CAeditome Logo

Home

Download

Statistics

Landscape

Help

Contact
Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: MPHOSPH8 (ImmuneEditome ID:54737)

1. Gene summary of enriched editing regions for MPHOSPH8

check button Gene summary
Gene informationGene symbol

MPHOSPH8

Gene ID

54737

GeneSynonymsHSMPP8|TWA3|mpp8
GeneCytomap

13q12.11

GeneTypeprotein-coding
GeneDescriptionM-phase phosphoprotein 8|M-phase phosphoprotein, mpp|M-phase phosphoprotein, mpp8|two hybrid-associated protein 3 with RanBPM
GeneModificationdate20230517
UniprotIDQ99549
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr13:19659560-19660278:+ENST00000467481.1ENSG00000196199.12MPHOSPH8ncRNA_intronicAluYf1,AluJbchr13:19659560-19660278:+.alignment
chr13:19672369-19673039:+ENST00000361479.8ENSG00000196199.12MPHOSPH8UTR3AluSp,(A)n,AluJbchr13:19672369-19673039:+.alignment


Top

2. Tumor-specific enriched editing regions for MPHOSPH8


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
ENSG00000196199.12,MPHOSPH8BRCAEAG1.2125e-21image
chr13:19672369-19673039:+COADEER1.7030e-04image
ENSG00000196199.12,MPHOSPH8COADEAG1.3613e-04image
ENSG00000196199.12,MPHOSPH8HNSCEAG1.5013e-06image
ENSG00000196199.12,MPHOSPH8KICHEAG1.7643e-02image
chr13:19672369-19673039:+LUADEER5.2936e-09image
ENSG00000196199.12,MPHOSPH8LUADEAG6.3773e-09image
chr13:19672369-19673039:+LUSCEER2.7198e-09image
ENSG00000196199.12,MPHOSPH8LUSCEAG2.6904e-09image
ENSG00000196199.12,MPHOSPH8THCAEAG5.1259e-11image
ENSG00000196199.12,MPHOSPH8UCECEAG3.9317e-05image


Top

check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr13:19672369-19673039:+ESCACliEER3.6039e-041.5071e-02-0.3323image
ENSG00000196199.12,MPHOSPH8ESCACliEAG3.6838e-033.1086e-02-0.2965image
ENSG00000196199.12,MPHOSPH8KIRCPathEAG1.8620e-021.9434e-030.1344image
ENSG00000196199.12,MPHOSPH8THCAPathEAG1.1633e-041.4145e-030.1422image


Top

check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

Top

3. Enriched editing regions and immune related genes for MPHOSPH8


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr13:19672369-19673039:+LIHCEERENSG00000231683,RP1-27K12.20.23346.4007e-053.6082e-180.4294imageNNNAT_cells_CD4_naiveGSVA_HALLMARK_HEME_METABOLISM

More results



Top

4. Enriched editing regions and immune related splicing for MPHOSPH8


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000196199.12,MPHOSPH8
BLCAEAGIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.43021.9161e-145.0754e-18-0.4143imageNACIN1;ADAR;ALYREF;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YWHAG;ZNF184PRKCSHMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr13:19672369-19673039:+
ESCAEERIRENSG00000188283.7chr1937235548:37235675:37235978:372360740.30491.8060e-023.2415e-060.4026imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_PEROXISOME
ENSG00000196199.12,MPHOSPH8
UVMEAGIRENSG00000221968.4chr1161876358:61876455:61876865:61876871-0.49221.0308e-024.7000e-06-0.4895imageNACIN1;ADAR;ALYREF;AUH;BCCIP;BUD13;CELF2;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28;LIN28B;LSM11;MSI1;MSI2;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM22;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YWHAG;ZNF184NANK_cells_restingGSVA_HALLMARK_KRAS_SIGNALING_DN
ENSG00000196199.12,MPHOSPH8
UVMEAGIRENSG00000213339.4chr1910712160:10712299:10712552:10712628-0.45583.0461e-022.6726e-05-0.4537imageNACIN1;ADAR;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28;LIN28B;LSM11;MOV10;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YWHAG;ZNF184NAT_cells_follicular_helperGSVA_HALLMARK_KRAS_SIGNALING_DN
ENSG00000196199.12,MPHOSPH8
UVMEAGIRENSG00000140264.15chr1543792838:43793083:43793575:43794444-0.46802.4217e-022.5683e-04-0.4003imageNACIN1;ADAR;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YWHAG;ZNF184NANK_cells_restingGSVA_HALLMARK_KRAS_SIGNALING_DN
ENSG00000196199.12,MPHOSPH8
UVMEAGIRENSG00000165819.7chr1421498132:21499371:21499491:21499600-0.46032.8348e-021.5256e-05-0.4657imageNACIN1;ADAR;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YWHAG;ZNF184NANK_cells_restingGSVA_HALLMARK_KRAS_SIGNALING_DN
ENSG00000196199.12,MPHOSPH8
UVMEAGIRENSG00000077235.13chr1627463540:27463592:27464319:27464409-0.45572.8348e-026.9288e-05-0.4323imageNACIN1;ADAR;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RC3H1;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YWHAG;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000196199.12,MPHOSPH8
UVMEAGIRENSG00000113119.8chr5140644549:140644740:140644984:140645402-0.46562.4272e-022.2498e-05-0.4575imageNAUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_KRAS_SIGNALING_DN
ENSG00000196199.12,MPHOSPH8
UVMEAGIRENSG00000196998.11chrX49077073:49077747:49077836:49077911-0.47681.7063e-021.0016e-04-0.4236imageNACIN1;ADAR;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YWHAG;ZNF184NAMast_cells_activatedGSVA_HALLMARK_KRAS_SIGNALING_DN
ENSG00000196199.12,MPHOSPH8
UVMEAGIRENSG00000103253.13chr16729008:729088:729287:729715-0.46582.6699e-025.7830e-05-0.4365imageNACIN1;ADAR;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;DKC1;EIF4A3;EIF4G2;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28;LIN28B;LSM11;MSI1;MSI2;NOP56;NOP58;NUMA1;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YWHAG;ZNF184NAT_cells_follicular_helperGSVA_HALLMARK_KRAS_SIGNALING_DN

More results



Top

5. Enriched editing regions and immune infiltration for MPHOSPH8


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000196199.12,MPHOSPH8BLCAEAGT_cells_CD4_memory_activated6.7761e-120.3338image
ENSG00000196199.12,MPHOSPH8BRCAEAGT_cells_CD4_memory_activated6.9534e-050.1208image
chr13:19672369-19673039:+CESCEERB_cells_naive1.5710e-03-0.1806image
ENSG00000196199.12,MPHOSPH8CESCEAGB_cells_naive1.6814e-03-0.1794image
ENSG00000196199.12,MPHOSPH8CHOLEAGNK_cells_resting1.1475e-02-0.4224image
chr13:19672369-19673039:+COADEERDendritic_cells_activated4.4904e-050.2466image
ENSG00000196199.12,MPHOSPH8COADEAGDendritic_cells_activated5.9816e-050.2426image
ENSG00000196199.12,MPHOSPH8DLBCEAGMacrophages_M16.9976e-030.3924image
chr13:19672369-19673039:+ESCAEERT_cells_CD4_memory_activated4.8299e-030.2218image
ENSG00000196199.12,MPHOSPH8ESCAEAGT_cells_CD4_memory_activated6.6895e-030.2136image
ENSG00000196199.12,MPHOSPH8GBMEAGMacrophages_M13.3911e-030.2262image
ENSG00000196199.12,MPHOSPH8HNSCEAGNK_cells_resting1.8509e-030.1397image
ENSG00000196199.12,MPHOSPH8KICHEAGNK_cells_resting1.7967e-02-0.2927image
ENSG00000196199.12,MPHOSPH8KIRCEAGT_cells_gamma_delta1.0032e-030.1677image
ENSG00000196199.12,MPHOSPH8KIRPEAGT_cells_CD4_memory_activated7.8253e-030.1575image
ENSG00000196199.12,MPHOSPH8LGGEAGT_cells_CD4_naive6.0474e-05-0.1768image
chr13:19672369-19673039:+LUADEERMast_cells_resting2.3588e-03-0.1352image
ENSG00000196199.12,MPHOSPH8LUADEAGMast_cells_resting2.6452e-03-0.1336image
chr13:19672369-19673039:+LUSCEERMacrophages_M14.4800e-040.1573image
ENSG00000196199.12,MPHOSPH8LUSCEAGMacrophages_M14.5690e-040.1571image
chr13:19672369-19673039:+MESOEERT_cells_gamma_delta2.8481e-020.2420image
ENSG00000196199.12,MPHOSPH8MESOEAGT_cells_gamma_delta3.2892e-020.2359image
chr13:19672369-19673039:+OVEERDendritic_cells_resting9.3449e-030.1532image
ENSG00000196199.12,MPHOSPH8OVEAGDendritic_cells_resting3.3078e-020.1254image
chr13:19672369-19673039:+PAADEERNeutrophils7.4176e-030.2001image
ENSG00000196199.12,MPHOSPH8PAADEAGNeutrophils7.4176e-030.2001image
ENSG00000196199.12,MPHOSPH8PCPGEAGT_cells_regulatory_(Tregs)4.2162e-020.1504image
ENSG00000196199.12,MPHOSPH8PRADEAGMacrophages_M12.8331e-030.1338image
ENSG00000196199.12,MPHOSPH8READEAGT_cells_CD4_memory_activated5.3136e-03-0.2853image
chr13:19672369-19673039:+SARCEERNK_cells_resting3.1582e-02-0.1344image
ENSG00000196199.12,MPHOSPH8SARCEAGNK_cells_resting3.1587e-02-0.1344image
ENSG00000196199.12,MPHOSPH8SKCMEAGT_cells_CD82.1564e-050.1962image
ENSG00000196199.12,MPHOSPH8STADEAGB_cells_naive1.4213e-02-0.1277image
chr13:19672369-19673039:+TGCTEERMacrophages_M22.4388e-11-0.5107image
ENSG00000196199.12,MPHOSPH8TGCTEAGMacrophages_M22.4388e-11-0.5107image
ENSG00000196199.12,MPHOSPH8THCAEAGMacrophages_M24.9607e-06-0.2022image
chr13:19672369-19673039:+THYMEERT_cells_regulatory_(Tregs)3.5860e-07-0.4482image
ENSG00000196199.12,MPHOSPH8THYMEAGT_cells_regulatory_(Tregs)3.5860e-07-0.4482image
ENSG00000196199.12,MPHOSPH8UCECEAGDendritic_cells_activated2.3517e-030.2292image
ENSG00000196199.12,MPHOSPH8UCSEAGMacrophages_M02.0533e-020.3117image
ENSG00000196199.12,MPHOSPH8UVMEAGT_cells_CD4_memory_resting4.6513e-03-0.3153image


Top

6. Enriched editing regions and immune gene sets for MPHOSPH8


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


Top

check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000196199.12,MPHOSPH8BLCAEAG1.6610e-070.25773.2081e-060.23029.1582e-070.24221.4736e-060.2377image
chr13:19672369-19673039:+LUADEER3.0494e-090.26024.0897e-080.24148.7580e-090.25271.8637e-040.1657image
ENSG00000196199.12,MPHOSPH8LUADEAG4.1719e-090.25804.0812e-080.24141.3693e-080.24952.2004e-040.1639image
chr13:19672369-19673039:+OVEER6.3918e-040.20041.0499e-020.15089.9735e-030.15194.2047e-020.1201image
chr13:19672369-19673039:+PAADEER3.5896e-040.26461.0341e-030.24398.2501e-040.24857.4388e-090.4164image
ENSG00000196199.12,MPHOSPH8PAADEAG3.5896e-040.26461.0341e-030.24398.2501e-040.24857.4388e-090.4164image
ENSG00000196199.12,MPHOSPH8UCSEAG1.1764e-020.33741.4195e-030.41988.0736e-030.35377.8859e-030.3547image


Top

check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr13:19672369-19673039:+ACCGSVA_HALLMARK_NOTCH_SIGNALINGEER2.6572e-02-0.2511image
ENSG00000196199.12,MPHOSPH8ACCGSVA_HALLMARK_NOTCH_SIGNALINGEAG2.6220e-02-0.2517image
ENSG00000196199.12,MPHOSPH8BLCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG7.3697e-130.3480image
ENSG00000196199.12,MPHOSPH8BRCAGSVA_HALLMARK_GLYCOLYSISEAG2.7231e-120.2107image
ENSG00000196199.12,MPHOSPH8CESCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG7.8871e-070.2787image
chr13:19672369-19673039:+CESCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER7.8448e-070.2788image
ENSG00000196199.12,MPHOSPH8CHOLGSVA_HALLMARK_MTORC1_SIGNALINGEAG2.5638e-020.3769image
ENSG00000196199.12,MPHOSPH8COADGSVA_HALLMARK_SPERMATOGENESISEAG2.8742e-04-0.2198image
chr13:19672369-19673039:+COADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER7.3945e-040.2049image
ENSG00000196199.12,MPHOSPH8DLBCGSVA_HALLMARK_HYPOXIAEAG2.4489e-030.4361image
ENSG00000196199.12,MPHOSPH8ESCAGSVA_HALLMARK_BILE_ACID_METABOLISMEAG2.3713e-02-0.1788image
chr13:19672369-19673039:+ESCAGSVA_HALLMARK_BILE_ACID_METABOLISMEER2.1944e-02-0.1811image
ENSG00000196199.12,MPHOSPH8GBMGSVA_HALLMARK_BILE_ACID_METABOLISMEAG8.6506e-050.2999image
ENSG00000196199.12,MPHOSPH8HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG7.0583e-070.2210image
ENSG00000196199.12,MPHOSPH8KICHGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG4.7289e-020.2470image
ENSG00000196199.12,MPHOSPH8KIRCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG7.1315e-070.2504image
ENSG00000196199.12,MPHOSPH8KIRPGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG9.1712e-040.1957image
ENSG00000196199.12,MPHOSPH8LAMLGSVA_HALLMARK_HEME_METABOLISMEAG2.9391e-02-0.1919image
ENSG00000196199.12,MPHOSPH8LGGGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG5.6802e-090.2546image
ENSG00000196199.12,MPHOSPH8LIHCGSVA_HALLMARK_ADIPOGENESISEAG6.4790e-040.1758image
chr13:19672369-19673039:+LIHCGSVA_HALLMARK_ADIPOGENESISEER7.9944e-040.1729image
ENSG00000196199.12,MPHOSPH8LUADGSVA_HALLMARK_GLYCOLYSISEAG6.8212e-100.2704image
chr13:19672369-19673039:+LUADGSVA_HALLMARK_GLYCOLYSISEER5.4589e-100.2719image
chr13:19672369-19673039:+LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER6.4446e-080.2403image
ENSG00000196199.12,MPHOSPH8LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG8.0947e-080.2385image
chr13:19672369-19673039:+MESOGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.0334e-020.2818image
ENSG00000196199.12,MPHOSPH8MESOGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.1649e-020.2773image
ENSG00000196199.12,MPHOSPH8OVGSVA_HALLMARK_UV_RESPONSE_UPEAG2.1185e-050.2473image
chr13:19672369-19673039:+OVGSVA_HALLMARK_UV_RESPONSE_UPEER1.2611e-060.2815image
chr13:19672369-19673039:+PAADGSVA_HALLMARK_HYPOXIAEER7.4388e-090.4164image
ENSG00000196199.12,MPHOSPH8PAADGSVA_HALLMARK_HYPOXIAEAG7.4388e-090.4164image
ENSG00000196199.12,MPHOSPH8PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.6956e-050.3000image
ENSG00000196199.12,MPHOSPH8PRADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.1398e-040.1655image
ENSG00000196199.12,MPHOSPH8READGSVA_HALLMARK_MTORC1_SIGNALINGEAG4.1575e-04-0.3568image
chr13:19672369-19673039:+SARCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER6.1449e-05-0.2478image
ENSG00000196199.12,MPHOSPH8SARCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG5.6010e-05-0.2490image
ENSG00000196199.12,MPHOSPH8SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.0806e-060.2151image
ENSG00000196199.12,MPHOSPH8STADGSVA_HALLMARK_GLYCOLYSISEAG5.6832e-040.1788image
ENSG00000196199.12,MPHOSPH8TGCTGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG5.2356e-07-0.3961image
chr13:19672369-19673039:+TGCTGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER5.2356e-07-0.3961image
ENSG00000196199.12,MPHOSPH8THCAGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG5.7363e-160.3506image
ENSG00000196199.12,MPHOSPH8THYMGSVA_HALLMARK_G2M_CHECKPOINTEAG1.0511e-09-0.5249image
chr13:19672369-19673039:+THYMGSVA_HALLMARK_G2M_CHECKPOINTEER1.0511e-09-0.5249image
ENSG00000196199.12,MPHOSPH8UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG7.0228e-050.2967image
ENSG00000196199.12,MPHOSPH8UCSGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG1.0434e-030.4302image
ENSG00000196199.12,MPHOSPH8UVMGSVA_HALLMARK_COAGULATIONEAG2.6486e-050.4539image


Top

7. Enriched editing regions and drugs for MPHOSPH8


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr13:19672369-19673039:+ACCBleomycinEER1.9868e-030.3449image
ENSG00000196199.12,MPHOSPH8ACCBleomycinEAG1.9266e-030.3458image
ENSG00000196199.12,MPHOSPH8BLCACisplatinEAG2.3374e-09-0.2926image
ENSG00000196199.12,MPHOSPH8BRCAAMG.706EAG4.3393e-070.1531image
ENSG00000196199.12,MPHOSPH8CESCErlotinibEAG1.2845e-03-0.1838image
chr13:19672369-19673039:+CESCErlotinibEER1.4004e-03-0.1824image
ENSG00000196199.12,MPHOSPH8CHOLCMKEAG1.8055e-02-0.3975image
ENSG00000196199.12,MPHOSPH8COADJNJ.26854165EAG6.0265e-04-0.2082image
chr13:19672369-19673039:+COADJNJ.26854165EER1.1428e-03-0.1977image
ENSG00000196199.12,MPHOSPH8DLBCDoxorubicinEAG4.3236e-030.4131image
ENSG00000196199.12,MPHOSPH8ESCAGefitinibEAG2.7443e-02-0.1749image
chr13:19672369-19673039:+ESCACGP.60474EER1.9478e-03-0.2431image
ENSG00000196199.12,MPHOSPH8GBMKU.55933EAG1.3468e-05-0.3308image
ENSG00000196199.12,MPHOSPH8HNSCErlotinibEAG4.9099e-06-0.2043image
ENSG00000196199.12,MPHOSPH8KICHLenalidomideEAG4.5424e-03-0.3477image
ENSG00000196199.12,MPHOSPH8KIRCCisplatinEAG5.1739e-07-0.2535image
ENSG00000196199.12,MPHOSPH8KIRPGNF.2EAG1.1704e-05-0.2568image
ENSG00000196199.12,MPHOSPH8LAMLAZD6482EAG6.5108e-030.2384image
ENSG00000196199.12,MPHOSPH8LGGKU.55933EAG3.1634e-07-0.2245image
ENSG00000196199.12,MPHOSPH8LIHCGSK.650394EAG4.7630e-050.2090image
chr13:19672369-19673039:+LIHCGSK.650394EER6.0457e-050.2061image
ENSG00000196199.12,MPHOSPH8LUADCMKEAG4.7943e-06-0.2021image
chr13:19672369-19673039:+LUADCMKEER4.2729e-06-0.2032image
chr13:19672369-19673039:+LUSCBortezomibEER5.2856e-05-0.1808image
ENSG00000196199.12,MPHOSPH8LUSCBortezomibEAG5.1848e-05-0.1810image
chr13:19672369-19673039:+MESOGefitinibEER3.8098e-04-0.3832image
ENSG00000196199.12,MPHOSPH8MESOGefitinibEAG4.6756e-04-0.3777image
ENSG00000196199.12,MPHOSPH8OVAG.014699EAG4.8081e-040.2041image
chr13:19672369-19673039:+OVAG.014699EER1.4700e-040.2222image
chr13:19672369-19673039:+PAADBexaroteneEER4.3580e-03-0.2127image
ENSG00000196199.12,MPHOSPH8PAADBexaroteneEAG4.3580e-03-0.2127image
ENSG00000196199.12,MPHOSPH8PCPGAG.014699EAG4.4372e-030.2094image
ENSG00000196199.12,MPHOSPH8PRADAxitinibEAG5.1001e-030.1256image
ENSG00000196199.12,MPHOSPH8READBryostatin.1EAG3.3463e-04-0.3622image
chr13:19672369-19673039:+SARCCGP.60474EER1.8495e-04-0.2316image
ENSG00000196199.12,MPHOSPH8SARCCGP.60474EAG1.7264e-04-0.2327image
ENSG00000196199.12,MPHOSPH8SKCMAG.014699EAG1.0379e-070.2447image
ENSG00000196199.12,MPHOSPH8STADBX.795EAG4.7271e-020.1035image
ENSG00000196199.12,MPHOSPH8TGCTBMS.754807EAG4.0774e-060.3661image
chr13:19672369-19673039:+TGCTBMS.754807EER4.0774e-060.3661image
ENSG00000196199.12,MPHOSPH8THCABIBW2992EAG6.5744e-12-0.3001image
ENSG00000196199.12,MPHOSPH8THYMABT.263EAG4.3615e-140.6241image
chr13:19672369-19673039:+THYMABT.263EER4.3615e-140.6241image
ENSG00000196199.12,MPHOSPH8UCECAxitinibEAG2.8120e-030.2252image
ENSG00000196199.12,MPHOSPH8UCSBortezomibEAG1.7929e-04-0.4843image
ENSG00000196199.12,MPHOSPH8UVMCGP.60474EAG4.1508e-07-0.5334image


Top

check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType