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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: C21orf58 (ImmuneEditome ID:54058)

1. Gene summary of enriched editing regions for C21orf58

check button Gene summary
Gene informationGene symbol

C21orf58

Gene ID

54058

GeneSynonyms-
GeneCytomap

21q22.3

GeneTypeprotein-coding
GeneDescriptionuncharacterized protein C21orf58
GeneModificationdate20230517
UniprotIDP58505;C9JH41;H7C1T9;H0YCB6
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr21:46319469-46319863:-ENST00000475776.1ENSG00000160298.16C21orf58ncRNA_intronicAluSq4,AluJrchr21:46319469-46319863:-.alignment
chr21:46320334-46322305:-ENST00000475776.1ENSG00000160298.16C21orf58ncRNA_intronicAluJo,L1MC3,AluJb,AluSx4,AluSz,Charlie15b,LTR62,AluSqchr21:46320334-46322305:-.alignment


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2. Tumor-specific enriched editing regions for C21orf58


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
ENSG00000160298.16,C21orf58BRCAEAG2.8804e-041.7292e-021.2233e-02image

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3. Enriched editing regions and immune related genes for C21orf58


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for C21orf58


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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5. Enriched editing regions and immune infiltration for C21orf58


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr21:46320334-46322305:-BLCAEERMast_cells_resting9.3061e-030.2375image
chr21:46320334-46322305:-BRCAEERT_cells_follicular_helper7.5667e-03-0.1144image
ENSG00000160298.16,C21orf58BRCAEAGT_cells_follicular_helper3.2528e-03-0.1216image
chr21:46320334-46322305:-CESCEERB_cells_naive1.8855e-02-0.2141image
ENSG00000160298.16,C21orf58CESCEAGMacrophages_M08.5986e-030.2305image
ENSG00000160298.16,C21orf58COADEAGNeutrophils7.3803e-060.7680image
chr21:46320334-46322305:-ESCAEERMast_cells_activated1.8535e-020.2387image
ENSG00000160298.16,C21orf58ESCAEAGMast_cells_activated4.7418e-040.3383image
ENSG00000160298.16,C21orf58HNSCEAGNK_cells_resting2.6637e-020.2363image
ENSG00000160298.16,C21orf58LGGEAGT_cells_CD4_memory_resting4.2342e-02-0.2943image
ENSG00000160298.16,C21orf58LUADEAGT_cells_CD4_memory_activated2.8570e-020.2224image
ENSG00000160298.16,C21orf58LUSCEAGMonocytes3.5291e-02-0.1820image
chr21:46320334-46322305:-OVEERT_cells_CD85.1940e-040.2432image
ENSG00000160298.16,C21orf58OVEAGT_cells_CD84.3518e-030.1942image
ENSG00000160298.16,C21orf58PCPGEAGT_cells_follicular_helper2.3494e-020.4428image
ENSG00000160298.16,C21orf58SKCMEAGNK_cells_activated1.3336e-020.2809image
ENSG00000160298.16,C21orf58STADEAGT_cells_regulatory_(Tregs)5.8298e-030.2319image
ENSG00000160298.16,C21orf58TGCTEAGMacrophages_M23.5329e-03-0.4011image
ENSG00000160298.16,C21orf58THYMEAGB_cells_memory1.7821e-020.4608image
chr21:46320334-46322305:-UCECEERNK_cells_activated7.1805e-040.4626image
ENSG00000160298.16,C21orf58UCECEAGDendritic_cells_activated3.7726e-020.2667image


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6. Enriched editing regions and immune gene sets for C21orf58


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr21:46320334-46322305:-BRCAEER4.1714e-06image1.9314e-030.1326image
ENSG00000160298.16,C21orf58BRCAEAG4.4597e-04image3.0859e-030.1222image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr21:46320334-46322305:-BRCAEER1.1591e-06-0.20671.0681e-10-0.27228.7907e-05-0.16733.5368e-020.0902image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000160298.16,C21orf58BLCAGSVA_HALLMARK_MYC_TARGETS_V1EAG6.2273e-04-0.2951image
chr21:46320334-46322305:-BLCAGSVA_HALLMARK_COAGULATIONEER3.5107e-040.3223image
ENSG00000160298.16,C21orf58BRCAGSVA_HALLMARK_E2F_TARGETSEAG1.8172e-09-0.2455image
chr21:46320334-46322305:-BRCAGSVA_HALLMARK_E2F_TARGETSEER2.3002e-11-0.2815image
ENSG00000160298.16,C21orf58CESCGSVA_HALLMARK_COAGULATIONEAG3.7994e-040.3082image
chr21:46320334-46322305:-CESCGSVA_HALLMARK_COAGULATIONEER1.2228e-040.3435image
ENSG00000160298.16,C21orf58COADGSVA_HALLMARK_DNA_REPAIREAG2.3498e-03-0.5805image
ENSG00000160298.16,C21orf58ESCAGSVA_HALLMARK_ANDROGEN_RESPONSEEAG3.2626e-020.2107image
ENSG00000160298.16,C21orf58HNSCGSVA_HALLMARK_GLYCOLYSISEAG4.9970e-060.4650image
ENSG00000160298.16,C21orf58LAMLGSVA_HALLMARK_P53_PATHWAYEAG8.1144e-030.3257image
ENSG00000160298.16,C21orf58LGGGSVA_HALLMARK_HEME_METABOLISMEAG5.9106e-030.3916image
ENSG00000160298.16,C21orf58LIHCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.3424e-020.3451image
ENSG00000160298.16,C21orf58LUADGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG1.4516e-020.2475image
chr21:46320334-46322305:-LUSCGSVA_HALLMARK_MITOTIC_SPINDLEEER1.5350e-03-0.2805image
ENSG00000160298.16,C21orf58LUSCGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG3.7517e-030.2488image
ENSG00000160298.16,C21orf58OVGSVA_HALLMARK_MITOTIC_SPINDLEEAG8.6869e-05-0.2650image
chr21:46319469-46319863:-OVGSVA_HALLMARK_ANDROGEN_RESPONSEEER1.8673e-020.4861image
chr21:46320334-46322305:-OVGSVA_HALLMARK_MITOTIC_SPINDLEEER5.9058e-05-0.2801image
ENSG00000160298.16,C21orf58PCPGGSVA_HALLMARK_SPERMATOGENESISEAG3.7278e-020.4104image
ENSG00000160298.16,C21orf58PRADGSVA_HALLMARK_BILE_ACID_METABOLISMEAG3.8933e-020.3199image
ENSG00000160298.16,C21orf58SKCMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG4.2580e-030.3223image
ENSG00000160298.16,C21orf58STADGSVA_HALLMARK_G2M_CHECKPOINTEAG3.1310e-04-0.3002image
ENSG00000160298.16,C21orf58TGCTGSVA_HALLMARK_ANGIOGENESISEAG2.6275e-02-0.3111image
ENSG00000160298.16,C21orf58THYMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.1777e-030.6006image
chr21:46320334-46322305:-UCECGSVA_HALLMARK_E2F_TARGETSEER5.7932e-06-0.5926image
ENSG00000160298.16,C21orf58UCECGSVA_HALLMARK_SPERMATOGENESISEAG2.1659e-05-0.5150image
ENSG00000160298.16,C21orf58UCSGSVA_HALLMARK_MTORC1_SIGNALINGEAG1.3226e-020.4269image


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7. Enriched editing regions and drugs for C21orf58


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000160298.16,C21orf58BLCALFM.A13EAG6.2225e-04-0.2951image
chr21:46320334-46322305:-BLCALFM.A13EER1.0877e-04-0.3473image
ENSG00000160298.16,C21orf58BRCALFM.A13EAG1.4412e-04-0.1566image
chr21:46320334-46322305:-BRCABryostatin.1EER1.5538e-08-0.2395image
ENSG00000160298.16,C21orf58CESCCI.1040EAG8.5843e-06-0.3807image
chr21:46320334-46322305:-CESCCI.1040EER7.7654e-06-0.3956image
ENSG00000160298.16,C21orf58COADGW843682XEAG4.0539e-070.8244image
ENSG00000160298.16,C21orf58ESCAAG.014699EAG1.9092e-030.3024image
chr21:46320334-46322305:-ESCAGDC0941EER5.1412e-030.2820image
ENSG00000160298.16,C21orf58HNSCFTI.277EAG8.7726e-04-0.3485image
ENSG00000160298.16,C21orf58LAMLLenalidomideEAG1.5412e-020.2994image
ENSG00000160298.16,C21orf58LGGAZD.2281EAG6.5563e-030.3872image
ENSG00000160298.16,C21orf58LIHCAS601245EAG6.1623e-03-0.4112image
ENSG00000160298.16,C21orf58LUADEmbelinEAG3.3859e-03-0.2947image
chr21:46320334-46322305:-LUSCBMS.536924EER5.9458e-04-0.3030image
ENSG00000160298.16,C21orf58LUSCBMS.536924EAG4.7729e-04-0.2977image
ENSG00000160298.16,C21orf58OVAZ628EAG3.9353e-06-0.3095image
chr21:46319469-46319863:-OVGDC.0449EER4.8276e-020.4161image
chr21:46320334-46322305:-OVBMS.509744EER2.3418e-06-0.3267image
ENSG00000160298.16,C21orf58PCPGGDC.0449EAG4.3415e-020.3991image
ENSG00000160298.16,C21orf58SARCA.443654EAG1.2090e-020.3050image
ENSG00000160298.16,C21orf58SKCMJW.7.52.1EAG2.7297e-03-0.3370image
ENSG00000160298.16,C21orf58STADBI.D1870EAG2.7491e-030.2513image
ENSG00000160298.16,C21orf58TGCTBMS.754807EAG9.3360e-040.4496image
ENSG00000160298.16,C21orf58THYMAZD.0530EAG2.7313e-06-0.7792image
chr21:46320334-46322305:-UCECBryostatin.1EER5.2503e-04-0.4729image
ENSG00000160298.16,C21orf58UCECBryostatin.1EAG4.1526e-04-0.4380image
ENSG00000160298.16,C21orf58UCSABT.263EAG1.8586e-030.5214image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType