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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ZNF562 (ImmuneEditome ID:54811)

1. Gene summary of enriched editing regions for ZNF562

check button Gene summary
Gene informationGene symbol

ZNF562

Gene ID

54811

GeneSynonyms-
GeneCytomap

19p13.2

GeneTypeprotein-coding
GeneDescriptionzinc finger protein 562
GeneModificationdate20230517
UniprotIDQ6V9R5;K7EN01;K7ENE4;A0A024R7A3;K7EIE6;K7ELE4;K7EQZ2
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr19:9646034-9648747:-ENST00000293648.7ENSG00000171466.8ZNF562UTR3FLAM_A,L1M5,AluSq2,AluSz,AluJo,AluJr,AluSc,AluSpchr19:9646034-9648747:-.alignment
chr19:9650657-9650956:-ENST00000293648.7ENSG00000171466.8ZNF562UTR3AluSp,MLT1Bchr19:9650657-9650956:-.alignment
chr19:9655086-9656959:-ENST00000293648.7ENSG00000171466.8ZNF562exonicAluSx1,SVA_B,AluSc8,AluSc5,AluSz,AluJo,FLAM_Cchr19:9655086-9656959:-.alignment
chr19:9655086-9656959:-ENST00000453372.5ENSG00000171466.8ZNF562exonicAluSx1,SVA_B,AluSc8,AluSc5,AluSz,AluJo,FLAM_Cchr19:9655086-9656959:-.alignment
chr19:9655086-9656959:-ENST00000585688.4ENSG00000171466.8ZNF562exonicAluSx1,SVA_B,AluSc8,AluSc5,AluSz,AluJo,FLAM_Cchr19:9655086-9656959:-.alignment
chr19:9655086-9656959:-ENST00000588653.4ENSG00000171466.8ZNF562exonicAluSx1,SVA_B,AluSc8,AluSc5,AluSz,AluJo,FLAM_Cchr19:9655086-9656959:-.alignment
chr19:9655086-9656959:-ENST00000589542.1ENSG00000171466.8ZNF562exonicAluSx1,SVA_B,AluSc8,AluSc5,AluSz,AluJo,FLAM_Cchr19:9655086-9656959:-.alignment
chr19:9655086-9656959:-ENST00000590155.4ENSG00000171466.8ZNF562exonicAluSx1,SVA_B,AluSc8,AluSc5,AluSz,AluJo,FLAM_Cchr19:9655086-9656959:-.alignment
chr19:9661372-9661993:-ENST00000293648.7ENSG00000171466.8ZNF562intronicAluJb,AluSx3,AluSzchr19:9661372-9661993:-.alignment
chr19:9661372-9661993:-ENST00000453372.5ENSG00000171466.8ZNF562intronicAluJb,AluSx3,AluSzchr19:9661372-9661993:-.alignment
chr19:9661372-9661993:-ENST00000585350.1ENSG00000171466.8ZNF562intronicAluJb,AluSx3,AluSzchr19:9661372-9661993:-.alignment
chr19:9661372-9661993:-ENST00000585688.4ENSG00000171466.8ZNF562intronicAluJb,AluSx3,AluSzchr19:9661372-9661993:-.alignment
chr19:9661372-9661993:-ENST00000587392.4ENSG00000171466.8ZNF562intronicAluJb,AluSx3,AluSzchr19:9661372-9661993:-.alignment
chr19:9661372-9661993:-ENST00000588653.4ENSG00000171466.8ZNF562intronicAluJb,AluSx3,AluSzchr19:9661372-9661993:-.alignment
chr19:9661372-9661993:-ENST00000589542.1ENSG00000171466.8ZNF562intronicAluJb,AluSx3,AluSzchr19:9661372-9661993:-.alignment
chr19:9661372-9661993:-ENST00000590155.4ENSG00000171466.8ZNF562intronicAluJb,AluSx3,AluSzchr19:9661372-9661993:-.alignment
chr19:9663735-9664296:-ENST00000293648.7ENSG00000171466.8ZNF562intronicAluSx,AluSx3,AluSpchr19:9663735-9664296:-.alignment
chr19:9663735-9664296:-ENST00000453372.5ENSG00000171466.8ZNF562intronicAluSx,AluSx3,AluSpchr19:9663735-9664296:-.alignment
chr19:9663735-9664296:-ENST00000585350.1ENSG00000171466.8ZNF562intronicAluSx,AluSx3,AluSpchr19:9663735-9664296:-.alignment
chr19:9663735-9664296:-ENST00000585688.4ENSG00000171466.8ZNF562intronicAluSx,AluSx3,AluSpchr19:9663735-9664296:-.alignment
chr19:9663735-9664296:-ENST00000587392.4ENSG00000171466.8ZNF562intronicAluSx,AluSx3,AluSpchr19:9663735-9664296:-.alignment
chr19:9663735-9664296:-ENST00000588653.4ENSG00000171466.8ZNF562intronicAluSx,AluSx3,AluSpchr19:9663735-9664296:-.alignment
chr19:9663735-9664296:-ENST00000589542.1ENSG00000171466.8ZNF562intronicAluSx,AluSx3,AluSpchr19:9663735-9664296:-.alignment
chr19:9663735-9664296:-ENST00000590155.4ENSG00000171466.8ZNF562intronicAluSx,AluSx3,AluSpchr19:9663735-9664296:-.alignment
chr19:9667795-9668326:-ENST00000293648.7ENSG00000171466.8ZNF562intronicL1MA4,AluJochr19:9667795-9668326:-.alignment
chr19:9667795-9668326:-ENST00000453372.5ENSG00000171466.8ZNF562intronicL1MA4,AluJochr19:9667795-9668326:-.alignment
chr19:9667795-9668326:-ENST00000585350.1ENSG00000171466.8ZNF562intronicL1MA4,AluJochr19:9667795-9668326:-.alignment
chr19:9667795-9668326:-ENST00000585688.4ENSG00000171466.8ZNF562intronicL1MA4,AluJochr19:9667795-9668326:-.alignment
chr19:9667795-9668326:-ENST00000587392.4ENSG00000171466.8ZNF562intronicL1MA4,AluJochr19:9667795-9668326:-.alignment
chr19:9667795-9668326:-ENST00000588653.4ENSG00000171466.8ZNF562intronicL1MA4,AluJochr19:9667795-9668326:-.alignment
chr19:9667795-9668326:-ENST00000589542.1ENSG00000171466.8ZNF562intronicL1MA4,AluJochr19:9667795-9668326:-.alignment
chr19:9667795-9668326:-ENST00000590155.4ENSG00000171466.8ZNF562intronicL1MA4,AluJochr19:9667795-9668326:-.alignment
chr19:9672859-9674507:-ENST00000293648.7ENSG00000171466.8ZNF562intronicLTR10F,LTR10G,AluSq2,AluSxchr19:9672859-9674507:-.alignment
chr19:9672859-9674507:-ENST00000453372.5ENSG00000171466.8ZNF562intronicLTR10F,LTR10G,AluSq2,AluSxchr19:9672859-9674507:-.alignment
chr19:9672859-9674507:-ENST00000585350.1ENSG00000171466.8ZNF562intronicLTR10F,LTR10G,AluSq2,AluSxchr19:9672859-9674507:-.alignment
chr19:9672859-9674507:-ENST00000585688.4ENSG00000171466.8ZNF562intronicLTR10F,LTR10G,AluSq2,AluSxchr19:9672859-9674507:-.alignment
chr19:9672859-9674507:-ENST00000587392.4ENSG00000171466.8ZNF562intronicLTR10F,LTR10G,AluSq2,AluSxchr19:9672859-9674507:-.alignment
chr19:9672859-9674507:-ENST00000588653.4ENSG00000171466.8ZNF562intronicLTR10F,LTR10G,AluSq2,AluSxchr19:9672859-9674507:-.alignment
chr19:9672859-9674507:-ENST00000589542.1ENSG00000171466.8ZNF562intronicLTR10F,LTR10G,AluSq2,AluSxchr19:9672859-9674507:-.alignment
chr19:9672859-9674507:-ENST00000590155.4ENSG00000171466.8ZNF562intronicLTR10F,LTR10G,AluSq2,AluSxchr19:9672859-9674507:-.alignment


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2. Tumor-specific enriched editing regions for ZNF562


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr19:9650657-9650956:-BRCAEER3.1521e-02image
chr19:9646034-9648747:-KIRPEER3.5194e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr19:9646034-9648747:-KIRPCliEER4.0055e-027.1296e-030.2233image
ENSG00000171466.8,ZNF562KIRPCliEAG1.7987e-021.9095e-030.2548image
chr19:9646034-9648747:-MESOPathEER3.4413e-022.9377e-02-0.2468image
ENSG00000171466.8,ZNF562MESOPathEAG2.8529e-021.9041e-02-0.2650image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for ZNF562


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr19:9646034-9648747:-COADEERENSG00000238317,SNORD110.21471.0160e-021.8446e-240.5861imageNNNAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr19:9646034-9648747:-COADEERENSG00000023445,BIRC30.21101.9776e-024.4490e-180.5116imageNDGCR8;EIF4A3;ELAVL1;FBL;NOP56;NOP58;PRPF8;SRSF1;TAF15;U2AF2;UPF1BIRC3Dendritic_cells_activatedGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKB
chr19:9646034-9648747:-COADEERENSG00000129315,CCNT10.20152.6888e-021.6351e-110.4092imageNCNBP;CSTF2T;DDX3X;DGCR8;EIF4A3;ELAVL1;FBL;FMR1;FUS;GNL3;HNRNPA1;HNRNPC;HNRNPM;IGF2BP2;ILF3;KHDRBS1;KHSRP;MOV10;NOP56;NOP58;PRPF8;RBM22;SMNDC1;SND1;SRSF1;TAF15;TARDBP;U2AF2;UPF1CCNT1NeutrophilsGSVA_HALLMARK_XENOBIOTIC_METABOLISM
chr19:9646034-9648747:-COADEERENSG00000110172,CHORDC10.19153.9141e-028.0560e-190.5213imageNCNBP;CSTF2T;DDX3X;DGCR8;EIF4A3;ELAVL1;FBL;FMR1;FUS;GNL3;HNRNPA1;HNRNPC;HNRNPM;IGF2BP2;ILF3;KHDRBS1;KHSRP;MOV10;NOP56;NOP58;PRPF8;RBM22;SMNDC1;SND1;SRSF1;TAF15;TARDBP;U2AF2;UPF1NAEosinophilsGSVA_HALLMARK_P53_PATHWAY
chr19:9646034-9648747:-PCPGEERENSG00000108439,PNPO0.41941.7752e-051.1375e-070.4009imageNCNBP;CSTF2T;DDX3X;DGCR8;EIF4A3;ELAVL1;FBL;FMR1;FUS;GNL3;HNRNPA1;HNRNPC;HNRNPM;IGF2BP2;ILF3;KHDRBS1;KHSRP;MOV10;NOP56;NOP58;PRPF8;SMNDC1;SND1;SRSF1;TAF15;TARDBP;U2AF2;UPF1NAGSVA_HALLMARK_PROTEIN_SECRETION
chr19:9646034-9648747:-PCPGEERENSG00000138459,SLC35A50.40864.3229e-059.4824e-080.4032imageNCNBP;CSTF2T;DDX3X;DGCR8;EIF4A3;ELAVL1;FBL;FMR1;FUS;HNRNPA1;HNRNPC;IGF2BP2;ILF3;KHDRBS1;KHSRP;MOV10;NOP56;NOP58;PRPF8;SMNDC1;SND1;SRSF1;TAF15;TARDBP;U2AF2;UPF1NAB_cells_naiveGSVA_HALLMARK_PROTEIN_SECRETION
chr19:9646034-9648747:-PCPGEERENSG00000166326,TRIM440.40226.6774e-051.7818e-080.4234imageNCNBP;CSTF2T;DDX3X;DGCR8;EIF4A3;ELAVL1;FBL;FMR1;FUS;GNL3;HNRNPA1;HNRNPC;HNRNPM;IGF2BP2;ILF3;KHDRBS1;KHSRP;MOV10;NOP56;NOP58;PRPF8;SMNDC1;SND1;SRSF1;TAF15;TARDBP;U2AF2;UPF1NAMast_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr19:9646034-9648747:-PCPGEERENSG00000148925,BTBD100.39331.0643e-041.0331e-070.4021imageNCNBP;CSTF2T;DDX3X;DGCR8;EIF4A3;ELAVL1;FBL;FMR1;FUS;GNL3;HNRNPA1;HNRNPC;HNRNPM;IGF2BP2;ILF3;MOV10;NOP56;NOP58;PRPF8;SMNDC1;SND1;SRSF1;TAF15;TARDBP;U2AF2;UPF1NAGSVA_HALLMARK_MITOTIC_SPINDLE
chr19:9646034-9648747:-PCPGEERENSG00000179119,SPTY2D10.36963.6062e-047.4263e-080.4062imageNCNBP;CSTF2T;DDX3X;DGCR8;EIF4A3;ELAVL1;FBL;FMR1;FUS;HNRNPA1;HNRNPC;HNRNPM;IGF2BP2;ILF3;KHDRBS1;KHSRP;MOV10;NOP56;NOP58;PRPF8;SMNDC1;SND1;SRSF1;TAF15;TARDBP;U2AF2;UPF1NANeutrophilsGSVA_HALLMARK_UV_RESPONSE_DN
chr19:9646034-9648747:-PCPGEERENSG00000185973,TMLHE0.34531.0389e-031.1678e-080.4284imageNCNBP;CSTF2T;DDX3X;DGCR8;EIF4A3;ELAVL1;FBL;FMR1;FUS;GNL3;HNRNPA1;HNRNPC;HNRNPM;IGF2BP2;ILF3;KHDRBS1;KHSRP;MOV10;NOP56;NOP58;PRPF8;RBM22;SMNDC1;SRSF1;TAF15;TARDBP;U2AF2;UPF1NAT_cells_CD4_memory_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr19:9650657-9650956:-ESCAEERENSG00000135870,RC3H1-0.47392.3390e-055.4005e-07-0.4007imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_DNA_REPAIR
chr19:9650657-9650956:-ESCAEERENSG00000007520,TSR30.44009.1418e-059.3447e-080.4244imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_DNA_REPAIR
chr19:9650657-9650956:-ESCAEERENSG00000167397,VKORC10.44801.0751e-046.4152e-080.4293imageNNVKORC1T_cells_gamma_deltaGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr19:9650657-9650956:-ESCAEERENSG00000168061,SAC3D10.41972.8364e-044.7939e-120.5321imageNNNANK_cells_activatedGSVA_HALLMARK_DNA_REPAIR
chr19:9650657-9650956:-ESCAEERENSG00000116670,MAD2L20.40825.5633e-041.8158e-070.4157imageNNNANK_cells_activatedGSVA_HALLMARK_DNA_REPAIR
chr19:9650657-9650956:-ESCAEERENSG00000034510,TMSB100.40706.7204e-041.9839e-070.4145imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_DNA_REPAIR
chr19:9650657-9650956:-ESCAEERENSG00000175602,CCDC85B0.40288.4831e-043.5145e-070.4067imageNNCCDC85BT_cells_CD4_memory_restingGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr19:9650657-9650956:-ESCAEERENSG00000228499,TMSB10P10.38611.6440e-036.6253e-080.4289imageNNNAT_cells_gamma_deltaGSVA_HALLMARK_BILE_ACID_METABOLISM
chr19:9650657-9650956:-ESCAEERENSG00000226781,TBCAP10.36512.6151e-033.1895e-070.4080imageNNNAT_cells_gamma_deltaGSVA_HALLMARK_MYC_TARGETS_V1
chr19:9650657-9650956:-ESCAEERENSG00000197568,HHLA30.36233.7033e-031.3152e-090.4755imageNNNAT_cells_CD8GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY

More results



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4. Enriched editing regions and immune related splicing for ZNF562


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000171466.8,ZNF562
COADEAGMEXENSG00000110321.11chr1110798991:10799113:10799212:10799266:10799551:10799756:10800089:10800348-0.28173.3616e-035.0044e-13-0.4306imageNACIN1;ADAR;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CBX7;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RBM6;RC3H1;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZFP36;ZNF184NANeutrophilsGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
ENSG00000171466.8,ZNF562
COADEAGMEXENSG00000068912.9chr253797731:53797795:53799046:53799081:53808298:53808460:53809213:538092730.24402.1460e-024.6637e-130.4312imageNACIN1;ADAR;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RBM6;RC3H1;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDF1;YWHAG;ZFP36;ZNF184NAEosinophilsGSVA_HALLMARK_DNA_REPAIR
chr19:9646034-9648747:-
COADEERIRENSG00000154305.12chr1222662055:222662332:222663997:2226640500.24212.4445e-022.5406e-170.5014imageNCNBP;CSTF2T;DDX3X;DGCR8;EIF4A3;ELAVL1;FBL;FMR1;FUS;GNL3;HNRNPA1;HNRNPC;HNRNPM;IGF2BP2;ILF3;KHDRBS1;KHSRP;MOV10;NOP56;NOP58;PRPF8;RBM22;SMNDC1;SND1;SRSF1;TAF15;TARDBP;U2AF2;UPF1MIA3EosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000171466.8,ZNF562
COADEAGIRENSG00000140750.12chr1624959670:24959752:24959910:249599790.24341.6444e-021.1057e-150.4723imageNACIN1;ADAR;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RBM6;RC3H1;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZFP36;ZNF184ARHGAP17EosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000171466.8,ZNF562
COADEAGIRENSG00000132424.10chr699409172:99409344:99410740:994109250.25541.1633e-025.2397e-160.4778imageNACIN1;ADAR;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RC3H1;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZFP36;ZNF184NAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000171466.8,ZNF562
COADEAGIRENSG00000133106.10chr1342969037:42969177:42970611:429706700.24122.2819e-021.9062e-120.4230imageNADAR;CELF2;CNBP;DGCR8;DKC1;EIF4A3;ELAVL1;FBL;FUS;HNRNPC;HNRNPL;IGF2BP2;NOP58;PTBP1;RBFOX2;SRSF3;TAF15;TARDBP;TROVE2;U2AF2;YTHDC1NAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000171466.8,ZNF562
COADEAGIRENSG00000134987.7chr5111091715:111092618:111094919:1110949430.19393.5984e-028.0179e-180.5824imageNACIN1;ALYREF;BCCIP;BUD13;CBX7;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZFP36;ZNF184NADendritic_cells_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000171466.8,ZNF562
COADEAGIRENSG00000128585.13chr7131463216:131463364:131464293:1314644080.20683.6256e-025.7329e-120.4153imageNACIN1;ADAR;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZFP36;ZNF184NAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000171466.8,ZNF562
COADEAGIRENSG00000109606.8chr424539708:24540948:24541872:245418990.23043.6481e-022.4811e-160.4816imageNACIN1;ADAR;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RBM6;RC3H1;RNF219;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZFP36;ZNF184NADendritic_cells_activatedGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000171466.8,ZNF562
COADEAGIRENSG00000135473.10chr1256326312:56326959:56327363:563276310.23981.2851e-022.0554e-150.4900imageNACIN1;ADAR;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RC3H1;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NADendritic_cells_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE

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5. Enriched editing regions and immune infiltration for ZNF562


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr19:9646034-9648747:-BLCAEERMacrophages_M13.1298e-050.2105image
ENSG00000171466.8,ZNF562BLCAEAGMacrophages_M11.0149e-040.1966image
chr19:9646034-9648747:-BRCAEERNK_cells_activated1.5272e-02-0.0749image
chr19:9650657-9650956:-BRCAEERNK_cells_activated1.0837e-030.1288image
ENSG00000171466.8,ZNF562BRCAEAGDendritic_cells_resting2.5781e-02-0.0686image
chr19:9646034-9648747:-CESCEERMast_cells_resting1.8026e-02-0.1398image
ENSG00000171466.8,ZNF562CESCEAGMast_cells_resting1.1034e-02-0.1498image
chr19:9646034-9648747:-COADEERDendritic_cells_activated7.0087e-030.1701image
ENSG00000171466.8,ZNF562COADEAGEosinophils3.4147e-040.2217image
chr19:9646034-9648747:-ESCAEERMacrophages_M11.3220e-020.1955image
chr19:9650657-9650956:-ESCAEERMacrophages_M21.4414e-020.2021image
chr19:9672859-9674507:-ESCAEERNK_cells_activated1.4766e-040.3937image
ENSG00000171466.8,ZNF562ESCAEAGB_cells_naive7.2714e-03-0.2115image
ENSG00000171466.8,ZNF562GBMEAGT_cells_CD4_memory_resting3.6298e-020.1646image
chr19:9646034-9648747:-HNSCEERPlasma_cells2.5817e-03-0.1394image
chr19:9650657-9650956:-HNSCEERNK_cells_resting1.2601e-020.1672image
ENSG00000171466.8,ZNF562HNSCEAGPlasma_cells8.2480e-04-0.1538image
ENSG00000171466.8,ZNF562KICHEAGT_cells_CD81.3522e-020.3342image
chr19:9646034-9648747:-KIRCEERB_cells_memory1.5668e-030.1716image
chr19:9650657-9650956:-KIRCEERPlasma_cells2.9632e-020.1946image
ENSG00000171466.8,ZNF562KIRCEAGB_cells_memory1.5377e-030.1692image
chr19:9646034-9648747:-KIRPEERMacrophages_M11.2986e-030.2210image
ENSG00000171466.8,ZNF562KIRPEAGMacrophages_M11.0512e-030.2235image
ENSG00000171466.8,ZNF562LAMLEAGT_cells_regulatory_(Tregs)9.9601e-030.2394image
ENSG00000171466.8,ZNF562LGGEAGNeutrophils3.2919e-030.1433image
chr19:9646034-9648747:-LIHCEERT_cells_regulatory_(Tregs)2.3403e-03-0.1828image
ENSG00000171466.8,ZNF562LIHCEAGT_cells_regulatory_(Tregs)1.3372e-03-0.1918image
chr19:9646034-9648747:-LUADEERNeutrophils1.4672e-02-0.1191image
ENSG00000171466.8,ZNF562LUADEAGNeutrophils2.7766e-02-0.1066image
chr19:9646034-9648747:-LUSCEERMacrophages_M25.7503e-030.1287image
ENSG00000171466.8,ZNF562LUSCEAGMacrophages_M24.1131e-030.1334image
chr19:9646034-9648747:-MESOEERT_cells_follicular_helper1.2868e-020.2879image
ENSG00000171466.8,ZNF562MESOEAGT_cells_follicular_helper1.5417e-020.2807image
chr19:9646034-9648747:-OVEERT_cells_CD83.3363e-040.2110image
chr19:9650657-9650956:-OVEERNK_cells_resting1.3729e-03-0.2174image
chr19:9663735-9664296:-OVEERT_cells_CD4_memory_activated4.2819e-020.4458image
ENSG00000171466.8,ZNF562OVEAGT_cells_CD81.2158e-040.2253image
chr19:9646034-9648747:-PRADEERT_cells_CD4_memory_resting1.4314e-020.1105image
ENSG00000171466.8,ZNF562PRADEAGT_cells_CD4_memory_resting2.6845e-030.1350image
chr19:9646034-9648747:-SARCEERDendritic_cells_resting9.8017e-030.1711image
ENSG00000171466.8,ZNF562SARCEAGDendritic_cells_resting1.3292e-020.1638image
chr19:9646034-9648747:-STADEERT_cells_CD4_memory_activated3.7593e-050.2169image
chr19:9650657-9650956:-STADEEREosinophils3.8062e-030.1700image
chr19:9663735-9664296:-STADEERPlasma_cells4.5420e-020.3356image
ENSG00000171466.8,ZNF562STADEAGT_cells_CD4_memory_activated1.7227e-020.1260image
chr19:9646034-9648747:-TGCTEERDendritic_cells_resting2.3850e-02-0.2054image
ENSG00000171466.8,ZNF562TGCTEAGT_cells_regulatory_(Tregs)2.7867e-02-0.2000image
chr19:9646034-9648747:-THCAEERNeutrophils2.2030e-020.1088image
ENSG00000171466.8,ZNF562THCAEAGNeutrophils3.5568e-020.0989image
ENSG00000171466.8,ZNF562THYMEAGT_cells_regulatory_(Tregs)1.4131e-02-0.2485image
chr19:9650657-9650956:-UCECEERNK_cells_resting2.8571e-02-0.3341image
ENSG00000171466.8,ZNF562UCECEAGEosinophils2.0726e-020.1763image


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6. Enriched editing regions and immune gene sets for ZNF562


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr19:9646034-9648747:-HNSCEER2.9282e-02image1.0673e-060.2240image
ENSG00000171466.8,ZNF562HNSCEAG3.2841e-02image8.1954e-050.1807image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000171466.8,ZNF562BRCAEAG1.3764e-020.07586.6527e-030.08343.3523e-020.06541.2024e-050.1342image
ENSG00000171466.8,ZNF562ESCAEAG5.6321e-050.31283.9946e-020.16268.2710e-040.26185.8250e-030.2171image
chr19:9646034-9648747:-ESCAEER5.2396e-040.27122.6297e-020.17573.6397e-030.22866.7784e-030.2132image
chr19:9650657-9650956:-ESCAEER8.8105e-060.35863.6954e-030.23885.0905e-050.32881.7366e-020.1966image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000171466.8,ZNF562BLCAGSVA_HALLMARK_MTORC1_SIGNALINGEAG1.5864e-060.2415image
chr19:9646034-9648747:-BLCAGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER3.4337e-070.2563image
ENSG00000171466.8,ZNF562BRCAGSVA_HALLMARK_GLYCOLYSISEAG2.6486e-070.1575image
chr19:9646034-9648747:-BRCAGSVA_HALLMARK_ANDROGEN_RESPONSEEER3.0311e-130.2226image
chr19:9650657-9650956:-BRCAGSVA_HALLMARK_GLYCOLYSISEER3.5924e-060.1819image
ENSG00000171466.8,ZNF562CESCGSVA_HALLMARK_MITOTIC_SPINDLEEAG6.6213e-030.1599image
chr19:9646034-9648747:-CESCGSVA_HALLMARK_MITOTIC_SPINDLEEER1.6026e-030.1858image
chr19:9646034-9648747:-CHOLGSVA_HALLMARK_ANDROGEN_RESPONSEEER4.4102e-020.3765image
chr19:9646034-9648747:-COADGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER9.9582e-03-0.1627image
ENSG00000171466.8,ZNF562COADGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG1.1262e-04-0.2386image
ENSG00000171466.8,ZNF562DLBCGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.9683e-020.3925image
chr19:9672859-9674507:-ESCAGSVA_HALLMARK_GLYCOLYSISEER2.3531e-020.2413image
chr19:9646034-9648747:-ESCAGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER3.2775e-040.2805image
ENSG00000171466.8,ZNF562ESCAGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.3593e-03-0.2511image
chr19:9650657-9650956:-ESCAGSVA_HALLMARK_DNA_REPAIREER1.1564e-040.3137image
ENSG00000171466.8,ZNF562GBMGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG1.9716e-040.2885image
chr19:9646034-9648747:-GBMGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER5.7030e-040.2678image
chr19:9650657-9650956:-HNSCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER8.9523e-040.2214image
ENSG00000171466.8,ZNF562HNSCGSVA_HALLMARK_HYPOXIAEAG4.5686e-080.2489image
chr19:9646034-9648747:-HNSCGSVA_HALLMARK_HYPOXIAEER1.5656e-090.2753image
ENSG00000171466.8,ZNF562KICHGSVA_HALLMARK_E2F_TARGETSEAG1.8650e-020.3192image
ENSG00000171466.8,ZNF562KIRCGSVA_HALLMARK_SPERMATOGENESISEAG1.0501e-040.2064image
chr19:9646034-9648747:-KIRCGSVA_HALLMARK_SPERMATOGENESISEER1.9187e-060.2560image
chr19:9650657-9650956:-KIRCGSVA_HALLMARK_COAGULATIONEER1.9972e-030.2739image
chr19:9646034-9648747:-KIRPGSVA_HALLMARK_MTORC1_SIGNALINGEER9.6659e-030.1786image
ENSG00000171466.8,ZNF562KIRPGSVA_HALLMARK_MTORC1_SIGNALINGEAG1.2956e-020.1704image
ENSG00000171466.8,ZNF562LAMLGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.5586e-02-0.2251image
ENSG00000171466.8,ZNF562LGGGSVA_HALLMARK_UV_RESPONSE_DNEAG5.4142e-060.2201image
chr19:9646034-9648747:-LGGGSVA_HALLMARK_PROTEIN_SECRETIONEER1.6243e-040.1891image
chr19:9646034-9648747:-LIHCGSVA_HALLMARK_HEME_METABOLISMEER6.2679e-050.2389image
ENSG00000171466.8,ZNF562LIHCGSVA_HALLMARK_HEME_METABOLISMEAG2.0937e-050.2526image
ENSG00000171466.8,ZNF562LUADGSVA_HALLMARK_PROTEIN_SECRETIONEAG5.1806e-040.1675image
chr19:9646034-9648747:-LUADGSVA_HALLMARK_PROTEIN_SECRETIONEER6.9387e-040.1651image
ENSG00000171466.8,ZNF562LUSCGSVA_HALLMARK_GLYCOLYSISEAG4.7357e-020.0924image
chr19:9646034-9648747:-LUSCGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER4.2542e-020.0947image
chr19:9646034-9648747:-MESOGSVA_HALLMARK_KRAS_SIGNALING_UPEER3.1888e-02-0.2497image
ENSG00000171466.8,ZNF562MESOGSVA_HALLMARK_KRAS_SIGNALING_UPEAG3.7738e-02-0.2420image
chr19:9650657-9650956:-OVGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER3.1761e-07-0.3410image
chr19:9646034-9648747:-OVGSVA_HALLMARK_UV_RESPONSE_UPEER2.2258e-100.3644image
ENSG00000171466.8,ZNF562OVGSVA_HALLMARK_UV_RESPONSE_UPEAG3.4390e-100.3602image
ENSG00000171466.8,ZNF562PAADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.2428e-03-0.2539image
chr19:9646034-9648747:-PAADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.9154e-03-0.2450image
chr19:9646034-9648747:-PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEER6.2233e-060.3456image
ENSG00000171466.8,ZNF562PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.0897e-070.3909image
ENSG00000171466.8,ZNF562PRADGSVA_HALLMARK_P53_PATHWAYEAG2.6076e-02-0.1003image
chr19:9646034-9648747:-READGSVA_HALLMARK_UV_RESPONSE_DNEER5.2019e-030.2922image
ENSG00000171466.8,ZNF562READGSVA_HALLMARK_UV_RESPONSE_DNEAG2.2059e-030.3170image
chr19:9646034-9648747:-SARCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER2.3841e-02-0.1500image
ENSG00000171466.8,ZNF562SARCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.3581e-02-0.1633image
ENSG00000171466.8,ZNF562SKCMGSVA_HALLMARK_HYPOXIAEAG4.9942e-030.1379image
chr19:9646034-9648747:-SKCMGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER1.3586e-020.1221image
ENSG00000171466.8,ZNF562STADGSVA_HALLMARK_UV_RESPONSE_DNEAG1.4085e-04-0.2001image
chr19:9646034-9648747:-STADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER1.4156e-060.2527image
chr19:9650657-9650956:-STADGSVA_HALLMARK_UV_RESPONSE_DNEER2.1210e-04-0.2166image
chr19:9663735-9664296:-STADGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER2.9299e-020.3635image
chr19:9646034-9648747:-TGCTGSVA_HALLMARK_ANDROGEN_RESPONSEEER2.0999e-050.3763image
ENSG00000171466.8,ZNF562TGCTGSVA_HALLMARK_ANDROGEN_RESPONSEEAG4.3207e-060.4040image
chr19:9646034-9648747:-THCAGSVA_HALLMARK_ANDROGEN_RESPONSEEER6.9669e-060.2117image
ENSG00000171466.8,ZNF562THCAGSVA_HALLMARK_ANDROGEN_RESPONSEEAG8.9064e-050.1833image
ENSG00000171466.8,ZNF562THYMGSVA_HALLMARK_DNA_REPAIREAG5.0332e-04-0.3467image
chr19:9646034-9648747:-UCECGSVA_HALLMARK_MYOGENESISEER6.2525e-030.2083image
chr19:9650657-9650956:-UCECGSVA_HALLMARK_DNA_REPAIREER1.7309e-020.3612image
ENSG00000171466.8,ZNF562UCECGSVA_HALLMARK_MYOGENESISEAG9.6897e-030.1967image
chr19:9646034-9648747:-UCSGSVA_HALLMARK_COAGULATIONEER1.0359e-020.3560image
ENSG00000171466.8,ZNF562UCSGSVA_HALLMARK_COAGULATIONEAG2.4412e-020.3149image


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7. Enriched editing regions and drugs for ZNF562


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr19:9646034-9648747:-ACCBMS.536924EER7.0592e-030.3593image
ENSG00000171466.8,ZNF562ACCBortezomibEAG4.2720e-030.3762image
ENSG00000171466.8,ZNF562BLCABMS.708163EAG1.3940e-05-0.2192image
chr19:9646034-9648747:-BLCACMKEER1.7240e-05-0.2171image
ENSG00000171466.8,ZNF562BRCAKIN001.135EAG8.3784e-05-0.1207image
chr19:9650657-9650956:-BRCACCT007093EER1.9301e-030.1222image
chr19:9646034-9648747:-BRCAKIN001.135EER4.7025e-06-0.1408image
ENSG00000171466.8,ZNF562CESCJNK.9LEAG7.4288e-050.2317image
chr19:9646034-9648747:-CESCCEP.701EER1.1820e-030.1908image
ENSG00000171466.8,ZNF562CHOLBMS.536924EAG2.6409e-020.4119image
chr19:9646034-9648747:-CHOLBMS.536924EER2.2727e-020.4216image
ENSG00000171466.8,ZNF562COADGW843682XEAG3.3188e-080.3361image
chr19:9646034-9648747:-COADABT.263EER6.3392e-04-0.2146image
ENSG00000171466.8,ZNF562DLBCBosutinibEAG1.3933e-02-0.4179image
ENSG00000171466.8,ZNF562ESCAAZD.2281EAG1.1387e-04-0.3013image
chr19:9650657-9650956:-ESCACGP.60474EER8.7881e-07-0.3938image
chr19:9672859-9674507:-ESCABryostatin.1EER3.2782e-03-0.3101image
chr19:9646034-9648747:-ESCABIRB.0796EER2.5945e-03-0.2366image
chr19:9646034-9648747:-GBMMetforminEER1.7218e-02-0.1869image
ENSG00000171466.8,ZNF562GBMBIRB.0796EAG9.0075e-030.2046image
ENSG00000171466.8,ZNF562HNSCElesclomolEAG1.3845e-050.1990image
chr19:9650657-9650956:-HNSCCCT007093EER9.1533e-040.2210image
chr19:9646034-9648747:-HNSCEmbelinEER2.6184e-07-0.2360image
ENSG00000171466.8,ZNF562KICHIPA.3EAG2.5023e-02-0.3048image
ENSG00000171466.8,ZNF562KIRCBIRB.0796EAG2.2957e-030.1632image
chr19:9646034-9648747:-KIRCDoxorubicinEER3.5790e-030.1583image
chr19:9650657-9650956:-KIRCBMS.509744EER7.1372e-06-0.3895image
ENSG00000171466.8,ZNF562KIRPAZD6244EAG4.5861e-040.2386image
chr19:9646034-9648747:-KIRPGDC.0449EER5.7158e-040.2363image
chr19:9646034-9648747:-LAMLMidostaurinEER1.0652e-020.2680image
ENSG00000171466.8,ZNF562LGGBMS.708163EAG1.4819e-02-0.1190image
ENSG00000171466.8,ZNF562LIHCAZD.2281EAG4.4147e-040.2128image
chr19:9646034-9648747:-LIHCAZD.2281EER6.3901e-040.2077image
chr19:9646034-9648747:-LUADGW.441756EER1.2999e-02-0.1213image
ENSG00000171466.8,ZNF562LUADGW.441756EAG9.8383e-03-0.1250image
chr19:9646034-9648747:-LUSCBMS.754807EER2.7714e-02-0.1028image
ENSG00000171466.8,ZNF562LUSCImatinibEAG3.1930e-02-0.0999image
chr19:9646034-9648747:-MESOAZD7762EER3.3037e-030.3372image
ENSG00000171466.8,ZNF562MESOAZD7762EAG2.2348e-030.3500image
ENSG00000171466.8,ZNF562OVA.770041EAG7.2723e-10-0.3539image
chr19:9663735-9664296:-OVAZD6244EER1.7774e-02-0.5115image
chr19:9646034-9648747:-OVA.770041EER2.7650e-07-0.2987image
chr19:9650657-9650956:-OVA.770041EER2.7145e-09-0.3925image
ENSG00000171466.8,ZNF562PAADMetforminEAG9.4809e-040.2597image
chr19:9646034-9648747:-PAADDMOGEER5.7219e-03-0.2203image
chr19:9646034-9648747:-PCPGGDC.0449EER8.4786e-040.2589image
ENSG00000171466.8,ZNF562PCPGGDC.0449EAG1.3374e-040.2930image
chr19:9646034-9648747:-PRADMetforminEER1.2920e-020.1121image
ENSG00000171466.8,ZNF562PRADMetforminEAG6.8795e-030.1217image
ENSG00000171466.8,ZNF562READAG.014699EAG7.6659e-03-0.2778image
chr19:9646034-9648747:-READBX.795EER7.4325e-03-0.2804image
chr19:9646034-9648747:-SARCDMOGEER6.9300e-03-0.1788image
ENSG00000171466.8,ZNF562SARCLFM.A13EAG2.5369e-03-0.1990image
ENSG00000171466.8,ZNF562SKCMAZD7762EAG3.1269e-04-0.1767image
chr19:9646034-9648747:-SKCMJNJ.26854165EER3.4293e-04-0.1764image
chr19:9646034-9648747:-STADCCT007093EER4.3412e-040.1858image
chr19:9650657-9650956:-STADEmbelinEER7.2294e-050.2317image
chr19:9663735-9664296:-STADCCT018159EER2.2410e-02-0.3796image
ENSG00000171466.8,ZNF562STADAS601245EAG2.8435e-030.1575image
chr19:9646034-9648747:-TGCTCytarabineEER2.3105e-04-0.3288image
ENSG00000171466.8,ZNF562TGCTCytarabineEAG1.3896e-04-0.3395image
chr19:9646034-9648747:-THCACEP.701EER2.2621e-040.1746image
ENSG00000171466.8,ZNF562THCACEP.701EAG1.7279e-030.1472image
ENSG00000171466.8,ZNF562THYMAKT.inhibitor.VIIIEAG1.3114e-03-0.3217image
chr19:9650657-9650956:-UCECAKT.inhibitor.VIIIEER4.3005e-020.3101image
chr19:9646034-9648747:-UCECAP.24534EER2.2726e-03-0.2319image
ENSG00000171466.8,ZNF562UCECAP.24534EAG1.8346e-03-0.2359image
chr19:9646034-9648747:-UCSDasatinibEER4.4851e-02-0.2822image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType