CAeditome Logo

Home

Download

Statistics

Landscape

Help

Contact
Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ZNF580 (ImmuneEditome ID:51157)

1. Gene summary of enriched editing regions for ZNF580

check button Gene summary
Gene informationGene symbol

ZNF580

Gene ID

51157

GeneSynonyms-
GeneCytomap

19q13.42

GeneTypeprotein-coding
GeneDescriptionzinc finger protein 580|LDL-induced EC protein
GeneModificationdate20230404
UniprotIDQ9UK33;K7ENY2;K7ERU0;K7EJ53
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr19:55637232-55639770:+ENST00000592881.1ENSG00000213015.7ZNF580intronicMSTB,AluSx,AluSc,AluJb,AluSz,MER20,MER3,G-rich,MIRchr19:55637232-55639770:+.alignment


Top

2. Tumor-specific enriched editing regions for ZNF580


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr19:55637232-55639770:+LUADEER3.0655e-02image
chr19:55637232-55639770:+LUSCEER3.6626e-02image
ENSG00000213015.7,ZNF580LUSCEAG7.6273e-03image
chr19:55637232-55639770:+STADEER1.6187e-02image
ENSG00000213015.7,ZNF580STADEAG2.4227e-02image
chr19:55637232-55639770:+THCAEER3.3382e-03image
ENSG00000213015.7,ZNF580THCAEAG9.9275e-03image


Top

check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000213015.7,ZNF580ESCAPathEAG1.0024e-022.3949e-020.1915image
chr19:55637232-55639770:+ESCAPathEER7.8179e-032.1186e-020.1954image


Top

check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr19:55637232-55639770:+KIRCEER1.5356e-029.3935e-033.2290e+01image
ENSG00000213015.7,ZNF580KIRCEAG2.7195e-031.8404e-026.2298e+00image
chr19:55637232-55639770:+LGGEER3.0424e-033.0785e-021.4833e-01image

Top

3. Enriched editing regions and immune related genes for ZNF580


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr19:55637232-55639770:+STADEERENSG00000131788,PIAS30.25325.1556e-043.1736e-150.4284imageNNPIAS3T_cells_CD4_memory_activatedGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr19:55637232-55639770:+STADEERENSG00000165458,INPPL10.20347.2397e-036.9745e-160.4376imageNNINPPL1Macrophages_M0GSVA_HALLMARK_MITOTIC_SPINDLE
chr19:55637232-55639770:+STADEERENSG00000144560,VGLL40.18841.5256e-022.5098e-160.4436imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr19:55637232-55639770:+STADEERENSG00000162729,IGSF80.17452.4947e-022.0017e-170.4580imageNNIGSF8Macrophages_M0GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr19:55637232-55639770:+STADEERENSG00000122642,FKBP90.16104.2397e-021.7950e-170.4586imageNNFKBP9Macrophages_M0GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING

More results



Top

4. Enriched editing regions and immune related splicing for ZNF580


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



Top

5. Enriched editing regions and immune infiltration for ZNF580


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr19:55637232-55639770:+ACCEERT_cells_CD4_memory_activated3.2078e-050.7663image
ENSG00000213015.7,ZNF580ACCEAGT_cells_CD4_memory_activated4.2816e-050.7351image
chr19:55637232-55639770:+BLCAEERB_cells_memory8.7528e-030.2477image
ENSG00000213015.7,ZNF580BLCAEAGB_cells_memory3.4672e-030.2740image
chr19:55637232-55639770:+BRCAEERMast_cells_resting4.0859e-02-0.0823image
chr19:55637232-55639770:+CESCEERDendritic_cells_activated4.9514e-02-0.2409image
ENSG00000213015.7,ZNF580CESCEAGDendritic_cells_activated4.6906e-02-0.2437image
chr19:55637232-55639770:+COADEEREosinophils1.4841e-02-0.3212image
ENSG00000213015.7,ZNF580COADEAGT_cells_CD82.0102e-020.3046image
chr19:55637232-55639770:+DLBCEERB_cells_naive6.1758e-030.4668image
ENSG00000213015.7,ZNF580DLBCEAGB_cells_naive9.1835e-030.4466image
chr19:55637232-55639770:+ESCAEERMacrophages_M23.3216e-020.1706image
ENSG00000213015.7,ZNF580ESCAEAGMacrophages_M23.5103e-020.1688image
chr19:55637232-55639770:+GBMEERT_cells_regulatory_(Tregs)1.9843e-020.2883image
chr19:55637232-55639770:+KIRCEERMast_cells_resting4.2394e-030.2050image
ENSG00000213015.7,ZNF580KIRCEAGMast_cells_resting6.1091e-030.1928image
chr19:55637232-55639770:+LAMLEERMonocytes1.5520e-02-0.2079image
ENSG00000213015.7,ZNF580LAMLEAGMonocytes3.8871e-02-0.1780image
chr19:55637232-55639770:+LUSCEERDendritic_cells_resting1.8185e-020.2093image
ENSG00000213015.7,ZNF580LUSCEAGDendritic_cells_resting3.6764e-020.1806image
chr19:55637232-55639770:+PAADEERNK_cells_resting2.9653e-020.2530image
ENSG00000213015.7,ZNF580PAADEAGNK_cells_resting1.2307e-020.2859image
ENSG00000213015.7,ZNF580READEAGNeutrophils4.1603e-020.4104image
chr19:55637232-55639770:+SARCEERT_cells_CD4_memory_activated3.3100e-020.3114image
ENSG00000213015.7,ZNF580SARCEAGT_cells_CD4_memory_activated3.5054e-020.3050image
ENSG00000213015.7,ZNF580THCAEAGT_cells_gamma_delta4.8788e-02-0.1097image
chr19:55637232-55639770:+THYMEERT_cells_CD4_naive3.2507e-020.2424image
ENSG00000213015.7,ZNF580THYMEAGT_cells_CD4_naive2.5184e-020.2518image
chr19:55637232-55639770:+UCECEERNeutrophils1.4454e-020.4494image
ENSG00000213015.7,ZNF580UCECEAGNeutrophils1.5412e-020.4456image


Top

6. Enriched editing regions and immune gene sets for ZNF580


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


Top

check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


Top

check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr19:55637232-55639770:+BLCAGSVA_HALLMARK_ANDROGEN_RESPONSEEER1.5359e-040.3517image
ENSG00000213015.7,ZNF580BLCAGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.7431e-040.3475image
chr19:55637232-55639770:+BRCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.8541e-060.1904image
ENSG00000213015.7,ZNF580BRCAGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.0458e-060.1919image
chr19:55637232-55639770:+CESCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER6.0658e-030.3319image
ENSG00000213015.7,ZNF580CESCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG2.6295e-030.3618image
ENSG00000213015.7,ZNF580ESCAGSVA_HALLMARK_SPERMATOGENESISEAG1.1432e-020.2020image
chr19:55637232-55639770:+ESCAGSVA_HALLMARK_MYOGENESISEER1.2038e-020.2006image
chr19:55637232-55639770:+GBMGSVA_HALLMARK_UV_RESPONSE_DNEER4.6303e-020.2481image
ENSG00000213015.7,ZNF580GBMGSVA_HALLMARK_UV_RESPONSE_DNEAG2.8336e-020.2721image
chr19:55637232-55639770:+KICHGSVA_HALLMARK_SPERMATOGENESISEER5.5879e-030.4302image
ENSG00000213015.7,ZNF580KICHGSVA_HALLMARK_SPERMATOGENESISEAG6.8562e-030.4110image
chr19:55637232-55639770:+KIRCGSVA_HALLMARK_DNA_REPAIREER8.6378e-040.2379image
ENSG00000213015.7,ZNF580KIRCGSVA_HALLMARK_DNA_REPAIREAG4.2166e-030.2010image
ENSG00000213015.7,ZNF580KIRPGSVA_HALLMARK_PEROXISOMEEAG1.3709e-030.3498image
chr19:55637232-55639770:+KIRPGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER2.0660e-040.4108image
chr19:55637232-55639770:+LAMLGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.4488e-02-0.2100image
ENSG00000213015.7,ZNF580LAMLGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.4470e-02-0.2101image
chr19:55637232-55639770:+LGGGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.8980e-020.1719image
chr19:55637232-55639770:+LUADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER7.4036e-030.1843image
ENSG00000213015.7,ZNF580LUADGSVA_HALLMARK_PROTEIN_SECRETIONEAG7.5534e-040.2255image
chr19:55637232-55639770:+LUSCGSVA_HALLMARK_PROTEIN_SECRETIONEER5.0894e-030.2472image
ENSG00000213015.7,ZNF580LUSCGSVA_HALLMARK_PROTEIN_SECRETIONEAG7.2192e-030.2311image
chr19:55637232-55639770:+OVGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER9.2775e-050.2658image
ENSG00000213015.7,ZNF580OVGSVA_HALLMARK_HEME_METABOLISMEAG1.0231e-040.2630image
ENSG00000213015.7,ZNF580PAADGSVA_HALLMARK_COAGULATIONEAG1.3009e-020.2837image
chr19:55637232-55639770:+PAADGSVA_HALLMARK_UV_RESPONSE_UPEER1.9484e-020.2711image
chr19:55637232-55639770:+PCPGGSVA_HALLMARK_GLYCOLYSISEER5.3415e-030.2627image
chr19:55637232-55639770:+PRADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER2.5755e-030.1604image
ENSG00000213015.7,ZNF580PRADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG3.7967e-030.1528image
ENSG00000213015.7,ZNF580READGSVA_HALLMARK_MITOTIC_SPINDLEEAG6.8514e-030.5265image
chr19:55637232-55639770:+READGSVA_HALLMARK_MITOTIC_SPINDLEEER7.4472e-030.5321image
chr19:55637232-55639770:+SARCGSVA_HALLMARK_E2F_TARGETSEER1.2308e-030.4573image
ENSG00000213015.7,ZNF580SARCGSVA_HALLMARK_G2M_CHECKPOINTEAG5.2633e-040.4818image
chr19:55637232-55639770:+SKCMGSVA_HALLMARK_BILE_ACID_METABOLISMEER3.2765e-040.3471image
ENSG00000213015.7,ZNF580SKCMGSVA_HALLMARK_BILE_ACID_METABOLISMEAG3.7580e-040.3407image
chr19:55637232-55639770:+STADGSVA_HALLMARK_MITOTIC_SPINDLEEER1.4105e-050.2443image
ENSG00000213015.7,ZNF580STADGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.5898e-050.2290image
chr19:55637232-55639770:+THCAGSVA_HALLMARK_ANDROGEN_RESPONSEEER2.6913e-040.2046image
ENSG00000213015.7,ZNF580THCAGSVA_HALLMARK_ANDROGEN_RESPONSEEAG5.0408e-050.2236image
chr19:55637232-55639770:+THYMGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER3.8767e-040.3919image
ENSG00000213015.7,ZNF580THYMGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG1.0101e-040.4234image
chr19:55637232-55639770:+UCECGSVA_HALLMARK_PROTEIN_SECRETIONEER4.3123e-040.6109image
ENSG00000213015.7,ZNF580UCECGSVA_HALLMARK_PROTEIN_SECRETIONEAG4.6866e-040.6079image


Top

7. Enriched editing regions and drugs for ZNF580


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000213015.7,ZNF580ACCBMS.754807EAG6.5213e-030.5394image
chr19:55637232-55639770:+ACCBMS.754807EER1.3832e-020.5166image
chr19:55637232-55639770:+BLCABryostatin.1EER4.3588e-020.1919image
ENSG00000213015.7,ZNF580BLCABMS.754807EAG3.4059e-020.2005image
chr19:55637232-55639770:+BRCAAZD.0530EER1.6051e-03-0.1269image
ENSG00000213015.7,ZNF580BRCAAZD.0530EAG1.1720e-03-0.1284image
chr19:55637232-55639770:+CESCBIBW2992EER8.6803e-030.3182image
ENSG00000213015.7,ZNF580CESCA.443654EAG9.0926e-030.3164image
ENSG00000213015.7,ZNF580COADEHT.1864EAG6.8894e-03-0.3511image
chr19:55637232-55639770:+COADEHT.1864EER7.7761e-03-0.3491image
ENSG00000213015.7,ZNF580DLBCGDC.0449EAG3.0006e-020.3782image
chr19:55637232-55639770:+ESCAGSK269962AEER1.6703e-02-0.1914image
ENSG00000213015.7,ZNF580ESCAGSK269962AEAG2.2260e-02-0.1829image
chr19:55637232-55639770:+GBMElesclomolEER9.8712e-030.3179image
ENSG00000213015.7,ZNF580GBMElesclomolEAG1.2745e-020.3074image
chr19:55637232-55639770:+KICHDasatinibEER5.7133e-030.4345image
ENSG00000213015.7,ZNF580KICHAG.014699EAG1.8400e-030.4666image
chr19:55637232-55639770:+KIRCGSK.650394EER3.9516e-02-0.1483image
ENSG00000213015.7,ZNF580KIRCGSK.650394EAG2.3084e-02-0.1602image
chr19:55637232-55639770:+KIRPMetforminEER2.3516e-02-0.2580image
ENSG00000213015.7,ZNF580LAMLGW.441756EAG7.0804e-05-0.3352image
chr19:55637232-55639770:+LAMLGW.441756EER7.6247e-05-0.3338image
ENSG00000213015.7,ZNF580LGGJNK.Inhibitor.VIIIEAG8.6760e-03-0.1856image
chr19:55637232-55639770:+LGGJNK.Inhibitor.VIIIEER1.9864e-02-0.1707image
ENSG00000213015.7,ZNF580LUSCFTI.277EAG6.5355e-03-0.2339image
chr19:55637232-55639770:+LUSCBX.795EER3.4757e-020.1875image
chr19:55637232-55639770:+OVAS601245EER2.5772e-03-0.2065image
ENSG00000213015.7,ZNF580OVAS601245EAG2.7022e-03-0.2046image
chr19:55637232-55639770:+PAADBicalutamideEER2.6179e-02-0.2639image
ENSG00000213015.7,ZNF580PAADBicalutamideEAG1.8578e-02-0.2749image
ENSG00000213015.7,ZNF580PCPGLapatinibEAG2.1971e-020.2135image
chr19:55637232-55639770:+PRADFH535EER3.5738e-03-0.1551image
ENSG00000213015.7,ZNF580PRADFH535EAG3.3820e-03-0.1547image
ENSG00000213015.7,ZNF580READDocetaxelEAG4.8169e-02-0.3990image
chr19:55637232-55639770:+SARCBI.D1870EER2.6051e-02-0.3245image
ENSG00000213015.7,ZNF580SARCBI.D1870EAG2.2629e-02-0.3285image
chr19:55637232-55639770:+SKCMEtoposideEER2.4446e-020.2216image
ENSG00000213015.7,ZNF580SKCMCEP.701EAG1.7387e-020.2317image
ENSG00000213015.7,ZNF580STADAS601245EAG6.0368e-03-0.1554image
chr19:55637232-55639770:+STADAS601245EER6.0257e-03-0.1559image
ENSG00000213015.7,ZNF580THCAAMG.706EAG2.0894e-030.1706image
chr19:55637232-55639770:+THCAAMG.706EER1.1134e-020.1433image
chr19:55637232-55639770:+THYMDasatinibEER1.9509e-020.2657image
ENSG00000213015.7,ZNF580THYMJNK.Inhibitor.VIIIEAG2.8571e-02-0.2464image
chr19:55637232-55639770:+UCECGDC.0449EER1.8355e-040.6402image
ENSG00000213015.7,ZNF580UCECGDC.0449EAG1.5894e-040.6449image


Top

check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType