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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: NGRN (ImmuneEditome ID:51335)

1. Gene summary of enriched editing regions for NGRN

check button Gene summary
Gene informationGene symbol

NGRN

Gene ID

51335

GeneSynonymsDSC92
GeneCytomap

15q26.1

GeneTypeprotein-coding
GeneDescriptionneugrin|mesenchymal stem cell protein DSC92|neurite outgrowth associated protein|spinal cord-derived protein FI58G
GeneModificationdate20230329
UniprotIDQ9NPE2;A0A087WWE0
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr15:90272512-90275079:+ENST00000331497.3ENSG00000182768.8NGRNncRNA_exonicAluSx1,AluSx,(TATTGT)n,FRAM,MIRc,AluSzchr15:90272512-90275079:+.alignment
chr15:90276136-90277781:+ENST00000379095.4ENSG00000182768.8NGRNUTR3AluSx,AluYchr15:90276136-90277781:+.alignment


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2. Tumor-specific enriched editing regions for NGRN


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr15:90272512-90275079:+BRCAEER3.1412e-02image
chr15:90276136-90277781:+BRCAEER1.0911e-02image
ENSG00000182768.8,NGRNBRCAEAG7.1875e-04image
chr15:90276136-90277781:+KIRCEER1.0733e-02image
ENSG00000182768.8,NGRNKIRCEAG5.3095e-03image
chr15:90276136-90277781:+KIRPEER2.3268e-02image
ENSG00000182768.8,NGRNKIRPEAG1.3651e-02image
chr15:90276136-90277781:+LUSCEER5.7115e-03image
ENSG00000182768.8,NGRNLUSCEAG2.0965e-03image
ENSG00000182768.8,NGRNPRADEAG2.6948e-02image
chr15:90272512-90275079:+THCAEER2.4339e-04image
chr15:90276136-90277781:+THCAEER6.4460e-05image
ENSG00000182768.8,NGRNTHCAEAG1.2086e-05image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000182768.8,NGRNKIRPPathEAG1.4453e-026.8646e-030.1925image
chr15:90276136-90277781:+KIRPPathEER1.1931e-025.5782e-030.1983image
ENSG00000182768.8,NGRNPAADPathEAG9.9644e-051.4642e-020.2233image
chr15:90272512-90275079:+PAADPathEER1.3094e-027.0830e-030.3918image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr15:90272512-90275079:+BRCAEER3.7619e-023.3553e-024.2445e-02image
chr15:90276136-90277781:+KIRPEER2.1660e-046.8871e-042.7701e+02image
ENSG00000182768.8,NGRNKIRPEAG7.3206e-048.9639e-042.5775e+02image

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3. Enriched editing regions and immune related genes for NGRN


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr15:90272512-90275079:+GBMEERENSG00000267565,CTC-559E9.8-0.51711.1544e-061.8219e-09-0.4903imageNNNAMonocytesGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr15:90272512-90275079:+GBMEERENSG00000119655,NPC20.52081.2462e-064.3876e-090.4800imageNDGCR8;EIF4A3;FUS;NOP58NAMonocytesGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr15:90272512-90275079:+GBMEERENSG00000186300,ZNF555-0.51591.3752e-062.4655e-09-0.4868imageNDGCR8;EIF4A3;FUS;NOP58NAMonocytesGSVA_HALLMARK_XENOBIOTIC_METABOLISM
chr15:90272512-90275079:+GBMEERENSG00000086475,SEPHS1-0.50622.2587e-069.3556e-07-0.4089imageNDGCR8;EIF4A3;FUS;NOP58NAMonocytesGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALING
chr15:90272512-90275079:+GBMEERENSG00000143110,C1orf1620.51042.3069e-066.6046e-130.5699imageNFUS;NOP58NAMonocytesGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr15:90272512-90275079:+GBMEERENSG00000147180,ZNF711-0.48697.3033e-061.2838e-07-0.4372imageNDGCR8;EIF4A3;FUS;NOP58NAT_cells_follicular_helperGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr15:90272512-90275079:+GBMEERENSG00000197020,ZNF100-0.47431.5594e-053.7447e-08-0.4535imageNDGCR8;EIF4A3;FUS;NOP58NAMonocytesGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr15:90272512-90275079:+GBMEERENSG00000197124,ZNF682-0.47591.7347e-056.1886e-07-0.4150imageNDGCR8;EIF4A3;FUS;NOP58NAT_cells_follicular_helperGSVA_HALLMARK_XENOBIOTIC_METABOLISM
chr15:90272512-90275079:+GBMEERENSG00000110987,BCL7A-0.46921.9191e-058.8832e-07-0.4096imageNDGCR8;EIF4A3;FUS;NOP58BCL7AMonocytesGSVA_HALLMARK_COAGULATION
chr15:90272512-90275079:+GBMEERENSG00000166340,TPP10.47111.9285e-058.3247e-090.4723imageNDGCR8;EIF4A3;FUS;NOP58NAT_cells_CD4_memory_activatedGSVA_HALLMARK_COMPLEMENT
chr15:90276136-90277781:+UCECEERENSG00000111058,ACSS30.31232.9169e-022.7332e-060.4024imageNDKC1NAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr15:90276136-90277781:+KIRPEERENSG00000120063,GNA130.39157.9844e-071.5074e-130.4768imageNDKC1GNA13B_cells_naiveGSVA_HALLMARK_UV_RESPONSE_DN
chr15:90276136-90277781:+KIRPEERENSG00000266469,CTB-131K11.10.35401.0613e-052.6100e-100.4148imageNDKC1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
chr15:90276136-90277781:+KIRPEERENSG00000062725,APPBP20.32775.2623e-059.4255e-110.4241imageNDKC1NAB_cells_naiveGSVA_HALLMARK_MITOTIC_SPINDLE
chr15:90276136-90277781:+KIRPEERENSG00000040275,SPDL10.17644.6304e-023.9656e-100.4110imageNDKC1NAMacrophages_M1GSVA_HALLMARK_G2M_CHECKPOINT

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4. Enriched editing regions and immune related splicing for NGRN


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr15:90272512-90275079:+
GBMEERMEXENSG00000071564.10chr191611805:1611849:1611990:1612430:1615423:1615485:1615685:16157410.34884.3070e-035.9348e-060.4049imageNDGCR8;EIF4A3;FUS;NOP58TCF3GSVA_HALLMARK_APOPTOSIS
chr15:90272512-90275079:+
GBMEERESENSG00000198814.8chrX30696616:30696683:30697731:30697749:30700413:30700449-0.35384.4742e-032.4548e-06-0.4198imageNDGCR8;EIF4A3;FUS;NOP58NAMast_cells_restingGSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr15:90272512-90275079:+
GBMEERA5ENSG00000102710.15chr1337009616:37009809:37012191:37012297:37010551:370122970.41231.4438e-031.6035e-060.4007imageNDGCR8;EIF4A3;FUS;NOP58NAMonocytesGSVA_HALLMARK_BILE_ACID_METABOLISM
chr15:90272512-90275079:+
GBMEERA3ENSG00000115355.11chr255291675:55291775:55288177:55288355:55288177:552911640.40812.5270e-031.1986e-060.4052imageNDGCR8;EIF4A3;FUS;NOP58CCDC88AMonocytesGSVA_HALLMARK_MITOTIC_SPINDLE
chr15:90272512-90275079:+
GBMEERIRENSG00000025434.14chr1147261240:47261449:47261546:47261726-0.49425.2012e-051.4302e-06-0.4025imageNDGCR8;EIF4A3;FUS;NOP58NR1H3T_cells_follicular_helperGSVA_HALLMARK_COMPLEMENT
chr15:90272512-90275079:+
GBMEERIRENSG00000204634.8chr2101010928:101011026:101011450:101011540-0.37816.5997e-041.3859e-05-0.4031imageNDGCR8;EIF4A3;FUS;NOP58NAT_cells_CD4_memory_activatedGSVA_HALLMARK_COAGULATION
chr15:90272512-90275079:+
GBMEERMEXENSG00000185049.8chr41989707:1989869:1991543:1991709:2006997:2007199:2008749:2008835-0.32991.7747e-025.7743e-09-0.4767imageNDGCR8;EIF4A3;FUS;NOP58NANK_cells_activatedGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr15:90272512-90275079:+
GBMEERMEXENSG00000185049.8chr41989707:1989869:1991543:1991730:2006997:2007199:2008749:2008835-0.32721.9511e-028.9262e-09-0.4715imageNDGCR8;EIF4A3;FUS;NOP58NANK_cells_activatedGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr15:90272512-90275079:+
GBMEERA5ENSG00000077809.8chr774728785:74728896:74716893:74716950:74716893:747189410.42061.2241e-031.3404e-060.4035imageNNNAMonocytesGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr15:90272512-90275079:+
GBMEERA5ENSG00000040933.11chr298559462:98559495:98555552:98555691:98555552:98555808-0.34983.8477e-033.3502e-06-0.4130imageNDGCR8;EIF4A3;FUS;NOP58NAMonocytesGSVA_HALLMARK_ALLOGRAFT_REJECTION

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5. Enriched editing regions and immune infiltration for NGRN


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr15:90276136-90277781:+ACCEERT_cells_CD4_memory_activated1.0075e-020.3572image
ENSG00000182768.8,NGRNACCEAGT_cells_CD4_memory_activated1.1020e-020.3532image
chr15:90272512-90275079:+BLCAEERDendritic_cells_activated3.9542e-020.2307image
chr15:90272512-90275079:+BRCAEERT_cells_follicular_helper1.0387e-020.0990image
chr15:90276136-90277781:+BRCAEERNK_cells_activated1.3869e-04-0.1226image
ENSG00000182768.8,NGRNBRCAEAGNK_cells_activated7.4246e-05-0.1259image
chr15:90276136-90277781:+CESCEERMonocytes5.1995e-03-0.1931image
ENSG00000182768.8,NGRNCESCEAGMonocytes4.1784e-03-0.1974image
chr15:90276136-90277781:+CHOLEERNK_cells_activated3.7176e-040.6669image
ENSG00000182768.8,NGRNCHOLEAGT_cells_gamma_delta2.5070e-040.6591image
chr15:90276136-90277781:+COADEERNeutrophils3.2038e-020.1603image
chr15:90272512-90275079:+ESCAEERDendritic_cells_resting1.5690e-02-0.1932image
chr15:90276136-90277781:+ESCAEERT_cells_CD85.7647e-030.2230image
ENSG00000182768.8,NGRNESCAEAGT_cells_CD88.8493e-040.2620image
chr15:90272512-90275079:+GBMEERT_cells_CD4_memory_activated7.9716e-080.4436image
chr15:90276136-90277781:+GBMEERMacrophages_M02.0117e-05-0.3282image
ENSG00000182768.8,NGRNGBMEAGMacrophages_M05.0541e-05-0.3128image
chr15:90272512-90275079:+HNSCEERNK_cells_resting5.1989e-050.2985image
chr15:90276136-90277781:+HNSCEERNK_cells_resting5.2201e-040.1866image
ENSG00000182768.8,NGRNHNSCEAGNK_cells_resting9.0187e-050.2060image
chr15:90276136-90277781:+KICHEEREosinophils1.9869e-020.3221image
ENSG00000182768.8,NGRNKICHEAGT_cells_CD4_memory_resting3.1570e-020.2930image
chr15:90276136-90277781:+KIRCEERMacrophages_M21.5150e-030.1806image
ENSG00000182768.8,NGRNKIRCEAGMacrophages_M24.3805e-040.1966image
chr15:90272512-90275079:+KIRPEERMast_cells_resting7.4232e-030.2902image
chr15:90276136-90277781:+KIRPEERT_cells_CD4_memory_activated2.9591e-030.2022image
ENSG00000182768.8,NGRNKIRPEAGT_cells_CD4_memory_activated2.5760e-030.2041image
ENSG00000182768.8,NGRNLAMLEAGNK_cells_resting3.0631e-020.4419image
chr15:90272512-90275079:+LGGEERMacrophages_M26.9696e-030.1294image
chr15:90276136-90277781:+LGGEERT_cells_CD4_memory_activated7.1129e-030.1179image
ENSG00000182768.8,NGRNLGGEAGT_cells_CD4_memory_activated2.5143e-030.1321image
chr15:90276136-90277781:+LIHCEERT_cells_gamma_delta1.8398e-02-0.1990image
ENSG00000182768.8,NGRNLIHCEAGT_cells_gamma_delta2.8264e-02-0.1828image
chr15:90272512-90275079:+LUSCEERPlasma_cells2.6718e-02-0.1351image
chr15:90276136-90277781:+LUSCEERB_cells_naive4.0812e-04-0.1729image
ENSG00000182768.8,NGRNLUSCEAGB_cells_naive5.5047e-04-0.1689image
chr15:90276136-90277781:+MESOEERNK_cells_activated4.7970e-03-0.3182image
ENSG00000182768.8,NGRNMESOEAGNK_cells_activated6.4916e-03-0.3077image
chr15:90272512-90275079:+OVEERT_cells_gamma_delta6.2351e-060.3126image
chr15:90276136-90277781:+OVEERB_cells_memory4.6204e-03-0.1815image
ENSG00000182768.8,NGRNOVEAGT_cells_gamma_delta2.8995e-030.1858image
chr15:90272512-90275079:+PAADEERB_cells_naive2.4915e-02-0.3304image
ENSG00000182768.8,NGRNPAADEAGB_cells_naive4.4499e-02-0.1838image
chr15:90272512-90275079:+PCPGEERMast_cells_activated5.7842e-030.2372image
chr15:90276136-90277781:+PCPGEERMacrophages_M11.3089e-030.2418image
ENSG00000182768.8,NGRNPCPGEAGMacrophages_M13.2861e-020.1619image
chr15:90276136-90277781:+PRADEERNK_cells_activated8.0714e-030.1283image
ENSG00000182768.8,NGRNPRADEAGNK_cells_activated6.9961e-030.1299image
chr15:90272512-90275079:+READEERNK_cells_resting1.0826e-020.3939image
chr15:90276136-90277781:+READEERB_cells_memory1.1717e-020.2916image
ENSG00000182768.8,NGRNREADEAGB_cells_memory4.9898e-030.3210image
chr15:90276136-90277781:+SARCEERPlasma_cells2.5173e-02-0.1492image
ENSG00000182768.8,NGRNSARCEAGPlasma_cells2.6275e-02-0.1469image
chr15:90272512-90275079:+SKCMEERT_cells_CD87.7301e-050.2633image
chr15:90276136-90277781:+SKCMEERT_cells_CD83.7465e-040.1820image
ENSG00000182768.8,NGRNSKCMEAGT_cells_CD89.7548e-040.1678image
chr15:90272512-90275079:+STADEERT_cells_CD4_memory_activated3.0295e-020.1255image
ENSG00000182768.8,NGRNSTADEAGT_cells_CD4_memory_activated4.7671e-020.1126image
chr15:90272512-90275079:+TGCTEERMacrophages_M04.6617e-020.4285image
chr15:90276136-90277781:+TGCTEERT_cells_CD4_memory_activated1.9955e-030.4151image
ENSG00000182768.8,NGRNTGCTEAGT_cells_CD4_memory_activated1.8642e-030.4139image
chr15:90272512-90275079:+THCAEERB_cells_naive4.6789e-030.1809image
chr15:90276136-90277781:+THCAEERMacrophages_M21.2793e-02-0.1155image
ENSG00000182768.8,NGRNTHCAEAGB_cells_naive1.0891e-020.1180image
chr15:90276136-90277781:+THYMEERT_cells_CD4_memory_activated2.8213e-020.2470image
ENSG00000182768.8,NGRNTHYMEAGT_cells_CD4_memory_activated7.3742e-030.2993image
chr15:90272512-90275079:+UCECEERMast_cells_resting1.1635e-020.4870image
chr15:90276136-90277781:+UCECEERNeutrophils1.0651e-020.2259image
ENSG00000182768.8,NGRNUCECEAGNeutrophils9.6533e-030.2280image
chr15:90276136-90277781:+UVMEERDendritic_cells_activated1.4432e-050.6344image
ENSG00000182768.8,NGRNUVMEAGNeutrophils1.0416e-040.5813image


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6. Enriched editing regions and immune gene sets for NGRN


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000182768.8,NGRNACCGSVA_HALLMARK_HEME_METABOLISMEAG6.3335e-030.3774image
chr15:90276136-90277781:+ACCGSVA_HALLMARK_HEME_METABOLISMEER6.9114e-030.3737image
ENSG00000182768.8,NGRNBLCAGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.6665e-040.2284image
chr15:90276136-90277781:+BLCAGSVA_HALLMARK_UV_RESPONSE_DNEER2.4907e-040.2236image
chr15:90272512-90275079:+BLCAGSVA_HALLMARK_KRAS_SIGNALING_DNEER8.3758e-030.2929image
chr15:90276136-90277781:+BRCAGSVA_HALLMARK_MITOTIC_SPINDLEEER1.9831e-150.2524image
chr15:90272512-90275079:+BRCAGSVA_HALLMARK_P53_PATHWAYEER6.5889e-050.1535image
ENSG00000182768.8,NGRNBRCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.0512e-170.2660image
ENSG00000182768.8,NGRNCESCGSVA_HALLMARK_APOPTOSISEAG7.1041e-030.1857image
chr15:90276136-90277781:+CESCGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER6.1564e-030.1894image
ENSG00000182768.8,NGRNCHOLGSVA_HALLMARK_DNA_REPAIREAG4.2213e-02-0.4012image
chr15:90276136-90277781:+COADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER4.6468e-040.2590image
ENSG00000182768.8,NGRNCOADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG3.2737e-030.2146image
chr15:90272512-90275079:+COADGSVA_HALLMARK_PEROXISOMEEER1.4502e-02-0.2794image
chr15:90276136-90277781:+ESCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.6723e-040.3007image
chr15:90272512-90275079:+ESCAGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER1.7555e-02-0.1899image
ENSG00000182768.8,NGRNESCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG2.7547e-030.2367image
chr15:90272512-90275079:+GBMGSVA_HALLMARK_COAGULATIONEER4.2614e-070.4204image
ENSG00000182768.8,NGRNGBMGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG5.2505e-080.4117image
chr15:90276136-90277781:+GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.5861e-080.4202image
chr15:90272512-90275079:+HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.2227e-030.2405image
ENSG00000182768.8,NGRNHNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.3510e-050.2180image
chr15:90276136-90277781:+HNSCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER4.5901e-050.2185image
chr15:90276136-90277781:+KICHGSVA_HALLMARK_PROTEIN_SECRETIONEER1.8140e-02-0.3266image
ENSG00000182768.8,NGRNKICHGSVA_HALLMARK_KRAS_SIGNALING_DNEAG3.6660e-020.2851image
chr15:90276136-90277781:+KIRCGSVA_HALLMARK_MITOTIC_SPINDLEEER5.1349e-070.2823image
ENSG00000182768.8,NGRNKIRCGSVA_HALLMARK_PROTEIN_SECRETIONEAG5.2738e-060.2530image
chr15:90276136-90277781:+KIRPGSVA_HALLMARK_PROTEIN_SECRETIONEER1.4964e-040.2564image
chr15:90272512-90275079:+KIRPGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER2.7986e-02-0.2398image
ENSG00000182768.8,NGRNKIRPGSVA_HALLMARK_SPERMATOGENESISEAG3.1418e-050.2792image
chr15:90276136-90277781:+LGGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER7.2503e-110.2806image
ENSG00000182768.8,NGRNLGGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG5.2082e-090.2523image
chr15:90272512-90275079:+LGGGSVA_HALLMARK_MITOTIC_SPINDLEEER3.4396e-09-0.2788image
chr15:90276136-90277781:+LIHCGSVA_HALLMARK_UV_RESPONSE_DNEER4.1986e-080.4431image
ENSG00000182768.8,NGRNLIHCGSVA_HALLMARK_UV_RESPONSE_DNEAG1.1483e-080.4534image
ENSG00000182768.8,NGRNLUADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG2.4919e-03-0.1665image
chr15:90272512-90275079:+LUADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.7006e-02-0.1993image
chr15:90276136-90277781:+LUADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.2456e-02-0.1396image
chr15:90276136-90277781:+LUSCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.1018e-040.1889image
ENSG00000182768.8,NGRNLUSCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG2.6259e-050.2048image
chr15:90272512-90275079:+LUSCGSVA_HALLMARK_UV_RESPONSE_UPEER2.2749e-050.2552image
ENSG00000182768.8,NGRNMESOGSVA_HALLMARK_MYC_TARGETS_V2EAG1.4889e-02-0.2766image
chr15:90272512-90275079:+MESOGSVA_HALLMARK_MYC_TARGETS_V1EER1.3713e-02-0.4072image
chr15:90276136-90277781:+MESOGSVA_HALLMARK_MYC_TARGETS_V2EER3.0859e-02-0.2462image
chr15:90276136-90277781:+OVGSVA_HALLMARK_APICAL_JUNCTIONEER7.5610e-070.3116image
ENSG00000182768.8,NGRNOVGSVA_HALLMARK_HEME_METABOLISMEAG1.8655e-070.3194image
chr15:90272512-90275079:+OVGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.0843e-030.2288image
ENSG00000182768.8,NGRNPAADGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.3880e-020.1938image
chr15:90272512-90275079:+PCPGGSVA_HALLMARK_MITOTIC_SPINDLEEER8.6805e-05-0.3325image
chr15:90276136-90277781:+PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.2176e-020.1897image
ENSG00000182768.8,NGRNPCPGGSVA_HALLMARK_BILE_ACID_METABOLISMEAG3.0635e-040.2705image
ENSG00000182768.8,NGRNPRADGSVA_HALLMARK_NOTCH_SIGNALINGEAG2.5785e-030.1450image
chr15:90272512-90275079:+PRADGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER5.1817e-030.1909image
chr15:90276136-90277781:+PRADGSVA_HALLMARK_NOTCH_SIGNALINGEER7.2460e-030.1301image
chr15:90276136-90277781:+READGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.5396e-030.3264image
ENSG00000182768.8,NGRNREADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.7321e-030.3309image
chr15:90276136-90277781:+SARCGSVA_HALLMARK_HEME_METABOLISMEER5.3786e-030.1850image
ENSG00000182768.8,NGRNSARCGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.6558e-030.1913image
ENSG00000182768.8,NGRNSKCMGSVA_HALLMARK_HEME_METABOLISMEAG3.4475e-110.3301image
chr15:90276136-90277781:+SKCMGSVA_HALLMARK_HEME_METABOLISMEER4.4722e-090.2959image
chr15:90272512-90275079:+SKCMGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.2450e-050.2899image
chr15:90272512-90275079:+STADGSVA_HALLMARK_FATTY_ACID_METABOLISMEER1.0325e-040.2230image
ENSG00000182768.8,NGRNSTADGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG5.1015e-050.2280image
chr15:90276136-90277781:+STADGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEER7.7921e-030.1641image
chr15:90276136-90277781:+TGCTGSVA_HALLMARK_MITOTIC_SPINDLEEER4.1615e-030.3874image
chr15:90272512-90275079:+TGCTGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.1000e-020.4887image
ENSG00000182768.8,NGRNTGCTGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.5542e-030.3803image
chr15:90276136-90277781:+THCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.6475e-060.2203image
ENSG00000182768.8,NGRNTHCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.1364e-070.2429image
chr15:90272512-90275079:+THCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER2.7432e-040.2314image
chr15:90272512-90275079:+THYMGSVA_HALLMARK_UV_RESPONSE_DNEER1.6180e-02-0.4218image
chr15:90276136-90277781:+THYMGSVA_HALLMARK_BILE_ACID_METABOLISMEER4.0882e-020.2306image
ENSG00000182768.8,NGRNTHYMGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.0544e-020.2862image
chr15:90272512-90275079:+UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.9621e-020.3888image
chr15:90276136-90277781:+UCECGSVA_HALLMARK_SPERMATOGENESISEER5.1551e-030.2468image
ENSG00000182768.8,NGRNUCECGSVA_HALLMARK_SPERMATOGENESISEAG4.2805e-030.2509image
chr15:90276136-90277781:+UVMGSVA_HALLMARK_PANCREAS_BETA_CELLSEER3.5465e-03-0.4558image
ENSG00000182768.8,NGRNUVMGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG4.9793e-03-0.4408image


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7. Enriched editing regions and drugs for NGRN


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr15:90276136-90277781:+ACCDMOGEER3.3366e-03-0.4034image
ENSG00000182768.8,NGRNACCDMOGEAG3.5960e-03-0.4004image
chr15:90276136-90277781:+BLCAAZD6482EER2.8618e-03-0.1829image
chr15:90272512-90275079:+BLCAAZD8055EER4.8907e-020.2209image
ENSG00000182768.8,NGRNBLCAAZD6482EAG2.9255e-03-0.1814image
ENSG00000182768.8,NGRNBRCAAZD6482EAG3.2346e-17-0.2647image
chr15:90272512-90275079:+BRCAMetforminEER4.5277e-03-0.1096image
chr15:90276136-90277781:+BRCAAZD6482EER3.4031e-15-0.2506image
ENSG00000182768.8,NGRNCESCBAY.61.3606EAG2.8557e-04-0.2485image
chr15:90276136-90277781:+CESCBAY.61.3606EER5.5231e-04-0.2375image
chr15:90272512-90275079:+CESCAZD6244EER3.1992e-02-0.2479image
chr15:90276136-90277781:+CHOLBleomycinEER1.9705e-02-0.4726image
ENSG00000182768.8,NGRNCHOLIPA.3EAG6.7793e-03-0.5175image
chr15:90272512-90275079:+COADGefitinibEER1.1025e-03-0.3672image
ENSG00000182768.8,NGRNCOADAICAREAG2.2889e-03-0.2223image
chr15:90276136-90277781:+COADKU.55933EER5.1879e-03-0.2081image
ENSG00000182768.8,NGRNESCABMS.509744EAG4.5411e-03-0.2247image
chr15:90272512-90275079:+ESCABMS.509744EER5.6753e-03-0.2205image
chr15:90276136-90277781:+ESCAAZD6482EER8.3818e-03-0.2131image
ENSG00000182768.8,NGRNGBMBI.D1870EAG9.9433e-080.4038image
chr15:90272512-90275079:+GBMGNF.2EER1.6590e-08-0.4638image
chr15:90276136-90277781:+GBMBI.D1870EER1.3800e-060.3687image
chr15:90272512-90275079:+HNSCCI.1040EER1.0906e-04-0.2860image
chr15:90276136-90277781:+HNSCBMS.708163EER5.4183e-04-0.1861image
ENSG00000182768.8,NGRNHNSCDMOGEAG1.5173e-04-0.1995image
ENSG00000182768.8,NGRNKICHJNJ.26854165EAG2.0410e-02-0.3148image
chr15:90276136-90277781:+KICHBMS.536924EER1.4009e-02-0.3388image
ENSG00000182768.8,NGRNKIRCDocetaxelEAG5.2607e-060.2530image
chr15:90272512-90275079:+KIRCCHIR.99021EER4.9762e-030.2024image
chr15:90276136-90277781:+KIRCEmbelinEER1.7125e-04-0.2132image
chr15:90272512-90275079:+KIRPCHIR.99021EER4.9080e-020.2154image
chr15:90276136-90277781:+KIRPAZD6244EER8.3221e-050.2657image
ENSG00000182768.8,NGRNKIRPAZD6244EAG1.9817e-050.2859image
ENSG00000182768.8,NGRNLAMLAMG.706EAG4.9516e-02-0.4052image
chr15:90276136-90277781:+LGGAKT.inhibitor.VIIIEER7.7404e-11-0.2802image
chr15:90272512-90275079:+LGGLenalidomideEER5.1115e-070.2383image
ENSG00000182768.8,NGRNLGGCEP.701EAG2.9784e-110.2858image
ENSG00000182768.8,NGRNLIHCImatinibEAG9.8416e-04-0.2718image
chr15:90276136-90277781:+LIHCGDC.0449EER2.4455e-030.2541image
chr15:90276136-90277781:+LUADAP.24534EER1.5161e-02-0.1357image
ENSG00000182768.8,NGRNLUADAP.24534EAG1.1799e-02-0.1389image
chr15:90272512-90275079:+LUADAZ628EER8.5819e-030.2214image
chr15:90272512-90275079:+LUSCBryostatin.1EER1.8130e-03-0.1893image
ENSG00000182768.8,NGRNLUSCCI.1040EAG3.2287e-04-0.1757image
chr15:90276136-90277781:+LUSCDasatinibEER2.9727e-04-0.1771image
ENSG00000182768.8,NGRNMESODMOGEAG8.7463e-05-0.4320image
chr15:90272512-90275079:+MESOLFM.A13EER3.3087e-03-0.4764image
chr15:90276136-90277781:+MESODMOGEER1.7654e-04-0.4148image
chr15:90272512-90275079:+OVATRAEER8.4390e-050.2737image
chr15:90276136-90277781:+OVDMOGEER3.8354e-05-0.2614image
ENSG00000182768.8,NGRNOVDMOGEAG6.3176e-06-0.2785image
chr15:90276136-90277781:+PAADCMKEER2.2270e-02-0.2112image
ENSG00000182768.8,NGRNPCPGDMOGEAG2.8226e-05-0.3117image
chr15:90272512-90275079:+PCPGBMS.536924EER7.5858e-03-0.2306image
chr15:90276136-90277781:+PCPGDMOGEER7.8866e-05-0.2947image
ENSG00000182768.8,NGRNPRADKIN001.135EAG1.0507e-02-0.1233image
chr15:90276136-90277781:+PRADKIN001.135EER1.4009e-02-0.1191image
chr15:90272512-90275079:+READA.770041EER3.1543e-030.4553image
chr15:90276136-90277781:+READBMS.509744EER2.9044e-02-0.2539image
ENSG00000182768.8,NGRNREADBMS.509744EAG4.8855e-02-0.2283image
chr15:90272512-90275079:+SARCImatinibEER1.6529e-02-0.2313image
chr15:90276136-90277781:+SARCCEP.701EER2.4622e-030.2009image
ENSG00000182768.8,NGRNSARCCEP.701EAG5.2308e-050.2640image
ENSG00000182768.8,NGRNSKCMBMS.754807EAG1.4561e-060.2432image
chr15:90276136-90277781:+SKCMBMS.754807EER1.9392e-060.2420image
chr15:90272512-90275079:+SKCMAG.014699EER8.9241e-050.2610image
ENSG00000182768.8,NGRNSTADFH535EAG1.1479e-050.2463image
chr15:90272512-90275079:+STADFH535EER1.0360e-060.2785image
chr15:90276136-90277781:+STADCI.1040EER4.1561e-03-0.1765image
chr15:90272512-90275079:+TGCTErlotinibEER5.2384e-03-0.5738image
chr15:90276136-90277781:+TGCTCGP.60474EER4.5098e-030.3842image
ENSG00000182768.8,NGRNTGCTCGP.60474EAG2.5658e-030.4023image
ENSG00000182768.8,NGRNTHCAAICAREAG2.9882e-07-0.2349image
chr15:90276136-90277781:+THCAAICAREER2.3590e-06-0.2171image
chr15:90272512-90275079:+THCAEmbelinEER5.2499e-060.2875image
chr15:90276136-90277781:+THYMCMKEER1.0838e-020.2852image
ENSG00000182768.8,NGRNTHYMCMKEAG6.3264e-030.3047image
chr15:90272512-90275079:+THYMBMS.754807EER2.4682e-030.5166image
chr15:90272512-90275079:+UCECCEP.701EER1.2525e-040.6818image
ENSG00000182768.8,NGRNUCECMethotrexateEAG1.6546e-02-0.2115image
chr15:90276136-90277781:+UCECMethotrexateEER1.6260e-02-0.2129image
ENSG00000182768.8,NGRNUCSFTI.277EAG3.0985e-02-0.3025image
chr15:90276136-90277781:+UCSA.443654EER2.5458e-02-0.3127image
chr15:90276136-90277781:+UVMGSK269962AEER7.1879e-030.4237image
ENSG00000182768.8,NGRNUVMGSK269962AEAG2.8451e-030.4652image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType