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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: PDCL (ImmuneEditome ID:5082)

1. Gene summary of enriched editing regions for PDCL

check button Gene summary
Gene informationGene symbol

PDCL

Gene ID

5082

GeneSynonymsPhLP
GeneCytomap

9q33.2

GeneTypeprotein-coding
GeneDescriptionphosducin-like protein
GeneModificationdate20230329
UniprotIDQ13371
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr9:122816256-122817760:-ENST00000436632.4ENSG00000136940.12PDCLintronicAluJb,MER5A,MIRb,MER1A,AluSx1chr9:122816256-122817760:-.alignment


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2. Tumor-specific enriched editing regions for PDCL


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr9:122816256-122817760:-BRCAEER5.2360e-03image
ENSG00000136940.12,PDCLBRCAEAG5.1523e-03image
ENSG00000136940.12,PDCLKICHEAG2.2999e-03image
chr9:122816256-122817760:-KIRCEER1.0716e-03image
ENSG00000136940.12,PDCLKIRCEAG1.0768e-03image
chr9:122816256-122817760:-STADEER2.6802e-02image
ENSG00000136940.12,PDCLSTADEAG4.0274e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000136940.12,PDCLUVMPathEAG1.9169e-021.2233e-02-0.4840image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
ENSG00000136940.12,PDCLKICHEAG2.6584e-023.8737e-021.6660e+10image

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3. Enriched editing regions and immune related genes for PDCL


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr9:122816256-122817760:-GBMEERENSG00000213923,CSNK1E-0.45271.0181e-051.3391e-07-0.4171imageNNNAMonocytesGSVA_HALLMARK_BILE_ACID_METABOLISM
chr9:122816256-122817760:-GBMEERENSG00000093009,CDC45-0.43773.7559e-051.1603e-08-0.4477imageNNNAMonocytesGSVA_HALLMARK_E2F_TARGETS
chr9:122816256-122817760:-GBMEERENSG00000185252,ZNF74-0.42923.9230e-055.4517e-08-0.4287imageNNNAMonocytesGSVA_HALLMARK_BILE_ACID_METABOLISM
chr9:122816256-122817760:-GBMEERENSG00000123609,NMI0.42058.3059e-053.0652e-070.4060imageNNNAMacrophages_M0GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr9:122816256-122817760:-GBMEERENSG00000163449,TMEM169-0.40541.3812e-046.6353e-08-0.4262imageNNNAT_cells_follicular_helperGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr9:122816256-122817760:-GBMEERENSG00000077279,DCX-0.39791.8315e-044.3493e-07-0.4012imageNNNAMacrophages_M0GSVA_HALLMARK_BILE_ACID_METABOLISM
chr9:122816256-122817760:-GBMEERENSG00000136891,TEX10-0.40042.1831e-042.7461e-08-0.4373imageNNNAMonocytesGSVA_HALLMARK_XENOBIOTIC_METABOLISM
chr9:122816256-122817760:-GBMEERENSG00000197951,ZNF71-0.40522.1840e-047.0139e-08-0.4255imageNNNAMonocytesGSVA_HALLMARK_BILE_ACID_METABOLISM
chr9:122816256-122817760:-GBMEERENSG00000245571,AP001258.40.39563.0809e-041.2804e-070.4177imageNNNAMonocytesGSVA_HALLMARK_BILE_ACID_METABOLISM
chr9:122816256-122817760:-GBMEERENSG00000136371,MTHFS0.38293.8119e-044.7099e-070.4001imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_FATTY_ACID_METABOLISM

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4. Enriched editing regions and immune related splicing for PDCL


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr9:122816256-122817760:-
ESCAEERIRENSG00000136040.4chr1294303755:94303896:94303976:94304051-0.35081.6772e-031.4858e-06-0.4246imageNNPLXNC1Macrophages_M1GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
ENSG00000136940.12,PDCL
ESCAEAGIRENSG00000136040.4chr1294303755:94303896:94303976:94304051-0.35051.9035e-031.2201e-06-0.4278imageNACIN1;ADAR;AUH;BUD13;CNBP;CSTF2T;DGCR8;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;LIN28B;MBNL2;MOV10;MSI2;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RBFOX2;RBM47;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF9;TAF15;TARDBP;TIA1;TRA2A;U2AF1;U2AF2;UPF1;YTHDC1PLXNC1Macrophages_M1GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
ENSG00000136940.12,PDCL
GBMEAGA3ENSG00000129353.10chr1910642366:10642451:10643278:10643398:10642896:106433980.39451.4583e-032.5191e-070.4086imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI2;NOP56;NOP58;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SLTM;SMNDC1;SND1;SRSF1;SRSF3;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZNF184NAT_cells_follicular_helperGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr9:122816256-122817760:-
GBMEERESENSG00000076351.8chr1728399345:28399713:28400609:28402321:28404615:284048210.34531.0437e-035.2506e-070.4442imageNNNAT_cells_follicular_helperGSVA_HALLMARK_BILE_ACID_METABOLISM
chr9:122816256-122817760:-
GBMEERA3ENSG00000076351.8chr1728404615:28404821:28394641:28399713:28394641:28402321-0.29441.3859e-025.1352e-06-0.4011imageNNNAT_cells_follicular_helperGSVA_HALLMARK_BILE_ACID_METABOLISM
ENSG00000136940.12,PDCL
GBMEAGIRENSG00000171962.13chr1718004362:18004494:18006182:18006253-0.28912.0933e-023.0175e-06-0.4249imageNADAR;DGCR8;DKC1;EIF4A3;ELAVL1;EWSR1;FBL;FMR1;FUS;GNL3;HNRNPA1;HNRNPC;IGF2BP1;IGF2BP2;KHDRBS1;LIN28;LIN28B;NOP56;NOP58;RANGAP1;RBFOX2;RBM10;RNF219;SMNDC1;SND1;SRSF1;TAF15;TARDBP;TROVE2;U2AF1;U2AF2;UPF1;YTHDF1;ZNF184NAMacrophages_M0GSVA_HALLMARK_BILE_ACID_METABOLISM
ENSG00000136940.12,PDCL
GBMEAGESENSG00000076351.8chr1728399345:28399713:28400609:28402321:28404615:284048210.34531.1876e-035.2506e-070.4442imageNADAR;AIFM1;AUH;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS2;KHSRP;LIN28;LIN28A;LIN28B;MOV10;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RNF219;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF9;TAF15;TARDBP;TIA1;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZFP36;ZNF184NAT_cells_follicular_helperGSVA_HALLMARK_BILE_ACID_METABOLISM
chr9:122816256-122817760:-
GBMEERIRENSG00000171962.13chr1718004362:18004494:18006182:18006253-0.28911.7944e-023.0175e-06-0.4249imageNNNAMacrophages_M0GSVA_HALLMARK_BILE_ACID_METABOLISM
ENSG00000136940.12,PDCL
GBMEAGESENSG00000108175.12chr1079307404:79307571:79310923:79311184:79312641:79312711-0.42003.5990e-042.0046e-09-0.4767imageNADAR;AIFM1;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS2;KHSRP;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI2;NOP56;NOP58;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RC3H1;RNF219;SND1;SRSF1;SRSF3;TAF15;TARDBP;TIA1;TIAL1;TROVE2;U2AF1;U2AF2;UPF1;YTHDC1;YTHDF1;ZC3H7B;ZFP36;ZNF184NAMacrophages_M0GSVA_HALLMARK_MITOTIC_SPINDLE
chr9:122816256-122817760:-
GBMEERESENSG00000108175.12chr1079307404:79307571:79310923:79311184:79312641:79312711-0.42003.2992e-042.0046e-09-0.4767imageNNNAMacrophages_M0GSVA_HALLMARK_MITOTIC_SPINDLE

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5. Enriched editing regions and immune infiltration for PDCL


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000136940.12,PDCLACCEAGT_cells_CD4_naive2.0714e-050.7035image
ENSG00000136940.12,PDCLCESCEAGT_cells_CD4_memory_resting1.3045e-030.2098image
chr9:122816256-122817760:-COADEERMacrophages_M03.8009e-020.1531image
ENSG00000136940.12,PDCLCOADEAGMacrophages_M03.8009e-020.1531image
ENSG00000136940.12,PDCLDLBCEAGT_cells_CD4_memory_resting4.6326e-020.3867image
chr9:122816256-122817760:-ESCAEERMacrophages_M16.7961e-030.2138image
ENSG00000136940.12,PDCLESCAEAGMacrophages_M18.0534e-030.2095image
chr9:122816256-122817760:-GBMEERMonocytes1.3069e-020.2036image
ENSG00000136940.12,PDCLGBMEAGMonocytes1.3069e-020.2036image
chr9:122816256-122817760:-HNSCEERNK_cells_resting9.6301e-030.1325image
ENSG00000136940.12,PDCLHNSCEAGNK_cells_resting8.9508e-030.1336image
chr9:122816256-122817760:-KIRCEERDendritic_cells_resting8.5911e-030.1417image
ENSG00000136940.12,PDCLKIRCEAGDendritic_cells_resting8.6021e-030.1417image
ENSG00000136940.12,PDCLLGGEAGT_cells_regulatory_(Tregs)4.4321e-030.1304image
chr9:122816256-122817760:-LIHCEERNK_cells_activated2.5525e-020.1915image
ENSG00000136940.12,PDCLLIHCEAGNK_cells_activated2.5953e-020.1910image
ENSG00000136940.12,PDCLLUADEAGMonocytes1.3993e-020.1273image
chr9:122816256-122817760:-LUSCEERPlasma_cells8.2387e-050.2063image
ENSG00000136940.12,PDCLLUSCEAGPlasma_cells7.9132e-050.2068image
ENSG00000136940.12,PDCLMESOEAGT_cells_follicular_helper2.1652e-03-0.4049image
chr9:122816256-122817760:-OVEERB_cells_naive1.8825e-02-0.1500image
ENSG00000136940.12,PDCLOVEAGB_cells_naive2.5278e-02-0.1429image
chr9:122816256-122817760:-PCPGEERNK_cells_resting3.1980e-050.3187image
ENSG00000136940.12,PDCLPCPGEAGNK_cells_resting3.1467e-050.3190image
ENSG00000136940.12,PDCLPRADEAGT_cells_CD4_memory_activated3.1368e-050.1945image
ENSG00000136940.12,PDCLREADEAGDendritic_cells_resting2.1755e-030.3764image
chr9:122816256-122817760:-SARCEERMast_cells_activated4.1226e-020.1441image
ENSG00000136940.12,PDCLSARCEAGMast_cells_activated4.0828e-020.1444image
ENSG00000136940.12,PDCLSKCMEAGMacrophages_M13.6224e-030.1635image
chr9:122816256-122817760:-STADEERT_cells_gamma_delta1.1697e-030.1821image
ENSG00000136940.12,PDCLSTADEAGT_cells_gamma_delta1.2067e-030.1816image
chr9:122816256-122817760:-THCAEERNeutrophils1.7364e-030.1535image
ENSG00000136940.12,PDCLTHCAEAGNeutrophils1.7507e-030.1534image
ENSG00000136940.12,PDCLUCECEAGDendritic_cells_activated3.1929e-020.1976image
ENSG00000136940.12,PDCLUCSEAGMast_cells_resting4.3824e-02-0.3333image
ENSG00000136940.12,PDCLUVMEAGMacrophages_M01.9832e-02-0.4456image


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6. Enriched editing regions and immune gene sets for PDCL


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000136940.12,PDCLPRADEAG4.8375e-020.09292.4832e-020.10563.3614e-020.10001.1706e-020.1185image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000136940.12,PDCLBLCAGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG1.9337e-020.1395image
ENSG00000136940.12,PDCLBRCAGSVA_HALLMARK_HEME_METABOLISMEAG1.8078e-050.1391image
chr9:122816256-122817760:-BRCAGSVA_HALLMARK_HEME_METABOLISMEER1.9161e-050.1387image
ENSG00000136940.12,PDCLCESCGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG1.8888e-020.1540image
ENSG00000136940.12,PDCLCHOLGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG1.9773e-02-0.4929image
chr9:122816256-122817760:-COADGSVA_HALLMARK_UV_RESPONSE_UPEER2.3496e-020.1670image
ENSG00000136940.12,PDCLCOADGSVA_HALLMARK_UV_RESPONSE_UPEAG2.3496e-020.1670image
ENSG00000136940.12,PDCLDLBCGSVA_HALLMARK_SPERMATOGENESISEAG8.7314e-030.4946image
chr9:122816256-122817760:-ESCAGSVA_HALLMARK_PROTEIN_SECRETIONEER5.0348e-050.3157image
ENSG00000136940.12,PDCLESCAGSVA_HALLMARK_PROTEIN_SECRETIONEAG6.6369e-050.3109image
ENSG00000136940.12,PDCLGBMGSVA_HALLMARK_BILE_ACID_METABOLISMEAG8.0346e-070.3925image
chr9:122816256-122817760:-GBMGSVA_HALLMARK_BILE_ACID_METABOLISMEER8.0346e-070.3925image
chr9:122816256-122817760:-HNSCGSVA_HALLMARK_P53_PATHWAYEER9.1979e-050.1990image
ENSG00000136940.12,PDCLHNSCGSVA_HALLMARK_P53_PATHWAYEAG8.5480e-050.1996image
ENSG00000136940.12,PDCLKIRCGSVA_HALLMARK_PEROXISOMEEAG3.2983e-040.1928image
chr9:122816256-122817760:-KIRCGSVA_HALLMARK_PEROXISOMEEER3.1596e-040.1934image
ENSG00000136940.12,PDCLKIRPGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.7140e-030.2235image
ENSG00000136940.12,PDCLLGGGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG1.6037e-040.1723image
chr9:122816256-122817760:-LIHCGSVA_HALLMARK_UV_RESPONSE_DNEER2.4334e-020.1930image
ENSG00000136940.12,PDCLLIHCGSVA_HALLMARK_UV_RESPONSE_DNEAG2.5097e-020.1920image
ENSG00000136940.12,PDCLLUADGSVA_HALLMARK_MTORC1_SIGNALINGEAG6.9064e-050.2048image
ENSG00000136940.12,PDCLOVGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG8.5286e-030.1677image
chr9:122816256-122817760:-OVGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEER1.2437e-020.1595image
ENSG00000136940.12,PDCLPAADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG8.7617e-04-0.2884image
chr9:122816256-122817760:-PAADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER8.7617e-04-0.2884image
chr9:122816256-122817760:-PCPGGSVA_HALLMARK_TGF_BETA_SIGNALINGEER3.5818e-02-0.1641image
ENSG00000136940.12,PDCLPCPGGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG3.6258e-02-0.1637image
ENSG00000136940.12,PDCLPRADGSVA_HALLMARK_SPERMATOGENESISEAG9.7861e-040.1546image
ENSG00000136940.12,PDCLREADGSVA_HALLMARK_PROTEIN_SECRETIONEAG4.1746e-020.2553image
ENSG00000136940.12,PDCLSARCGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG2.3612e-020.1596image
chr9:122816256-122817760:-SARCGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER2.6051e-020.1570image
ENSG00000136940.12,PDCLSKCMGSVA_HALLMARK_ANDROGEN_RESPONSEEAG6.6587e-040.1908image
chr9:122816256-122817760:-STADGSVA_HALLMARK_APOPTOSISEER1.1380e-090.3345image
ENSG00000136940.12,PDCLSTADGSVA_HALLMARK_APOPTOSISEAG1.1634e-090.3343image
chr9:122816256-122817760:-TGCTGSVA_HALLMARK_PROTEIN_SECRETIONEER1.4852e-020.2506image
ENSG00000136940.12,PDCLTGCTGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.4518e-020.2514image
chr9:122816256-122817760:-THCAGSVA_HALLMARK_HEME_METABOLISMEER1.6946e-060.2327image
ENSG00000136940.12,PDCLTHCAGSVA_HALLMARK_HEME_METABOLISMEAG1.8338e-060.2320image
ENSG00000136940.12,PDCLUCECGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG2.6080e-020.2048image
ENSG00000136940.12,PDCLUCSGSVA_HALLMARK_COAGULATIONEAG3.9499e-02-0.3400image


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7. Enriched editing regions and drugs for PDCL


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000136940.12,PDCLBLCALapatinibEAG3.4910e-02-0.1259image
ENSG00000136940.12,PDCLBRCAABT.263EAG6.0707e-040.1116image
chr9:122816256-122817760:-BRCAABT.263EER6.6521e-040.1108image
ENSG00000136940.12,PDCLCESCAZD7762EAG3.9844e-030.1884image
ENSG00000136940.12,PDCLCHOLDasatinibEAG1.2755e-020.5218image
chr9:122816256-122817760:-COADAZD8055EER3.5103e-020.1555image
ENSG00000136940.12,PDCLCOADAZD8055EAG3.5103e-020.1555image
ENSG00000136940.12,PDCLDLBCBosutinibEAG6.5404e-030.5194image
chr9:122816256-122817760:-ESCAImatinibEER6.5256e-04-0.2675image
ENSG00000136940.12,PDCLESCAImatinibEAG7.9544e-04-0.2634image
ENSG00000136940.12,PDCLGBMBI.D1870EAG2.9982e-060.3732image
chr9:122816256-122817760:-GBMBI.D1870EER2.9982e-060.3732image
chr9:122816256-122817760:-HNSCCI.1040EER4.1958e-04-0.1798image
ENSG00000136940.12,PDCLHNSCCI.1040EAG4.2751e-04-0.1794image
ENSG00000136940.12,PDCLKICHCCT018159EAG6.9234e-030.3509image
ENSG00000136940.12,PDCLKIRCBMS.754807EAG3.9725e-040.1902image
chr9:122816256-122817760:-KIRCBMS.754807EER4.0685e-040.1899image
ENSG00000136940.12,PDCLKIRPGW.441756EAG4.0345e-03-0.2145image
ENSG00000136940.12,PDCLLGGKIN001.135EAG2.8074e-04-0.1660image
chr9:122816256-122817760:-LIHCCHIR.99021EER1.1563e-02-0.2456image
ENSG00000136940.12,PDCLLIHCCHIR.99021EAG1.1529e-02-0.2457image
ENSG00000136940.12,PDCLLUADLenalidomideEAG9.8524e-030.1337image
chr9:122816256-122817760:-LUSCImatinibEER6.3211e-030.1439image
ENSG00000136940.12,PDCLLUSCImatinibEAG6.2779e-030.1440image
ENSG00000136940.12,PDCLMESOCHIR.99021EAG6.2734e-03-0.3641image
ENSG00000136940.12,PDCLOVDMOGEAG1.2709e-02-0.1590image
chr9:122816256-122817760:-OVDMOGEER1.3081e-02-0.1584image
ENSG00000136940.12,PDCLPAADMetforminEAG6.8719e-030.2360image
chr9:122816256-122817760:-PAADMetforminEER6.8719e-030.2360image
chr9:122816256-122817760:-PCPGBleomycinEER4.9819e-030.2183image
ENSG00000136940.12,PDCLPCPGBleomycinEAG5.0889e-030.2178image
ENSG00000136940.12,PDCLPRADBI.D1870EAG4.8618e-030.1322image
ENSG00000136940.12,PDCLSKCMJNJ.26854165EAG3.7069e-03-0.1631image
ENSG00000136940.12,PDCLSTADAZ628EAG1.4401e-04-0.2126image
chr9:122816256-122817760:-STADAZ628EER1.2252e-04-0.2147image
chr9:122816256-122817760:-TGCTBryostatin.1EER1.1399e-020.2600image
ENSG00000136940.12,PDCLTGCTBryostatin.1EAG1.0940e-020.2614image
chr9:122816256-122817760:-THCACytarabineEER3.8497e-060.2248image
ENSG00000136940.12,PDCLTHCACytarabineEAG3.8842e-060.2247image
ENSG00000136940.12,PDCLTHYMElesclomolEAG8.2598e-030.2881image
ENSG00000136940.12,PDCLUCECCyclopamineEAG1.2347e-02-0.2297image
ENSG00000136940.12,PDCLUCSBMS.536924EAG1.3006e-030.5088image
ENSG00000136940.12,PDCLUVMMetforminEAG9.6445e-05-0.6797image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType