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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: COQ4 (ImmuneEditome ID:51117)

1. Gene summary of enriched editing regions for COQ4

check button Gene summary
Gene informationGene symbol

COQ4

Gene ID

51117

GeneSynonymsCGI-92|COQ10D7
GeneCytomap

9q34.11

GeneTypeprotein-coding
GeneDescriptionubiquinone biosynthesis protein COQ4 homolog, mitochondrial|coenzyme Q biosynthesis protein 4 homolog|coenzyme Q4 homolog
GeneModificationdate20230517
UniprotIDQ9Y3A0;V9GY32;Q5T4B9;V9GZ09
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr9:128323705-128324676:+ENST00000300452.6ENSG00000167113.9COQ4intronicAluSz6,AluJb,AluJr4,MIRbchr9:128323705-128324676:+.alignment
chr9:128323705-128324676:+ENST00000372875.3ENSG00000167113.9COQ4intronicAluSz6,AluJb,AluJr4,MIRbchr9:128323705-128324676:+.alignment
chr9:128326520-128327830:+ENST00000300452.6ENSG00000167113.9COQ4intronicL2a,AluSz,AluSx,AluJb,AluYchr9:128326520-128327830:+.alignment
chr9:128329391-128332039:+ENST00000461102.1ENSG00000167113.9COQ4ncRNA_exonicAluSx1,AluY,MER33,MIRb,L2c,AluJo,AluSx,AluSx3,AluSzchr9:128329391-128332039:+.alignment


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2. Tumor-specific enriched editing regions for COQ4


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
ENSG00000167113.9,COQ4THCAEAG1.6385e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000167113.9,COQ4BLCAPathEAG1.0752e-021.5910e-030.1804image
chr9:128329391-128332039:+BLCAPathEER1.1708e-021.9442e-030.1770image
chr9:128329391-128332039:+CESCCliEER5.8896e-049.9028e-04-0.2071image
ENSG00000167113.9,COQ4CESCCliEAG5.4820e-042.9114e-03-0.1875image
chr9:128326520-128327830:+KIRCPathEER3.4017e-027.3284e-030.1768image
ENSG00000167113.9,COQ4KIRPPathEAG3.9564e-025.9286e-030.1925image
ENSG00000167113.9,COQ4UVMPathEAG2.3513e-026.0575e-030.4372image
chr9:128329391-128332039:+UVMPathEER1.8033e-024.4047e-030.4518image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr9:128329391-128332039:+BRCAEER2.8379e-029.6725e-031.8779e+01image
chr9:128329391-128332039:+OVEER1.2993e-024.7166e-024.2197e+00image
chr9:128329391-128332039:+UCSEER1.3230e-022.7559e-033.4784e+03image
ENSG00000167113.9,COQ4UCSEAG1.3230e-022.7819e-033.4479e+03image

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3. Enriched editing regions and immune related genes for COQ4


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr9:128326520-128327830:+ESCAEERENSG00000273137,RP3-402G11.28-0.40561.5958e-031.5088e-06-0.4031imageNEIF4A3;FBLNAT_cells_CD4_memory_restingGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr9:128329391-128332039:+ESCAEERENSG00000279382,RP11-449J21.3-0.51783.6650e-071.6195e-09-0.4542imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr9:128329391-128332039:+ESCAEERENSG00000212695,RP11-134K1.20.35622.6131e-036.4027e-080.4116imageNNNAT_cells_CD8GSVA_HALLMARK_MITOTIC_SPINDLE
chr9:128329391-128332039:+OVEERENSG00000187840,EIF4EBP10.20421.9260e-021.5612e-120.4171imageNCSTF2T;DGCR8;IGF2BP2;TARDBPNAT_cells_CD4_memory_restingGSVA_HALLMARK_DNA_REPAIR
chr9:128329391-128332039:+PCPGEERENSG00000223959,AFG3L1P-0.41088.2762e-058.5472e-08-0.4190imageNNNAMacrophages_M0GSVA_HALLMARK_GLYCOLYSIS

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4. Enriched editing regions and immune related splicing for COQ4


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000167113.9,COQ4
ESCAEAGIRENSG00000158062.16chr126284361:26284482:26285463:26285541-0.43564.1680e-044.1997e-08-0.4168imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YWHAG;ZNF184NAB_cells_naiveGSVA_HALLMARK_GLYCOLYSIS
ENSG00000167113.9,COQ4
ESCAEAGIRENSG00000073169.9chr2250200978:50206520:50208535:50208716-0.45841.1314e-042.8631e-08-0.4214imageNACIN1;ADAR;AIFM1;ALYREF;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FUS;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000167113.9,COQ4
ESCAEAGIRENSG00000196730.8chr987681403:87681626:87686550:87686739-0.40951.1314e-045.5208e-07-0.4255imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP7;LIN28;LIN28B;MOV10;MSI2;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM5;RTCB;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1DAPK1Mast_cells_activatedGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000167113.9,COQ4
ESCAEAGIRENSG00000111725.6chr12119671494:119671668:119672300:119672427-0.37131.5552e-034.8371e-08-0.4502imageNADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DKC1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;SAFB2;SBDS;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184PRKAB1T_cells_CD4_memory_restingGSVA_HALLMARK_MTORC1_SIGNALING
ENSG00000167113.9,COQ4
ESCAEAGIRENSG00000172663.4chr1167464802:67465267:67467164:67467388-0.29712.6493e-021.8009e-06-0.4003imageNAIFM1;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;DKC1;EIF4A3;FAM120A;FBL;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;IGF2BP2;IGF2BP3;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;SF3A3;SF3B4;SLTM;SND1;SRSF1;SRSF7;SRSF9;TAF15;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;ZNF184NAMacrophages_M1GSVA_HALLMARK_MYC_TARGETS_V1
ENSG00000167113.9,COQ4
ESCAEAGIRENSG00000108651.5chr1731878249:31878327:31880572:31880754-0.32391.3842e-024.1806e-08-0.4375imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM5;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YWHAG;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr9:128326520-128327830:+
ESCAEERIRENSG00000130703.11chr2062284045:62284169:62285535:62285686-0.32321.6171e-021.5828e-05-0.4077imageNEIF4A3;ELAVL1;FBL;NOP56;U2AF2NAB_cells_naiveGSVA_HALLMARK_MTORC1_SIGNALING
ENSG00000167113.9,COQ4
ESCAEAGIRENSG00000168591.11chr1744187271:44188009:44188934:44189079-0.46803.6474e-051.6484e-08-0.4343imageNADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LIN28;LIN28B;LSM11;MOV10;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAMacrophages_M2GSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSE
ENSG00000167113.9,COQ4
ESCAEAGIRENSG00000163714.13chr3143022852:143023064:143027148:143027253-0.42922.2689e-041.8399e-09-0.4606imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM5;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_HYPOXIA
ENSG00000167113.9,COQ4
ESCAEAGIRENSG00000115875.14chr238748578:38748653:38748897:38749015-0.39033.2842e-035.9402e-08-0.4125imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM5;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YWHAG;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA

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5. Enriched editing regions and immune infiltration for COQ4


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr9:128326520-128327830:+BLCAEERNeutrophils1.8448e-020.3009image
chr9:128329391-128332039:+BLCAEERMacrophages_M14.4502e-020.1150image
ENSG00000167113.9,COQ4BLCAEAGMacrophages_M14.8878e-020.1127image
chr9:128326520-128327830:+BRCAEERB_cells_memory9.1273e-030.1119image
chr9:128329391-128332039:+BRCAEERT_cells_regulatory_(Tregs)3.0028e-03-0.0973image
ENSG00000167113.9,COQ4BRCAEAGDendritic_cells_activated3.5563e-030.0953image
chr9:128326520-128327830:+CESCEERT_cells_CD4_memory_activated1.4900e-02-0.2942image
chr9:128329391-128332039:+CESCEERNK_cells_resting6.9403e-030.1693image
ENSG00000167113.9,COQ4CESCEAGNK_cells_resting7.3831e-030.1681image
chr9:128329391-128332039:+CHOLEERMacrophages_M21.4900e-020.4403image
ENSG00000167113.9,COQ4CHOLEAGMacrophages_M21.0834e-020.4585image
chr9:128326520-128327830:+COADEERDendritic_cells_activated7.9519e-050.4798image
chr9:128329391-128332039:+ESCAEERMacrophages_M23.3695e-020.1680image
ENSG00000167113.9,COQ4ESCAEAGMacrophages_M29.4865e-030.2045image
chr9:128326520-128327830:+GBMEERT_cells_CD4_memory_activated1.8195e-020.2668image
chr9:128329391-128332039:+GBMEERNK_cells_resting3.2193e-02-0.1756image
chr9:128326520-128327830:+HNSCEERMast_cells_activated3.6333e-030.4604image
chr9:128329391-128332039:+KICHEERMacrophages_M11.5468e-030.4733image
ENSG00000167113.9,COQ4KICHEAGMacrophages_M12.2163e-030.4593image
chr9:128329391-128332039:+KIRCEERDendritic_cells_activated2.4305e-020.1410image
ENSG00000167113.9,COQ4KIRCEAGDendritic_cells_activated2.8383e-020.1370image
chr9:128329391-128332039:+KIRPEERT_cells_CD4_memory_activated3.8910e-030.1917image
ENSG00000167113.9,COQ4KIRPEAGT_cells_CD4_memory_activated3.0253e-030.1960image
chr9:128326520-128327830:+LAMLEERDendritic_cells_resting3.8719e-030.2745image
chr9:128329391-128332039:+LAMLEERT_cells_CD84.1682e-020.1712image
ENSG00000167113.9,COQ4LAMLEAGNeutrophils3.4543e-020.1763image
chr9:128326520-128327830:+LGGEERMacrophages_M22.9825e-020.1325image
chr9:128329391-128332039:+LGGEERMacrophages_M12.5791e-020.1021image
ENSG00000167113.9,COQ4LGGEAGNK_cells_activated2.9073e-02-0.0997image
chr9:128326520-128327830:+LUADEEREosinophils1.7323e-050.3486image
chr9:128329391-128332039:+LUADEERDendritic_cells_activated1.0441e-030.1721image
ENSG00000167113.9,COQ4LUADEAGT_cells_regulatory_(Tregs)6.1174e-04-0.1790image
chr9:128329391-128332039:+LUSCEERT_cells_gamma_delta1.2892e-030.1719image
ENSG00000167113.9,COQ4LUSCEAGT_cells_gamma_delta7.5385e-040.1793image
chr9:128329391-128332039:+MESOEERT_cells_CD4_memory_resting9.0184e-03-0.3191image
ENSG00000167113.9,COQ4MESOEAGT_cells_CD4_memory_resting9.0810e-03-0.3188image
chr9:128326520-128327830:+OVEERT_cells_gamma_delta2.2358e-020.1778image
chr9:128329391-128332039:+OVEERB_cells_memory1.9690e-030.1896image
ENSG00000167113.9,COQ4OVEAGB_cells_memory3.3900e-040.2181image
chr9:128326520-128327830:+PAADEERT_cells_CD84.7574e-02-0.3152image
chr9:128329391-128332039:+PCPGEERT_cells_follicular_helper1.3062e-02-0.2016image
ENSG00000167113.9,COQ4PCPGEAGT_cells_follicular_helper1.7925e-02-0.1924image
chr9:128326520-128327830:+PRADEERT_cells_regulatory_(Tregs)2.7587e-020.1904image
chr9:128329391-128332039:+READEERDendritic_cells_resting4.6065e-020.2523image
chr9:128326520-128327830:+SARCEEREosinophils2.5372e-050.7723image
chr9:128329391-128332039:+SARCEERMacrophages_M24.4065e-020.1669image
ENSG00000167113.9,COQ4SARCEAGMacrophages_M24.5392e-020.1653image
chr9:128326520-128327830:+SKCMEERT_cells_CD4_memory_resting6.2104e-030.2485image
chr9:128329391-128332039:+SKCMEERNK_cells_resting2.0774e-02-0.1296image
ENSG00000167113.9,COQ4SKCMEAGT_cells_follicular_helper2.2226e-02-0.1278image
chr9:128326520-128327830:+STADEERPlasma_cells3.7063e-030.2023image
chr9:128329391-128332039:+STADEERT_cells_CD4_memory_resting1.2046e-03-0.1783image
ENSG00000167113.9,COQ4STADEAGT_cells_CD4_memory_resting3.2706e-03-0.1619image
chr9:128326520-128327830:+TGCTEERMacrophages_M23.2933e-030.5190image
chr9:128329391-128332039:+THCAEERDendritic_cells_resting1.0773e-020.1175image
ENSG00000167113.9,COQ4THCAEAGDendritic_cells_resting7.3035e-030.1235image
chr9:128329391-128332039:+THYMEERMacrophages_M03.5707e-030.2806image
ENSG00000167113.9,COQ4THYMEAGMacrophages_M05.9108e-030.2657image
ENSG00000167113.9,COQ4UVMEAGDendritic_cells_resting4.7424e-020.3195image


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6. Enriched editing regions and immune gene sets for COQ4


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr9:128329391-128332039:+ACCGSVA_HALLMARK_HEME_METABOLISMEER2.9904e-030.3800image
ENSG00000167113.9,COQ4ACCGSVA_HALLMARK_HEME_METABOLISMEAG2.5219e-030.3862image
chr9:128329391-128332039:+BLCAGSVA_HALLMARK_HYPOXIAEER2.5480e-050.2382image
ENSG00000167113.9,COQ4BLCAGSVA_HALLMARK_HYPOXIAEAG1.3385e-050.2461image
chr9:128326520-128327830:+BLCAGSVA_HALLMARK_ANDROGEN_RESPONSEEER2.4323e-020.2882image
chr9:128329391-128332039:+BRCAGSVA_HALLMARK_ANDROGEN_RESPONSEEER2.5077e-100.2056image
ENSG00000167113.9,COQ4BRCAGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.5346e-080.1839image
chr9:128326520-128327830:+BRCAGSVA_HALLMARK_HEME_METABOLISMEER1.3068e-02-0.1066image
chr9:128329391-128332039:+CESCGSVA_HALLMARK_ANDROGEN_RESPONSEEER3.5367e-070.3136image
chr9:128326520-128327830:+CESCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER1.0292e-030.3894image
ENSG00000167113.9,COQ4CESCGSVA_HALLMARK_ANDROGEN_RESPONSEEAG6.5960e-070.3066image
chr9:128329391-128332039:+CHOLGSVA_HALLMARK_PANCREAS_BETA_CELLSEER2.9773e-040.6151image
ENSG00000167113.9,COQ4CHOLGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.9481e-040.6154image
chr9:128326520-128327830:+COADGSVA_HALLMARK_PEROXISOMEEER8.1391e-03-0.3332image
ENSG00000167113.9,COQ4COADGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.5655e-020.1729image
chr9:128329391-128332039:+COADGSVA_HALLMARK_PROTEIN_SECRETIONEER9.2457e-030.1860image
ENSG00000167113.9,COQ4DLBCGSVA_HALLMARK_DNA_REPAIREAG2.2673e-02-0.4369image
ENSG00000167113.9,COQ4ESCAGSVA_HALLMARK_HYPOXIAEAG1.7536e-030.2455image
chr9:128326520-128327830:+ESCAGSVA_HALLMARK_COMPLEMENTEER6.3853e-030.2354image
chr9:128329391-128332039:+ESCAGSVA_HALLMARK_HYPOXIAEER2.5593e-030.2369image
chr9:128329391-128332039:+GBMGSVA_HALLMARK_UV_RESPONSE_UPEER1.3464e-040.3077image
ENSG00000167113.9,COQ4GBMGSVA_HALLMARK_APOPTOSISEAG4.2369e-040.2842image
chr9:128326520-128327830:+HNSCGSVA_HALLMARK_HYPOXIAEER2.1047e-030.4835image
ENSG00000167113.9,COQ4KICHGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG3.5957e-020.3246image
chr9:128326520-128327830:+KIRCGSVA_HALLMARK_SPERMATOGENESISEER2.6453e-030.2406image
ENSG00000167113.9,COQ4KIRCGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG1.0443e-080.3482image
chr9:128329391-128332039:+KIRCGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER7.2035e-070.3044image
ENSG00000167113.9,COQ4KIRPGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.5016e-060.3066image
chr9:128329391-128332039:+KIRPGSVA_HALLMARK_PANCREAS_BETA_CELLSEER3.9353e-060.3021image
chr9:128326520-128327830:+KIRPGSVA_HALLMARK_PANCREAS_BETA_CELLSEER4.2063e-020.1851image
ENSG00000167113.9,COQ4LAMLGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG1.7329e-03-0.2588image
chr9:128326520-128327830:+LAMLGSVA_HALLMARK_MYC_TARGETS_V2EER3.0347e-03-0.2814image
chr9:128329391-128332039:+LAMLGSVA_HALLMARK_FATTY_ACID_METABOLISMEER7.7922e-03-0.2225image
ENSG00000167113.9,COQ4LGGGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG5.8270e-070.2259image
chr9:128329391-128332039:+LGGGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER1.3330e-070.2386image
ENSG00000167113.9,COQ4LIHCGSVA_HALLMARK_COAGULATIONEAG7.6428e-030.2519image
chr9:128329391-128332039:+LIHCGSVA_HALLMARK_COAGULATIONEER6.7802e-030.2556image
ENSG00000167113.9,COQ4LUADGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.7192e-040.1960image
chr9:128329391-128332039:+LUADGSVA_HALLMARK_PROTEIN_SECRETIONEER6.3254e-050.2092image
ENSG00000167113.9,COQ4LUSCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG6.9077e-040.1805image
chr9:128329391-128332039:+LUSCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER2.6493e-030.1606image
chr9:128326520-128327830:+LUSCGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.2401e-020.2335image
chr9:128326520-128327830:+OVGSVA_HALLMARK_ANDROGEN_RESPONSEEER1.4661e-03-0.2457image
chr9:128329391-128332039:+OVGSVA_HALLMARK_MYC_TARGETS_V1EER5.1727e-040.2122image
ENSG00000167113.9,COQ4OVGSVA_HALLMARK_MITOTIC_SPINDLEEAG5.4157e-04-0.2107image
chr9:128329391-128332039:+PAADGSVA_HALLMARK_HYPOXIAEER1.0689e-030.2718image
chr9:128326520-128327830:+PAADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER2.5971e-02-0.3519image
ENSG00000167113.9,COQ4PAADGSVA_HALLMARK_HYPOXIAEAG1.6066e-030.2624image
chr9:128329391-128332039:+PCPGGSVA_HALLMARK_ANDROGEN_RESPONSEEER3.8074e-060.3660image
chr9:128326520-128327830:+PCPGGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER2.7898e-020.3050image
ENSG00000167113.9,COQ4PCPGGSVA_HALLMARK_ANDROGEN_RESPONSEEAG4.0717e-060.3650image
ENSG00000167113.9,COQ4PRADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG3.5124e-040.1763image
chr9:128326520-128327830:+PRADGSVA_HALLMARK_COAGULATIONEER1.2414e-020.2155image
chr9:128329391-128332039:+PRADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.2314e-030.1598image
chr9:128329391-128332039:+READGSVA_HALLMARK_UV_RESPONSE_UPEER2.4405e-02-0.2834image
ENSG00000167113.9,COQ4READGSVA_HALLMARK_UV_RESPONSE_UPEAG3.0113e-02-0.2735image
chr9:128326520-128327830:+SARCGSVA_HALLMARK_MTORC1_SIGNALINGEER9.2749e-030.5413image
chr9:128329391-128332039:+SARCGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER1.3929e-040.3101image
ENSG00000167113.9,COQ4SARCGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG6.8595e-050.3223image
chr9:128329391-128332039:+SKCMGSVA_HALLMARK_ANDROGEN_RESPONSEEER2.3157e-050.2349image
ENSG00000167113.9,COQ4SKCMGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.3278e-040.2120image
chr9:128326520-128327830:+SKCMGSVA_HALLMARK_HYPOXIAEER4.4447e-02-0.1838image
chr9:128329391-128332039:+STADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER4.5084e-050.2236image
chr9:128326520-128327830:+STADGSVA_HALLMARK_SPERMATOGENESISEER1.0774e-030.2273image
ENSG00000167113.9,COQ4STADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.2035e-060.2579image
chr9:128326520-128327830:+TGCTGSVA_HALLMARK_ANDROGEN_RESPONSEEER1.1349e-020.4559image
ENSG00000167113.9,COQ4TGCTGSVA_HALLMARK_MITOTIC_SPINDLEEAG6.5001e-030.2323image
chr9:128329391-128332039:+TGCTGSVA_HALLMARK_MITOTIC_SPINDLEEER9.5386e-030.2216image
chr9:128326520-128327830:+THCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER4.7382e-040.2057image
chr9:128329391-128332039:+THCAGSVA_HALLMARK_KRAS_SIGNALING_UPEER2.9863e-080.2522image
ENSG00000167113.9,COQ4THCAGSVA_HALLMARK_HYPOXIAEAG2.1556e-080.2544image
chr9:128326520-128327830:+THYMGSVA_HALLMARK_APICAL_SURFACEEER4.8219e-03-0.5172image
chr9:128329391-128332039:+THYMGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER4.5262e-020.1949image
chr9:128329391-128332039:+UCECGSVA_HALLMARK_UV_RESPONSE_UPEER7.8763e-040.2920image
ENSG00000167113.9,COQ4UCECGSVA_HALLMARK_UV_RESPONSE_UPEAG7.8651e-040.2920image
ENSG00000167113.9,COQ4UCSGSVA_HALLMARK_HEME_METABOLISMEAG2.2454e-020.3848image
chr9:128329391-128332039:+UCSGSVA_HALLMARK_HEME_METABOLISMEER2.2147e-020.3856image


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7. Enriched editing regions and drugs for COQ4


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000167113.9,COQ4ACCAICAREAG4.6634e-03-0.3635image
chr9:128329391-128332039:+ACCAICAREER5.4628e-03-0.3573image
chr9:128329391-128332039:+BLCACisplatinEER4.3116e-04-0.2000image
ENSG00000167113.9,COQ4BLCACisplatinEAG3.6098e-04-0.2026image
chr9:128329391-128332039:+BRCAEHT.1864EER3.9793e-040.1160image
ENSG00000167113.9,COQ4BRCAEHT.1864EAG8.6206e-050.1282image
chr9:128326520-128327830:+BRCAAMG.706EER3.2137e-03-0.1263image
chr9:128329391-128332039:+CESCEHT.1864EER1.4475e-020.1536image
chr9:128326520-128327830:+CESCBMS.536924EER4.9310e-050.4715image
ENSG00000167113.9,COQ4CESCBicalutamideEAG1.7989e-02-0.1486image
chr9:128329391-128332039:+CHOLMetforminEER9.3888e-030.4663image
ENSG00000167113.9,COQ4CHOLMetforminEAG1.3316e-020.4468image
chr9:128326520-128327830:+COADAG.014699EER8.7228e-03-0.3304image
ENSG00000167113.9,COQ4COADBI.D1870EAG1.6114e-020.1721image
chr9:128329391-128332039:+COADBI.D1870EER1.4874e-020.1742image
ENSG00000167113.9,COQ4DLBCCCT007093EAG5.5375e-03-0.5190image
ENSG00000167113.9,COQ4ESCAAZD8055EAG8.0108e-06-0.3448image
chr9:128326520-128327830:+ESCABMS.509744EER5.0623e-03-0.2417image
chr9:128329391-128332039:+ESCAAZD8055EER3.1288e-05-0.3229image
chr9:128329391-128332039:+GBMDasatinibEER3.1646e-04-0.2920image
ENSG00000167113.9,COQ4GBMDasatinibEAG5.3331e-04-0.2804image
chr9:128326520-128327830:+GBMAICAREER4.9724e-02-0.2230image
ENSG00000167113.9,COQ4HNSCCCT007093EAG3.8281e-02-0.1438image
chr9:128329391-128332039:+HNSCCCT007093EER2.9314e-02-0.1519image
chr9:128326520-128327830:+HNSCBexaroteneEER1.8779e-02-0.3795image
chr9:128329391-128332039:+KICHBryostatin.1EER2.7677e-020.3398image
ENSG00000167113.9,COQ4KICHDasatinibEAG3.6507e-020.3237image
chr9:128326520-128327830:+KIRCAUY922EER2.7891e-030.2394image
chr9:128329391-128332039:+KIRCMG.132EER1.8269e-02-0.1480image
ENSG00000167113.9,COQ4KIRCMG.132EAG1.8292e-03-0.1943image
chr9:128329391-128332039:+KIRPLFM.A13EER1.0078e-030.2178image
ENSG00000167113.9,COQ4KIRPCCT007093EAG2.9357e-040.2382image
chr9:128326520-128327830:+KIRPAxitinibEER4.6662e-03-0.2556image
chr9:128326520-128327830:+LAMLBI.2536EER2.9907e-020.2081image
ENSG00000167113.9,COQ4LGGGSK.650394EAG1.0943e-060.2205image
chr9:128329391-128332039:+LGGGSK.650394EER1.6624e-070.2368image
ENSG00000167113.9,COQ4LIHCAICAREAG7.7002e-03-0.2517image
chr9:128329391-128332039:+LIHCAICAREER5.5325e-03-0.2617image
ENSG00000167113.9,COQ4LUADBMS.536924EAG6.7719e-040.1781image
chr9:128329391-128332039:+LUADMethotrexateEER1.4888e-030.1671image
ENSG00000167113.9,COQ4LUSCJW.7.52.1EAG4.3923e-04-0.1869image
chr9:128329391-128332039:+LUSCJW.7.52.1EER2.3701e-04-0.1958image
ENSG00000167113.9,COQ4MESOBI.2536EAG1.1733e-020.3085image
chr9:128329391-128332039:+MESOBI.2536EER1.0952e-020.3113image
chr9:128326520-128327830:+OVAICAREER6.7115e-050.3052image
chr9:128329391-128332039:+OVAKT.inhibitor.VIIIEER2.8286e-070.3097image
ENSG00000167113.9,COQ4OVAZD6482EAG8.1641e-070.2975image
ENSG00000167113.9,COQ4PAADJNJ.26854165EAG2.0702e-02-0.1940image
chr9:128326520-128327830:+PAADAZD6482EER2.6049e-02-0.3608image
chr9:128329391-128332039:+PAADJNJ.26854165EER2.1263e-02-0.1932image
chr9:128326520-128327830:+PCPGJNK.Inhibitor.VIIIEER1.2102e-02-0.3456image
ENSG00000167113.9,COQ4PCPGLenalidomideEAG5.1300e-040.2794image
chr9:128329391-128332039:+PCPGLenalidomideEER4.7910e-040.2808image
ENSG00000167113.9,COQ4PRADAZD7762EAG6.6718e-040.1680image
chr9:128329391-128332039:+PRADAZD7762EER4.3476e-040.1738image
chr9:128326520-128327830:+SARCJNK.9LEER4.2040e-020.4369image
chr9:128329391-128332039:+SARCBAY.61.3606EER9.0510e-030.2153image
ENSG00000167113.9,COQ4SARCBAY.61.3606EAG6.7351e-030.2226image
chr9:128329391-128332039:+SKCMGDC.0449EER5.5167e-030.1553image
chr9:128326520-128327830:+SKCMJNJ.26854165EER3.0346e-030.2684image
ENSG00000167113.9,COQ4SKCMGDC.0449EAG2.4226e-020.1260image
ENSG00000167113.9,COQ4STADBortezomibEAG3.9245e-06-0.2517image
chr9:128329391-128332039:+STADBortezomibEER4.7750e-06-0.2499image
chr9:128326520-128327830:+STADLFM.A13EER5.3512e-040.2403image
chr9:128329391-128332039:+TGCTAG.014699EER2.1688e-02-0.1967image
chr9:128326520-128327830:+TGCTLapatinibEER9.0363e-04-0.5743image
ENSG00000167113.9,COQ4TGCTMethotrexateEAG1.2435e-020.2138image
ENSG00000167113.9,COQ4THCACI.1040EAG2.9931e-06-0.2133image
chr9:128326520-128327830:+THCAAZD8055EER3.4455e-030.1727image
chr9:128329391-128332039:+THCACI.1040EER2.0918e-06-0.2168image
chr9:128326520-128327830:+THYMCHIR.99021EER7.9041e-030.4915image
chr9:128329391-128332039:+THYMAxitinibEER2.2896e-020.2209image
ENSG00000167113.9,COQ4THYMAxitinibEAG2.9392e-020.2117image
ENSG00000167113.9,COQ4UCECA.770041EAG2.1219e-03-0.2682image
chr9:128329391-128332039:+UCECA.770041EER2.2497e-03-0.2667image
chr9:128329391-128332039:+UCSBMS.509744EER1.6117e-020.4039image
ENSG00000167113.9,COQ4UCSBMS.509744EAG1.6999e-020.4009image
chr9:128329391-128332039:+UVMMG.132EER4.3874e-02-0.3245image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType