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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: SLC25A3 (ImmuneEditome ID:5250)

1. Gene summary of enriched editing regions for SLC25A3

check button Gene summary
Gene informationGene symbol

SLC25A3

Gene ID

5250

GeneSynonymsOK/SW-cl.48|PHC|PTP|PiC
GeneCytomap

12q23.1

GeneTypeprotein-coding
GeneDescriptionphosphate carrier protein, mitochondrial|phosphate transport protein|solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
GeneModificationdate20230404
UniprotIDQ00325;A0A024RBE8;A0A024RBH9;F8VYH5;F8VVM2;F8VY00;F8VWR4;F8VWQ0
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr12:98596733-98597620:+ENST00000547444.1ENSG00000075415.11SLC25A3ncRNA_exonicAluSz,AluSx,MER44Achr12:98596733-98597620:+.alignment
chr12:98602195-98602441:+ENST00000401722.6ENSG00000075415.11SLC25A3UTR3AluSpchr12:98602195-98602441:+.alignment
chr12:98603931-98606118:+ENST00000401722.6ENSG00000075415.11SLC25A3UTR3AluSp,(TATTT)n,AluSz,(TA)n,AluJo,AluJbchr12:98603931-98606118:+.alignment


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2. Tumor-specific enriched editing regions for SLC25A3


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr12:98596733-98597620:+BRCAEER3.6278e-02image
chr12:98603931-98606118:+BRCAEER1.3558e-23image
ENSG00000075415.11,SLC25A3BRCAEAG7.3739e-24image
chr12:98603931-98606118:+COADEER3.5631e-14image
ENSG00000075415.11,SLC25A3COADEAG3.3224e-14image
chr12:98603931-98606118:+HNSCEER1.1943e-07image
ENSG00000075415.11,SLC25A3HNSCEAG2.4158e-08image
ENSG00000075415.11,SLC25A3KICHEAG1.4278e-02image
chr12:98603931-98606118:+KIRCEER1.4361e-05image
ENSG00000075415.11,SLC25A3KIRCEAG9.0915e-05image
chr12:98603931-98606118:+KIRPEER7.2929e-06image
ENSG00000075415.11,SLC25A3KIRPEAG5.2047e-05image
chr12:98603931-98606118:+LIHCEER1.3373e-02image
ENSG00000075415.11,SLC25A3LIHCEAG1.3555e-02image
chr12:98603931-98606118:+LUADEER1.6894e-03image
ENSG00000075415.11,SLC25A3LUADEAG3.6672e-03image
chr12:98603931-98606118:+LUSCEER1.7467e-18image
ENSG00000075415.11,SLC25A3LUSCEAG1.6737e-20image
chr12:98603931-98606118:+PRADEER1.9984e-02image
ENSG00000075415.11,SLC25A3PRADEAG2.7253e-02image
chr12:98603931-98606118:+UCECEER6.2722e-07image
ENSG00000075415.11,SLC25A3UCECEAG6.8507e-07image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr12:98603931-98606118:+KIRPPathEER9.8336e-039.3093e-040.2053image
ENSG00000075415.11,SLC25A3KIRPPathEAG1.9527e-021.9828e-030.1917image
chr12:98603931-98606118:+THCAPathEER5.4257e-042.5685e-030.1342image
ENSG00000075415.11,SLC25A3THCAPathEAG4.1072e-044.5902e-030.1262image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr12:98603931-98606118:+OVEER3.4879e-034.6222e-033.0779e+01image
ENSG00000075415.11,SLC25A3OVEAG5.0260e-031.5130e-036.8253e+01image

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3. Enriched editing regions and immune related genes for SLC25A3


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr12:98596733-98597620:+ESCAEERENSG00000207031,SNORD59A-0.43784.6403e-045.1313e-07-0.4297imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr12:98603931-98606118:+UCECEERENSG00000152457,DCLRE1C0.29991.4966e-021.3485e-150.5728imageNNDCLRE1CT_cells_follicular_helperGSVA_HALLMARK_PEROXISOME
chr12:98603931-98606118:+DLBCEERENSG00000151881,C5orf28-0.60422.3985e-025.2221e-03-0.4233imageNNNAB_cells_naiveGSVA_HALLMARK_MITOTIC_SPINDLE
chr12:98603931-98606118:+ESCAEERENSG00000278677,HIST1H2AM0.26043.8077e-021.1883e-070.4050imageNNNANK_cells_activatedGSVA_HALLMARK_E2F_TARGETS
chr12:98603931-98606118:+PAADEERENSG00000132746,ALDH3B20.31256.5609e-031.2971e-110.4867imageNNNAMacrophages_M0GSVA_HALLMARK_PANCREAS_BETA_CELLS
chr12:98603931-98606118:+UVMEERENSG00000199753,SNORD104-0.70155.4324e-068.2840e-08-0.5785imageNNNAT_cells_follicular_helperGSVA_HALLMARK_KRAS_SIGNALING_DN
chr12:98603931-98606118:+UVMEERENSG00000267481,CTC-559E9.5-0.68875.4324e-067.4921e-08-0.5801imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_KRAS_SIGNALING_DN
chr12:98603931-98606118:+UVMEERENSG00000198040,ZNF84-0.68625.4324e-062.0332e-08-0.5999imageNNNAMacrophages_M2GSVA_HALLMARK_KRAS_SIGNALING_DN
chr12:98603931-98606118:+UVMEERENSG00000243679,RP11-274B21.3-0.68625.4324e-067.3829e-07-0.5419imageNNNAT_cells_follicular_helperGSVA_HALLMARK_KRAS_SIGNALING_DN
chr12:98603931-98606118:+UVMEERENSG00000197961,ZNF121-0.68975.4324e-064.9192e-09-0.6200imageNNNAT_cells_follicular_helperGSVA_HALLMARK_KRAS_SIGNALING_DN
chr12:98603931-98606118:+UVMEERENSG00000105821,DNAJC2-0.68087.8593e-061.1466e-08-0.6082imageNNNAT_cells_follicular_helperGSVA_HALLMARK_KRAS_SIGNALING_DN

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4. Enriched editing regions and immune related splicing for SLC25A3


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000075415.11,SLC25A3
COADEAGMEXENSG00000131375.5chr315240508:15240617:15240753:15240853:15245525:15245671:15246731:152467940.22783.6774e-024.1921e-120.4089imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL3;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;WTAP;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
ENSG00000075415.11,SLC25A3
COADEAGMEXENSG00000160714.5chr1154551459:154551492:154551770:154551819:154551819:154551979:154552092:154552183-0.22793.7661e-023.7935e-14-0.4427imageNACIN1;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM47;RC3H1;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAEosinophilsGSVA_HALLMARK_P53_PATHWAY
chr12:98596733-98597620:+
ESCAEERIRENSG00000014914.15chr1149928650:149930965:149931259:149931426-0.40088.5536e-033.0645e-06-0.4020imageNADARNAT_cells_CD4_memory_restingGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr12:98596733-98597620:+
ESCAEERIRENSG00000078043.11chr1846808389:46812612:46815311:46815349-0.41355.3445e-031.2026e-06-0.4199imageNADARPIAS2T_cells_CD4_memory_restingGSVA_HALLMARK_GLYCOLYSIS
chr12:98596733-98597620:+
ESCAEERMEXENSG00000184752.8chr1294971477:94971620:94972394:94972489:94974170:94974285:94994169:949942570.31382.9024e-023.7745e-060.4655imageNNNAPlasma_cellsGSVA_HALLMARK_MYOGENESIS
chr12:98596733-98597620:+
ESCAEERIRENSG00000145734.14chr571562273:71562520:71562774:71562895-0.36629.3534e-031.0793e-05-0.4225imageNADARNAT_cells_CD8GSVA_HALLMARK_APICAL_JUNCTION
chr12:98596733-98597620:+
ESCAEERIRENSG00000122566.16chr726189926:26190460:26190992:26191011-0.42085.7430e-031.2129e-06-0.4167imageNADARNAT_cells_CD4_memory_restingGSVA_HALLMARK_SPERMATOGENESIS
chr12:98596733-98597620:+
ESCAEERA5ENSG00000185917.9chr2136058815:36058924:36060346:36060363:36060281:36060363-0.33671.2212e-029.8025e-06-0.4323imageNADARNAGSVA_HALLMARK_DNA_REPAIR
chr12:98596733-98597620:+
ESCAEERIRENSG00000006194.6chr163282942:3285239:3285680:3285754-0.30423.3316e-027.1549e-05-0.4040imageNADARNAT_cells_CD4_memory_restingGSVA_HALLMARK_GLYCOLYSIS
chr12:98596733-98597620:+
ESCAEERIRENSG00000101057.11chr2043709962:43710810:43711487:43711601-0.29764.9449e-026.0197e-05-0.4016imageNADARNAMacrophages_M2GSVA_HALLMARK_P53_PATHWAY

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5. Enriched editing regions and immune infiltration for SLC25A3


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr12:98603931-98606118:+ACCEERMacrophages_M14.1284e-02-0.2302image
ENSG00000075415.11,SLC25A3ACCEAGMacrophages_M12.3550e-02-0.2546image
chr12:98596733-98597620:+BLCAEERT_cells_CD4_memory_activated3.6679e-020.2052image
chr12:98603931-98606118:+BLCAEERT_cells_CD4_memory_activated2.8790e-020.1236image
ENSG00000075415.11,SLC25A3BLCAEAGT_cells_CD4_memory_activated1.2144e-020.1383image
chr12:98603931-98606118:+BRCAEERT_cells_CD4_memory_activated2.6278e-040.1113image
ENSG00000075415.11,SLC25A3BRCAEAGT_cells_CD4_memory_activated1.2564e-040.1169image
chr12:98596733-98597620:+CESCEERMonocytes1.1393e-020.2642image
ENSG00000075415.11,SLC25A3CESCEAGMacrophages_M23.8193e-02-0.1248image
chr12:98603931-98606118:+CHOLEERNeutrophils1.8633e-020.3957image
ENSG00000075415.11,SLC25A3CHOLEAGNeutrophils2.4169e-020.3804image
chr12:98596733-98597620:+COADEERDendritic_cells_resting8.8785e-03-0.2839image
ENSG00000075415.11,SLC25A3COADEAGDendritic_cells_activated2.8691e-070.3090image
chr12:98596733-98597620:+ESCAEERMacrophages_M12.5668e-030.2664image
chr12:98602195-98602441:+ESCAEERT_cells_CD4_memory_resting1.5179e-020.4072image
chr12:98603931-98606118:+ESCAEERMacrophages_M09.9023e-030.2040image
ENSG00000075415.11,SLC25A3ESCAEAGB_cells_naive2.0235e-04-0.2897image
chr12:98596733-98597620:+GBMEERDendritic_cells_activated2.4713e-030.5888image
chr12:98603931-98606118:+GBMEERMacrophages_M01.2920e-03-0.2477image
ENSG00000075415.11,SLC25A3GBMEAGMacrophages_M01.3447e-03-0.2469image
chr12:98602195-98602441:+HNSCEERT_cells_CD4_naive9.9620e-030.4359image
chr12:98603931-98606118:+HNSCEERT_cells_regulatory_(Tregs)8.4097e-04-0.1755image
ENSG00000075415.11,SLC25A3HNSCEAGT_cells_regulatory_(Tregs)1.9219e-04-0.1932image
chr12:98603931-98606118:+KICHEERNeutrophils1.2710e-020.3075image
ENSG00000075415.11,SLC25A3KICHEAGNeutrophils1.8199e-020.2922image
chr12:98596733-98597620:+KIRCEERPlasma_cells5.0783e-040.3382image
chr12:98603931-98606118:+KIRCEERPlasma_cells1.3711e-030.1628image
ENSG00000075415.11,SLC25A3KIRCEAGT_cells_CD4_memory_activated1.9346e-040.1889image
chr12:98596733-98597620:+KIRPEERMacrophages_M18.8469e-040.3646image
chr12:98603931-98606118:+KIRPEERT_cells_CD4_naive2.6250e-020.1316image
ENSG00000075415.11,SLC25A3KIRPEAGT_cells_CD4_naive5.6970e-040.2025image
chr12:98603931-98606118:+LGGEERT_cells_CD4_memory_activated1.7575e-040.1624image
ENSG00000075415.11,SLC25A3LGGEAGT_cells_CD4_memory_activated5.1098e-040.1506image
chr12:98603931-98606118:+LIHCEERT_cells_regulatory_(Tregs)1.6820e-03-0.1645image
ENSG00000075415.11,SLC25A3LIHCEAGT_cells_regulatory_(Tregs)8.6108e-04-0.1744image
chr12:98603931-98606118:+LUADEERMast_cells_resting4.6744e-03-0.1388image
ENSG00000075415.11,SLC25A3LUADEAGMast_cells_resting1.8708e-03-0.1508image
chr12:98603931-98606118:+LUSCEERT_cells_CD4_memory_activated2.7890e-020.1116image
ENSG00000075415.11,SLC25A3LUSCEAGT_cells_CD4_memory_resting1.7092e-02-0.1159image
chr12:98603931-98606118:+MESOEERT_cells_follicular_helper5.6153e-030.3032image
ENSG00000075415.11,SLC25A3MESOEAGT_cells_follicular_helper6.0118e-030.3009image
chr12:98603931-98606118:+OVEERMacrophages_M17.9667e-030.1569image
ENSG00000075415.11,SLC25A3OVEAGMacrophages_M11.3218e-020.1466image
chr12:98603931-98606118:+PAADEERT_cells_gamma_delta2.8094e-02-0.1675image
ENSG00000075415.11,SLC25A3PAADEAGMacrophages_M22.8923e-02-0.1657image
chr12:98603931-98606118:+PCPGEERT_cells_CD81.6592e-020.1769image
ENSG00000075415.11,SLC25A3PCPGEAGT_cells_CD81.9818e-020.1721image
chr12:98596733-98597620:+PRADEERPlasma_cells3.6101e-02-0.2712image
chr12:98603931-98606118:+PRADEERDendritic_cells_activated3.1024e-020.0969image
ENSG00000075415.11,SLC25A3PRADEAGDendritic_cells_activated2.0225e-020.1042image
chr12:98603931-98606118:+SARCEERT_cells_CD4_memory_activated7.3262e-040.2102image
ENSG00000075415.11,SLC25A3SARCEAGT_cells_CD4_memory_activated7.9110e-040.2089image
chr12:98603931-98606118:+SKCMEERT_cells_CD86.6681e-060.2180image
ENSG00000075415.11,SLC25A3SKCMEAGT_cells_CD87.5520e-050.1915image
chr12:98596733-98597620:+STADEERMacrophages_M21.4243e-020.1877image
chr12:98603931-98606118:+STADEERT_cells_CD4_memory_activated1.2589e-040.2044image
ENSG00000075415.11,SLC25A3STADEAGT_cells_CD4_memory_activated1.0642e-030.1740image
chr12:98603931-98606118:+TGCTEERT_cells_CD4_memory_activated7.2305e-040.3537image
ENSG00000075415.11,SLC25A3TGCTEAGMacrophages_M29.8292e-04-0.2913image
chr12:98603931-98606118:+THCAEERDendritic_cells_activated3.3090e-050.1838image
ENSG00000075415.11,SLC25A3THCAEAGDendritic_cells_activated3.0849e-060.2061image
chr12:98603931-98606118:+THYMEERDendritic_cells_activated6.1630e-050.3602image
ENSG00000075415.11,SLC25A3THYMEAGDendritic_cells_activated4.5926e-050.3660image
chr12:98603931-98606118:+UCECEERT_cells_follicular_helper1.1607e-02-0.1973image
ENSG00000075415.11,SLC25A3UCECEAGT_cells_follicular_helper1.2994e-02-0.1936image
chr12:98603931-98606118:+UCSEERNeutrophils2.0592e-050.5447image
ENSG00000075415.11,SLC25A3UCSEAGNeutrophils1.2339e-050.5567image
chr12:98603931-98606118:+UVMEERMacrophages_M21.1236e-020.2952image
ENSG00000075415.11,SLC25A3UVMEAGMacrophages_M21.3580e-020.2877image


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6. Enriched editing regions and immune gene sets for SLC25A3


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr12:98603931-98606118:+BLCAEER4.6168e-030.15978.5121e-030.14853.9704e-030.16244.9672e-040.1957image
ENSG00000075415.11,SLC25A3BLCAEAG5.2166e-030.15391.7299e-030.17249.9892e-040.18091.6429e-030.1732image
ENSG00000075415.11,SLC25A3LUADEAG3.6276e-020.10186.7455e-030.13154.5380e-020.09741.9216e-030.1504image
chr12:98603931-98606118:+SARCEER3.4730e-040.22232.9001e-050.25861.0368e-020.16034.1484e-040.2195image
ENSG00000075415.11,SLC25A3SARCEAG5.7644e-040.21414.0568e-050.25401.4827e-020.15249.8511e-040.2051image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000075415.11,SLC25A3BLCAGSVA_HALLMARK_MTORC1_SIGNALINGEAG4.4808e-040.1927image
chr12:98596733-98597620:+BLCAGSVA_HALLMARK_E2F_TARGETSEER9.2303e-030.2542image
chr12:98603931-98606118:+BLCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER1.2792e-050.2439image
ENSG00000075415.11,SLC25A3BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG7.9939e-120.2068image
chr12:98596733-98597620:+BRCAGSVA_HALLMARK_MITOTIC_SPINDLEEER7.0276e-040.2444image
chr12:98603931-98606118:+BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER8.1440e-120.2069image
ENSG00000075415.11,SLC25A3CESCGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.8648e-030.1865image
chr12:98596733-98597620:+CESCGSVA_HALLMARK_PEROXISOMEEER2.9128e-020.2288image
chr12:98603931-98606118:+CESCGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.7893e-030.1875image
chr12:98603931-98606118:+CHOLGSVA_HALLMARK_MYOGENESISEER1.3218e-02-0.4148image
ENSG00000075415.11,SLC25A3CHOLGSVA_HALLMARK_MYOGENESISEAG1.8171e-02-0.3971image
ENSG00000075415.11,SLC25A3COADGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG1.9823e-020.1430image
chr12:98603931-98606118:+COADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.4804e-030.1880image
chr12:98596733-98597620:+COADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.5051e-020.2645image
chr12:98596733-98597620:+ESCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER3.8003e-030.2561image
ENSG00000075415.11,SLC25A3ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG2.7007e-030.2357image
chr12:98603931-98606118:+GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER9.3067e-070.3700image
chr12:98596733-98597620:+GBMGSVA_HALLMARK_PANCREAS_BETA_CELLSEER5.9107e-030.5448image
ENSG00000075415.11,SLC25A3GBMGSVA_HALLMARK_BILE_ACID_METABOLISMEAG5.0559e-070.3782image
chr12:98596733-98597620:+HNSCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER2.5738e-020.2704image
ENSG00000075415.11,SLC25A3HNSCGSVA_HALLMARK_MTORC1_SIGNALINGEAG1.7984e-030.1622image
chr12:98603931-98606118:+HNSCGSVA_HALLMARK_TGF_BETA_SIGNALINGEER1.2378e-030.1698image
chr12:98603931-98606118:+KICHGSVA_HALLMARK_KRAS_SIGNALING_DNEER4.1962e-03-0.3506image
ENSG00000075415.11,SLC25A3KICHGSVA_HALLMARK_KRAS_SIGNALING_DNEAG3.2382e-03-0.3598image
chr12:98603931-98606118:+KIRCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER3.3283e-03-0.1494image
ENSG00000075415.11,SLC25A3KIRCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.3228e-02-0.1262image
chr12:98596733-98597620:+KIRCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.5765e-020.2208image
ENSG00000075415.11,SLC25A3KIRPGSVA_HALLMARK_GLYCOLYSISEAG1.5450e-040.2219image
chr12:98596733-98597620:+KIRPGSVA_HALLMARK_HYPOXIAEER1.7815e-030.3440image
chr12:98603931-98606118:+KIRPGSVA_HALLMARK_GLYCOLYSISEER1.1990e-040.2259image
ENSG00000075415.11,SLC25A3LAMLGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.2314e-020.2165image
chr12:98603931-98606118:+LGGGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER2.0105e-130.3122image
ENSG00000075415.11,SLC25A3LGGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.5825e-120.3008image
chr12:98603931-98606118:+LIHCGSVA_HALLMARK_HEME_METABOLISMEER4.1434e-070.2623image
ENSG00000075415.11,SLC25A3LIHCGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.5934e-070.2712image
ENSG00000075415.11,SLC25A3LUADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG2.8318e-040.1756image
chr12:98603931-98606118:+LUADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER1.4134e-030.1564image
chr12:98596733-98597620:+LUADGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER1.9938e-040.3094image
chr12:98596733-98597620:+LUSCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.3624e-030.2222image
ENSG00000075415.11,SLC25A3LUSCGSVA_HALLMARK_MTORC1_SIGNALINGEAG3.2949e-030.1426image
chr12:98603931-98606118:+MESOGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER9.6957e-030.2841image
ENSG00000075415.11,SLC25A3MESOGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG4.9128e-030.3078image
chr12:98603931-98606118:+OVGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER3.7947e-080.3187image
ENSG00000075415.11,SLC25A3OVGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG4.2913e-080.3175image
chr12:98603931-98606118:+PAADGSVA_HALLMARK_GLYCOLYSISEER3.3012e-040.2706image
ENSG00000075415.11,SLC25A3PAADGSVA_HALLMARK_GLYCOLYSISEAG8.5171e-040.2506image
chr12:98603931-98606118:+PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.2769e-040.2794image
ENSG00000075415.11,SLC25A3PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.1269e-050.2918image
chr12:98596733-98597620:+PRADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER1.6802e-020.3076image
chr12:98603931-98606118:+PRADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.8784e-03-0.1393image
ENSG00000075415.11,SLC25A3PRADGSVA_HALLMARK_E2F_TARGETSEAG6.4750e-030.1221image
ENSG00000075415.11,SLC25A3READGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.2999e-040.3885image
chr12:98603931-98606118:+READGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.3008e-040.3884image
ENSG00000075415.11,SLC25A3SARCGSVA_HALLMARK_E2F_TARGETSEAG6.2149e-040.2129image
chr12:98603931-98606118:+SARCGSVA_HALLMARK_HYPOXIAEER4.1484e-040.2195image
chr12:98603931-98606118:+SKCMGSVA_HALLMARK_COMPLEMENTEER1.8464e-110.3204image
ENSG00000075415.11,SLC25A3SKCMGSVA_HALLMARK_COMPLEMENTEAG2.1045e-090.2863image
chr12:98596733-98597620:+STADGSVA_HALLMARK_PANCREAS_BETA_CELLSEER2.8814e-020.1677image
ENSG00000075415.11,SLC25A3STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.2445e-080.2980image
chr12:98603931-98606118:+STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.0968e-090.3145image
chr12:98603931-98606118:+TGCTGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.3696e-040.3823image
ENSG00000075415.11,SLC25A3TGCTGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.3482e-030.2836image
ENSG00000075415.11,SLC25A3THCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG3.3903e-160.3525image
chr12:98603931-98606118:+THCAGSVA_HALLMARK_GLYCOLYSISEER1.9409e-160.3553image
ENSG00000075415.11,SLC25A3THYMGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG4.9644e-060.4064image
chr12:98603931-98606118:+THYMGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER3.2066e-060.4138image
chr12:98603931-98606118:+UCECGSVA_HALLMARK_PEROXISOMEEER1.1108e-03-0.2532image
ENSG00000075415.11,SLC25A3UCECGSVA_HALLMARK_PEROXISOMEEAG3.1785e-03-0.2290image
ENSG00000075415.11,SLC25A3UCSGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG2.6980e-02-0.3010image
chr12:98603931-98606118:+UCSGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER2.8767e-02-0.2977image
ENSG00000075415.11,SLC25A3UVMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG2.0319e-060.5233image
chr12:98603931-98606118:+UVMGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.5398e-060.5285image


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7. Enriched editing regions and drugs for SLC25A3


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr12:98603931-98606118:+ACCABT.888EER2.1427e-030.3404image
ENSG00000075415.11,SLC25A3ACCABT.888EAG1.2882e-030.3559image
ENSG00000075415.11,SLC25A3BLCAGefitinibEAG5.6308e-04-0.1897image
chr12:98603931-98606118:+BLCACMKEER2.4827e-04-0.2057image
chr12:98596733-98597620:+BLCABI.D1870EER3.1358e-02-0.2112image
ENSG00000075415.11,SLC25A3BRCAJNK.Inhibitor.VIIIEAG3.0000e-09-0.1800image
chr12:98603931-98606118:+BRCACGP.082996EER4.3180e-09-0.1782image
chr12:98596733-98597620:+BRCABIBW2992EER2.9357e-02-0.1585image
ENSG00000075415.11,SLC25A3CESCGSK.650394EAG3.7367e-030.1740image
chr12:98603931-98606118:+CESCGSK.650394EER4.6190e-030.1703image
chr12:98603931-98606118:+CHOLEHT.1864EER2.9468e-030.4879image
ENSG00000075415.11,SLC25A3CHOLEHT.1864EAG1.6164e-030.5132image
chr12:98603931-98606118:+COADGW843682XEER2.2405e-020.1424image
chr12:98596733-98597620:+COADAKT.inhibitor.VIIIEER2.0254e-030.3321image
ENSG00000075415.11,SLC25A3COADBMS.509744EAG1.1706e-030.1984image
ENSG00000075415.11,SLC25A3ESCACGP.60474EAG1.6734e-04-0.2933image
chr12:98602195-98602441:+ESCAAZD8055EER6.2561e-040.5497image
chr12:98603931-98606118:+ESCACGP.60474EER1.3882e-02-0.1948image
chr12:98596733-98597620:+ESCADocetaxelEER2.5177e-04-0.3206image
chr12:98596733-98597620:+GBMKU.55933EER1.5535e-02-0.4881image
ENSG00000075415.11,SLC25A3GBMBIBW2992EAG2.7827e-10-0.4649image
chr12:98603931-98606118:+GBMBIBW2992EER4.1341e-10-0.4609image
ENSG00000075415.11,SLC25A3HNSCBX.795EAG5.4743e-04-0.1793image
chr12:98596733-98597620:+HNSCJNK.Inhibitor.VIIIEER7.7355e-030.3204image
chr12:98602195-98602441:+HNSCMethotrexateEER9.1182e-030.4405image
chr12:98603931-98606118:+HNSCBX.795EER3.7068e-04-0.1869image
ENSG00000075415.11,SLC25A3KICHCytarabineEAG9.5271e-07-0.5648image
chr12:98603931-98606118:+KICHCytarabineEER1.6996e-06-0.5539image
ENSG00000075415.11,SLC25A3KIRCAZD6244EAG5.0141e-13-0.3572image
chr12:98596733-98597620:+KIRCKU.55933EER1.0286e-03-0.3204image
chr12:98603931-98606118:+KIRCAZD6244EER1.6415e-14-0.3783image
chr12:98596733-98597620:+KIRPCGP.082996EER6.7573e-03-0.3005image
chr12:98603931-98606118:+KIRPEHT.1864EER2.3683e-050.2476image
ENSG00000075415.11,SLC25A3KIRPEHT.1864EAG1.1579e-050.2561image
ENSG00000075415.11,SLC25A3LAMLCHIR.99021EAG2.6241e-02-0.1927image
chr12:98603931-98606118:+LGGBAY.61.3606EER1.5065e-210.3982image
ENSG00000075415.11,SLC25A3LGGBAY.61.3606EAG4.7663e-200.3842image
chr12:98603931-98606118:+LIHCBIBW2992EER7.4422e-03-0.1496image
ENSG00000075415.11,SLC25A3LIHCBIBW2992EAG6.5010e-03-0.1521image
ENSG00000075415.11,SLC25A3LUADCMKEAG5.3547e-03-0.1352image
chr12:98603931-98606118:+LUADCMKEER1.5006e-02-0.1195image
chr12:98596733-98597620:+LUADKIN001.135EER5.8165e-03-0.2320image
chr12:98596733-98597620:+LUSCJNK.Inhibitor.VIIIEER1.1841e-030.2366image
chr12:98603931-98606118:+LUSCCGP.082996EER1.9232e-03-0.1570image
ENSG00000075415.11,SLC25A3LUSCCGP.082996EAG2.7141e-04-0.1762image
ENSG00000075415.11,SLC25A3MESOCGP.082996EAG9.6537e-03-0.2842image
chr12:98603931-98606118:+MESOCGP.082996EER1.4150e-02-0.2700image
chr12:98603931-98606118:+OVBAY.61.3606EER8.7468e-060.2600image
ENSG00000075415.11,SLC25A3OVBAY.61.3606EAG1.3551e-050.2546image
ENSG00000075415.11,SLC25A3PAADBIBW2992EAG1.4306e-04-0.2844image
chr12:98603931-98606118:+PAADBIBW2992EER7.4734e-04-0.2547image
chr12:98603931-98606118:+PCPGGSK269962AEER4.2087e-050.2979image
ENSG00000075415.11,SLC25A3PCPGGSK269962AEAG1.7090e-050.3120image
ENSG00000075415.11,SLC25A3PRADBMS.754807EAG9.7600e-070.2178image
chr12:98603931-98606118:+PRADBMS.754807EER7.1089e-060.2001image
ENSG00000075415.11,SLC25A3READBX.795EAG7.4549e-03-0.2773image
chr12:98603931-98606118:+READBX.795EER5.7847e-03-0.2856image
chr12:98603931-98606118:+SARCCGP.082996EER4.4530e-06-0.2829image
ENSG00000075415.11,SLC25A3SARCCGP.082996EAG8.0267e-06-0.2755image
chr12:98603931-98606118:+SKCMAZD7762EER4.9096e-08-0.2626image
ENSG00000075415.11,SLC25A3SKCMAZD7762EAG3.7789e-08-0.2638image
chr12:98603931-98606118:+STADAG.014699EER2.6655e-030.1610image
ENSG00000075415.11,SLC25A3STADCCT007093EAG2.6502e-030.1600image
chr12:98596733-98597620:+STADBMS.536924EER2.2321e-03-0.2330image
ENSG00000075415.11,SLC25A3TGCTCamptothecinEAG1.3225e-04-0.3353image
chr12:98603931-98606118:+TGCTGemcitabineEER1.4708e-04-0.3938image
ENSG00000075415.11,SLC25A3THCACI.1040EAG4.3375e-09-0.2577image
chr12:98603931-98606118:+THCACI.1040EER5.1525e-11-0.2870image
chr12:98603931-98606118:+THYMEmbelinEER2.0913e-050.3809image
ENSG00000075415.11,SLC25A3THYMGSK269962AEAG7.8203e-050.3554image
chr12:98603931-98606118:+UCECA.770041EER1.6000e-09-0.4505image
ENSG00000075415.11,SLC25A3UCECA.770041EAG3.1387e-09-0.4419image
chr12:98603931-98606118:+UCSEmbelinEER3.4682e-020.2880image
ENSG00000075415.11,SLC25A3UCSEmbelinEAG2.1976e-020.3112image
ENSG00000075415.11,SLC25A3UVMBexaroteneEAG1.9249e-10-0.6612image
chr12:98603931-98606118:+UVMBexaroteneEER1.1121e-10-0.6676image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType