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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: MECR (ImmuneEditome ID:51102)

1. Gene summary of enriched editing regions for MECR

check button Gene summary
Gene informationGene symbol

MECR

Gene ID

51102

GeneSynonymsCGI-63|DYTOABG|ETR1|FASN2B|NRBF1
GeneCytomap

1p35.3

GeneTypeprotein-coding
GeneDescriptionenoyl-[acyl-carrier-protein] reductase, mitochondrial|2-enoyl thioester reductase|homolog of yeast 2-enoyl thioester reductase|mitochondrial 2-enoyl thioester reductase|nuclear receptor binding factor 1|trans-2-enoyl-CoA reductase, mitochondrial
GeneModificationdate20230329
UniprotIDQ9BV79;H3BM30
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr1:29192938-29193267:-ENST00000373791.6ENSG00000116353.14MECRUTR3MER20,AluJbchr1:29192938-29193267:-.alignment


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2. Tumor-specific enriched editing regions for MECR


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check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr1:29192938-29193267:-BRCAEER1.1213e-03image
ENSG00000116353.14,MECRBRCAEAG9.9207e-04image
ENSG00000116353.14,MECRKIRCEAG5.4831e-05image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for MECR


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for MECR


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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5. Enriched editing regions and immune infiltration for MECR


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000116353.14,MECRBLCAEAGT_cells_regulatory_(Tregs)5.2804e-03-0.2406image
chr1:29192938-29193267:-BRCAEERT_cells_follicular_helper4.1375e-04-0.1559image
ENSG00000116353.14,MECRBRCAEAGT_cells_follicular_helper3.6038e-04-0.1574image
chr1:29192938-29193267:-CESCEERDendritic_cells_resting3.5811e-030.2429image
ENSG00000116353.14,MECRCESCEAGDendritic_cells_resting3.5811e-030.2429image
ENSG00000116353.14,MECRESCAEAGPlasma_cells1.9864e-02-0.2189image
ENSG00000116353.14,MECRGBMEAGMacrophages_M22.0452e-02-0.1951image
ENSG00000116353.14,MECRHNSCEAGB_cells_memory5.4718e-03-0.3157image
ENSG00000116353.14,MECRKICHEAGMonocytes2.4881e-02-0.4475image
ENSG00000116353.14,MECRKIRCEAGB_cells_memory3.9940e-02-0.1732image
chr1:29192938-29193267:-KIRPEERT_cells_regulatory_(Tregs)1.8614e-02-0.1777image
ENSG00000116353.14,MECRKIRPEAGT_cells_regulatory_(Tregs)1.8614e-02-0.1777image
ENSG00000116353.14,MECRLGGEAGT_cells_follicular_helper3.8158e-020.1024image
ENSG00000116353.14,MECRLIHCEAGMacrophages_M21.2343e-02-0.3661image
ENSG00000116353.14,MECRLUADEAGT_cells_CD83.9664e-050.3522image
chr1:29192938-29193267:-OVEERNeutrophils4.1877e-030.1754image
ENSG00000116353.14,MECROVEAGNeutrophils3.2727e-030.1800image
ENSG00000116353.14,MECRPAADEAGPlasma_cells1.5655e-020.3544image
chr1:29192938-29193267:-PRADEERPlasma_cells1.3234e-03-0.2458image
ENSG00000116353.14,MECRPRADEAGPlasma_cells1.3234e-03-0.2458image
ENSG00000116353.14,MECRSARCEAGB_cells_memory4.7939e-03-0.2591image
chr1:29192938-29193267:-SKCMEERMonocytes9.0029e-030.1866image
ENSG00000116353.14,MECRSKCMEAGMonocytes8.9503e-030.1863image
ENSG00000116353.14,MECRTGCTEAGMacrophages_M21.4430e-020.2440image
ENSG00000116353.14,MECRTHYMEAGMast_cells_activated4.0990e-020.2647image
ENSG00000116353.14,MECRUCECEAGT_cells_regulatory_(Tregs)1.0872e-020.2431image
ENSG00000116353.14,MECRUCSEAGDendritic_cells_resting1.4813e-020.3611image
ENSG00000116353.14,MECRUVMEAGNK_cells_resting3.0261e-020.3961image


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6. Enriched editing regions and immune gene sets for MECR


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000116353.14,MECRBLCAGSVA_HALLMARK_UV_RESPONSE_DNEAG2.4584e-040.3129image
chr1:29192938-29193267:-BRCAGSVA_HALLMARK_ANDROGEN_RESPONSEEER2.2078e-070.2272image
ENSG00000116353.14,MECRBRCAGSVA_HALLMARK_ANDROGEN_RESPONSEEAG4.5605e-070.2211image
ENSG00000116353.14,MECRCESCGSVA_HALLMARK_HEME_METABOLISMEAG1.6255e-030.2621image
chr1:29192938-29193267:-CESCGSVA_HALLMARK_HEME_METABOLISMEER1.6255e-030.2621image
ENSG00000116353.14,MECRCOADGSVA_HALLMARK_GLYCOLYSISEAG1.7962e-02-0.3978image
ENSG00000116353.14,MECRGBMGSVA_HALLMARK_SPERMATOGENESISEAG6.5175e-030.2281image
ENSG00000116353.14,MECRHNSCGSVA_HALLMARK_NOTCH_SIGNALINGEAG2.9339e-020.2501image
ENSG00000116353.14,MECRKICHGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.0800e-02-0.5007image
ENSG00000116353.14,MECRKIRCGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.1229e-030.2716image
ENSG00000116353.14,MECRLGGGSVA_HALLMARK_E2F_TARGETSEAG1.6529e-04-0.1850image
ENSG00000116353.14,MECRLUADGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG8.5655e-030.2297image
ENSG00000116353.14,MECRLUSCGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG5.9819e-030.2653image
chr1:29192938-29193267:-OVGSVA_HALLMARK_KRAS_SIGNALING_UPEER5.4918e-090.3486image
ENSG00000116353.14,MECROVGSVA_HALLMARK_KRAS_SIGNALING_UPEAG6.8564e-090.3465image
ENSG00000116353.14,MECRPAADGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG2.1133e-02-0.3391image
ENSG00000116353.14,MECRPCPGGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.0727e-02-0.2634image
chr1:29192938-29193267:-PCPGGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.0727e-02-0.2634image
ENSG00000116353.14,MECRSARCGSVA_HALLMARK_UV_RESPONSE_DNEAG1.1184e-040.3496image
ENSG00000116353.14,MECRSTADGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG2.3442e-030.2084image
ENSG00000116353.14,MECRTGCTGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG1.6985e-040.3674image
ENSG00000116353.14,MECRTHCAGSVA_HALLMARK_HEME_METABOLISMEAG2.4557e-030.1734image
chr1:29192938-29193267:-UCECGSVA_HALLMARK_KRAS_SIGNALING_DNEER9.6388e-030.2481image
ENSG00000116353.14,MECRUCECGSVA_HALLMARK_MYOGENESISEAG8.1076e-030.2524image
ENSG00000116353.14,MECRUCSGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG1.0528e-030.4723image


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7. Enriched editing regions and drugs for MECR


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000116353.14,MECRBLCAAZD.0530EAG1.5928e-03-0.2712image
ENSG00000116353.14,MECRBRCACCT007093EAG2.0417e-07-0.2276image
chr1:29192938-29193267:-BRCACCT007093EER2.3942e-07-0.2265image
chr1:29192938-29193267:-CESCGDC.0449EER4.3315e-050.3361image
ENSG00000116353.14,MECRCESCGDC.0449EAG4.3315e-050.3361image
ENSG00000116353.14,MECRCOADAZ628EAG1.0468e-050.6705image
ENSG00000116353.14,MECRESCAJW.7.52.1EAG1.3755e-020.2312image
ENSG00000116353.14,MECRGBMBryostatin.1EAG2.4011e-020.1900image
ENSG00000116353.14,MECRHNSCElesclomolEAG4.0984e-030.3256image
ENSG00000116353.14,MECRKICHMetforminEAG9.1486e-040.6214image
ENSG00000116353.14,MECRKIRCAZ628EAG7.0125e-04-0.2821image
chr1:29192938-29193267:-KIRPAZD6244EER3.0849e-030.2225image
ENSG00000116353.14,MECRKIRPAZD6244EAG3.0849e-030.2225image
ENSG00000116353.14,MECRLGGDocetaxelEAG2.0473e-040.1824image
ENSG00000116353.14,MECRLIHCAZD.0530EAG3.6389e-02-0.3406image
ENSG00000116353.14,MECRLUADCI.1040EAG2.6002e-02-0.1953image
ENSG00000116353.14,MECRLUSCMG.132EAG1.4925e-03-0.3047image
chr1:29192938-29193267:-OVCI.1040EER2.6718e-04-0.2222image
ENSG00000116353.14,MECROVCI.1040EAG3.2560e-04-0.2191image
ENSG00000116353.14,MECRPAADElesclomolEAG2.0765e-02-0.3400image
chr1:29192938-29193267:-PCPGEpothilone.BEER7.2943e-040.3442image
ENSG00000116353.14,MECRPCPGEpothilone.BEAG7.2943e-040.3442image
chr1:29192938-29193267:-PRADCamptothecinEER8.1193e-040.2560image
ENSG00000116353.14,MECRPRADCamptothecinEAG8.1193e-040.2560image
ENSG00000116353.14,MECRSARCDMOGEAG1.4100e-05-0.3896image
ENSG00000116353.14,MECRSKCMBMS.754807EAG3.0304e-02-0.1548image
chr1:29192938-29193267:-SKCMBMS.754807EER2.8924e-02-0.1565image
ENSG00000116353.14,MECRSTADLFM.A13EAG1.5659e-03-0.2164image
ENSG00000116353.14,MECRTGCTKIN001.135EAG1.0188e-03-0.3237image
ENSG00000116353.14,MECRTHCAGW843682XEAG1.2735e-070.2978image
ENSG00000116353.14,MECRTHYMAMG.706EAG3.8833e-030.3674image
ENSG00000116353.14,MECRUCECLFM.A13EAG2.1839e-02-0.2195image
chr1:29192938-29193267:-UCECGSK269962AEER2.1773e-02-0.2206image
ENSG00000116353.14,MECRUCSGW843682XEAG5.1932e-040.4967image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType