:94699414-94699638:+ENST00000358397.8ENSG00000104413.14ESRP1intronicAluJbchr8:94699414-94699638:+.alignment
chr8:94699414-94699638:+ENST00000423620.5ENSG00000104413.14ESRP1intronicAluJbchr8:94699414-94699638:+.alignment
chr8:94699414-94699638:+ENST00000433389.5ENSG00000104413.14ESRP1intronicAluJbchr8:94699414-94699638:+.alignment
chr8:94699414-94699638:+ENST00000454170.5ENSG00000104413.14ESRP1intronicAluJbchr8:94699414-94699638:+.alignment
chr8:94699414-94699638:+ENST00000517610.1ENSG00000104413.14ESRP1intronicAluJbchr8:94699414-94699638:+.alignment
chr8:94699414-94699638:+ENST00000519505.4ENSG00000104413.14ESRP1intronicAluJbchr8:94699414-94699638:+.alignment
chr8:94701038-94702731:+ENST00000358397.8ENSG00000104413.14ESRP1intronic(CTTTTT)n,AluJb,AluJo,AluSx,AluYchr8:94701038-94702731:+.alignment
chr8:94701038-94702731:+ENST00000423620.5ENSG00000104413.14ESRP1intronic(CTTTTT)n,AluJb,AluJo,AluSx,AluYchr8:94701038-94702731:+.alignment
chr8:94701038-94702731:+ENST00000433389.5ENSG00000104413.14ESRP1intronic(CTTTTT)n,AluJb,AluJo,AluSx,AluYchr8:94701038-94702731:+.alignment
chr8:94701038-94702731:+ENST00000454170.5ENSG00000104413.14ESRP1intronic(CTTTTT)n,AluJb,AluJo,AluSx,AluYchr8:94701038-94702731:+.alignment
chr8:94701038-94702731:+ENST00000517610.1ENSG00000104413.14ESRP1intronic(CTTTTT)n,AluJb,AluJo,AluSx,AluYchr8:94701038-94702731:+.alignment
chr8:94701038-94702731:+ENST00000519505.4ENSG00000104413.14ESRP1intronic(CTTTTT)n,AluJb,AluJo,AluSx,AluYchr8:94701038-94702731:+.alignment
chr8:94704460-94705437:+ENST00000358397.8ENSG00000104413.14ESRP1intronicMIR,AluSx,AluJrchr8:94704460-94705437:+.alignment
chr8:94704460-94705437:+ENST00000423620.5ENSG00000104413.14ESRP1intronicMIR,AluSx,AluJrchr8:94704460-94705437:+.alignment
chr8:94704460-94705437:+ENST00000433389.5ENSG00000104413.14ESRP1intronicMIR,AluSx,AluJrchr8:94704460-94705437:+.alignment
chr8:94704460-94705437:+ENST00000454170.5ENSG00000104413.14ESRP1intronicMIR,AluSx,AluJrchr8:94704460-94705437:+.alignment
chr8:94704460-94705437:+ENST00000517610.1ENSG00000104413.14ESRP1intronicMIR,AluSx,AluJrchr8:94704460-94705437:+.alignment
chr8:94704460-94705437:+ENST00000519505.4ENSG00000104413.14ESRP1intronicMIR,AluSx,AluJrchr8:94704460-94705437:+.alignment


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2. Tumor-specific enriched editing regions for ESRP1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr8:94676070-94676952:+TGCTPathEER2.3650e-022.8744e-020.3995image
ENSG00000104413.14,ESRP1TGCTCliEAG3.5097e-021.2990e-020.4557image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for ESRP1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for ESRP1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000104413.14,ESRP1
ESCAEAGIRENSG00000182670.9chr2137158130:37158203:37159698:37159745-0.33001.1978e-021.7609e-05-0.4170imageNADAR;CELF2;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DICER1;DKC1;ELAVL1;EWSR1;FBL;FMR1;FUS;FXR2;HNRNPC;HNRNPL;HNRNPM;IGF2BP2;ILF3;LIN28A;METTL3;MOV10;NOP56;NOP58;RBFOX2;TAF15;TARDBP;TROVE2;U2AF2;UPF1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
ENSG00000104413.14,ESRP1
ESCAEAGIRENSG00000204859.7chr16580540:6581299:6582057:6582223-0.44051.4520e-031.0722e-06-0.4141imageNADAR;CELF2;CNBP;CSTF2T;DDX54;DGCR8;DHX9;ELAVL1;FBL;FMR1;FUS;FXR2;HNRNPC;HNRNPL;HNRNPM;IGF2BP2;ILF3;METTL3;MOV10;NOP56;NOP58;RBFOX2;TAF15;TARDBP;TROVE2;U2AF2;UPF1NAT_cells_CD4_memory_restingGSVA_HALLMARK_GLYCOLYSIS

More results



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5. Enriched editing regions and immune infiltration for ESRP1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr8:94676070-94676952:+BLCAEERT_cells_regulatory_(Tregs)1.0797e-020.3191image
ENSG00000104413.14,ESRP1BLCAEAGT_cells_CD4_memory_activated1.6579e-030.3343image
chr8:94676070-94676952:+BRCAEERB_cells_naive2.9957e-02-0.1632image
ENSG00000104413.14,ESRP1BRCAEAGB_cells_naive2.6600e-02-0.1380image
ENSG00000104413.14,ESRP1CESCEAGPlasma_cells3.1072e-020.4236image
chr8:94676070-94676952:+COADEERT_cells_follicular_helper2.5466e-020.4979image
ENSG00000104413.14,ESRP1COADEAGDendritic_cells_activated2.5275e-020.3534image
chr8:94660338-94660666:+ESCAEERT_cells_CD4_memory_activated4.0258e-020.3831image
chr8:94668844-94669808:+ESCAEERT_cells_CD82.2794e-020.2347image
chr8:94704460-94705437:+ESCAEERT_cells_regulatory_(Tregs)4.3047e-02-0.2426image
ENSG00000104413.14,ESRP1ESCAEAGDendritic_cells_resting4.1526e-020.1784image
chr8:94676070-94676952:+LUADEERMast_cells_activated1.8226e-02-0.3065image
chr8:94676070-94676952:+LUSCEERNK_cells_resting1.4145e-020.3007image
chr8:94660338-94660666:+OVEERPlasma_cells6.6360e-060.7134image
chr8:94668844-94669808:+OVEERMast_cells_activated2.6440e-020.2209image
chr8:94676070-94676952:+OVEERMacrophages_M13.7074e-02-0.2592image
chr8:94680518-94681891:+OVEERT_cells_gamma_delta3.0657e-040.5542image
chr8:94704460-94705437:+OVEERT_cells_CD4_memory_resting1.1873e-030.3673image
ENSG00000104413.14,ESRP1OVEAGMacrophages_M26.8089e-030.2246image
ENSG00000104413.14,ESRP1PRADEAGMast_cells_resting9.1085e-03-0.4229image
chr8:94660338-94660666:+STADEERT_cells_regulatory_(Tregs)4.0317e-02-0.2655image
chr8:94676070-94676952:+STADEERT_cells_CD4_memory_activated1.3664e-020.2010image
chr8:94680518-94681891:+STADEERB_cells_naive1.1118e-020.3430image
chr8:94701038-94702731:+STADEERMacrophages_M24.9431e-020.2592image
chr8:94676070-94676952:+TGCTEERB_cells_naive2.5124e-02-0.3046image
ENSG00000104413.14,ESRP1TGCTEAGB_cells_naive7.4736e-03-0.3538image


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6. Enriched editing regions and immune gene sets for ESRP1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000104413.14,ESRP1CESCEAG2.6559e-030.56466.9769e-030.51598.4452e-040.61424.0755e-020.4038image
ENSG00000104413.14,ESRP1STADEAG2.2354e-030.20518.4471e-030.17722.8936e-040.24219.2731e-040.2218image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr8:94676070-94676952:+BLCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER7.5602e-040.4135image
ENSG00000104413.14,ESRP1BLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG2.9171e-050.4345image
chr8:94676070-94676952:+BRCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER4.5676e-040.2607image
ENSG00000104413.14,ESRP1BRCAGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.1402e-060.2975image
ENSG00000104413.14,ESRP1CESCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG1.0292e-030.6062image
ENSG00000104413.14,ESRP1COADGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG3.9097e-030.4461image
chr8:94676070-94676952:+COADGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER2.3794e-020.5030image
chr8:94668844-94669808:+ESCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER4.8484e-020.2041image
chr8:94680518-94681891:+ESCAGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER9.6627e-030.4978image
chr8:94704460-94705437:+ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER6.3458e-060.5105image
ENSG00000104413.14,ESRP1ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG7.1667e-030.2339image
chr8:94676070-94676952:+LUSCGSVA_HALLMARK_NOTCH_SIGNALINGEER2.5295e-02-0.2753image
chr8:94676070-94676952:+OVGSVA_HALLMARK_G2M_CHECKPOINTEER3.9113e-02-0.2566image
chr8:94668844-94669808:+OVGSVA_HALLMARK_MITOTIC_SPINDLEEER7.5317e-04-0.3299image
chr8:94680518-94681891:+OVGSVA_HALLMARK_PROTEIN_SECRETIONEER5.5563e-030.4412image
chr8:94704460-94705437:+OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER9.7372e-050.4347image
ENSG00000104413.14,ESRP1OVGSVA_HALLMARK_BILE_ACID_METABOLISMEAG5.7448e-030.2291image
chr8:94660338-94660666:+OVGSVA_HALLMARK_COAGULATIONEER4.4042e-020.3641image
ENSG00000104413.14,ESRP1PRADGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG1.0364e-040.5947image
ENSG00000104413.14,ESRP1STADGSVA_HALLMARK_ANDROGEN_RESPONSEEAG5.7759e-050.2677image
chr8:94676070-94676952:+STADGSVA_HALLMARK_IL2_STAT5_SIGNALINGEER1.5320e-030.2565image
chr8:94701038-94702731:+STADGSVA_HALLMARK_BILE_ACID_METABOLISMEER4.3057e-03-0.3695image
chr8:94668844-94669808:+STADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER6.9101e-040.2655image
chr8:94680518-94681891:+STADGSVA_HALLMARK_MYC_TARGETS_V2EER3.9455e-02-0.2812image
ENSG00000104413.14,ESRP1TGCTGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG2.3465e-040.4727image
chr8:94676070-94676952:+TGCTGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER1.0347e-030.4343image


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7. Enriched editing regions and drugs for ESRP1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr8:94676070-94676952:+BLCAGefitinibEER2.0017e-02-0.2925image
ENSG00000104413.14,ESRP1BLCAEHT.1864EAG7.5727e-030.2861image
chr8:94676070-94676952:+BRCAAICAREER3.2200e-050.3071image
ENSG00000104413.14,ESRP1BRCAIPA.3EAG1.2033e-040.2371image
ENSG00000104413.14,ESRP1CESCAZD6244EAG6.3937e-030.5206image
ENSG00000104413.14,ESRP1COADGSK.650394EAG2.0861e-030.4724image
chr8:94676070-94676952:+COADBleomycinEER7.8658e-030.5760image
chr8:94676070-94676952:+ESCAImatinibEER2.0976e-02-0.2123image
chr8:94668844-94669808:+ESCAGNF.2EER1.3187e-02-0.2548image
chr8:94680518-94681891:+ESCALenalidomideEER1.8584e-020.4582image
chr8:94704460-94705437:+ESCAImatinibEER3.6932e-04-0.4138image
ENSG00000104413.14,ESRP1ESCAImatinibEAG5.8518e-04-0.2965image
chr8:94660338-94660666:+ESCACCT018159EER6.9634e-03-0.4901image
chr8:94676070-94676952:+LUADBleomycinEER1.9209e-02-0.3041image
ENSG00000104413.14,ESRP1LUSCErlotinibEAG1.6940e-02-0.2600image
chr8:94676070-94676952:+LUSCErlotinibEER2.3886e-02-0.2779image
chr8:94676070-94676952:+OVBosutinibEER4.6356e-02-0.2480image
chr8:94668844-94669808:+OVCI.1040EER4.2680e-04-0.3441image
chr8:94680518-94681891:+OVGDC.0449EER1.0022e-020.4127image
chr8:94704460-94705437:+OVEmbelinEER1.3729e-030.3630image
ENSG00000104413.14,ESRP1OVMG.132EAG4.4119e-02-0.1686image
chr8:94660338-94660666:+OVMG.132EER1.0217e-03-0.5612image
ENSG00000104413.14,ESRP1PRADCisplatinEAG7.1142e-04-0.5315image
ENSG00000104413.14,ESRP1STADFH535EAG2.5325e-02-0.1508image
chr8:94660338-94660666:+STADAZD6244EER1.2927e-02-0.3192image
chr8:94676070-94676952:+STADGemcitabineEER2.8899e-02-0.1784image
chr8:94701038-94702731:+STADABT.263EER1.8561e-020.3083image
chr8:94668844-94669808:+STADDocetaxelEER3.9781e-02-0.1627image
chr8:94680518-94681891:+STADCCT018159EER7.3784e-03-0.3607image
chr8:94704460-94705437:+STADCMKEER1.5354e-03-0.3240image
ENSG00000104413.14,ESRP1TGCTCyclopamineEAG1.1157e-02-0.3368image
chr8:94676070-94676952:+TGCTCEP.701EER1.3252e-02-0.3351image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType