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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: FCF1 (ImmuneEditome ID:51077)

1. Gene summary of enriched editing regions for FCF1

check button Gene summary
Gene informationGene symbol

FCF1

Gene ID

51077

GeneSynonymsBka|C14orf111|CGI-35|UTP24
GeneCytomap

14q24.3

GeneTypeprotein-coding
GeneDescriptionrRNA-processing protein FCF1 homolog|FCF1 small subunit
GeneModificationdate20230405
UniprotIDQ9Y324;G3V1S4;G3V5S9;G3V5D2;G3V2M5;G3V5L8;G3V3N8
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr14:74735570-74738323:+ENST00000341162.7ENSG00000119616.10FCF1UTR3L1ME1,L1MA7,AluSp,L2c,MIR,AluSx,AluSc,AluJb,AluSc5,AluSzchr14:74735570-74738323:+.alignment


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2. Tumor-specific enriched editing regions for FCF1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr14:74735570-74738323:+BRCAEER9.7853e-17image
ENSG00000119616.10,FCF1BRCAEAG3.7964e-04image
chr14:74735570-74738323:+COADEER1.8700e-07image
ENSG00000119616.10,FCF1COADEAG1.8408e-07image
chr14:74735570-74738323:+HNSCEER2.1952e-14image
ENSG00000119616.10,FCF1HNSCEAG2.1952e-14image
chr14:74735570-74738323:+KIRCEER7.7799e-05image
chr14:74735570-74738323:+KIRPEER9.4376e-06image
ENSG00000119616.10,FCF1KIRPEAG1.8353e-04image
chr14:74735570-74738323:+LIHCEER1.9572e-02image
ENSG00000119616.10,FCF1LIHCEAG2.6945e-04image
chr14:74735570-74738323:+LUSCEER1.1930e-03image
ENSG00000119616.10,FCF1LUSCEAG1.2118e-03image
chr14:74735570-74738323:+THCAEER2.1329e-03image
ENSG00000119616.10,FCF1THCAEAG2.4300e-03image
chr14:74735570-74738323:+UCECEER7.0539e-03image
ENSG00000119616.10,FCF1UCECEAG7.0539e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000119616.10,FCF1KIRPPathEAG3.5983e-031.4615e-030.1979image
chr14:74735570-74738323:+KIRPPathEER1.6045e-031.9626e-030.1926image
ENSG00000119616.10,FCF1LIHCPathEAG4.0533e-021.6587e-02-0.1282image
chr14:74735570-74738323:+THCAPathEER2.5205e-024.7318e-020.0885image
ENSG00000119616.10,FCF1THCAPathEAG2.7107e-024.7999e-020.0882image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for FCF1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr14:74735570-74738323:+COADEERENSG00000243650,RN7SL834P0.24892.8787e-032.8135e-120.4112imageNNNAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr14:74735570-74738323:+COADEERENSG00000222009,BTBD190.21431.3028e-029.4728e-130.4193imageNNNANeutrophilsGSVA_HALLMARK_PEROXISOME
chr14:74735570-74738323:+COADEERENSG00000263050,RP11-667K14.30.21301.3847e-021.4839e-210.5402imageNNNANeutrophilsGSVA_HALLMARK_PEROXISOME
chr14:74735570-74738323:+COADEERENSG00000148737,TCF7L20.20801.5974e-021.2310e-120.4174imageNNTCF7L2Dendritic_cells_activatedGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr14:74735570-74738323:+COADEERENSG00000249019,RP11-539G18.10.17621.7901e-027.1089e-130.4214imageNNNAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr14:74735570-74738323:+COADEERENSG00000270640,RP11-373D23.20.19952.0835e-021.6188e-240.5720imageNNNANeutrophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr14:74735570-74738323:+COADEERENSG00000159733,ZFYVE280.20012.3900e-026.1873e-120.4052imageNNNAMacrophages_M0GSVA_HALLMARK_MYC_TARGETS_V1
chr14:74735570-74738323:+GBMEERENSG00000137628,DDX600.54433.0556e-095.2604e-100.4572imageNNNAMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr14:74735570-74738323:+GBMEERENSG00000137959,IFI44L0.51923.3500e-082.2969e-080.4158imageNNIFI44LMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr14:74735570-74738323:+GBMEERENSG00000135899,SP1100.50966.1694e-084.7662e-090.4337imageNNSP110Macrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE

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4. Enriched editing regions and immune related splicing for FCF1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000119616.10,FCF1
COADEAGIRENSG00000176890.11chr18667720:667752:669071:6691530.20343.4057e-028.5633e-110.4296imageNACIN1;ADAR;AUH;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPC;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;SAFB2;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;TAF15;TARBP2;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZFP36;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_UP
chr14:74735570-74738323:+
COADEERIRENSG00000124831.14chr2237768196:237772198:237772865:2377729450.22183.8159e-028.1845e-170.4851imageNNLRRFIP1EosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000119616.10,FCF1
COADEAGIRENSG00000187742.10chr989332587:89332986:89334635:893347300.23052.1358e-025.2908e-160.4898imageNACIN1;ADAR;AUH;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;SAFB2;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;TAF15;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZNF184NAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr14:74735570-74738323:+
COADEERIRENSG00000239857.2chr7887369:887519:890927:8910540.23532.2993e-023.3168e-330.6528imageNNNADendritic_cells_activatedGSVA_HALLMARK_UV_RESPONSE_UP
chr14:74735570-74738323:+
COADEERIRENSG00000116679.11chr1185301433:185306625:185307013:1853071390.23212.4847e-024.6972e-130.4296imageNNNANeutrophilsGSVA_HALLMARK_PEROXISOME
ENSG00000119616.10,FCF1
COADEAGIRENSG00000154122.8chr514704803:14713667:14716705:147168350.29371.2340e-031.2346e-130.4346imageNACIN1;ADAR;AUH;BUD13;CELF2;CNBP;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;MBNL2;MOV10;MSI1;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RBFOX2;RBM10;RBM27;RBM47;SAFB2;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;TAF15;TARBP2;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZFP36;ZNF184NANeutrophilsGSVA_HALLMARK_PEROXISOME
ENSG00000119616.10,FCF1
COADEAGIRENSG00000116679.11chr1185301433:185306625:185307013:1853071390.23212.8313e-024.6972e-130.4296imageNACIN1;ADAR;AUH;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;SAFB2;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;TAF15;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;ZFP36;ZNF184NANeutrophilsGSVA_HALLMARK_PEROXISOME
ENSG00000119616.10,FCF1
COADEAGIRENSG00000124831.14chr2237768196:237772198:237772865:2377729450.22184.2939e-028.1845e-170.4851imageNACIN1;ADAR;AUH;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;SAFB2;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;TAF15;TARBP2;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZFP36;ZNF184LRRFIP1EosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000119616.10,FCF1
COADEAGA5ENSG00000131771.9chr1739629169:39629230:39628497:39628582:39628497:396286220.21023.5332e-021.1516e-230.5797imageNDGCR8;FBL;FUS;MBNL2;TAF15NADendritic_cells_activatedGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
ENSG00000119616.10,FCF1
COADEAGIRENSG00000148120.10chr995080693:95080780:95082574:950825920.25141.2437e-025.5395e-160.4718imageNACIN1;ADAR;AUH;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MBNL1;MBNL2;MOV10;MSI1;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RBFOX2;RBM10;RBM27;RBM47;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;TAF15;TARBP2;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZNF184NAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP

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5. Enriched editing regions and immune infiltration for FCF1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr14:74735570-74738323:+ACCEERB_cells_memory1.9389e-020.2695image
ENSG00000119616.10,FCF1ACCEAGB_cells_memory1.9389e-020.2695image
chr14:74735570-74738323:+BLCAEERMacrophages_M19.5864e-060.2190image
ENSG00000119616.10,FCF1BLCAEAGMacrophages_M17.1059e-060.2221image
chr14:74735570-74738323:+BRCAEERMacrophages_M13.9023e-030.0878image
ENSG00000119616.10,FCF1BRCAEAGPlasma_cells5.1740e-03-0.0851image
chr14:74735570-74738323:+CESCEERMacrophages_M11.8139e-040.2131image
ENSG00000119616.10,FCF1CESCEAGMacrophages_M11.8139e-040.2131image
chr14:74735570-74738323:+COADEERMast_cells_activated2.6055e-030.1839image
ENSG00000119616.10,FCF1COADEAGMast_cells_activated2.6055e-030.1839image
chr14:74735570-74738323:+DLBCEERNeutrophils6.2279e-030.3894image
ENSG00000119616.10,FCF1DLBCEAGNeutrophils6.2279e-030.3894image
chr14:74735570-74738323:+ESCAEERDendritic_cells_resting3.8797e-03-0.2264image
ENSG00000119616.10,FCF1ESCAEAGDendritic_cells_resting3.8619e-03-0.2265image
chr14:74735570-74738323:+GBMEERMacrophages_M09.6327e-06-0.3350image
ENSG00000119616.10,FCF1GBMEAGMacrophages_M09.6327e-06-0.3350image
chr14:74735570-74738323:+HNSCEERMacrophages_M17.9552e-070.2188image
ENSG00000119616.10,FCF1HNSCEAGMacrophages_M17.9552e-070.2188image
ENSG00000119616.10,FCF1KICHEAGT_cells_CD4_memory_resting4.5923e-020.2566image
chr14:74735570-74738323:+KIRCEERT_cells_CD86.0278e-070.2520image
ENSG00000119616.10,FCF1KIRCEAGT_cells_CD81.1198e-060.2461image
chr14:74735570-74738323:+KIRPEERMacrophages_M11.3701e-030.1891image
ENSG00000119616.10,FCF1KIRPEAGMacrophages_M11.1887e-030.1914image
chr14:74735570-74738323:+LAMLEERT_cells_gamma_delta4.9537e-050.3736image
ENSG00000119616.10,FCF1LAMLEAGT_cells_gamma_delta1.1583e-040.3562image
chr14:74735570-74738323:+LGGEERMast_cells_resting1.1807e-030.1416image
ENSG00000119616.10,FCF1LGGEAGMast_cells_resting4.3847e-030.1245image
chr14:74735570-74738323:+LIHCEERMacrophages_M05.5053e-04-0.1783image
ENSG00000119616.10,FCF1LIHCEAGMacrophages_M02.4187e-04-0.1892image
chr14:74735570-74738323:+LUADEERT_cells_CD4_memory_activated3.2616e-030.1298image
ENSG00000119616.10,FCF1LUADEAGT_cells_CD4_memory_activated3.3143e-030.1296image
chr14:74735570-74738323:+LUSCEERMacrophages_M18.0005e-060.1986image
ENSG00000119616.10,FCF1LUSCEAGMacrophages_M17.6095e-060.1991image
chr14:74735570-74738323:+MESOEERT_cells_gamma_delta3.5912e-020.2321image
ENSG00000119616.10,FCF1MESOEAGT_cells_gamma_delta3.5912e-020.2321image
chr14:74735570-74738323:+OVEERMacrophages_M11.6179e-030.1840image
ENSG00000119616.10,FCF1OVEAGMacrophages_M11.6101e-030.1841image
chr14:74735570-74738323:+PAADEERNK_cells_activated2.7154e-03-0.2235image
ENSG00000119616.10,FCF1PAADEAGNK_cells_activated2.7154e-03-0.2235image
chr14:74735570-74738323:+PCPGEERMacrophages_M13.3886e-030.2179image
ENSG00000119616.10,FCF1PCPGEAGMacrophages_M13.3886e-030.2179image
chr14:74735570-74738323:+PRADEERT_cells_regulatory_(Tregs)2.0341e-060.2116image
ENSG00000119616.10,FCF1PRADEAGT_cells_regulatory_(Tregs)5.4581e-060.2027image
chr14:74735570-74738323:+READEERT_cells_CD4_memory_activated2.9928e-02-0.2253image
ENSG00000119616.10,FCF1READEAGT_cells_CD4_memory_activated2.9928e-02-0.2253image
chr14:74735570-74738323:+SARCEERT_cells_regulatory_(Tregs)4.7427e-030.1756image
ENSG00000119616.10,FCF1SARCEAGT_cells_regulatory_(Tregs)4.7427e-030.1756image
chr14:74735570-74738323:+SKCMEERT_cells_CD82.5251e-060.2153image
ENSG00000119616.10,FCF1SKCMEAGT_cells_CD82.5251e-060.2153image
chr14:74735570-74738323:+STADEERMacrophages_M04.0684e-04-0.1859image
ENSG00000119616.10,FCF1STADEAGMacrophages_M04.5369e-04-0.1844image
chr14:74735570-74738323:+TGCTEERMacrophages_M29.5766e-06-0.3462image
ENSG00000119616.10,FCF1TGCTEAGMacrophages_M29.5766e-06-0.3462image
chr14:74735570-74738323:+THCAEERMacrophages_M26.1454e-08-0.2383image
ENSG00000119616.10,FCF1THCAEAGMacrophages_M25.9999e-08-0.2385image
chr14:74735570-74738323:+THYMEERT_cells_CD4_naive1.0891e-08-0.4964image
ENSG00000119616.10,FCF1THYMEAGT_cells_CD4_naive1.0891e-08-0.4964image
chr14:74735570-74738323:+UCECEERDendritic_cells_resting8.4515e-03-0.1985image
ENSG00000119616.10,FCF1UCECEAGDendritic_cells_resting8.4515e-03-0.1985image
chr14:74735570-74738323:+UCSEERT_cells_CD4_memory_resting4.0689e-02-0.2769image
ENSG00000119616.10,FCF1UCSEAGT_cells_CD4_memory_resting4.0689e-02-0.2769image
chr14:74735570-74738323:+UVMEEREosinophils5.2891e-03-0.3148image
ENSG00000119616.10,FCF1UVMEAGEosinophils5.2891e-03-0.3148image


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6. Enriched editing regions and immune gene sets for FCF1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr14:74735570-74738323:+LUSCEER3.3822e-02image2.9305e-030.1330image
ENSG00000119616.10,FCF1LUSCEAG3.4451e-02image3.0317e-030.1326image
chr14:74735570-74738323:+THCAEER4.8822e-02image4.0521e-070.2234image
ENSG00000119616.10,FCF1THCAEAG4.8780e-02image4.9067e-070.2218image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000119616.10,FCF1ACCEAG3.1324e-03-0.33683.8442e-02-0.23961.9268e-04-0.41773.5944e-03-0.3322image
chr14:74735570-74738323:+ACCEER3.1324e-03-0.33683.8442e-02-0.23961.9268e-04-0.41773.5944e-03-0.3322image
chr14:74735570-74738323:+BLCAEER5.4679e-080.26735.5944e-060.22462.9984e-080.27238.3144e-050.1952image
ENSG00000119616.10,FCF1BLCAEAG4.0565e-080.26984.7242e-060.22632.2549e-080.27477.0424e-050.1972image
chr14:74735570-74738323:+PRADEER1.2095e-020.11273.8116e-030.12983.3043e-020.09583.1063e-030.1327image
ENSG00000119616.10,FCF1PRADEAG1.1689e-020.11322.8907e-030.13363.6897e-020.09385.0432e-030.1259image
chr14:74735570-74738323:+THYMEER7.6766e-06-0.39895.4207e-07-0.44205.7249e-030.25291.5751e-080.4916image
ENSG00000119616.10,FCF1THYMEAG7.6766e-06-0.39895.4207e-07-0.44205.7249e-030.25291.5751e-080.4916image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000119616.10,FCF1ACCGSVA_HALLMARK_ANDROGEN_RESPONSEEAG9.4411e-05-0.4354image
chr14:74735570-74738323:+ACCGSVA_HALLMARK_ANDROGEN_RESPONSEEER9.4411e-05-0.4354image
chr14:74735570-74738323:+BLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER2.6665e-100.3087image
ENSG00000119616.10,FCF1BLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.9208e-100.3110image
ENSG00000119616.10,FCF1BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.2934e-230.2957image
chr14:74735570-74738323:+BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.6192e-240.3012image
chr14:74735570-74738323:+CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER9.0463e-140.4102image
ENSG00000119616.10,FCF1CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG9.0463e-140.4102image
ENSG00000119616.10,FCF1COADGSVA_HALLMARK_SPERMATOGENESISEAG4.9357e-05-0.2462image
chr14:74735570-74738323:+COADGSVA_HALLMARK_SPERMATOGENESISEER4.9357e-05-0.2462image
chr14:74735570-74738323:+DLBCGSVA_HALLMARK_E2F_TARGETSEER3.4337e-02-0.3061image
ENSG00000119616.10,FCF1DLBCGSVA_HALLMARK_E2F_TARGETSEAG3.4337e-02-0.3061image
chr14:74735570-74738323:+ESCAGSVA_HALLMARK_PROTEIN_SECRETIONEER5.5743e-030.2175image
ENSG00000119616.10,FCF1ESCAGSVA_HALLMARK_PROTEIN_SECRETIONEAG5.6794e-030.2171image
chr14:74735570-74738323:+GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER7.4980e-080.4016image
ENSG00000119616.10,FCF1GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG7.4980e-080.4016image
chr14:74735570-74738323:+HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER7.1716e-210.4026image
ENSG00000119616.10,FCF1HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG7.1716e-210.4026image
ENSG00000119616.10,FCF1KIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.0379e-090.3058image
chr14:74735570-74738323:+KIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.4574e-100.3140image
chr14:74735570-74738323:+KIRPGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.2087e-050.2564image
ENSG00000119616.10,FCF1KIRPGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.8340e-060.2737image
chr14:74735570-74738323:+LAMLGSVA_HALLMARK_G2M_CHECKPOINTEER1.7064e-06-0.4344image
ENSG00000119616.10,FCF1LAMLGSVA_HALLMARK_G2M_CHECKPOINTEAG2.0938e-05-0.3903image
ENSG00000119616.10,FCF1LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG6.7856e-120.3459image
chr14:74735570-74738323:+LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEER7.5236e-100.3122image
ENSG00000119616.10,FCF1LUADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.9605e-03-0.1365image
chr14:74735570-74738323:+LUADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.8857e-03-0.1370image
ENSG00000119616.10,FCF1LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.3523e-190.3906image
chr14:74735570-74738323:+LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.3854e-190.3905image
chr14:74735570-74738323:+MESOGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER3.3958e-060.4875image
ENSG00000119616.10,FCF1MESOGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG3.3958e-060.4875image
ENSG00000119616.10,FCF1OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.9497e-100.3562image
chr14:74735570-74738323:+OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.0606e-100.3559image
ENSG00000119616.10,FCF1PAADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG5.7461e-050.2968image
chr14:74735570-74738323:+PAADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.7461e-050.2968image
chr14:74735570-74738323:+PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.5416e-060.3322image
ENSG00000119616.10,FCF1PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG5.5416e-060.3322image
ENSG00000119616.10,FCF1PRADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.7721e-130.3154image
chr14:74735570-74738323:+PRADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER9.6426e-140.3263image
ENSG00000119616.10,FCF1READGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG2.0201e-030.3162image
chr14:74735570-74738323:+READGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER2.0201e-030.3162image
chr14:74735570-74738323:+SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.2376e-070.3226image
ENSG00000119616.10,FCF1SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.2376e-070.3226image
chr14:74735570-74738323:+SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.6520e-110.2965image
ENSG00000119616.10,FCF1SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG5.6520e-110.2965image
chr14:74735570-74738323:+STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.5565e-090.3019image
ENSG00000119616.10,FCF1STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.7905e-090.3003image
ENSG00000119616.10,FCF1TGCTGSVA_HALLMARK_HEME_METABOLISMEAG8.1883e-07-0.3827image
chr14:74735570-74738323:+TGCTGSVA_HALLMARK_HEME_METABOLISMEER8.1883e-07-0.3827image
ENSG00000119616.10,FCF1THCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG8.7822e-220.4093image
chr14:74735570-74738323:+THCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER5.9845e-220.4109image
ENSG00000119616.10,FCF1THYMGSVA_HALLMARK_E2F_TARGETSEAG2.6864e-13-0.6085image
chr14:74735570-74738323:+THYMGSVA_HALLMARK_E2F_TARGETSEER2.6864e-13-0.6085image
chr14:74735570-74738323:+UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.2173e-060.3572image
ENSG00000119616.10,FCF1UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.2173e-060.3572image
ENSG00000119616.10,FCF1UCSGSVA_HALLMARK_HYPOXIAEAG1.0514e-040.4991image
chr14:74735570-74738323:+UCSGSVA_HALLMARK_HYPOXIAEER1.0514e-040.4991image
ENSG00000119616.10,FCF1UVMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG3.1666e-060.5028image
chr14:74735570-74738323:+UVMGSVA_HALLMARK_KRAS_SIGNALING_DNEER3.1666e-060.5028image


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7. Enriched editing regions and drugs for FCF1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000119616.10,FCF1ACCAG.014699EAG2.9361e-02-0.2517image
chr14:74735570-74738323:+ACCAG.014699EER2.9361e-02-0.2517image
chr14:74735570-74738323:+BLCAElesclomolEER2.4274e-100.3094image
ENSG00000119616.10,FCF1BLCAElesclomolEAG2.6520e-100.3087image
chr14:74735570-74738323:+BRCAEHT.1864EER3.3481e-050.1259image
ENSG00000119616.10,FCF1BRCAAZD6482EAG6.6920e-05-0.1212image
ENSG00000119616.10,FCF1CESCAZD6244EAG1.2714e-08-0.3191image
chr14:74735570-74738323:+CESCAZD6244EER1.2714e-08-0.3191image
chr14:74735570-74738323:+COADGefitinibEER8.9597e-05-0.2378image
ENSG00000119616.10,FCF1COADGefitinibEAG8.9597e-05-0.2378image
ENSG00000119616.10,FCF1DLBCAZD.2281EAG2.0985e-04-0.5105image
chr14:74735570-74738323:+DLBCAZD.2281EER2.0985e-04-0.5105image
ENSG00000119616.10,FCF1ESCAEHT.1864EAG1.1000e-020.1999image
chr14:74735570-74738323:+ESCAEHT.1864EER1.0780e-020.2005image
ENSG00000119616.10,FCF1GBMBIBW2992EAG1.0543e-06-0.3672image
chr14:74735570-74738323:+GBMBIBW2992EER1.0543e-06-0.3672image
ENSG00000119616.10,FCF1HNSCCI.1040EAG7.7551e-16-0.3501image
chr14:74735570-74738323:+HNSCCI.1040EER7.7551e-16-0.3501image
chr14:74735570-74738323:+KIRCGDC.0449EER3.8220e-09-0.2960image
ENSG00000119616.10,FCF1KIRCGDC.0449EAG1.2797e-08-0.2863image
chr14:74735570-74738323:+KIRPCCT018159EER5.9777e-070.2911image
ENSG00000119616.10,FCF1KIRPCCT018159EAG9.5973e-080.3101image
ENSG00000119616.10,FCF1LAMLA.443654EAG7.3293e-030.2521image
chr14:74735570-74738323:+LAMLA.443654EER1.2417e-030.3014image
chr14:74735570-74738323:+LGGJNJ.26854165EER2.2568e-020.0998image
ENSG00000119616.10,FCF1LGGJNJ.26854165EAG4.6729e-020.0871image
ENSG00000119616.10,FCF1LIHCAUY922EAG1.2563e-130.3716image
chr14:74735570-74738323:+LIHCAUY922EER1.1955e-130.3719image
ENSG00000119616.10,FCF1LUADEmbelinEAG1.5630e-04-0.1663image
chr14:74735570-74738323:+LUADEmbelinEER1.6002e-04-0.1661image
ENSG00000119616.10,FCF1LUSCCI.1040EAG3.2419e-09-0.2613image
chr14:74735570-74738323:+LUSCCI.1040EER3.3838e-09-0.2610image
chr14:74735570-74738323:+MESOGDC0941EER9.7719e-030.2838image
ENSG00000119616.10,FCF1MESOGDC0941EAG9.7719e-030.2838image
ENSG00000119616.10,FCF1OVMidostaurinEAG5.6484e-080.3117image
chr14:74735570-74738323:+OVMidostaurinEER5.7730e-080.3114image
ENSG00000119616.10,FCF1PAADA.770041EAG7.6656e-04-0.2534image
chr14:74735570-74738323:+PAADA.770041EER7.6656e-04-0.2534image
ENSG00000119616.10,FCF1PCPGFH535EAG2.0765e-030.2287image
chr14:74735570-74738323:+PCPGFH535EER2.0765e-030.2287image
ENSG00000119616.10,FCF1PRADJNK.Inhibitor.VIIIEAG2.6364e-08-0.2468image
chr14:74735570-74738323:+PRADBortezomibEER8.8575e-09-0.2549image
ENSG00000119616.10,FCF1READJNK.9LEAG6.2005e-03-0.2819image
chr14:74735570-74738323:+READJNK.9LEER6.2005e-03-0.2819image
chr14:74735570-74738323:+SARCCMKEER1.3530e-040.2359image
ENSG00000119616.10,FCF1SARCCMKEAG1.3530e-040.2359image
chr14:74735570-74738323:+SKCMCGP.082996EER3.7834e-05-0.1891image
ENSG00000119616.10,FCF1SKCMCGP.082996EAG3.7834e-05-0.1891image
ENSG00000119616.10,FCF1STADCI.1040EAG1.9417e-03-0.1633image
chr14:74735570-74738323:+STADCI.1040EER1.8367e-03-0.1641image
chr14:74735570-74738323:+TGCTLapatinibEER2.5248e-050.3304image
ENSG00000119616.10,FCF1TGCTLapatinibEAG2.5248e-050.3304image
ENSG00000119616.10,FCF1THCACI.1040EAG3.4710e-20-0.3942image
chr14:74735570-74738323:+THCACI.1040EER2.4165e-20-0.3957image
ENSG00000119616.10,FCF1THYMBleomycinEAG4.8858e-130.6032image
chr14:74735570-74738323:+THYMBleomycinEER4.8858e-130.6032image
chr14:74735570-74738323:+UCECABT.888EER8.2787e-05-0.2931image
ENSG00000119616.10,FCF1UCECABT.888EAG8.2787e-05-0.2931image
ENSG00000119616.10,FCF1UCSCGP.60474EAG1.8623e-05-0.5427image
chr14:74735570-74738323:+UCSCGP.60474EER1.8623e-05-0.5427image
ENSG00000119616.10,FCF1UVMGSK269962AEAG1.1721e-05-0.4767image
chr14:74735570-74738323:+UVMGSK269962AEER1.1721e-05-0.4767image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType