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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: DDX56 (ImmuneEditome ID:54606)

1. Gene summary of enriched editing regions for DDX56

check button Gene summary
Gene informationGene symbol

DDX56

Gene ID

54606

GeneSynonymsDDX21|DDX26|NOH61
GeneCytomap

7p13

GeneTypeprotein-coding
GeneDescriptionprobable ATP-dependent RNA helicase DDX56|61-kd nucleolar helicase|ATP-dependent 61 kDa nucleolar RNA helicase|DEAD (Asp-Glu-Ala-Asp) box helicase 56|DEAD (Asp-Glu-Ala-Asp) box polypeptide 56|DEAD box protein 21|DEAD box protein 56|DEAD-box RNA helicase|nucleolar helicase of 61 kDa|putative nucleolar RNA helicase
GeneModificationdate20230329
UniprotIDQ9NY93;G3V0G3;H7BZN7;F8WDT8;F8WEI3
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr7:44574635-44574977:-ENST00000421223.4ENSG00000136271.9DDX56UTR5AluJochr7:44574635-44574977:-.alignment


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2. Tumor-specific enriched editing regions for DDX56


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000136271.9,DDX56HNSCCliEAG1.0856e-025.5607e-03-0.4653image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
ENSG00000136271.9,DDX56HNSCEAG8.6678e-041.9691e-023.9337e+03image
chr7:44574635-44574977:-MESOEER3.7023e-023.2907e-026.0062e-02image
ENSG00000136271.9,DDX56MESOEAG3.1322e-024.0875e-024.8699e-02image

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3. Enriched editing regions and immune related genes for DDX56


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr7:44574635-44574977:-ESCAEERENSG00000213793,ZNF888-0.46631.1601e-043.6103e-06-0.4039imageNNOP56NAB_cells_naiveGSVA_HALLMARK_HYPOXIA
chr7:44574635-44574977:-ESCAEERENSG00000143891,GALM-0.46221.5174e-042.9364e-06-0.4073imageNFXR1;NOP56NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr7:44574635-44574977:-ESCAEERENSG00000108465,CDK5RAP3-0.43923.1560e-044.2695e-06-0.4011imageNFXR1;NOP56NAB_cells_naiveGSVA_HALLMARK_HYPOXIA
chr7:44574635-44574977:-ESCAEERENSG00000135637,CCDC142-0.43875.4749e-042.9695e-06-0.4071imageNFXR1;NOP56NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr7:44574635-44574977:-ESCAEERENSG00000101391,CDK5RAP1-0.39662.5456e-034.1157e-06-0.4017imageNFXR1;NOP56NADendritic_cells_restingGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr7:44574635-44574977:-ESCAEERENSG00000178184,PARD6G0.38603.0157e-033.2701e-060.4055imageNNOP56NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_KRAS_SIGNALING_DN
chr7:44574635-44574977:-ESCAEERENSG00000139668,WDFY20.38004.1272e-039.3548e-070.4254imageNNOP56NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_KRAS_SIGNALING_DN
chr7:44574635-44574977:-ESCAEERENSG00000171314,PGAM10.36396.1130e-031.5106e-060.4179imageNFXR1;NOP56PGAM1T_cells_CD4_memory_restingGSVA_HALLMARK_P53_PATHWAY
chr7:44574635-44574977:-ESCAEERENSG00000137094,DNAJB50.36538.0734e-032.3101e-070.4462imageNNNAMonocytesGSVA_HALLMARK_MYOGENESIS
chr7:44574635-44574977:-ESCAEERENSG00000177614,PGBD50.34151.3206e-021.8982e-080.4802imageNNOP56NAMonocytesGSVA_HALLMARK_HEDGEHOG_SIGNALING

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4. Enriched editing regions and immune related splicing for DDX56


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000136271.9,DDX56
ESCAEAGESENSG00000138443.11chr2203402705:203402734:203411284:203411371:203416907:203416972-0.36933.1267e-028.9861e-07-0.4244imageNACIN1;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM5;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;YTHDC1;YTHDF1;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr7:44574635-44574977:-
ESCAEERESENSG00000054654.11chr1464214193:64214470:64215285:64215354:64216247:642163870.36801.5950e-023.3380e-060.4052imageNFXR1;NOP56NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_KRAS_SIGNALING_DN
chr7:44574635-44574977:-
ESCAEERIRENSG00000130827.5chrX154458280:154458428:154460156:154460777-0.36491.6517e-023.7300e-06-0.4341imageNFXR1PLXNA3T_cells_CD4_memory_restingGSVA_HALLMARK_KRAS_SIGNALING_DN
chr7:44574635-44574977:-
ESCAEERIRENSG00000138834.8chr161743334:1743476:1747028:1747067-0.43403.1408e-033.1608e-07-0.4433imageNFXR1;NOP56MAPK8IP3Dendritic_cells_restingGSVA_HALLMARK_P53_PATHWAY
ENSG00000136271.9,DDX56
ESCAEAGIRENSG00000130827.5chrX154458280:154458428:154460156:154460777-0.34123.9612e-021.3943e-05-0.4083imageNACIN1;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184PLXNA3T_cells_CD4_memory_restingGSVA_HALLMARK_KRAS_SIGNALING_DN
chr7:44574635-44574977:-
ESCAEERA5ENSG00000054654.11chr1464216247:64216387:64214143:64214470:64214143:64215354-0.36381.6781e-023.7061e-06-0.4035imageNFXR1;NOP56NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_KRAS_SIGNALING_DN
ENSG00000136271.9,DDX56
ESCAEAGMEXENSG00000054654.11chr1464214193:64214470:64216247:64216424:64218397:64218512:64219207:64219410-0.35174.0086e-022.2889e-06-0.4098imageNACIN1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;LIN28;LIN28A;LIN28B;MOV10;MSI1;NCBP3;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM5;RNF219;RTCB;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;YTHDC1;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_KRAS_SIGNALING_DN
chr7:44574635-44574977:-
ESCAEERMEXENSG00000026508.12chr1135190009:35190065:35198144:35198246:35208104:35210054:35214851:352149140.37962.0909e-026.2901e-070.4331imageNFXR1;NOP56CD44Dendritic_cells_restingGSVA_HALLMARK_PANCREAS_BETA_CELLS
ENSG00000136271.9,DDX56
ESCAEAGA5ENSG00000138834.8chr161747028:1747067:1743334:1743476:1743334:17451030.43593.6164e-038.1805e-070.4259imageNACIN1;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM5;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDF1;YWHAG;ZNF184MAPK8IP3Dendritic_cells_restingGSVA_HALLMARK_KRAS_SIGNALING_DN
chr7:44574635-44574977:-
ESCAEERESENSG00000026508.12chr1135209969:35210054:35211263:35211449:35214851:352148610.35473.0129e-023.2671e-060.4134imageNFXR1;NOP56CD44B_cells_naiveGSVA_HALLMARK_PANCREAS_BETA_CELLS

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5. Enriched editing regions and immune infiltration for DDX56


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr7:44574635-44574977:-BLCAEEREosinophils4.8559e-030.2655image
ENSG00000136271.9,DDX56BLCAEAGEosinophils6.0261e-030.2536image
chr7:44574635-44574977:-BRCAEERT_cells_gamma_delta2.6282e-020.1277image
chr7:44574635-44574977:-CESCEERMacrophages_M13.4520e-020.2324image
ENSG00000136271.9,DDX56CESCEAGMacrophages_M13.7518e-020.2288image
chr7:44574635-44574977:-ESCAEERDendritic_cells_resting2.3514e-030.2719image
ENSG00000136271.9,DDX56ESCAEAGEosinophils2.9068e-030.2653image
ENSG00000136271.9,DDX56HNSCEAGT_cells_follicular_helper3.1597e-020.3640image
ENSG00000136271.9,DDX56KICHEAGB_cells_naive2.5714e-02-0.3714image
chr7:44574635-44574977:-KIRCEERDendritic_cells_activated4.7273e-020.1457image
ENSG00000136271.9,DDX56KIRCEAGDendritic_cells_activated4.4014e-020.1475image
chr7:44574635-44574977:-KIRPEERT_cells_CD4_naive1.1420e-020.2054image
ENSG00000136271.9,DDX56KIRPEAGT_cells_CD4_naive8.3504e-030.2112image
ENSG00000136271.9,DDX56LAMLEAGT_cells_gamma_delta2.6601e-020.2008image
chr7:44574635-44574977:-LGGEERT_cells_CD4_memory_resting5.2142e-03-0.1578image
ENSG00000136271.9,DDX56LGGEAGDendritic_cells_resting1.3303e-020.1394image
chr7:44574635-44574977:-LUADEERMast_cells_activated2.3799e-020.1699image
ENSG00000136271.9,DDX56LUADEAGMast_cells_activated1.9270e-020.1753image
chr7:44574635-44574977:-LUSCEERT_cells_CD4_memory_activated3.9218e-02-0.1680image
chr7:44574635-44574977:-OVEERT_cells_follicular_helper1.1540e-020.1962image
ENSG00000136271.9,DDX56OVEAGT_cells_follicular_helper2.0132e-020.1808image
chr7:44574635-44574977:-PAADEERMacrophages_M02.4807e-020.3141image
ENSG00000136271.9,DDX56PAADEAGMacrophages_M02.5732e-020.3062image
chr7:44574635-44574977:-PCPGEERNK_cells_activated4.4288e-020.2284image
ENSG00000136271.9,DDX56PCPGEAGEosinophils2.9123e-020.2382image
chr7:44574635-44574977:-SKCMEERNK_cells_activated3.5656e-03-0.3241image
ENSG00000136271.9,DDX56SKCMEAGNK_cells_activated4.7332e-03-0.3147image
chr7:44574635-44574977:-TGCTEERT_cells_CD82.0955e-03-0.3118image
ENSG00000136271.9,DDX56TGCTEAGT_cells_follicular_helper9.6228e-04-0.3300image
chr7:44574635-44574977:-UCECEERNK_cells_activated7.1442e-030.3588image
ENSG00000136271.9,DDX56UCECEAGNK_cells_activated3.9699e-020.2733image


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6. Enriched editing regions and immune gene sets for DDX56


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000136271.9,DDX56BRCAEAG1.3872e-020.13961.9350e-020.13281.6918e-020.13564.5021e-020.1139image
chr7:44574635-44574977:-BRCAEER1.1567e-020.14492.2353e-020.13122.2150e-020.13142.9507e-020.1251image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr7:44574635-44574977:-BLCAGSVA_HALLMARK_HYPOXIAEER8.8140e-030.2475image
ENSG00000136271.9,DDX56BLCAGSVA_HALLMARK_HYPOXIAEAG1.5988e-020.2233image
ENSG00000136271.9,DDX56BRCAGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG1.1328e-030.1840image
chr7:44574635-44574977:-BRCAGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER1.5129e-030.1815image
ENSG00000136271.9,DDX56COADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG5.5009e-030.3485image
chr7:44574635-44574977:-COADGSVA_HALLMARK_TGF_BETA_SIGNALINGEER1.6450e-02-0.3036image
chr7:44574635-44574977:-ESCAGSVA_HALLMARK_HYPOXIAEER9.6280e-050.3443image
ENSG00000136271.9,DDX56ESCAGSVA_HALLMARK_HYPOXIAEAG7.7375e-050.3473image
ENSG00000136271.9,DDX56GBMGSVA_HALLMARK_PROTEIN_SECRETIONEAG7.2571e-040.3161image
chr7:44574635-44574977:-GBMGSVA_HALLMARK_PROTEIN_SECRETIONEER6.2988e-040.3195image
ENSG00000136271.9,DDX56HNSCGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.6542e-020.4024image
ENSG00000136271.9,DDX56KICHGSVA_HALLMARK_NOTCH_SIGNALINGEAG3.5958e-02-0.3508image
ENSG00000136271.9,DDX56KIRCGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG7.4593e-040.2445image
chr7:44574635-44574977:-KIRCGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER1.2991e-040.2769image
chr7:44574635-44574977:-KIRPGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEER2.8727e-020.1781image
ENSG00000136271.9,DDX56KIRPGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG2.0584e-020.1859image
ENSG00000136271.9,DDX56LAMLGSVA_HALLMARK_COAGULATIONEAG4.7578e-02-0.1797image
chr7:44574635-44574977:-LGGGSVA_HALLMARK_ANGIOGENESISEER2.5276e-02-0.1267image
ENSG00000136271.9,DDX56LGGGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG1.4550e-020.1376image
chr7:44574635-44574977:-LUSCGSVA_HALLMARK_ADIPOGENESISEER1.0226e-030.2647image
ENSG00000136271.9,DDX56LUSCGSVA_HALLMARK_ADIPOGENESISEAG3.2736e-040.2885image
chr7:44574635-44574977:-MESOGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.1289e-020.4233image
ENSG00000136271.9,DDX56MESOGSVA_HALLMARK_KRAS_SIGNALING_UPEAG3.3601e-020.3601image
ENSG00000136271.9,DDX56OVGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG4.3564e-020.1573image
ENSG00000136271.9,DDX56PAADGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG9.5244e-040.4409image
chr7:44574635-44574977:-PAADGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER7.4521e-040.4572image
chr7:44574635-44574977:-PCPGGSVA_HALLMARK_NOTCH_SIGNALINGEER8.7930e-030.2948image
ENSG00000136271.9,DDX56PCPGGSVA_HALLMARK_NOTCH_SIGNALINGEAG1.7123e-020.2595image
ENSG00000136271.9,DDX56PRADGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG3.5954e-020.1455image
ENSG00000136271.9,DDX56SARCGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.5176e-020.2872image
ENSG00000136271.9,DDX56SKCMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.2554e-020.2797image
chr7:44574635-44574977:-SKCMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.0477e-020.2604image
ENSG00000136271.9,DDX56STADGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG1.4910e-020.1703image
chr7:44574635-44574977:-STADGSVA_HALLMARK_APOPTOSISEER1.4530e-020.1709image
ENSG00000136271.9,DDX56TGCTGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG6.9338e-050.3927image
chr7:44574635-44574977:-TGCTGSVA_HALLMARK_TGF_BETA_SIGNALINGEER2.9246e-040.3636image
ENSG00000136271.9,DDX56THCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG1.5829e-030.2142image
chr7:44574635-44574977:-THCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER1.9658e-030.2109image


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7. Enriched editing regions and drugs for DDX56


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr7:44574635-44574977:-ACCBMS.754807EER1.2636e-020.4573image
ENSG00000136271.9,DDX56ACCAZD7762EAG1.0048e-020.4554image
chr7:44574635-44574977:-BLCALFM.A13EER2.8394e-03-0.2807image
ENSG00000136271.9,DDX56BLCALFM.A13EAG2.8552e-03-0.2746image
ENSG00000136271.9,DDX56BRCABI.D1870EAG1.6944e-03-0.1776image
chr7:44574635-44574977:-BRCABI.D1870EER1.3639e-03-0.1832image
ENSG00000136271.9,DDX56CESCBIBW2992EAG1.9202e-03-0.3357image
chr7:44574635-44574977:-CESCBIBW2992EER2.0459e-03-0.3338image
ENSG00000136271.9,DDX56COADAZD6482EAG4.2879e-030.3579image
chr7:44574635-44574977:-COADJNK.Inhibitor.VIIIEER1.3533e-020.3121image
chr7:44574635-44574977:-ESCAErlotinibEER1.1555e-04-0.3406image
ENSG00000136271.9,DDX56ESCAErlotinibEAG1.7934e-04-0.3303image
ENSG00000136271.9,DDX56GBMMG.132EAG3.8494e-03-0.2722image
chr7:44574635-44574977:-GBMMG.132EER3.7318e-03-0.2731image
ENSG00000136271.9,DDX56HNSCBosutinibEAG1.2122e-02-0.4195image
ENSG00000136271.9,DDX56KICHBI.2536EAG4.3272e-030.4644image
ENSG00000136271.9,DDX56KIRCAKT.inhibitor.VIIIEAG5.5007e-04-0.2503image
chr7:44574635-44574977:-KIRCAKT.inhibitor.VIIIEER7.0765e-04-0.2461image
chr7:44574635-44574977:-KIRPAICAREER1.6256e-02-0.1953image
ENSG00000136271.9,DDX56KIRPAICAREAG2.9764e-02-0.1746image
ENSG00000136271.9,DDX56LAMLBryostatin.1EAG1.9824e-020.2107image
chr7:44574635-44574977:-LGGEmbelinEER4.5763e-030.1601image
ENSG00000136271.9,DDX56LGGBX.795EAG3.8056e-030.1626image
chr7:44574635-44574977:-LUSCLFM.A13EER2.0275e-03-0.2492image
ENSG00000136271.9,DDX56LUSCBIRB.0796EAG9.7300e-040.2658image
chr7:44574635-44574977:-MESOJW.7.52.1EER1.0798e-03-0.5292image
ENSG00000136271.9,DDX56MESOKU.55933EAG3.1268e-04-0.5739image
chr7:44574635-44574977:-OVBleomycinEER3.1114e-03-0.2288image
ENSG00000136271.9,DDX56OVBleomycinEAG2.8637e-03-0.2308image
ENSG00000136271.9,DDX56PAADBMS.754807EAG2.0304e-02-0.3242image
chr7:44574635-44574977:-PAADBMS.754807EER2.3681e-02-0.3228image
chr7:44574635-44574977:-PCPGBMS.754807EER9.1088e-04-0.3682image
ENSG00000136271.9,DDX56PCPGBAY.61.3606EAG4.0657e-04-0.3771image
ENSG00000136271.9,DDX56SARCGDC0941EAG1.0071e-020.3036image
chr7:44574635-44574977:-SARCGDC0941EER2.6946e-020.2645image
ENSG00000136271.9,DDX56SKCMBX.795EAG8.5416e-030.2940image
chr7:44574635-44574977:-SKCMBX.795EER1.8184e-020.2652image
ENSG00000136271.9,DDX56STADAZ628EAG4.7472e-02-0.1390image
chr7:44574635-44574977:-STADAZ628EER4.9505e-02-0.1377image
ENSG00000136271.9,DDX56TGCTAZD8055EAG3.2966e-040.3571image
chr7:44574635-44574977:-TGCTAZD8055EER8.5161e-040.3366image
chr7:44574635-44574977:-THCACGP.082996EER3.2794e-03-0.2006image
ENSG00000136271.9,DDX56THCABMS.708163EAG3.0786e-03-0.2010image
chr7:44574635-44574977:-UCECEpothilone.BEER5.8820e-04-0.4488image
ENSG00000136271.9,DDX56UCECEpothilone.BEAG4.0470e-04-0.4528image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType