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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: PEX13 (ImmuneEditome ID:5194)

1. Gene summary of enriched editing regions for PEX13

check button Gene summary
Gene informationGene symbol

PEX13

Gene ID

5194

GeneSynonymsNALD|PBD11A|PBD11B|ZWS
GeneCytomap

2p15

GeneTypeprotein-coding
GeneDescriptionperoxisome biogenesis factor 13|peroxin-13|peroxisomal membrane protein PEX13
GeneModificationdate20230329
UniprotIDQ92968;D3YTD3;G5E9N6;B5MBY9
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr2:61022586-61027348:+ENST00000472678.1ENSG00000162928.8PEX13ncRNA_intronicAluSz6,AluSg7,(ATT)n,AluJr,(T)n,L1MEg,AluJb,(TTTG)n,AluSg4,(AC)n,AluY,L1MEichr2:61022586-61027348:+.alignment
chr2:61049451-61050944:+ENST00000295030.5ENSG00000162928.8PEX13UTR3AluSx,AluSp,AluY,(TTAT)nchr2:61049451-61050944:+.alignment


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2. Tumor-specific enriched editing regions for PEX13


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr2:61049451-61050944:+BRCAEER2.0532e-06image
ENSG00000162928.8,PEX13BRCAEAG1.0434e-05image
chr2:61049451-61050944:+COADEER8.4382e-07image
ENSG00000162928.8,PEX13COADEAG5.3085e-07image
chr2:61049451-61050944:+HNSCEER1.1865e-04image
ENSG00000162928.8,PEX13HNSCEAG1.0507e-04image
chr2:61049451-61050944:+KIRCEER1.0621e-03image
ENSG00000162928.8,PEX13KIRCEAG7.7845e-04image
chr2:61049451-61050944:+LUSCEER2.6489e-03image
ENSG00000162928.8,PEX13LUSCEAG4.9588e-04image
chr2:61049451-61050944:+THCAEER5.5773e-03image
ENSG00000162928.8,PEX13THCAEAG1.8962e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr2:61049451-61050944:+KIRCPathEER2.6605e-033.2802e-040.1606image
ENSG00000162928.8,PEX13KIRCPathEAG2.0608e-034.0377e-040.1582image
chr2:61049451-61050944:+LIHCPathEER2.0987e-023.0882e-02-0.1211image
ENSG00000162928.8,PEX13LIHCPathEAG2.2072e-023.2325e-02-0.1199image
ENSG00000162928.8,PEX13LUSCPathEAG2.3927e-021.3729e-020.1118image
chr2:61049451-61050944:+LUSCPathEER3.6415e-021.3933e-020.1117image
ENSG00000162928.8,PEX13THCAPathEAG8.6267e-031.1369e-030.1466image
chr2:61049451-61050944:+THCAPathEER2.4916e-041.3260e-050.1958image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr2:61049451-61050944:+COADEER9.1547e-033.9307e-024.1705e+01image
ENSG00000162928.8,PEX13COADEAG9.1547e-034.5571e-023.6807e+01image
chr2:61049451-61050944:+LUADEER1.2038e-029.7986e-041.0026e+02image
ENSG00000162928.8,PEX13LUADEAG1.7294e-022.1367e-035.8322e+01image

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3. Enriched editing regions and immune related genes for PEX13


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr2:61049451-61050944:+BLCAEERENSG00000064787,BCAS1-0.49667.6361e-219.9179e-18-0.4222imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_E2F_TARGETS
chr2:61049451-61050944:+BLCAEERENSG00000142089,IFITM30.45602.3598e-172.2886e-170.4179imageNNIFITM3T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr2:61049451-61050944:+BLCAEERENSG00000158122,AAED10.45192.6181e-172.1351e-250.5014imageNNNAMacrophages_M1GSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr2:61049451-61050944:+BLCAEERENSG00000129514,FOXA1-0.45232.6488e-171.4029e-17-0.4204imageNNNADendritic_cells_activatedGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr2:61049451-61050944:+BLCAEERENSG00000197905,TEAD40.44591.4410e-162.4701e-180.4293imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALING
chr2:61049451-61050944:+BLCAEERENSG00000114450,GNB40.43309.1825e-161.0239e-160.4100imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr2:61049451-61050944:+BLCAEERENSG00000164111,ANXA50.42761.2438e-151.9870e-210.4630imageNNANXA5T_cells_CD4_memory_activatedGSVA_HALLMARK_COMPLEMENT
chr2:61049451-61050944:+BLCAEERENSG00000096060,FKBP50.42621.3685e-152.1172e-160.4061imageNNFKBP5T_cells_CD4_memory_activatedGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALING
chr2:61049451-61050944:+BLCAEERENSG00000130830,MPP10.42692.5216e-153.2672e-230.4809imageNNMPP1Macrophages_M2GSVA_HALLMARK_ALLOGRAFT_REJECTION
chr2:61049451-61050944:+BLCAEERENSG00000142227,EMP30.41843.1597e-153.6649e-280.5256imageNNNAMacrophages_M2GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION

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4. Enriched editing regions and immune related splicing for PEX13


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr2:61049451-61050944:+
BLCAEERESENSG00000074964.12chr117632320:17632466:17634547:17634562:17634834:17635016-0.36655.6046e-111.1690e-20-0.4673imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
ENSG00000162928.8,PEX13
BLCAEAGIRENSG00000205744.5chr196467206:6468645:6468845:6468953-0.33704.2505e-091.7672e-18-0.4406imageNADAR;BCCIP;CELF2;CSTF2T;DGCR8;DKC1;EIF4A3;EIF4G2;ELAVL1;FBL;FUS;FXR1;GTF2F1;HNRNPC;HNRNPL;HNRNPM;HNRNPU;IGF2BP2;LIN28;LIN28B;NOP56;NOP58;PRPF8;SRSF7;TAF15;TARDBP;TROVE2;U2AF1;U2AF2;UPF1NADendritic_cells_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr2:61049451-61050944:+
BLCAEERA5ENSG00000074964.12chr117634834:17635016:17632320:17632466:17632320:176345620.36576.7021e-113.2220e-200.4619imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
ENSG00000162928.8,PEX13
BLCAEAGESENSG00000090989.13chr455883822:55883928:55888887:55888932:55890222:55890386-0.33676.2707e-098.0007e-16-0.4074imageNACIN1;ADAR;ALYREF;AUH;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LIN28;LIN28B;MOV10;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM47;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZNF184EXOC1Macrophages_M1GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
ENSG00000162928.8,PEX13
BLCAEAGIRENSG00000189171.9chr1153626319:153626533:153626950:153627048-0.29093.4467e-084.0395e-13-0.4008imageNACIN1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHSRP;LIN28;LIN28A;LIN28B;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;ZNF184S100A13Dendritic_cells_activatedGSVA_HALLMARK_COMPLEMENT
chr2:61049451-61050944:+
BLCAEERIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.48211.2047e-174.5616e-19-0.4381imageNNPRKCSHMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
ENSG00000162928.8,PEX13
BLCAEAGIRENSG00000111615.8chr1275496903:75499951:75501722:755018160.33054.1658e-084.6597e-160.4018imageNACIN1;ADAR;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM47;RBM5;RC3H1;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZFP36;ZNF184NAMacrophages_M2GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr2:61049451-61050944:+
BLCAEERESENSG00000065613.9chr10104008197:104008356:104010815:104010908:104018159:104018289-0.36652.8221e-101.3533e-18-0.4354imageNNSLKDendritic_cells_activatedGSVA_HALLMARK_PANCREAS_BETA_CELLS
chr2:61049451-61050944:+
BLCAEERA5ENSG00000167110.12chr9128268419:128268524:128273849:128273853:128272784:128273853-0.35285.6609e-106.6368e-16-0.4100imageNNNADendritic_cells_activatedGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
ENSG00000162928.8,PEX13
BLCAEAGIRENSG00000205744.5chr196467206:6468441:6468577:6468645-0.30912.2010e-071.1842e-15-0.4036imageNADAR;BCCIP;CELF2;CSTF2T;DGCR8;DKC1;EIF4A3;EIF4G2;ELAVL1;FBL;FUS;FXR1;GTF2F1;HNRNPC;HNRNPL;HNRNPM;HNRNPU;IGF2BP2;LIN28;LIN28B;NOP56;NOP58;PRPF8;SRSF7;TAF15;TARDBP;TROVE2;U2AF1;U2AF2;UPF1NADendritic_cells_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION

More results



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5. Enriched editing regions and immune infiltration for PEX13


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr2:61022586-61027348:+BLCAEERNK_cells_resting1.3229e-020.3156image
chr2:61049451-61050944:+BLCAEERT_cells_CD4_memory_activated1.7961e-080.2849image
ENSG00000162928.8,PEX13BLCAEAGT_cells_CD4_memory_activated2.1094e-080.2836image
chr2:61022586-61027348:+BRCAEERDendritic_cells_activated4.6604e-030.4143image
chr2:61049451-61050944:+BRCAEERT_cells_regulatory_(Tregs)8.7027e-060.1357image
ENSG00000162928.8,PEX13BRCAEAGT_cells_regulatory_(Tregs)1.3338e-050.1329image
chr2:61049451-61050944:+CESCEERT_cells_CD4_memory_resting3.5744e-04-0.2111image
ENSG00000162928.8,PEX13CESCEAGT_cells_CD4_memory_resting1.6402e-04-0.2222image
chr2:61049451-61050944:+CHOLEERT_cells_CD4_naive4.9579e-050.6378image
ENSG00000162928.8,PEX13CHOLEAGT_cells_CD4_naive4.9579e-050.6378image
chr2:61049451-61050944:+COADEERMacrophages_M13.1448e-040.2213image
ENSG00000162928.8,PEX13COADEAGMacrophages_M17.2521e-040.2075image
chr2:61022586-61027348:+ESCAEERB_cells_naive2.1880e-02-0.2291image
chr2:61049451-61050944:+ESCAEERMacrophages_M22.1960e-090.4508image
ENSG00000162928.8,PEX13ESCAEAGMacrophages_M21.1037e-040.3009image
chr2:61049451-61050944:+GBMEERT_cells_regulatory_(Tregs)1.6869e-020.1949image
ENSG00000162928.8,PEX13GBMEAGT_cells_regulatory_(Tregs)1.6869e-020.1949image
chr2:61049451-61050944:+HNSCEERMacrophages_M13.6484e-050.1900image
ENSG00000162928.8,PEX13HNSCEAGMacrophages_M15.3890e-050.1859image
chr2:61049451-61050944:+KICHEERT_cells_follicular_helper3.3540e-020.3552image
ENSG00000162928.8,PEX13KICHEAGT_cells_follicular_helper3.3540e-020.3552image
chr2:61049451-61050944:+KIRCEERT_cells_regulatory_(Tregs)3.4509e-050.2173image
ENSG00000162928.8,PEX13KIRCEAGT_cells_regulatory_(Tregs)1.2008e-050.2294image
chr2:61049451-61050944:+KIRPEERT_cells_CD4_naive1.3091e-020.1587image
ENSG00000162928.8,PEX13KIRPEAGNK_cells_activated6.6201e-030.1730image
chr2:61049451-61050944:+LGGEERMacrophages_M03.9969e-02-0.1024image
ENSG00000162928.8,PEX13LGGEAGMacrophages_M03.9969e-02-0.1024image
chr2:61049451-61050944:+LIHCEERMacrophages_M13.1236e-030.1594image
ENSG00000162928.8,PEX13LIHCEAGMacrophages_M13.2082e-030.1587image
chr2:61022586-61027348:+LUADEERPlasma_cells6.9064e-030.4546image
chr2:61049451-61050944:+LUADEERT_cells_CD4_memory_activated1.1442e-060.2166image
ENSG00000162928.8,PEX13LUADEAGT_cells_CD4_memory_activated1.5840e-070.2327image
chr2:61049451-61050944:+LUSCEERT_cells_CD4_memory_activated1.7493e-050.1937image
ENSG00000162928.8,PEX13LUSCEAGT_cells_CD4_memory_activated1.6064e-040.1704image
chr2:61049451-61050944:+MESOEERT_cells_gamma_delta2.1280e-020.2674image
ENSG00000162928.8,PEX13MESOEAGT_cells_gamma_delta2.1280e-020.2674image
chr2:61049451-61050944:+OVEERT_cells_CD83.9752e-060.2689image
ENSG00000162928.8,PEX13OVEAGT_cells_CD81.9138e-050.2498image
chr2:61049451-61050944:+PAADEERNK_cells_activated1.6418e-020.1871image
ENSG00000162928.8,PEX13PAADEAGNK_cells_activated1.6418e-020.1871image
chr2:61049451-61050944:+PCPGEERT_cells_CD4_memory_resting3.6969e-02-0.1861image
ENSG00000162928.8,PEX13PCPGEAGT_cells_CD4_memory_resting3.6969e-02-0.1861image
chr2:61049451-61050944:+PRADEERT_cells_regulatory_(Tregs)3.1148e-040.1644image
ENSG00000162928.8,PEX13PRADEAGT_cells_regulatory_(Tregs)3.0147e-040.1646image
chr2:61049451-61050944:+SARCEERMast_cells_resting2.1024e-03-0.2212image
ENSG00000162928.8,PEX13SARCEAGMast_cells_resting4.2065e-03-0.2057image
chr2:61049451-61050944:+SKCMEERMacrophages_M17.4696e-030.1524image
ENSG00000162928.8,PEX13SKCMEAGMacrophages_M12.6704e-020.1263image
chr2:61022586-61027348:+STADEERMacrophages_M21.4073e-020.1886image
chr2:61049451-61050944:+STADEERT_cells_gamma_delta4.7125e-040.1892image
ENSG00000162928.8,PEX13STADEAGT_cells_gamma_delta2.8746e-030.1607image
chr2:61049451-61050944:+TGCTEERMacrophages_M21.0944e-04-0.3431image
ENSG00000162928.8,PEX13TGCTEAGMacrophages_M22.3792e-04-0.3269image
chr2:61049451-61050944:+THCAEERT_cells_regulatory_(Tregs)1.7994e-070.2333image
ENSG00000162928.8,PEX13THCAEAGT_cells_regulatory_(Tregs)2.3119e-070.2308image
chr2:61049451-61050944:+THYMEERMast_cells_activated2.9563e-020.2498image
ENSG00000162928.8,PEX13THYMEAGMast_cells_activated3.3452e-020.2443image
chr2:61049451-61050944:+UCECEERMacrophages_M18.7023e-040.2691image
chr2:61049451-61050944:+UCSEERB_cells_naive2.6359e-02-0.3140image
ENSG00000162928.8,PEX13UCSEAGB_cells_naive2.0538e-02-0.3236image


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6. Enriched editing regions and immune gene sets for PEX13


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr2:61049451-61050944:+BLCAEER1.4955e-05image1.9166e-120.3521image
ENSG00000162928.8,PEX13BLCAEAG1.3224e-05image8.3650e-120.3423image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr2:61049451-61050944:+LUADEER3.2261e-100.27771.0113e-070.23651.8721e-080.24946.2159e-100.2734image
ENSG00000162928.8,PEX13LUADEAG1.9933e-100.28062.2441e-080.24789.4108e-090.25422.0325e-080.2485image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000162928.8,PEX13BLCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG1.0066e-150.3975image
chr2:61049451-61050944:+BLCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER6.9545e-170.4120image
chr2:61049451-61050944:+BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.7229e-280.3288image
ENSG00000162928.8,PEX13BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.6033e-260.3169image
ENSG00000162928.8,PEX13CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.1689e-080.3309image
chr2:61049451-61050944:+CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.1327e-100.3718image
chr2:61022586-61027348:+CESCGSVA_HALLMARK_ADIPOGENESISEER4.6532e-020.3490image
chr2:61049451-61050944:+CHOLGSVA_HALLMARK_ANGIOGENESISEER1.4759e-02-0.4146image
ENSG00000162928.8,PEX13CHOLGSVA_HALLMARK_ANGIOGENESISEAG1.4759e-02-0.4146image
chr2:61049451-61050944:+COADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER6.9092e-050.2438image
ENSG00000162928.8,PEX13COADGSVA_HALLMARK_PEROXISOMEEAG8.4289e-05-0.2405image
chr2:61022586-61027348:+ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER3.7983e-030.2869image
ENSG00000162928.8,PEX13ESCAGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.8506e-04-0.2914image
chr2:61049451-61050944:+ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER1.6198e-030.2473image
chr2:61049451-61050944:+GBMGSVA_HALLMARK_MYOGENESISEER3.7124e-020.1704image
ENSG00000162928.8,PEX13GBMGSVA_HALLMARK_MYOGENESISEAG3.7124e-020.1704image
ENSG00000162928.8,PEX13HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.6368e-090.2747image
chr2:61049451-61050944:+HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER6.8965e-100.2807image
ENSG00000162928.8,PEX13KICHGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG2.1064e-020.3832image
chr2:61049451-61050944:+KICHGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER2.1064e-020.3832image
ENSG00000162928.8,PEX13KIRCGSVA_HALLMARK_ANDROGEN_RESPONSEEAG3.3346e-07-0.2662image
chr2:61049451-61050944:+KIRCGSVA_HALLMARK_UV_RESPONSE_DNEER1.4889e-06-0.2515image
chr2:61049451-61050944:+KIRPGSVA_HALLMARK_UV_RESPONSE_DNEER5.1746e-04-0.2206image
ENSG00000162928.8,PEX13KIRPGSVA_HALLMARK_UV_RESPONSE_DNEAG2.5756e-04-0.2315image
ENSG00000162928.8,PEX13LGGGSVA_HALLMARK_G2M_CHECKPOINTEAG7.9605e-03-0.1320image
chr2:61049451-61050944:+LGGGSVA_HALLMARK_G2M_CHECKPOINTEER7.9605e-03-0.1320image
ENSG00000162928.8,PEX13LIHCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.0634e-100.3345image
chr2:61049451-61050944:+LIHCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.7614e-100.3362image
ENSG00000162928.8,PEX13LUADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG9.9818e-110.2851image
chr2:61049451-61050944:+LUADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER4.4732e-120.3044image
chr2:61022586-61027348:+LUSCGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER4.8728e-020.2028image
ENSG00000162928.8,PEX13LUSCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.1628e-06-0.2184image
chr2:61049451-61050944:+LUSCGSVA_HALLMARK_PEROXISOMEEER1.5721e-05-0.1947image
chr2:61049451-61050944:+MESOGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER4.4351e-020.2345image
ENSG00000162928.8,PEX13MESOGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG4.4351e-020.2345image
chr2:61022586-61027348:+OVGSVA_HALLMARK_P53_PATHWAYEER6.4669e-030.3021image
ENSG00000162928.8,PEX13OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.7477e-090.3424image
chr2:61049451-61050944:+OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER6.4477e-120.3916image
chr2:61049451-61050944:+PAADGSVA_HALLMARK_UV_RESPONSE_DNEER1.6721e-04-0.2898image
ENSG00000162928.8,PEX13PAADGSVA_HALLMARK_UV_RESPONSE_DNEAG1.6721e-04-0.2898image
ENSG00000162928.8,PEX13PCPGGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG1.9876e-02-0.2073image
chr2:61049451-61050944:+PCPGGSVA_HALLMARK_TGF_BETA_SIGNALINGEER1.9876e-02-0.2073image
chr2:61049451-61050944:+PRADGSVA_HALLMARK_ANDROGEN_RESPONSEEER4.5204e-15-0.3486image
ENSG00000162928.8,PEX13PRADGSVA_HALLMARK_ANDROGEN_RESPONSEEAG3.6755e-15-0.3493image
ENSG00000162928.8,PEX13SARCGSVA_HALLMARK_HYPOXIAEAG1.1048e-020.1830image
chr2:61049451-61050944:+SARCGSVA_HALLMARK_HYPOXIAEER2.7592e-050.2984image
chr2:61049451-61050944:+SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.3091e-030.1733image
ENSG00000162928.8,PEX13SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG8.6455e-030.1494image
chr2:61022586-61027348:+STADGSVA_HALLMARK_ANGIOGENESISEER3.9342e-070.3784image
chr2:61049451-61050944:+STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER9.7956e-060.2379image
ENSG00000162928.8,PEX13STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.3638e-030.1538image
ENSG00000162928.8,PEX13TGCTGSVA_HALLMARK_MYC_TARGETS_V2EAG4.0841e-040.3151image
chr2:61049451-61050944:+TGCTGSVA_HALLMARK_MYC_TARGETS_V2EER1.0704e-030.2927image
ENSG00000162928.8,PEX13THCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG3.7158e-10-0.2779image
chr2:61049451-61050944:+THCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER2.1984e-09-0.2663image
chr2:61049451-61050944:+THYMGSVA_HALLMARK_GLYCOLYSISEER8.3132e-040.3755image
ENSG00000162928.8,PEX13THYMGSVA_HALLMARK_GLYCOLYSISEAG7.6024e-040.3780image
ENSG00000162928.8,PEX13UCECGSVA_HALLMARK_ANDROGEN_RESPONSEEAG4.6363e-06-0.3585image
chr2:61049451-61050944:+UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.1517e-040.2902image
ENSG00000162928.8,PEX13UCSGSVA_HALLMARK_DNA_REPAIREAG2.8069e-020.3077image


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7. Enriched editing regions and drugs for PEX13


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000162928.8,PEX13BLCACisplatinEAG4.2702e-17-0.4146image
chr2:61022586-61027348:+BLCABleomycinEER4.8514e-02-0.2537image
chr2:61049451-61050944:+BLCACisplatinEER1.3609e-17-0.4206image
ENSG00000162928.8,PEX13BRCAAZD.2281EAG3.3210e-06-0.1420image
chr2:61049451-61050944:+BRCAGNF.2EER1.2913e-06-0.1476image
chr2:61022586-61027348:+BRCAAZD6244EER2.4949e-020.3340image
ENSG00000162928.8,PEX13CESCDasatinibEAG3.1745e-09-0.3428image
chr2:61049451-61050944:+CESCCI.1040EER1.0493e-06-0.2859image
chr2:61022586-61027348:+CESCAP.24534EER1.5842e-020.4167image
ENSG00000162928.8,PEX13CHOLGDC.0449EAG2.5618e-03-0.5007image
chr2:61049451-61050944:+CHOLGDC.0449EER2.5618e-03-0.5007image
chr2:61049451-61050944:+COADJNJ.26854165EER2.9259e-04-0.2224image
ENSG00000162928.8,PEX13COADAICAREAG2.7370e-05-0.2560image
chr2:61022586-61027348:+ESCAGDC0941EER6.3160e-04-0.3360image
chr2:61049451-61050944:+ESCAFH535EER2.3455e-040.2869image
ENSG00000162928.8,PEX13ESCABIRB.0796EAG1.3028e-03-0.2521image
chr2:61049451-61050944:+GBMMetforminEER2.4418e-02-0.1837image
ENSG00000162928.8,PEX13GBMMetforminEAG2.4418e-02-0.1837image
chr2:61049451-61050944:+HNSCBMS.509744EER6.1530e-09-0.2651image
ENSG00000162928.8,PEX13HNSCBMS.509744EAG3.0497e-09-0.2702image
ENSG00000162928.8,PEX13KIRCEmbelinEAG1.0016e-060.2555image
chr2:61049451-61050944:+KIRCEmbelinEER4.1465e-060.2409image
ENSG00000162928.8,PEX13KIRPLapatinibEAG8.5664e-080.3339image
chr2:61049451-61050944:+KIRPLapatinibEER1.3319e-070.3298image
chr2:61049451-61050944:+LGGGefitinibEER3.9116e-03-0.1434image
ENSG00000162928.8,PEX13LGGGefitinibEAG3.9116e-03-0.1434image
ENSG00000162928.8,PEX13LIHCGSK.650394EAG1.3408e-110.3546image
chr2:61049451-61050944:+LIHCGSK.650394EER1.1762e-110.3560image
chr2:61049451-61050944:+LUADGSK269962AEER4.4657e-10-0.2761image
ENSG00000162928.8,PEX13LUADBortezomibEAG1.2759e-09-0.2682image
chr2:61022586-61027348:+LUADJNJ.26854165EER8.8842e-030.4419image
chr2:61022586-61027348:+LUSCAKT.inhibitor.VIIIEER3.4828e-02-0.2168image
chr2:61049451-61050944:+LUSCABT.888EER5.6097e-07-0.2249image
ENSG00000162928.8,PEX13LUSCABT.888EAG2.0698e-07-0.2329image
chr2:61049451-61050944:+MESOBMS.509744EER1.3584e-03-0.3656image
ENSG00000162928.8,PEX13MESOBMS.509744EAG1.3584e-03-0.3656image
chr2:61049451-61050944:+OVBexaroteneEER4.6727e-070.2927image
ENSG00000162928.8,PEX13OVBexaroteneEAG5.6541e-060.2648image
chr2:61022586-61027348:+OVAZ628EER9.9655e-03-0.2866image
ENSG00000162928.8,PEX13PAADLenalidomideEAG2.8001e-030.2320image
chr2:61049451-61050944:+PAADLenalidomideEER2.8001e-030.2320image
chr2:61049451-61050944:+PCPGMidostaurinEER8.8523e-030.2323image
ENSG00000162928.8,PEX13PCPGMidostaurinEAG8.8523e-030.2323image
chr2:61022586-61027348:+PRADJW.7.52.1EER4.2112e-020.4271image
chr2:61049451-61050944:+PRADKU.55933EER2.8779e-15-0.3509image
ENSG00000162928.8,PEX13PRADKU.55933EAG4.0835e-15-0.3487image
ENSG00000162928.8,PEX13READErlotinibEAG1.6174e-020.2529image
chr2:61049451-61050944:+READBIRB.0796EER1.4334e-020.2560image
chr2:61049451-61050944:+SARCAG.014699EER6.9881e-060.3188image
ENSG00000162928.8,PEX13SARCBMS.536924EAG6.6476e-06-0.3187image
chr2:61049451-61050944:+SKCMAZD6244EER1.0027e-04-0.2202image
ENSG00000162928.8,PEX13SKCMAZD6244EAG6.3011e-05-0.2260image
ENSG00000162928.8,PEX13STADCHIR.99021EAG1.4266e-030.1720image
chr2:61049451-61050944:+STADKU.55933EER5.9455e-04-0.1858image
chr2:61022586-61027348:+STADAS601245EER3.2833e-03-0.2249image
ENSG00000162928.8,PEX13TGCTGemcitabineEAG1.5523e-04-0.3359image
chr2:61049451-61050944:+TGCTKIN001.135EER2.0803e-040.3298image
ENSG00000162928.8,PEX13THCAEmbelinEAG2.7798e-380.5386image
chr2:61049451-61050944:+THCAEmbelinEER3.3411e-190.3899image
chr2:61049451-61050944:+THYMEmbelinEER4.8259e-020.2274image
chr2:61049451-61050944:+UCECGefitinibEER9.9261e-03-0.2099image
ENSG00000162928.8,PEX13UCECGDC.0449EAG2.9006e-11-0.5018image
ENSG00000162928.8,PEX13UCSAMG.706EAG2.9646e-04-0.4863image
chr2:61049451-61050944:+UCSFH535EER4.8260e-040.4756image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType