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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: WWOX (ImmuneEditome ID:51741)

1. Gene summary of enriched editing regions for WWOX

check button Gene summary
Gene informationGene symbol

WWOX

Gene ID

51741

GeneSynonymsD16S432E|DEE28|EIEE28|FOR|FRA16D|HHCMA56|PRO0128|SCAR12|SDR41C1|WOX1
GeneCytomap

16q23.1-q23.2

GeneTypeprotein-coding
GeneDescriptionWW domain-containing oxidoreductase|WW domain-containing protein WWOX|fragile site FRA16D oxidoreductase|short chain dehydrogenase/reductase family 41C member 1
GeneModificationdate20230409
UniprotIDH3BMD1;Q9NZC7;A0A087WZG5;F5H3R5;A0A411HBC7;A0A0D9SER1;A0A804HJX9
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr16:78119639-78120515:+ENST00000561846.4ENSG00000186153.15WWOXncRNA_intronicAluYb8,FLAM_Cchr16:78119639-78120515:+.alignment
chr16:78119639-78120515:+ENST00000563358.4ENSG00000186153.15WWOXncRNA_intronicAluYb8,FLAM_Cchr16:78119639-78120515:+.alignment
chr16:78255474-78256092:+ENST00000561846.4ENSG00000186153.15WWOXncRNA_intronicMIR,AluSgchr16:78255474-78256092:+.alignment
chr16:78255474-78256092:+ENST00000562639.4ENSG00000186153.15WWOXncRNA_intronicMIR,AluSgchr16:78255474-78256092:+.alignment
chr16:78255474-78256092:+ENST00000563358.4ENSG00000186153.15WWOXncRNA_intronicMIR,AluSgchr16:78255474-78256092:+.alignment
chr16:78255474-78256092:+ENST00000565791.1ENSG00000186153.15WWOXncRNA_intronicMIR,AluSgchr16:78255474-78256092:+.alignment
chr16:78454556-78455636:+ENST00000402655.5ENSG00000186153.15WWOXintronicAluSx,AluSp,MER96B,L2cchr16:78454556-78455636:+.alignment
chr16:78454556-78455636:+ENST00000406884.5ENSG00000186153.15WWOXintronicAluSx,AluSp,MER96B,L2cchr16:78454556-78455636:+.alignment
chr16:78454556-78455636:+ENST00000408984.6ENSG00000186153.15WWOXintronicAluSx,AluSp,MER96B,L2cchr16:78454556-78455636:+.alignment
chr16:78454556-78455636:+ENST00000539474.5ENSG00000186153.15WWOXintronicAluSx,AluSp,MER96B,L2cchr16:78454556-78455636:+.alignment
chr16:78454556-78455636:+ENST00000566780.4ENSG00000186153.15WWOXintronicAluSx,AluSp,MER96B,L2cchr16:78454556-78455636:+.alignment
chr16:78454556-78455636:+ENST00000569332.4ENSG00000186153.15WWOXintronicAluSx,AluSp,MER96B,L2cchr16:78454556-78455636:+.alignment
chr16:78457655-78458562:+ENST00000402655.5ENSG00000186153.15WWOXintronicAluJb,AluSx1chr16:78457655-78458562:+.alignment
chr16:78457655-78458562:+ENST00000406884.5ENSG00000186153.15WWOXintronicAluJb,AluSx1chr16:78457655-78458562:+.alignment
chr16:78457655-78458562:+ENST00000408984.6ENSG00000186153.15WWOXintronicAluJb,AluSx1chr16:78457655-78458562:+.alignment
chr16:78457655-78458562:+ENST00000539474.5ENSG00000186153.15WWOXintronicAluJb,AluSx1chr16:78457655-78458562:+.alignment
chr16:78457655-78458562:+ENST00000566780.4ENSG00000186153.15WWOXintronicAluJb,AluSx1chr16:78457655-78458562:+.alignment
chr16:78457655-78458562:+ENST00000569332.4ENSG00000186153.15WWOXintronicAluJb,AluSx1chr16:78457655-78458562:+.alignment
chr16:78466224-78466750:+ENST00000402655.5ENSG00000186153.15WWOXintronicL1MB5,AluSx1,AluYchr16:78466224-78466750:+.alignment
chr16:78466224-78466750:+ENST00000406884.5ENSG00000186153.15WWOXintronicL1MB5,AluSx1,AluYchr16:78466224-78466750:+.alignment
chr16:78466224-78466750:+ENST00000408984.6ENSG00000186153.15WWOXintronicL1MB5,AluSx1,AluYchr16:78466224-78466750:+.alignment
chr16:78466224-78466750:+ENST00000539474.5ENSG00000186153.15WWOXintronicL1MB5,AluSx1,AluYchr16:78466224-78466750:+.alignment
chr16:78466224-78466750:+ENST00000566780.4ENSG00000186153.15WWOXintronicL1MB5,AluSx1,AluYchr16:78466224-78466750:+.alignment
chr16:78466224-78466750:+ENST00000569332.4ENSG00000186153.15WWOXintronicL1MB5,AluSx1,AluYchr16:78466224-78466750:+.alignment
chr16:78472527-78473414:+ENST00000402655.5ENSG00000186153.15WWOXintronicAluSz,AluSq2,MER58Bchr16:78472527-78473414:+.alignment
chr16:78472527-78473414:+ENST00000406884.5ENSG00000186153.15WWOXintronicAluSz,AluSq2,MER58Bchr16:78472527-78473414:+.alignment
chr16:78472527-78473414:+ENST00000408984.6ENSG00000186153.15WWOXintronicAluSz,AluSq2,MER58Bchr16:78472527-78473414:+.alignment
chr16:78472527-78473414:+ENST00000539474.5ENSG00000186153.15WWOXintronicAluSz,AluSq2,MER58Bchr16:78472527-78473414:+.alignment
chr16:78472527-78473414:+ENST00000566780.4ENSG00000186153.15WWOXintronicAluSz,AluSq2,MER58Bchr16:78472527-78473414:+.alignment
chr16:78472527-78473414:+ENST00000569332.4ENSG00000186153.15WWOXintronicAluSz,AluSq2,MER58Bchr16:78472527-78473414:+.alignment
chr16:78570359-78570623:+ENST00000402655.5ENSG00000186153.15WWOXintronicAluJochr16:78570359-78570623:+.alignment
chr16:78570359-78570623:+ENST00000406884.5ENSG00000186153.15WWOXintronicAluJochr16:78570359-78570623:+.alignment
chr16:78570359-78570623:+ENST00000408984.6ENSG00000186153.15WWOXintronicAluJochr16:78570359-78570623:+.alignment
chr16:78570359-78570623:+ENST00000539474.5ENSG00000186153.15WWOXintronicAluJochr16:78570359-78570623:+.alignment
chr16:78570359-78570623:+ENST00000566780.4ENSG00000186153.15WWOXintronicAluJochr16:78570359-78570623:+.alignment
chr16:78570359-78570623:+ENST00000569332.4ENSG00000186153.15WWOXintronicAluJochr16:78570359-78570623:+.alignment
chr16:78643941-78644746:+ENST00000402655.5ENSG00000186153.15WWOXintronicAluSq,AluSp,(AATG)nchr16:78643941-78644746:+.alignment
chr16:78643941-78644746:+ENST00000406884.5ENSG00000186153.15WWOXintronicAluSq,AluSp,(AATG)nchr16:78643941-78644746:+.alignment
chr16:78643941-78644746:+ENST00000408984.6ENSG00000186153.15WWOXintronicAluSq,AluSp,(AATG)nchr16:78643941-78644746:+.alignment
chr16:78643941-78644746:+ENST00000539474.5ENSG00000186153.15WWOXintronicAluSq,AluSp,(AATG)nchr16:78643941-78644746:+.alignment
chr16:78643941-78644746:+ENST00000566780.4ENSG00000186153.15WWOXintronicAluSq,AluSp,(AATG)nchr16:78643941-78644746:+.alignment
chr16:78643941-78644746:+ENST00000569332.4ENSG00000186153.15WWOXintronicAluSq,AluSp,(AATG)nchr16:78643941-78644746:+.alignment
chr16:78665753-78666238:+ENST00000402655.5ENSG00000186153.15WWOXintronicMLT1I,AluJb,AluSzchr16:78665753-78666238:+.alignment
chr16:78665753-78666238:+ENST00000406884.5ENSG00000186153.15WWOXintronicMLT1I,AluJb,AluSzchr16:78665753-78666238:+.alignment
chr16:78665753-78666238:+ENST00000408984.6ENSG00000186153.15WWOXintronicMLT1I,AluJb,AluSzchr16:78665753-78666238:+.alignment
chr16:78665753-78666238:+ENST00000539474.5ENSG00000186153.15WWOXintronicMLT1I,AluJb,AluSzchr16:78665753-78666238:+.alignment
chr16:78665753-78666238:+ENST00000566780.4ENSG00000186153.15WWOXintronicMLT1I,AluJb,AluSzchr16:78665753-78666238:+.alignment
chr16:78665753-78666238:+ENST00000569332.4ENSG00000186153.15WWOXintronicMLT1I,AluJb,AluSzchr16:78665753-78666238:+.alignment
chr16:78736667-78736878:+ENST00000402655.5ENSG00000186153.15WWOXintronicAluJochr16:78736667-78736878:+.alignment
chr16:78736667-78736878:+ENST00000406884.5ENSG00000186153.15WWOXintronicAluJochr16:78736667-78736878:+.alignment
chr16:78736667-78736878:+ENST00000408984.6ENSG00000186153.15WWOXintronicAluJochr16:78736667-78736878:+.alignment
chr16:78736667-78736878:+ENST00000539474.5ENSG00000186153.15WWOXintronicAluJochr16:78736667-78736878:+.alignment
chr16:78736667-78736878:+ENST00000566780.4ENSG00000186153.15WWOXintronicAluJochr16:78736667-78736878:+.alignment
chr16:78736667-78736878:+ENST00000569332.4ENSG00000186153.15WWOXintronicAluJochr16:78736667-78736878:+.alignment
chr16:78752378-78753720:+ENST00000402655.5ENSG00000186153.15WWOXintronicAluY,MIRb,L4_C_Mam,AluSx,AluJbchr16:78752378-78753720:+.alignment
chr16:78752378-78753720:+ENST00000406884.5ENSG00000186153.15WWOXintronicAluY,MIRb,L4_C_Mam,AluSx,AluJbchr16:78752378-78753720:+.alignment
chr16:78752378-78753720:+ENST00000408984.6ENSG00000186153.15WWOXintronicAluY,MIRb,L4_C_Mam,AluSx,AluJbchr16:78752378-78753720:+.alignment
chr16:78752378-78753720:+ENST00000539474.5ENSG00000186153.15WWOXintronicAluY,MIRb,L4_C_Mam,AluSx,AluJbchr16:78752378-78753720:+.alignment
chr16:78752378-78753720:+ENST00000566780.4ENSG00000186153.15WWOXintronicAluY,MIRb,L4_C_Mam,AluSx,AluJbchr16:78752378-78753720:+.alignment
chr16:78752378-78753720:+ENST00000569332.4ENSG00000186153.15WWOXintronicAluY,MIRb,L4_C_Mam,AluSx,AluJbchr16:78752378-78753720:+.alignment
chr16:78785999-78787021:+ENST00000402655.5ENSG00000186153.15WWOXintronicL1MB5,L1MB8,MER63C,AluSx1chr16:78785999-78787021:+.alignment
chr16:78785999-78787021:+ENST00000406884.5ENSG00000186153.15WWOXintronicL1MB5,L1MB8,MER63C,AluSx1chr16:78785999-78787021:+.alignment
chr16:78785999-78787021:+ENST00000539474.5ENSG00000186153.15WWOXintronicL1MB5,L1MB8,MER63C,AluSx1chr16:78785999-78787021:+.alignment
chr16:78785999-78787021:+ENST00000566780.4ENSG00000186153.15WWOXintronicL1MB5,L1MB8,MER63C,AluSx1chr16:78785999-78787021:+.alignment
chr16:78785999-78787021:+ENST00000569332.4ENSG00000186153.15WWOXintronicL1MB5,L1MB8,MER63C,AluSx1chr16:78785999-78787021:+.alignment
chr16:78790157-78790961:+ENST00000402655.5ENSG00000186153.15WWOXintronicAluJb,AluSzchr16:78790157-78790961:+.alignment
chr16:78790157-78790961:+ENST00000406884.5ENSG00000186153.15WWOXintronicAluJb,AluSzchr16:78790157-78790961:+.alignment
chr16:78790157-78790961:+ENST00000539474.5ENSG00000186153.15WWOXintronicAluJb,AluSzchr16:78790157-78790961:+.alignment
chr16:78790157-78790961:+ENST00000566780.4ENSG00000186153.15WWOXintronicAluJb,AluSzchr16:78790157-78790961:+.alignment
chr16:78790157-78790961:+ENST00000569332.4ENSG00000186153.15WWOXintronicAluJb,AluSzchr16:78790157-78790961:+.alignment
chr16:78797012-78797890:+ENST00000402655.5ENSG00000186153.15WWOXintronicA-rich,AluJr,MIRc,AluSzchr16:78797012-78797890:+.alignment
chr16:78797012-78797890:+ENST00000406884.5ENSG00000186153.15WWOXintronicA-rich,AluJr,MIRc,AluSzchr16:78797012-78797890:+.alignment
chr16:78797012-78797890:+ENST00000539474.5ENSG00000186153.15WWOXintronicA-rich,AluJr,MIRc,AluSzchr16:78797012-78797890:+.alignment
chr16:78797012-78797890:+ENST00000566780.4ENSG00000186153.15WWOXintronicA-rich,AluJr,MIRc,AluSzchr16:78797012-78797890:+.alignment
chr16:78797012-78797890:+ENST00000569332.4ENSG00000186153.15WWOXintronicA-rich,AluJr,MIRc,AluSzchr16:78797012-78797890:+.alignment
chr16:78802626-78803736:+ENST00000402655.5ENSG00000186153.15WWOXintronicAluJo,AluSx1chr16:78802626-78803736:+.alignment
chr16:78802626-78803736:+ENST00000406884.5ENSG00000186153.15WWOXintronicAluJo,AluSx1chr16:78802626-78803736:+.alignment
chr16:78802626-78803736:+ENST00000539474.5ENSG00000186153.15WWOXintronicAluJo,AluSx1chr16:78802626-78803736:+.alignment
chr16:78802626-78803736:+ENST00000566780.4ENSG00000186153.15WWOXintronicAluJo,AluSx1chr16:78802626-78803736:+.alignment
chr16:78802626-78803736:+ENST00000569332.4ENSG00000186153.15WWOXintronicAluJo,AluSx1chr16:78802626-78803736:+.alignment
chr16:78860860-78861284:+ENST00000402655.5ENSG00000186153.15WWOXintronic(CTTT)n,(CCTG)n,MLT2B4,AluJbchr16:78860860-78861284:+.alignment
chr16:78860860-78861284:+ENST00000406884.5ENSG00000186153.15WWOXintronic(CTTT)n,(CCTG)n,MLT2B4,AluJbchr16:78860860-78861284:+.alignment
chr16:78860860-78861284:+ENST00000539474.5ENSG00000186153.15WWOXintronic(CTTT)n,(CCTG)n,MLT2B4,AluJbchr16:78860860-78861284:+.alignment
chr16:78860860-78861284:+ENST00000566780.4ENSG00000186153.15WWOXintronic(CTTT)n,(CCTG)n,MLT2B4,AluJbchr16:78860860-78861284:+.alignment
chr16:78860860-78861284:+ENST00000569332.4ENSG00000186153.15WWOXintronic(CTTT)n,(CCTG)n,MLT2B4,AluJbchr16:78860860-78861284:+.alignment
chr16:78882521-78884227:+ENST00000402655.5ENSG00000186153.15WWOXintronicL1ME3A,L1MD3,AluSz6,AluJb,AluSzchr16:78882521-78884227:+.alignment
chr16:78882521-78884227:+ENST00000406884.5ENSG00000186153.15WWOXintronicL1ME3A,L1MD3,AluSz6,AluJb,AluSzchr16:78882521-78884227:+.alignment
chr16:78882521-78884227:+ENST00000539474.5ENSG00000186153.15WWOXintronicL1ME3A,L1MD3,AluSz6,AluJb,AluSzchr16:78882521-78884227:+.alignment
chr16:78882521-78884227:+ENST00000566780.4ENSG00000186153.15WWOXintronicL1ME3A,L1MD3,AluSz6,AluJb,AluSzchr16:78882521-78884227:+.alignment
chr16:78882521-78884227:+ENST00000569332.4ENSG00000186153.15WWOXintronicL1ME3A,L1MD3,AluSz6,AluJb,AluSzchr16:78882521-78884227:+.alignment
chr16:78933546-78934473:+ENST00000402655.5ENSG00000186153.15WWOXintronicTHE1B,AluY,AluJr4chr16:78933546-78934473:+.alignment
chr16:78933546-78934473:+ENST00000406884.5ENSG00000186153.15WWOXintronicTHE1B,AluY,AluJr4chr16:78933546-78934473:+.alignment
chr16:78933546-78934473:+ENST00000539474.5ENSG00000186153.15WWOXintronicTHE1B,AluY,AluJr4chr16:78933546-78934473:+.alignment
chr16:78933546-78934473:+ENST00000566780.4ENSG00000186153.15WWOXintronicTHE1B,AluY,AluJr4chr16:78933546-78934473:+.alignment
chr16:78933546-78934473:+ENST00000569332.4ENSG00000186153.15WWOXintronicTHE1B,AluY,AluJr4chr16:78933546-78934473:+.alignment


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2. Tumor-specific enriched editing regions for WWOX


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
ENSG00000186153.15,WWOXTHCAEAG2.9761e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000186153.15,WWOXESCACliEAG3.5343e-033.6819e-030.4986image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
ENSG00000186153.15,WWOXBRCAEAG6.5341e-036.2521e-032.0373e-04image

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3. Enriched editing regions and immune related genes for WWOX


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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4. Enriched editing regions and immune related splicing for WWOX


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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5. Enriched editing regions and immune infiltration for WWOX


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000186153.15,WWOXBLCAEAGPlasma_cells1.0757e-020.4664image
ENSG00000186153.15,WWOXBRCAEAGT_cells_CD4_memory_resting1.5753e-020.1732image
ENSG00000186153.15,WWOXCESCEAGMonocytes4.5513e-030.4504image
ENSG00000186153.15,WWOXCOADEAGDendritic_cells_activated1.8805e-030.6375image
chr16:78119639-78120515:+ESCAEERNK_cells_resting1.0001e-02-0.4357image
chr16:78454556-78455636:+ESCAEERT_cells_follicular_helper2.2327e-03-0.6295image
chr16:78472527-78473414:+ESCAEERMacrophages_M01.3772e-020.5285image
ENSG00000186153.15,WWOXHNSCEAGT_cells_regulatory_(Tregs)1.2689e-040.6614image
ENSG00000186153.15,WWOXKIRCEAGDendritic_cells_resting2.7964e-020.3520image
ENSG00000186153.15,WWOXKIRPEAGMacrophages_M17.1360e-030.5243image
ENSG00000186153.15,WWOXLAMLEAGEosinophils3.4075e-02-0.2451image
ENSG00000186153.15,WWOXLUADEAGNeutrophils2.8965e-040.5435image
ENSG00000186153.15,WWOXLUSCEAGT_cells_CD83.1717e-020.2589image
chr16:78933546-78934473:+OVEERB_cells_memory4.8127e-02-0.3991image
ENSG00000186153.15,WWOXOVEAGT_cells_CD84.6893e-020.2384image
ENSG00000186153.15,WWOXPRADEAGT_cells_regulatory_(Tregs)4.6900e-020.2124image
chr16:78472527-78473414:+STADEERB_cells_memory1.2208e-030.3984image
chr16:78752378-78753720:+STADEERMacrophages_M26.0457e-030.4819image
chr16:78790157-78790961:+STADEERDendritic_cells_activated7.2943e-040.5242image
chr16:78933546-78934473:+STADEERMonocytes2.7822e-020.3523image
ENSG00000186153.15,WWOXSTADEAGMacrophages_M23.0929e-030.2170image
ENSG00000186153.15,WWOXTHCAEAGDendritic_cells_resting8.2926e-030.3008image


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6. Enriched editing regions and immune gene sets for WWOX


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000186153.15,WWOXBRCAGSVA_HALLMARK_MYOGENESISEAG4.6825e-020.1429image
ENSG00000186153.15,WWOXCOADGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG3.5700e-020.4604image
chr16:78119639-78120515:+ESCAGSVA_HALLMARK_MITOTIC_SPINDLEEER6.5840e-03-0.4570image
chr16:78472527-78473414:+ESCAGSVA_HALLMARK_SPERMATOGENESISEER1.3092e-02-0.5318image
chr16:78802626-78803736:+ESCAGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER3.0358e-02-0.4097image
chr16:78933546-78934473:+ESCAGSVA_HALLMARK_BILE_ACID_METABOLISMEER3.8382e-020.4006image
ENSG00000186153.15,WWOXESCAGSVA_HALLMARK_ANDROGEN_RESPONSEEAG2.2349e-02-0.2367image
ENSG00000186153.15,WWOXGBMGSVA_HALLMARK_MITOTIC_SPINDLEEAG9.6604e-03-0.5508image
ENSG00000186153.15,WWOXKIRCGSVA_HALLMARK_E2F_TARGETSEAG1.8637e-020.3751image
ENSG00000186153.15,WWOXKIRPGSVA_HALLMARK_UV_RESPONSE_DNEAG3.4193e-020.4250image
ENSG00000186153.15,WWOXLAMLGSVA_HALLMARK_NOTCH_SIGNALINGEAG9.1434e-030.2991image
ENSG00000186153.15,WWOXLGGGSVA_HALLMARK_SPERMATOGENESISEAG4.1672e-020.1718image
ENSG00000186153.15,WWOXLUADGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.3109e-02-0.3890image
ENSG00000186153.15,WWOXLUSCGSVA_HALLMARK_MYC_TARGETS_V1EAG3.0121e-020.2613image
chr16:78933546-78934473:+OVGSVA_HALLMARK_HEME_METABOLISMEER3.7416e-030.5581image
ENSG00000186153.15,WWOXOVGSVA_HALLMARK_IL2_STAT5_SIGNALINGEAG1.9828e-030.3635image
ENSG00000186153.15,WWOXPRADGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG2.3274e-020.2417image
chr16:78454556-78455636:+STADGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER2.7910e-020.3110image
chr16:78802626-78803736:+STADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER4.5804e-040.4254image
chr16:78933546-78934473:+STADGSVA_HALLMARK_IL2_STAT5_SIGNALINGEER2.7828e-020.3523image
chr16:78882521-78884227:+STADGSVA_HALLMARK_ADIPOGENESISEER1.5755e-020.4443image
ENSG00000186153.15,WWOXSTADGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG3.4537e-030.2145image
chr16:78457655-78458562:+STADGSVA_HALLMARK_FATTY_ACID_METABOLISMEER2.8526e-020.3303image
ENSG00000186153.15,WWOXTHCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG1.3865e-040.4234image


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7. Enriched editing regions and drugs for WWOX


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000186153.15,WWOXBLCADocetaxelEAG4.1321e-020.3812image
ENSG00000186153.15,WWOXBRCAAZD.0530EAG1.3129e-02-0.1783image
ENSG00000186153.15,WWOXCOADLFM.A13EAG8.5542e-04-0.6717image
chr16:78119639-78120515:+ESCABAY.61.3606EER1.7800e-020.4040image
chr16:78472527-78473414:+ESCAAZD6244EER3.5971e-04-0.7049image
ENSG00000186153.15,WWOXGBMAxitinibEAG1.0669e-030.6625image
ENSG00000186153.15,WWOXHNSCAZD6244EAG5.8493e-03-0.5162image
ENSG00000186153.15,WWOXKIRPBX.795EAG1.0094e-02-0.5046image
ENSG00000186153.15,WWOXLAMLCI.1040EAG1.2718e-02-0.2865image
ENSG00000186153.15,WWOXLUADGW843682XEAG1.6225e-020.3778image
ENSG00000186153.15,WWOXLUSCLFM.A13EAG2.2259e-020.2749image
chr16:78933546-78934473:+OVBI.2536EER1.0189e-020.5041image
ENSG00000186153.15,WWOXOVCI.1040EAG2.4792e-03-0.3561image
ENSG00000186153.15,WWOXPRADFTI.277EAG3.7478e-030.3059image
chr16:78454556-78455636:+STADBIBW2992EER1.1959e-04-0.5173image
chr16:78790157-78790961:+STADCCT018159EER1.1296e-020.4066image
chr16:78472527-78473414:+STADBosutinibEER4.1962e-03-0.3559image
chr16:78882521-78884227:+STADA.443654EER2.1913e-02-0.4239image
ENSG00000186153.15,WWOXSTADCI.1040EAG4.9877e-03-0.2062image
chr16:78457655-78458562:+STADAZD6482EER9.9272e-030.3847image
ENSG00000186153.15,WWOXTHCALapatinibEAG2.4515e-03-0.3426image
ENSG00000186153.15,WWOXTHYMDasatinibEAG1.1870e-020.5506image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType