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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: POLR1D (ImmuneEditome ID:51082)

1. Gene summary of enriched editing regions for POLR1D

check button Gene summary
Gene informationGene symbol

POLR1D

Gene ID

51082

GeneSynonymsAC19|POLR1C|RPA16|RPA9|RPAC2|RPC16|RPO1-3|TCS2
GeneCytomap

13q12.2

GeneTypeprotein-coding
GeneDescriptionDNA-directed RNA polymerases I and III subunit RPAC2|Protein POLR1D|DNA-directed RNA polymerase I subunit D|RNA polymerase I subunit D|RNA polymerases I and III subunit AC2|polymerase (RNA) I polypeptide D, 16kDa|polymerase (RNA) I subunit D
GeneModificationdate20230409
UniprotIDP0DPB6;P0DPB5;A0A087WTY1;Q7Z776;A0A087X0U2;A0A1B0GUZ5;A0A8I5QL02;A0A0R4J2F3;A0A8I5KX40
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr13:27651596-27654142:+ENST00000472179.2ENSG00000186184.14POLR1DncRNA_intronicAluSz,AluSg7,Charlie1a,MLT1J,MIRbchr13:27651596-27654142:+.alignment


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2. Tumor-specific enriched editing regions for POLR1D


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr13:27651596-27654142:+BRCAEER9.7898e-03image
ENSG00000186184.14,POLR1DBRCAEAG1.3021e-02image
chr13:27651596-27654142:+PRADEER2.3040e-03image
ENSG00000186184.14,POLR1DPRADEAG2.3040e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr13:27651596-27654142:+CESCCliEER5.5121e-036.3833e-040.2822image
ENSG00000186184.14,POLR1DCESCCliEAG5.5121e-036.3833e-040.2822image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for POLR1D


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr13:27651596-27654142:+COADEERENSG00000203880,PCMTD2-0.43405.4561e-073.9078e-09-0.4040imageNELAVL1;FBL;HNRNPC;HNRNPK;HNRNPM;NOP56;PTBP1;UPF1NAEosinophilsGSVA_HALLMARK_GLYCOLYSIS
chr13:27651596-27654142:+ESCAEERENSG00000128284,APOL30.29873.7262e-021.4104e-060.4084imageNELAVL1;HNRNPC;HNRNPK;HNRNPM;PTBP1;UPF1NAMacrophages_M1GSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr13:27651596-27654142:+THYMEERENSG00000100387,RBX1-0.53167.3366e-067.5825e-09-0.5579imageNELAVL1;FBL;HNRNPC;HNRNPK;HNRNPM;NOP56;PTBP1;UPF1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr13:27651596-27654142:+THYMEERENSG00000148950,IMMP1L-0.54001.0235e-052.8110e-09-0.5709imageNELAVL1;FBL;HNRNPC;HNRNPK;HNRNPM;NOP56;PTBP1;UPF1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr13:27651596-27654142:+THYMEERENSG00000273064,RP11-474G23.3-0.52171.7507e-057.9164e-07-0.4883imageNUPF1NAMacrophages_M1GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr13:27651596-27654142:+THYMEERENSG00000272906,RP11-533E19.7-0.50542.4890e-055.2410e-08-0.5308imageNELAVL1;HNRNPC;NOP56NAMacrophages_M1GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr13:27651596-27654142:+THYMEERENSG00000180822,PSMG4-0.51443.2684e-053.7921e-07-0.5004imageNELAVL1;FBL;HNRNPC;HNRNPK;HNRNPM;NOP56;PTBP1;UPF1PSMG4Macrophages_M1GSVA_HALLMARK_PROTEIN_SECRETION
chr13:27651596-27654142:+THYMEERENSG00000273402,RP5-855D21.2-0.51783.2791e-057.9381e-06-0.4470imageNELAVL1;HNRNPC;NOP56NAMacrophages_M1GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr13:27651596-27654142:+THYMEERENSG00000267698,AC002116.7-0.49763.3712e-051.2163e-09-0.5815imageNELAVL1;FBL;HNRNPC;HNRNPK;NOP56;PTBP1;UPF1NAMacrophages_M1GSVA_HALLMARK_HEDGEHOG_SIGNALING
chr13:27651596-27654142:+THYMEERENSG00000276148,RP11-278C7.4-0.51563.4238e-053.8989e-07-0.4999imageNELAVL1;FBLNAMacrophages_M1GSVA_HALLMARK_PROTEIN_SECRETION

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4. Enriched editing regions and immune related splicing for POLR1D


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000186184.14,POLR1D
COADEAGIRENSG00000134884.9chr13106557047:106557131:106559431:106559657-0.44886.8773e-078.2224e-10-0.4198imageNACIN1;AIFM1;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM47;RC3H1;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZFP36;ZNF184NAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr13:27651596-27654142:+
COADEERIRENSG00000147162.9chrX71544566:71544635:71547906:71548023-0.40976.4769e-063.6481e-09-0.4057imageNELAVL1;FBL;HNRNPC;HNRNPK;HNRNPM;NOP56;PTBP1;UPF1NAEosinophilsGSVA_HALLMARK_HEME_METABOLISM
chr13:27651596-27654142:+
COADEERIRENSG00000102081.9chrX147943130:147943326:147944904:147945051-0.33874.7314e-055.4958e-08-0.4135imageNELAVL1;FBL;HNRNPC;HNRNPK;HNRNPM;NOP56;PTBP1;UPF1NAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr13:27651596-27654142:+
COADEERIRENSG00000134884.9chr13106557047:106557131:106559431:106559657-0.44844.9223e-077.1784e-10-0.4211imageNELAVL1;FBL;HNRNPC;HNRNPK;HNRNPM;NOP56;PTBP1;UPF1NAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000186184.14,POLR1D
COADEAGIRENSG00000007392.12chr16227241:227336:229278:229374-0.42255.0005e-061.5589e-09-0.4144imageNACIN1;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RC3H1;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YWHAG;ZC3H7B;ZFP36;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000186184.14,POLR1D
COADEAGIRENSG00000147162.9chrX71544566:71544635:71547906:71548023-0.40949.9122e-064.1105e-09-0.4045imageNACIN1;AIFM1;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM47;RC3H1;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZFP36;ZNF184NAEosinophilsGSVA_HALLMARK_HEME_METABOLISM
chr13:27651596-27654142:+
COADEERIRENSG00000182944.13chr2229288605:29289062:29291564:29291599-0.21148.7046e-033.4475e-09-0.4183imageNELAVL1;FBL;HNRNPC;HNRNPK;HNRNPM;NOP56;PTBP1;UPF1NAT_cells_follicular_helperGSVA_HALLMARK_MTORC1_SIGNALING
chr13:27651596-27654142:+
COADEERIRENSG00000007392.12chr16227241:227336:229278:229374-0.42233.4215e-061.3828e-09-0.4156imageNELAVL1;FBL;HNRNPC;HNRNPK;HNRNPM;NOP56;PTBP1;UPF1NAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000186184.14,POLR1D
COADEAGIRENSG00000102081.9chrX147943130:147943326:147944904:147945051-0.33817.0604e-056.7974e-08-0.4109imageNACIN1;AIFM1;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM47;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000186184.14,POLR1D
COADEAGIRENSG00000182944.13chr2229288605:29289062:29291564:29291599-0.21081.0628e-023.4720e-09-0.4182imageNACIN1;AIFM1;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM47;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAT_cells_follicular_helperGSVA_HALLMARK_MTORC1_SIGNALING

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5. Enriched editing regions and immune infiltration for POLR1D


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr13:27651596-27654142:+ACCEERMonocytes3.9253e-02-0.3552image
ENSG00000186184.14,POLR1DACCEAGMonocytes3.9253e-02-0.3552image
chr13:27651596-27654142:+BLCAEERT_cells_CD4_memory_activated1.4604e-030.2133image
ENSG00000186184.14,POLR1DBLCAEAGT_cells_CD4_memory_activated1.4536e-030.2134image
chr13:27651596-27654142:+BRCAEERMacrophages_M13.8415e-030.1287image
ENSG00000186184.14,POLR1DBRCAEAGMacrophages_M12.5602e-030.1341image
chr13:27651596-27654142:+COADEERT_cells_regulatory_(Tregs)1.0961e-020.1809image
ENSG00000186184.14,POLR1DCOADEAGT_cells_regulatory_(Tregs)1.1226e-020.1803image
chr13:27651596-27654142:+DLBCEERT_cells_CD81.2536e-02-0.4918image
ENSG00000186184.14,POLR1DDLBCEAGT_cells_CD81.2536e-02-0.4918image
chr13:27651596-27654142:+HNSCEERNK_cells_resting2.1386e-020.1635image
ENSG00000186184.14,POLR1DHNSCEAGNK_cells_resting2.1386e-020.1635image
chr13:27651596-27654142:+KIRCEERT_cells_CD4_memory_resting1.6293e-02-0.1879image
ENSG00000186184.14,POLR1DKIRCEAGT_cells_CD4_memory_resting1.6293e-02-0.1879image
chr13:27651596-27654142:+KIRPEERB_cells_naive2.7710e-030.4030image
ENSG00000186184.14,POLR1DKIRPEAGB_cells_naive2.7710e-030.4030image
chr13:27651596-27654142:+LAMLEERT_cells_follicular_helper5.2268e-040.4215image
ENSG00000186184.14,POLR1DLAMLEAGT_cells_follicular_helper5.2671e-040.4213image
chr13:27651596-27654142:+LIHCEERMast_cells_resting1.8149e-020.3297image
ENSG00000186184.14,POLR1DLIHCEAGMast_cells_resting1.8149e-020.3297image
chr13:27651596-27654142:+LUADEERNK_cells_activated1.1788e-020.2065image
ENSG00000186184.14,POLR1DLUADEAGNK_cells_activated1.1722e-020.2067image
chr13:27651596-27654142:+OVEERMacrophages_M21.3721e-020.2590image
ENSG00000186184.14,POLR1DOVEAGMacrophages_M21.4616e-020.2552image
chr13:27651596-27654142:+PAADEERMast_cells_activated2.6460e-020.3138image
ENSG00000186184.14,POLR1DPAADEAGMast_cells_activated2.6460e-020.3138image
chr13:27651596-27654142:+PCPGEERT_cells_CD81.4882e-030.3199image
ENSG00000186184.14,POLR1DPCPGEAGT_cells_CD81.4882e-030.3199image
chr13:27651596-27654142:+PRADEERB_cells_memory2.0767e-03-0.1466image
ENSG00000186184.14,POLR1DPRADEAGB_cells_memory2.0767e-03-0.1466image
chr13:27651596-27654142:+READEERT_cells_gamma_delta8.4622e-030.3040image
ENSG00000186184.14,POLR1DREADEAGT_cells_gamma_delta8.4622e-030.3040image
chr13:27651596-27654142:+SARCEERMacrophages_M13.6344e-020.3774image
ENSG00000186184.14,POLR1DSARCEAGMacrophages_M13.6344e-020.3774image
chr13:27651596-27654142:+SKCMEERB_cells_naive3.0180e-02-0.1594image
ENSG00000186184.14,POLR1DSKCMEAGB_cells_naive3.0180e-02-0.1594image
chr13:27651596-27654142:+STADEERMast_cells_resting3.8379e-020.1361image
ENSG00000186184.14,POLR1DSTADEAGMast_cells_resting3.8379e-020.1361image
chr13:27651596-27654142:+THYMEERT_cells_follicular_helper2.1870e-03-0.3155image
ENSG00000186184.14,POLR1DTHYMEAGT_cells_follicular_helper2.1870e-03-0.3155image


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6. Enriched editing regions and immune gene sets for POLR1D


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000186184.14,POLR1DBLCAEAG1.3422e-030.21493.7679e-040.23765.0081e-040.23272.9645e-050.2776image
chr13:27651596-27654142:+BLCAEER1.3437e-030.21493.8093e-040.23755.0550e-040.23262.9290e-050.2778image
ENSG00000186184.14,POLR1DKIRCEAG2.1990e-040.28561.7822e-020.18541.0645e-020.19968.2815e-060.3412image
chr13:27651596-27654142:+KIRCEER2.1990e-040.28561.7822e-020.18541.0645e-020.19968.2815e-060.3412image
ENSG00000186184.14,POLR1DPRADEAG1.5195e-020.11581.7469e-030.14909.1286e-040.15771.1580e-040.1830image
chr13:27651596-27654142:+PRADEER1.5195e-020.11581.7469e-030.14909.1286e-040.15771.1580e-040.1830image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr13:27651596-27654142:+BLCAGSVA_HALLMARK_UV_RESPONSE_UPEER9.5609e-090.3748image
ENSG00000186184.14,POLR1DBLCAGSVA_HALLMARK_UV_RESPONSE_UPEAG1.0008e-080.3744image
chr13:27651596-27654142:+BRCAGSVA_HALLMARK_PEROXISOMEEER3.2555e-080.2433image
ENSG00000186184.14,POLR1DBRCAGSVA_HALLMARK_PEROXISOMEEAG7.1041e-090.2542image
chr13:27651596-27654142:+CESCGSVA_HALLMARK_DNA_REPAIREER1.3231e-02-0.2075image
ENSG00000186184.14,POLR1DCESCGSVA_HALLMARK_DNA_REPAIREAG1.3231e-02-0.2075image
ENSG00000186184.14,POLR1DCOADGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG6.9317e-090.3980image
chr13:27651596-27654142:+COADGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER6.9494e-090.3980image
chr13:27651596-27654142:+DLBCGSVA_HALLMARK_ANDROGEN_RESPONSEEER8.9770e-040.6222image
ENSG00000186184.14,POLR1DDLBCGSVA_HALLMARK_ANDROGEN_RESPONSEEAG8.9770e-040.6222image
ENSG00000186184.14,POLR1DESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.7013e-040.3076image
chr13:27651596-27654142:+ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.6595e-040.3079image
chr13:27651596-27654142:+HNSCGSVA_HALLMARK_COMPLEMENTEER2.8792e-050.2926image
ENSG00000186184.14,POLR1DHNSCGSVA_HALLMARK_COMPLEMENTEAG2.8792e-050.2926image
chr13:27651596-27654142:+KICHGSVA_HALLMARK_HEME_METABOLISMEER2.3395e-020.3338image
ENSG00000186184.14,POLR1DKICHGSVA_HALLMARK_HEME_METABOLISMEAG2.3395e-020.3338image
chr13:27651596-27654142:+KIRCGSVA_HALLMARK_HYPOXIAEER8.2815e-060.3412image
ENSG00000186184.14,POLR1DKIRCGSVA_HALLMARK_HYPOXIAEAG8.2815e-060.3412image
chr13:27651596-27654142:+KIRPGSVA_HALLMARK_COMPLEMENTEER1.5270e-020.3316image
ENSG00000186184.14,POLR1DKIRPGSVA_HALLMARK_COMPLEMENTEAG1.5270e-020.3316image
chr13:27651596-27654142:+LAMLGSVA_HALLMARK_KRAS_SIGNALING_DNEER3.7027e-02-0.2613image
ENSG00000186184.14,POLR1DLAMLGSVA_HALLMARK_KRAS_SIGNALING_DNEAG3.5382e-02-0.2635image
ENSG00000186184.14,POLR1DLIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG3.9400e-040.4776image
chr13:27651596-27654142:+LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEER3.9400e-040.4776image
chr13:27651596-27654142:+LUADGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER3.6990e-030.2372image
ENSG00000186184.14,POLR1DLUADGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG3.6444e-030.2376image
chr13:27651596-27654142:+LUSCGSVA_HALLMARK_BILE_ACID_METABOLISMEER2.8591e-020.1450image
ENSG00000186184.14,POLR1DLUSCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG2.8591e-020.1450image
chr13:27651596-27654142:+PCPGGSVA_HALLMARK_G2M_CHECKPOINTEER2.2776e-030.3079image
ENSG00000186184.14,POLR1DPCPGGSVA_HALLMARK_G2M_CHECKPOINTEAG2.2776e-030.3079image
chr13:27651596-27654142:+PRADGSVA_HALLMARK_HEME_METABOLISMEER1.4152e-110.3151image
ENSG00000186184.14,POLR1DPRADGSVA_HALLMARK_HEME_METABOLISMEAG1.4152e-110.3151image
ENSG00000186184.14,POLR1DREADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.2416e-030.3378image
chr13:27651596-27654142:+READGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.2416e-030.3378image
ENSG00000186184.14,POLR1DSARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.6663e-020.3768image
chr13:27651596-27654142:+SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.6663e-020.3768image
chr13:27651596-27654142:+SKCMGSVA_HALLMARK_PEROXISOMEEER2.6625e-040.2650image
ENSG00000186184.14,POLR1DSKCMGSVA_HALLMARK_PEROXISOMEEAG2.6625e-040.2650image
ENSG00000186184.14,POLR1DSTADGSVA_HALLMARK_MYOGENESISEAG3.4632e-020.1388image
chr13:27651596-27654142:+STADGSVA_HALLMARK_MYOGENESISEER3.4632e-020.1388image
ENSG00000186184.14,POLR1DTGCTGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG4.4173e-020.4543image
ENSG00000186184.14,POLR1DTHCAGSVA_HALLMARK_APICAL_JUNCTIONEAG1.7818e-030.2789image
chr13:27651596-27654142:+THCAGSVA_HALLMARK_APICAL_JUNCTIONEER1.7818e-030.2789image
chr13:27651596-27654142:+THYMGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER9.4783e-060.4436image
ENSG00000186184.14,POLR1DTHYMGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG9.4783e-060.4436image
chr13:27651596-27654142:+UCECGSVA_HALLMARK_KRAS_SIGNALING_DNEER2.4053e-020.2797image
ENSG00000186184.14,POLR1DUCECGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.7755e-020.2932image


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7. Enriched editing regions and drugs for POLR1D


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000186184.14,POLR1DACCGDC.0449EAG4.0463e-020.3532image
chr13:27651596-27654142:+ACCGDC.0449EER4.0463e-020.3532image
chr13:27651596-27654142:+BLCAAxitinibEER3.5182e-060.3069image
ENSG00000186184.14,POLR1DBLCAAxitinibEAG3.5002e-060.3069image
chr13:27651596-27654142:+BRCAMG.132EER2.8126e-03-0.1333image
ENSG00000186184.14,POLR1DBRCAMG.132EAG2.1391e-03-0.1369image
chr13:27651596-27654142:+CESCCytarabineEER7.1834e-040.2806image
ENSG00000186184.14,POLR1DCESCCytarabineEAG7.1834e-040.2806image
chr13:27651596-27654142:+COADBI.D1870EER3.6578e-07-0.3529image
ENSG00000186184.14,POLR1DCOADBI.D1870EAG3.5586e-07-0.3532image
ENSG00000186184.14,POLR1DDLBCAZD6244EAG2.4246e-020.4493image
chr13:27651596-27654142:+DLBCAZD6244EER2.4246e-020.4493image
ENSG00000186184.14,POLR1DESCAAZD.2281EAG1.2132e-03-0.2808image
chr13:27651596-27654142:+ESCAAZD.2281EER1.2592e-03-0.2799image
chr13:27651596-27654142:+HNSCCI.1040EER1.3551e-03-0.2262image
ENSG00000186184.14,POLR1DHNSCCI.1040EAG1.3551e-03-0.2262image
ENSG00000186184.14,POLR1DKICHBMS.754807EAG4.8195e-04-0.4942image
chr13:27651596-27654142:+KICHBMS.754807EER4.8195e-04-0.4942image
ENSG00000186184.14,POLR1DKIRCCI.1040EAG4.4212e-03-0.2219image
chr13:27651596-27654142:+KIRCCI.1040EER4.4212e-03-0.2219image
chr13:27651596-27654142:+KIRPGW843682XEER6.8061e-030.3674image
ENSG00000186184.14,POLR1DKIRPGW843682XEAG6.8061e-030.3674image
chr13:27651596-27654142:+LIHCBleomycinEER1.6402e-030.4381image
ENSG00000186184.14,POLR1DLIHCBleomycinEAG1.6402e-030.4381image
ENSG00000186184.14,POLR1DLUADCamptothecinEAG1.9442e-020.1919image
chr13:27651596-27654142:+LUADCamptothecinEER1.9394e-020.1920image
chr13:27651596-27654142:+LUSCMetforminEER3.0547e-020.1433image
ENSG00000186184.14,POLR1DLUSCMetforminEAG3.0547e-020.1433image
chr13:27651596-27654142:+OVCCT018159EER9.1867e-03-0.2732image
ENSG00000186184.14,POLR1DOVCCT018159EAG1.3670e-02-0.2577image
chr13:27651596-27654142:+PCPGGDC0941EER1.1304e-030.3274image
ENSG00000186184.14,POLR1DPCPGGDC0941EAG1.1304e-030.3274image
chr13:27651596-27654142:+PRADCEP.701EER7.6886e-100.2882image
ENSG00000186184.14,POLR1DPRADCEP.701EAG7.6886e-100.2882image
ENSG00000186184.14,POLR1DREADBMS.708163EAG6.1477e-06-0.4986image
chr13:27651596-27654142:+READBMS.708163EER6.1477e-06-0.4986image
ENSG00000186184.14,POLR1DSARCAS601245EAG2.2176e-02-0.4094image
chr13:27651596-27654142:+SARCAS601245EER2.2176e-02-0.4094image
chr13:27651596-27654142:+SKCMBMS.536924EER1.0766e-020.1871image
ENSG00000186184.14,POLR1DSKCMBMS.536924EAG1.0766e-020.1871image
ENSG00000186184.14,POLR1DSTADBIBW2992EAG6.9446e-030.1787image
chr13:27651596-27654142:+STADBIBW2992EER6.9446e-030.1787image
ENSG00000186184.14,POLR1DTGCTMethotrexateEAG2.6501e-040.7291image
chr13:27651596-27654142:+THCAAxitinibEER2.3388e-020.2043image
ENSG00000186184.14,POLR1DTHCAAxitinibEAG2.3388e-020.2043image
chr13:27651596-27654142:+THYMAKT.inhibitor.VIIIEER8.0684e-08-0.5244image
ENSG00000186184.14,POLR1DTHYMAKT.inhibitor.VIIIEAG8.0684e-08-0.5244image
chr13:27651596-27654142:+UCECCMKEER2.7675e-04-0.4366image
ENSG00000186184.14,POLR1DUCECCMKEAG3.7442e-04-0.4281image
chr13:27651596-27654142:+UVMDasatinibEER4.5514e-03-0.5290image
ENSG00000186184.14,POLR1DUVMDasatinibEAG4.5514e-03-0.5290image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType