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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: CTSA (ImmuneEditome ID:5476)

1. Gene summary of enriched editing regions for CTSA

check button Gene summary
Gene informationGene symbol

CTSA

Gene ID

5476

GeneSynonymsGLB2|GSL|NGBE|PPCA|PPGB
GeneCytomap

20q13.12

GeneTypeprotein-coding
GeneDescriptionlysosomal protective protein|beta-galactosidase 2|beta-galactosidase protective protein|carboxypeptidase C|carboxypeptidase Y-like kininase|carboxypeptidase-L|deamidase|lysosomal carboxypeptidase A|protective protein cathepsin A|urinary kininase
GeneModificationdate20230329
UniprotIDX6R8A1;P10619;U3KQU6;A0A7I2YQT8;A0A7I2V4R8;A0A7I2V2E2;A0A7I2V4Q9;A0A7I2V3M2;Q5JZH0;U3KQF1;A0A7I2V4K5;A0A7I2V3B2;A0A7I2V504;A0A7I2V4D1
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr20:45895311-45896621:+ENST00000484855.2ENSG00000064601.15CTSAncRNA_exonicMER20B,AluSq,AluJo,AluJr,AluSgchr20:45895311-45896621:+.alignment
chr20:45895311-45896621:+ENST00000607187.1ENSG00000064601.15CTSAncRNA_exonicMER20B,AluSq,AluJo,AluJr,AluSgchr20:45895311-45896621:+.alignment


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2. Tumor-specific enriched editing regions for CTSA


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for CTSA


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr20:45895311-45896621:+GBMEERENSG00000126767,ELK10.44416.2986e-059.3304e-070.4047imageNCNBP;DDX54;DHX9;ELAVL1;FBL;FUS;HNRNPA1;HNRNPK;HNRNPL;IGF2BP2;NOP56;TARDBP;U2AF2ELK1GSVA_HALLMARK_SPERMATOGENESIS
chr20:45895311-45896621:+LAMLEERENSG00000169398,PTK20.31284.7761e-023.9092e-130.5480imageNCNBP;DDX54;DHX9;ELAVL1;FBL;FUS;HNRNPA1;HNRNPK;HNRNPL;IGF2BP2;NOP56;TARDBP;U2AF2PTK2T_cells_CD4_memory_activatedGSVA_HALLMARK_TGF_BETA_SIGNALING
chr20:45895311-45896621:+GBMEERENSG00000126767,ELK10.44416.2986e-059.3304e-070.4047imageNCNBP;DDX54;DHX9;ELAVL1;FBL;FUS;HNRNPA1;HNRNPK;HNRNPL;IGF2BP2;NOP56;TARDBP;U2AF2ELK1GSVA_HALLMARK_SPERMATOGENESIS
chr20:45895311-45896621:+LAMLEERENSG00000169398,PTK20.31284.7761e-023.9092e-130.5480imageNCNBP;DDX54;DHX9;ELAVL1;FBL;FUS;HNRNPA1;HNRNPK;HNRNPL;IGF2BP2;NOP56;TARDBP;U2AF2PTK2T_cells_CD4_memory_activatedGSVA_HALLMARK_TGF_BETA_SIGNALING

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4. Enriched editing regions and immune related splicing for CTSA


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr20:45895311-45896621:+
GBMEERIRENSG00000064601.12chr2045896964:45897806:45898004:45898109-0.38844.2528e-031.7925e-07-0.4282imageNCNBP;DDX54;DHX9;ELAVL1;FBL;FUS;HNRNPA1;HNRNPK;HNRNPL;IGF2BP2;NOP56;TARDBP;U2AF2CTSAT_cells_CD4_memory_restingGSVA_HALLMARK_MYC_TARGETS_V1
ENSG00000064601.15,CTSA
GBMEAGIRENSG00000064601.12chr2045896380:45898109:45898366:45898528-0.35171.8263e-022.1668e-07-0.4256imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL1;MBNL2;METTL14;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184CTSANK_cells_activatedGSVA_HALLMARK_MYC_TARGETS_V2
chr20:45895311-45896621:+
GBMEERIRENSG00000064601.12chr2045896380:45898109:45898366:45898528-0.35171.5601e-022.1668e-07-0.4256imageNCNBP;DDX54;DHX9;ELAVL1;FBL;FUS;HNRNPA1;HNRNPK;HNRNPL;IGF2BP2;NOP56;TARDBP;U2AF2CTSANK_cells_activatedGSVA_HALLMARK_MYC_TARGETS_V2
ENSG00000064601.15,CTSA
GBMEAGIRENSG00000064601.12chr2045896964:45897806:45898004:45898109-0.38844.9252e-031.7925e-07-0.4282imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL1;MBNL2;METTL14;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184CTSAT_cells_CD4_memory_restingGSVA_HALLMARK_MYC_TARGETS_V1
ENSG00000064601.15,CTSA
OVEAGIRENSG00000250151.5chr39812942:9813111:9813247:98133450.25322.1268e-034.3015e-120.4302imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL1;MBNL2;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAEosinophilsGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr20:45895311-45896621:+
OVEERIRENSG00000131732.7chr581301589:81301670:81304740:81305141-0.34703.1930e-073.0750e-10-0.4133imageNCNBP;DDX54;DHX9;ELAVL1;FBL;FUS;HNRNPA1;HNRNPK;HNRNPL;IGF2BP2;NOP56;TARDBP;U2AF2NANK_cells_restingGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr20:45895311-45896621:+
OVEERIRENSG00000250151.5chr39812942:9813111:9813247:98133450.25241.9584e-034.6303e-120.4296imageNCNBP;DDX54;DHX9;ELAVL1;FBL;FUS;HNRNPA1;HNRNPK;HNRNPL;IGF2BP2;NOP56;TARDBP;U2AF2NAEosinophilsGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
ENSG00000064601.15,CTSA
OVEAGIRENSG00000131732.7chr581301589:81301670:81304740:81305141-0.34772.3039e-072.9823e-10-0.4136imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM47;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YWHAG;ZNF184NANK_cells_restingGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr20:45895311-45896621:+
STADEERIRENSG00000178188.10chr1628863804:28863945:28866011:28866264-0.34391.7610e-075.6314e-13-0.4139imageNCNBP;DDX54;DHX9;ELAVL1;FBL;FUS;HNRNPA1;HNRNPK;HNRNPL;IGF2BP2;NOP56;TARDBP;U2AF2NAT_cells_CD8GSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
ENSG00000064601.15,CTSA
STADEAGIRENSG00000178188.10chr1628863804:28863945:28866011:28866264-0.34482.1815e-075.6314e-13-0.4139imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAT_cells_CD8GSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY

More results



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5. Enriched editing regions and immune infiltration for CTSA


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr20:45895311-45896621:+ACCEERDendritic_cells_resting1.0060e-030.3929image
ENSG00000064601.15,CTSAACCEAGDendritic_cells_resting1.0060e-030.3929image
chr20:45895311-45896621:+BLCAEERT_cells_regulatory_(Tregs)3.4752e-02-0.2125image
ENSG00000064601.15,CTSABLCAEAGT_cells_regulatory_(Tregs)3.4752e-02-0.2125image
chr20:45895311-45896621:+BRCAEERMacrophages_M01.0891e-020.1651image
ENSG00000064601.15,CTSABRCAEAGMacrophages_M09.8206e-030.1671image
chr20:45895311-45896621:+COADEERPlasma_cells1.8967e-020.1803image
ENSG00000064601.15,CTSACOADEAGPlasma_cells1.8967e-020.1803image
chr20:45895311-45896621:+GBMEERMacrophages_M27.7491e-03-0.2266image
ENSG00000064601.15,CTSAGBMEAGMacrophages_M27.7491e-03-0.2266image
chr20:45895311-45896621:+KICHEERMonocytes3.5381e-020.3921image
ENSG00000064601.15,CTSAKICHEAGMonocytes3.5381e-020.3921image
chr20:45895311-45896621:+KIRCEERMacrophages_M21.7101e-02-0.1710image
ENSG00000064601.15,CTSAKIRCEAGMacrophages_M21.7101e-02-0.1710image
chr20:45895311-45896621:+KIRPEERDendritic_cells_activated4.0828e-02-0.1640image
ENSG00000064601.15,CTSAKIRPEAGDendritic_cells_activated4.0828e-02-0.1640image
chr20:45895311-45896621:+LAMLEERT_cells_CD4_memory_activated4.2456e-030.2322image
ENSG00000064601.15,CTSALAMLEAGT_cells_CD4_memory_activated4.2456e-030.2322image
chr20:45895311-45896621:+LUADEERDendritic_cells_resting4.7425e-020.1292image
ENSG00000064601.15,CTSALUADEAGDendritic_cells_resting4.7137e-020.1294image
chr20:45895311-45896621:+LUSCEERT_cells_CD83.5618e-020.1538image
ENSG00000064601.15,CTSALUSCEAGT_cells_CD83.5618e-020.1538image
chr20:45895311-45896621:+OVEERDendritic_cells_activated1.7778e-040.2300image
ENSG00000064601.15,CTSAOVEAGDendritic_cells_activated1.7321e-040.2304image
chr20:45895311-45896621:+PAADEERMacrophages_M16.8156e-030.3021image
ENSG00000064601.15,CTSAPAADEAGMacrophages_M16.8156e-030.3021image
chr20:45895311-45896621:+PCPGEERNeutrophils1.1875e-030.4780image
ENSG00000064601.15,CTSAPCPGEAGNeutrophils1.0916e-030.4811image
chr20:45895311-45896621:+PRADEERDendritic_cells_activated5.2984e-040.6428image
ENSG00000064601.15,CTSAPRADEAGDendritic_cells_activated5.2984e-040.6428image
chr20:45895311-45896621:+READEERDendritic_cells_activated3.2245e-020.2680image
ENSG00000064601.15,CTSAREADEAGDendritic_cells_activated3.2245e-020.2680image
chr20:45895311-45896621:+SARCEERDendritic_cells_resting2.8113e-030.2929image
ENSG00000064601.15,CTSASARCEAGDendritic_cells_resting2.8113e-030.2929image
chr20:45895311-45896621:+SKCMEERT_cells_regulatory_(Tregs)1.3640e-020.1558image
ENSG00000064601.15,CTSASKCMEAGT_cells_regulatory_(Tregs)1.3640e-020.1558image
chr20:45895311-45896621:+STADEERMast_cells_activated7.8604e-03-0.1527image
ENSG00000064601.15,CTSASTADEAGNK_cells_activated7.2197e-030.1543image
chr20:45895311-45896621:+TGCTEERB_cells_memory1.5058e-060.5025image
ENSG00000064601.15,CTSATGCTEAGB_cells_memory1.5058e-060.5025image
ENSG00000064601.15,CTSATHYMEAGEosinophils1.6026e-080.7835image
chr20:45895311-45896621:+UCSEERT_cells_gamma_delta1.3342e-050.7763image
ENSG00000064601.15,CTSAUCSEAGT_cells_gamma_delta1.3342e-050.7763image
chr20:45895311-45896621:+UVMEERT_cells_gamma_delta3.9739e-020.4631image
ENSG00000064601.15,CTSAUVMEAGT_cells_gamma_delta3.9739e-020.4631image


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6. Enriched editing regions and immune gene sets for CTSA


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr20:45895311-45896621:+BLCAGSVA_HALLMARK_APICAL_JUNCTIONEER1.2365e-020.2506image
ENSG00000064601.15,CTSABLCAGSVA_HALLMARK_APICAL_JUNCTIONEAG1.2365e-020.2506image
chr20:45895311-45896621:+BRCAGSVA_HALLMARK_GLYCOLYSISEER1.2194e-020.1626image
ENSG00000064601.15,CTSABRCAGSVA_HALLMARK_NOTCH_SIGNALINGEAG1.5150e-020.1573image
ENSG00000064601.15,CTSACESCGSVA_HALLMARK_APICAL_SURFACEEAG1.0891e-020.3026image
chr20:45895311-45896621:+CESCGSVA_HALLMARK_APICAL_SURFACEEER1.0891e-020.3026image
chr20:45895311-45896621:+COADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER2.6216e-020.1710image
ENSG00000064601.15,CTSACOADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG2.6216e-020.1710image
ENSG00000064601.15,CTSAESCAGSVA_HALLMARK_HYPOXIAEAG4.2408e-030.2346image
chr20:45895311-45896621:+ESCAGSVA_HALLMARK_HYPOXIAEER4.2408e-030.2346image
chr20:45895311-45896621:+GBMGSVA_HALLMARK_MYC_TARGETS_V2EER1.7769e-020.2023image
ENSG00000064601.15,CTSAGBMGSVA_HALLMARK_MYC_TARGETS_V2EAG1.7769e-020.2023image
ENSG00000064601.15,CTSAHNSCGSVA_HALLMARK_ADIPOGENESISEAG2.2620e-04-0.6244image
chr20:45895311-45896621:+HNSCGSVA_HALLMARK_ADIPOGENESISEER2.2620e-04-0.6244image
chr20:45895311-45896621:+KICHGSVA_HALLMARK_NOTCH_SIGNALINGEER7.6636e-030.4850image
ENSG00000064601.15,CTSAKICHGSVA_HALLMARK_NOTCH_SIGNALINGEAG7.6636e-030.4850image
chr20:45895311-45896621:+KIRCGSVA_HALLMARK_IL2_STAT5_SIGNALINGEER3.9407e-030.2061image
ENSG00000064601.15,CTSAKIRCGSVA_HALLMARK_IL2_STAT5_SIGNALINGEAG3.9407e-030.2061image
chr20:45895311-45896621:+LAMLGSVA_HALLMARK_UV_RESPONSE_DNEER2.0164e-020.1896image
ENSG00000064601.15,CTSALAMLGSVA_HALLMARK_UV_RESPONSE_DNEAG2.0164e-020.1896image
chr20:45895311-45896621:+LGGGSVA_HALLMARK_MYC_TARGETS_V2EER5.7824e-030.1464image
ENSG00000064601.15,CTSALGGGSVA_HALLMARK_MYC_TARGETS_V2EAG5.3459e-030.1475image
chr20:45895311-45896621:+LUADGSVA_HALLMARK_TGF_BETA_SIGNALINGEER1.9143e-020.1524image
ENSG00000064601.15,CTSALUADGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG1.9105e-020.1525image
chr20:45895311-45896621:+LUSCGSVA_HALLMARK_FATTY_ACID_METABOLISMEER4.1839e-020.1490image
ENSG00000064601.15,CTSALUSCGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG4.1839e-020.1490image
ENSG00000064601.15,CTSAOVGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG8.5302e-080.3241image
chr20:45895311-45896621:+OVGSVA_HALLMARK_PANCREAS_BETA_CELLSEER8.6368e-080.3239image
ENSG00000064601.15,CTSAPAADGSVA_HALLMARK_APOPTOSISEAG2.4197e-020.2535image
chr20:45895311-45896621:+PAADGSVA_HALLMARK_APOPTOSISEER2.4197e-020.2535image
chr20:45895311-45896621:+PCPGGSVA_HALLMARK_DNA_REPAIREER4.2656e-02-0.3106image
ENSG00000064601.15,CTSAPCPGGSVA_HALLMARK_DNA_REPAIREAG3.9989e-02-0.3145image
ENSG00000064601.15,CTSAPRADGSVA_HALLMARK_MITOTIC_SPINDLEEAG8.1396e-03-0.5170image
chr20:45895311-45896621:+PRADGSVA_HALLMARK_MITOTIC_SPINDLEEER8.1396e-03-0.5170image
ENSG00000064601.15,CTSASARCGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.5779e-02-0.2385image
chr20:45895311-45896621:+SARCGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.5779e-02-0.2385image
chr20:45895311-45896621:+SKCMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.6952e-040.2285image
ENSG00000064601.15,CTSASKCMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.6952e-040.2285image
chr20:45895311-45896621:+STADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.7113e-030.1720image
ENSG00000064601.15,CTSASTADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.4900e-030.1734image
chr20:45895311-45896621:+TGCTGSVA_HALLMARK_PEROXISOMEEER3.8971e-020.2285image
ENSG00000064601.15,CTSATGCTGSVA_HALLMARK_PEROXISOMEEAG3.8971e-020.2285image
ENSG00000064601.15,CTSATHCAGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG1.1288e-020.2365image
chr20:45895311-45896621:+THCAGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER1.2624e-020.2330image
ENSG00000064601.15,CTSATHYMGSVA_HALLMARK_PEROXISOMEEAG1.0918e-020.4193image
chr20:45895311-45896621:+UCECGSVA_HALLMARK_TGF_BETA_SIGNALINGEER1.3251e-02-0.4147image
ENSG00000064601.15,CTSAUCECGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG1.3251e-02-0.4147image
ENSG00000064601.15,CTSAUCSGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG1.6788e-020.4932image
chr20:45895311-45896621:+UCSGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER1.6788e-020.4932image


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7. Enriched editing regions and drugs for CTSA


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000064601.15,CTSABLCABIRB.0796EAG1.2716e-020.2496image
chr20:45895311-45896621:+BLCABIRB.0796EER1.2716e-020.2496image
chr20:45895311-45896621:+BRCAAMG.706EER2.0677e-030.1991image
ENSG00000064601.15,CTSABRCAAMG.706EAG1.8629e-030.2007image
ENSG00000064601.15,CTSACESCDMOGEAG3.3638e-02-0.2543image
chr20:45895311-45896621:+CESCDMOGEER3.3638e-02-0.2543image
chr20:45895311-45896621:+COADBMS.708163EER2.3116e-02-0.1747image
ENSG00000064601.15,CTSACOADBMS.708163EAG2.3116e-02-0.1747image
chr20:45895311-45896621:+ESCAAZD.0530EER1.1216e-03-0.2661image
ENSG00000064601.15,CTSAESCAAZD.0530EAG1.1216e-03-0.2661image
chr20:45895311-45896621:+GBMKIN001.135EER1.0533e-03-0.2769image
ENSG00000064601.15,CTSAGBMKIN001.135EAG1.0533e-03-0.2769image
chr20:45895311-45896621:+KICHBMS.754807EER9.6212e-05-0.6606image
ENSG00000064601.15,CTSAKICHBMS.754807EAG9.6212e-05-0.6606image
ENSG00000064601.15,CTSAKIRCCHIR.99021EAG8.6168e-04-0.2373image
chr20:45895311-45896621:+KIRCCHIR.99021EER8.6168e-04-0.2373image
chr20:45895311-45896621:+KIRPBIRB.0796EER3.5169e-020.1688image
ENSG00000064601.15,CTSAKIRPBIRB.0796EAG3.5169e-020.1688image
ENSG00000064601.15,CTSALAMLCisplatinEAG2.2586e-03-0.2475image
chr20:45895311-45896621:+LAMLCisplatinEER2.2586e-03-0.2475image
chr20:45895311-45896621:+LGGAZD6482EER2.7594e-030.1587image
ENSG00000064601.15,CTSALGGAZD6482EAG2.7296e-030.1586image
chr20:45895311-45896621:+LUADCCT018159EER1.3986e-02-0.1598image
ENSG00000064601.15,CTSALUADCCT018159EAG1.3957e-02-0.1598image
chr20:45895311-45896621:+LUSCCGP.082996EER1.2272e-020.1828image
ENSG00000064601.15,CTSALUSCCGP.082996EAG1.2272e-020.1828image
chr20:45895311-45896621:+OVAP.24534EER1.6748e-090.3620image
ENSG00000064601.15,CTSAOVAP.24534EAG1.6116e-090.3624image
ENSG00000064601.15,CTSAPRADAZD.2281EAG4.1641e-03-0.5632image
chr20:45895311-45896621:+PRADAZD.2281EER4.1641e-03-0.5632image
chr20:45895311-45896621:+READEmbelinEER4.2477e-04-0.4276image
ENSG00000064601.15,CTSAREADEmbelinEAG4.2477e-04-0.4276image
ENSG00000064601.15,CTSASARCMethotrexateEAG8.2727e-050.3797image
chr20:45895311-45896621:+SARCMethotrexateEER8.2727e-050.3797image
ENSG00000064601.15,CTSASKCMCEP.701EAG1.1300e-03-0.2048image
chr20:45895311-45896621:+SKCMCEP.701EER1.1300e-03-0.2048image
chr20:45895311-45896621:+STADBMS.509744EER1.7503e-08-0.3172image
ENSG00000064601.15,CTSASTADBMS.509744EAG5.0650e-09-0.3283image
ENSG00000064601.15,CTSATGCTBMS.509744EAG1.2244e-03-0.3510image
chr20:45895311-45896621:+TGCTBMS.509744EER1.2244e-03-0.3510image
ENSG00000064601.15,CTSATHCAAKT.inhibitor.VIIIEAG2.1211e-02-0.2156image
chr20:45895311-45896621:+THCAAKT.inhibitor.VIIIEER2.0100e-02-0.2175image
ENSG00000064601.15,CTSATHYMGSK269962AEAG2.0806e-040.5802image
chr20:45895311-45896621:+UCECAS601245EER1.5659e-020.4055image
ENSG00000064601.15,CTSAUCECAS601245EAG1.5659e-020.4055image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType